Κυριακή 16 Δεκεμβρίου 2018

Rates of sialoendoscopy and sialoadenectomy in 5,111 adults with private insurance

Objective

To determine frequencies and trends in sialoendoscopy and sialoadenectomy for the treatment of obstructive, nonneoplastic submandibular gland disease in the United States.

Methods

Epidemiologic study of insurance claims from 2006 to 2013 in a large, private insurance claims database. Rates were calculated for patients undergoing one or both index procedures.

Results

A total of 5,111 adults with sialadenitis who underwent sialoendoscopy or submandibular gland excision were included. Mean age was 47.6 years, and patients undergoing sialoendoscopy were less likely to be male (relative risk [RR] = 0.84; 95% confidence interval [CI], 0.78–0.89), more likely to have sialoadenitis without stones (RR = 1.60; 95% CI, 1.53–1.66), and had a similar number of comorbidities (RR = 1.00; 95% CI, 0.91–1.06) compared to patients undergoing sialoadenectomy. The most common complication after sialoadenectomy was surgical site infection (1.4%; 95% CI, 1.1–1.8%), and complications after sialoendoscopy were rare. From 2007 to 2013, use of sialoendoscopy increased from 0.13 (95% CI, 0.08–0.18) to 0.42 (95% CI, 0.40–0.45) per 100 thousand people, and sialoadenectomy decreased from 2.41 (95% CI, 2.39–2.42) to 1.43 (95% CI, 1.40–1.44) per 100 thousand. The highest mean rate of sialadenectomy was seen in the south (2.15 per 100,000; 95% CI, 2.13–2.16), the lowest was in the west (1.6 per 100,000; 95% CI, 1.57–1.62), and it decreased in all regions over time.

Conclusion

Utilization of sialoendoscopy has increased over time, and the overall rate of sialoadenectomy is decreasing. Both procedures are safe for treatment of patients with sialadenitis and sialolithiasis. Future research should examine whether availability of sialoendoscopy leads to a decreased rate of sialoadenectomy in patients with salivary gland disease.

Level of Evidence

2c. Laryngoscope, 2018



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Rates of sialoendoscopy and sialoadenectomy in 5,111 adults with private insurance

Objective

To determine frequencies and trends in sialoendoscopy and sialoadenectomy for the treatment of obstructive, nonneoplastic submandibular gland disease in the United States.

Methods

Epidemiologic study of insurance claims from 2006 to 2013 in a large, private insurance claims database. Rates were calculated for patients undergoing one or both index procedures.

Results

A total of 5,111 adults with sialadenitis who underwent sialoendoscopy or submandibular gland excision were included. Mean age was 47.6 years, and patients undergoing sialoendoscopy were less likely to be male (relative risk [RR] = 0.84; 95% confidence interval [CI], 0.78–0.89), more likely to have sialoadenitis without stones (RR = 1.60; 95% CI, 1.53–1.66), and had a similar number of comorbidities (RR = 1.00; 95% CI, 0.91–1.06) compared to patients undergoing sialoadenectomy. The most common complication after sialoadenectomy was surgical site infection (1.4%; 95% CI, 1.1–1.8%), and complications after sialoendoscopy were rare. From 2007 to 2013, use of sialoendoscopy increased from 0.13 (95% CI, 0.08–0.18) to 0.42 (95% CI, 0.40–0.45) per 100 thousand people, and sialoadenectomy decreased from 2.41 (95% CI, 2.39–2.42) to 1.43 (95% CI, 1.40–1.44) per 100 thousand. The highest mean rate of sialadenectomy was seen in the south (2.15 per 100,000; 95% CI, 2.13–2.16), the lowest was in the west (1.6 per 100,000; 95% CI, 1.57–1.62), and it decreased in all regions over time.

Conclusion

Utilization of sialoendoscopy has increased over time, and the overall rate of sialoadenectomy is decreasing. Both procedures are safe for treatment of patients with sialadenitis and sialolithiasis. Future research should examine whether availability of sialoendoscopy leads to a decreased rate of sialoadenectomy in patients with salivary gland disease.

Level of Evidence

2c. Laryngoscope, 2018



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The unexpected growth in Head and Neck Cancer Treatment Market Report 2018 has remarkable insights and positive outlook towards 2023 - Coherent Chronicle

The unexpected growth in Head and Neck Cancer Treatment Market Report 2018 has remarkable insights and positive outlook towards 2023  Coherent Chronicle

According to the new market research report on "Global Head and Neck Cancer Treatment Market Report 2018 – 2023" covers there Product Type, Region ...



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Teenager who met Meghan Markle and Prince Harry in New Zealand dies of cancer - Mirror Online

Teenager who met Meghan Markle and Prince Harry in New Zealand dies of cancer  Mirror Online

Eva McGauley, 18, inspired thousands when she set up women's rights charity Eva's Wish during her three-year fight against a rare type of head and neck ...



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The unexpected growth in Head and Neck Cancer Treatment Market Report 2018 has remarkable insights and positive outlook towards 2023 - Coherent Chronicle

The unexpected growth in Head and Neck Cancer Treatment Market Report 2018 has remarkable insights and positive outlook towards 2023  Coherent Chronicle

According to the new market research report on "Global Head and Neck Cancer Treatment Market Report 2018 – 2023" covers there Product Type, Region ...



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Teenager who met Meghan Markle and Prince Harry in New Zealand dies of cancer - Mirror Online

Teenager who met Meghan Markle and Prince Harry in New Zealand dies of cancer  Mirror Online

Eva McGauley, 18, inspired thousands when she set up women's rights charity Eva's Wish during her three-year fight against a rare type of head and neck ...



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Huawei exec details health problems in affidavit submitted to B.C. court - Drayton Valley Western Review

China-Huawei-Cda-20181212-1.jpg?quality=

Huawei exec details health problems in affidavit submitted to B.C. court  Drayton Valley Western Review

I continue to feel unwell and I am worried about my health deteriorating while I am incarcerated," Meng Wanzhou says of her time at the Alouette Correctional ...



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Huawei exec details health problems in affidavit submitted to B.C. court - Drayton Valley Western Review

China-Huawei-Cda-20181212-1.jpg?quality=

Huawei exec details health problems in affidavit submitted to B.C. court  Drayton Valley Western Review

I continue to feel unwell and I am worried about my health deteriorating while I am incarcerated," Meng Wanzhou says of her time at the Alouette Correctional ...



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Increased perfusion in dynamic gadolinium‐enhanced MRI correlates with areas of bone repair and of bone necrosis in patients with Kienböck's disease

Background

Osteonecrosis of the lunate, Kienböck's disease, can lead to fragmentation of the lunate, carpal collapse, and severe osteoarthritis. Since the etiology of Kienböck's disease is impaired circulation, a diagnostic method capable of assessing perfusion would be valuable. Recent studies have suggested that dynamic contrast‐enhanced (DCE) MR examinations at 3 T can assess perfusion in healthy carpal bones.

Purpose

To evaluate the use of DCE‐MR for assessing perfusion in the lunate bone in patients with Kienböck's disease. Furthermore, to compare perfusion with histopathology with a focus on bone viability.

Study Type

Prospective case–control study.

Population

Fourteen patients with Kienböck's disease and a control group of 19 healthy subjects.

Field Strength: 3 T with T1‐weighted fat‐saturated contrast‐enhanced gradient echo series.

Assessment

Features of the enhancement curves from the DCE‐MR examinations, time to peak (TTP), maximum slope (MS), and maximum enhancement (ME) assessed by a radiologist. Six of 14 patients were surgerized with lunate excision, allowing comparison between features of the enhancement curves and histopathology.

Statistical Tests

Mann–Whitney U‐test. P < 0.05 was considered a statistically significant difference.

Results

Patients with Kienböck's disease showed significantly higher and faster perfusion parameters compared with the control group, the mean value of the TTP in patients was 126.73 sec, in controls 189.79 sec (P = 0.024), ME in patients 173.55 AU, in controls 28.46 AU (P < 0.001), and MS in patients 5.04 AU, in controls 1.06 AU (P < 0.001). When compared with histopathology, increased perfusion was seen in areas of bone formation but also in necrosis. Areas of normal bone showed low perfusion.

Data Conclusion

DCE‐MRI at 3 T can diagnose altered perfusion in patients with Kienböck's disease. Increased perfusion cannot definitely be used as a marker of bone viability.

Level of Evidence: 1

Technical Efficacy: Stage 3

J. Magn. Reson. Imaging 2018.



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Increased perfusion in dynamic gadolinium‐enhanced MRI correlates with areas of bone repair and of bone necrosis in patients with Kienböck's disease

Background

Osteonecrosis of the lunate, Kienböck's disease, can lead to fragmentation of the lunate, carpal collapse, and severe osteoarthritis. Since the etiology of Kienböck's disease is impaired circulation, a diagnostic method capable of assessing perfusion would be valuable. Recent studies have suggested that dynamic contrast‐enhanced (DCE) MR examinations at 3 T can assess perfusion in healthy carpal bones.

Purpose

To evaluate the use of DCE‐MR for assessing perfusion in the lunate bone in patients with Kienböck's disease. Furthermore, to compare perfusion with histopathology with a focus on bone viability.

Study Type

Prospective case–control study.

Population

Fourteen patients with Kienböck's disease and a control group of 19 healthy subjects.

Field Strength: 3 T with T1‐weighted fat‐saturated contrast‐enhanced gradient echo series.

Assessment

Features of the enhancement curves from the DCE‐MR examinations, time to peak (TTP), maximum slope (MS), and maximum enhancement (ME) assessed by a radiologist. Six of 14 patients were surgerized with lunate excision, allowing comparison between features of the enhancement curves and histopathology.

Statistical Tests

Mann–Whitney U‐test. P < 0.05 was considered a statistically significant difference.

Results

Patients with Kienböck's disease showed significantly higher and faster perfusion parameters compared with the control group, the mean value of the TTP in patients was 126.73 sec, in controls 189.79 sec (P = 0.024), ME in patients 173.55 AU, in controls 28.46 AU (P < 0.001), and MS in patients 5.04 AU, in controls 1.06 AU (P < 0.001). When compared with histopathology, increased perfusion was seen in areas of bone formation but also in necrosis. Areas of normal bone showed low perfusion.

Data Conclusion

DCE‐MRI at 3 T can diagnose altered perfusion in patients with Kienböck's disease. Increased perfusion cannot definitely be used as a marker of bone viability.

Level of Evidence: 1

Technical Efficacy: Stage 3

J. Magn. Reson. Imaging 2018.



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Survivors of childhood Hodgkin lymphoma face high long-term risk of solid cancers - Medical Xpress

Survivors of childhood Hodgkin lymphoma face high long-term risk of solid cancers  Medical Xpress

New research refines existing evidence that survivors of childhood Hodgkin lymphoma face an elevated risk of developing various types of solid tumors many ...



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Luke Lewis says culture not punishment to cure behaviour - ESPN

r477678_400x600_2-3.jpg

Luke Lewis says culture not punishment to cure behaviour  ESPN

Retired rugby league star Luke Lewis doesn't know the answer to the recent spate of violence against women headlines, but notes that Melbourne players never ...



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Raytown High sophomore surprised at school with news she’s cancer free - WDAF FOX4 Kansas City

Raytown High sophomore surprised at school with news she's cancer free  WDAF FOX4 Kansas City

RAYTOWN, Mo. -- A local teen is extra thankful this year after she got a big surprise last week. Fifteen-year-old Emily Sadler was diagnosed with thyroid cancer ...



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Pancreatic Enzyme Supplementation in Patients with Atopic Dermatitis and Food Allergies: An Open-Label Pilot Study

ConclusionsPancreatic enzyme supplementation was associated with improved AD and gastroduodenal permeability. Additional randomized placebo-controlled studies are required before this treatment can be recommended in this clinical setting. (Source: Pediatric Drugs)

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Luke Lewis says culture not punishment to cure behaviour - ESPN

r477678_400x600_2-3.jpg

Luke Lewis says culture not punishment to cure behaviour  ESPN

Retired rugby league star Luke Lewis doesn't know the answer to the recent spate of violence against women headlines, but notes that Melbourne players never ...



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Survivors of childhood Hodgkin lymphoma face high long-term risk of solid cancers - Medical Xpress

Survivors of childhood Hodgkin lymphoma face high long-term risk of solid cancers  Medical Xpress

New research refines existing evidence that survivors of childhood Hodgkin lymphoma face an elevated risk of developing various types of solid tumors many ...



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Raytown High sophomore surprised at school with news she’s cancer free - WDAF FOX4 Kansas City

Raytown High sophomore surprised at school with news she's cancer free  WDAF FOX4 Kansas City

RAYTOWN, Mo. -- A local teen is extra thankful this year after she got a big surprise last week. Fifteen-year-old Emily Sadler was diagnosed with thyroid cancer ...



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Pancreatic Enzyme Supplementation in Patients with Atopic Dermatitis and Food Allergies: An Open-Label Pilot Study

ConclusionsPancreatic enzyme supplementation was associated with improved AD and gastroduodenal permeability. Additional randomized placebo-controlled studies are required before this treatment can be recommended in this clinical setting. (Source: Pediatric Drugs)

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Incidental findings on 18-FDG PET–CT in head and neck cancer | European Archives of Oto-Rhino-Laryngology - MD Linx

Incidental findings on 18-FDG PET–CT in head and neck cancer | European Archives of Oto-Rhino-Laryngology  MD Linx

In patients with head and neck cancer undergoing staging or surveillance of disease, experts evaluated the rate of 'incidental' findings resulting from 18-FDG ...



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AstraZeneca's Imfinzi Flunks Late-Stage Head and Neck Cancer Trial - BioSpace

6f2a73c2-75ee-496c-ab62-98d42719dcb0

AstraZeneca's Imfinzi Flunks Late-Stage Head and Neck Cancer Trial  BioSpace

AstraZeneca and its MedImmune division announced results from its Phase III EAGLE clinical trial. Imfinzi, in combination with tremelimumab, an anti-CTLA4 ...



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Incidental findings on 18-FDG PET–CT in head and neck cancer | European Archives of Oto-Rhino-Laryngology - MD Linx

Incidental findings on 18-FDG PET–CT in head and neck cancer | European Archives of Oto-Rhino-Laryngology  MD Linx

In patients with head and neck cancer undergoing staging or surveillance of disease, experts evaluated the rate of 'incidental' findings resulting from 18-FDG ...



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AstraZeneca's Imfinzi Flunks Late-Stage Head and Neck Cancer Trial - BioSpace

6f2a73c2-75ee-496c-ab62-98d42719dcb0

AstraZeneca's Imfinzi Flunks Late-Stage Head and Neck Cancer Trial  BioSpace

AstraZeneca and its MedImmune division announced results from its Phase III EAGLE clinical trial. Imfinzi, in combination with tremelimumab, an anti-CTLA4 ...



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Outcome of patients following neo-adjuvant chemotherapy for unresectable cervical nodes in head and neck squamous cell carcinomas

Abstract

Background

This study was undertaken to assess the effects of neo-adjuvant chemotherapy (NACT) on patients with head and neck squamous cell carcinoma (HNSCC) having advanced unresectable cervical nodal metastasis.

Methodology

A retrospective cohort study was conducted to assess the response of unresectable nodes to NACT in a pragmatic manner. Patients were grouped according to the response noted and the treatment offered after chemotherapy. The median survival amongst the patients in these groups was compared.

Results

The study included 51 patients. Oral cavity was the commonest site (67.2%). Favourable nodal response was seen in 64.7% of the patients. Up to 87.9% of the nodal responders were amenable to curative intent therapy. The overall survival of patients undergoing surgery, definitive chemoradiotherapy, palliative chemotherapy and palliative radiotherapy was 24, 13, 10 and 9 months, respectively.

Conclusion

NACT may be utilized in HNSCC with advanced inoperable nodal disease to make them amenable to definitive therapy.



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Survivors of childhood Hodgkin lymphoma face high long-term risk of solid cancers - Medical Xpress

Survivors of childhood Hodgkin lymphoma face high long-term risk of solid cancers  Medical Xpress

New research refines existing evidence that survivors of childhood Hodgkin lymphoma face an elevated risk of developing various types of solid tumors many ...



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Check your medical records for dangerous errors - PhillyVoice.com

Check your medical records for dangerous errors  PhillyVoice.com

In the worst-case scenario, an incorrect diagnosis, scan or lab result may have been inserted into a record, raising the possibility of inappropriate medical ...



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Outcome of patients following neo-adjuvant chemotherapy for unresectable cervical nodes in head and neck squamous cell carcinomas

Abstract

Background

This study was undertaken to assess the effects of neo-adjuvant chemotherapy (NACT) on patients with head and neck squamous cell carcinoma (HNSCC) having advanced unresectable cervical nodal metastasis.

Methodology

A retrospective cohort study was conducted to assess the response of unresectable nodes to NACT in a pragmatic manner. Patients were grouped according to the response noted and the treatment offered after chemotherapy. The median survival amongst the patients in these groups was compared.

Results

The study included 51 patients. Oral cavity was the commonest site (67.2%). Favourable nodal response was seen in 64.7% of the patients. Up to 87.9% of the nodal responders were amenable to curative intent therapy. The overall survival of patients undergoing surgery, definitive chemoradiotherapy, palliative chemotherapy and palliative radiotherapy was 24, 13, 10 and 9 months, respectively.

Conclusion

NACT may be utilized in HNSCC with advanced inoperable nodal disease to make them amenable to definitive therapy.



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Survivors of childhood Hodgkin lymphoma face high long-term risk of solid cancers - Medical Xpress

Survivors of childhood Hodgkin lymphoma face high long-term risk of solid cancers  Medical Xpress

New research refines existing evidence that survivors of childhood Hodgkin lymphoma face an elevated risk of developing various types of solid tumors many ...



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Check your medical records for dangerous errors - PhillyVoice.com

Check your medical records for dangerous errors  PhillyVoice.com

In the worst-case scenario, an incorrect diagnosis, scan or lab result may have been inserted into a record, raising the possibility of inappropriate medical ...



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Tosk Announces Clinical Study Results for TK-90 to Prevent Mucositis - EIN News

Tosk Announces Clinical Study Results for TK-90 to Prevent Mucositis  EIN News

Tosk drug TK-90 successful in preventing painful, dose-limiting mucositis caused by common cancer therapies.



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Tosk Announces Clinical Study Results for TK-90 to Prevent Mucositis - EIN News

Tosk Announces Clinical Study Results for TK-90 to Prevent Mucositis  EIN News

Tosk drug TK-90 successful in preventing painful, dose-limiting mucositis caused by common cancer therapies.



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Initial experience with image‐guided surgical navigation in transoral surgery

Abstract

Background

Surgical navigation using image guidance may improve the safety and efficacy of transoral surgery (TOS); however, preoperative imaging cannot be accurately registered to the intraoperative state due to deformations resulting from placement of the laryngoscope or retractor. This proof of concept study explores feasibility and registration accuracy of surgical navigation for TOS by utilizing intraoperative imaging.

Methods

Four patients undergoing TOS were recruited. Suspension laryngoscopy was performed with a CT‐compatible laryngoscope. An intraoperative contrast enhanced CT scan was obtained and registered to fiducials placed on the neck, face, and laryngoscope.

Results

All patients were successfully scanned and registered. Registration accuracy within the pharynx and larynx was 1 mm or less. Target registration was confirmed by localizing endoscopic and surface structures to the CT images. Successful tracking was performed in all 4 patients.

Conclusion

For surgical navigation during TOS, although a high level of registration accuracy can be achieved by utilizing intraoperative imaging, significant limitations of the existing technology have been identified. These limitations, as well as areas for future investigation, are discussed.



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PI3‐kinase pathway biomarkers in oral cancer and tumor immune cells

Abstract

Background

This study investigated the hypothesis that phosphoinositide 3‐kinase (PI3‐kinase) pathway dysregulation in either head and neck cancer cells and/or tumor infiltrating immune cells would influence outcomes of patients with surgically treated oral tongue squamous cell carcinomas (SCC).

Methods

We constructed tissue microarrays containing 123 oral tongue SCC samples and performed immunohistochemistry using antibodies against 7 PI3‐kinase pathway markers: phosphatase and tensin homolog (PTEN), Akt, p‐Akt, mammalian target of rapamycin (mTOR), phosphorylated‐mammalian target of rapamycin (p‐mTOR), survivin, and Ki‐67). Expression levels in cancer cells or tumor infiltrating immune cells were correlated with outcomes.

Results

Higher levels of PTEN expression in immune cells were significantly associated with improved recurrence‐free survival (heart rate (HR) = 0.45, 95% confidence interval (CI) 0.23‐0.90, P = .03), and overall survival (HR = 0.34, 95% CI 0.15‐0.76, P = .01) on univariate and multicovariate models.

Conclusions

We identified a novel, negative prognostic role of PI3‐kinase activation (as determined by PTEN loss) in oral SCC infiltrating immune cells. These findings could be relevant for clinical development of PI‐3 kinase inhibitors for this disease.



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Initial experience with image‐guided surgical navigation in transoral surgery

Abstract

Background

Surgical navigation using image guidance may improve the safety and efficacy of transoral surgery (TOS); however, preoperative imaging cannot be accurately registered to the intraoperative state due to deformations resulting from placement of the laryngoscope or retractor. This proof of concept study explores feasibility and registration accuracy of surgical navigation for TOS by utilizing intraoperative imaging.

Methods

Four patients undergoing TOS were recruited. Suspension laryngoscopy was performed with a CT‐compatible laryngoscope. An intraoperative contrast enhanced CT scan was obtained and registered to fiducials placed on the neck, face, and laryngoscope.

Results

All patients were successfully scanned and registered. Registration accuracy within the pharynx and larynx was 1 mm or less. Target registration was confirmed by localizing endoscopic and surface structures to the CT images. Successful tracking was performed in all 4 patients.

Conclusion

For surgical navigation during TOS, although a high level of registration accuracy can be achieved by utilizing intraoperative imaging, significant limitations of the existing technology have been identified. These limitations, as well as areas for future investigation, are discussed.



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PI3‐kinase pathway biomarkers in oral cancer and tumor immune cells

Abstract

Background

This study investigated the hypothesis that phosphoinositide 3‐kinase (PI3‐kinase) pathway dysregulation in either head and neck cancer cells and/or tumor infiltrating immune cells would influence outcomes of patients with surgically treated oral tongue squamous cell carcinomas (SCC).

Methods

We constructed tissue microarrays containing 123 oral tongue SCC samples and performed immunohistochemistry using antibodies against 7 PI3‐kinase pathway markers: phosphatase and tensin homolog (PTEN), Akt, p‐Akt, mammalian target of rapamycin (mTOR), phosphorylated‐mammalian target of rapamycin (p‐mTOR), survivin, and Ki‐67). Expression levels in cancer cells or tumor infiltrating immune cells were correlated with outcomes.

Results

Higher levels of PTEN expression in immune cells were significantly associated with improved recurrence‐free survival (heart rate (HR) = 0.45, 95% confidence interval (CI) 0.23‐0.90, P = .03), and overall survival (HR = 0.34, 95% CI 0.15‐0.76, P = .01) on univariate and multicovariate models.

Conclusions

We identified a novel, negative prognostic role of PI3‐kinase activation (as determined by PTEN loss) in oral SCC infiltrating immune cells. These findings could be relevant for clinical development of PI‐3 kinase inhibitors for this disease.



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Press Announcements - FDA.gov

Press Announcements  FDA.gov

The FDA granted accelerated approval to Vitrakvi (larotrectinib), a treatment for adult and pediatric patients whose cancers have a specific genetic feature ...



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Press Announcements - FDA.gov

Press Announcements  FDA.gov

The FDA granted accelerated approval to Vitrakvi (larotrectinib), a treatment for adult and pediatric patients whose cancers have a specific genetic feature ...



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Salt Accumulation May Be a Factor in Atopic Dermatitis

(MedPage Today) -- But hypothesis regarding sodium chloride levels in skin needs more work, expert says (Source: MedPage Today Allergy)

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Salt Accumulation May Be a Factor in Atopic Dermatitis

(MedPage Today) -- But hypothesis regarding sodium chloride levels in skin needs more work, expert says (Source: MedPage Today Allergy)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



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Interpace Diagnostics Group Inc (IDXG) Receives Average Rating of “Buy” from Analysts - Fairfield Current

pdi-logo.jpg

Interpace Diagnostics Group Inc (IDXG) Receives Average Rating of "Buy" from Analysts  Fairfield Current

Shares of Interpace Diagnostics Group Inc (NASDAQ:IDXG) have been assigned an average rating of "Buy" from the seven ratings firms that are currently ...



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Excess weight responsible for cancers globally finds report - News-Medical.net

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Excess weight responsible for cancers globally finds report  News-Medical.net

According to a new report published this week, excess body weight is one of the major reasons behind cancers worldwide. The report written by scientists at the ...



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Get Pink: OU professor defies odds despite breast-cancer diagnosis - KOKH FOX25

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Get Pink: OU professor defies odds despite breast-cancer diagnosis  KOKH FOX25

Melissa Medina didn't just win the Susan G. Koman survivors' race at Race For the Cure this year — she's finished first for four consecutive years. A positive ...



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Global Head and Neck Cancer Diagnostics Market 2018 Outline | New Developments with Operational Updates in Industry Forecast 2025 - Techno Biz News

Global Head and Neck Cancer Diagnostics Market 2018 Outline | New Developments with Operational Updates in Industry Forecast 2025  Techno Biz News

Global Head and Neck Cancer Diagnostics Market, with respect to the regional spectrum, has been split into United States, Europe, China, Japan & Other ...



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Interpace Diagnostics Group Inc (IDXG) Receives Average Rating of “Buy” from Analysts - Fairfield Current

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Interpace Diagnostics Group Inc (IDXG) Receives Average Rating of "Buy" from Analysts  Fairfield Current

Shares of Interpace Diagnostics Group Inc (NASDAQ:IDXG) have been assigned an average rating of "Buy" from the seven ratings firms that are currently ...



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Excess weight responsible for cancers globally finds report - News-Medical.net

image.axd?picture=2018%2F12%2Fshuttersto

Excess weight responsible for cancers globally finds report  News-Medical.net

According to a new report published this week, excess body weight is one of the major reasons behind cancers worldwide. The report written by scientists at the ...



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Get Pink: OU professor defies odds despite breast-cancer diagnosis - KOKH FOX25

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Get Pink: OU professor defies odds despite breast-cancer diagnosis  KOKH FOX25

Melissa Medina didn't just win the Susan G. Koman survivors' race at Race For the Cure this year — she's finished first for four consecutive years. A positive ...



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Global Head and Neck Cancer Diagnostics Market 2018 Outline | New Developments with Operational Updates in Industry Forecast 2025 - Techno Biz News

Global Head and Neck Cancer Diagnostics Market 2018 Outline | New Developments with Operational Updates in Industry Forecast 2025  Techno Biz News

Global Head and Neck Cancer Diagnostics Market, with respect to the regional spectrum, has been split into United States, Europe, China, Japan & Other ...



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Excess weight responsible for cancers globally finds report - News-Medical.net

image.axd?picture=2018%2F12%2Fshuttersto

Excess weight responsible for cancers globally finds report  News-Medical.net

According to a new report published this week, excess body weight is one of the major reasons behind cancers worldwide. The report written by scientists at the ...



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Salt Accumulation May Be a Factor in Atopic Dermatitis

(MedPage Today) -- But hypothesis regarding sodium chloride levels in skin needs more work, expert says (Source: MedPage Today Allergy)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



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Excess weight responsible for cancers globally finds report - News-Medical.net

image.axd?picture=2018%2F12%2Fshuttersto

Excess weight responsible for cancers globally finds report  News-Medical.net

According to a new report published this week, excess body weight is one of the major reasons behind cancers worldwide. The report written by scientists at the ...



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Salt Accumulation May Be a Factor in Atopic Dermatitis

(MedPage Today) -- But hypothesis regarding sodium chloride levels in skin needs more work, expert says (Source: MedPage Today Allergy)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



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Inside Huawei CFO Meng Wanzhou's Crazy Rich life in Canada - The Independent

Screen-Shot-2018-12-12-at-11.34.29-AM-69

Inside Huawei CFO Meng Wanzhou's Crazy Rich life in Canada  The Independent

Meng Wanzhou made international headlines when she was arrested in Canada on December 1. The Chief Finance Officer (CFO) of China's largest private ...



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Inside Huawei CFO Meng Wanzhou's Crazy Rich life in Canada - The Independent

Screen-Shot-2018-12-12-at-11.34.29-AM-69

Inside Huawei CFO Meng Wanzhou's Crazy Rich life in Canada  The Independent

Meng Wanzhou made international headlines when she was arrested in Canada on December 1. The Chief Finance Officer (CFO) of China's largest private ...



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New cancer drug: Promising treatment saves 9-year-old boy with stage 4 thyroid cancer - KGO-TV

New cancer drug: Promising treatment saves 9-year-old boy with stage 4 thyroid cancer  KGO-TV

The FDA just approved a breakthrough drug that could help thousands of cancer patients every year. It's already giving hope to a family who thought they were ...



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FDA approves ‘precision medicine’ drug for different cancers with same mutation - Washington Post

FDA approves 'precision medicine' drug for different cancers with same mutation  Washington Post

The Food and Drug Administration on Monday approved a drug for a wide range of cancers based on a shared mutation, rather than the tumors' locations — an ...



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New cancer drug: Promising treatment saves 9-year-old boy with stage 4 thyroid cancer - KGO-TV

New cancer drug: Promising treatment saves 9-year-old boy with stage 4 thyroid cancer  KGO-TV

The FDA just approved a breakthrough drug that could help thousands of cancer patients every year. It's already giving hope to a family who thought they were ...



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FDA approves ‘precision medicine’ drug for different cancers with same mutation - Washington Post

FDA approves 'precision medicine' drug for different cancers with same mutation  Washington Post

The Food and Drug Administration on Monday approved a drug for a wide range of cancers based on a shared mutation, rather than the tumors' locations — an ...



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Holiday season increases heart attack risk, Swedish study says - UPI News

healthday.jpg

Holiday season increases heart attack risk, Swedish study says  UPI News

Whether it's the stress of choosing the right gift, drinking and eating too much, or fighting with relatives about politics, the holidays can be hard on your heart.



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Holiday season increases heart attack risk, Swedish study says - UPI News

healthday.jpg

Holiday season increases heart attack risk, Swedish study says  UPI News

Whether it's the stress of choosing the right gift, drinking and eating too much, or fighting with relatives about politics, the holidays can be hard on your heart.



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Huawei exec details health problems in affidavit submitted to B.C. court - The Province

China-Huawei-Cda-20181212-1.jpg?quality=

Huawei exec details health problems in affidavit submitted to B.C. court  The Province

I continue to feel unwell and I am worried about my health deteriorating while I am incarcerated," Meng Wanzhou says of her time at the Alouette Correctional ...



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Huawei exec details health problems in affidavit submitted to B.C. court - The Province

China-Huawei-Cda-20181212-1.jpg?quality=

Huawei exec details health problems in affidavit submitted to B.C. court  The Province

I continue to feel unwell and I am worried about my health deteriorating while I am incarcerated," Meng Wanzhou says of her time at the Alouette Correctional ...



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Effects of isoquinoline alkaloids from Macleaya cordata on physiological, immunological and inflammatory parameters in healthy beagles

In conclusion, the addition of IQs in the given dose was well tolerated and did not have adverse effects in healthy dogs. (Source: Journal of Animal Physiology and Animal Nutrition)

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Effects of isoquinoline alkaloids from Macleaya cordata on physiological, immunological and inflammatory parameters in healthy beagles

In conclusion, the addition of IQs in the given dose was well tolerated and did not have adverse effects in healthy dogs. (Source: Journal of Animal Physiology and Animal Nutrition)

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Subcutaneous expanders and synthetic mesh for breast reconstruction: long-term and patient reported BREAST-Q outcomes of a single center prospective study

Recently, prepectoral breast reconstruction is experiencing a revival. Despite of the growing body of early reports about subcutaneous breast reconstruction, literature lacks of long term results and studies focusing on patient-reported outcomes and heath related quality of life (HRQOL).Between January 2012 and December 2016, patients undergoing mastectomy were enrolled at our Institution. We selected patients diagnosed for breast cancer or genetic predisposition to breast cancer, undergoing conservative mastectomy, either nipple-sparing (NSM) or skin-sparing mastectomy (SSM), willing for prepectoral tissue expander reconstruction assisted by a synthetic mesh.

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Evolving role of Surgeons with the use of implant based breast reconstruction

We read with great interest the article written by Poole et al1 and it was interesting to note the outcome of implant-based breast reconstructive surgery particularly with time. It appears that cosmetic dissatisfaction, pain and capsular contracture were the main contributing factors. Their complication rates compare favourably with the National mastectomy and the Implant based breast reconstruction (IBRA) audit findings.

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The Influence of Social Media on Women Undergoing Immediate Breast Reconstruction

With nearly four-fifths of the United States population utilizing social media, these networks are quickly becoming a tool for physicians to disseminate and patients to find information.1 While it is likely that social media is one of the sources through which breast reconstruction patients seek and obtain information, this has never been assessed. The goal of this study was to determine which, if any, social media sources were influencing women's choice in breast reconstruction and which were the most influential sources of information.

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Subcutaneous expanders and synthetic mesh for breast reconstruction: long-term and patient reported BREAST-Q outcomes of a single center prospective study

Recently, prepectoral breast reconstruction is experiencing a revival. Despite of the growing body of early reports about subcutaneous breast reconstruction, literature lacks of long term results and studies focusing on patient-reported outcomes and heath related quality of life (HRQOL).Between January 2012 and December 2016, patients undergoing mastectomy were enrolled at our Institution. We selected patients diagnosed for breast cancer or genetic predisposition to breast cancer, undergoing conservative mastectomy, either nipple-sparing (NSM) or skin-sparing mastectomy (SSM), willing for prepectoral tissue expander reconstruction assisted by a synthetic mesh.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CivxaZ

Evolving role of Surgeons with the use of implant based breast reconstruction

We read with great interest the article written by Poole et al1 and it was interesting to note the outcome of implant-based breast reconstructive surgery particularly with time. It appears that cosmetic dissatisfaction, pain and capsular contracture were the main contributing factors. Their complication rates compare favourably with the National mastectomy and the Implant based breast reconstruction (IBRA) audit findings.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SPxi4M

The Influence of Social Media on Women Undergoing Immediate Breast Reconstruction

With nearly four-fifths of the United States population utilizing social media, these networks are quickly becoming a tool for physicians to disseminate and patients to find information.1 While it is likely that social media is one of the sources through which breast reconstruction patients seek and obtain information, this has never been assessed. The goal of this study was to determine which, if any, social media sources were influencing women's choice in breast reconstruction and which were the most influential sources of information.

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AstraZeneca looks to salvage data from negative Imfinzi lung cancer study - MedCity News

AstraZeneca looks to salvage data from negative Imfinzi lung cancer study  MedCity News

British drugmaker AstraZeneca is doing a deep dive into data from an immunotherapy study in lung cancer whose negative results were announced last month ...



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AstraZeneca looks to salvage data from negative Imfinzi lung cancer study - MedCity News

AstraZeneca looks to salvage data from negative Imfinzi lung cancer study  MedCity News

British drugmaker AstraZeneca is doing a deep dive into data from an immunotherapy study in lung cancer whose negative results were announced last month ...



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Current opinion and perspectives on the methods for tracking and monitoring plant growth‒promoting bacteria

Publication date: Available online 15 December 2018Source: Soil Biology and BiochemistryAuthor(s): J.I. Rilling, J.A. Acuña, P. Nannipieri, F. Cassan, F. Maruyama, M.A. JorqueraAbstractSince the 1980s, plant growth‒promoting bacteria (PGPB) have been studied as a sustainable alternative to the use of chemical fertilizers to increase crop yields, and effective PGPB have been isolated from diverse plant (e.g., endosphere and phyllosphere) and soil (e.g., rhizosphere) compartments. Despite the promising plant growth promotion results commonly observed under laboratory and greenhouse conditions, the successful application of PGPB under field conditions has been limited, partly by the lack of knowledge of the ecological/environmental factors affecting the colonization, prevalence and activit...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



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Microbial patterns in patients with histamine intolerance.

Authors: Schink M, Konturek PC, Tietz E, Dieterich W, Pinzer TC, Wirtz S, Neurath MF, Zopf Y Abstract Histamine intolerance represents a controversially discussed disorder. Besides an impaired degradation of orally supplied histamine due to diamine oxidase (DAO) deficiency, a deranged gut flora may also contribute to elevated histamine levels. Our aim was to determine the intestinal bacterial composition in patients with proven histamine intolerance in comparison to other food intolerances and healthy controls. A total of 64 participants were included in the study, encompassing 8 patients with histamine intolerance (HIT), 25 with food hypersensitivity (FH), 21 with food allergy and 10 healthy controls (HC). All participants underwent blood testing for total and food-specific immuno...

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Tissue Factor overexpression in platelets of patients with Antiphospholipid Syndrome: induction role of anti- β2-GPI antibodies.

This article is protected by copyright. All rights reserved. PMID: 30549270 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)

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Current opinion and perspectives on the methods for tracking and monitoring plant growth‒promoting bacteria

Publication date: Available online 15 December 2018Source: Soil Biology and BiochemistryAuthor(s): J.I. Rilling, J.A. Acuña, P. Nannipieri, F. Cassan, F. Maruyama, M.A. JorqueraAbstractSince the 1980s, plant growth‒promoting bacteria (PGPB) have been studied as a sustainable alternative to the use of chemical fertilizers to increase crop yields, and effective PGPB have been isolated from diverse plant (e.g., endosphere and phyllosphere) and soil (e.g., rhizosphere) compartments. Despite the promising plant growth promotion results commonly observed under laboratory and greenhouse conditions, the successful application of PGPB under field conditions has been limited, partly by the lack of knowledge of the ecological/environmental factors affecting the colonization, prevalence and activit...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QDIzsb

Microbial patterns in patients with histamine intolerance.

Authors: Schink M, Konturek PC, Tietz E, Dieterich W, Pinzer TC, Wirtz S, Neurath MF, Zopf Y Abstract Histamine intolerance represents a controversially discussed disorder. Besides an impaired degradation of orally supplied histamine due to diamine oxidase (DAO) deficiency, a deranged gut flora may also contribute to elevated histamine levels. Our aim was to determine the intestinal bacterial composition in patients with proven histamine intolerance in comparison to other food intolerances and healthy controls. A total of 64 participants were included in the study, encompassing 8 patients with histamine intolerance (HIT), 25 with food hypersensitivity (FH), 21 with food allergy and 10 healthy controls (HC). All participants underwent blood testing for total and food-specific immuno...

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Tissue Factor overexpression in platelets of patients with Antiphospholipid Syndrome: induction role of anti- β2-GPI antibodies.

This article is protected by copyright. All rights reserved. PMID: 30549270 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)

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Cooper University Health Care to Establish New ENT Residency Program - South Jersey Observer

Cooper University Health Care to Establish New ENT Residency Program  South Jersey Observer

Cooper University Health Care recently announced that it has received approval to establish an Otolaryngology-Head & Neck Surgery (ENT) residency program ...



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Cooper University Health Care to Establish New ENT Residency Program - South Jersey Observer

Cooper University Health Care to Establish New ENT Residency Program  South Jersey Observer

Cooper University Health Care recently announced that it has received approval to establish an Otolaryngology-Head & Neck Surgery (ENT) residency program ...



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Excess body weight responsible for nearly four percent of cancers worldwide - Medical Xpress

Excess body weight responsible for nearly four percent of cancers worldwide  Medical Xpress

Policies, economic systems, and marketing practices that promote the consumption of energy-dense, nutrient-poor food, changing behavioral patterns that ...



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Excess body weight responsible for nearly four percent of cancers worldwide - Medical Xpress

Excess body weight responsible for nearly four percent of cancers worldwide  Medical Xpress

Policies, economic systems, and marketing practices that promote the consumption of energy-dense, nutrient-poor food, changing behavioral patterns that ...



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Don't Let Holiday Season Stress Worsen Your Allergies, Asthma

SUNDAY, Dec. 16, 2018 -- Reducing stress could cut your risk of allergy and asthma symptoms during the holidays. " Studies show stress can cause a number of negative health effects, including causing more symptoms for allergy and asthma sufferers, " ... (Source: Drugs.com - Daily MedNews)

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Here are some of the best remedies for your seasonal allergies

(Natural News) Spring is a season of new beginnings, not just for flowering plants and trees, but also for seasonal allergies. No matter how much some people might want to enjoy the beauty that comes with the season, they just can't because they're already preoccupied with sneezing and wiping their runny noses and watery eyes. Although there are... (Source: NaturalNews.com)

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Here are some of the best remedies for your seasonal allergies

(Natural News) Spring is a season of new beginnings, not just for flowering plants and trees, but also for seasonal allergies. No matter how much some people might want to enjoy the beauty that comes with the season, they just can't because they're already preoccupied with sneezing and wiping their runny noses and watery eyes. Although there are... (Source: NaturalNews.com)

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Don't Let Holiday Season Stress Worsen Your Allergies, Asthma

SUNDAY, Dec. 16, 2018 -- Reducing stress could cut your risk of allergy and asthma symptoms during the holidays. " Studies show stress can cause a number of negative health effects, including causing more symptoms for allergy and asthma sufferers, " ... (Source: Drugs.com - Daily MedNews)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



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Silent Cancer Therapeutics Market Forecast - Industry Value, Market Size, Top Companies and General Trends for 2018-2025 - TokensTree

Silent-Cancer-Therapeutics-194328.jpg

Silent Cancer Therapeutics Market Forecast - Industry Value, Market Size, Top Companies and General Trends for 2018-2025  TokensTree

Global Silent Cancer Therapeutics Market report describes elements such as dominating companies, types, applications, classification, size, SWOT analysis, ...



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Global Head and Neck Cancer Treatment Market: Global Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2025 - DailyHover

Global Head and Neck Cancer Treatment Market: Global Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2025  DailyHover

Market.Biz Presents Global Head and Neck Cancer Treatment Market 2018 industry research report that covers overall business insights and forecast.



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Silent Cancer Therapeutics Market Forecast - Industry Value, Market Size, Top Companies and General Trends for 2018-2025 - TokensTree

Silent-Cancer-Therapeutics-194328.jpg

Silent Cancer Therapeutics Market Forecast - Industry Value, Market Size, Top Companies and General Trends for 2018-2025  TokensTree

Global Silent Cancer Therapeutics Market report describes elements such as dominating companies, types, applications, classification, size, SWOT analysis, ...



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Global Head and Neck Cancer Treatment Market: Global Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2025 - DailyHover

Global Head and Neck Cancer Treatment Market: Global Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2025  DailyHover

Market.Biz Presents Global Head and Neck Cancer Treatment Market 2018 industry research report that covers overall business insights and forecast.



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WWII Vet and Coors Light Fan Shares Secret to Longevity - NHL.com

WWII Vet and Coors Light Fan Shares Secret to Longevity  NHL.com

Andrew Slavonic, a 101-year-old World War II veteran from McMurray, says his secret to a long life is drinking a Coors Light every day at 4 p.m..



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WWII Vet and Coors Light Fan Shares Secret to Longevity - NHL.com

WWII Vet and Coors Light Fan Shares Secret to Longevity  NHL.com

Andrew Slavonic, a 101-year-old World War II veteran from McMurray, says his secret to a long life is drinking a Coors Light every day at 4 p.m..



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Wade GW & Cut Stake in Eaton Vance (EV) as Stock Price Declined; Veracyte (VCYT) Shareholder Cannell Capital Lowered Its Position by $5.87 Million - The FinExaminer

VCYT.png

Wade GW & Cut Stake in Eaton Vance (EV) as Stock Price Declined; Veracyte (VCYT) Shareholder Cannell Capital Lowered Its Position by $5.87 Million  The FinExaminer

Wade G W & Inc decreased its stake in Eaton Vance Corp (EV) by 6.54% based on its latest 2018Q3 regulatory filing with the SEC. Wade G W & Inc sold 7345 ...



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Chronic regional intestinal inflammatory disease: a trans-species slow infection?

Publication date: Available online 15 December 2018Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Ana Balseiro, Valentin Perez, Ramon A. JusteAbstractCrohn's disease and ulcerative colitis in humans and paratuberculosis in domestic and wild ruminants can be defined as chronic regional intestinal inflammatory diseases (CRIID). This review is a literature overview on these diseases in humans, non-human primates, dogs, cats, rabbits, equids and ruminants with a focus on pathological and microbiological features aimed identifying common characteristics that could lead to a unified pathological classification for a better understanding of their mechanisms and causes. The result is a framework of inflammatory forms throughout the different species indicative of ...

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Evaluation of Epstein-Barr virus-specific antibodies in Cypriot multiple sclerosis patients

This study aims to evaluate for the first time the seroprevalence of EBV in Cypriot MS patients. The serum of 133 MS patients and 101 healthy controls (HCs) was used to determine the positivity index of the EBV nuclear antigen-1 (EBNA-1) IgG, viral capsid antigen (VCA) IgG, and early antigen-D (EA-D) IgG, using ELISA. All MS patients were seropositive for both EBNA-1 IgG and VCA IgG as compared to 94.1% (Fisher's exact test, p = 0.0059) and 93.1% (Fisher's exact test, p = 0.0025) of HCs respectively. Furthermore, the positivity indexes of both antibodies were significantly higher in MS patients. There was no significant difference in the presence/absence of EA-D IgG between the two groups nor in the corresponding P.I. levels. The results obtained, revealing higher seropositivit...

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Antifungal activities of surfactant protein D in an environment closely mimicking the lung lining

In this study the localization and antifungal activity of the lung surfactant protein D (SP-D) was studied in an environment mimicking the lung lining. To this end Calu-3 cells were grown on an air-liquid interface allowing them to polarize and to produce mucus at their apical surface. Additionally, neutrophils were added to study their role in fungal clearance. Two fungal pathogens were used for these experiments: Candida albicans and Aspergillus fumigatus, both of clinical relevance. During fungal infection SP-D localized strongly to both fungal surfaces and stayed bound through the different stages of infection. Furthermore, SP-D decreased fungal adhesion to the epithelium and increased fungal clearance by neutrophils from the epithelial surface. These findings suggest that SP-D plays a...

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Next-generation sequencing reveals new insights about gene usage and CDR-H3 composition in the horse antibody repertoire

Publication date: January 2019Source: Molecular Immunology, Volume 105Author(s): Taciana Conceição Manso, Michele Groenner-Penna, João Carlos Minozzo, Bruno Cesar Antunes, Gregory C. Ippolito, Franck Molina, Liza F. FelicoriAbstractHorse serum antibodies have been used for greater than a century for the treatment and prophylaxis of infectious diseases and envenomations. Little is known, however, about the immunogenetic diversity that produces horse serum antibodies. Here, we employed next-generation sequencing for a first-in-kind comprehensive analysis of the equine B-cell repertoire. Nearly 45,000 and 30,000 clonotypes were obtained for the heavy-chain (IGH) and lambda light-chain (IGL) loci, respectively. We observed skewed use of the common subgroups IGHV2 (92.49%) and IGLV8 (82.50%)...

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IL-17A contributes to myocardial ischemic injury by activating NLRP3 inflammasome in macrophages through AMPKα/p38MAPK/ERK1/2 signal pathway in mice

ConclusionIL-17A aggravates inflammatory response during AMI by inducing macrophages infiltration and activating NLRP3 inflammasome through AMPKα/p38MAPK/ERK1/2 pathway. (Source: Molecular Immunology)

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Don't Let Holiday Season Stress Worsen Your Allergies, Asthma

SUNDAY, Dec. 16, 2018 -- Reducing stress could cut your risk of allergy and asthma symptoms during the holidays. " Studies show stress can cause a number of negative health effects, including causing more symptoms for allergy and asthma sufferers, " ... (Source: Drugs.com - Daily MedNews)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



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Here are some of the best remedies for your seasonal allergies

(Natural News) Spring is a season of new beginnings, not just for flowering plants and trees, but also for seasonal allergies. No matter how much some people might want to enjoy the beauty that comes with the season, they just can't because they're already preoccupied with sneezing and wiping their runny noses and watery eyes. Although there are... (Source: NaturalNews.com)

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Wade GW & Cut Stake in Eaton Vance (EV) as Stock Price Declined; Veracyte (VCYT) Shareholder Cannell Capital Lowered Its Position by $5.87 Million - The FinExaminer

VCYT.png

Wade GW & Cut Stake in Eaton Vance (EV) as Stock Price Declined; Veracyte (VCYT) Shareholder Cannell Capital Lowered Its Position by $5.87 Million  The FinExaminer

Wade G W & Inc decreased its stake in Eaton Vance Corp (EV) by 6.54% based on its latest 2018Q3 regulatory filing with the SEC. Wade G W & Inc sold 7345 ...



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Chronic regional intestinal inflammatory disease: a trans-species slow infection?

Publication date: Available online 15 December 2018Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Ana Balseiro, Valentin Perez, Ramon A. JusteAbstractCrohn's disease and ulcerative colitis in humans and paratuberculosis in domestic and wild ruminants can be defined as chronic regional intestinal inflammatory diseases (CRIID). This review is a literature overview on these diseases in humans, non-human primates, dogs, cats, rabbits, equids and ruminants with a focus on pathological and microbiological features aimed identifying common characteristics that could lead to a unified pathological classification for a better understanding of their mechanisms and causes. The result is a framework of inflammatory forms throughout the different species indicative of ...

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Evaluation of Epstein-Barr virus-specific antibodies in Cypriot multiple sclerosis patients

This study aims to evaluate for the first time the seroprevalence of EBV in Cypriot MS patients. The serum of 133 MS patients and 101 healthy controls (HCs) was used to determine the positivity index of the EBV nuclear antigen-1 (EBNA-1) IgG, viral capsid antigen (VCA) IgG, and early antigen-D (EA-D) IgG, using ELISA. All MS patients were seropositive for both EBNA-1 IgG and VCA IgG as compared to 94.1% (Fisher's exact test, p = 0.0059) and 93.1% (Fisher's exact test, p = 0.0025) of HCs respectively. Furthermore, the positivity indexes of both antibodies were significantly higher in MS patients. There was no significant difference in the presence/absence of EA-D IgG between the two groups nor in the corresponding P.I. levels. The results obtained, revealing higher seropositivit...

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Next-generation sequencing reveals new insights about gene usage and CDR-H3 composition in the horse antibody repertoire

Publication date: January 2019Source: Molecular Immunology, Volume 105Author(s): Taciana Conceição Manso, Michele Groenner-Penna, João Carlos Minozzo, Bruno Cesar Antunes, Gregory C. Ippolito, Franck Molina, Liza F. FelicoriAbstractHorse serum antibodies have been used for greater than a century for the treatment and prophylaxis of infectious diseases and envenomations. Little is known, however, about the immunogenetic diversity that produces horse serum antibodies. Here, we employed next-generation sequencing for a first-in-kind comprehensive analysis of the equine B-cell repertoire. Nearly 45,000 and 30,000 clonotypes were obtained for the heavy-chain (IGH) and lambda light-chain (IGL) loci, respectively. We observed skewed use of the common subgroups IGHV2 (92.49%) and IGLV8 (82.50%)...

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Antifungal activities of surfactant protein D in an environment closely mimicking the lung lining

In this study the localization and antifungal activity of the lung surfactant protein D (SP-D) was studied in an environment mimicking the lung lining. To this end Calu-3 cells were grown on an air-liquid interface allowing them to polarize and to produce mucus at their apical surface. Additionally, neutrophils were added to study their role in fungal clearance. Two fungal pathogens were used for these experiments: Candida albicans and Aspergillus fumigatus, both of clinical relevance. During fungal infection SP-D localized strongly to both fungal surfaces and stayed bound through the different stages of infection. Furthermore, SP-D decreased fungal adhesion to the epithelium and increased fungal clearance by neutrophils from the epithelial surface. These findings suggest that SP-D plays a...

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IL-17A contributes to myocardial ischemic injury by activating NLRP3 inflammasome in macrophages through AMPKα/p38MAPK/ERK1/2 signal pathway in mice

ConclusionIL-17A aggravates inflammatory response during AMI by inducing macrophages infiltration and activating NLRP3 inflammasome through AMPKα/p38MAPK/ERK1/2 pathway. (Source: Molecular Immunology)

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Don't Let Holiday Season Stress Worsen Your Allergies, Asthma

SUNDAY, Dec. 16, 2018 -- Reducing stress could cut your risk of allergy and asthma symptoms during the holidays. " Studies show stress can cause a number of negative health effects, including causing more symptoms for allergy and asthma sufferers, " ... (Source: Drugs.com - Daily MedNews)

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Here are some of the best remedies for your seasonal allergies

(Natural News) Spring is a season of new beginnings, not just for flowering plants and trees, but also for seasonal allergies. No matter how much some people might want to enjoy the beauty that comes with the season, they just can't because they're already preoccupied with sneezing and wiping their runny noses and watery eyes. Although there are... (Source: NaturalNews.com)

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Top News in Pediatrics December 13 2018 (11 of 14) - MD Linx

Top News in Pediatrics December 13 2018 (11 of 14)  MD Linx

If someone told you there was a vaccine that could prevent most cases of cervical cancer—and a growing number of head and neck cancers—would you get it?



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The most common symptoms of cancer, which are important to know - www.MICEtimes.asia

eeea95943eac6aada1a20cc99ac77992.jpg

The most common symptoms of cancer, which are important to know  www.MICEtimes.asia

It is important to notice. In most cases treatment in a hospital – this is the 3-4 stage of cancer. How to understand that the body may had cancer. Oncologists have ...



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Top News in Pediatrics December 13 2018 (11 of 14) - MD Linx

Top News in Pediatrics December 13 2018 (11 of 14)  MD Linx

If someone told you there was a vaccine that could prevent most cases of cervical cancer—and a growing number of head and neck cancers—would you get it?



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The most common symptoms of cancer, which are important to know - www.MICEtimes.asia

eeea95943eac6aada1a20cc99ac77992.jpg

The most common symptoms of cancer, which are important to know  www.MICEtimes.asia

It is important to notice. In most cases treatment in a hospital – this is the 3-4 stage of cancer. How to understand that the body may had cancer. Oncologists have ...



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Excess body weight responsible for nearly 4 percent of cancers worldwide - EurekAlert

Excess body weight responsible for nearly 4 percent of cancers worldwide  EurekAlert

Excess body weight accounted for approximately 3.9 percent of all cancers worldwide in 2012, a figure that is expected to rise in the coming decades given ...



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Excess body weight responsible for nearly 4 percent of cancers worldwide - EurekAlert

Excess body weight responsible for nearly 4 percent of cancers worldwide  EurekAlert

Excess body weight accounted for approximately 3.9 percent of all cancers worldwide in 2012, a figure that is expected to rise in the coming decades given ...



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Pharma Stock Roundup: AZN, RHHBY Cancer Drugs, LLY, BMY New Deals in Focus - Zacks.com

price%20chart%2012-14-2018.jpg

Pharma Stock Roundup: AZN, RHHBY Cancer Drugs, LLY, BMY New Deals in Focus  Zacks.com

AstraZeneca's (AZN) Imfinzi misses endpoint in study. Roche's (RHHBY) cancer drug combo gets FDA nod for first-line lung cancer. Lilly (LLY) & Bristol Myers ...



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2018-2023 Global Drugs for Differentiated Thyroid Cancer Market Status and Market Key Players - The Flatland Post

image.png

2018-2023 Global Drugs for Differentiated Thyroid Cancer Market Status and Market Key Players  The Flatland Post

The Global Global Drugs for Differentiated Thyroid Cancer Market 2018 by Manufacturers, Regions, Type and Application, Forecast to 2023: Drugs for ...



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Pharma Stock Roundup: AZN, RHHBY Cancer Drugs, LLY, BMY New Deals in Focus - Zacks.com

price%20chart%2012-14-2018.jpg

Pharma Stock Roundup: AZN, RHHBY Cancer Drugs, LLY, BMY New Deals in Focus  Zacks.com

AstraZeneca's (AZN) Imfinzi misses endpoint in study. Roche's (RHHBY) cancer drug combo gets FDA nod for first-line lung cancer. Lilly (LLY) & Bristol Myers ...



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2018-2023 Global Drugs for Differentiated Thyroid Cancer Market Status and Market Key Players - The Flatland Post

image.png

2018-2023 Global Drugs for Differentiated Thyroid Cancer Market Status and Market Key Players  The Flatland Post

The Global Global Drugs for Differentiated Thyroid Cancer Market 2018 by Manufacturers, Regions, Type and Application, Forecast to 2023: Drugs for ...



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The new Cancer Drugs Fund has quietly reached a significant milestone - Cancer Research UK

Drug_hero-hero.jpg

The new Cancer Drugs Fund has quietly reached a significant milestone  Cancer Research UK

A revamped Cancer Drugs Fund is giving patients new options and renewed chances of successful treatment, quicker than ever before.



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Huawei CFO Meng Wanzhou cites multi-million dollar homes in Vancouver and health issues in bail bid - The Straits Times

ak_menghouse1_1012.jpg

Huawei CFO Meng Wanzhou cites multi-million dollar homes in Vancouver and health issues in bail bid  The Straits Times

VANCOUVER (BLOOMBERG) - Ms Meng Wanzhou suffers from hypertension and struggles to eat solid food. She has a sleep disorder. She is willing to put up a ...



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Huawei CFO Meng Wanzhou cites multi-million dollar homes in Vancouver and health issues in bail bid - The Straits Times

ak_menghouse1_1012.jpg

Huawei CFO Meng Wanzhou cites multi-million dollar homes in Vancouver and health issues in bail bid  The Straits Times

VANCOUVER (BLOOMBERG) - Ms Meng Wanzhou suffers from hypertension and struggles to eat solid food. She has a sleep disorder. She is willing to put up a ...



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The new Cancer Drugs Fund has quietly reached a significant milestone - Cancer Research UK

Drug_hero-hero.jpg

The new Cancer Drugs Fund has quietly reached a significant milestone  Cancer Research UK

A revamped Cancer Drugs Fund is giving patients new options and renewed chances of successful treatment, quicker than ever before.



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Clinical and histopathologic prognostic implications of the expression of cytokeratins 8, 10, 13, 14, 16, 18 and 19 in oral and oropharyngeal squamous cell carcinoma

Publication date: Available online 16 December 2018

Source: Archives of Oral Biology

Author(s): Rima-A. Safadi, Niveen-I. Abdullah, Rolla-F. Alaaraj, Dima H. Bader, Darshan D. Divakar, Abed H. Hamasha, Maher A. Sughayer

ABSTRACT
Objectives

To identify cytokeratins (CK) of significant correlations with clinical and histopathologic prognostic parameters in oral and oropharyngeal squamous cell carcinoma (SCC).

Design

The sample consisted of 100 cases retrieved from the archives of the Pathology Department/ King Hussein Cancer Center/Amman/ Jordan. Recorded data included: age, gender, location, grade, depth of invasion, the presence of epithelial dysplasia, tumor size, lymph node metastasis, number of positive lymph nodes, distant metastases, clinical stage, local recurrence, treatment modalities and 5-year survival rate. Immunohistochemical staining of 6 cytokeratins: 8, 10, 13, 14, 16, 18, and 19 was performed using standard protocols. Stained sections were digitized and analyzed using ImageJ-color deconvolution to identify the percentage of cytokeratin-positive area (score). Statistical tests used were: student t-test, analysis of variance, bivariate analysis and logistic regression.

Results

Lower CK8,18, 19 scores correlated with lower 5-year survival rate. Higher CK19 and lower CK 10, 14, 16 scores were associated with distant metastasis. Increased CK8, 18, 19 scores correlated with higher stage and with higher depth of invasion. The higher CK18 score was associated with local recurrence. Higher CK10, 13, 16 scores correlated with well-differentiated grade. Higher CK19 and lower CK16 scores were associated with adjacent epithelial dysplasia. Regression analysis showed that better 5-year survival rate was significantly correlated with increased CK16, decreased CK18 and 19 scores.

Conclusion

Expression scores of a panel of cytokeratin are potential prognostic indicators for 5-year survival and correlates with other prognostic parameters.



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Salivary opiorphin in dental pain: a potential biomarker for dental disease

Publication date: Available online 15 December 2018

Source: Archives of Oral Biology

Author(s): Mahmut Sertac Ozdogan, Mustafa Gungormus, Selen Ince Yusufoglu, Sinan Yasin Ertem, Cigdem Sonmez, Metin Orhan

Abstract
Objectives

Opiorphin is a recently discovered peptide shown to inhibit the enkephalin-degrading enzymes and prolong the effects of enkephalins. Although opiorphin is found in high concentrations in saliva, the relationship between salivary opiorphin and orofacial pains is not yet fully understood. We aimed to determine salivary opiorphin concentrations in dental pain related to symptomatic irreversible pulpitis (SIP), and symptomatic periapical periodontitis (SAP).

Design

39 patients participated in this study. The participants were categorized into SIP and SAP based on their diagnosis. All the patients were treated with root canal treatment. Saliva specimens were collected, and pain levels were recorded at pre-treatment, 7 days post-treatment and 30 days post-treatment. Saliva opiorphin levels were measured using a commercially available ELISA kit. Pre-treatment and post-treatment opiorphin levels were evaluated using repeated measures ANOVA. Correlations between VAS scores, opiorphin levels and age were evaluated using Spearman's Rank Correlation.

Results

The average saliva opiorphin level pre-treatment, 7 days post-treatment and 30 days post-treatment were 31.28 ± 7.10 ng/ml, 20.41 ± 2.67 ng/ml and 18.61 ± 2.05 ng/ml respectively. Significantly higher pre-treatment opiorphin levels were observed in the SIP group compared to the SAP group. A strong correlation was observed between the pre-treatment pain levels and the saliva opiorphin concentrations.

Conclusions

Our findings indicate that saliva opiorphin levels increase in inflammation related dental pain. The level of salivary opiorphin is strongly correlated with the reported level of pain. The extent of the inflammation (pulpal vs. periodontal) also affects the opiorphin level.



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Clinical and histopathologic prognostic implications of the expression of cytokeratins 8, 10, 13, 14, 16, 18 and 19 in oral and oropharyngeal squamous cell carcinoma

Publication date: Available online 16 December 2018

Source: Archives of Oral Biology

Author(s): Rima-A. Safadi, Niveen-I. Abdullah, Rolla-F. Alaaraj, Dima H. Bader, Darshan D. Divakar, Abed H. Hamasha, Maher A. Sughayer

ABSTRACT
Objectives

To identify cytokeratins (CK) of significant correlations with clinical and histopathologic prognostic parameters in oral and oropharyngeal squamous cell carcinoma (SCC).

Design

The sample consisted of 100 cases retrieved from the archives of the Pathology Department/ King Hussein Cancer Center/Amman/ Jordan. Recorded data included: age, gender, location, grade, depth of invasion, the presence of epithelial dysplasia, tumor size, lymph node metastasis, number of positive lymph nodes, distant metastases, clinical stage, local recurrence, treatment modalities and 5-year survival rate. Immunohistochemical staining of 6 cytokeratins: 8, 10, 13, 14, 16, 18, and 19 was performed using standard protocols. Stained sections were digitized and analyzed using ImageJ-color deconvolution to identify the percentage of cytokeratin-positive area (score). Statistical tests used were: student t-test, analysis of variance, bivariate analysis and logistic regression.

Results

Lower CK8,18, 19 scores correlated with lower 5-year survival rate. Higher CK19 and lower CK 10, 14, 16 scores were associated with distant metastasis. Increased CK8, 18, 19 scores correlated with higher stage and with higher depth of invasion. The higher CK18 score was associated with local recurrence. Higher CK10, 13, 16 scores correlated with well-differentiated grade. Higher CK19 and lower CK16 scores were associated with adjacent epithelial dysplasia. Regression analysis showed that better 5-year survival rate was significantly correlated with increased CK16, decreased CK18 and 19 scores.

Conclusion

Expression scores of a panel of cytokeratin are potential prognostic indicators for 5-year survival and correlates with other prognostic parameters.



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Salivary opiorphin in dental pain: a potential biomarker for dental disease

Publication date: Available online 15 December 2018

Source: Archives of Oral Biology

Author(s): Mahmut Sertac Ozdogan, Mustafa Gungormus, Selen Ince Yusufoglu, Sinan Yasin Ertem, Cigdem Sonmez, Metin Orhan

Abstract
Objectives

Opiorphin is a recently discovered peptide shown to inhibit the enkephalin-degrading enzymes and prolong the effects of enkephalins. Although opiorphin is found in high concentrations in saliva, the relationship between salivary opiorphin and orofacial pains is not yet fully understood. We aimed to determine salivary opiorphin concentrations in dental pain related to symptomatic irreversible pulpitis (SIP), and symptomatic periapical periodontitis (SAP).

Design

39 patients participated in this study. The participants were categorized into SIP and SAP based on their diagnosis. All the patients were treated with root canal treatment. Saliva specimens were collected, and pain levels were recorded at pre-treatment, 7 days post-treatment and 30 days post-treatment. Saliva opiorphin levels were measured using a commercially available ELISA kit. Pre-treatment and post-treatment opiorphin levels were evaluated using repeated measures ANOVA. Correlations between VAS scores, opiorphin levels and age were evaluated using Spearman's Rank Correlation.

Results

The average saliva opiorphin level pre-treatment, 7 days post-treatment and 30 days post-treatment were 31.28 ± 7.10 ng/ml, 20.41 ± 2.67 ng/ml and 18.61 ± 2.05 ng/ml respectively. Significantly higher pre-treatment opiorphin levels were observed in the SIP group compared to the SAP group. A strong correlation was observed between the pre-treatment pain levels and the saliva opiorphin concentrations.

Conclusions

Our findings indicate that saliva opiorphin levels increase in inflammation related dental pain. The level of salivary opiorphin is strongly correlated with the reported level of pain. The extent of the inflammation (pulpal vs. periodontal) also affects the opiorphin level.



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A Personal HPV Story: Former Senator Norm Coleman - PrecisionVaccinations

A Personal HPV Story: Former Senator Norm Coleman  PrecisionVaccinations

Former Minnesota Senator Norm Coleman is sharing a message of strength and awareness during his second battle with cancer, reported CBS Minnesota.



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Finding a cure for HPV-related cancers - 10News

Finding a cure for HPV-related cancers  10News

The widow of a man who died from HPV-related cancer continues to fight for a cure.



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A Personal HPV Story: Former Senator Norm Coleman - PrecisionVaccinations

A Personal HPV Story: Former Senator Norm Coleman  PrecisionVaccinations

Former Minnesota Senator Norm Coleman is sharing a message of strength and awareness during his second battle with cancer, reported CBS Minnesota.



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Finding a cure for HPV-related cancers - 10News

Finding a cure for HPV-related cancers  10News

The widow of a man who died from HPV-related cancer continues to fight for a cure.



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Asfotase alfa for infants and young children with hypophosphatasia: 7 year outcomes of a single-arm, open-label, phase 2 extension trial

This study and extension phase are registered with ClinicalTrials.gov, number NCT01205152, and EudraCT, number 2009-009369-32.Findings11 participants were recruited between Oct 6, 2008, and Dec 4, 2009. Ten patients completed a 6 month treatment period and entered the extension phase; nine received asfotase alfa for at least 6 years and completed the study, with four being treated for more than 7 years. Skeletal healing was sustained over 7 years of treatment; all evaluable patients had RGI-C scores of at least +2 at year 6 (n=9; median score +2·0 [range 2·0–3·0]) and year 7 (n=7; median score +2·3 [2·0–3·0]). No patient who completed the study required respiratory support after year 4. Weight Z scores improved to within normal range from year 3 to study end; length or height Z s...

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Electrophysiological and behavioral measures of some speech contrasts in varied attention and noise.

Authors: Morris DJ, Tøndering J, Lindgren M Abstract This paper investigates the salience of speech contrasts in noise, in relation to how listening attention affects scalp-recorded cortical responses. The contrasts that were examined with consonant-vowel syllables, were place of articulation, vowel length and voice-onset time (VOT) and our analysis focuses on the correspondence between the effect of attention on the electrophysiology and the decrement in behavioral results when noise was added to the stimuli. Normal-hearing subjects (n = 20) performed closed-set syllable identification in no noise, 0, 4 and 8 dB signal-noise ratio (SNR). Identification in noise decreased markedly for place of articulation, moderately for vowel length and marginally for VOT. The same syllabl...

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Asfotase alfa for infants and young children with hypophosphatasia: 7 year outcomes of a single-arm, open-label, phase 2 extension trial

This study and extension phase are registered with ClinicalTrials.gov, number NCT01205152, and EudraCT, number 2009-009369-32.Findings11 participants were recruited between Oct 6, 2008, and Dec 4, 2009. Ten patients completed a 6 month treatment period and entered the extension phase; nine received asfotase alfa for at least 6 years and completed the study, with four being treated for more than 7 years. Skeletal healing was sustained over 7 years of treatment; all evaluable patients had RGI-C scores of at least +2 at year 6 (n=9; median score +2·0 [range 2·0–3·0]) and year 7 (n=7; median score +2·3 [2·0–3·0]). No patient who completed the study required respiratory support after year 4. Weight Z scores improved to within normal range from year 3 to study end; length or height Z s...

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Electrophysiological and behavioral measures of some speech contrasts in varied attention and noise.

Authors: Morris DJ, Tøndering J, Lindgren M Abstract This paper investigates the salience of speech contrasts in noise, in relation to how listening attention affects scalp-recorded cortical responses. The contrasts that were examined with consonant-vowel syllables, were place of articulation, vowel length and voice-onset time (VOT) and our analysis focuses on the correspondence between the effect of attention on the electrophysiology and the decrement in behavioral results when noise was added to the stimuli. Normal-hearing subjects (n = 20) performed closed-set syllable identification in no noise, 0, 4 and 8 dB signal-noise ratio (SNR). Identification in noise decreased markedly for place of articulation, moderately for vowel length and marginally for VOT. The same syllabl...

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The power of language: functional brain network topology of deaf and hearing in relation to sign language experience

Publication date: Available online 15 December 2018

Source: Hearing Research

Author(s): Michel R.T. Sinke, Jan W. Buitenhuis, Frank van der Maas, Job Nwiboko, Rick M. Dijkhuizen, Eric van Diessen, Willem M. Otte

Abstract

Prolonged auditory sensory deprivation leads to brain reorganization. This is indicated by functional enhancement in remaining sensory systems and known as cross-modal plasticity. In this study we investigated differences in functional brain network topology between deaf and hearing individuals. We also studied altered functional network responses between deaf and hearing individuals with a recording paradigm containing an eyes-closed and eyes-open condition.

Electroencephalography activity was recorded in a group of sign language-trained deaf (N = 71) and hearing people (N = 122) living in rural Africa. Functional brain networks were constructed from the functional connectivity between fourteen electrodes distributed over the scalp. Functional connectivity was quantified with the phase lag index based on bandpass filtered epochs of brain signal. We studied the functional connectivity between the auditory, somatosensory and visual cortex and performed whole-brain minimum spanning tree analysis to capture network backbone characteristics.

Functional connectivity between different regions involved in sensory information processing tended to be stronger in deaf people during the eyes-closed condition in both the alpha and beta frequency band. Furthermore, we found differences in functional backbone topology between deaf and hearing individuals. The backbone topology altered during transition from the eyes-closed to eyes-open condition irrespective of deafness, but was more pronounced in deaf individuals. The transition of backbone strength was different between individuals with congenital, pre-lingual or post-lingual deafness. Functional backbone characteristics correlated with the experience of sign language. Overall, our study revealed more insights in functional network reorganization caused by auditory deprivation and cross-modal plasticity. It further supports the idea of a brain plasticity potential in deaf and hearing people. The association between network organization and acquired sign language experience reflects the ability of ongoing brain adaptation in people with hearing disabilities.



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