Fluorescent imidazole-based chemosensors for the reversible detection of cyanide and mercury ions

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00226F, Paper

Ganapathi Emandi, Keith Flanagan, Mathias O Senge
We report 4-(2-(5-(tert-butyl)-3-formyl-2-hydroxyphenyl)-1H-phenanthro[9,10-d]imidazol-1-yl)benzoic acid 1 and 4-(2-(5-(tert-butyl)-3-formyl-2-hydroxyphenyl)-4,5-diphenyl-1H-imidazol-1-yl)benzoic acids 2 as reversible luminescent sensors for the detection of cyanide and mercury ions. These imidazole derivatives were characterized using spectroscopic techniques and...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Fluorescent imidazole-based chemosensors for the reversible detection of cyanide and mercury ions

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00226F, Paper

Ganapathi Emandi, Keith Flanagan, Mathias O Senge
We report 4-(2-(5-(tert-butyl)-3-formyl-2-hydroxyphenyl)-1H-phenanthro[9,10-d]imidazol-1-yl)benzoic acid 1 and 4-(2-(5-(tert-butyl)-3-formyl-2-hydroxyphenyl)-4,5-diphenyl-1H-imidazol-1-yl)benzoic acids 2 as reversible luminescent sensors for the detection of cyanide and mercury ions. These imidazole derivatives were characterized using spectroscopic techniques and...
The content of this RSS Feed (c) The Royal Society of Chemistry

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What Is Mucus?

Title: What Is Mucus?Category: Diseases and ConditionsCreated: 3/2/2016 12:00:00 AMLast Editorial Review: 8/30/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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What Is Mucus?

Title: What Is Mucus?Category: Diseases and ConditionsCreated: 3/2/2016 12:00:00 AMLast Editorial Review: 8/30/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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New edition of thyroid cancer staging system shows better prediction of survival

New edition of thyroid cancer staging system shows better prediction of survival  HealioFull coverage

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New edition of thyroid cancer staging system shows better prediction of survival

New edition of thyroid cancer staging system shows better prediction of survival  HealioFull coverage

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A Statistical View of the World Head and Neck Cancer Market With Tables and Figures | Datasheets 2018-2023

A Statistical View of the World Head and Neck Cancer Market With Tables and Figures | Datasheets 2018-2023  News Australia TodayFull coverage

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Vertigo triggered by coughing or noises

Vertigo triggered by coughing or noises  The Daily TimesFull coverage

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Head and neck cancer: A major disease burden

Head and neck cancer: A major disease burden  Himalayan TimesFull coverage

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A Statistical View of the World Head and Neck Cancer Market With Tables and Figures | Datasheets 2018-2023

A Statistical View of the World Head and Neck Cancer Market With Tables and Figures | Datasheets 2018-2023  News Australia TodayFull coverage

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Vertigo triggered by coughing or noises

Vertigo triggered by coughing or noises  The Daily TimesFull coverage

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Head and neck cancer: A major disease burden

Head and neck cancer: A major disease burden  Himalayan TimesFull coverage

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Assessing utility values for treatment-related health states of acute myeloid leukemia in the United States

Preference valuations of health status are essential in health technology and economic appraisal. This study estimated utilities for treatment-related health states of acute myeloid leukemia (AML) and disutili...

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Development and validation of a new instrument to measure perceived risks associated with the use of tobacco and nicotine-containing products

Making tobacco products associated with lower risks available to smokers who would otherwise continue smoking is recognized as an important strategy towards addressing smoking-related harm. Predicting use beha...

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Assessing utility values for treatment-related health states of acute myeloid leukemia in the United States

Preference valuations of health status are essential in health technology and economic appraisal. This study estimated utilities for treatment-related health states of acute myeloid leukemia (AML) and disutili...

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Development and validation of a new instrument to measure perceived risks associated with the use of tobacco and nicotine-containing products

Making tobacco products associated with lower risks available to smokers who would otherwise continue smoking is recognized as an important strategy towards addressing smoking-related harm. Predicting use beha...

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Punk-Rocker-Turned-Audiologist Protects Musicians ’ Hearing

Audiologist Anthony Kovacs understands the hearing dangers of being a musician. Before he began spending his days protecting peoples' hearing, he put his own at risk. Kovacs sang with punk band Shot Baker—he still performs and records with them occasionally—and worked at live music venues when he wasn't on stage. Now he focuses his full-time practice on treating people with tinnitus. He still goes to music festivals and performances, but usually as more than an audience member. Last month he took a group of audiology students from his alma mater—University of Northern Colorado—to the Bohemian Nights festival. The group spent their time fitting performers, stagehands, venue crew, sound engineers and others working the festival with custom earplugs. Working in an unregulated ind...

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Punk-Rocker-Turned-Audiologist Protects Musicians ’ Hearing

Audiologist Anthony Kovacs understands the hearing dangers of being a musician. Before he began spending his days protecting peoples' hearing, he put his own at risk. Kovacs sang with punk band Shot Baker—he still performs and records with them occasionally—and worked at live music venues when he wasn't on stage. Now he focuses his full-time practice on treating people with tinnitus. He still goes to music festivals and performances, but usually as more than an audience member. Last month he took a group of audiology students from his alma mater—University of Northern Colorado—to the Bohemian Nights festival. The group spent their time fitting performers, stagehands, venue crew, sound engineers and others working the festival with custom earplugs. Working in an unregulated ind...

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Punk-Rocker-Turned-Audiologist Protects Musicians ’ Hearing

Audiologist Anthony Kovacs understands the hearing dangers of being a musician. Before he began spending his days protecting peoples' hearing, he put his own at risk. Kovacs sang with punk band Shot Baker—he still performs and records with them occasionally—and worked at live music venues when he wasn't on stage. Now he focuses his full-time practice on treating people with tinnitus. He still goes to music festivals and performances, but usually as more than an audience member. Last month he took a group of audiology students from his alma mater—University of Northern Colorado—to the Bohemian Nights festival. The group spent their time fitting performers, stagehands, venue crew, sound engineers and others working the festival with custom earplugs. Working in an unregulated ind...

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Enteroaggregative Escherichia coli.

Authors: Jenkins C Abstract Enteroaggregative Escherichia coli (EAEC, formerly known as "EAggEC") cause acute or persistent watery diarrhoea (with or without mucus) in children, predominantly in low-income countries, and are associated with travellers' diarrhoea in children and adults in middle and high income countries. The diverse nature of EAEC is such that not all strains cause disease. Conversely, certain strains of EAEC possess additional virulence determinants associated with the ability to cause severe diarrhoea and other symptoms, which might be life-threatening in vulnerable patients. The EAEC virulence factors described to date are either encoded on the large virulence plasmid of EAEC (plasmid of aggregative adherence) or on pathogenicity islands on the chromosome. Testi...

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Human Organotypic Models for Anti-infective Research.

Authors: Hendriks A, Cruz AR, Soldaini E, Manetti AGO, Bagnoli F Abstract The use of human organotypic models for biomedical research is experiencing a significant increase due to their biological relevance, the possibility to perform high-throughput analyses, and their cost efficiency. In the field of anti-infective research, comprising the search for novel antipathogenic treatments including vaccines, efforts have been made to reduce the use of animal models. That is due to two main reasons: unreliability of data obtained with animal models and the increasing willingness to reduce the use of animals in research for ethical reasons. Human three-dimensional (3-D) models may substitute and/or complement in vivo studies, to increase the translational value of preclinical data. Here, ...

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Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles.

Authors: Sharifzadeh S, Shirley JD, Carlson EE Abstract ABPP methods have been utilized for the last two decades as a means to investigate complex proteomes in all three domains of life. Extensive use in eukaryotes has provided a more fundamental understanding of the biological processes involved in numerous diseases and has driven drug discovery and treatment campaigns. However, the use of ABPP in prokaryotes has been less common, although it has gained more attention over the last decade. The urgent need for understanding bacteriophysiology and bacterial pathogenicity at a foundational level has never been more apparent, as the rise in antibiotic resistance has resulted in the inadequate and ineffective treatment of infections. This is not only a result of resistance to clinicall...

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Correction to: Agrobacterium: A Genome-Editing Tool-Delivery System.

Authors: Sardesai N, Subramanyam S Abstract By mistake the chapter was published with incorrect author name. The chapter has now been corrected. PMID: 30232603 [PubMed - as supplied by publisher] (Source: Current Topics in Microbiology and Immunology)

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Severe allergic reaction during angioplasty culminating to fatal acute stent thrombosis: An association with Kounis syndrome

Kounis syndrome is a systemic complication following an allergic reaction, presenting with coronary artery spasm or thrombosis and occasionally with stent thrombosis that can have fatal outcome. (Source: Heart and Lung)

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Enteroaggregative Escherichia coli.

Authors: Jenkins C Abstract Enteroaggregative Escherichia coli (EAEC, formerly known as "EAggEC") cause acute or persistent watery diarrhoea (with or without mucus) in children, predominantly in low-income countries, and are associated with travellers' diarrhoea in children and adults in middle and high income countries. The diverse nature of EAEC is such that not all strains cause disease. Conversely, certain strains of EAEC possess additional virulence determinants associated with the ability to cause severe diarrhoea and other symptoms, which might be life-threatening in vulnerable patients. The EAEC virulence factors described to date are either encoded on the large virulence plasmid of EAEC (plasmid of aggregative adherence) or on pathogenicity islands on the chromosome. Testi...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OJ7ZzI

Human Organotypic Models for Anti-infective Research.

Authors: Hendriks A, Cruz AR, Soldaini E, Manetti AGO, Bagnoli F Abstract The use of human organotypic models for biomedical research is experiencing a significant increase due to their biological relevance, the possibility to perform high-throughput analyses, and their cost efficiency. In the field of anti-infective research, comprising the search for novel antipathogenic treatments including vaccines, efforts have been made to reduce the use of animal models. That is due to two main reasons: unreliability of data obtained with animal models and the increasing willingness to reduce the use of animals in research for ethical reasons. Human three-dimensional (3-D) models may substitute and/or complement in vivo studies, to increase the translational value of preclinical data. Here, ...

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Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles.

Authors: Sharifzadeh S, Shirley JD, Carlson EE Abstract ABPP methods have been utilized for the last two decades as a means to investigate complex proteomes in all three domains of life. Extensive use in eukaryotes has provided a more fundamental understanding of the biological processes involved in numerous diseases and has driven drug discovery and treatment campaigns. However, the use of ABPP in prokaryotes has been less common, although it has gained more attention over the last decade. The urgent need for understanding bacteriophysiology and bacterial pathogenicity at a foundational level has never been more apparent, as the rise in antibiotic resistance has resulted in the inadequate and ineffective treatment of infections. This is not only a result of resistance to clinicall...

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Correction to: Agrobacterium: A Genome-Editing Tool-Delivery System.

Authors: Sardesai N, Subramanyam S Abstract By mistake the chapter was published with incorrect author name. The chapter has now been corrected. PMID: 30232603 [PubMed - as supplied by publisher] (Source: Current Topics in Microbiology and Immunology)

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Severe allergic reaction during angioplasty culminating to fatal acute stent thrombosis: An association with Kounis syndrome

Kounis syndrome is a systemic complication following an allergic reaction, presenting with coronary artery spasm or thrombosis and occasionally with stent thrombosis that can have fatal outcome. (Source: Heart and Lung)

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Effects of Peer Support Interventions on the Communication of Preschoolers with Autism Spectrum Disorder: A Systematic Review

Semin Speech Lang DOI: 10.1055/s-0038-1670670Many young children with autism spectrum disorders (ASDs) experience difficulty in the development of communication skills. Teaching peers to make use of communication support behaviors has been investigated as a strategy to increase communication for young children with ASD in early childhood settings. The purpose of this systematic review was to examine (1) the overall effects of peer support interventions on the communication of young children with ASD and (2) any possible moderating variables related to participant and intervention characteristics. The social support model was used as a framework for the study of intervention components. Eighteen single-case experimental design studies (48 children with ASD) met the inclusion criteria and we...

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Navigating Through Cancer

Navigating Through Cancer  KELOLAND TVFull coverage

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New study raises hopes for vaccine to treat head and neck cancer

New study raises hopes for vaccine to treat head and neck cancer  Finger Lakes TimesDNA vaccine leads to immune responses in HPV-related head and neck cancer  EurekAlert (press release)Full coverage

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Navigating Through Cancer

Navigating Through Cancer  KELOLAND TVFull coverage

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New study raises hopes for vaccine to treat head and neck cancer

New study raises hopes for vaccine to treat head and neck cancer  Finger Lakes TimesDNA vaccine leads to immune responses in HPV-related head and neck cancer  EurekAlert (press release)Full coverage

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The Burden of Sinusitis in Hematologic Transplant Patients: A National Perspective

The Laryngoscope, EarlyView. (Source: The Laryngoscope)

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The Burden of Sinusitis in Hematologic Transplant Patients: A National Perspective

The Laryngoscope, EarlyView. (Source: The Laryngoscope)

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Oxidative damage and DNA damage in lungs of an ovalbumin-induced asthmatic murine model.

Conclusions: Our study showed that oxidative damage and DNA damage existed in the airway of asthmatic mice. NU7441 augmented DNA damage level, and moreover, it also attenuated infiltration of inflammatory cells and pro-inflammatory cytokine levels in asthmatic lungs. PMID: 30233855 [PubMed] (Source: Journal of Thoracic Disease)

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Oxidative damage and DNA damage in lungs of an ovalbumin-induced asthmatic murine model.

Conclusions: Our study showed that oxidative damage and DNA damage existed in the airway of asthmatic mice. NU7441 augmented DNA damage level, and moreover, it also attenuated infiltration of inflammatory cells and pro-inflammatory cytokine levels in asthmatic lungs. PMID: 30233855 [PubMed] (Source: Journal of Thoracic Disease)

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Your Cancer Highlight: Galectin Surprises With Early-Stage Collaborative Data

Your Cancer Highlight: Galectin Surprises With Early-Stage Collaborative Data  Seeking AlphaGalectin's GR-MD-02 Positive in Phase Ib Study With Keytruda  NasdaqFull coverage

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New study raises hopes for vaccine to treat head and neck cancer

New study raises hopes for vaccine to treat head and neck cancer  Herald-Mail MediaDNA vaccine leads to immune responses in HPV-related head and neck cancer  EurekAlert (press release)Full coverage

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Introduction

It is truly an honor to be invited to be the guest editor of an issue of Operative Techniques in Otolaryngology Head and Neck Surgery. What's more, the issue focusses on one of my favorite subjects: salivary gland pathology and surgery. When considering parotid tumors alone, the incidence is approximately 4/100,000 in the United States. The current census of the United States is 324 million and approximately 25% of whom are children1. If one assumes that 243 million Americans over the age 18 are at risk for developing these tumors, then approximately 10,000 parotid tumors will occur and potentially present each year.

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A Corpus-Based Exploration of the Discourse Marker Well in Spoken Interlanguage.

Authors: Huang LF Abstract This corpus-based study examines the widely-used discourse marker well in Chinese-speaking learners' speech and compares its frequencies in native speaker data and Swedish learners. While Swedish learners overuse well, Chinese-speaking learners (predominantly at the upper-intermediate level) significantly underuse it. The positions and functions of well are further examined using a functional framework. One-fourth of the Chinese-speaking learners who use well manipulate its positions in utterances in a similar way to native speakers. In terms of functions, well is employed for speech management much more frequently than for attitudinal purposes. The greater use of the former does not generally create negative effects, but the under-representation of the l...

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Vocabulary as a Central Link between Phonological Working Memory and Narrative Competence: Evidence from Monolingual and Bilingual Four-Year-Olds from Different Socioeconomic Backgrounds.

Authors: Korecky-Kröll K, Dobek N, Blaschitz V, Sommer-Lolei S, Boniecki M, Uzunkaya-Sharma K, Dressler WU Abstract Phonological working memory capacity, vocabulary size, and narrative competence are important skills in children's L1 and L2 acquisition, which may vary as a function of their language background and socioeconomic status (SES). We investigated test data of 56 typically developing 4-year-old kindergarten children from two SES and two language backgrounds: 29 children (15 higher SES, 14 lower SES) were monolingual German-speaking, and 27 children (14 higher SES, 13 lower SES) were successive Turkish-German bilinguals. The tests comprised a non-word repetition task testing phonological working memory, receptive vocabulary tests (in L1 and L2), and a narrative task. We i...

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Biomarkers in Chronic Rhinosinusitis with Nasal Polyps

Chronic rhinosinusitis is a complex disease that exists along the inflammatory spectrum between types 1 and 2 inflammation. The classic phenotypic differentiation of chronic rhinosinusitis based on the presence or absence of inflammatory polyps remains one of the best differentiators of response to therapy. Development of biologics for the treatment of atopic disease and asthma and topical therapies for sinusitis have placed renewed emphasis on understanding the pathophysiology of polyp disease. Identification of key markers of polyposis will allow for better stratification of inflammatory polyp disease endotypes to objectively identify medical therapies and track response to treatment. (Source: Immunology and Allergy Clinics of North America)

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Airway Eosinophilopoietic and Autoimmune Mechanisms of Eosinophilia in Severe Asthma

Eosinophils are critical in asthma biology, contributing to symptoms, airflow obstruction, airway hyperresponsiveness, and remodeling. In severe asthma, in addition to local maturation in bone marrow, in situ eosinophilopoiesis plays a key role in the persistence of airway eosinophilia. Local milieu of structural, epithelial and inflammatory cells contribute by generating eosinophilopoietic cytokines in response to epithelial-derived alarmins. Another mechanism of persistent airway eosinophilia is glucocorticosteroid insensitivity, which is linked to recurrent airway infections and presence of local autoantibodies. Novel molecules are being developed to target specific immune pathways as potential steroid-sparing strategies. (Source: Immunology and Allergy Clinics of North America)

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Exhaled Nitric Oxide

Fractional concentration of exhaled nitric oxide (FENO) is a biomarker used to identify allergic airway inflammation. Because it is noninvasive and easy to obtain, its utility has been studied in the diagnosis and management of several respiratory diseases. Much of the research has been done in asthma, and many studies support the use of FENO in aiding diagnosing asthma, predicting steroid responsiveness, and preventing exacerbations by guiding medication dosage and assessing adherence. (Source: Immunology and Allergy Clinics of North America)

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Molecular Endotypes Contribute to the Heterogeneity of Asthma

Diagnosis and management of asthma is commonly implemented based on clinical assessment. Although these nonmolecular biomarkers have been useful, limited resolution of the heterogeneity among asthmatic patients and little information regarding the underlying pathobiology of disease in individuals have been provided. Molecular endotying using global transcriptome expression profiling associated with clinical features of asthma has improved our understanding of disease mechanisms, risk assessment of asthma exacerbations, and treatment responses, especially in patients with type 2 inflammation. Further advances in establishing pathobiological subgroups, bioactive pathways, and true disease endotypes hold potential for a more personalized medical approach in asthmatic patients. (Source: Immuno...

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Your Cancer Highlight: Galectin Surprises With Early-Stage Collaborative Data

Your Cancer Highlight: Galectin Surprises With Early-Stage Collaborative Data  Seeking AlphaGalectin's GR-MD-02 Positive in Phase Ib Study With Keytruda  NasdaqFull coverage

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New study raises hopes for vaccine to treat head and neck cancer

New study raises hopes for vaccine to treat head and neck cancer  Herald-Mail MediaDNA vaccine leads to immune responses in HPV-related head and neck cancer  EurekAlert (press release)Full coverage

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Introduction

It is truly an honor to be invited to be the guest editor of an issue of Operative Techniques in Otolaryngology Head and Neck Surgery. What's more, the issue focusses on one of my favorite subjects: salivary gland pathology and surgery. When considering parotid tumors alone, the incidence is approximately 4/100,000 in the United States. The current census of the United States is 324 million and approximately 25% of whom are children1. If one assumes that 243 million Americans over the age 18 are at risk for developing these tumors, then approximately 10,000 parotid tumors will occur and potentially present each year.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QQT8EX

A Corpus-Based Exploration of the Discourse Marker Well in Spoken Interlanguage.

Authors: Huang LF Abstract This corpus-based study examines the widely-used discourse marker well in Chinese-speaking learners' speech and compares its frequencies in native speaker data and Swedish learners. While Swedish learners overuse well, Chinese-speaking learners (predominantly at the upper-intermediate level) significantly underuse it. The positions and functions of well are further examined using a functional framework. One-fourth of the Chinese-speaking learners who use well manipulate its positions in utterances in a similar way to native speakers. In terms of functions, well is employed for speech management much more frequently than for attitudinal purposes. The greater use of the former does not generally create negative effects, but the under-representation of the l...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PVD97b

Vocabulary as a Central Link between Phonological Working Memory and Narrative Competence: Evidence from Monolingual and Bilingual Four-Year-Olds from Different Socioeconomic Backgrounds.

Authors: Korecky-Kröll K, Dobek N, Blaschitz V, Sommer-Lolei S, Boniecki M, Uzunkaya-Sharma K, Dressler WU Abstract Phonological working memory capacity, vocabulary size, and narrative competence are important skills in children's L1 and L2 acquisition, which may vary as a function of their language background and socioeconomic status (SES). We investigated test data of 56 typically developing 4-year-old kindergarten children from two SES and two language backgrounds: 29 children (15 higher SES, 14 lower SES) were monolingual German-speaking, and 27 children (14 higher SES, 13 lower SES) were successive Turkish-German bilinguals. The tests comprised a non-word repetition task testing phonological working memory, receptive vocabulary tests (in L1 and L2), and a narrative task. We i...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QLWd90

Biomarkers in Chronic Rhinosinusitis with Nasal Polyps

Chronic rhinosinusitis is a complex disease that exists along the inflammatory spectrum between types 1 and 2 inflammation. The classic phenotypic differentiation of chronic rhinosinusitis based on the presence or absence of inflammatory polyps remains one of the best differentiators of response to therapy. Development of biologics for the treatment of atopic disease and asthma and topical therapies for sinusitis have placed renewed emphasis on understanding the pathophysiology of polyp disease. Identification of key markers of polyposis will allow for better stratification of inflammatory polyp disease endotypes to objectively identify medical therapies and track response to treatment. (Source: Immunology and Allergy Clinics of North America)

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Exhaled Breath Condensate

Exhaled breath condensate (EBC) is a promising source of biomarkers of lung disease. EBC research and utility has increased substantially over the past 2 decades. This review summarizes many of the factors regarding the composition of EBC, its collection, and analysis for the utility of both clinicians and researchers. (Source: Immunology and Allergy Clinics of North America)

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Urinary Leukotriene E4 as a Biomarker of Exposure, Susceptibility, and Risk in Asthma

Measurement of urinary leukotriene E4 (uLTE4) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene (CysLT) production and changes in CysLT production. Recent studies have reported on novel LTE4 receptor interactions and genetic polymorphisms causing CysLT variability. The applications of uLTE4 as a biomarker continue to expand, including evaluation of environmental exposures, asthma severity risk, aspirin sensitivity, predicting atopy in preschool age children, obstructive sleep apnea, and predicting susceptibility to leukotriene receptor antagonists. (Source: Immunology and Allergy Clinics of North America)

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Airway Eosinophilopoietic and Autoimmune Mechanisms of Eosinophilia in Severe Asthma

Eosinophils are critical in asthma biology, contributing to symptoms, airflow obstruction, airway hyperresponsiveness, and remodeling. In severe asthma, in addition to local maturation in bone marrow, in situ eosinophilopoiesis plays a key role in the persistence of airway eosinophilia. Local milieu of structural, epithelial and inflammatory cells contribute by generating eosinophilopoietic cytokines in response to epithelial-derived alarmins. Another mechanism of persistent airway eosinophilia is glucocorticosteroid insensitivity, which is linked to recurrent airway infections and presence of local autoantibodies. Novel molecules are being developed to target specific immune pathways as potential steroid-sparing strategies. (Source: Immunology and Allergy Clinics of North America)

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Exhaled Nitric Oxide

Fractional concentration of exhaled nitric oxide (FENO) is a biomarker used to identify allergic airway inflammation. Because it is noninvasive and easy to obtain, its utility has been studied in the diagnosis and management of several respiratory diseases. Much of the research has been done in asthma, and many studies support the use of FENO in aiding diagnosing asthma, predicting steroid responsiveness, and preventing exacerbations by guiding medication dosage and assessing adherence. (Source: Immunology and Allergy Clinics of North America)

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Molecular Endotypes Contribute to the Heterogeneity of Asthma

Diagnosis and management of asthma is commonly implemented based on clinical assessment. Although these nonmolecular biomarkers have been useful, limited resolution of the heterogeneity among asthmatic patients and little information regarding the underlying pathobiology of disease in individuals have been provided. Molecular endotying using global transcriptome expression profiling associated with clinical features of asthma has improved our understanding of disease mechanisms, risk assessment of asthma exacerbations, and treatment responses, especially in patients with type 2 inflammation. Further advances in establishing pathobiological subgroups, bioactive pathways, and true disease endotypes hold potential for a more personalized medical approach in asthmatic patients. (Source: Immuno...

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Higher Flu-Vaccination Rates Seen After EHR Nudge Higher Flu-Vaccination Rates Seen After EHR Nudge

Reuters Health Information (Source: Medscape Allergy Headlines)

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After Florence, Significant Worry Over Infectious Diseases After Florence, Significant Worry Over Infectious Diseases

Medscape Medical News (Source: Medscape Allergy Headlines)

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Lipid A Remodeling Is a Pathoadaptive Mechanism That Impacts Lipopolysaccharide Recognition and Intracellular Survival of Burkholderia pseudomallei [Cellular Microbiology: Pathogen-Host Cell Molecular Interactions]

Burkholderia pseudomallei causes the severe disease melioidosis. The bacterium subverts the host immune system and replicates inside cells, and host mortality results primarily from sepsis-related complications. Lipopolysaccharide (LPS) is a major virulence factor and mediator of sepsis that many pathogens capable of intracellular growth modify to reduce their immunological "footprint." The binding strength of B. pseudomallei LPS for human LPS binding protein (hLBP) was measured using surface plasmon resonance. The structures of lipid A isolated from B. pseudomallei under different temperatures were analyzed by matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS), and the gene expression of two lipid A remodeling genes, lpxO and pagL, was invest...

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Higher Flu-Vaccination Rates Seen After EHR Nudge Higher Flu-Vaccination Rates Seen After EHR Nudge

Reuters Health Information (Source: Medscape Allergy Headlines)

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After Florence, Significant Worry Over Infectious Diseases After Florence, Significant Worry Over Infectious Diseases

Medscape Medical News (Source: Medscape Allergy Headlines)

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Lipid A Remodeling Is a Pathoadaptive Mechanism That Impacts Lipopolysaccharide Recognition and Intracellular Survival of Burkholderia pseudomallei [Cellular Microbiology: Pathogen-Host Cell Molecular Interactions]

Burkholderia pseudomallei causes the severe disease melioidosis. The bacterium subverts the host immune system and replicates inside cells, and host mortality results primarily from sepsis-related complications. Lipopolysaccharide (LPS) is a major virulence factor and mediator of sepsis that many pathogens capable of intracellular growth modify to reduce their immunological "footprint." The binding strength of B. pseudomallei LPS for human LPS binding protein (hLBP) was measured using surface plasmon resonance. The structures of lipid A isolated from B. pseudomallei under different temperatures were analyzed by matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS), and the gene expression of two lipid A remodeling genes, lpxO and pagL, was invest...

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Risk factors for cervical lymph node metastasis in endoscopically resected superficial hypopharyngeal cancers

Hypopharyngeal cancer is a head and neck cancer with a poor prognosis, and most cases show metastases on diagnosis. Cervical lymph node (LN) metastasis is a poor prognostic factor in hypopharyngeal cancer patients. The identification of risk factors for LN metastasis can help guide surgical treatment strategies for these patients.

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Risk factors for cervical lymph node metastasis in endoscopically resected superficial hypopharyngeal cancers

Hypopharyngeal cancer is a head and neck cancer with a poor prognosis, and most cases show metastases on diagnosis. Cervical lymph node (LN) metastasis is a poor prognostic factor in hypopharyngeal cancer patients. The identification of risk factors for LN metastasis can help guide surgical treatment strategies for these patients.

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One-Hour Procedure Relieves Years of Sinus Problems

Treatment TermsEar nose and throatSinus and nasal conditions Overview Frequent, severe sinus infections made Emily Drews miserable for years, especially when pollen triggered her allergies. Then she had a sinuplasty procedure at Duke, and the results were dramatic. Drews now breathes easily, no matter the season. Hero Image2018_emily_sinuplasty_1932x862.jpg Preview Image Content Blocks CTA Header Learn More About CTA ButtonSinus Infections and Nasal Disorders Patient Name Emily Drews Patient Photo Gender Female Patient Story Quote I had such great results. I 've been able to blow my nose and clear it ever since the procedure. Featured Doctors David W. Jang, MD BodyDisplay in Announcement Section:  ArchivedThumbnail Image: Pin to Top of WiFi Page:  (Sourc...

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Higher Flu-Vaccination Rates Seen After EHR Nudge Higher Flu-Vaccination Rates Seen After EHR Nudge

Reuters Health Information (Source: Medscape Allergy Headlines)

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One-Hour Procedure Relieves Years of Sinus Problems

Treatment TermsEar nose and throatSinus and nasal conditions Overview Frequent, severe sinus infections made Emily Drews miserable for years, especially when pollen triggered her allergies. Then she had a sinuplasty procedure at Duke, and the results were dramatic. Drews now breathes easily, no matter the season. Hero Image2018_emily_sinuplasty_1932x862.jpg Preview Image Content Blocks CTA Header Learn More About CTA ButtonSinus Infections and Nasal Disorders Patient Name Emily Drews Patient Photo Gender Female Patient Story Quote I had such great results. I 've been able to blow my nose and clear it ever since the procedure. Featured Doctors David W. Jang, MD BodyDisplay in Announcement Section:  ArchivedThumbnail Image: Pin to Top of WiFi Page:  (Sourc...

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Loss-of-function mutations in CARD14 are associated with a severe variant of atopic dermatitis

Dominant gain-of-function mutations in CARD14, encoding a known regulator of NF-κB, cause psoriasis and related disorders. Here, the authors show that dominant negative mutations in the same gene result in severe atopic dermatitis and decreased NF-κB signaling.

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Loss-of-function mutations in CARD14 are associated with a severe variant of atopic dermatitis

Dominant gain-of-function mutations in CARD14, encoding a known regulator of NF-κB, cause psoriasis and related disorders. Here, the authors show that dominant negative mutations in the same gene result in severe atopic dermatitis and decreased NF-κB signaling.

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Your Cancer Highlight: Galectin Surprises With Early-Stage Collaborative Data

Your Cancer Highlight: Galectin Surprises With Early-Stage Collaborative Data  Seeking AlphaFull coverage

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Recycling Full Thickness Skin Graft from Failing Free Flaps in Salvage Procedures

Free flap loss is a dreaded complication in microsurgery. When a second free flap is harvested, the enlarged donor site may not be amenable to primary closure, and a split thickness skin graft (STSG) is necessary. If we salvage the skin portion of the failing flap for subsequent wound closure, we not only minimize additional donor sites, we also reap the many functional and cosmetic advantages of full thickness skin grafts (FTSG) over STSG. The recyclability of salvaged skin is mainly dependent on the warm ischemia time.

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Recycling Full Thickness Skin Graft from Failing Free Flaps in Salvage Procedures

Free flap loss is a dreaded complication in microsurgery. When a second free flap is harvested, the enlarged donor site may not be amenable to primary closure, and a split thickness skin graft (STSG) is necessary. If we salvage the skin portion of the failing flap for subsequent wound closure, we not only minimize additional donor sites, we also reap the many functional and cosmetic advantages of full thickness skin grafts (FTSG) over STSG. The recyclability of salvaged skin is mainly dependent on the warm ischemia time.

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Your Cancer Highlight: Galectin Surprises With Early-Stage Collaborative Data

Your Cancer Highlight: Galectin Surprises With Early-Stage Collaborative Data  Seeking AlphaFull coverage

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A Statistical View of the World Head and Neck Cancer Market With Tables and Figures | Datasheets 2018-2023

A Statistical View of the World Head and Neck Cancer Market With Tables and Figures | Datasheets 2018-2023  News Australia TodayFull coverage

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A Statistical View of the World Head and Neck Cancer Market With Tables and Figures | Datasheets 2018-2023

A Statistical View of the World Head and Neck Cancer Market With Tables and Figures | Datasheets 2018-2023  News Australia TodayFull coverage

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The housing first technical assistance and training (HFTAT) implementation strategy: outcomes from a mixed methods study of three programs

This paper discusses the initial testing of the Housing First Training and Technical Assistance (HFTAT) Program, a multifaceted, distance-based strategy for the implementation of the Housing First (HF) support...

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The housing first technical assistance and training (HFTAT) implementation strategy: outcomes from a mixed methods study of three programs

This paper discusses the initial testing of the Housing First Training and Technical Assistance (HFTAT) Program, a multifaceted, distance-based strategy for the implementation of the Housing First (HF) support...

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Anesthesia Safety in Otolaryngology

This article highlights the important relationship between the otolaryngologist and anesthesiologist, focusing on intraoperative patient safety for otolaryngologic surgery. In addition, consideration of preoperative history, physical examination, and potential postoperative complications helps guide the otolaryngologist and anesthesiologist in formulating an appropriate and collaborative management strategy.

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Anesthesia Safety in Otolaryngology

This article highlights the important relationship between the otolaryngologist and anesthesiologist, focusing on intraoperative patient safety for otolaryngologic surgery. In addition, consideration of preoperative history, physical examination, and potential postoperative complications helps guide the otolaryngologist and anesthesiologist in formulating an appropriate and collaborative management strategy.

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Simulation Saves the Day (and Patient)

Surgeons can use simulation to improve the safety of the systems they work within, around, because of, and despite. Health care is a complex adaptive system that can never be completely knowable; simulation can expose aspects of patient care delivery that are not necessarily evident prospectively, during planning, or retrospectively, during investigations or audits. The constraints of patient care processes and adaptive capacity of health care providers may become most evident during simulations conducted "in situ" using real teams and real equipment, in actual patient care locations.

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Simulation Saves the Day (and Patient)

Surgeons can use simulation to improve the safety of the systems they work within, around, because of, and despite. Health care is a complex adaptive system that can never be completely knowable; simulation can expose aspects of patient care delivery that are not necessarily evident prospectively, during planning, or retrospectively, during investigations or audits. The constraints of patient care processes and adaptive capacity of health care providers may become most evident during simulations conducted "in situ" using real teams and real equipment, in actual patient care locations.

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Patient Safety and Quality for Office-Based Procedures in Otolaryngology

Office-based procedures have increased in frequency with the recent changes in the current health care climate prioritizing improved efficiency and greater value in the care that is delivered. This article focuses on patient safety and quality issues that are specific to procedures in the office setting of an Otolaryngologist. Specific topics are categorized into preprocedure planning, procedural execution, and postprocedure follow-up. Several best practice recommendations are included to promote and simplify the integration of these quality and safety measures into every office setting.

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Patient Safety and Quality for Office-Based Procedures in Otolaryngology

Office-based procedures have increased in frequency with the recent changes in the current health care climate prioritizing improved efficiency and greater value in the care that is delivered. This article focuses on patient safety and quality issues that are specific to procedures in the office setting of an Otolaryngologist. Specific topics are categorized into preprocedure planning, procedural execution, and postprocedure follow-up. Several best practice recommendations are included to promote and simplify the integration of these quality and safety measures into every office setting.

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Higher Flu-Vaccination Rates Seen After EHR Nudge Higher Flu-Vaccination Rates Seen After EHR Nudge

Reuters Health Information (Source: Medscape Allergy Headlines)

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ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data

Aaron M. Rosenfeld, Wenzhao Meng, Eline T. Luning Prak, Uri Hershberg (Source: Frontiers in Immunology)

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Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

Jos é A. Crippa, Francisco S. Guimarães, Alline C. Campos, Antonio W. Zuardi (Source: Frontiers in Immunology)

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Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing

Publication date: Available online 20 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Maria J. Torres, N. Franklin Adkinson, Jean-Christoph Caubet, David A. Khan, Mona I. Kidon, Louis Mendelson, Eva Rebelo Gomes, Ticha Rerkpattanapipat, Shuchen Zhang, Eric Macy, AAAAI/WAO 2018 Symposium Penicillin and Cephalosporin Allergy Testing Working GroupAll beta-lactam use is associated with a certain rate of adverse reactions. Many of these adverse reactions result in an allergy to the beta-lactam being entered into the patient's medical record. Unfortunately, only a small minority of these recorded allergies are clinically significant immunologically mediated drug hypersensitivity. An unconfirmed allergy to beta-lactams is a significant public health ris...

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Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center

CONCLUSIONOur data suggests that our FPIES OFC protocol is safe. Early administration of IVF may prevent the development of hypotension. It is difficult to stratify risk of severe or delayed reaction based on patient characteristics and more data is needed to identify those appropriate for home introduction. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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Omentin-1 protects against bleomycin-induced acute lung injury

Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Yan Zhou, CaiXia Hao, Chen Li, XiaoTing Huang, XiaoHong Li, YiTing Tang, YanHong Huang, SiYuan Tang, Wei Liu, DanDan Feng, JianPing Xu, ShaoJie Yue, Hui Xie, ZiQiang LuoAbstractAcute lung injury (ALI) is characterized by inflammatory cell infiltration, macrophage activation, and excessive pro-inflammatory cytokine production. Bleomycin (BLM) is widely used to induce acute lung injury (ALI) and fibrosis in murine models. Intratracheally administration of BLM leads to the early stage of inflammatory response and the late stage of collagen deposition. Omentin-1 exerts an anti-inflammatory role in reducing tumor necrosis factor α (TNF-α)-induced cyclooxygenase-2 expression in endothelial cells and attenuating l...

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Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis.

CONCLUSION: The majority of patients (64.8%) who underwent lumbar puncture had cerebrospinal fluid findings suggestive of neurosyphilis. Elevated CSF lymphocyte cell count and total protein count are highly suggestive of neurosyphilis. PMID: 30230943 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Effectiveness of Intraductal Meibomian Gland Probing in Addition to the Conventional Treatment in Patients with Obstructive Meibomian Gland Dysfunction.

CONCLUSION: This study showed that intraductal meibomian gland probing seems to provide rapid symptom relief and clinical improvement for patients with O-MGD. PMID: 30235042 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Uveitis of Unknown Etiology: Clinical and Outcome features. A Retrospective Analysis of 355 Patients.

CONCLUSION: A prolonged follow-up, with repeated exams, may allow the determination of an etiology in about one-fifth of uveitis initially considered as idiopathic. PMID: 30234412 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Innate Immunity Biomarkers for Early Detection of Keratoconus.

CONCLUSIONS: TLR2 and TLR4 expression in corneal and conjunctival epithelial cells may constitute predictive biomarkers for the early detection of KC. PMID: 30230940 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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E. coli Nissle 1917 is a safe mucosal delivery vector for a birch-grass pollen chimera to prevent allergic poly-sensitization

<i>E. coli</i> Nissle 1917 is a safe mucosal delivery vector for a birch-grass pollen chimera to prevent allergic poly-sensitization, Published online: 21 September 2018; doi:10.1038/s41385-018-0084-6E. coli Nissle 1917 is a safe mucosal delivery vector for a birch-grass pollen chimera to prevent allergic poly-sensitization (Source: Mucosal Immunology)

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Cellular Interactions in the Intestinal Stem Cell Niche

AbstractEpithelial cells are one of the most actively cycling cells in a mammalian organism and therefore are prone to malignant transformation. Already during organogenesis, the connective tissue (mesenchyme) provides instructive signals for the epithelium. In an adult organism, the mesenchyme is believed to provide crucial regulatory signals for the maintenance and regeneration of epithelial cells. Here, we discuss the role of intestinal myofibroblasts, α-smooth muscle actin-positive stromal (mesenchymal) cells, as an important regulatory part of the intestinal stem cell niche. Better understanding of the cross-talk between myofibroblasts and the epithelium in the intestine has implications for advances in regenerative medicine, and improved thera peutic strategies for inflammatory bowe...

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ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data

Aaron M. Rosenfeld, Wenzhao Meng, Eline T. Luning Prak, Uri Hershberg (Source: Frontiers in Immunology)

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Positive & Negative Roles of Innate Effector Cells in Controlling Cancer Progression

Dorian Stolk, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk, Mark A. Exley (Source: Frontiers in Immunology)

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Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

Jos é A. Crippa, Francisco S. Guimarães, Alline C. Campos, Antonio W. Zuardi (Source: Frontiers in Immunology)

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Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing

Publication date: Available online 20 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Maria J. Torres, N. Franklin Adkinson, Jean-Christoph Caubet, David A. Khan, Mona I. Kidon, Louis Mendelson, Eva Rebelo Gomes, Ticha Rerkpattanapipat, Shuchen Zhang, Eric Macy, AAAAI/WAO 2018 Symposium Penicillin and Cephalosporin Allergy Testing Working GroupAll beta-lactam use is associated with a certain rate of adverse reactions. Many of these adverse reactions result in an allergy to the beta-lactam being entered into the patient's medical record. Unfortunately, only a small minority of these recorded allergies are clinically significant immunologically mediated drug hypersensitivity. An unconfirmed allergy to beta-lactams is a significant public health ris...

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Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center

CONCLUSIONOur data suggests that our FPIES OFC protocol is safe. Early administration of IVF may prevent the development of hypotension. It is difficult to stratify risk of severe or delayed reaction based on patient characteristics and more data is needed to identify those appropriate for home introduction. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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Omentin-1 protects against bleomycin-induced acute lung injury

Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Yan Zhou, CaiXia Hao, Chen Li, XiaoTing Huang, XiaoHong Li, YiTing Tang, YanHong Huang, SiYuan Tang, Wei Liu, DanDan Feng, JianPing Xu, ShaoJie Yue, Hui Xie, ZiQiang LuoAbstractAcute lung injury (ALI) is characterized by inflammatory cell infiltration, macrophage activation, and excessive pro-inflammatory cytokine production. Bleomycin (BLM) is widely used to induce acute lung injury (ALI) and fibrosis in murine models. Intratracheally administration of BLM leads to the early stage of inflammatory response and the late stage of collagen deposition. Omentin-1 exerts an anti-inflammatory role in reducing tumor necrosis factor α (TNF-α)-induced cyclooxygenase-2 expression in endothelial cells and attenuating l...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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Atypical Perinuclear Anti-Neutrophil Cytoplasmic Antibodies in Ocular Inflammatory Diseases.

CONCLUSION: In contrast to typical C-ANCA and P-ANCA, atypical P-ANCA seropositivity was not associated with severe vasculitis or poor prognosis in patients with the OID. PMID: 30230931 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis.

CONCLUSION: The majority of patients (64.8%) who underwent lumbar puncture had cerebrospinal fluid findings suggestive of neurosyphilis. Elevated CSF lymphocyte cell count and total protein count are highly suggestive of neurosyphilis. PMID: 30230943 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xFhWH2

Effectiveness of Intraductal Meibomian Gland Probing in Addition to the Conventional Treatment in Patients with Obstructive Meibomian Gland Dysfunction.

CONCLUSION: This study showed that intraductal meibomian gland probing seems to provide rapid symptom relief and clinical improvement for patients with O-MGD. PMID: 30235042 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QKkvAi

Uveitis of Unknown Etiology: Clinical and Outcome features. A Retrospective Analysis of 355 Patients.

CONCLUSION: A prolonged follow-up, with repeated exams, may allow the determination of an etiology in about one-fifth of uveitis initially considered as idiopathic. PMID: 30234412 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Endogenous Endophthalmitis Caused by Carbapenem-Resistant Hypervirulent Klebsiella Pneumoniae: A Case Report and Literature Review.

CONCLUSIONS: Endogenous endophthalmitis caused by CR-hvKP has emerged, which is a treatment challenge for both ophthalmologists and physicians. PMID: 30230939 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QPajXi

Innate Immunity Biomarkers for Early Detection of Keratoconus.

CONCLUSIONS: TLR2 and TLR4 expression in corneal and conjunctival epithelial cells may constitute predictive biomarkers for the early detection of KC. PMID: 30230940 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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E. coli Nissle 1917 is a safe mucosal delivery vector for a birch-grass pollen chimera to prevent allergic poly-sensitization

<i>E. coli</i> Nissle 1917 is a safe mucosal delivery vector for a birch-grass pollen chimera to prevent allergic poly-sensitization, Published online: 21 September 2018; doi:10.1038/s41385-018-0084-6E. coli Nissle 1917 is a safe mucosal delivery vector for a birch-grass pollen chimera to prevent allergic poly-sensitization (Source: Mucosal Immunology)

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Cellular Interactions in the Intestinal Stem Cell Niche

AbstractEpithelial cells are one of the most actively cycling cells in a mammalian organism and therefore are prone to malignant transformation. Already during organogenesis, the connective tissue (mesenchyme) provides instructive signals for the epithelium. In an adult organism, the mesenchyme is believed to provide crucial regulatory signals for the maintenance and regeneration of epithelial cells. Here, we discuss the role of intestinal myofibroblasts, α-smooth muscle actin-positive stromal (mesenchymal) cells, as an important regulatory part of the intestinal stem cell niche. Better understanding of the cross-talk between myofibroblasts and the epithelium in the intestine has implications for advances in regenerative medicine, and improved thera peutic strategies for inflammatory bowe...

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Local university researchers win $1.8M award to battle viral respiratory infections

A team of researchers at a local university could be making strides in viral respiratory infections research, thanks to new funding. Biology researchers at Wright State University will be receiving approximately $1.8 million over the next five years to fund their viral respiratory infections-focused project. The award was given by the National Institute of Allergy and Infectious Diseases, which is part of the National Institute s of Health. The team of researchers — led by biology professor Kate… (Source: bizjournals.com Health Care:Biotechnology headlines)

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Local university researchers win $1.8M award to battle viral respiratory infections

A team of researchers at a local university could be making strides in viral respiratory infections research, thanks to new funding. Biology researchers at Wright State University will be receiving approximately $1.8 million over the next five years to fund their viral respiratory infections-focused project. The award was given by the National Institute of Allergy and Infectious Diseases, which is part of the National Institute s of Health. The team of researchers — led by biology professor Kate… (Source: bizjournals.com Health Care:Biotechnology headlines)

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Purus Labs Issues Allergy Alert on Undeclared Milk and Soy in MyoWhey

Purus Labs, Inc of Plano, Texas is recalling MyoWhey Chocolate Cookie Crunch, because it may contain undeclared milk and soy. This only effects products with Lot number PL: 0100518 Exp: 04/2020. People who have an allergy or severe sensitivity to milk and soy run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

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Purus Labs Issues Allergy Alert on Undeclared Milk and Soy in MyoWhey

Purus Labs, Inc of Plano, Texas is recalling MyoWhey Chocolate Cookie Crunch, because it may contain undeclared milk and soy. This only effects products with Lot number PL: 0100518 Exp: 04/2020. People who have an allergy or severe sensitivity to milk and soy run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)

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New study raises hopes for vaccine to treat head and neck cancer

New study raises hopes for vaccine to treat head and neck cancer  Herald-Mail MediaDNA vaccine leads to immune responses in HPV-related head and neck cancer  Medical XpressHope for HPV-related cancers: New vaccine gives a boost to treating even the most advanced head and neck cancers  Daily MailFull coverage

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Head and Neck Cancer Therapeutics Market Clinical Reviews, Research Reports 2018

Head and Neck Cancer Therapeutics Market Clinical Reviews, Research Reports 2018  IDA ReportHead and Neck Cancer Treatment Market 2017 Growth Forecast Analysis by Manufacturers, Historic Growth, Trends ...  Industry Research NewsFull coverage

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Head and Neck Cancer Therapeutics Market Clinical Reviews, Research Reports 2018

Head and Neck Cancer Therapeutics Market Clinical Reviews, Research Reports 2018  IDA ReportHead and Neck Cancer Treatment Market 2017 Growth Forecast Analysis by Manufacturers, Historic Growth, Trends ...  Industry Research NewsFull coverage

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Scientists map interactions between head and neck cancer and HPV virus

Scientists map interactions between head and neck cancer and HPV virus  Science DailyScientists Plot Communication Between Head And Neck Cancer And HPV Virus  FMR Blog (blog)Full coverage

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Scientists map interactions between head and neck cancer and HPV virus

Scientists map interactions between head and neck cancer and HPV virus  Science DailyScientists Plot Communication Between Head And Neck Cancer And HPV Virus  FMR Blog (blog)Full coverage

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Evolutionary Pressure against MHC Class II Binding Cancer Mutations

Publication date: Available online 20 September 2018Source: CellAuthor(s): Rachel Marty, Wesley Kurt Thompson, Rany M. Salem, Maurizio Zanetti, Hannah CarterSummaryThe anti-cancer immune response against mutated peptides of potential immunological relevance (neoantigens) is primarily attributed to MHC-I-restricted cytotoxic CD8+ T cell responses. MHC-II-restricted CD4+ T cells also drive anti-tumor responses, but their relation to neoantigen selection and tumor evolution has not been systematically studied. Modeling the potential of an individual's MHC-II genotype to present 1,018 driver mutations in 5,942 tumors, we demonstrate that the MHC-II genotype constrains the mutational landscape during tumorigenesis in a manner complementary to MHC-I. Mutations poorly bound to MHC-II are posi...

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Evolutionary Pressure against MHC Class II Binding Cancer Mutations

Publication date: Available online 20 September 2018Source: CellAuthor(s): Rachel Marty, Wesley Kurt Thompson, Rany M. Salem, Maurizio Zanetti, Hannah CarterSummaryThe anti-cancer immune response against mutated peptides of potential immunological relevance (neoantigens) is primarily attributed to MHC-I-restricted cytotoxic CD8+ T cell responses. MHC-II-restricted CD4+ T cells also drive anti-tumor responses, but their relation to neoantigen selection and tumor evolution has not been systematically studied. Modeling the potential of an individual's MHC-II genotype to present 1,018 driver mutations in 5,942 tumors, we demonstrate that the MHC-II genotype constrains the mutational landscape during tumorigenesis in a manner complementary to MHC-I. Mutations poorly bound to MHC-II are posi...

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Local university researchers win $1.8M award to battle viral respiratory infections

A team of researchers at a local university could be making strides in viral respiratory infections research, thanks to new funding. Biology researchers at Wright State University will be receiving approximately $1.8 million over the next five years to fund their viral respiratory infections-focused project. The award was given by the National Institute of Allergy and Infectious Diseases, which is part of the National Institute s of Health. The team of researchers — led by biology professor Kate… (Source: bizjournals.com Health Care:Biotechnology headlines)

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Local university researchers win $1.8M award to battle viral respiratory infections

A team of researchers at a local university could be making strides in viral respiratory infections research, thanks to new funding. Biology researchers at Wright State University will be receiving approximately $1.8 million over the next five years to fund their viral respiratory infections-focused project. The award was given by the National Institute of Allergy and Infectious Diseases, which is part of the National Institute s of Health. The team of researchers — led by biology professor Kate… (Source: bizjournals.com Health Care:Biotechnology headlines)

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State of Nevada Selects ImageTrend for Connected Health Records

LAKEVILLE, MINN. [September 10, 2018] - ImageTrend, Inc. announced the Nevada Department of Health and Human Services has selected ImageTrend for multiple solutions for the state's health information technology. The interconnected software will provide documentation and reporting for EMS, licensure of EMS care providers and healthcare data interoperability among hospitals, healthcare registries, EMS and HIEs. Karen Beckley, Bureau of Health Protection and Preparedness Chief said, "The new contract between the Division of Public and Behavioral Health, Emergency Medical Services Program and ImageTrend will facilitate increased communication, surveillance, monitoring and reporting of all emergency medical services incidents including data and information related to statewide opioid use...

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State of Nevada Selects ImageTrend for Connected Health Records

LAKEVILLE, MINN. [September 10, 2018] - ImageTrend, Inc. announced the Nevada Department of Health and Human Services has selected ImageTrend for multiple solutions for the state's health information technology. The interconnected software will provide documentation and reporting for EMS, licensure of EMS care providers and healthcare data interoperability among hospitals, healthcare registries, EMS and HIEs. Karen Beckley, Bureau of Health Protection and Preparedness Chief said, "The new contract between the Division of Public and Behavioral Health, Emergency Medical Services Program and ImageTrend will facilitate increased communication, surveillance, monitoring and reporting of all emergency medical services incidents including data and information related to statewide opioid use...

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Identification, expression and characterization of the recombinant Sol g 4.1 protein from the venom of the tropical fire ant Solenopsis geminata

Conclusions: The primary structure of Sol g 4.1 showed high similarity to that of venom proteins in the Solenopsis 2 and 4 family. Those proteins are life-threatening and produce IgE-mediated anaphylactic reactions in allergic individuals. The possible function of this protein is the binding of the interior hydrophobic pockets with piperidine alkaloids, as determined by the analysis of the structural model and PD50 test. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)

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Identification, expression and characterization of the recombinant Sol g 4.1 protein from the venom of the tropical fire ant Solenopsis geminata

Conclusions: The primary structure of Sol g 4.1 showed high similarity to that of venom proteins in the Solenopsis 2 and 4 family. Those proteins are life-threatening and produce IgE-mediated anaphylactic reactions in allergic individuals. The possible function of this protein is the binding of the interior hydrophobic pockets with piperidine alkaloids, as determined by the analysis of the structural model and PD50 test. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)

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Editorial Board

Publication date: September 2018Source: Veterinary Immunology and Immunopathology, Volume 203Author(s): (Source: Veterinary Immunology and Immunopathology)

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Editorial Board

Publication date: September 2018Source: Veterinary Immunology and Immunopathology, Volume 203Author(s): (Source: Veterinary Immunology and Immunopathology)

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Risk factors for and molecular characteristics of methicillin-resistant Staphylococcus aureus nasal colonization among healthy children in southern Taiwan, 2005–2010

ConclusionsBetween 2005 and 2010, 27.8% and 8.14% of healthy children in southern Taiwan had nasal carriage of S. aureus and MRSA, respectively. Most MRSA isolates were local community strains. Several demographic factors associated with nasal MRSA colonization were identified. (Source: Journal of Microbiology, Immunology and Infection)

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Risk factors for and molecular characteristics of methicillin-resistant Staphylococcus aureus nasal colonization among healthy children in southern Taiwan, 2005–2010

ConclusionsBetween 2005 and 2010, 27.8% and 8.14% of healthy children in southern Taiwan had nasal carriage of S. aureus and MRSA, respectively. Most MRSA isolates were local community strains. Several demographic factors associated with nasal MRSA colonization were identified. (Source: Journal of Microbiology, Immunology and Infection)

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S. mansoni Schistosomula Antigens Induce Th1/Proinflammatory Cytokine Responses

Parasite Immunology,Volume 0, Issue ja, -Not available-. (Source: Parasite Immunology)

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S. mansoni Schistosomula Antigens Induce Th1/Proinflammatory Cytokine Responses

Parasite Immunology,Volume 0, Issue ja, -Not available-. (Source: Parasite Immunology)

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Antibody Responses to Schistosoma mansoni Schistosomula Antigens

Parasite Immunology,Volume 0, Issue ja, -Not available-. (Source: Parasite Immunology)

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Antibody Responses to Schistosoma mansoni Schistosomula Antigens

Parasite Immunology,Volume 0, Issue ja, -Not available-. (Source: Parasite Immunology)

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IL ‐4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes

Microbiology and Immunology,Volume 0, Issue ja, -Not available-. (Source: Microbiology and Immunology)

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IL ‐4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes

Microbiology and Immunology,Volume 0, Issue ja, -Not available-. (Source: Microbiology and Immunology)

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Misconceptions and traditional practices towards infant teething symptoms among mothers in Southwest Ethiopia

Abstract

Background

The assumption of a link between common symptoms such as febrile illness, diarrhea and the eruption of primary teeth has been established over many centuries. According to traditional beliefs in Ethiopia, diarrhea and fever at the time of milk teeth eruption may be due to a worm in the child's gums. Current medical observations show little more than restlessness, drooling, and finger sucking resulting from teething. The purpose of this research was to assess mothers' traditional beliefs and practices towards teething symptoms.

Methods

A cross-sectional descriptive study design was used with the convenience sampling technique. Mothers were approached at the pediatric Out Patient Department (OPD) of Jimma University Specialized Hospital, southwest Ethiopia. A structured questionnaire was used for data collection. The data were analyzed by SPSS (version 20).

Results

A total of 107 mothers were interviewed. Ninety-eight (91.6%) claimed that teething was associated with various symptoms. Ninety-seven (90.7%) attributed diarrhea to teething. Only one mother said she would give her child Paracetamol to relieve the teething symptoms. Five (4.7%) mothers said they would allow their children to bite on a pacifier. Ten mothers (9.3%) said that they would prefer the child's milk tooth to be extracted. Some of the practices by mothers to relieve the symptoms include rubbing the gum of the child with garlic (12.1%) or rubbing the gum with herbs (6.5%).

Conclusions

Most of the mothers had misconceptions about the symptoms that usually appear during teething. Health education should be provided by dentists and professionals concerned with child care in correcting these misconceptions and cultural beliefs about teething symptoms.

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Misconceptions and traditional practices towards infant teething symptoms among mothers in Southwest Ethiopia

Abstract

Background

The assumption of a link between common symptoms such as febrile illness, diarrhea and the eruption of primary teeth has been established over many centuries. According to traditional beliefs in Ethiopia, diarrhea and fever at the time of milk teeth eruption may be due to a worm in the child's gums. Current medical observations show little more than restlessness, drooling, and finger sucking resulting from teething. The purpose of this research was to assess mothers' traditional beliefs and practices towards teething symptoms.

Methods

A cross-sectional descriptive study design was used with the convenience sampling technique. Mothers were approached at the pediatric Out Patient Department (OPD) of Jimma University Specialized Hospital, southwest Ethiopia. A structured questionnaire was used for data collection. The data were analyzed by SPSS (version 20).

Results

A total of 107 mothers were interviewed. Ninety-eight (91.6%) claimed that teething was associated with various symptoms. Ninety-seven (90.7%) attributed diarrhea to teething. Only one mother said she would give her child Paracetamol to relieve the teething symptoms. Five (4.7%) mothers said they would allow their children to bite on a pacifier. Ten mothers (9.3%) said that they would prefer the child's milk tooth to be extracted. Some of the practices by mothers to relieve the symptoms include rubbing the gum of the child with garlic (12.1%) or rubbing the gum with herbs (6.5%).

Conclusions

Most of the mothers had misconceptions about the symptoms that usually appear during teething. Health education should be provided by dentists and professionals concerned with child care in correcting these misconceptions and cultural beliefs about teething symptoms.

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Eighth Edition of AJCC/TNM Staging System Best at Detecting Survival in Thyroid Cancer

Eighth Edition of AJCC/TNM Staging System Best at Detecting Survival in Thyroid Cancer  Cancer NetworkFull coverage

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Eighth Edition of AJCC/TNM Staging System Best at Detecting Survival in Thyroid Cancer

Eighth Edition of AJCC/TNM Staging System Best at Detecting Survival in Thyroid Cancer  Cancer NetworkFull coverage

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Zimbabwe:Harare City Council Raids Vendors

[Zimbabwe Standard] Harare City Council and the national police yesterday launched raids against vendors in the central business district after pleas for the informal traders to leave the streets due to a cholera outbreak fell on deaf ears. (Source: AllAfrica News: Health and Medicine)

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Health Care 5 Under 40: Tina Penman

The local VA's expert in audiology is also exploring the role of blockchain and social media in health care. (Source: bizjournals.com Health Care:Physician Practices headlines)

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Zimbabwe:Harare City Council Raids Vendors

[Zimbabwe Standard] Harare City Council and the national police yesterday launched raids against vendors in the central business district after pleas for the informal traders to leave the streets due to a cholera outbreak fell on deaf ears. (Source: AllAfrica News: Health and Medicine)

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Health Care 5 Under 40: Tina Penman

The local VA's expert in audiology is also exploring the role of blockchain and social media in health care. (Source: bizjournals.com Health Care:Physician Practices headlines)

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Even with better prevention and earlier diagnosis, cancer will kill nearly 10 million people in 2018

Even with better prevention and earlier diagnosis, cancer will kill nearly 10 million people in 2018  ZME ScienceCancer prevention Tips:Reduce your cancer risk with diet and lifestyle changes  News HeadsFull coverage

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Even with better prevention and earlier diagnosis, cancer will kill nearly 10 million people in 2018

Even with better prevention and earlier diagnosis, cancer will kill nearly 10 million people in 2018  ZME ScienceCancer prevention Tips:Reduce your cancer risk with diet and lifestyle changes  News HeadsFull coverage

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Zimbabwe:Harare City Council Raids Vendors

[Zimbabwe Standard] Harare City Council and the national police yesterday launched raids against vendors in the central business district after pleas for the informal traders to leave the streets due to a cholera outbreak fell on deaf ears. (Source: AllAfrica News: Health and Medicine)

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Zimbabwe:Harare City Council Raids Vendors

[Zimbabwe Standard] Harare City Council and the national police yesterday launched raids against vendors in the central business district after pleas for the informal traders to leave the streets due to a cholera outbreak fell on deaf ears. (Source: AllAfrica News: Health and Medicine)

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Health Care 5 Under 40: Tina Penman

The local VA's expert in audiology is also exploring the role of blockchain and social media in health care. (Source: bizjournals.com Health Care:Physician Practices headlines)

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Health Care 5 Under 40: Tina Penman

The local VA's expert in audiology is also exploring the role of blockchain and social media in health care. (Source: bizjournals.com Health Care:Physician Practices headlines)

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Eosinophilic cystitis in children: A case report.

Authors: He J, Ning F, Tu L, Hu J, Chen W, Zhao Y Abstract The aim of the present case report was to investigate the clinical features, pathological examination and treatment of eosinophilic cystitis (EC) in children. Two cases of EC were reported and reviewed from January 2016 to March 2017. Case 1 (male; 6 years old) had intermittent hematuria, frequent urination, urgent urination, difficulty in urination and abdominal pain. Case 2 (male; 7 years old) had frequent urination, urgent urination, urinary pain, dysuria and suprapubic pain with no hematuria. One patient had a history of allergies and both patients underwent a cystoscope biopsy. Blood eosinophils were clearly increased and a bone marrow biopsy examination revealed that marrow eosinophils were also increased in both case...

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Sinus Augmentation Failure and Postoperative Infections Associated with Prophylactic Clindamycin Therapy: An Observational Case Series.

CONCLUSION: Prophylactic clindamycin therapy following sinus augmentation procedures seems to be a risk factor for infections and loss of grafting material following these surgical techniques. PMID: 30231102 [PubMed - in process] (Source: International Journal of Oral and Maxillofacial Implants)

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Eosinophilic cystitis in children: A case report.

Authors: He J, Ning F, Tu L, Hu J, Chen W, Zhao Y Abstract The aim of the present case report was to investigate the clinical features, pathological examination and treatment of eosinophilic cystitis (EC) in children. Two cases of EC were reported and reviewed from January 2016 to March 2017. Case 1 (male; 6 years old) had intermittent hematuria, frequent urination, urgent urination, difficulty in urination and abdominal pain. Case 2 (male; 7 years old) had frequent urination, urgent urination, urinary pain, dysuria and suprapubic pain with no hematuria. One patient had a history of allergies and both patients underwent a cystoscope biopsy. Blood eosinophils were clearly increased and a bone marrow biopsy examination revealed that marrow eosinophils were also increased in both case...

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Concerted IL-25R and IL-4R α signaling drive innate type 2 effector immunity for optimal helminth expulsion

Interleukin 25 (IL-25) is a major 'alarmin' cytokine, capable of initiating and amplifying the type 2 immune response to helminth parasites. However its role in the later effector phase of clearing chronic infection remains unclear. The helminthHeligmosomoides polygyrus establishes long-term infections in susceptible C57BL/6 mice, but is slowly expelled in BALB/c mice from day 14 onwards. We noted that IL-25R (Il17rb)-deficient BALB/c mice were unable to expel parasites despite type 2 immune activation comparable to the wild-type. We then established that in C57BL/6 mice, IL-25 adminstered late in infection (days 14-17) drove immunity. Moreover when IL-25 and IL-4 were delivered toRag1-deficient mice, the combination resulted in near complete expulsion of the parasite, even following admin...

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Sinus Augmentation Failure and Postoperative Infections Associated with Prophylactic Clindamycin Therapy: An Observational Case Series.

CONCLUSION: Prophylactic clindamycin therapy following sinus augmentation procedures seems to be a risk factor for infections and loss of grafting material following these surgical techniques. PMID: 30231102 [PubMed - in process] (Source: International Journal of Oral and Maxillofacial Implants)

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