We describe what is to our knowledge the first report of both oncocytic cysts and an oncocytic cystadenoma adjacent to a pleomorphic adenoma of the parotid gland. (Source: The British Journal of Oral and Maxillofacial Surgery)
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Δευτέρα 3 Δεκεμβρίου 2018
Oncocytic cystadenoma and oncocytic cysts of the parotid gland occurring synchronously with a pleomorphic adenoma
Improving CarE for Community Acquired Pneumonia
Condition: Pneumonia Childhood Intervention: Behavioral: Decision Support Sponsors: Vanderbilt University Medical Center; National Institute of Allergy and Infectious Diseases (NIAID); University of Utah; Intermountain Health Care, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
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HAL-MRE1 Subcutaneous Immunotherapy in Ragweed Allergic Patients First-in-human
Conditions: Rhinitis, Allergic; Rhinoconjunctivitis, Allergic Intervention: Biological: HAL-MRE1 Sponsor: HAL Allergy Not yet recruiting (Source: ClinicalTrials.gov)
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Amoxicillin Challenge for Penicillin Allergy Diagnosis
Condition: Penicillin Allergy Intervention: Diagnostic Test: Penicillin Skin Testing Sponsor: CHU de Quebec-Universite Laval Not yet recruiting (Source: ClinicalTrials.gov)
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Demonstration of Equivalent Effectiveness of a Novel Anti-allergic Nasal Spray and a Marketed Nasal Product as Well as Demonstration of Fast Symptom Reduction in Allergic Patients
Conditions: Allergic Rhinitis; Allergic Conjunctivitis; Hayfever Interventions: Drug: Rhinocort; Drug: Budesolv; Other: Placebo Sponsor: Marinomed Biotech AG Enrolling by invitation (Source: ClinicalTrials.gov)
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No change in the teaching of oral and maxillofacial surgery to medical students
We read with interest the recent paper by Hamid et al.1 We commend them for publishing an excellent paper that further highlights the lack of teaching about oral and maxillofacial surgery (OMFS) and lack of awareness of the specialty among medical students.2 Their findings echo our own, as we showed that 72% (183/253) of English medical students and 85% (318/374) of Irish medical students3 had no exposure to it. Several years on, it seems that this has remained a trend, with 89% (178/200) of students1 having had no clinical exposure. (Source: The British Journal of Oral and Maxillofacial Surgery)
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HAL-MRE1 Subcutaneous Immunotherapy in Ragweed Allergic Patients First-in-human
Conditions: Rhinitis, Allergic; Rhinoconjunctivitis, Allergic Intervention: Biological: HAL-MRE1 Sponsor: HAL Allergy Not yet recruiting (Source: ClinicalTrials.gov)
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Amoxicillin Challenge for Penicillin Allergy Diagnosis
Condition: Penicillin Allergy Intervention: Diagnostic Test: Penicillin Skin Testing Sponsor: CHU de Quebec-Universite Laval Not yet recruiting (Source: ClinicalTrials.gov)
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A Study to Evaluate Safety, Tolerability and Immune Response in Adolescents Allergic to Peanut After Receiving Intradermal Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Lysosomal Associated Membrane Protein DNA Plasmid Vaccine
Condition: Peanut Allergy Interventions: Drug: ASP0892; Drug: Placebo Sponsor: Astellas Pharma Global Development, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
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Demonstration of Equivalent Effectiveness of a Novel Anti-allergic Nasal Spray and a Marketed Nasal Product as Well as Demonstration of Fast Symptom Reduction in Allergic Patients
Conditions: Allergic Rhinitis; Allergic Conjunctivitis; Hayfever Interventions: Drug: Rhinocort; Drug: Budesolv; Other: Placebo Sponsor: Marinomed Biotech AG Enrolling by invitation (Source: ClinicalTrials.gov)
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Predicting laryngeal exposure in microlaryngoscopy: External validation of the laryngoscore
Objectives
Optimal laryngeal exposure during transoral laryngeal surgery is fundamental. We aimed to evaluate the reliability of a recently proposed score (Laryngoscore) in predicting difficult laryngeal exposure (DLE) in an independent cohort of patients undergoing elective microlaryngoscopy. We also verified the relation between DLE, surgeon's expertise, and difficult intubation, and investigated possible areas for score improvement.
Study Design
Prospective validation study.
Methods
A total of 136 patients were preoperatively evaluated using the Laryngoscore. Patients were divided into three classes according to patient position, type of laryngoscope, and need for external counterpressure to expose the anterior commissure. Based on their mean scores, two groups were identified: good laryngeal exposure (GLE) and DLE. A receiver operating characteristic curve with the Youden index was used to calculate the optimal cutoff value. The χ2 and Fisher exact test were used to correlate GLE and DLE to the surgeon's expertise and difficult intubation. The intraoperative anatomical parameters underlying DLE were also recorded.
Results
The optimal cutoff value for differentiating GLE and DLE was 4, which identified 80.6% of DLE cases. No statistically significant difference in GLE and DLE distribution was found between surgeons (P = 0.43). The correlation between difficult intubation and DLE was statistically significant (P = 0.03). The intraoperative parameters determining DLE were epiglottis characteristics (floppy, tight, or short), bulky abdomen and chest, bulky tongue base, mobile teeth, and a narrow laryngeal aditus.
Conclusion
The Laryngoscore is reliable for detecting DLE preoperatively. The inclusion of additional parameters may allow a more complete assessment and maximize its diagnostic accuracy.
Level of Evidence
2b. Laryngoscope, 2018
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Predicting laryngeal exposure in microlaryngoscopy: External validation of the laryngoscore
Objectives
Optimal laryngeal exposure during transoral laryngeal surgery is fundamental. We aimed to evaluate the reliability of a recently proposed score (Laryngoscore) in predicting difficult laryngeal exposure (DLE) in an independent cohort of patients undergoing elective microlaryngoscopy. We also verified the relation between DLE, surgeon's expertise, and difficult intubation, and investigated possible areas for score improvement.
Study Design
Prospective validation study.
Methods
A total of 136 patients were preoperatively evaluated using the Laryngoscore. Patients were divided into three classes according to patient position, type of laryngoscope, and need for external counterpressure to expose the anterior commissure. Based on their mean scores, two groups were identified: good laryngeal exposure (GLE) and DLE. A receiver operating characteristic curve with the Youden index was used to calculate the optimal cutoff value. The χ2 and Fisher exact test were used to correlate GLE and DLE to the surgeon's expertise and difficult intubation. The intraoperative anatomical parameters underlying DLE were also recorded.
Results
The optimal cutoff value for differentiating GLE and DLE was 4, which identified 80.6% of DLE cases. No statistically significant difference in GLE and DLE distribution was found between surgeons (P = 0.43). The correlation between difficult intubation and DLE was statistically significant (P = 0.03). The intraoperative parameters determining DLE were epiglottis characteristics (floppy, tight, or short), bulky abdomen and chest, bulky tongue base, mobile teeth, and a narrow laryngeal aditus.
Conclusion
The Laryngoscore is reliable for detecting DLE preoperatively. The inclusion of additional parameters may allow a more complete assessment and maximize its diagnostic accuracy.
Level of Evidence
2b. Laryngoscope, 2018
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Quantification of liver iron overload disease with laser ablation inductively coupled plasma mass spectrometry
Abstract
Background
Hereditary hemochromatosis is the most frequent, identified, genetic disorder in Caucasians affecting about 1 in 1000 people of Northern European ancestry, where the associated genetic defect (homozygosity for the p.Cys282Tyr polymorphism in the HFE gene) has a prevalence of approximately 1:200. The disorder is characterized by excess iron stores in the body. Due to the incomplete disease penetrance of disease-associated genotype, genetic testing and accurate quantification of hepatic iron content by histological grading of stainable iron, quantitative chemical determination of iron, or imaging procedures are important in the evaluation and staging of hereditary hemochromatosis.
Methods
We here established novel laser ablation inductively coupled plasma mass spectrometry protocols for hepatic metal bio-imaging for diagnosis of iron overload.
Results
We demonstrate that these protocols are a significant asset in the diagnosis of iron overload allowing iron measurements and simultaneous determination of various other metals and metalloids with high sensitivity, spatial resolution, and quantification ability.
Conclusions
The simultaneous measurement of various metals and metalloids offers unique opportunities for deeper understanding of metal imbalances. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a highly powerful and sensitive technique for the analysis of a variety of solid samples with high spatial resolution. We conclude that this method is an important add-on to routine diagnosis of iron overload and associated hepatic metal dysbalances resulting thereof.
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Quantification of liver iron overload disease with laser ablation inductively coupled plasma mass spectrometry
Abstract
Background
Hereditary hemochromatosis is the most frequent, identified, genetic disorder in Caucasians affecting about 1 in 1000 people of Northern European ancestry, where the associated genetic defect (homozygosity for the p.Cys282Tyr polymorphism in the HFE gene) has a prevalence of approximately 1:200. The disorder is characterized by excess iron stores in the body. Due to the incomplete disease penetrance of disease-associated genotype, genetic testing and accurate quantification of hepatic iron content by histological grading of stainable iron, quantitative chemical determination of iron, or imaging procedures are important in the evaluation and staging of hereditary hemochromatosis.
Methods
We here established novel laser ablation inductively coupled plasma mass spectrometry protocols for hepatic metal bio-imaging for diagnosis of iron overload.
Results
We demonstrate that these protocols are a significant asset in the diagnosis of iron overload allowing iron measurements and simultaneous determination of various other metals and metalloids with high sensitivity, spatial resolution, and quantification ability.
Conclusions
The simultaneous measurement of various metals and metalloids offers unique opportunities for deeper understanding of metal imbalances. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a highly powerful and sensitive technique for the analysis of a variety of solid samples with high spatial resolution. We conclude that this method is an important add-on to routine diagnosis of iron overload and associated hepatic metal dysbalances resulting thereof.
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Abstracts of 28th Year Annual Meeting of Turkish Society of Neuroradiology with International Participation, Conrad Istanbul Bosphorus, Istanbul, Turkey, February 15-17, 2019
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Abstracts of 28th Year Annual Meeting of Turkish Society of Neuroradiology with International Participation, Conrad Istanbul Bosphorus, Istanbul, Turkey, February 15-17, 2019
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Oral diseases and socio-demographic factors in adolescents living in Maasai population areas of Tanzania: a cross-sectional study
Abstract
Background
Oral diseases may cause serious health problems, especially in socially disadvantaged populations and in low-income countries. In populations living in the rural areas of Tanzania there is paucity of reports on oral health. The study aim was to estimate the prevalence, severity and socio-demographic distribution of oral diseases/conditions in adolescents living in Maasai population areas of Tanzania and to compare oral diseases/conditions between Maasai and non-Maasai ethnic groups.
Methods
A total of 23 schools were randomly selected from 66 rural public primary schools in Monduli and Longido districts, Tanzania. All pupils in the selected classes, 6th grade, were invited to participate in the study. A total of 989 were invited and 906 (91.6%) accepted the invitation and completed an interview and a clinical oral examination.
Results
Out of 906 study participants (age range 12–17 years), 721(79.6%) were from Maasai and 185 (20.4%) from non-Maasai ethnic groups. Prevalence of poor oral hygiene, gingival bleeding, dental caries experience (DMFT> 0), dental fluorosis TF grade 5–9, dental erosion (into dentin), tooth wear (into dentin) and TMD was 65.6, 40.9, 8.8, 48.6, 1.9, 16.5 and 11.8%, respectively. Multiple variable logistic regression analysis revealed that, girls (OR = 2.0) and participants from Longido (OR = 2.6) were more likely to present with good oral hygiene (p < 0.05). Adolescents from Monduli (OR = 1.7), males (OR = 2.1), being born within Arusha region (OR = 1.9) and Maasai (OR = 1.7) were more likely to present with gingival bleeding (p < 0.05). DMFT> 0 increased by age (OR = 2.0) and was associated with non-Maasai ethnic group (OR = 2.2), (p < 0.05). Adolescents from Monduli district (OR = 10.0) and those born in Arusha region (OR = 3.2) were more likely to present with dental fluorosis (p < 0.05). Dental erosion was more common among non-Maasais (OR = 2.0) as well as having mother with high education (OR = 2.3), (p < 0.05).
Conclusions
Oral diseases like dental caries and dental erosion were less common, but gingival bleeding, dental fluorosis, tooth wear and TMD were common findings in adolescents attending primary schools in the Maasai population areas of Tanzania. Notable differences between Maasai and non-Maasai ethnic groups and certain correlations to sociodemographic factors were detected. Our findings can be utilized by policy makers in the planning of oral health programs in public primary schools of Maasai population areas of Tanzania.
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Despite What We May Think, Diagnosing Asthma Isn't Easy Despite What We May Think, Diagnosing Asthma Isn't Easy
Dr Aaron Holley on the surprising challenges in diagnosing this increasingly prevalent condition, and how to surmount them.Medscape Critical Care (Source: Medscape Allergy Headlines)
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Lanadelumab Prevents Hereditary Angioedema Attacks Lanadelumab Prevents Hereditary Angioedema Attacks
Treatment with lanadelumab significantly reduced attacks of hereditary angioedema (HAE) type I and II in the phase 3 randomized controlled HELP study, supporting its use as a prophylactic therapy for HAE, researchers say.Reuters Health Information (Source: Medscape Allergy Headlines)
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Oral diseases and socio-demographic factors in adolescents living in Maasai population areas of Tanzania: a cross-sectional study
Abstract
Background
Oral diseases may cause serious health problems, especially in socially disadvantaged populations and in low-income countries. In populations living in the rural areas of Tanzania there is paucity of reports on oral health. The study aim was to estimate the prevalence, severity and socio-demographic distribution of oral diseases/conditions in adolescents living in Maasai population areas of Tanzania and to compare oral diseases/conditions between Maasai and non-Maasai ethnic groups.
Methods
A total of 23 schools were randomly selected from 66 rural public primary schools in Monduli and Longido districts, Tanzania. All pupils in the selected classes, 6th grade, were invited to participate in the study. A total of 989 were invited and 906 (91.6%) accepted the invitation and completed an interview and a clinical oral examination.
Results
Out of 906 study participants (age range 12–17 years), 721(79.6%) were from Maasai and 185 (20.4%) from non-Maasai ethnic groups. Prevalence of poor oral hygiene, gingival bleeding, dental caries experience (DMFT> 0), dental fluorosis TF grade 5–9, dental erosion (into dentin), tooth wear (into dentin) and TMD was 65.6, 40.9, 8.8, 48.6, 1.9, 16.5 and 11.8%, respectively. Multiple variable logistic regression analysis revealed that, girls (OR = 2.0) and participants from Longido (OR = 2.6) were more likely to present with good oral hygiene (p < 0.05). Adolescents from Monduli (OR = 1.7), males (OR = 2.1), being born within Arusha region (OR = 1.9) and Maasai (OR = 1.7) were more likely to present with gingival bleeding (p < 0.05). DMFT> 0 increased by age (OR = 2.0) and was associated with non-Maasai ethnic group (OR = 2.2), (p < 0.05). Adolescents from Monduli district (OR = 10.0) and those born in Arusha region (OR = 3.2) were more likely to present with dental fluorosis (p < 0.05). Dental erosion was more common among non-Maasais (OR = 2.0) as well as having mother with high education (OR = 2.3), (p < 0.05).
Conclusions
Oral diseases like dental caries and dental erosion were less common, but gingival bleeding, dental fluorosis, tooth wear and TMD were common findings in adolescents attending primary schools in the Maasai population areas of Tanzania. Notable differences between Maasai and non-Maasai ethnic groups and certain correlations to sociodemographic factors were detected. Our findings can be utilized by policy makers in the planning of oral health programs in public primary schools of Maasai population areas of Tanzania.
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Despite What We May Think, Diagnosing Asthma Isn't Easy Despite What We May Think, Diagnosing Asthma Isn't Easy
Dr Aaron Holley on the surprising challenges in diagnosing this increasingly prevalent condition, and how to surmount them.Medscape Critical Care (Source: Medscape Allergy Headlines)
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Lanadelumab Prevents Hereditary Angioedema Attacks Lanadelumab Prevents Hereditary Angioedema Attacks
Treatment with lanadelumab significantly reduced attacks of hereditary angioedema (HAE) type I and II in the phase 3 randomized controlled HELP study, supporting its use as a prophylactic therapy for HAE, researchers say.Reuters Health Information (Source: Medscape Allergy Headlines)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AwOlRt
Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis
ConclusionsOur results suggest that FPP intake could attenuate JCP symptoms without change of systemic immune responses. (Source: World Allergy Organization Journal)
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Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis
ConclusionsOur results suggest that FPP intake could attenuate JCP symptoms without change of systemic immune responses. (Source: World Allergy Organization Journal)
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Calcinosis in Dermatomyositis and Systemic Sclerosis: Lessons Learned from Observational Cohort Studies
Date: Thursday, 12 13, 2018; Speaker: Lorinda Chung, MD, MS, Associate Professor of Medicine (Immunology and Rheumatology) and Dermatology, Stanford University; Building: Building 10 (Clinical Center) (Source: NIH Calendar of Events)
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Daniel Pallin, MD, MPH - Emergency Medicine and Immuno-Oncology Intersect: Recognizing and Managing Cancer Immunotherapy –Related Adverse Effects in the Emergency Department
Emergency Medicine and Immuno-Oncology Intersect: Recognizing and Managing Cancer Immunotherapy–Related Adverse Effects in the Emergency Department (Source: PeerView CME/CE Audio Podcast - Immunology)
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Calcinosis in Dermatomyositis and Systemic Sclerosis: Lessons Learned from Observational Cohort Studies
Date: Thursday, 12 13, 2018; Speaker: Lorinda Chung, MD, MS, Associate Professor of Medicine (Immunology and Rheumatology) and Dermatology, Stanford University; Building: Building 10 (Clinical Center) (Source: NIH Calendar of Events)
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Daniel Pallin, MD, MPH - Emergency Medicine and Immuno-Oncology Intersect: Recognizing and Managing Cancer Immunotherapy –Related Adverse Effects in the Emergency Department
Emergency Medicine and Immuno-Oncology Intersect: Recognizing and Managing Cancer Immunotherapy–Related Adverse Effects in the Emergency Department (Source: PeerView CME/CE Audio Podcast - Immunology)
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The Outcome of Multidisciplinary Management of Carotid Body Tumors: Retrospective Cohort Study
Abstract
Background
Carotid body tumor (CBT) is a rare paraganglionic hyper-vascular tumor of the carotid body. The standard treatment for CBTs is surgery, but it involves risk. The study is aimed to assess the CBTs and evaluate the outcome of multidisciplinary management.
Materials and Methods
A retrospective cohort study included patients with CBTs who were managed by surgical excision between May 2006 and April 2018. A multidisciplinary team was established to excise the tumor completely with minimal neurovascular compromise.
Results
The study comprised of 32 patients in the age group of 23–65 years. The main presentation was a unilateral painless neck mass. Six cases (18.75%) were Shamblin I, 10 (31.25%) Shamblin II and 16 (50%) Shamblin III. Complete excision was performed for all cases. Ligation of the external carotid artery was done in 15 cases (46.88%) and repair of the internal carotid artery in 6 (18.75%). Postoperative cranial nerve complications occurred in six patients (18.75%): four transient hypoglossal pareses and two hoarseness of voice. Histopathologically, one case (3.125%) was malignant. No recurrence was detected through the follow-up period.
Conclusion
A multidisciplinary approach is essential for management of CBTs. Early diagnosis and surgical resection minimize morbidity and carry good surgical outcome.
Trial Registration Number
ChiCTR1800018722 (Agency: Chinese Clinical Trial Registry).
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The Outcome of Multidisciplinary Management of Carotid Body Tumors: Retrospective Cohort Study
Abstract
Background
Carotid body tumor (CBT) is a rare paraganglionic hyper-vascular tumor of the carotid body. The standard treatment for CBTs is surgery, but it involves risk. The study is aimed to assess the CBTs and evaluate the outcome of multidisciplinary management.
Materials and Methods
A retrospective cohort study included patients with CBTs who were managed by surgical excision between May 2006 and April 2018. A multidisciplinary team was established to excise the tumor completely with minimal neurovascular compromise.
Results
The study comprised of 32 patients in the age group of 23–65 years. The main presentation was a unilateral painless neck mass. Six cases (18.75%) were Shamblin I, 10 (31.25%) Shamblin II and 16 (50%) Shamblin III. Complete excision was performed for all cases. Ligation of the external carotid artery was done in 15 cases (46.88%) and repair of the internal carotid artery in 6 (18.75%). Postoperative cranial nerve complications occurred in six patients (18.75%): four transient hypoglossal pareses and two hoarseness of voice. Histopathologically, one case (3.125%) was malignant. No recurrence was detected through the follow-up period.
Conclusion
A multidisciplinary approach is essential for management of CBTs. Early diagnosis and surgical resection minimize morbidity and carry good surgical outcome.
Trial Registration Number
ChiCTR1800018722 (Agency: Chinese Clinical Trial Registry).
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Tampa Bay Buccaneer Shines Light on Meniere’s Disease
Tampa Bay Buccaneer Shines Light on Meniere's Disease
Elmhurst, IL, December 3, 2018—More than 500 NFL players wore custom-designed cleats in Week 13 for the #MyCauseMyCleats campaign. Tampa Bay Buccaneer Mike Leidtke chose to highlight the American Hearing Research Foundation (AHRF) for its work with Meniere's disease research. He explained this cause matters to him because his wife Noelle is dealing with Meniere's disease symptoms of vertigo and hearing loss. His cleats honor her as well.
An estimated 615,000 people in the United States suffer with Meniere's disease, which becomes more common with age. Most people with Meniere's disease are over 40. Currently, there is no known cure, but evidence-based therapies and treatments can help people better manage the symptoms, which can include ringing and pressure in the ears, along with fluctuating hearing loss, extreme dizziness, and associated nausea, falls, anxiety and/or depression.
"Meniere's disease can have a tremendous impact on everyday life," says President of AHRF, Alan Micco, MD. "We're very grateful that Mike Leidtke chose to step up and raise awareness about Meniere's challenges. At AHRF, we're committed to investing in research to better understand Meniere's disease and other hearing and balance disorders of the inner ear. Our ultimate goal is to identify treatments that will make a difference."
About AHRF
AHRF is a nonprofit organization that has been making new discoveries possible for more than 60 years by funding novel research to better understand and overcome hearing and balance disorders of the inner ear. Since 2010, the organization has funded 66 projects with more than $1.4 million in research grants.
Each year, AHRF offers a $25,000 grant for Meniere's disease research. In 2018, AHRF awarded a grant to Anna Lysakowski, PhD, at the University of Illinois at Chicago, who is a leader in the fields of neuroscience and anatomy. Lysakowski and her team are investigating genetic markers and antibodies of familial Meniere's disease, with the hope of creating human cellular models to test treatments in the future.
For more information on AHRF, visit www.American-Hearing.org. Donations for research funding can be made online.
Follow AHRF on Twitter. Like AHRF on Facebook. Sign up for newsletter updates on the AHRF homepage.
About #MyCauseMyCleats
As part of the collaboration between the NFL and players, in Week 13 players represent hundreds of charitable organizations through custom-designed cleats. Each pair of cleats tells a story. Players use their cleats to raise awareness about health issues, diseases, as well as social justice and equality causes.
Players have the opportunity to raise money for their cause by auctioning their cleats off at NFL Auction; 100 percent of money raised is donated to the player's charities. Fans may bid on game-issued player cleats to help players raise funds for their chosen causes.
The post Tampa Bay Buccaneer Shines Light on Meniere's Disease appeared first on American Hearing Research Foundation.
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Relationship between vitamin D and chronic spontaneous urticaria: a systematic review
Abstract
Background
Vitamin D has been reported to be associated with many allergic diseases. There are a limited number of the studies of vitamin D supplementation in patients with chronic spontaneous urticaria (CSU). This study aims to study the relationship between vitamin D and CSU in terms of serum vitamin D levels, and the outcomes of vitamin D supplementation.
Methods
A literature search of electronic databases for all relevant articles published between 1966 and 2018 was performed. The systematic literature review was done following Preferred Reporting Items for Systematic Reviews and Meta-analysis recommendations.
Results
Seventeen eligible studies were included. Fourteen (1321 CSU cases and 6100 controls) were concerned with serum vitamin D levels in CSU patients. Twelve studies showed statistically significant lower serum vitamin D levels in CSU patients than the controls. Vitamin D deficiency was reported more commonly for CSU patients (34.3–89.7%) than controls (0.0–68.9%) in 6 studies. Seven studies concerned with vitamin D supplementation in CSU patients showed disease improvement after high-dosages of vitamin D supplementation.
Conclusion
CSU patients had significantly lower serum vitamin D levels than the controls in most studies. However, the results did not prove causation, and the mechanisms were not clearly explained. Despite the scarcity of available studies, this systematic review showed that a high dosage of vitamin D supplementation for 4–12 weeks might help to decrease the disease activity in some CSU patients. Well-designed randomized placebo-controlled studies are needed to determine the cut-off levels of vitamin D for supplementation and treatment outcomes.
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Tampa Bay Buccaneer Shines Light on Meniere’s Disease
Tampa Bay Buccaneer Shines Light on Meniere's Disease
Elmhurst, IL, December 3, 2018—More than 500 NFL players wore custom-designed cleats in Week 13 for the #MyCauseMyCleats campaign. Tampa Bay Buccaneer Mike Leidtke chose to highlight the American Hearing Research Foundation (AHRF) for its work with Meniere's disease research. He explained this cause matters to him because his wife Noelle is dealing with Meniere's disease symptoms of vertigo and hearing loss. His cleats honor her as well.
An estimated 615,000 people in the United States suffer with Meniere's disease, which becomes more common with age. Most people with Meniere's disease are over 40. Currently, there is no known cure, but evidence-based therapies and treatments can help people better manage the symptoms, which can include ringing and pressure in the ears, along with fluctuating hearing loss, extreme dizziness, and associated nausea, falls, anxiety and/or depression.
"Meniere's disease can have a tremendous impact on everyday life," says President of AHRF, Alan Micco, MD. "We're very grateful that Mike Leidtke chose to step up and raise awareness about Meniere's challenges. At AHRF, we're committed to investing in research to better understand Meniere's disease and other hearing and balance disorders of the inner ear. Our ultimate goal is to identify treatments that will make a difference."
About AHRF
AHRF is a nonprofit organization that has been making new discoveries possible for more than 60 years by funding novel research to better understand and overcome hearing and balance disorders of the inner ear. Since 2010, the organization has funded 66 projects with more than $1.4 million in research grants.
Each year, AHRF offers a $25,000 grant for Meniere's disease research. In 2018, AHRF awarded a grant to Anna Lysakowski, PhD, at the University of Illinois at Chicago, who is a leader in the fields of neuroscience and anatomy. Lysakowski and her team are investigating genetic markers and antibodies of familial Meniere's disease, with the hope of creating human cellular models to test treatments in the future.
For more information on AHRF, visit www.American-Hearing.org. Donations for research funding can be made online.
Follow AHRF on Twitter. Like AHRF on Facebook. Sign up for newsletter updates on the AHRF homepage.
About #MyCauseMyCleats
As part of the collaboration between the NFL and players, in Week 13 players represent hundreds of charitable organizations through custom-designed cleats. Each pair of cleats tells a story. Players use their cleats to raise awareness about health issues, diseases, as well as social justice and equality causes.
Players have the opportunity to raise money for their cause by auctioning their cleats off at NFL Auction; 100 percent of money raised is donated to the player's charities. Fans may bid on game-issued player cleats to help players raise funds for their chosen causes.
The post Tampa Bay Buccaneer Shines Light on Meniere's Disease appeared first on American Hearing Research Foundation.
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Relationship between vitamin D and chronic spontaneous urticaria: a systematic review
Abstract
Background
Vitamin D has been reported to be associated with many allergic diseases. There are a limited number of the studies of vitamin D supplementation in patients with chronic spontaneous urticaria (CSU). This study aims to study the relationship between vitamin D and CSU in terms of serum vitamin D levels, and the outcomes of vitamin D supplementation.
Methods
A literature search of electronic databases for all relevant articles published between 1966 and 2018 was performed. The systematic literature review was done following Preferred Reporting Items for Systematic Reviews and Meta-analysis recommendations.
Results
Seventeen eligible studies were included. Fourteen (1321 CSU cases and 6100 controls) were concerned with serum vitamin D levels in CSU patients. Twelve studies showed statistically significant lower serum vitamin D levels in CSU patients than the controls. Vitamin D deficiency was reported more commonly for CSU patients (34.3–89.7%) than controls (0.0–68.9%) in 6 studies. Seven studies concerned with vitamin D supplementation in CSU patients showed disease improvement after high-dosages of vitamin D supplementation.
Conclusion
CSU patients had significantly lower serum vitamin D levels than the controls in most studies. However, the results did not prove causation, and the mechanisms were not clearly explained. Despite the scarcity of available studies, this systematic review showed that a high dosage of vitamin D supplementation for 4–12 weeks might help to decrease the disease activity in some CSU patients. Well-designed randomized placebo-controlled studies are needed to determine the cut-off levels of vitamin D for supplementation and treatment outcomes.
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Mycotic Aneurysm of the Extracranial Internal Carotid Artery Following Otitis Media
Abstract
Mycotic aneurysm of the internal carotid artery following otomastoiditis can manifest as a nasopharyngeal mass. This is a very rarely described condition. The case of a patient diagnosed with a retropharyngeal mycotic aneurysm of the left internal carotid artery following otitis media, treated with exclusion of the mycotic aneurysm from the circulation and transnasal drainage. Infection of the mastoid can spread to the parapharyngeal space of the nasopharynx and damage the carotid artery wall, resulting in an infected aneurysm. There are no guidelines on how to surgically approach those aneurysms. An endoscopic transnasal approach can be beneficial.
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Mycotic Aneurysm of the Extracranial Internal Carotid Artery Following Otitis Media
Abstract
Mycotic aneurysm of the internal carotid artery following otomastoiditis can manifest as a nasopharyngeal mass. This is a very rarely described condition. The case of a patient diagnosed with a retropharyngeal mycotic aneurysm of the left internal carotid artery following otitis media, treated with exclusion of the mycotic aneurysm from the circulation and transnasal drainage. Infection of the mastoid can spread to the parapharyngeal space of the nasopharynx and damage the carotid artery wall, resulting in an infected aneurysm. There are no guidelines on how to surgically approach those aneurysms. An endoscopic transnasal approach can be beneficial.
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Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis
Abstract
Background
Japanese cedar pollinosis (JCP) is one of the most prevalent allergies in Japan. Within the past few decades, many food factors have been demonstrated to suppress symptoms of pollinosis and mast cell degranulation directly or indirectly. Herein, we conducted a study to clarify the anti-allergic potency of a fermented plant product (FPP) in JCP model mice.
Methods
Mice were administered FPP, 10-fold-diluted FPP, or saline every day for 40 days by oral gavage and sensitized with major Japanese cedar pollen allergens (SBP). The numbers of sneezes were counted for 5 minutes after SBP nasal challenge. We analyzed the SBP-specific immunoglobulin titers, serum concentration of mast cell protease 1, and cytokine production from splenocytes stimulated with SBP.
Results
The numbers of sneezes by the mice administered FPP were significantly suppressed compared to those administered saline. The 10-fold-diluted FPP also suppressed the number of sneezes compared to saline, although not significantly. Serum level of mast cell protease 1 tended to be suppressed in FPP-consumed mice compared to those in saline-treated mice. The SBP-specific immunoglobulin titers and cytokine production were comparable among the groups.
Conclusions
Our results suggest that FPP intake could attenuate JCP symptoms without change of systemic immune responses.
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Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis
Abstract
Background
Japanese cedar pollinosis (JCP) is one of the most prevalent allergies in Japan. Within the past few decades, many food factors have been demonstrated to suppress symptoms of pollinosis and mast cell degranulation directly or indirectly. Herein, we conducted a study to clarify the anti-allergic potency of a fermented plant product (FPP) in JCP model mice.
Methods
Mice were administered FPP, 10-fold-diluted FPP, or saline every day for 40 days by oral gavage and sensitized with major Japanese cedar pollen allergens (SBP). The numbers of sneezes were counted for 5 minutes after SBP nasal challenge. We analyzed the SBP-specific immunoglobulin titers, serum concentration of mast cell protease 1, and cytokine production from splenocytes stimulated with SBP.
Results
The numbers of sneezes by the mice administered FPP were significantly suppressed compared to those administered saline. The 10-fold-diluted FPP also suppressed the number of sneezes compared to saline, although not significantly. Serum level of mast cell protease 1 tended to be suppressed in FPP-consumed mice compared to those in saline-treated mice. The SBP-specific immunoglobulin titers and cytokine production were comparable among the groups.
Conclusions
Our results suggest that FPP intake could attenuate JCP symptoms without change of systemic immune responses.
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The Outcome of Multidisciplinary Management of Carotid Body Tumors: Retrospective Cohort Study
Abstract
Background
Carotid body tumor (CBT) is a rare paraganglionic hyper-vascular tumor of the carotid body. The standard treatment for CBTs is surgery, but it involves risk. The study is aimed to assess the CBTs and evaluate the outcome of multidisciplinary management.
Materials and Methods
A retrospective cohort study included patients with CBTs who were managed by surgical excision between May 2006 and April 2018. A multidisciplinary team was established to excise the tumor completely with minimal neurovascular compromise.
Results
The study comprised of 32 patients in the age group of 23–65 years. The main presentation was a unilateral painless neck mass. Six cases (18.75%) were Shamblin I, 10 (31.25%) Shamblin II and 16 (50%) Shamblin III. Complete excision was performed for all cases. Ligation of the external carotid artery was done in 15 cases (46.88%) and repair of the internal carotid artery in 6 (18.75%). Postoperative cranial nerve complications occurred in six patients (18.75%): four transient hypoglossal pareses and two hoarseness of voice. Histopathologically, one case (3.125%) was malignant. No recurrence was detected through the follow-up period.
Conclusion
A multidisciplinary approach is essential for management of CBTs. Early diagnosis and surgical resection minimize morbidity and carry good surgical outcome.
Trial Registration Number
ChiCTR1800018722 (Agency: Chinese Clinical Trial Registry).
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The Outcome of Multidisciplinary Management of Carotid Body Tumors: Retrospective Cohort Study
Abstract
Background
Carotid body tumor (CBT) is a rare paraganglionic hyper-vascular tumor of the carotid body. The standard treatment for CBTs is surgery, but it involves risk. The study is aimed to assess the CBTs and evaluate the outcome of multidisciplinary management.
Materials and Methods
A retrospective cohort study included patients with CBTs who were managed by surgical excision between May 2006 and April 2018. A multidisciplinary team was established to excise the tumor completely with minimal neurovascular compromise.
Results
The study comprised of 32 patients in the age group of 23–65 years. The main presentation was a unilateral painless neck mass. Six cases (18.75%) were Shamblin I, 10 (31.25%) Shamblin II and 16 (50%) Shamblin III. Complete excision was performed for all cases. Ligation of the external carotid artery was done in 15 cases (46.88%) and repair of the internal carotid artery in 6 (18.75%). Postoperative cranial nerve complications occurred in six patients (18.75%): four transient hypoglossal pareses and two hoarseness of voice. Histopathologically, one case (3.125%) was malignant. No recurrence was detected through the follow-up period.
Conclusion
A multidisciplinary approach is essential for management of CBTs. Early diagnosis and surgical resection minimize morbidity and carry good surgical outcome.
Trial Registration Number
ChiCTR1800018722 (Agency: Chinese Clinical Trial Registry).
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Interprofessional Group Addresses Unmet Community Feeding Need: Speech-language pathology, dietetics, psychology and physical therapy join forces to help children with eating difficulties.
(Source: The ASHA Leader Online)
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Three Students Win Ethics Essay Contest
Kaley Ervin, an undergraduate speech-language pathology student at Texas State University, received first place in ASHA 's 2018 Student Ethics Essay Award competition for "Overstatement of Qualifications: Misrepresentation in Clinical Practice." (Source: The ASHA Leader Online)
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Medicare: A Must When Treating Older Patients: Medicare patients cannot pay out-of-pocket for covered audiology and speech-language pathology services.
(Source: The ASHA Leader Online)
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October Issue Is All About … Me
I wanted to tell you that the October issue seemed to be published with me in mind! First, I sentthe "More Baby Talk" article to my daughter, who gave birth to my first grandchild, Lincoln, just two weeks ago. I said, "This is what happens when Grandma is a speech-language pathologist!" (Source: The ASHA Leader Online)
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A Legacy of Hearing Loss: Watching previous generations struggle with deafness led to a career in speech-language pathology for this family member.
(Source: The ASHA Leader Online)
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School-Based Members Name Early Intervention as Top IDEA Issue: About 60 to 70 percent of audiologists and SLPs also identify early childhood and funding as important issues.
In a recent survey, school-based audiologists and speech-language pathologists rated the importance of nine issues in relation to the Individuals With Disabilities Education Act (IDEA). Audiologists rated early intervention as "very important" most frequently, followed by connection with the Early Hearing Detection and Intervention (EHDI) program. SLPs also rated early intervention as "very important" most frequently, followed by funding. Ratings will be used to help inform ASHA's IDEA advocacy priorities in fut ure years. (Source: The ASHA Leader Online)
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ASHFoundation Awards More Than $600,000 in Funding: Grants include the first researcher-practitioner collaboration awards.
Researchers, students and clinical professionals received more than $600,000 in funding from the American Speech-Language-Hearing Foundation. Among this year 's awardees are the first recipients of the Researcher-Practitioner Collaboration Grant, a new program to encourage collaborative research studies to improve services for people with communication disorders. (Source: The ASHA Leader Online)
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Interprofessional Group Addresses Unmet Community Feeding Need: Speech-language pathology, dietetics, psychology and physical therapy join forces to help children with eating difficulties.
(Source: The ASHA Leader Online)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AMoi9i
Three Students Win Ethics Essay Contest
Kaley Ervin, an undergraduate speech-language pathology student at Texas State University, received first place in ASHA 's 2018 Student Ethics Essay Award competition for "Overstatement of Qualifications: Misrepresentation in Clinical Practice." (Source: The ASHA Leader Online)
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Medicare: A Must When Treating Older Patients: Medicare patients cannot pay out-of-pocket for covered audiology and speech-language pathology services.
(Source: The ASHA Leader Online)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AKRRYI
October Issue Is All About … Me
I wanted to tell you that the October issue seemed to be published with me in mind! First, I sentthe "More Baby Talk" article to my daughter, who gave birth to my first grandchild, Lincoln, just two weeks ago. I said, "This is what happens when Grandma is a speech-language pathologist!" (Source: The ASHA Leader Online)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Udd9Y2
A Legacy of Hearing Loss: Watching previous generations struggle with deafness led to a career in speech-language pathology for this family member.
(Source: The ASHA Leader Online)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ALszcZ
School-Based Members Name Early Intervention as Top IDEA Issue: About 60 to 70 percent of audiologists and SLPs also identify early childhood and funding as important issues.
In a recent survey, school-based audiologists and speech-language pathologists rated the importance of nine issues in relation to the Individuals With Disabilities Education Act (IDEA). Audiologists rated early intervention as "very important" most frequently, followed by connection with the Early Hearing Detection and Intervention (EHDI) program. SLPs also rated early intervention as "very important" most frequently, followed by funding. Ratings will be used to help inform ASHA's IDEA advocacy priorities in fut ure years. (Source: The ASHA Leader Online)
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ASHFoundation Awards More Than $600,000 in Funding: Grants include the first researcher-practitioner collaboration awards.
Researchers, students and clinical professionals received more than $600,000 in funding from the American Speech-Language-Hearing Foundation. Among this year 's awardees are the first recipients of the Researcher-Practitioner Collaboration Grant, a new program to encourage collaborative research studies to improve services for people with communication disorders. (Source: The ASHA Leader Online)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Medication related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab- a review
The link between medication related osteonecrosis of the jaw (MRONJ) and bone modulating therapies such as bisphosphonates and denosumab is well established and the number of reported cases is increasing. The development of novel medications in cancer therapy, autoimmune and bone conditions has led to further cases of MRONJ being reported. However, in addition to this group of medications there are increasingly new agents in cancer therapy, such as anti-angiogenics agents that have now also been implicated in the development of MRONJ.
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Genetic alteration of Exon 5 of PTEN gene in Indian subjects with ameloblastoma
PI3K/Akt/mTOR pathway is one of the signalling pathways that are associated with the pathogenesis of ameloblastoma. Phosphatase and tensin homolog (PTEN) controls cell migration and proliferation. It monitors the level of the Akt and maintains cellular integrity. The present study was aimed to study the genetic alteration of Exon 5 of PTEN gene in Indian subjects with ameloblastoma.
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Salivary Gland Anlage Tumor: Molecular Profiling Sheds Light on a Morphologic Question
: The salivary gland anlage tumor (SGAT), previously described as a squamous proliferative lesion or "congenital pleomorphic adenoma," is a rare, benign entity that presents within the first months of life. It occurs almost exclusively in the nasopharynx or posterior nasal cavity, and demonstrates a biphasic composition of epithelial and mesenchymal elements. Although the clinical and histologic features of SGAT are well described, its etiology remains poorly understood. SGAT is currently considered a hamartoma rather than a neoplasm, partly due to its benign behavior and lack of reported recurrence following treatment.
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There is strength in numbers: A call to develop new collaborations
When I was a naïve undergraduate science student reading journals such as Cell and Nature, I was intrigued by how multiple research papers focused on similar topics "coincidentally" ended up being published within the same monthly journal issues, and oftentimes in sequence. It wasn't until years later that I had my "aha moment", and this was only after understanding the process of scientific publication through my participation as an Oral Pathology Section Editorial Board member of Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology (OOOO).
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PhLkKq
Medication related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab- a review
The link between medication related osteonecrosis of the jaw (MRONJ) and bone modulating therapies such as bisphosphonates and denosumab is well established and the number of reported cases is increasing. The development of novel medications in cancer therapy, autoimmune and bone conditions has led to further cases of MRONJ being reported. However, in addition to this group of medications there are increasingly new agents in cancer therapy, such as anti-angiogenics agents that have now also been implicated in the development of MRONJ.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zE1DfC
Genetic alteration of Exon 5 of PTEN gene in Indian subjects with ameloblastoma
PI3K/Akt/mTOR pathway is one of the signalling pathways that are associated with the pathogenesis of ameloblastoma. Phosphatase and tensin homolog (PTEN) controls cell migration and proliferation. It monitors the level of the Akt and maintains cellular integrity. The present study was aimed to study the genetic alteration of Exon 5 of PTEN gene in Indian subjects with ameloblastoma.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PexSa4
Salivary Gland Anlage Tumor: Molecular Profiling Sheds Light on a Morphologic Question
: The salivary gland anlage tumor (SGAT), previously described as a squamous proliferative lesion or "congenital pleomorphic adenoma," is a rare, benign entity that presents within the first months of life. It occurs almost exclusively in the nasopharynx or posterior nasal cavity, and demonstrates a biphasic composition of epithelial and mesenchymal elements. Although the clinical and histologic features of SGAT are well described, its etiology remains poorly understood. SGAT is currently considered a hamartoma rather than a neoplasm, partly due to its benign behavior and lack of reported recurrence following treatment.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zG609T
There is strength in numbers: A call to develop new collaborations
When I was a naïve undergraduate science student reading journals such as Cell and Nature, I was intrigued by how multiple research papers focused on similar topics "coincidentally" ended up being published within the same monthly journal issues, and oftentimes in sequence. It wasn't until years later that I had my "aha moment", and this was only after understanding the process of scientific publication through my participation as an Oral Pathology Section Editorial Board member of Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology (OOOO).
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Discussion of Paper Entitled “The Relation Between the Lower Lateral Cartilages and the Function of the External Nasal Valve”
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Discussion of Paper Entitled “The Relation Between the Lower Lateral Cartilages and the Function of the External Nasal Valve”
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Discussion of Paper Entitled “The Relation Between the Lower Lateral Cartilages and the Function of the External Nasal Valve”
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No change in the teaching of oral and maxillofacial surgery to medical students
We read with interest the recent paper by Hamid et al.1 We commend them for publishing an excellent paper that further highlights the lack of teaching about oral and maxillofacial surgery (OMFS) and lack of awareness of the specialty among medical students.2 Their findings echo our own, as we showed that 72% (183/253) of English medical students and 85% (318/374) of Irish medical students3 had no exposure to it. Several years on, it seems that this has remained a trend, with 89% (178/200) of students1 having had no clinical exposure.
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Oncocytic cystadenoma and oncocytic cysts of the parotid gland occurring synchronously with a pleomorphic adenoma
Synchronous tumours that arise ipsilaterally in the parotid gland are rare. We describe what is to our knowledge the first report of both oncocytic cysts and an oncocytic cystadenoma adjacent to a pleomorphic adenoma of the parotid gland.
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Treatment of a calcifying epithelial odontogenic tumour with tube decompression: a case report
Conservative treatment of odontogenic tumours with decompression or marsupialisation is not common, but can be done successfully in those with a cystic pattern. We present a calcifying epithelial odontogenic tumour that was treated by tube decompression and subsequent enucleation.
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Discussion of Paper Entitled “The Relation Between the Lower Lateral Cartilages and the Function of the External Nasal Valve”
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zGg1Un
No change in the teaching of oral and maxillofacial surgery to medical students
We read with interest the recent paper by Hamid et al.1 We commend them for publishing an excellent paper that further highlights the lack of teaching about oral and maxillofacial surgery (OMFS) and lack of awareness of the specialty among medical students.2 Their findings echo our own, as we showed that 72% (183/253) of English medical students and 85% (318/374) of Irish medical students3 had no exposure to it. Several years on, it seems that this has remained a trend, with 89% (178/200) of students1 having had no clinical exposure.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BQuO0t
Oncocytic cystadenoma and oncocytic cysts of the parotid gland occurring synchronously with a pleomorphic adenoma
Synchronous tumours that arise ipsilaterally in the parotid gland are rare. We describe what is to our knowledge the first report of both oncocytic cysts and an oncocytic cystadenoma adjacent to a pleomorphic adenoma of the parotid gland.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KSzWUq
Treatment of a calcifying epithelial odontogenic tumour with tube decompression: a case report
Conservative treatment of odontogenic tumours with decompression or marsupialisation is not common, but can be done successfully in those with a cystic pattern. We present a calcifying epithelial odontogenic tumour that was treated by tube decompression and subsequent enucleation.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BPOCkv
The association between long working hours and work-related musculoskeletal symptoms of Korean wage workers: data from the fourth Korean working conditions survey (a cross-sectional study)
It has been reported that long working hours are hazardous to the workers' health. Especially, work-related musculoskeletal disorders (WMSDs) have been considered as one of the significant health issues in wor...
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The association between long working hours and work-related musculoskeletal symptoms of Korean wage workers: data from the fourth Korean working conditions survey (a cross-sectional study)
It has been reported that long working hours are hazardous to the workers' health. Especially, work-related musculoskeletal disorders (WMSDs) have been considered as one of the significant health issues in wor...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RCbjyd
GSE123241 Single cell RNA-Seq reveals Fgf signaling dynamics during sensory hair cell regeneration
Contributors : Daniel C Diaz ; Sungmin Baek ; Helena Boldt ; Anoja Perera ; Kate Hall ; Allison Peak ; Jeffrey S Haug ; Tatjana PiotrowskiSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioLoss of sensory hair cells leads to deafness and balance deficiencies. In contrast to mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly characterized, proliferating support cells. Equally ill-defined is the gene regulatory network underlying the progression of support cells to cycling hair cell progenitors and differentiated hair cells. We used single-cell RNA-Sequencing (scRNA-Seq) of lateral line sensory organs and uncovered five different support cell types, including quiescent and activated stem cells. In silico ordering of suppo...
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GSE123241 Single cell RNA-Seq reveals Fgf signaling dynamics during sensory hair cell regeneration
Contributors : Daniel C Diaz ; Sungmin Baek ; Helena Boldt ; Anoja Perera ; Kate Hall ; Allison Peak ; Jeffrey S Haug ; Tatjana PiotrowskiSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioLoss of sensory hair cells leads to deafness and balance deficiencies. In contrast to mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly characterized, proliferating support cells. Equally ill-defined is the gene regulatory network underlying the progression of support cells to cycling hair cell progenitors and differentiated hair cells. We used single-cell RNA-Sequencing (scRNA-Seq) of lateral line sensory organs and uncovered five different support cell types, including quiescent and activated stem cells. In silico ordering of suppo...
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November 2018 Briefing - Allergy
Here are what the editors at HealthDay consider to be the most important developments in Allergy for November 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are... (Source: Drugs.com - Pharma News)
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Does She Have SCID?
Discussion Severe-combined immunodefiency (SCID) is actually a group of inherited disorders with an absence or dysfunction of T, B and NK cells that results in severe dysfunction of the immune system. SCID is a primary immunodeficiency. SCID was thought to be a rare disorder but with the advent of neonatal screening the incidence in the US general population is estimated at ~1 in 58,000 live births, but with numbers higher or lower depending on the specific population. Patients often have failure to thrive, oral candidiasis, and diarrhea as infants as well as a variety of infectious diseases. They can also have interstitial lung disease due to Pneumocystis jiroveci or graft-vs-host disease because of maternal lymphocyte engraphment. Without treatment to reconstitute the immune system, pa...
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November 2018 Briefing - Allergy
Here are what the editors at HealthDay consider to be the most important developments in Allergy for November 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are... (Source: Drugs.com - Pharma News)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Does She Have SCID?
Discussion Severe-combined immunodefiency (SCID) is actually a group of inherited disorders with an absence or dysfunction of T, B and NK cells that results in severe dysfunction of the immune system. SCID is a primary immunodeficiency. SCID was thought to be a rare disorder but with the advent of neonatal screening the incidence in the US general population is estimated at ~1 in 58,000 live births, but with numbers higher or lower depending on the specific population. Patients often have failure to thrive, oral candidiasis, and diarrhea as infants as well as a variety of infectious diseases. They can also have interstitial lung disease due to Pneumocystis jiroveci or graft-vs-host disease because of maternal lymphocyte engraphment. Without treatment to reconstitute the immune system, pa...
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Exporting Diabetic Retinopathy Images from VA VistA Imaging for Research
Abstract
The US Department of Veterans Affairs has been acquiring store and forward digital diabetic retinopathy surveillance retinal fundus images for remote reading since 2007. There are 900+ retinal cameras at 756 acquisition sites. These images are manually read remotely at 134 sites. A total of 2.1 million studies have been performed in the teleretinal imaging program. The human workload for reading images is rapidly growing. It would be ideal to develop an automated computer algorithm that detects multiple eye diseases as this would help standardize interpretations and improve efficiency of the image readers. Deep learning algorithms for detection of diabetic retinopathy in retinal fundus photographs have been developed and there are needs for additional image data to validate this work. To further this research, the Atlanta VA Health Care System (VAHCS) has extracted 112,000 DICOM diabetic retinopathy surveillance images (13,000 studies) that can be subsequently used for the validation of automated algorithms. An extensive amount of associated clinical information was added to the DICOM header of each exported image to facilitate correlation of the image with the patient's medical condition. The clinical information was saved as a JSON object and stored in a single Unlimited Text (VR = UT) DICOM data element. This paper describes the methodology used for this project and the results of applying this methodology.
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Safety of Lipoabdominoplasty Versus Abdominoplasty: A Systematic Review and Meta-analysis
Abstract
Background
Lipoabdominoplasty is a powerful operation to maintain a youthful physique for aging people, improve body contouring, and remove excess skin caused by massive weight loss. Nonetheless, it is controversial to combine abdominoplasty and liposuction because of the potential for vascular damage of the abdominal flap and increased complications. The purpose of this article was to determine the complication rates of lipoabdominoplasty compared with traditional abdominoplasty.
Methods
PubMed, EMBASE, and Cochrane databases were searched through July of 2018. Study results were analyzed utilizing a fixed random effects model. The outcomes were expressed as relative risk (RR) and 95% confidence interval. Subgroup analyses were conducted based on complications.
Results
Overall, 17 trials enrolling 14,061 adult patients were searched. Of these patients, 577 (4.1%) developed seroma; 113 (0.8%) experienced hematoma; 783 (5.6%) experienced wound infection, dehiscence, or fat necrosis; 35 (0.2%) developed deep venous thrombosis; and 110 (0.7%) experienced scar deformity. A forest plot revealed fewer complications in the lipoabdominoplasty group than in the traditional abdominoplasty group (RR = 0.85; 95% CI 0.74–0.97; p = 0.017). Subgroup analysis showed that the lipoabdominoplasty group had a lower incidence of hematoma (RR = 0.56; 95% CI 0.36–0.86; p = 0.009) and seroma (RR = 0.69; 95% CI 0.57–0.85; p = 0.000).
Conclusions
Lipoabdominoplasty is a valuable tool to perfect body shape. This meta-analysis showed no evidence that it was associated with higher rates of complications.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RvE7s0
Exporting Diabetic Retinopathy Images from VA VistA Imaging for Research
Abstract
The US Department of Veterans Affairs has been acquiring store and forward digital diabetic retinopathy surveillance retinal fundus images for remote reading since 2007. There are 900+ retinal cameras at 756 acquisition sites. These images are manually read remotely at 134 sites. A total of 2.1 million studies have been performed in the teleretinal imaging program. The human workload for reading images is rapidly growing. It would be ideal to develop an automated computer algorithm that detects multiple eye diseases as this would help standardize interpretations and improve efficiency of the image readers. Deep learning algorithms for detection of diabetic retinopathy in retinal fundus photographs have been developed and there are needs for additional image data to validate this work. To further this research, the Atlanta VA Health Care System (VAHCS) has extracted 112,000 DICOM diabetic retinopathy surveillance images (13,000 studies) that can be subsequently used for the validation of automated algorithms. An extensive amount of associated clinical information was added to the DICOM header of each exported image to facilitate correlation of the image with the patient's medical condition. The clinical information was saved as a JSON object and stored in a single Unlimited Text (VR = UT) DICOM data element. This paper describes the methodology used for this project and the results of applying this methodology.
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Safety of Lipoabdominoplasty Versus Abdominoplasty: A Systematic Review and Meta-analysis
Abstract
Background
Lipoabdominoplasty is a powerful operation to maintain a youthful physique for aging people, improve body contouring, and remove excess skin caused by massive weight loss. Nonetheless, it is controversial to combine abdominoplasty and liposuction because of the potential for vascular damage of the abdominal flap and increased complications. The purpose of this article was to determine the complication rates of lipoabdominoplasty compared with traditional abdominoplasty.
Methods
PubMed, EMBASE, and Cochrane databases were searched through July of 2018. Study results were analyzed utilizing a fixed random effects model. The outcomes were expressed as relative risk (RR) and 95% confidence interval. Subgroup analyses were conducted based on complications.
Results
Overall, 17 trials enrolling 14,061 adult patients were searched. Of these patients, 577 (4.1%) developed seroma; 113 (0.8%) experienced hematoma; 783 (5.6%) experienced wound infection, dehiscence, or fat necrosis; 35 (0.2%) developed deep venous thrombosis; and 110 (0.7%) experienced scar deformity. A forest plot revealed fewer complications in the lipoabdominoplasty group than in the traditional abdominoplasty group (RR = 0.85; 95% CI 0.74–0.97; p = 0.017). Subgroup analysis showed that the lipoabdominoplasty group had a lower incidence of hematoma (RR = 0.56; 95% CI 0.36–0.86; p = 0.009) and seroma (RR = 0.69; 95% CI 0.57–0.85; p = 0.000).
Conclusions
Lipoabdominoplasty is a valuable tool to perfect body shape. This meta-analysis showed no evidence that it was associated with higher rates of complications.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RvE7s0
Omalizumab in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA): single-center experience in 18 cases
ConclusionsOmalizumab improved asthma control in some patients with EGPA with uncontrolled asthma by reducing asthma exacerbations and oral steroid requirement. However, more data are needed before recommending widespread use of omalizumab in patients with EGPA. (Source: World Allergy Organization Journal)
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Omalizumab in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA): single-center experience in 18 cases
ConclusionsOmalizumab improved asthma control in some patients with EGPA with uncontrolled asthma by reducing asthma exacerbations and oral steroid requirement. However, more data are needed before recommending widespread use of omalizumab in patients with EGPA. (Source: World Allergy Organization Journal)
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November 2018 Briefing - Allergy
Here are what the editors at HealthDay consider to be the most important developments in Allergy for November 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are... (Source: Drugs.com - Pharma News)
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Does She Have SCID?
Discussion Severe-combined immunodefiency (SCID) is actually a group of inherited disorders with an absence or dysfunction of T, B and NK cells that results in severe dysfunction of the immune system. SCID is a primary immunodeficiency. SCID was thought to be a rare disorder but with the advent of neonatal screening the incidence in the US general population is estimated at ~1 in 58,000 live births, but with numbers higher or lower depending on the specific population. Patients often have failure to thrive, oral candidiasis, and diarrhea as infants as well as a variety of infectious diseases. They can also have interstitial lung disease due to Pneumocystis jiroveci or graft-vs-host disease because of maternal lymphocyte engraphment. Without treatment to reconstitute the immune system, pa...
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Safety of Lipoabdominoplasty Versus Abdominoplasty: A Systematic Review and Meta-analysis
Abstract
Background
Lipoabdominoplasty is a powerful operation to maintain a youthful physique for aging people, improve body contouring, and remove excess skin caused by massive weight loss. Nonetheless, it is controversial to combine abdominoplasty and liposuction because of the potential for vascular damage of the abdominal flap and increased complications. The purpose of this article was to determine the complication rates of lipoabdominoplasty compared with traditional abdominoplasty.
Methods
PubMed, EMBASE, and Cochrane databases were searched through July of 2018. Study results were analyzed utilizing a fixed random effects model. The outcomes were expressed as relative risk (RR) and 95% confidence interval. Subgroup analyses were conducted based on complications.
Results
Overall, 17 trials enrolling 14,061 adult patients were searched. Of these patients, 577 (4.1%) developed seroma; 113 (0.8%) experienced hematoma; 783 (5.6%) experienced wound infection, dehiscence, or fat necrosis; 35 (0.2%) developed deep venous thrombosis; and 110 (0.7%) experienced scar deformity. A forest plot revealed fewer complications in the lipoabdominoplasty group than in the traditional abdominoplasty group (RR = 0.85; 95% CI 0.74–0.97; p = 0.017). Subgroup analysis showed that the lipoabdominoplasty group had a lower incidence of hematoma (RR = 0.56; 95% CI 0.36–0.86; p = 0.009) and seroma (RR = 0.69; 95% CI 0.57–0.85; p = 0.000).
Conclusions
Lipoabdominoplasty is a valuable tool to perfect body shape. This meta-analysis showed no evidence that it was associated with higher rates of complications.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RvE7s0
November 2018 Briefing - Allergy
Here are what the editors at HealthDay consider to be the most important developments in Allergy for November 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are... (Source: Drugs.com - Pharma News)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RwLYpf
Does She Have SCID?
Discussion Severe-combined immunodefiency (SCID) is actually a group of inherited disorders with an absence or dysfunction of T, B and NK cells that results in severe dysfunction of the immune system. SCID is a primary immunodeficiency. SCID was thought to be a rare disorder but with the advent of neonatal screening the incidence in the US general population is estimated at ~1 in 58,000 live births, but with numbers higher or lower depending on the specific population. Patients often have failure to thrive, oral candidiasis, and diarrhea as infants as well as a variety of infectious diseases. They can also have interstitial lung disease due to Pneumocystis jiroveci or graft-vs-host disease because of maternal lymphocyte engraphment. Without treatment to reconstitute the immune system, pa...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QfsetO
Safety of Lipoabdominoplasty Versus Abdominoplasty: A Systematic Review and Meta-analysis
Abstract
Background
Lipoabdominoplasty is a powerful operation to maintain a youthful physique for aging people, improve body contouring, and remove excess skin caused by massive weight loss. Nonetheless, it is controversial to combine abdominoplasty and liposuction because of the potential for vascular damage of the abdominal flap and increased complications. The purpose of this article was to determine the complication rates of lipoabdominoplasty compared with traditional abdominoplasty.
Methods
PubMed, EMBASE, and Cochrane databases were searched through July of 2018. Study results were analyzed utilizing a fixed random effects model. The outcomes were expressed as relative risk (RR) and 95% confidence interval. Subgroup analyses were conducted based on complications.
Results
Overall, 17 trials enrolling 14,061 adult patients were searched. Of these patients, 577 (4.1%) developed seroma; 113 (0.8%) experienced hematoma; 783 (5.6%) experienced wound infection, dehiscence, or fat necrosis; 35 (0.2%) developed deep venous thrombosis; and 110 (0.7%) experienced scar deformity. A forest plot revealed fewer complications in the lipoabdominoplasty group than in the traditional abdominoplasty group (RR = 0.85; 95% CI 0.74–0.97; p = 0.017). Subgroup analysis showed that the lipoabdominoplasty group had a lower incidence of hematoma (RR = 0.56; 95% CI 0.36–0.86; p = 0.009) and seroma (RR = 0.69; 95% CI 0.57–0.85; p = 0.000).
Conclusions
Lipoabdominoplasty is a valuable tool to perfect body shape. This meta-analysis showed no evidence that it was associated with higher rates of complications.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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Alfred Mann Foundation chairman looks outward to extend founder ’ s legacy
When medtech pioneer Alfred Mann died in February 2016, he left behind a rich legacy of pure innovation and patient impact spanning the breadth of healthcare, from cardiology to hearing impairment, blindness and diabetes that will improve the lives of patients for decades to come. Extending and advancing that legacy is now the mission of Dr. Robert Greenberg, who took over as the foundation's chairman in July. Speaking ahead of his appearance next week at MassDevice.com's DeviceTalks West event in Costa Mesa, Greenberg told us that he's looking to expand the foundation's reach into the early-stage medical device ecosystem. Don't miss Dr. Robert Greenberg's keynote appearance Dec. 12 at DeviceTalks West! "One of the recognitions that Al Mann had was that t...
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Incredible footage shows teenage girl SINGING through brain surgery to preserve her musical talent
Kira Laconetti, of Washington, became tone deaf due to musicogenic epilepsy. Surgeons performed an 'awake craniotomy' in order to identify and preserve the musical area of her brain. (Source: the Mail online | Health)
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Alfred Mann Foundation chairman looks outward to extend founder ’ s legacy
When medtech pioneer Alfred Mann died in February 2016, he left behind a rich legacy of pure innovation and patient impact spanning the breadth of healthcare, from cardiology to hearing impairment, blindness and diabetes that will improve the lives of patients for decades to come. Extending and advancing that legacy is now the mission of Dr. Robert Greenberg, who took over as the foundation's chairman in July. Speaking ahead of his appearance next week at MassDevice.com's DeviceTalks West event in Costa Mesa, Greenberg told us that he's looking to expand the foundation's reach into the early-stage medical device ecosystem. Don't miss Dr. Robert Greenberg's keynote appearance Dec. 12 at DeviceTalks West! "One of the recognitions that Al Mann had was that t...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FW7lyN
Incredible footage shows teenage girl SINGING through brain surgery to preserve her musical talent
Kira Laconetti, of Washington, became tone deaf due to musicogenic epilepsy. Surgeons performed an 'awake craniotomy' in order to identify and preserve the musical area of her brain. (Source: the Mail online | Health)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rkJ2Rc
Looking at a missing cochlea: cochlear aplasia or labyrinth ossification?
. (Source: Hearing, Balance and Communication)
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Cochlear implantation in patients afflicted with inner ear malformations – the Pécs experience
. (Source: Hearing, Balance and Communication)
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The role of the audiologist –phoniatrician in performing the dynamic endoscopic study of swallowing. Position statement of the Italian study group on dysphagia (GISD)*
. (Source: Hearing, Balance and Communication)
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Convolutional Neural Networks for the Detection and Measurement of Cerebral Aneurysms on Magnetic Resonance Angiography
Abstract
Aneurysm size correlates with rupture risk and is important for treatment planning. User annotation of aneurysm size is slow and tedious, particularly for large data sets. Geometric shortcuts to compute size have been shown to be inaccurate, particularly for nonstandard aneurysm geometries. To develop and train a convolutional neural network (CNN) to detect and measure cerebral aneurysms from magnetic resonance angiography (MRA) automatically and without geometric shortcuts. In step 1, a CNN based on the U-net architecture was trained on 250 MRA maximum intensity projection (MIP) images, then applied to a testing set. In step 2, the trained CNN was applied to a separate set of 14 basilar tip aneurysms for size prediction. Step 1—the CNN successfully identified aneurysms in 85/86 (98.8% of) testing set cases, with a receiver operating characteristic (ROC) area-under-the-curve of 0.87. Step 2—automated basilar tip aneurysm linear size differed from radiologist-traced aneurysm size on average by 2.01 mm, or 30%. The CNN aneurysm area differed from radiologist-derived area on average by 8.1 mm2 or 27%. CNN correctly predicted the area trend for the set of aneurysms. This approach is to our knowledge the first using CNNs to derive aneurysm size. In particular, we demonstrate the clinically pertinent application of computing maximal aneurysm one-dimensional size and two-dimensional area. We propose that future work can apply this to facilitate pre-treatment planning and possibly identify previously missed aneurysms in retrospective assessment.
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Looking at a missing cochlea: cochlear aplasia or labyrinth ossification?
. (Source: Hearing, Balance and Communication)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q8i6CS
Cochlear implantation in patients afflicted with inner ear malformations – the Pécs experience
. (Source: Hearing, Balance and Communication)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RxhnHY
The role of the audiologist –phoniatrician in performing the dynamic endoscopic study of swallowing. Position statement of the Italian study group on dysphagia (GISD)*
. (Source: Hearing, Balance and Communication)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q9zTtq
Convolutional Neural Networks for the Detection and Measurement of Cerebral Aneurysms on Magnetic Resonance Angiography
Abstract
Aneurysm size correlates with rupture risk and is important for treatment planning. User annotation of aneurysm size is slow and tedious, particularly for large data sets. Geometric shortcuts to compute size have been shown to be inaccurate, particularly for nonstandard aneurysm geometries. To develop and train a convolutional neural network (CNN) to detect and measure cerebral aneurysms from magnetic resonance angiography (MRA) automatically and without geometric shortcuts. In step 1, a CNN based on the U-net architecture was trained on 250 MRA maximum intensity projection (MIP) images, then applied to a testing set. In step 2, the trained CNN was applied to a separate set of 14 basilar tip aneurysms for size prediction. Step 1—the CNN successfully identified aneurysms in 85/86 (98.8% of) testing set cases, with a receiver operating characteristic (ROC) area-under-the-curve of 0.87. Step 2—automated basilar tip aneurysm linear size differed from radiologist-traced aneurysm size on average by 2.01 mm, or 30%. The CNN aneurysm area differed from radiologist-derived area on average by 8.1 mm2 or 27%. CNN correctly predicted the area trend for the set of aneurysms. This approach is to our knowledge the first using CNNs to derive aneurysm size. In particular, we demonstrate the clinically pertinent application of computing maximal aneurysm one-dimensional size and two-dimensional area. We propose that future work can apply this to facilitate pre-treatment planning and possibly identify previously missed aneurysms in retrospective assessment.
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Study: Immunotherapy better than chemotherapy for subtype of head and neck cancer
Date: November 30th, 2018 Source: Scienmag A randomized clinical trial involving 97 medical centers in 20 countries, including Moores Cancer Center […]
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Evaluation of Glandular Liposculpture as a Single Treatment for Grades I and II Gynecomastia
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Discussion: Treatment of Breast Animation Deformity in Implant-Based Reconstruction with Selective Nerve Ablation
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Correction to: Metrics of the Aesthetically Perfect Breast
Bishara Atiyeh's name was misspelled in this article. It appears correctly here.
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Quality of Life Gain After Septorhinoplasty: An Analysis of Health Utility and Cost Utility Values Associated with Septorhinoplasty
Abstract
Purpose
Septorhinoplasty is a common procedure performed in rhinology and facial plastic surgery. Despite this, the health benefits associated with the procedure remain controversial. In this study, a health utility assessment of patients undergoing septorhinoplasty was performed. Health gains associated with the procedure, and the cost at which they were acquired, were also determined.
Methods
Sixty-seven patients undergoing septorhinoplasty at a German tertiary-level hospital were included in the study. Study participants completed the Short Form 36 (SF-36) and satisfaction questionnaires before and 12 months after septorhinoplasty. The Short Form six-dimensional (SF-6D) instrument was used to acquire quality-adjusted life year (QALY) values from SF-36 responses, thus allowing estimation of pre- and post-operative health utilities. Health utility gains after septorhinoplasty were determined and combined with cost data to estimate cost per QALY gained.
Results
Patients undergoing septorhinoplasty reported mean pre-operative health utility values of 0.70 pre-operatively and 0.74 post-operatively resulting in health gains of 0.04 QALYs. Patients satisfied with their procedures had significant health utility gains, while dissatisfied patients did not experience any significant gains. The cost of septorhinoplasty to statutory health insurance was €3487.69. When compared to the baseline, the incremental utility ratio for septorhinoplasty was €94,797.30 per QALY gained.
Conclusions
This study successfully estimated the health utilities and gains associated with septorhinoplasty. The findings indicate that the procedure has associated health gains but at a high cost–utility ratio. These values provide a reference point for further much-needed economic evaluations.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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Study: Immunotherapy better than chemotherapy for subtype of head and neck cancer
Date: November 30th, 2018 Source: Scienmag A randomized clinical trial involving 97 medical centers in 20 countries, including Moores Cancer Center […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rhb2oL
Evaluation of Glandular Liposculpture as a Single Treatment for Grades I and II Gynecomastia
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J7ZMGp
Discussion: Treatment of Breast Animation Deformity in Implant-Based Reconstruction with Selective Nerve Ablation
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zFMjij
Correction to: Metrics of the Aesthetically Perfect Breast
Bishara Atiyeh's name was misspelled in this article. It appears correctly here.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zFMrOP
Quality of Life Gain After Septorhinoplasty: An Analysis of Health Utility and Cost Utility Values Associated with Septorhinoplasty
Abstract
Purpose
Septorhinoplasty is a common procedure performed in rhinology and facial plastic surgery. Despite this, the health benefits associated with the procedure remain controversial. In this study, a health utility assessment of patients undergoing septorhinoplasty was performed. Health gains associated with the procedure, and the cost at which they were acquired, were also determined.
Methods
Sixty-seven patients undergoing septorhinoplasty at a German tertiary-level hospital were included in the study. Study participants completed the Short Form 36 (SF-36) and satisfaction questionnaires before and 12 months after septorhinoplasty. The Short Form six-dimensional (SF-6D) instrument was used to acquire quality-adjusted life year (QALY) values from SF-36 responses, thus allowing estimation of pre- and post-operative health utilities. Health utility gains after septorhinoplasty were determined and combined with cost data to estimate cost per QALY gained.
Results
Patients undergoing septorhinoplasty reported mean pre-operative health utility values of 0.70 pre-operatively and 0.74 post-operatively resulting in health gains of 0.04 QALYs. Patients satisfied with their procedures had significant health utility gains, while dissatisfied patients did not experience any significant gains. The cost of septorhinoplasty to statutory health insurance was €3487.69. When compared to the baseline, the incremental utility ratio for septorhinoplasty was €94,797.30 per QALY gained.
Conclusions
This study successfully estimated the health utilities and gains associated with septorhinoplasty. The findings indicate that the procedure has associated health gains but at a high cost–utility ratio. These values provide a reference point for further much-needed economic evaluations.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases
In addition to allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FWQaxh
Omalizumab in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA): single-center experience in 18 cases
Data are limited regarding the effectiveness of omalizumab in patients with eosinophilic granulomatosis with polyangiitis (EGPA). Our aim was to evaluate the clinical and functional effectiveness of omalizumab...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zEu7Wx
Impact of a digital health intervention on asthma resource utilization
Digital health interventions have been associated with reduced rescue inhaler use and improved controller medication adherence. This quality improvement project assessed the benefit of these interventions on a...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PhZj2A
Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases
In addition to allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FWQaxh
Omalizumab in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA): single-center experience in 18 cases
Data are limited regarding the effectiveness of omalizumab in patients with eosinophilic granulomatosis with polyangiitis (EGPA). Our aim was to evaluate the clinical and functional effectiveness of omalizumab...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zEu7Wx
Impact of a digital health intervention on asthma resource utilization
Digital health interventions have been associated with reduced rescue inhaler use and improved controller medication adherence. This quality improvement project assessed the benefit of these interventions on a...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PhZj2A
Alfred Mann Foundation chairman looks outward to extend founder ’ s legacy
When medtech pioneer Alfred Mann died in February 2016, he left behind a rich legacy of pure innovation and patient impact spanning the breadth of healthcare, from cardiology to hearing impairment, blindness and diabetes that will improve the lives of patients for decades to come. Extending and advancing that legacy is now the mission of Dr. Robert Greenberg, who took over as the foundation's chairman in July. Speaking ahead of his appearance next week at MassDevice.com's DeviceTalks West event in Costa Mesa, Greenberg told us that he's looking to expand the foundation's reach into the early-stage medical device ecosystem. Don't miss Dr. Robert Greenberg's keynote appearance Dec. 12 at DeviceTalks West! "One of the recognitions that Al Mann had was that t...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FW7lyN
Incredible footage shows teenage girl SINGING through brain surgery to preserve her musical talent
Kira Laconetti, of Washington, became tone deaf due to musicogenic epilepsy. Surgeons performed an 'awake craniotomy' in order to identify and preserve the musical area of her brain. (Source: the Mail online | Health)
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Alfred Mann Foundation chairman looks outward to extend founder ’ s legacy
When medtech pioneer Alfred Mann died in February 2016, he left behind a rich legacy of pure innovation and patient impact spanning the breadth of healthcare, from cardiology to hearing impairment, blindness and diabetes that will improve the lives of patients for decades to come. Extending and advancing that legacy is now the mission of Dr. Robert Greenberg, who took over as the foundation's chairman in July. Speaking ahead of his appearance next week at MassDevice.com's DeviceTalks West event in Costa Mesa, Greenberg told us that he's looking to expand the foundation's reach into the early-stage medical device ecosystem. Don't miss Dr. Robert Greenberg's keynote appearance Dec. 12 at DeviceTalks West! "One of the recognitions that Al Mann had was that t...
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Incredible footage shows teenage girl SINGING through brain surgery to preserve her musical talent
Kira Laconetti, of Washington, became tone deaf due to musicogenic epilepsy. Surgeons performed an 'awake craniotomy' in order to identify and preserve the musical area of her brain. (Source: the Mail online | Health)
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Evaluation of Glandular Liposculpture as a Single Treatment for Grades I and II Gynecomastia
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Discussion: Treatment of Breast Animation Deformity in Implant-Based Reconstruction with Selective Nerve Ablation
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Correction to: Metrics of the Aesthetically Perfect Breast
Bishara Atiyeh's name was misspelled in this article. It appears correctly here.
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Quality of Life Gain After Septorhinoplasty: An Analysis of Health Utility and Cost Utility Values Associated with Septorhinoplasty
Abstract
Purpose
Septorhinoplasty is a common procedure performed in rhinology and facial plastic surgery. Despite this, the health benefits associated with the procedure remain controversial. In this study, a health utility assessment of patients undergoing septorhinoplasty was performed. Health gains associated with the procedure, and the cost at which they were acquired, were also determined.
Methods
Sixty-seven patients undergoing septorhinoplasty at a German tertiary-level hospital were included in the study. Study participants completed the Short Form 36 (SF-36) and satisfaction questionnaires before and 12 months after septorhinoplasty. The Short Form six-dimensional (SF-6D) instrument was used to acquire quality-adjusted life year (QALY) values from SF-36 responses, thus allowing estimation of pre- and post-operative health utilities. Health utility gains after septorhinoplasty were determined and combined with cost data to estimate cost per QALY gained.
Results
Patients undergoing septorhinoplasty reported mean pre-operative health utility values of 0.70 pre-operatively and 0.74 post-operatively resulting in health gains of 0.04 QALYs. Patients satisfied with their procedures had significant health utility gains, while dissatisfied patients did not experience any significant gains. The cost of septorhinoplasty to statutory health insurance was €3487.69. When compared to the baseline, the incremental utility ratio for septorhinoplasty was €94,797.30 per QALY gained.
Conclusions
This study successfully estimated the health utilities and gains associated with septorhinoplasty. The findings indicate that the procedure has associated health gains but at a high cost–utility ratio. These values provide a reference point for further much-needed economic evaluations.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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