Self-assembling Insect Ferritin Nanoparticles for Display of Co-assembled Trimeric Antigens

Antigens on the surface of virus particles are displayed in a regular, repetitive pattern which facilitates B cell activation. Presenting trimeric antigens on engineered particles that mimic the geometric patterns observed for native viral proteins can lead to an improved host antibody response.Self-assembling globular ferritin nanoparticles have previously been used to display multiple copies of a co-assembled trimeric antigen to the immune system. However, prior ferritin nanoparticle technologies only permit a random co-assembly of diverse trimeric antigens, and therefore cannot guarantee the pattern and ratio of diverse trimeric antigens on a single ferritin nanoparticle.Researchers at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases are dev...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CpIEr7