Regulating hearing aid compatibility of cell phones: results from a national survey.

Authors: Jones ML, Morris JT, Mueller JL, Lippincott B, Sweatman WM Abstract Accessibility of telecommunication technologies by people who are deaf or hard of hearing has been a critical issue since the invention of the telephone. As both telephone and hearing-aid technologies have evolved, finding compatible solutions has been an ongoing challenge. This paper uses the findings of a longitudinal study to examine the impact of Federal hearing-aid compatibility (HAC) regulations in resolving this problem. The study ran concurrently with the phase-in of Federal Communications Commission regulations requiring that mobile handset manufacturers and wireless service providers make available minimum numbers of cell phones with shielding to reduce electromagnetic interference when cell phon...

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Regulating hearing aid compatibility of cell phones: results from a national survey.

Authors: Jones ML, Morris JT, Mueller JL, Lippincott B, Sweatman WM Abstract Accessibility of telecommunication technologies by people who are deaf or hard of hearing has been a critical issue since the invention of the telephone. As both telephone and hearing-aid technologies have evolved, finding compatible solutions has been an ongoing challenge. This paper uses the findings of a longitudinal study to examine the impact of Federal hearing-aid compatibility (HAC) regulations in resolving this problem. The study ran concurrently with the phase-in of Federal Communications Commission regulations requiring that mobile handset manufacturers and wireless service providers make available minimum numbers of cell phones with shielding to reduce electromagnetic interference when cell phon...

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Long-term quality of life outcomes of maxillomandibular advancement osteotomy in patients with obstructive sleep apnoea syndrome

This study was performed to evaluate the long-term impact of maxillomandibular advancement (MMA) surgery on the apnoea –hypopnoea index (AHI) and quality of life (QoL) in patients with obstructive sleep apnoea syndrome (OSAS). The medical files of 12 OSAS patients who underwent MMA by one surgeon between 1995 and 1999 were reviewed retrospectively. Patients received a clinical assessment, polysomnography, and QoL questionnaires as part of routine care preoperatively (n=12), within 2 years postoperative (n=12), and again in 2016 (n=9). (Source: International Journal of Oral and Maxillofacial Surgery)

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Long-term quality of life outcomes of maxillomandibular advancement osteotomy in patients with obstructive sleep apnoea syndrome

This study was performed to evaluate the long-term impact of maxillomandibular advancement (MMA) surgery on the apnoea –hypopnoea index (AHI) and quality of life (QoL) in patients with obstructive sleep apnoea syndrome (OSAS). The medical files of 12 OSAS patients who underwent MMA by one surgeon between 1995 and 1999 were reviewed retrospectively. Patients received a clinical assessment, polysomnography, and QoL questionnaires as part of routine care preoperatively (n=12), within 2 years postoperative (n=12), and again in 2016 (n=9). (Source: International Journal of Oral and Maxillofacial Surgery)

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DG HEALTH ALLERGY RELIEF (Diphenhydramine Hydrochloride) Capsule [Dolgencorp, LLC]

Updated Date: Oct 18, 2018 EST (Source: DailyMed Drug Label Updates)

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Feel Good Foods Inc Issues Allergy Alert on Undeclared Egg Product In “ Vegetable Fried Rice ”

Feel Good Foods Inc. of Brooklyn, NY is recalling six lots of " Vegetable Fried Rice " frozen meals, UPC 00899039002129 because they may contain undeclared egg. People who have allergies to egg run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Safety)

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Apollo Food International Inc Issues Allergy Alert on Undeclared Eggs In “ Mini Roll ”

Apollo Food International Inc. of Long Island City, NY, is recalling its 2.469 ounce packages of " Mini Roll " food treats because they may contain undeclared eggs. Consumers who are allergic to eggs may run the risk of serious or life-threatening allergic reactions if they consume this product. (Source: FDA Food Safety)

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DG HEALTH ALLERGY RELIEF (Diphenhydramine Hydrochloride) Capsule [Dolgencorp, LLC]

Updated Date: Oct 18, 2018 EST (Source: DailyMed Drug Label Updates)

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Feel Good Foods Inc Issues Allergy Alert on Undeclared Egg Product In “ Vegetable Fried Rice ”

Feel Good Foods Inc. of Brooklyn, NY is recalling six lots of " Vegetable Fried Rice " frozen meals, UPC 00899039002129 because they may contain undeclared egg. People who have allergies to egg run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Safety)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OAOwoX

Apollo Food International Inc Issues Allergy Alert on Undeclared Eggs In “ Mini Roll ”

Apollo Food International Inc. of Long Island City, NY, is recalling its 2.469 ounce packages of " Mini Roll " food treats because they may contain undeclared eggs. Consumers who are allergic to eggs may run the risk of serious or life-threatening allergic reactions if they consume this product. (Source: FDA Food Safety)

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Prospective Multicenter Study of Changes in MTT after Aneurysmal SAH and Relationship to Delayed Cerebral Ischemia in Patients with Good- and Poor-Grade Admission Status [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Patients with aneurysmal SAH and good clinical status at admission are considered at a lower risk for delayed cerebral ischemia. Prolonged MTT may be associated with an increased risk. It is unclear whether this is dependent on clinical status. Our purpose was to determine whether increased MTT within 3 days of aneurysmal SAH compared with baseline is associated with a higher risk of delayed cerebral ischemia in patients with good (World Federation of Neurosurgical Societies I–III) versus poor (World Federation of Neurosurgical Societies IV–V) admission status.

MATERIALS AND METHODS:

This prolonged MTT was a multicenter, prospective cohort investigation of 87 patients with aneurysmal SAH. MTT was measured at admission before aneurysm treatment (MTT1) and following repair (MTT2) within 3 days of admission; MTT_diff was calculated as the difference between MTT2 and MTT1. Changes in MTT across time were assessed with repeated measures analyses. Risk of delayed cerebral ischemia or death was determined with multivariate logistic regression analysis.

RESULTS:

In patients with a good grade (n = 49), MTT was prolonged in patients who developed delayed cerebral ischemia, with MTT_diff significantly greater (0.82 ± 1.5) compared with those who did not develop delayed cerebral ischemia (–0.14 ± 0.98) (P = .03). Prolonged MTT was associated with a significantly higher risk of delayed cerebral ischemia or death (OR = 3.1; 95% CI, 1.3–7.4; P = .014) on multivariate analysis. In patients with poor grades (n = 38), MTT_diff was not greater in patients who developed delayed cerebral ischemia; MTT1 was significantly prolonged compared with patients with a good grade.

CONCLUSIONS:

Patients in good clinical condition following aneurysmal SAH but with increasing MTT in the first few days after aneurysmal SAH are at high risk of delayed cerebral ischemia and warrant close clinical monitoring.

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Outcomes of Stent Retriever versus Aspiration-First Thrombectomy in Ischemic Stroke: A Systematic Review and Meta-Analysis [INTERVENTIONAL]

BACKGROUND:

There is ongoing debate regarding the optimal first-line thrombectomy technique for large-vessel occlusion.

PURPOSE:

We performed a systematic review and meta-analysis of comparative studies on stent retriever–first and aspiration-first thrombectomy.

DATA SOURCES:

We searched Ovid MEDLINE, PubMed, and EMBASE from 2009 to February 2018.

STUDY SELECTION:

Two reviewers independently selected the studies. The primary end point was successful reperfusion (TICI 2b/3).

DATA ANALYSIS:

Random-effects meta-analysis was used for analysis.

DATA SYNTHESIS:

Eighteen studies including 2893 patients were included. There was no significant difference in the rate of final successful reperfusion (83.9% versus 83.3%; OR = 0.87; 95% CI, 0.62%–1.27%) or good functional outcome (mRS 0–2) at 90 days (OR = 1.07; 95% CI, 0.80–1.44) between the stent-retriever thrombectomy and aspiration groups. The stent-retriever thrombectomy–first group achieved a statistically significant higher TICI 2b/3 rate after the first-line device than the aspiration-first group (74.9% versus 66.4%; OR = 1.53; 95% CI, 1.14%–2.05%) and resulted in lower use of a rescue device (19.9% versus 32.5%; OR = 0.36; 95% CI, 0.14%–0.90%). The aspiration-first approach resulted in a statistically shorter groin-to-reperfusion time (weighted mean difference, 7.15 minutes; 95% CI, 1.63–12.67 minutes). There was no difference in the number of passes, symptomatic intracerebral hemorrhage, vessel dissection or perforation, and mortality between groups.

LIMITATIONS:

Most of the included studies were nonrandomized. There was significant heterogeneity in some of the outcome variables.

CONCLUSIONS:

Stent-retriever thrombectomy–first and aspiration-first thrombectomy were associated with comparable final reperfusion rates and functional outcome. Stent-retriever thrombectomy was superior in achieving reperfusion as a stand-alone first-line technique, with lower use of rescue devices but a longer groin-to-reperfusion time.

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Aberrant Structural Brain Connectivity in Adolescents with Attentional Problems Who Were Born Prematurely [PEDIATRICS]

BACKGROUND AND PURPOSE:

Differences in structural brain connectivity that underlie inattention have been previously investigated in adolescents with attention deficit/hyperactivity disorder, but not in the context of premature birth, which is often associated with attentional problems. The purpose of this study was to identify the neural correlates of attentional problems in adolescents born prematurely and determine neonatal predictors of those neural correlates and attention problems.

MATERIALS AND METHODS:

The study included 24 adolescents (12.5 ± 1.8 years of age; 12 girls, 12 boys) who were born prematurely and underwent MR imaging of the brain and cognitive assessment, both shortly after birth and as adolescents. Structural connectivity was assessed at adolescence using diffusion tensor imaging and tractography.

RESULTS:

Of the 24 subjects, 12 had attention deficits. A set of axonal pathways connecting the frontal, parietal, temporal, and occipital lobes had significantly lower fractional anisotropy in subjects with attentional problems. The temporoparietal connection between the left precuneus and left middle temporal gyrus was the most significantly underconnected interlobar axonal pathway. Low birth weight and ventriculomegaly, but not white matter injury or intraventricular hemorrhage on neonatal MR imaging, predicted temporoparietal hypoconnectivity in adolescence. However, neither birth weight nor other neonatal characteristics were associated with attention deficits directly.

CONCLUSIONS:

We identified an aberrant structural brain connectivity pattern, involving temporoparietal hypoconnectivity, in prematurely born adolescents with attentional problems. We also identified birth weight as a potential neonatal predictor of the temporoparietal hypoconnectivity. These findings add to our understanding of the neural basis and etiology of inattention in adolescents after premature birth.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ExORUA

Systematic Assessment of Multispectral Voxel-Based Morphometry in Previously MRI-Negative Focal Epilepsy [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Voxel-based morphometry is widely used for detecting gray matter abnormalities in epilepsy. However, its performance with changing parameters, smoothing and statistical threshold, is debatable. More important, the potential yield of combining multiple MR imaging contrasts (multispectral voxel-based morphometry) is still unclear. Our aim was to objectify smoothing and statistical cutoffs and systematically compare the performance of multispectral voxel-based morphometry with existing T1 voxel-based morphometry in patients with focal epilepsy and previously negative MRI.

MATERIALS AND METHODS:

3D T1-, T2-, and T2-weighted FLAIR scans were acquired for 62 healthy volunteers and 13 patients with MR imaging negative for focal epilepsy on a Magnetom Skyra 3T scanner with an isotropic resolution of 0.9 mm³. We systematically optimized the main voxel-based morphometry parameters, smoothing level and statistical cutoff, with T1 voxel-based morphometry as a reference. As a next step, the performance of multispectral voxel-based morphometry models, T1+T2, T1+FLAIR, and T1+T2+FLAIR, was compared with that of T1 voxel-based morphometry using gray matter concentration and gray matter volume analysis.

RESULTS:

We found the best performance of T1 at 12 mm and a T-threshold (statistical cutoff) of 3.7 for gray matter concentration analysis. When we incorporated these parameters, after expert visual interpretation of concordant and discordant findings, we identified T1+FLAIR as the best model with a concordant rate of 46.2% and a concordant rate/discordant rate of 1.20 compared with T1 with 30.8% and 0.67, respectively. Visual interpretation of voxel-based morphometry findings decreased concordant rates from 38.5%–46.2% to 15.4%–46.2% and discordant rates from 53.8%–84.6% to 30.8%–46.2% and increased specificity across models from 33.9%–40.3% to 46.8%–54.8%.

CONCLUSIONS:

Multispectral voxel-based morphometry, especially T1+FLAIR, can yield superior results over single-channel T1 in focal epilepsy patients with a negative conventional MR imaging.

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The Central Vein: FLAIR Signal Abnormalities Associated with Developmental Venous Anomalies in Patients with Multiple Sclerosis [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Demyelination is a recently recognized cause of FLAIR hyperintensities associated with developmental venous anomalies. Our purpose was to quantify the prevalence of white matter signal abnormalities associated with developmental venous anomalies in patients with multiple sclerosis compared with controls.

MATERIALS AND METHODS:

A retrospective, blinded, multireader study compared the prevalence of FLAIR hyperintense signal abnormalities adjacent to developmental venous anomalies in patients with MS compared with controls (patients with developmental venous anomalies without MS). Study findings were positive if a central vein was demonstrated using FLAIR and contrast-enhanced fat-saturated T1 sequences. Imaging parameters also included developmental venous anomaly location, developmental venous anomaly drainage, white matter lesion size, and depth of white matter lesions. Clinical parameters included age, sex, and the presence of confounding variables (hypertension, diabetes, migraines, and/or vasculopathy).

RESULTS:

FLAIR signal abnormality was present around 47.3% (35/74) of developmental venous anomalies in patients with MS, and 13.5% (10/74) of developmental venous anomalies in the control group (P < .001). The multivariate logistic regression model controlling for covariates (including migraines, hypertension, diabetes mellitus, vasculopathy, age, sex, and drainage direction of developmental venous anomalies) showed that the odds of FLAIR hyperintensity around developmental venous anomalies was 6.7-fold higher in patients with MS (relative risk MS = 6.68; 95% CI, 2.79–15.97; P < .001).

CONCLUSIONS:

The association of developmental venous anomalies and FLAIR hyperintensities was more common in patients with MS, which suggests that the underlying demyelinating pathologic process of MS may be the cause of this propensity in patients with MS. Impaired venous drainage in the territory of developmental venous anomalies may predispose to development of these lesions, and an associated central vein is helpful in understanding an atypical location of MS plaques.

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MR Imaging in Meniere Disease: Is the Contact between the Vestibular Endolymphatic Space and the Oval Window a Reliable Biomarker? [HEAD & NECK]

BACKGROUND AND PURPOSE:

No reliable MR imaging marker for the diagnosis of Menière disease has been reported. Our aim was to investigate whether the obliteration of the inferior portion of the vestibule and the contact with the stapes footplate by the vestibular endolymphatic space are reliable MR imaging markers in the diagnosis of Menière disease.

MATERIALS AND METHODS:

We retrospectively enrolled 49 patients, 24 affected by unilateral sudden hearing loss and 25 affected by definite Menière disease, who had undergone a 4-hour delayed 3D-FLAIR sequence. Two readers analyzed the MR images investigating whether the vestibular endolymphatic space bulged in the third inferior portion of the vestibule contacting the stapes footplate. This sign was defined as the vestibular endolymphatic space contacting the oval window.

RESULTS:

We analyzed 98 ears: 27 affected by Menière disease, 24 affected by sudden sensorineural hearing loss, and 47 that were healthy. The vestibular endolymphatic space contacting the oval window showed an almost perfect interobserver agreement (Cohen = 0.87; 95% CI, 0.69–1). The vestibular endolymphatic space contacting oval window showed the following: sensitivity = 81%, specificity = 96%, positive predictive value = 88%, and negative predictive value = 93% in differentiating Menière disease ears from other ears. The vestibular endolymphatic space contacting the oval window showed the following: sensitivity = 81%, specificity = 96%, positive predictive value = 96%, negative predictive value = 82% in differentiating Menière disease ears from sudden sensorineural hearing loss ears.

CONCLUSIONS:

The vestibular endolymphatic space contacting the oval window has high specificity and positive predictive value in differentiating Menière disease ears from other ears, thus resulting in a valid tool for ruling in Menière disease in patients with mimicking symptoms.

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Outcomes of Stent Retriever versus Aspiration-First Thrombectomy in Ischemic Stroke: A Systematic Review and Meta-Analysis [INTERVENTIONAL]

BACKGROUND:

There is ongoing debate regarding the optimal first-line thrombectomy technique for large-vessel occlusion.

PURPOSE:

We performed a systematic review and meta-analysis of comparative studies on stent retriever–first and aspiration-first thrombectomy.

DATA SOURCES:

We searched Ovid MEDLINE, PubMed, and EMBASE from 2009 to February 2018.

STUDY SELECTION:

Two reviewers independently selected the studies. The primary end point was successful reperfusion (TICI 2b/3).

DATA ANALYSIS:

Random-effects meta-analysis was used for analysis.

DATA SYNTHESIS:

Eighteen studies including 2893 patients were included. There was no significant difference in the rate of final successful reperfusion (83.9% versus 83.3%; OR = 0.87; 95% CI, 0.62%–1.27%) or good functional outcome (mRS 0–2) at 90 days (OR = 1.07; 95% CI, 0.80–1.44) between the stent-retriever thrombectomy and aspiration groups. The stent-retriever thrombectomy–first group achieved a statistically significant higher TICI 2b/3 rate after the first-line device than the aspiration-first group (74.9% versus 66.4%; OR = 1.53; 95% CI, 1.14%–2.05%) and resulted in lower use of a rescue device (19.9% versus 32.5%; OR = 0.36; 95% CI, 0.14%–0.90%). The aspiration-first approach resulted in a statistically shorter groin-to-reperfusion time (weighted mean difference, 7.15 minutes; 95% CI, 1.63–12.67 minutes). There was no difference in the number of passes, symptomatic intracerebral hemorrhage, vessel dissection or perforation, and mortality between groups.

LIMITATIONS:

Most of the included studies were nonrandomized. There was significant heterogeneity in some of the outcome variables.

CONCLUSIONS:

Stent-retriever thrombectomy–first and aspiration-first thrombectomy were associated with comparable final reperfusion rates and functional outcome. Stent-retriever thrombectomy was superior in achieving reperfusion as a stand-alone first-line technique, with lower use of rescue devices but a longer groin-to-reperfusion time.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2S043ww

Spinal Epidural Arteriovenous Fistula with Perimedullary Venous Reflux: Clinical and Neuroradiologic Features of an Underestimated Vascular Disorder [SPINE]

BACKGROUND AND PURPOSE:

The purpose of this study was to discuss the clinical and radiologic characteristics of spinal epidural arteriovenous fistulas (SEAVF) and demonstrate their specific angiomorphology in a single-center series.

MATERIALS AND METHODS:

Thirteen consecutive patients were diagnosed with SEAVF at RWTH Aachen University Hospital between 2006 and 2018 and were included in this study. All patients had MR imaging and DSA before treatment; 10 of these 13 patients received contrast-enhanced MRA (CE-MRA).

RESULTS:

The mean patient age was 72 ± 8 years. Paraparesis was present in 12 (92%) patients. Sphincter dysfunction and sensory symptoms were observed in 7 (54%) and 6 (46%) patients, respectively. The mean duration of symptoms was 6 ± 8 months. Congestive myelopathy on MR imaging was present in all patients. Prominent arterialized perimedullary veins were demonstrated in only 3 cases. CE-MRA revealed arterialized perimedullary veins and an arterialized epidural pouch in 9/10 (90%) patients, mostly located ventrolaterally. DSA demonstrated a multisegmental extension of the arterialized ventrolateral epidural pouch in 6 (46%) cases. An intradural radicular drainage vein was localized distant from the original fistula point in 3 (23%) patients.

CONCLUSIONS:

Congestive myelopathy with an acute/subacute clinical course was the dominant finding in spinal epidural arteriovenous fistulas. CE-MRA is a powerful diagnostic tool for identifying arterialized perimedullary veins as well as an arterialized epidural pouch. While arterialized perimedullary veins frequently present with only mild enlargement and elongation in spinal epidural arteriovenous fistulas, the arterialized epidural pouch is frequently located ventrolaterally and may extend over several vertebral levels. DSA remains the criterion standard to precisely visualize a spinal epidural arteriovenous fistula and its intradural radicular drainage vein, which may be located distant from the fistulous point.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2S042IY

Aberrant Structural Brain Connectivity in Adolescents with Attentional Problems Who Were Born Prematurely [PEDIATRICS]

BACKGROUND AND PURPOSE:

Differences in structural brain connectivity that underlie inattention have been previously investigated in adolescents with attention deficit/hyperactivity disorder, but not in the context of premature birth, which is often associated with attentional problems. The purpose of this study was to identify the neural correlates of attentional problems in adolescents born prematurely and determine neonatal predictors of those neural correlates and attention problems.

MATERIALS AND METHODS:

The study included 24 adolescents (12.5 ± 1.8 years of age; 12 girls, 12 boys) who were born prematurely and underwent MR imaging of the brain and cognitive assessment, both shortly after birth and as adolescents. Structural connectivity was assessed at adolescence using diffusion tensor imaging and tractography.

RESULTS:

Of the 24 subjects, 12 had attention deficits. A set of axonal pathways connecting the frontal, parietal, temporal, and occipital lobes had significantly lower fractional anisotropy in subjects with attentional problems. The temporoparietal connection between the left precuneus and left middle temporal gyrus was the most significantly underconnected interlobar axonal pathway. Low birth weight and ventriculomegaly, but not white matter injury or intraventricular hemorrhage on neonatal MR imaging, predicted temporoparietal hypoconnectivity in adolescence. However, neither birth weight nor other neonatal characteristics were associated with attention deficits directly.

CONCLUSIONS:

We identified an aberrant structural brain connectivity pattern, involving temporoparietal hypoconnectivity, in prematurely born adolescents with attentional problems. We also identified birth weight as a potential neonatal predictor of the temporoparietal hypoconnectivity. These findings add to our understanding of the neural basis and etiology of inattention in adolescents after premature birth.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ExORUA

Systematic Assessment of Multispectral Voxel-Based Morphometry in Previously MRI-Negative Focal Epilepsy [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Voxel-based morphometry is widely used for detecting gray matter abnormalities in epilepsy. However, its performance with changing parameters, smoothing and statistical threshold, is debatable. More important, the potential yield of combining multiple MR imaging contrasts (multispectral voxel-based morphometry) is still unclear. Our aim was to objectify smoothing and statistical cutoffs and systematically compare the performance of multispectral voxel-based morphometry with existing T1 voxel-based morphometry in patients with focal epilepsy and previously negative MRI.

MATERIALS AND METHODS:

3D T1-, T2-, and T2-weighted FLAIR scans were acquired for 62 healthy volunteers and 13 patients with MR imaging negative for focal epilepsy on a Magnetom Skyra 3T scanner with an isotropic resolution of 0.9 mm³. We systematically optimized the main voxel-based morphometry parameters, smoothing level and statistical cutoff, with T1 voxel-based morphometry as a reference. As a next step, the performance of multispectral voxel-based morphometry models, T1+T2, T1+FLAIR, and T1+T2+FLAIR, was compared with that of T1 voxel-based morphometry using gray matter concentration and gray matter volume analysis.

RESULTS:

We found the best performance of T1 at 12 mm and a T-threshold (statistical cutoff) of 3.7 for gray matter concentration analysis. When we incorporated these parameters, after expert visual interpretation of concordant and discordant findings, we identified T1+FLAIR as the best model with a concordant rate of 46.2% and a concordant rate/discordant rate of 1.20 compared with T1 with 30.8% and 0.67, respectively. Visual interpretation of voxel-based morphometry findings decreased concordant rates from 38.5%–46.2% to 15.4%–46.2% and discordant rates from 53.8%–84.6% to 30.8%–46.2% and increased specificity across models from 33.9%–40.3% to 46.8%–54.8%.

CONCLUSIONS:

Multispectral voxel-based morphometry, especially T1+FLAIR, can yield superior results over single-channel T1 in focal epilepsy patients with a negative conventional MR imaging.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RY7rrD

MR Imaging in Meniere Disease: Is the Contact between the Vestibular Endolymphatic Space and the Oval Window a Reliable Biomarker? [HEAD & NECK]

BACKGROUND AND PURPOSE:

No reliable MR imaging marker for the diagnosis of Menière disease has been reported. Our aim was to investigate whether the obliteration of the inferior portion of the vestibule and the contact with the stapes footplate by the vestibular endolymphatic space are reliable MR imaging markers in the diagnosis of Menière disease.

MATERIALS AND METHODS:

We retrospectively enrolled 49 patients, 24 affected by unilateral sudden hearing loss and 25 affected by definite Menière disease, who had undergone a 4-hour delayed 3D-FLAIR sequence. Two readers analyzed the MR images investigating whether the vestibular endolymphatic space bulged in the third inferior portion of the vestibule contacting the stapes footplate. This sign was defined as the vestibular endolymphatic space contacting the oval window.

RESULTS:

We analyzed 98 ears: 27 affected by Menière disease, 24 affected by sudden sensorineural hearing loss, and 47 that were healthy. The vestibular endolymphatic space contacting the oval window showed an almost perfect interobserver agreement (Cohen = 0.87; 95% CI, 0.69–1). The vestibular endolymphatic space contacting oval window showed the following: sensitivity = 81%, specificity = 96%, positive predictive value = 88%, and negative predictive value = 93% in differentiating Menière disease ears from other ears. The vestibular endolymphatic space contacting the oval window showed the following: sensitivity = 81%, specificity = 96%, positive predictive value = 96%, negative predictive value = 82% in differentiating Menière disease ears from sudden sensorineural hearing loss ears.

CONCLUSIONS:

The vestibular endolymphatic space contacting the oval window has high specificity and positive predictive value in differentiating Menière disease ears from other ears, thus resulting in a valid tool for ruling in Menière disease in patients with mimicking symptoms.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EumOFC

Spinal Epidural Arteriovenous Fistula with Perimedullary Venous Reflux: Clinical and Neuroradiologic Features of an Underestimated Vascular Disorder [SPINE]

BACKGROUND AND PURPOSE:

The purpose of this study was to discuss the clinical and radiologic characteristics of spinal epidural arteriovenous fistulas (SEAVF) and demonstrate their specific angiomorphology in a single-center series.

MATERIALS AND METHODS:

Thirteen consecutive patients were diagnosed with SEAVF at RWTH Aachen University Hospital between 2006 and 2018 and were included in this study. All patients had MR imaging and DSA before treatment; 10 of these 13 patients received contrast-enhanced MRA (CE-MRA).

RESULTS:

The mean patient age was 72 ± 8 years. Paraparesis was present in 12 (92%) patients. Sphincter dysfunction and sensory symptoms were observed in 7 (54%) and 6 (46%) patients, respectively. The mean duration of symptoms was 6 ± 8 months. Congestive myelopathy on MR imaging was present in all patients. Prominent arterialized perimedullary veins were demonstrated in only 3 cases. CE-MRA revealed arterialized perimedullary veins and an arterialized epidural pouch in 9/10 (90%) patients, mostly located ventrolaterally. DSA demonstrated a multisegmental extension of the arterialized ventrolateral epidural pouch in 6 (46%) cases. An intradural radicular drainage vein was localized distant from the original fistula point in 3 (23%) patients.

CONCLUSIONS:

Congestive myelopathy with an acute/subacute clinical course was the dominant finding in spinal epidural arteriovenous fistulas. CE-MRA is a powerful diagnostic tool for identifying arterialized perimedullary veins as well as an arterialized epidural pouch. While arterialized perimedullary veins frequently present with only mild enlargement and elongation in spinal epidural arteriovenous fistulas, the arterialized epidural pouch is frequently located ventrolaterally and may extend over several vertebral levels. DSA remains the criterion standard to precisely visualize a spinal epidural arteriovenous fistula and its intradural radicular drainage vein, which may be located distant from the fistulous point.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2S042IY

Validation of the maximum symptom day among children with asthma

The maximum symptom day, a primary outcome of inner-city asthma research for almost two decades, is a valid measure that consistently relates to asthma control and is predictive of clinically relevant asthma endpoints. (Source: Journal of Allergy and Clinical Immunology)

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Genetic Diversity Between Mouse Strains Allows Identification of CC027/GeniUnc as an Orally Reactive Model of Peanut Allergy

This study demonstrates the use of the genetically diverse Collaborative Cross which identified an improved, orally reactive mouse model of peanut allergy, to study the etiology of food allergy and the development of new therapies. (Source: Journal of Allergy and Clinical Immunology)

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Cytomegalovirus infection incidence and risk factors across diverse hematopoietic cell transplantation platforms using a standardized monitoring and treatment approach: a comprehensive evaluation from a single institution

Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for a variety of benign and malignant hematologic and immunologic conditions. Despite diagnostic and therapeutic advances in the management of post-HCT opportunistic infections, human cytomegalovirus (CMV) remains associated with significant morbidity, organ toxicity, and transplant-related mortality.1-3 Uncontrolled CMV infection can lead to pneumonitis or enterocolitis, and more rarely hepatitis, retinitis, and encephalitis. (Source: Biology of Blood and Marrow Transplantation)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NNiDnJ

Validation of the maximum symptom day among children with asthma

The maximum symptom day, a primary outcome of inner-city asthma research for almost two decades, is a valid measure that consistently relates to asthma control and is predictive of clinically relevant asthma endpoints. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PIzYAa

Genetic Diversity Between Mouse Strains Allows Identification of CC027/GeniUnc as an Orally Reactive Model of Peanut Allergy

This study demonstrates the use of the genetically diverse Collaborative Cross which identified an improved, orally reactive mouse model of peanut allergy, to study the etiology of food allergy and the development of new therapies. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PfwFDD

Cytomegalovirus infection incidence and risk factors across diverse hematopoietic cell transplantation platforms using a standardized monitoring and treatment approach: a comprehensive evaluation from a single institution

Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for a variety of benign and malignant hematologic and immunologic conditions. Despite diagnostic and therapeutic advances in the management of post-HCT opportunistic infections, human cytomegalovirus (CMV) remains associated with significant morbidity, organ toxicity, and transplant-related mortality.1-3 Uncontrolled CMV infection can lead to pneumonitis or enterocolitis, and more rarely hepatitis, retinitis, and encephalitis. (Source: Biology of Blood and Marrow Transplantation)

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Cochlear implantation in children with auditory neuropathy: Lessons from Brown –Vialetto–Van Laere syndrome

. (Source: Cochlear Implants International)

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Cochlear implantation in children with auditory neuropathy: Lessons from Brown –Vialetto–Van Laere syndrome

. (Source: Cochlear Implants International)

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Clinical Thyroidology®High-Impact Articles

FREE ACCESS through November 1, 2018.
Read Now:

Paul Walfish—In Memoriam
Anthony Hollenberg, Jerome M. Hershman 

Radioactive Iodine Therapy Is Associated with Clonal Hematopoiesis, a Precursor for Hematologic Malignancies
Brian W. Kim  

Persistent Disease is 3.5-Fold More Common Than Recurrent Disease After Initial Therapy for Differentiated Thyroid Cancer
Jerome M Hershman  

Male Sex Is Associated with Increased Mortality from Papillary Thyroid Cancers with BRAF V600E Mutation
Lauren E. Orr, Michael W. Yeh, Masha J. Livhits  

Varying Levothyroxine Doses Within or Near the Reference Range Does Not Affect Energy Expenditure or Body Composition
Elizabeth N. Pearce  

Levothyroxine Replacement for Primary Hypothyroidism Can Be Given Between Meals with Similar Effectiveness at Various Times of the Day
Charles H. Emerson

The post Clinical Thyroidology^®High-Impact Articles appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHRpAT

Clinical Thyroidology®High-Impact Articles

FREE ACCESS through November 1, 2018.
Read Now:

Paul Walfish—In Memoriam
Anthony Hollenberg, Jerome M. Hershman 

Radioactive Iodine Therapy Is Associated with Clonal Hematopoiesis, a Precursor for Hematologic Malignancies
Brian W. Kim  

Persistent Disease is 3.5-Fold More Common Than Recurrent Disease After Initial Therapy for Differentiated Thyroid Cancer
Jerome M Hershman  

Male Sex Is Associated with Increased Mortality from Papillary Thyroid Cancers with BRAF V600E Mutation
Lauren E. Orr, Michael W. Yeh, Masha J. Livhits  

Varying Levothyroxine Doses Within or Near the Reference Range Does Not Affect Energy Expenditure or Body Composition
Elizabeth N. Pearce  

Levothyroxine Replacement for Primary Hypothyroidism Can Be Given Between Meals with Similar Effectiveness at Various Times of the Day
Charles H. Emerson

The post Clinical Thyroidology^®High-Impact Articles appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHRpAT

Clinical Thyroidology®High-Impact Articles

FREE ACCESS through November 1, 2018.
Read Now:

Paul Walfish—In Memoriam
Anthony Hollenberg, Jerome M. Hershman 

Radioactive Iodine Therapy Is Associated with Clonal Hematopoiesis, a Precursor for Hematologic Malignancies
Brian W. Kim  

Persistent Disease is 3.5-Fold More Common Than Recurrent Disease After Initial Therapy for Differentiated Thyroid Cancer
Jerome M Hershman  

Male Sex Is Associated with Increased Mortality from Papillary Thyroid Cancers with BRAF V600E Mutation
Lauren E. Orr, Michael W. Yeh, Masha J. Livhits  

Varying Levothyroxine Doses Within or Near the Reference Range Does Not Affect Energy Expenditure or Body Composition
Elizabeth N. Pearce  

Levothyroxine Replacement for Primary Hypothyroidism Can Be Given Between Meals with Similar Effectiveness at Various Times of the Day
Charles H. Emerson

The post Clinical Thyroidology^®High-Impact Articles appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHRpAT

Human Microglial Cells Undergo Proapoptotic Induction and Inflammatory Activation upon in vitro Exposure to a Naturally Occurring Level of Aflatoxin B < sub > 1 < /sub >

Conclusion: Our work confirmed that the environmentally relevant level of AFB1 could cause an inflammatory reaction in human microglial cells that is potentially harmful or toxic to the homeostasis of the human central nervous system and might increase susceptibility to neurodegenerative diseases.Neuroimmunomodulation (Source: Neuroimmunomodulation)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHhIXM

Can we treat systemic lupus erythematosus and other autoimmune diseases without oral steroids?

Authors: Enriquez Merayo E, Sciascia S, Roccatello D, Cuadrado MJ PMID: 30328733 [PubMed - as supplied by publisher] (Source: Expert Review of Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P5psWw

Demographic and Clinical Features of Pediatric Uveitis in Israel.

CONCLUSION: The pattern of pediatric uveitis in Israel is similar to that in the western world. Visual outcome was good in most eyes. PMID: 30332547 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PdpnQM

Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto's Thyroiditis: A Cross-Sectional Study.

CONCLUSIONS: Elevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT. Based on these results, we recommend screening for TgAb antibodies in HT patients with symptom burden. We also suggest that further work on understandings of symptoms appearance due to their autoimmune or hypothyroid causation is needed. PMID: 30332318 [PubMed - as supplied by publisher] (Source: Immunological Investigations)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHSUyK

The coexistence of pemphigus and psoriasis: a systematic review and meta-analysis

In conclusion, a significant association was found between pemphigus and psoriasis. Physicians managing patients with pemphigus may be aware of this comorbidity. Further studies are warranted to establish the precise mechanisms underlying this relationship. (Source: Immunologic Research)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P2Iqgz

Validation of the maximum symptom day among children with asthma

The maximum symptom day, a primary outcome of inner-city asthma research for almost two decades, is a valid measure that consistently relates to asthma control and is predictive of clinically relevant asthma endpoints. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PIzYAa

Human Microglial Cells Undergo Proapoptotic Induction and Inflammatory Activation upon in vitro Exposure to a Naturally Occurring Level of Aflatoxin B < sub > 1 < /sub >

Conclusion: Our work confirmed that the environmentally relevant level of AFB1 could cause an inflammatory reaction in human microglial cells that is potentially harmful or toxic to the homeostasis of the human central nervous system and might increase susceptibility to neurodegenerative diseases.Neuroimmunomodulation (Source: Neuroimmunomodulation)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHhIXM

Genetic Diversity Between Mouse Strains Allows Identification of CC027/GeniUnc as an Orally Reactive Model of Peanut Allergy

This study demonstrates the use of the genetically diverse Collaborative Cross which identified an improved, orally reactive mouse model of peanut allergy, to study the etiology of food allergy and the development of new therapies. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PfwFDD

Can we treat systemic lupus erythematosus and other autoimmune diseases without oral steroids?

Authors: Enriquez Merayo E, Sciascia S, Roccatello D, Cuadrado MJ PMID: 30328733 [PubMed - as supplied by publisher] (Source: Expert Review of Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P5psWw

Antinuclear antibodies in Frontotemporal Dementia: the tip's of autoimmunity iceberg?

We reported a significant increase of antinuclear autoantibodies (ANA) positivity in 100 FTD patients as compared to 100 healthy controls (HC) (60% vs. 13%, p   (Source: Journal of Neuroimmunology)

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Correction.

Authors: PMID: 30332544 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHvhGu

Infection burden and immunological responses are equivalent for polymeric and metallic implant materials in vitro and in a murine model of fracture ‐related infection

Journal of Biomedical Materials Research Part B: Applied Biomaterials, EarlyView. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PdoMyw

Demographic and Clinical Features of Pediatric Uveitis in Israel.

CONCLUSION: The pattern of pediatric uveitis in Israel is similar to that in the western world. Visual outcome was good in most eyes. PMID: 30332547 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PdpnQM

Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto's Thyroiditis: A Cross-Sectional Study.

CONCLUSIONS: Elevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT. Based on these results, we recommend screening for TgAb antibodies in HT patients with symptom burden. We also suggest that further work on understandings of symptoms appearance due to their autoimmune or hypothyroid causation is needed. PMID: 30332318 [PubMed - as supplied by publisher] (Source: Immunological Investigations)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHSUyK

The coexistence of pemphigus and psoriasis: a systematic review and meta-analysis

In conclusion, a significant association was found between pemphigus and psoriasis. Physicians managing patients with pemphigus may be aware of this comorbidity. Further studies are warranted to establish the precise mechanisms underlying this relationship. (Source: Immunologic Research)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P2Iqgz

Validation of the maximum symptom day among children with asthma

The maximum symptom day, a primary outcome of inner-city asthma research for almost two decades, is a valid measure that consistently relates to asthma control and is predictive of clinically relevant asthma endpoints. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PIzYAa

Genetic Diversity Between Mouse Strains Allows Identification of CC027/GeniUnc as an Orally Reactive Model of Peanut Allergy

This study demonstrates the use of the genetically diverse Collaborative Cross which identified an improved, orally reactive mouse model of peanut allergy, to study the etiology of food allergy and the development of new therapies. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PfwFDD

Antinuclear antibodies in Frontotemporal Dementia: the tip's of autoimmunity iceberg?

We reported a significant increase of antinuclear autoantibodies (ANA) positivity in 100 FTD patients as compared to 100 healthy controls (HC) (60% vs. 13%, p   (Source: Journal of Neuroimmunology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHhDDs

Infection burden and immunological responses are equivalent for polymeric and metallic implant materials in vitro and in a murine model of fracture ‐related infection

Journal of Biomedical Materials Research Part B: Applied Biomaterials, EarlyView. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PdoMyw

Stewart ’s Shops Issues Allergy Alert on Undeclared Milk in Cranberry Apple Refresher

Saratoga Springs, NY - Stewart 's Shops Corp. is recalling units of Stewart's Shops brand Cranberry Apple Refresher 16 fluid oz. because the product may contain undeclared milk. People who have an allergy to milk run the risk of serious or life-threatening allergic reaction if they consume this product. Approximately 2,300 u nits of affected product were distributed in upstate New York and Southern Vermont. (Source: Food and Drug Administration)

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DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment

Host injury triggers feedback mechanisms that limit tissue damage. Conventional type 1 dendritic cells (cDC1s) express dendritic cell natural killer lectin group receptor-1 (DNGR-1), encoded by the gene Clec9a, which senses tissue damage and favors cross-presentation of dead-cell material to CD8+ T cells. Here we find that DNGR-1 additionally reduces host-damaging inflammatory responses induced by sterile and infectious tissue injury in mice. DNGR-1 deficiency leads to exacerbated caerulein-induced necrotizing pancreatitis and increased pathology during systemic Candida albicans infection without affecting fungal burden. This effect is B and T cell–independent and attributable to increased neutrophilia in DNGR-1–deficient settings. Mechanistically, DNGR-1 engagement activates S...

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The absence of DNGR-1 is dangerous

(Source: ScienceNOW)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ai7nfD

Stewart ’s Shops Issues Allergy Alert on Undeclared Milk in Cranberry Apple Refresher

Saratoga Springs, NY - Stewart 's Shops Corp. is recalling units of Stewart's Shops brand Cranberry Apple Refresher 16 fluid oz. because the product may contain undeclared milk. People who have an allergy to milk run the risk of serious or life-threatening allergic reaction if they consume this product. Approximately 2,300 u nits of affected product were distributed in upstate New York and Southern Vermont. (Source: Food and Drug Administration)

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A friendly danger

(Source: ScienceNOW)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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Procurement Requirements Drive Interoperability in Health Care IT

Steps outlined for health systems to establish comprehensive, ongoing procurement strategies (Source: The Doctors Lounge - Psychiatry)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QYceb8

Use of microcatheters for suction thrombectomy of acute distal occlusions

Abstract

We report our initial experience of using a microcatheter for contact aspiration of acute distal occlusions for recanalization. Endovascular technique and a case using Excelsior XT-27 microcatheter are presented. After manual suction within distal middle cerebral artery segments using a 50-ml syringe, instant and complete recanalization was obtained. Microcatheter suction thrombectomy using a 50-ml syringe can be considered a feasible treatment option for acute distal small artery occlusions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R1LE1c

Allergy research: Test predicts outcome of hay fever therapies

(Technical University of Munich (TUM)) Allergen-specific immunotherapy can considerably improve everyday life for allergy sufferers. It is unclear, however, what exactly happens during this treatment. A team at the Technical University of Munich (TUM) and Helmholtz Zentrum M ü nchen investigated the processes taking place in the body over the course of a three-year allergen-specific immunotherapy. The researchers found clues as to why the allergy immunization takes so long and how the chances of success can be determined at a very early stage. (Source: EurekAlert! - Biology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AhGuZ4

Stewart ’s Shops Issues Allergy Alert on Undeclared Milk in Cranberry Apple Refresher

Saratoga Springs, NY - Stewart 's Shops Corp. is recalling units of Stewart's Shops brand Cranberry Apple Refresher 16 fluid oz. because the product may contain undeclared milk. People who have an allergy to milk run the risk of serious or life-threatening allergic reaction if they consume this product. Approximately 2,300 u nits of affected product were distributed in upstate New York and Southern Vermont. (Source: Food and Drug Administration)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AhISze

DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment

Host injury triggers feedback mechanisms that limit tissue damage. Conventional type 1 dendritic cells (cDC1s) express dendritic cell natural killer lectin group receptor-1 (DNGR-1), encoded by the gene Clec9a, which senses tissue damage and favors cross-presentation of dead-cell material to CD8+ T cells. Here we find that DNGR-1 additionally reduces host-damaging inflammatory responses induced by sterile and infectious tissue injury in mice. DNGR-1 deficiency leads to exacerbated caerulein-induced necrotizing pancreatitis and increased pathology during systemic Candida albicans infection without affecting fungal burden. This effect is B and T cell–independent and attributable to increased neutrophilia in DNGR-1–deficient settings. Mechanistically, DNGR-1 engagement activates S...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R0I8DV

Procurement Requirements Drive Interoperability in Health Care IT

Steps outlined for health systems to establish comprehensive, ongoing procurement strategies (Source: The Doctors Lounge - Psychiatry)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QYceb8

The absence of DNGR-1 is dangerous

(Source: ScienceNOW)

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A friendly danger

(Source: ScienceNOW)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QUHAzE

Use of microcatheters for suction thrombectomy of acute distal occlusions

Abstract

We report our initial experience of using a microcatheter for contact aspiration of acute distal occlusions for recanalization. Endovascular technique and a case using Excelsior XT-27 microcatheter are presented. After manual suction within distal middle cerebral artery segments using a 50-ml syringe, instant and complete recanalization was obtained. Microcatheter suction thrombectomy using a 50-ml syringe can be considered a feasible treatment option for acute distal small artery occlusions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R1LE1c

The absence of DNGR-1 is dangerous

(Source: ScienceNOW)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ai7nfD

Stewart ’s Shops Issues Allergy Alert on Undeclared Milk in Cranberry Apple Refresher

Saratoga Springs, NY - Stewart 's Shops Corp. is recalling units of Stewart's Shops brand Cranberry Apple Refresher 16 fluid oz. because the product may contain undeclared milk. People who have an allergy to milk run the risk of serious or life-threatening allergic reaction if they consume this product. Approximately 2,300 u nits of affected product were distributed in upstate New York and Southern Vermont. (Source: Food and Drug Administration)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AhISze

A friendly danger

(Source: ScienceNOW)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QUHAzE

Procurement Requirements Drive Interoperability in Health Care IT

Steps outlined for health systems to establish comprehensive, ongoing procurement strategies (Source: The Doctors Lounge - Psychiatry)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QYceb8

Allergy research: Test predicts outcome of hay fever therapies

(Technical University of Munich (TUM)) Allergen-specific immunotherapy can considerably improve everyday life for allergy sufferers. It is unclear, however, what exactly happens during this treatment. A team at the Technical University of Munich (TUM) and Helmholtz Zentrum M ü nchen investigated the processes taking place in the body over the course of a three-year allergen-specific immunotherapy. The researchers found clues as to why the allergy immunization takes so long and how the chances of success can be determined at a very early stage. (Source: EurekAlert! - Biology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AhGuZ4

DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment

Host injury triggers feedback mechanisms that limit tissue damage. Conventional type 1 dendritic cells (cDC1s) express dendritic cell natural killer lectin group receptor-1 (DNGR-1), encoded by the gene Clec9a, which senses tissue damage and favors cross-presentation of dead-cell material to CD8+ T cells. Here we find that DNGR-1 additionally reduces host-damaging inflammatory responses induced by sterile and infectious tissue injury in mice. DNGR-1 deficiency leads to exacerbated caerulein-induced necrotizing pancreatitis and increased pathology during systemic Candida albicans infection without affecting fungal burden. This effect is B and T cell–independent and attributable to increased neutrophilia in DNGR-1–deficient settings. Mechanistically, DNGR-1 engagement activates S...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R0I8DV

A friendly danger

(Source: ScienceNOW)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QUHAzE

Implementation and Benefits of a Vendor-Neutral Archive and Enterprise-Imaging Management System in an Integrated Delivery Network

Abstract

The use of digital imaging has substantially grown in recent decades, in traditional services, new specialties, and departments. The need to share these data among departments and caregivers necessitated central archiving systems that are able to communicate with various viewing applications and electronic medical records. This promoted the development of modern vendor neutral archive (VNA) systems. The need to aggregate and share imaging data from various departments promoted the development of enterprise-imaging (EI) solutions that replace departmental silos of data with central healthcare enterprise databases. To describe the implementation process of a VNA-EI solution in a large health system and its outcomes. We review the background of VNA and EI solutions development and describe the characteristics and advantages of such systems. We then describe our experience in implementation of these solutions in a large integrated healthcare delivery network in northeast Ohio. We then present the process, challenges, costs, advantages, and outcomes of such implementation. The VNA and EI solution was launched in December 2015 and is still ongoing. It currently includes 54 radiology and 26 cardiology sites affiliated with the University Hospitals health system. This process was associated with more than 10% cost savings, 30% reduction in storage costs, superior support for disaster recovery, and 80% decrease in unscheduled outages. All these were achieved despite a 120% increase in archive retrieval needs and a 40% growth in image production. Implementation of a VNA and EI solution was successful and resulted in numerous measurable and qualitative improvements in a large and growing health system.

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Automatic Lumbar MRI Detection and Identification Based on Deep Learning

Abstract

The aim of this research is to automatically detect lumbar vertebras in MRI images with bounding boxes and their classes, which can assist clinicians with diagnoses based on large amounts of MRI slices. Vertebras are highly semblable in appearance, leading to a challenging automatic recognition. A novel detection algorithm is proposed in this paper based on deep learning. We apply a similarity function to train the convolutional network for lumbar spine detection. Instead of distinguishing vertebras using annotated lumbar images, our method compares similarities between vertebras using a beforehand lumbar image. In the convolutional neural network, a contrast object will not update during frames, which allows a fast speed and saves memory. Due to its distinctive shape, S1 is firstly detected and a rough region around it is extracted for searching for L1–L5. The results are evaluated with accuracy, precision, mean, and standard deviation (STD). Finally, our detection algorithm achieves the accuracy of 98.6% and the precision of 98.9%. Most failed results are involved with wrong S1 locations or missed L5. The study demonstrates that a lumbar detection network supported by deep learning can be trained successfully without annotated MRI images. It can be believed that our detection method will assist clinicians to raise working efficiency.

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Comprehensive Word-Level Classification of Screening Mammography Reports Using a Neural Network Sequence Labeling Approach

Abstract

Radiology reports contain a large amount of potentially valuable unstructured data. Recently, neural networks have been employed to perform classification of radiology reports over a few classes at the document level. The success of neural networks in sequence-labeling problems such as named entity recognition and part of speech tagging suggests that they could be used to classify radiology report text with greater granularity. We employed a neural network architecture to comprehensively classify mammography report text at the word level using a sequence labeling approach. Two radiologists devised a comprehensive classification system for screening mammography reports. Each word in each report was manually categorized by a radiologist into one of 33 categories according to the classification system. Tagged words referencing the same finding were grouped into unique sets. We pre-labeled reports with a rule-based algorithm and then manually edited these annotations for 6705 screening mammography reports (25.1%, 66.8%, and 8.1% BI-RADS 0, 1, and 2, respectively). A combined convolutional and recurrent neural network model was used to label words in each sentence of the individual reports. A siamese recurrent neural network was then used to group findings into sets. Performance of the neural network-based method was compared to a rule-based algorithm and a conditional random field (CRF) model. Global accuracy (percentage of documents where all word tags were predicted correctly) and keyword accuracy (percentage of all words that were labeled correctly, excluding words tagged as unimportant) were calculated on an unseen 519 report test set. Two-tailed t tests were used to assess differences between algorithm performance, and p < 0.05 was used to determine statistical significance. The neural network-based approach showed significantly higher global accuracy compared to both the rule-based algorithm (88.3 vs 57.0%, p < 0.001) and the CRF model (88.3% vs. 75.8%, p < 0.001). The neural network also showed significantly higher keyword level accuracy compared to the rule-based algorithm (95.5% vs. 80.9% p < 0.001) and CRF model (95.5% vs. 76.9%, p < 0.001). We demonstrate the potential of neural networks to accurately perform word-level multilabel classification of free text radiology reports across 33 classes, thus showing the utility of a sequence labeling approach to NLP of radiology reports. We found that a neural network classifier outperforms a rule-based algorithm and a CRF classifier for comprehensive multilabel classification of free text screening mammography reports at the word level. By approaching radiology report classification as a sequence-labeling problem, we demonstrate the ability of neural networks to extract data from free text radiology reports at a level of granularity not previously reported.

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A comparison of conventional and diffusion-weighted magnetic resonance imaging in the diagnosis of sialadenitis and pleomorphic adenoma

Objectives: To compare the efficacy of conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in helping observers correctly identify the presence of disease in the major salivary glands and correctly distinguish sialadenitis from pleomorphic adenoma.Study design: Twenty-one patients diagnosed with unilateral sialadenitis or pleomorphic adenoma were selected. The non-affected contralateral glands were also analyzed. T1- and T2-weighted MRI and DWI were obtained using spin-echo (SE) pulse sequences with a 1.5 Tesla MRI device.

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Comparison of mandibular index values determined from standard panoramic versus CBCT reconstructed images

To compare the mandibular index values including mandibular cortical index (MCI), mental index(MI), and panoramic mandibular index (PMI) determined from cone-beam computed tomography(CBCT) and panoramic images.

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Implementation and Benefits of a Vendor-Neutral Archive and Enterprise-Imaging Management System in an Integrated Delivery Network

Abstract

The use of digital imaging has substantially grown in recent decades, in traditional services, new specialties, and departments. The need to share these data among departments and caregivers necessitated central archiving systems that are able to communicate with various viewing applications and electronic medical records. This promoted the development of modern vendor neutral archive (VNA) systems. The need to aggregate and share imaging data from various departments promoted the development of enterprise-imaging (EI) solutions that replace departmental silos of data with central healthcare enterprise databases. To describe the implementation process of a VNA-EI solution in a large health system and its outcomes. We review the background of VNA and EI solutions development and describe the characteristics and advantages of such systems. We then describe our experience in implementation of these solutions in a large integrated healthcare delivery network in northeast Ohio. We then present the process, challenges, costs, advantages, and outcomes of such implementation. The VNA and EI solution was launched in December 2015 and is still ongoing. It currently includes 54 radiology and 26 cardiology sites affiliated with the University Hospitals health system. This process was associated with more than 10% cost savings, 30% reduction in storage costs, superior support for disaster recovery, and 80% decrease in unscheduled outages. All these were achieved despite a 120% increase in archive retrieval needs and a 40% growth in image production. Implementation of a VNA and EI solution was successful and resulted in numerous measurable and qualitative improvements in a large and growing health system.

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Automatic Lumbar MRI Detection and Identification Based on Deep Learning

Abstract

The aim of this research is to automatically detect lumbar vertebras in MRI images with bounding boxes and their classes, which can assist clinicians with diagnoses based on large amounts of MRI slices. Vertebras are highly semblable in appearance, leading to a challenging automatic recognition. A novel detection algorithm is proposed in this paper based on deep learning. We apply a similarity function to train the convolutional network for lumbar spine detection. Instead of distinguishing vertebras using annotated lumbar images, our method compares similarities between vertebras using a beforehand lumbar image. In the convolutional neural network, a contrast object will not update during frames, which allows a fast speed and saves memory. Due to its distinctive shape, S1 is firstly detected and a rough region around it is extracted for searching for L1–L5. The results are evaluated with accuracy, precision, mean, and standard deviation (STD). Finally, our detection algorithm achieves the accuracy of 98.6% and the precision of 98.9%. Most failed results are involved with wrong S1 locations or missed L5. The study demonstrates that a lumbar detection network supported by deep learning can be trained successfully without annotated MRI images. It can be believed that our detection method will assist clinicians to raise working efficiency.

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Comprehensive Word-Level Classification of Screening Mammography Reports Using a Neural Network Sequence Labeling Approach

Abstract

Radiology reports contain a large amount of potentially valuable unstructured data. Recently, neural networks have been employed to perform classification of radiology reports over a few classes at the document level. The success of neural networks in sequence-labeling problems such as named entity recognition and part of speech tagging suggests that they could be used to classify radiology report text with greater granularity. We employed a neural network architecture to comprehensively classify mammography report text at the word level using a sequence labeling approach. Two radiologists devised a comprehensive classification system for screening mammography reports. Each word in each report was manually categorized by a radiologist into one of 33 categories according to the classification system. Tagged words referencing the same finding were grouped into unique sets. We pre-labeled reports with a rule-based algorithm and then manually edited these annotations for 6705 screening mammography reports (25.1%, 66.8%, and 8.1% BI-RADS 0, 1, and 2, respectively). A combined convolutional and recurrent neural network model was used to label words in each sentence of the individual reports. A siamese recurrent neural network was then used to group findings into sets. Performance of the neural network-based method was compared to a rule-based algorithm and a conditional random field (CRF) model. Global accuracy (percentage of documents where all word tags were predicted correctly) and keyword accuracy (percentage of all words that were labeled correctly, excluding words tagged as unimportant) were calculated on an unseen 519 report test set. Two-tailed t tests were used to assess differences between algorithm performance, and p < 0.05 was used to determine statistical significance. The neural network-based approach showed significantly higher global accuracy compared to both the rule-based algorithm (88.3 vs 57.0%, p < 0.001) and the CRF model (88.3% vs. 75.8%, p < 0.001). The neural network also showed significantly higher keyword level accuracy compared to the rule-based algorithm (95.5% vs. 80.9% p < 0.001) and CRF model (95.5% vs. 76.9%, p < 0.001). We demonstrate the potential of neural networks to accurately perform word-level multilabel classification of free text radiology reports across 33 classes, thus showing the utility of a sequence labeling approach to NLP of radiology reports. We found that a neural network classifier outperforms a rule-based algorithm and a CRF classifier for comprehensive multilabel classification of free text screening mammography reports at the word level. By approaching radiology report classification as a sequence-labeling problem, we demonstrate the ability of neural networks to extract data from free text radiology reports at a level of granularity not previously reported.

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A comparison of conventional and diffusion-weighted magnetic resonance imaging in the diagnosis of sialadenitis and pleomorphic adenoma

Objectives: To compare the efficacy of conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in helping observers correctly identify the presence of disease in the major salivary glands and correctly distinguish sialadenitis from pleomorphic adenoma.Study design: Twenty-one patients diagnosed with unilateral sialadenitis or pleomorphic adenoma were selected. The non-affected contralateral glands were also analyzed. T1- and T2-weighted MRI and DWI were obtained using spin-echo (SE) pulse sequences with a 1.5 Tesla MRI device.

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Panoramic Radiographs are of Limited Value in the Evaluation of Maxillary Sinus Disease

To determine: 1) the diagnostic efficacy of orthopantomography (OPG) in the diagnosis of sinus diseases, using cone beam CT (CBCT) scanning as the imaging gold standard; 2) which diseases were detected by panoramic radiograph and which required CBCT scanning to make the diagnosis; and 3) the inter-observer agreement of two experienced dental radiologists.

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Comparison of mandibular index values determined from standard panoramic versus CBCT reconstructed images

To compare the mandibular index values including mandibular cortical index (MCI), mental index(MI), and panoramic mandibular index (PMI) determined from cone-beam computed tomography(CBCT) and panoramic images.

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Genetic Diversity Between Mouse Strains Allows Identification of CC027/GeniUnc as an Orally Reactive Model of Peanut Allergy

This study demonstrates the use of the genetically diverse Collaborative Cross which identified an improved, orally reactive mouse model of peanut allergy, to study the etiology of food allergy and the development of new therapies.

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Validation of the maximum symptom day among children with asthma

The maximum symptom day, a primary outcome of inner-city asthma research for almost two decades, is a valid measure that consistently relates to asthma control and is predictive of clinically relevant asthma endpoints.

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Genetic Diversity Between Mouse Strains Allows Identification of CC027/GeniUnc as an Orally Reactive Model of Peanut Allergy

This study demonstrates the use of the genetically diverse Collaborative Cross which identified an improved, orally reactive mouse model of peanut allergy, to study the etiology of food allergy and the development of new therapies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AhP0ri

Validation of the maximum symptom day among children with asthma

The maximum symptom day, a primary outcome of inner-city asthma research for almost two decades, is a valid measure that consistently relates to asthma control and is predictive of clinically relevant asthma endpoints.

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Phonological Development in a Bilingual Arabic-English-Speaking Child With Bilateral Cochlear Implants: A Longitudinal Case Study.

Conclusion: Bilingual children with CIs have the capability to learn both of their languages and perform similarly to, and even surpass in accuracy, monolingual children with CIs; however, it is also possible to exhibit a slower rate of acquisition of segmental accuracy as compared to their typically developing, hearing peers. Clinical implications of bilingual early intervention are discussed. PMID: 30326047 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

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Phonological Development in a Bilingual Arabic-English-Speaking Child With Bilateral Cochlear Implants: A Longitudinal Case Study.

Conclusion: Bilingual children with CIs have the capability to learn both of their languages and perform similarly to, and even surpass in accuracy, monolingual children with CIs; however, it is also possible to exhibit a slower rate of acquisition of segmental accuracy as compared to their typically developing, hearing peers. Clinical implications of bilingual early intervention are discussed. PMID: 30326047 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

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Long-term quality of life outcomes of maxillomandibular advancement osteotomy in patients with obstructive sleep apnoea syndrome

This study was performed to evaluate the long-term impact of maxillomandibular advancement (MMA) surgery on the apnoea–hypopnoea index (AHI) and quality of life (QoL) in patients with obstructive sleep apnoea syndrome (OSAS). The medical files of 12 OSAS patients who underwent MMA by one surgeon between 1995 and 1999 were reviewed retrospectively. Patients received a clinical assessment, polysomnography, and QoL questionnaires as part of routine care preoperatively (n=12), within 2 years postoperative (n=12), and again in 2016 (n=9).

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Long-term quality of life outcomes of maxillomandibular advancement osteotomy in patients with obstructive sleep apnoea syndrome

This study was performed to evaluate the long-term impact of maxillomandibular advancement (MMA) surgery on the apnoea–hypopnoea index (AHI) and quality of life (QoL) in patients with obstructive sleep apnoea syndrome (OSAS). The medical files of 12 OSAS patients who underwent MMA by one surgeon between 1995 and 1999 were reviewed retrospectively. Patients received a clinical assessment, polysomnography, and QoL questionnaires as part of routine care preoperatively (n=12), within 2 years postoperative (n=12), and again in 2016 (n=9).

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Challenging moments as opportunities to learn: The role of nonverbal interactional resources in dealing with conflicts in English as a lingua franca classroom interactions

This study sequentially analyzes interactional conflicts among students and instructors in writing classrooms at a U.S. university in which English functions as a lingua franca, highlighting how students from various linguistic and cultural backgrounds employ nonverbal interactional resources (e.g., silence, gaze, and gesture) along with speech when disagreeing and/or disengaging. The consensus-oriented and cooperative aspects of English as a lingua franca (ELF) interactions have been widely documented (e.g., Mauranen, 2012, Seidlhofer, 2001), but recent research (e.g., Jenks, 2012) has started to illuminate aspects of uncooperativeness in various ELF interactional contexts. Using sequential, multimodal analysis, this study illustrates how students effectively coordinate various nonverbal ...

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Synthesis, characterization and unravelling the molecular interaction of new bioactive 4-hydroxycoumarin derivative with biopolymer: Insights from spectroscopic and theoretical aspect

Publication date: December 2018Source: Journal of Photochemistry and Photobiology B: Biology, Volume 189Author(s): Abhijit Mukherjee, Suvranil Ghosh, Rudraditya Sarkar, Satyajit Samanta, Sudipta Ghosh, Mahadeb Pal, Adinath Majee, Sukanta Kumar Sen, Bula SinghAbstractIn the progress of small molecule as drug candidates, 4-hydroxycoumarin based compounds bearing a crucial place as potent antibiotic agents with appreciable safety in drug invention. Being synthetically and easily obtainable, 4-hydroxycoumarin related compounds with planar structure have been promoted predominantly as DNA targeting agent. Nevertheless, here we elucidate the synthesis, characterization and theoretical study of bio-active small molecule 4-hydroxy-3,4′-bichromenyl-2,2′-dione (4HBD). Then we have illuminated th...

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Ameliorative effect of berberine coated bio-active nanoparticles in acetaminophen induced hepato-renal damage in diabetic rats

Publication date: Available online 17 October 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Yueyue Wu, Xinmei Huang, Min Yang, Jiong Xu, Zaoping Chen, Zhiyan Yu, Jun LiuAbstractThe current investigation was performed for the detailed analysis of protective effect of biofabricate berberine coated nano‑silver ameliorate (BBR-AgNPs) on acetaminophen (APAP) induced hepato-renal damages in diabetic rats by blood biochemistry, tissue biochemistry, histopathological and immunohistochemical analysis. The spherical shaped BBR-AgNPs were synthesized by the Biofabrication technique and its physico-chemical characterizations done by different spectroscopic (UV–vis spectrophotometer, XRD spectroscopy, FTIR spectroscopy EDAX & DLS analyses) and microscopic (FE-SEM) tech...

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Acquiring a first language in adolescence: the case of basic word order in American Sign Language.

Authors: Cheng Q, Mayberry RI Abstract Previous studies suggest that age of acquisition affects the outcomes of learning, especially at the morphosyntactic level. Unknown is how syntactic development is affected by increased cognitive maturity and delayed language onset. The current paper studied the early syntactic development of adolescent first language learners by examining word order patterns in American Sign Language (ASL). ASL uses a basic Subject-Verb-Object order, but also employs multiple word order variations. Child learners produce variable word order at the initial stage of acquisition, but later primarily produce canonical word order. We asked whether adolescent first language learners acquire ASL word order in a fashion parallel to child learners. We analyzed word or...

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Exposure and feedback in language acquisition: adult construals of children's early verb-form use in Hebrew.

This study focuses on adult responses to children's verb uses, the information they provide, and how they change over time. We analyzed longitudinal samples from four children acquiring Hebrew (age-range: 1;4-2;5; child verb-forms = 8,337). All child verbs were coded for inflectional category, and for whether and how adults responded to them. Our findings show that: (a) children's early verbs were opaque with no clear inflectional target (e.g., the child-form tapes corresponds to letapes 'to-climb', metapes 'is-climbing', yetapes 'will-climb'), with inflections added gradually; (b) most early verbs were followed by adult responses using the same lexeme; and (c) as opacity in children's verbs decreased, adults made fewer uses of the same lexeme in their responses, and produced a broader arr...

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The effect of neighborhood density on children's word learning in noise.

Authors: Han MK, Storkel H, Bontempo DE Abstract Many studies have addressed the effect of neighborhood density (phonological similarity among words) on word learning in quiet listening conditions. We explored how noise influences the effect of neighborhood density on children's word learning. One-hundred-and-two preschoolers learned nonwords varied in neighborhood density in one of four listening conditions: quiet, +15 dB signal-to-noise ratio (SNR), +6 dB SNR, and 0 dB SNR. Results showed that a high-density advantage for children under quiet listening condition was significantly reduced as noise increased. This finding implies an adverse impact of noise on long-term outcomes of word learning. PMID: 30322424 [PubMed - as supplied by publisher] (Source: Journal of Child Langua...

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Correction.

CORRECTION. Clin Linguist Phon. 2018 Oct 16;:1 Authors: PMID: 30325239 [PubMed - as supplied by publisher] (Source: Clinical Linguistics and Phonetics)

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Phonological Development in a Bilingual Arabic-English-Speaking Child With Bilateral Cochlear Implants: A Longitudinal Case Study.

Conclusion: Bilingual children with CIs have the capability to learn both of their languages and perform similarly to, and even surpass in accuracy, monolingual children with CIs; however, it is also possible to exhibit a slower rate of acquisition of segmental accuracy as compared to their typically developing, hearing peers. Clinical implications of bilingual early intervention are discussed. PMID: 30326047 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J5kVO9

Challenging moments as opportunities to learn: The role of nonverbal interactional resources in dealing with conflicts in English as a lingua franca classroom interactions

This study sequentially analyzes interactional conflicts among students and instructors in writing classrooms at a U.S. university in which English functions as a lingua franca, highlighting how students from various linguistic and cultural backgrounds employ nonverbal interactional resources (e.g., silence, gaze, and gesture) along with speech when disagreeing and/or disengaging. The consensus-oriented and cooperative aspects of English as a lingua franca (ELF) interactions have been widely documented (e.g., Mauranen, 2012, Seidlhofer, 2001), but recent research (e.g., Jenks, 2012) has started to illuminate aspects of uncooperativeness in various ELF interactional contexts. Using sequential, multimodal analysis, this study illustrates how students effectively coordinate various nonverbal ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOGIdY

Synthesis, characterization and unravelling the molecular interaction of new bioactive 4-hydroxycoumarin derivative with biopolymer: Insights from spectroscopic and theoretical aspect

Publication date: December 2018Source: Journal of Photochemistry and Photobiology B: Biology, Volume 189Author(s): Abhijit Mukherjee, Suvranil Ghosh, Rudraditya Sarkar, Satyajit Samanta, Sudipta Ghosh, Mahadeb Pal, Adinath Majee, Sukanta Kumar Sen, Bula SinghAbstractIn the progress of small molecule as drug candidates, 4-hydroxycoumarin based compounds bearing a crucial place as potent antibiotic agents with appreciable safety in drug invention. Being synthetically and easily obtainable, 4-hydroxycoumarin related compounds with planar structure have been promoted predominantly as DNA targeting agent. Nevertheless, here we elucidate the synthesis, characterization and theoretical study of bio-active small molecule 4-hydroxy-3,4′-bichromenyl-2,2′-dione (4HBD). Then we have illuminated th...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pZQXmh

Ameliorative effect of berberine coated bio-active nanoparticles in acetaminophen induced hepato-renal damage in diabetic rats

Publication date: Available online 17 October 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Yueyue Wu, Xinmei Huang, Min Yang, Jiong Xu, Zaoping Chen, Zhiyan Yu, Jun LiuAbstractThe current investigation was performed for the detailed analysis of protective effect of biofabricate berberine coated nano‑silver ameliorate (BBR-AgNPs) on acetaminophen (APAP) induced hepato-renal damages in diabetic rats by blood biochemistry, tissue biochemistry, histopathological and immunohistochemical analysis. The spherical shaped BBR-AgNPs were synthesized by the Biofabrication technique and its physico-chemical characterizations done by different spectroscopic (UV–vis spectrophotometer, XRD spectroscopy, FTIR spectroscopy EDAX & DLS analyses) and microscopic (FE-SEM) tech...

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The acquisition of English possessives by a bilingual child: Do input and usage frequency matter?

This study tests whether input or usage frequency predicts the order of acquisition and accuracy of a bilingual Greek-English child's English possessives. The child was followed longitudinally from age 2;6 to 3;11. Order of acquisition was comparable to that of same-aged monolingual children. The child's usage frequency and order of acquisition were highly correlated with input frequency, while her accuracy was not. We argue that the child's already-acquired Greek possessives facilitated acquisition of English possessives, even though the child's English input and usage frequencies were lower than in monolingual English children. PMID: 30326984 [PubMed - as supplied by publisher] (Source: Journal of Child Language)

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Acquiring a first language in adolescence: the case of basic word order in American Sign Language.

Authors: Cheng Q, Mayberry RI Abstract Previous studies suggest that age of acquisition affects the outcomes of learning, especially at the morphosyntactic level. Unknown is how syntactic development is affected by increased cognitive maturity and delayed language onset. The current paper studied the early syntactic development of adolescent first language learners by examining word order patterns in American Sign Language (ASL). ASL uses a basic Subject-Verb-Object order, but also employs multiple word order variations. Child learners produce variable word order at the initial stage of acquisition, but later primarily produce canonical word order. We asked whether adolescent first language learners acquire ASL word order in a fashion parallel to child learners. We analyzed word or...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOGFyO

Exposure and feedback in language acquisition: adult construals of children's early verb-form use in Hebrew.

This study focuses on adult responses to children's verb uses, the information they provide, and how they change over time. We analyzed longitudinal samples from four children acquiring Hebrew (age-range: 1;4-2;5; child verb-forms = 8,337). All child verbs were coded for inflectional category, and for whether and how adults responded to them. Our findings show that: (a) children's early verbs were opaque with no clear inflectional target (e.g., the child-form tapes corresponds to letapes 'to-climb', metapes 'is-climbing', yetapes 'will-climb'), with inflections added gradually; (b) most early verbs were followed by adult responses using the same lexeme; and (c) as opacity in children's verbs decreased, adults made fewer uses of the same lexeme in their responses, and produced a broader arr...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q7rxmR

The effect of neighborhood density on children's word learning in noise.

Authors: Han MK, Storkel H, Bontempo DE Abstract Many studies have addressed the effect of neighborhood density (phonological similarity among words) on word learning in quiet listening conditions. We explored how noise influences the effect of neighborhood density on children's word learning. One-hundred-and-two preschoolers learned nonwords varied in neighborhood density in one of four listening conditions: quiet, +15 dB signal-to-noise ratio (SNR), +6 dB SNR, and 0 dB SNR. Results showed that a high-density advantage for children under quiet listening condition was significantly reduced as noise increased. This finding implies an adverse impact of noise on long-term outcomes of word learning. PMID: 30322424 [PubMed - as supplied by publisher] (Source: Journal of Child Langua...

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Correction.

CORRECTION. Clin Linguist Phon. 2018 Oct 16;:1 Authors: PMID: 30325239 [PubMed - as supplied by publisher] (Source: Clinical Linguistics and Phonetics)

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Phonological Development in a Bilingual Arabic-English-Speaking Child With Bilateral Cochlear Implants: A Longitudinal Case Study.

Conclusion: Bilingual children with CIs have the capability to learn both of their languages and perform similarly to, and even surpass in accuracy, monolingual children with CIs; however, it is also possible to exhibit a slower rate of acquisition of segmental accuracy as compared to their typically developing, hearing peers. Clinical implications of bilingual early intervention are discussed. PMID: 30326047 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

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Deafness could be reversed? Scientists discover how to regrow lost cells in the ear

Researchers from the University of Rochester found that viruses, genetics and even existing drugs could cause little hairs to regrow in the inner ear. These hairs pick up on noises entering the ear. (Source: the Mail online | Health)

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Deafness could be reversed? Scientists discover how to regrow lost cells in the ear

Researchers from the University of Rochester found that viruses, genetics and even existing drugs could cause little hairs to regrow in the inner ear. These hairs pick up on noises entering the ear. (Source: the Mail online | Health)

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Deafness could be reversed? Scientists discover how to regrow lost cells in the ear

Researchers from the University of Rochester found that viruses, genetics and even existing drugs could cause little hairs to regrow in the inner ear. These hairs pick up on noises entering the ear. (Source: the Mail online | Health)

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Deafness could be reversed? Scientists discover how to regrow lost cells in the ear

Researchers from the University of Rochester found that viruses, genetics and even existing drugs could cause little hairs to regrow in the inner ear. These hairs pick up on noises entering the ear. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Phonological Development in a Bilingual Arabic-English-Speaking Child With Bilateral Cochlear Implants: A Longitudinal Case Study.

Conclusion: Bilingual children with CIs have the capability to learn both of their languages and perform similarly to, and even surpass in accuracy, monolingual children with CIs; however, it is also possible to exhibit a slower rate of acquisition of segmental accuracy as compared to their typically developing, hearing peers. Clinical implications of bilingual early intervention are discussed. PMID: 30326047 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

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[Diffuse esophageal leiomyomatosis and Alport's syndrome: A case report and review of the literature].

Authors: Delteil C, Macagno N, Daniel L, D'Journo XB, Guisiano S, Garcia S, Secq V Abstract Diffuse esophageal leiomyomatosis is a rare esophageal tumor characterized by circumferential thickening of smooth muscle layers. Diffuse esophageal leiomyomatosis can be associated with Alport's syndrome and therefore diagnosed by skin biopsy. Alport syndrome is a hereditary disease usually defined by the association of glomerular nephropathy and perceptual deafness. Here we describe the management of a young women with a diffuse esophageal leiomyomatosis and a past history of uterine leiomyoma. The surgical treatment depends on the esophageal extent of the disease. Association between diffuse esophageal leiomyomatosis and early uterine leiomyomas could be also observed and leading to Alpor...

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Baseline patient factors impact on the clinical efficacy of benralizumab for severe asthma

Benralizumab is an anti-eosinophilic monoclonal antibody that reduces exacerbations and improves lung function for patients with severe, uncontrolled asthma with eosinophilic inflammation. We evaluated the impact of baseline factors on benralizumab efficacy for patients with severe asthma. This analysis used pooled data from the SIROCCO (ClinicalTrials.gov identifier NCT01928771) and CALIMA (ClinicalTrials.gov identifier NCT01914757) Phase III studies. Patients aged 12–75 years with severe, uncontrolled asthma receiving high-dosage inhaled corticosteroids plus long-acting β2-agonists received benralizumab 30 mg subcutaneously every 8 weeks (Q8W, first three doses every 4 weeks (Q4W)), Q4W or placebo. Baseline factors that influenced benralizumab efficacy were...

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Self-assembling Insect Ferritin Nanoparticles for Display of Co-assembled Trimeric Antigens

Antigens on the surface of virus particles are displayed in a regular, repetitive pattern which facilitates B cell activation. Presenting trimeric antigens on engineered particles that mimic the geometric patterns observed for native viral proteins can lead to an improved host antibody response.Self-assembling globular ferritin nanoparticles have previously been used to display multiple copies of a co-assembled trimeric antigen to the immune system. However, prior ferritin nanoparticle technologies only permit a random co-assembly of diverse trimeric antigens, and therefore cannot guarantee the pattern and ratio of diverse trimeric antigens on a single ferritin nanoparticle.Researchers at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases are dev...

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HIV-1 Env Fusion Peptide Immunogens and Their Use

Millions of people are infected with HIV-1 worldwide, and 2.5 to 3 million new infections have been estimated to occur yearly. Although effective antiretroviral therapies are available, millions succumb to AIDS every year, especially in Sub-Saharan Africa, underscoring the need to develop measures to prevent the spread of this disease.HIV-1 is an enveloped virus, which hides from humoral recognition behind a wide array of protective mechanisms. During infection, the major envelope protein of HIV-1 is cleaved by host cell proteases into two smaller versions (gp120 and gp41). Together gp120 and gp41 make up the HIV-1 Env spike, which is a target for neutralizing antibodies. It is believed that immunization with an effective immunogen based on the HIV-1 Env glycoprotein can elicit a neutraliz...

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