The Methodology and Electro-physiological Classification of Pre-operative Trans-tympanic Electrically-Evoked Auditory Brainstem Response (TT-EABR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2B5NZlY

The Methodology and Electro-physiological Classification of Pre-operative Trans-tympanic Electrically-Evoked Auditory Brainstem Response (TT-EABR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2B5NZlY

Immunogenicity and Safety Study of Inactivated Subunit H5N1 Influenza Vaccine in Prior Recipients of Live Attenuated H2N2, H6N1 and H9N2 Influenza Vaccines and in H5N1 and Live Attenuated Vaccine Na ïve Individuals

Condition:   Influenza Intervention:   Biological: H5N1 pISV Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rl3BXX

Iron and Pollen Allergy in Women

Conditions:   Allergy Pollen;   Healthy Interventions:   Dietary Supplement: ImmunoBon;   Dietary Supplement: Placebo Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WqAE0S

Siderophore-profile in Allergic and Non-allergic Subjects

Conditions:   Allergy;   Healthy;   Allergic Sensitisation Intervention:   Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RlqV83

Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine, VRCFLUNPF099-00-VP, in Healthy Adults

Condition:   Influenza Interventions:   Other: VRC-PBSPLA043-00-VP (phosphate buffered saline);   Biological: VRC-FLUNPF099-00-VP (H1ssF_3928) Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Wnozti

What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?

Conditions:   Invasive Pneumococcal Disease, Recurrent Isolated, 1;   Invasive Pneumococcal Disease, Recurrent Isolated, 2;   Invasive Pneumococcal Disease, Protection Against;   Primary Immunodeficiency Intervention:   Other: Referral to Immunology Sponsor:   Murdoch Childrens Research Institute Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rl9iVR

A Randomized Experiment of Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: the TESTsmART Trial Aim 1

Conditions:   Malaria;   Febrile Illness Interventions:   Other: Conditional ACT subsidy, Arm 1 levels;   Other: Conditional ACT subsidy, Arm 2 levels;   Other: Conditional ACT subsidy, Arm 3 levels;   Other: Conditional ACT subsidy, Arm 4 levels Sponsors:   Duke University;   National Institute of Allergy and Infectious Diseases (NIAID);   Moi University;   Clinton Health Access Initiative, Nigeria Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WnoyWg

Effects of Vaginal Seeding on Infants' Body Mass Index and Allergy Risk for Caesarean-delivered Children

Conditions:   Overweight and Obesity;   Allergy Intervention:   Procedure: Vaginal seeding Sponsors:   Peking University;   National Natural Science Foundation of China;   Liuyang Maternal and Child Health Care Hospital Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RlqHhd

Interobserver agreement of skeletal muscle mass measurement on head and neck CT imaging at the level of the third cervical vertebra

Abstract

Objectives

Skeletal muscle mass (SMM) is most often assessed in cancer patients on abdominal computed tomography (CT) imaging at the level of the third lumbar vertebra (L3). Abdominal CT imaging is not routinely performed in head and neck cancer (HNC) patients. Recently, a novel method to assess SMM on a single transversal CT slice at the level of the third cervical vertebra (C3) was published. The objective of this study was to assess the robustness of this novel C3 measurement method in terms of interobserver agreement.

Patients and methods

Patients diagnosed with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) at our center between 2007 and 2011 were evaluated. Fifty-four patients with were randomly selected for analysis. Six observers independently measured the cross-sectional muscle area (CSMA) at the level of C3 using a predefined, written protocol as instruction. Interobserver agreement was assessed using intraclass correlation coefficients (ICCs), a Bland–Altman plot and Fleiss' kappa (κ).

Results

The agreement in vertebra selection between all observers was excellent (Fleiss' κ: 0.96). There was a substantial agreement between all observers in single slice selection (Fleiss' κ: 0.61). For all CSMA measurements, ICCs were excellent (0.763–0.969; all p < 0.001). The Bland–Altman plot showed good agreement between measurements, with narrow limits of agreement.

Conclusion

Interobserver agreement for SMM measurement at the level of C3 was excellent. Assessment of SMM at the level of C3 is easy and robust and can performed on routinely available imaging in HNC patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ThF6gp

Clinical Study of Minimally Invasive Ponto Surgical Technique (MIPS) - Design Iteration

Conditions:   Bone Conduction Deafness;   Unilateral Deafness;   Middle Ear Deafness;   Mixed Hearing Loss Intervention:   Device: Minimally Invasive Ponto Surgery Sponsor:   Oticon Medical Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Wnf8db

Exploring the Use of ECochG Testing During Electrode Insertion in Cochlear Implant Surgery

Conditions:   Cochlear Implants;   Hearing Preservation Intervention:   Procedure: Electrocochlography Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RmnXjE

Immunogenicity and Safety Study of Inactivated Subunit H5N1 Influenza Vaccine in Prior Recipients of Live Attenuated H2N2, H6N1 and H9N2 Influenza Vaccines and in H5N1 and Live Attenuated Vaccine Na ïve Individuals

Condition:   Influenza Intervention:   Biological: H5N1 pISV Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rl3BXX

Iron and Pollen Allergy in Women

Conditions:   Allergy Pollen;   Healthy Interventions:   Dietary Supplement: ImmunoBon;   Dietary Supplement: Placebo Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WqAE0S

Siderophore-profile in Allergic and Non-allergic Subjects

Conditions:   Allergy;   Healthy;   Allergic Sensitisation Intervention:   Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RlqV83

Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine, VRCFLUNPF099-00-VP, in Healthy Adults

Condition:   Influenza Interventions:   Other: VRC-PBSPLA043-00-VP (phosphate buffered saline);   Biological: VRC-FLUNPF099-00-VP (H1ssF_3928) Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Wnozti

What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?

Conditions:   Invasive Pneumococcal Disease, Recurrent Isolated, 1;   Invasive Pneumococcal Disease, Recurrent Isolated, 2;   Invasive Pneumococcal Disease, Protection Against;   Primary Immunodeficiency Intervention:   Other: Referral to Immunology Sponsor:   Murdoch Childrens Research Institute Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rl9iVR

A Randomized Experiment of Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: the TESTsmART Trial Aim 1

Conditions:   Malaria;   Febrile Illness Interventions:   Other: Conditional ACT subsidy, Arm 1 levels;   Other: Conditional ACT subsidy, Arm 2 levels;   Other: Conditional ACT subsidy, Arm 3 levels;   Other: Conditional ACT subsidy, Arm 4 levels Sponsors:   Duke University;   National Institute of Allergy and Infectious Diseases (NIAID);   Moi University;   Clinton Health Access Initiative, Nigeria Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WnoyWg

Effects of Vaginal Seeding on Infants' Body Mass Index and Allergy Risk for Caesarean-delivered Children

Conditions:   Overweight and Obesity;   Allergy Intervention:   Procedure: Vaginal seeding Sponsors:   Peking University;   National Natural Science Foundation of China;   Liuyang Maternal and Child Health Care Hospital Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RlqHhd

Interobserver agreement of skeletal muscle mass measurement on head and neck CT imaging at the level of the third cervical vertebra

Abstract

Objectives

Skeletal muscle mass (SMM) is most often assessed in cancer patients on abdominal computed tomography (CT) imaging at the level of the third lumbar vertebra (L3). Abdominal CT imaging is not routinely performed in head and neck cancer (HNC) patients. Recently, a novel method to assess SMM on a single transversal CT slice at the level of the third cervical vertebra (C3) was published. The objective of this study was to assess the robustness of this novel C3 measurement method in terms of interobserver agreement.

Patients and methods

Patients diagnosed with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) at our center between 2007 and 2011 were evaluated. Fifty-four patients with were randomly selected for analysis. Six observers independently measured the cross-sectional muscle area (CSMA) at the level of C3 using a predefined, written protocol as instruction. Interobserver agreement was assessed using intraclass correlation coefficients (ICCs), a Bland–Altman plot and Fleiss' kappa (κ).

Results

The agreement in vertebra selection between all observers was excellent (Fleiss' κ: 0.96). There was a substantial agreement between all observers in single slice selection (Fleiss' κ: 0.61). For all CSMA measurements, ICCs were excellent (0.763–0.969; all p < 0.001). The Bland–Altman plot showed good agreement between measurements, with narrow limits of agreement.

Conclusion

Interobserver agreement for SMM measurement at the level of C3 was excellent. Assessment of SMM at the level of C3 is easy and robust and can performed on routinely available imaging in HNC patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ThF6gp

Clinical Study of Minimally Invasive Ponto Surgical Technique (MIPS) - Design Iteration

Conditions:   Bone Conduction Deafness;   Unilateral Deafness;   Middle Ear Deafness;   Mixed Hearing Loss Intervention:   Device: Minimally Invasive Ponto Surgery Sponsor:   Oticon Medical Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Wnf8db

Exploring the Use of ECochG Testing During Electrode Insertion in Cochlear Implant Surgery

Conditions:   Cochlear Implants;   Hearing Preservation Intervention:   Procedure: Electrocochlography Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RmnXjE

Effect of internal derangements and degenerative bone changes on the minimum thickness of the roof of the glenoid fossa in temporomandibular joint

Abstract

Objectives

The aim of this study is to investigate the effect of internal derangements and degenerative bone changes on the minimum thickness of the roof of the glenoid fossa (RGF).

Methods

MRI and cone beam CT records of temporomandibular joints (TMJ) of 68 patients were evaluated retrospectively in this study. The joints were divided into three groups according to TMJ disc status which had been diagnosed in MRI: normal disc status, anterior disc displacement with reduction, and anterior disc displacement without reduction. Cone beam CT was used to evaluate the degenerative bone changes of TMJ and to measure the minimum thickness of RGF. The joints were categorized as "with osteoarthritis (OA)" or "without OA". The findings of OA were determined as erosion, osteophyte, flattening, sclerosis, and pseudocyst.

Results

No significant relationship was found between gender and the thickness of RGF (p > 0.05). RGF was found significantly higher in "with OA" group compared to "without OA" group (p < 0.001). No significant difference was found between disc displacement groups for minimum thickness of RGF (p > 0.005). No significant difference was found between condyles without erosion and condyles with erosion for the minimum thickness of RGF (p = 0.272). In the present study, osteophyte, sclerosis, flattening, and pseudocyst were found to be associated with the minimum thickness of RGF.

Conclusions

Osteophyte, flattening, pseudocyst, and sclerosis have an influence on RGF thickness. The minimum thickness of RGF is not significantly correlated with internal derangements. Erosion is not significantly correlated with RGF thickness. RGF thickness may be unaffected by the early stages of OA.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sa8nft

Effect of internal derangements and degenerative bone changes on the minimum thickness of the roof of the glenoid fossa in temporomandibular joint

Abstract

Objectives

The aim of this study is to investigate the effect of internal derangements and degenerative bone changes on the minimum thickness of the roof of the glenoid fossa (RGF).

Methods

MRI and cone beam CT records of temporomandibular joints (TMJ) of 68 patients were evaluated retrospectively in this study. The joints were divided into three groups according to TMJ disc status which had been diagnosed in MRI: normal disc status, anterior disc displacement with reduction, and anterior disc displacement without reduction. Cone beam CT was used to evaluate the degenerative bone changes of TMJ and to measure the minimum thickness of RGF. The joints were categorized as "with osteoarthritis (OA)" or "without OA". The findings of OA were determined as erosion, osteophyte, flattening, sclerosis, and pseudocyst.

Results

No significant relationship was found between gender and the thickness of RGF (p > 0.05). RGF was found significantly higher in "with OA" group compared to "without OA" group (p < 0.001). No significant difference was found between disc displacement groups for minimum thickness of RGF (p > 0.005). No significant difference was found between condyles without erosion and condyles with erosion for the minimum thickness of RGF (p = 0.272). In the present study, osteophyte, sclerosis, flattening, and pseudocyst were found to be associated with the minimum thickness of RGF.

Conclusions

Osteophyte, flattening, pseudocyst, and sclerosis have an influence on RGF thickness. The minimum thickness of RGF is not significantly correlated with internal derangements. Erosion is not significantly correlated with RGF thickness. RGF thickness may be unaffected by the early stages of OA.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sa8nft

Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases

Abstract

Background

Over 1 billion people suffer from chronic respiratory diseases such as asthma, COPD, rhinitis and rhinosinusitis. They cause an enormous burden and are considered as major non-communicable diseases. Many patients are still uncontrolled and the cost of inaction is unacceptable. A meeting was held in Vilnius, Lithuania (March 23, 2018) under the patronage of the Ministry of Health and several scientific societies to propose multisectoral care pathways embedding guided self-management, mHealth and air pollution in selected chronic respiratory diseases (rhinitis, chronic rhinosinusitis, asthma and COPD). The meeting resulted in the Vilnius Declaration that was developed by the participants of the EU Summit on chronic respiratory diseases under the leadership of Euforea.

Conclusion

The Vilnius Declaration represents an important step for the fight against air pollution in chronic respiratory diseases globally and has a clear strategic relevance with regard to the EU Health Strategy as it will bring added value to the existing public health knowledge.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RRrHPj

Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases

Abstract

Background

Over 1 billion people suffer from chronic respiratory diseases such as asthma, COPD, rhinitis and rhinosinusitis. They cause an enormous burden and are considered as major non-communicable diseases. Many patients are still uncontrolled and the cost of inaction is unacceptable. A meeting was held in Vilnius, Lithuania (March 23, 2018) under the patronage of the Ministry of Health and several scientific societies to propose multisectoral care pathways embedding guided self-management, mHealth and air pollution in selected chronic respiratory diseases (rhinitis, chronic rhinosinusitis, asthma and COPD). The meeting resulted in the Vilnius Declaration that was developed by the participants of the EU Summit on chronic respiratory diseases under the leadership of Euforea.

Conclusion

The Vilnius Declaration represents an important step for the fight against air pollution in chronic respiratory diseases globally and has a clear strategic relevance with regard to the EU Health Strategy as it will bring added value to the existing public health knowledge.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RRrHPj

Eco-friendly green synthesis of silver nanoparticles from the sesame oil cake and its potential anticancer and antimicrobial activities

Publication date: Available online 26 January 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Akram A. Alfuraydi, Sandanasamy Devanesan, Mysoon Al-Ansari, Mohamad S. AlSalhi, Amirtham J. RanjitsinghAbstractIn recent years, much attention is focused on silver nanoparticles for biomedical applications and then synthesis using plant procedure has drawn a great focus. In the current study silver nanoparticles were synthesized using the oil cake of Sesamumindicum, which has been used traditionally for several therapeutic purposes. Silver nanoparticles (NPs) were synthesizedin the presence of sesame oil cake. The sesame oil cake facilitated the biosynthesis of silver nanoparticles (SCAgNPs). The synthesized SCAgNPs were subjected to several studies using UV-Visspectro...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WfIKZU

Editorial Board

Publication date: February 2019Source: Journal of Photochemistry and Photobiology B: Biology, Volume 191Author(s): (Source: Journal of Photochemistry and Photobiology B: Biology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DBX08a

The Intonation and Pragmatics of Greek wh-Questions.

Authors: Baltazani M, Gryllia S, Arvaniti A Abstract We experimentally tested three hypotheses regarding the pragmatics of two tunes (one high-ending, one flat-ending) used with Greek wh-questions: (a) the high-ending tune is associated with information-seeking questions, while the flat-ending tune is also appropriate when wh-questions are not information-seeking, in which case their function can instead be akin to that of a statement; (b) the high-ending tune is more polite, and (c) more appropriate for contexts leading to information-seeking questions. The wh-questions used as experimental stimuli were elicited from four speakers in contexts likely to lead to either information-seeking or non-information-seeking uses. The speakers produced distinct tunes in response to the contex...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UjBNVT

Eco-friendly green synthesis of silver nanoparticles from the sesame oil cake and its potential anticancer and antimicrobial activities

Publication date: Available online 26 January 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Akram A. Alfuraydi, Sandanasamy Devanesan, Mysoon Al-Ansari, Mohamad S. AlSalhi, Amirtham J. RanjitsinghAbstractIn recent years, much attention is focused on silver nanoparticles for biomedical applications and then synthesis using plant procedure has drawn a great focus. In the current study silver nanoparticles were synthesized using the oil cake of Sesamumindicum, which has been used traditionally for several therapeutic purposes. Silver nanoparticles (NPs) were synthesizedin the presence of sesame oil cake. The sesame oil cake facilitated the biosynthesis of silver nanoparticles (SCAgNPs). The synthesized SCAgNPs were subjected to several studies using UV-Visspectro...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WfIKZU

Editorial Board

Publication date: February 2019Source: Journal of Photochemistry and Photobiology B: Biology, Volume 191Author(s): (Source: Journal of Photochemistry and Photobiology B: Biology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DBX08a

The Intonation and Pragmatics of Greek wh-Questions.

Authors: Baltazani M, Gryllia S, Arvaniti A Abstract We experimentally tested three hypotheses regarding the pragmatics of two tunes (one high-ending, one flat-ending) used with Greek wh-questions: (a) the high-ending tune is associated with information-seeking questions, while the flat-ending tune is also appropriate when wh-questions are not information-seeking, in which case their function can instead be akin to that of a statement; (b) the high-ending tune is more polite, and (c) more appropriate for contexts leading to information-seeking questions. The wh-questions used as experimental stimuli were elicited from four speakers in contexts likely to lead to either information-seeking or non-information-seeking uses. The speakers produced distinct tunes in response to the contex...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UjBNVT

Toward Optimizing cVEMP: 2,000-Hz Tone Bursts Improve the Detection of Superior Canal Dehiscence

Conclusion: The best diagnostic accuracy of cVEMP in SCD patients can be achieved with 2,000-Hz tone burst stimuli, regardless of which metric is used.Audiol Neurotol 2018;23:335 –344 (Source: Audiology and Neurotology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Uk607p

Histopathology of the Inner Ear in Charcot-Marie-Tooth Syndrome Caused by a Missense Variant (p.Thr65Ala) in the < b > < i > MPZ < /i > < /b > Gene

Charcot-Marie-Tooth (CMT) syndrome is a clinically and genetically heterogeneous group of neuropathies affecting both peripheral motor and sensory nerves. Progressive sensorineural hearing loss, vestibular abnormalities, and dysfunction of other cranial nerves have been described. This is the second case report of otopathology in a patient with CMT syndrome. Molecular genetic testing of DNA obtained at autopsy revealed a missense variant in theMPZ gene (p.Thr65Ala), pathogenic for an autosomal-dominant form of CMT1B. The temporal bones were also prepared for light microscopy by hematoxylin and eosin and G ömöri trichome stains, and immunostaining for anti-myelin protein zero. Pathology was consistent with a myelinopathy of the auditory, vestibular, and facial nerves bilaterally. The path...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DE5QCh

Primary coenzyme Q10 Deficiency-6 (COQ10D6): Two siblings with variable expressivity of the renal phenotype.

Authors: Yildirim ZY, Toksoy G, Uyguner O, Nayir A, Yavuz S, Altunoglu U, Turkkan ON, Sevinc B, Gokcay G, Gunes DK, Kiyak A, Yilmaz A Abstract Primary coenzyme Q10 deficiency-6 (COQ10D6) is a rare autosomal recessive disorder caused by COQ6 mutations. The main clinical manifestations are infantile progressive nephrotic syndrome (NS) leading to end-stage renal disease and sensorineural deafness. A 7-year-old girl was diagnosed with steroid-resistant NS (SRNS) and an audiological work-up revealed bilateral sensorineural deafness. A renal biopsy demonstrated focal segmental glomerulosclerosis. Despite immunosuppressive therapy, her serum levels of creatinine increased and haemodialysis was indicated within 1 year after the diagnosis. Living-donor kidney transplantation was performed i...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Uk5TZx

Toward Optimizing cVEMP: 2,000-Hz Tone Bursts Improve the Detection of Superior Canal Dehiscence

Conclusion: The best diagnostic accuracy of cVEMP in SCD patients can be achieved with 2,000-Hz tone burst stimuli, regardless of which metric is used.Audiol Neurotol 2018;23:335 –344 (Source: Audiology and Neurotology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Uk607p

Histopathology of the Inner Ear in Charcot-Marie-Tooth Syndrome Caused by a Missense Variant (p.Thr65Ala) in the < b > < i > MPZ < /i > < /b > Gene

Charcot-Marie-Tooth (CMT) syndrome is a clinically and genetically heterogeneous group of neuropathies affecting both peripheral motor and sensory nerves. Progressive sensorineural hearing loss, vestibular abnormalities, and dysfunction of other cranial nerves have been described. This is the second case report of otopathology in a patient with CMT syndrome. Molecular genetic testing of DNA obtained at autopsy revealed a missense variant in theMPZ gene (p.Thr65Ala), pathogenic for an autosomal-dominant form of CMT1B. The temporal bones were also prepared for light microscopy by hematoxylin and eosin and G ömöri trichome stains, and immunostaining for anti-myelin protein zero. Pathology was consistent with a myelinopathy of the auditory, vestibular, and facial nerves bilaterally. The path...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DE5QCh

Primary coenzyme Q10 Deficiency-6 (COQ10D6): Two siblings with variable expressivity of the renal phenotype.

Authors: Yildirim ZY, Toksoy G, Uyguner O, Nayir A, Yavuz S, Altunoglu U, Turkkan ON, Sevinc B, Gokcay G, Gunes DK, Kiyak A, Yilmaz A Abstract Primary coenzyme Q10 deficiency-6 (COQ10D6) is a rare autosomal recessive disorder caused by COQ6 mutations. The main clinical manifestations are infantile progressive nephrotic syndrome (NS) leading to end-stage renal disease and sensorineural deafness. A 7-year-old girl was diagnosed with steroid-resistant NS (SRNS) and an audiological work-up revealed bilateral sensorineural deafness. A renal biopsy demonstrated focal segmental glomerulosclerosis. Despite immunosuppressive therapy, her serum levels of creatinine increased and haemodialysis was indicated within 1 year after the diagnosis. Living-donor kidney transplantation was performed i...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Uk5TZx

Clinical Thyroidology® for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Adding mycophenolate to infusions of methylprednisolone improves treatment of Graves' eye disease. Read More…

We welcome your feedback and suggestions. Let us know what you want to see in this publication.

Feedback & Suggestions

The post Clinical Thyroidology^® for the Public – Highlighted Article appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UkdQxF

Clinical Thyroidology® for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Adding mycophenolate to infusions of methylprednisolone improves treatment of Graves' eye disease. Read More…

We welcome your feedback and suggestions. Let us know what you want to see in this publication.

Feedback & Suggestions

The post Clinical Thyroidology^® for the Public – Highlighted Article appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UkdQxF

Clinical Thyroidology® for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Adding mycophenolate to infusions of methylprednisolone improves treatment of Graves' eye disease. Read More…

We welcome your feedback and suggestions. Let us know what you want to see in this publication.

Feedback & Suggestions

The post Clinical Thyroidology^® for the Public – Highlighted Article appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UkdQxF

Clinical Thyroidology® for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Adding mycophenolate to infusions of methylprednisolone improves treatment of Graves' eye disease. Read More…

We welcome your feedback and suggestions. Let us know what you want to see in this publication.

Feedback & Suggestions

The post Clinical Thyroidology^® for the Public – Highlighted Article appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UkdQxF

Efficacy of a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate, Delivered in a Single Spray, for the Treatment of Seasonal Allergic Rhinitis: Results from Russia

Conclusions: MP-AzeFlu was superior to AZE in reducing moderate-to-severe SAR symptoms, providing earlier and more complete symptom relief.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Hy84XG

Peanut Allergy in Spanish Children: Comparative Profile of Peanut Allergy versus Tolerance

Conclusions: In our population, the peanut-allergic children were mainly sensitized to peanut storage proteins, and Ara h 2 sensitization allows a more accurate diagnosis of clinical reactivity to peanuts. More than half of the peanut-allergic patients were sensitized to peach Pru p 3, and 50% of them had fruit allergy at the time of the study.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ScATgG

Efficacy of a Novel Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate, Delivered in a Single Spray, for the Treatment of Seasonal Allergic Rhinitis: Results from Russia

Conclusions: MP-AzeFlu was superior to AZE in reducing moderate-to-severe SAR symptoms, providing earlier and more complete symptom relief.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Hy84XG

Peanut Allergy in Spanish Children: Comparative Profile of Peanut Allergy versus Tolerance

Conclusions: In our population, the peanut-allergic children were mainly sensitized to peanut storage proteins, and Ara h 2 sensitization allows a more accurate diagnosis of clinical reactivity to peanuts. More than half of the peanut-allergic patients were sensitized to peach Pru p 3, and 50% of them had fruit allergy at the time of the study.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ScATgG

Predictive value of hyoid cephalometrics for retroglossal obstruction in patients with obstructive sleep apnoea hypopnea syndrome.

Related Articles

Predictive value of hyoid cephalometrics for retroglossal obstruction in patients with obstructive sleep apnoea hypopnea syndrome.

J Laryngol Otol. 2019 Jan 25;:1-6

Authors: Hei RY, Qin J, Li SH

Abstract
OBJECTIVE: To examine the diagnostic value of hyoid cephalometrics in predicting retroglossal obstruction severity in patients with obstructive sleep apnoea hypopnea syndrome.
METHODS: Ninety-six obstructive sleep apnoea hypopnea syndrome patients diagnosed by polysomnography were recruited. Polysomnography was repeated with a nasopharyngeal tube after eliminating rhinal and palatopharyngeal obstruction. Cervical vertebra lateral films and hyoid cephalometric measurements were obtained, including the distances of the hyoid to the: mental tubercle, prevertebral plane, mental tubercle coronal plane and mental tubercle horizontal plane.
RESULTS: The apnoea-hypopnoea index for nasopharyngeal tube polysomnography was significantly correlated with distances from the hyoid to: prevertebral plane (r = 0.350), coronal plane (r = 0.477), horizontal plane (r = 0.529) and mental tubercle (r = 0.560). It was strongly correlated with the hyoid to mental tubercle distance/hyoid to prevertebral plane distance value (r = 0.683), and (hyoid to coronal plane distance plus hyoid to horizontal plane distance)/hyoid to prevertebral plane distance value (r = 0.675).
CONCLUSION: Obstructive sleep apnoea hypopnea syndrome patients with longer hyoid to mental tubercle distances, and/or more inferior and posterior hyoid bone position, are more prone to retroglossal stenosis and obstruction. Hyoid cephalometrics are valuable for predicting retroglossal obstruction severity.

PMID: 30681044 [PubMed - as supplied by publisher]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DBUT4d

Predictive value of hyoid cephalometrics for retroglossal obstruction in patients with obstructive sleep apnoea hypopnea syndrome.

Related Articles

Predictive value of hyoid cephalometrics for retroglossal obstruction in patients with obstructive sleep apnoea hypopnea syndrome.

J Laryngol Otol. 2019 Jan 25;:1-6

Authors: Hei RY, Qin J, Li SH

Abstract
OBJECTIVE: To examine the diagnostic value of hyoid cephalometrics in predicting retroglossal obstruction severity in patients with obstructive sleep apnoea hypopnea syndrome.
METHODS: Ninety-six obstructive sleep apnoea hypopnea syndrome patients diagnosed by polysomnography were recruited. Polysomnography was repeated with a nasopharyngeal tube after eliminating rhinal and palatopharyngeal obstruction. Cervical vertebra lateral films and hyoid cephalometric measurements were obtained, including the distances of the hyoid to the: mental tubercle, prevertebral plane, mental tubercle coronal plane and mental tubercle horizontal plane.
RESULTS: The apnoea-hypopnoea index for nasopharyngeal tube polysomnography was significantly correlated with distances from the hyoid to: prevertebral plane (r = 0.350), coronal plane (r = 0.477), horizontal plane (r = 0.529) and mental tubercle (r = 0.560). It was strongly correlated with the hyoid to mental tubercle distance/hyoid to prevertebral plane distance value (r = 0.683), and (hyoid to coronal plane distance plus hyoid to horizontal plane distance)/hyoid to prevertebral plane distance value (r = 0.675).
CONCLUSION: Obstructive sleep apnoea hypopnea syndrome patients with longer hyoid to mental tubercle distances, and/or more inferior and posterior hyoid bone position, are more prone to retroglossal stenosis and obstruction. Hyoid cephalometrics are valuable for predicting retroglossal obstruction severity.

PMID: 30681044 [PubMed - as supplied by publisher]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DBUT4d

Thermally reversible photochromism of dipyrrolylethenes

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00557E, Paper

Kohei Inaba, Ryota Iwai, Masakazu Morimoto, Masahiro Irie
Although diarylethene derivatives are considered to undergo thermally irreversible photochromic reactions, this is not always the case. Here we report on thermally reversible photochromic diarylethenes having pyrrole-2-carbonitrile aryl groups. Thermal...
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2G0jIIF

Thermally reversible photochromism of dipyrrolylethenes

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00557E, Paper

Kohei Inaba, Ryota Iwai, Masakazu Morimoto, Masahiro Irie
Although diarylethene derivatives are considered to undergo thermally irreversible photochromic reactions, this is not always the case. Here we report on thermally reversible photochromic diarylethenes having pyrrole-2-carbonitrile aryl groups. Thermal...
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2G0jIIF

Automatic classification and removal of structured physiological noise for resting state functional connectivity MRI analysis

Publication date: Available online 26 January 2019

Source: Magnetic Resonance Imaging

Author(s): Kangjoo Lee, Hui Ming Khoo, Constance Fourcade, Jean Gotman, Christophe Grova

Abstract

Resting state functional magnetic resonance imaging is used to study how brain regions are functionally connected by measuring temporal correlation of the fMRI signals, when a subject is at rest. Sparse dictionary learning is used to estimate a dictionary of resting state networks by decomposing the whole brain signals into several temporal features (atoms), each being shared by a set of voxels associated to a network. Recently, we proposed and validated a new method entitled Sparsity-based Analysis of Reliable K-hubness (SPARK), suggesting that connector hubs of brain networks participating in inter-network communication can be identified by counting the number of atoms involved in each voxel (sparse number k). However, such hub analysis can be corrupted by the presence of noise-related atoms, where physiological fluctuations in cardiorespiratory processes may remain even after band-pass filtering and regression of confound signals from the white matter and cerebrospinal fluid. Handling this issue might require manual classification of noisy atoms, which is a time-consuming and subjective task. Motivated by the fact that the physiological fluctuations are often localized in tissues close to large vasculatures, i.e. sagittal sinus, we propose an automatic classification of physiological noise-related atoms for SPARK using spatial priors and a stepwise regression procedure. We measured the degree to which the noise-characteristic time-courses within the mask are explained by each atom, and classified noise-related atoms using a subject-specific threshold estimated using a bootstrap resampling based strategy. Using real data from healthy subjects (N = 25), manual classification of the atoms by two independent reviewers showed the presence of sagittal sinus related noise in 65% of the runs. Applying the same manual classification after the proposed automatic removal method reduced this rate to 19%. A 10-fold cross-validation on real data showed good specificity and accuracy of the proposed automated method in classifying the target noise (area under the ROC curve= 0.89), when compared to the manual classification considered as the reference. We demonstrated decrease in k-hubness values in the voxels involved in the sagittal sinus at both individual and group levels, suggesting a significant improvement of SPARK, which is particularly important when considering clinical applications.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MyHqwM

Automatic classification and removal of structured physiological noise for resting state functional connectivity MRI analysis

Publication date: Available online 26 January 2019

Source: Magnetic Resonance Imaging

Author(s): Kangjoo Lee, Hui Ming Khoo, Constance Fourcade, Jean Gotman, Christophe Grova

Abstract

Resting state functional magnetic resonance imaging is used to study how brain regions are functionally connected by measuring temporal correlation of the fMRI signals, when a subject is at rest. Sparse dictionary learning is used to estimate a dictionary of resting state networks by decomposing the whole brain signals into several temporal features (atoms), each being shared by a set of voxels associated to a network. Recently, we proposed and validated a new method entitled Sparsity-based Analysis of Reliable K-hubness (SPARK), suggesting that connector hubs of brain networks participating in inter-network communication can be identified by counting the number of atoms involved in each voxel (sparse number k). However, such hub analysis can be corrupted by the presence of noise-related atoms, where physiological fluctuations in cardiorespiratory processes may remain even after band-pass filtering and regression of confound signals from the white matter and cerebrospinal fluid. Handling this issue might require manual classification of noisy atoms, which is a time-consuming and subjective task. Motivated by the fact that the physiological fluctuations are often localized in tissues close to large vasculatures, i.e. sagittal sinus, we propose an automatic classification of physiological noise-related atoms for SPARK using spatial priors and a stepwise regression procedure. We measured the degree to which the noise-characteristic time-courses within the mask are explained by each atom, and classified noise-related atoms using a subject-specific threshold estimated using a bootstrap resampling based strategy. Using real data from healthy subjects (N = 25), manual classification of the atoms by two independent reviewers showed the presence of sagittal sinus related noise in 65% of the runs. Applying the same manual classification after the proposed automatic removal method reduced this rate to 19%. A 10-fold cross-validation on real data showed good specificity and accuracy of the proposed automated method in classifying the target noise (area under the ROC curve= 0.89), when compared to the manual classification considered as the reference. We demonstrated decrease in k-hubness values in the voxels involved in the sagittal sinus at both individual and group levels, suggesting a significant improvement of SPARK, which is particularly important when considering clinical applications.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MyHqwM

Clinical Study of Minimally Invasive Ponto Surgical Technique (MIPS) - Design Iteration

Conditions:   Bone Conduction Deafness;   Unilateral Deafness;   Middle Ear Deafness;   Mixed Hearing Loss Intervention:   Device: Minimally Invasive Ponto Surgery Sponsor:   Oticon Medical Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MBQ2mn

Exploring the Use of ECochG Testing During Electrode Insertion in Cochlear Implant Surgery

Conditions:   Cochlear Implants;   Hearing Preservation Intervention:   Procedure: Electrocochlography Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sRKueg

Clinical Study of Minimally Invasive Ponto Surgical Technique (MIPS) - Design Iteration

Conditions:   Bone Conduction Deafness;   Unilateral Deafness;   Middle Ear Deafness;   Mixed Hearing Loss Intervention:   Device: Minimally Invasive Ponto Surgery Sponsor:   Oticon Medical Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MBQ2mn

Exploring the Use of ECochG Testing During Electrode Insertion in Cochlear Implant Surgery

Conditions:   Cochlear Implants;   Hearing Preservation Intervention:   Procedure: Electrocochlography Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sRKueg

Iron and Pollen Allergy in Women

Conditions:   Allergy Pollen;   Healthy Interventions:   Dietary Supplement: ImmunoBon;   Dietary Supplement: Placebo Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2COMUPG

What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?

Conditions:   Invasive Pneumococcal Disease, Recurrent Isolated, 1;   Invasive Pneumococcal Disease, Recurrent Isolated, 2;   Invasive Pneumococcal Disease, Protection Against;   Primary Immunodeficiency Intervention:   Other: Referral to Immunology Sponsor:   Murdoch Childrens Research Institute Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CMQTw3

A Randomized Experiment of Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: the TESTsmART Trial Aim 1

Conditions:   Malaria;   Febrile Illness Interventions:   Other: Conditional ACT subsidy, Arm 1 levels;   Other: Conditional ACT subsidy, Arm 2 levels;   Other: Conditional ACT subsidy, Arm 3 levels;   Other: Conditional ACT subsidy, Arm 4 levels Sponsors:   Duke University;   National Institute of Allergy and Infectious Diseases (NIAID);   Moi University;   Clinton Health Access Initiative, Nigeria Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CPMQiv

Iron and Pollen Allergy in Women

Conditions:   Allergy Pollen;   Healthy Interventions:   Dietary Supplement: ImmunoBon;   Dietary Supplement: Placebo Sponsor:   Medical University of Vienna Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2COMUPG

Immunogenicity and Safety Study of Inactivated Subunit H5N1 Influenza Vaccine in Prior Recipients of Live Attenuated H2N2, H6N1 and H9N2 Influenza Vaccines and in H5N1 and Live Attenuated Vaccine Na ïve Individuals

Condition:   Influenza Intervention:   Biological: H5N1 pISV Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RVO9H1

What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?

Conditions:   Invasive Pneumococcal Disease, Recurrent Isolated, 1;   Invasive Pneumococcal Disease, Recurrent Isolated, 2;   Invasive Pneumococcal Disease, Protection Against;   Primary Immunodeficiency Intervention:   Other: Referral to Immunology Sponsor:   Murdoch Childrens Research Institute Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CMQTw3

Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine, VRCFLUNPF099-00-VP, in Healthy Adults

Condition:   Influenza Interventions:   Other: VRC-PBSPLA043-00-VP (phosphate buffered saline);   Biological: VRC-FLUNPF099-00-VP (H1ssF_3928) Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RVQB0t

A Randomized Experiment of Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: the TESTsmART Trial Aim 1

Conditions:   Malaria;   Febrile Illness Interventions:   Other: Conditional ACT subsidy, Arm 1 levels;   Other: Conditional ACT subsidy, Arm 2 levels;   Other: Conditional ACT subsidy, Arm 3 levels;   Other: Conditional ACT subsidy, Arm 4 levels Sponsors:   Duke University;   National Institute of Allergy and Infectious Diseases (NIAID);   Moi University;   Clinton Health Access Initiative, Nigeria Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CPMQiv

What do we know about gambling-related harm affecting migrants and migrant communities? A rapid review

Publication date: Available online 26 January 2019

Source: Addictive Behaviors

Author(s): Heather Wardle, Stephanie Bramley, Caroline Norrie, Jill Manthorpe

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Wn0Wkr

Alcohol-related effects of POST-9/11 discrimination in the context of the great recession: Race/ethnic variation

Publication date: Available online 26 January 2019

Source: Addictive Behaviors

Author(s): Robyn Lewis Brown, Judith A. Richman, Myles D. Moody, Kathleen M. Rospenda

Abstract

Objectives

This study examined whether race/ethnic variation in discrimination is differentially associated with economic adversity during the period of the Great Recession for Blacks and Latinos compared to non-Hispanic Whites, thereby contributing to higher rates of alcohol use and problematic drinking among these groups.

Methods

Structural equation modeling was used to analyze data from a national mail survey.

Results

The association of 9/11-related discrimination with problem-related drinking substantially derives from the association between 9/11-related discrimination and recession-era economic adversity. The association between 9/11-related discrimination and economic adversity is also significantly greater for Blacks and Latinos compared to non-Hispanic Whites, and is more strongly linked with problem-related drinking for both groups in contrast to non-Hispanic Whites.

Conclusions

Overall, the results demonstrate the sustained association of 9/11-related discrimination with alcohol use for Blacks and Latinos compared to non-Hispanic Whites, as well as the differential impact of the Great Recession for these race/ethnic groups. The findings highlight the need to acknowledge macro-level stressors that disproportionately affect disadvantaged groups, such as those occasioned by discriminatory legislation and social policies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RgsnZq

What do we know about gambling-related harm affecting migrants and migrant communities? A rapid review

Publication date: Available online 26 January 2019

Source: Addictive Behaviors

Author(s): Heather Wardle, Stephanie Bramley, Caroline Norrie, Jill Manthorpe

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Wn0Wkr

Alcohol-related effects of POST-9/11 discrimination in the context of the great recession: Race/ethnic variation

Publication date: Available online 26 January 2019

Source: Addictive Behaviors

Author(s): Robyn Lewis Brown, Judith A. Richman, Myles D. Moody, Kathleen M. Rospenda

Abstract

Objectives

This study examined whether race/ethnic variation in discrimination is differentially associated with economic adversity during the period of the Great Recession for Blacks and Latinos compared to non-Hispanic Whites, thereby contributing to higher rates of alcohol use and problematic drinking among these groups.

Methods

Structural equation modeling was used to analyze data from a national mail survey.

Results

The association of 9/11-related discrimination with problem-related drinking substantially derives from the association between 9/11-related discrimination and recession-era economic adversity. The association between 9/11-related discrimination and economic adversity is also significantly greater for Blacks and Latinos compared to non-Hispanic Whites, and is more strongly linked with problem-related drinking for both groups in contrast to non-Hispanic Whites.

Conclusions

Overall, the results demonstrate the sustained association of 9/11-related discrimination with alcohol use for Blacks and Latinos compared to non-Hispanic Whites, as well as the differential impact of the Great Recession for these race/ethnic groups. The findings highlight the need to acknowledge macro-level stressors that disproportionately affect disadvantaged groups, such as those occasioned by discriminatory legislation and social policies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RgsnZq