Why I Went to ASHA ’ s Advocacy Day and Plan to Go Back

Do you remember those cellular commercials that bombarded us with the catchphrase, "Can you hear me now?" Guess what? Over time, it worked. A number of people switched their phone service to the company … maybe not because of the catchphrase itself, but possibly because of the totality of the message, repeated time and time again. A simple and efficient message changed minds and perspectives. And we can do the same when it comes to advocating for our professions of audiology and speech-language pathology. I'm an audiologist and not a minister, so I don't need to preach to the choir regarding these issues, but please indulge me sharing my first experience participating in ASHA's annual Capitol Hill Advocacy Day. In March, I partnered with dozens of other ASHA members hea...

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Why I Went to ASHA ’ s Advocacy Day and Plan to Go Back

Do you remember those cellular commercials that bombarded us with the catchphrase, "Can you hear me now?" Guess what? Over time, it worked. A number of people switched their phone service to the company … maybe not because of the catchphrase itself, but possibly because of the totality of the message, repeated time and time again. A simple and efficient message changed minds and perspectives. And we can do the same when it comes to advocating for our professions of audiology and speech-language pathology. I'm an audiologist and not a minister, so I don't need to preach to the choir regarding these issues, but please indulge me sharing my first experience participating in ASHA's annual Capitol Hill Advocacy Day. In March, I partnered with dozens of other ASHA members hea...

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Pretibial Lymphoplasmacytic Plaque in Children: Case Report and Review of the Literature

Abstract: An 8-year-old girl presented with a persistent 5 × 2-cm violaceous doughy plaque on the left lower leg. Histologic examination revealed hyperkeratosis, variable but mild epidermal hyperplasia, and vacuolar interface changes with melanin pigment incontinence confined to the papillary dermis. A diagnosis of pretibial lymphoplasmacytic plaque in children was made. This report outlines the clinical characteristics of this entity and a review of other cases reported in the literature. Correspondence: David N. Adam, MD, FRCPC, DABD, 95 Bayly Street West Suite G -02, Ajax, ON L1S 7K8, Canada (e-mail: dnadam@gmail.com). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Acquired Dermal Melanocytosis Associated With Diffuse Systemic Sclerosis in a White Patient

Abstract: We report a case of a 65-year-old man who developed an asymptomatic bluish spot that affected the flank and left lumbar region with the onset 10 years prior. He had a history of diffuse systemic sclerosis with anti-Scl-70–positive antibodies. The appearance of the skin lesion coincided with the onset of his disease. The skin biopsy was consistent with the diagnosis of acquired dermal melanocytosis. The relationship between the appearance of acquired pigmented macules and spots and systemic sclerosis has been known for years, although it is an infrequent finding. Correspondence: Lidia Ossorio-García, MD, Department of Dermatology, Hospital Universitario Puerta del Mar, Ana de Viya Av, 21 Cadiz, Andalusia 11009, Spain (e-mail: lidia.osga@gmail.com). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Reflectance Confocal Microscopy Can Help the Dermatopathologist in the Diagnosis of Challenging Skin Lesions

Abstract: Despite the successful assignment of Current Procedural Terminology codes, there are barriers to incorporating in vivo reflectance confocal microscopy (RCM) into daily practice. Importantly, the dermatopathologist can play a key role in interpreting RCM images and can use these images to correlate with histopathology. Herein, we describe, using a case series, how RCM can be incorporated into the dermatopothalogist's practice. We also summarize the criteria for RCM diagnosis of common neoplasms. Correspondence: Jane M. Grant-Kels, MD, UCONN Dermatology Department, 21 South Road, Farmington, CT 06032 (e-mail: grant@uchc.edu). H. Rabinovitz and M. Oliviero have received honoraria in the past from Caliber, the company that produces RCM. J.M. Grant-Kels and H. Rabinovitz have also received equipment in the past from Caliber. There were no payments for conducting or publicizing this study. The remaining authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Alveolar Soft-Part Sarcoma of the Tongue

Abstract: Alveolar soft-part sarcoma is a rare neoplasm of unknown histogenesis that accounts for less than 1% of all soft-tissue sarcomas. The tumor is highly vascularized with small vascular spaces separating nests of cells, and from cytogenetic point of view, is characterized by chromosome rearrangement der(17)t(X:17)(p11:q25) that results in the ASPL-TFE3 translocation. It can occur at any age, but it is most common between 15 and 35 years of age. The prognosis is poor, despite the relatively slow growth of the tumor. We present here an atypical case of alveolar soft-part sarcoma in which the age of the patient, the location, and the histopathologic characteristics of the lesion represented a diagnostic challenge. Correspondence: Luis Requena, MD, Department of Dermatology, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, Spain (e-mail: lrequena@fjd.es). V. Alegría-Landa and V. Lora have contributed equally in the performance of this article. The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Reflectance Confocal Microscopy Can Help the Dermatopathologist in the Diagnosis of Challenging Skin Lesions

Abstract: Despite the successful assignment of Current Procedural Terminology codes, there are barriers to incorporating in vivo reflectance confocal microscopy (RCM) into daily practice. Importantly, the dermatopathologist can play a key role in interpreting RCM images and can use these images to correlate with histopathology. Herein, we describe, using a case series, how RCM can be incorporated into the dermatopothalogist's practice. We also summarize the criteria for RCM diagnosis of common neoplasms. Correspondence: Jane M. Grant-Kels, MD, UCONN Dermatology Department, 21 South Road, Farmington, CT 06032 (e-mail: grant@uchc.edu). H. Rabinovitz and M. Oliviero have received honoraria in the past from Caliber, the company that produces RCM. J.M. Grant-Kels and H. Rabinovitz have also received equipment in the past from Caliber. There were no payments for conducting or publicizing this study. The remaining authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Refractory Hand Dermatitis With Massive Thumb Enlargement

No abstract available

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What's in a name? Perhaps anxiety and overtreatment

What's in a name? Perhaps anxiety and overtreatment  Pharmacy NewsFull coverage

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Natural ways to treat thyroid disease

Natural ways to treat thyroid disease  WNDU-TVFull coverage

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HPV Vaccine May Reduce Risk Of Transmitting Devastating Throat Disease To Children

HPV Vaccine May Reduce Risk Of Transmitting Devastating Throat Disease To Children  ForbesFull coverage

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Copy Number Alteration Found to Be Associated with Cancer Mortality

Copy Number Alteration Found to Be Associated with Cancer Mortality  Genetic Engineering & Biotechnology NewsFull coverage

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FDA grants RET inhibitor breakthrough therapy designation for lung, thyroid cancers

FDA grants RET inhibitor breakthrough therapy designation for lung, thyroid cancers  HealioLOXO-292 Granted Breakthrough Therapy Designation for Lung and Thyroid Cancer  Curetoday.comFull coverage

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A second opinion on a cancer diagnosis, from the comforts of home — for a price

A second opinion on a cancer diagnosis, from the comforts of home — for a price  San Francisco ChronicleFull coverage

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What's in a name? Perhaps anxiety and overtreatment

What's in a name? Perhaps anxiety and overtreatment  Pharmacy NewsFull coverage

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In a First, Japan Says Fukushima Radiation Caused Worker's Cancer Death

In a First, Japan Says Fukushima Radiation Caused Worker's Cancer Death  New York TimesJapan Acknowledges the First Radiation-Linked Death From the Fukushima Nuclear Disaster  TIMEJapan Admits to First Radiation Death From Fukushima Nuclear Disaster  Newsweek5 Years After Japan Disasters, 'Temporary' Housing Is Feeling Permanent  NPRFirst worker to die from Fukushima radiation exposure officially recognized by Japan's government  SoraNews24Full coverage

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Natural ways to treat thyroid disease

Natural ways to treat thyroid disease  WNDU-TVFull coverage

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FDA grants RET inhibitor breakthrough therapy designation for lung, thyroid cancers

FDA grants RET inhibitor breakthrough therapy designation for lung, thyroid cancers  HealioLOXO-292 Granted Breakthrough Therapy Designation for Lung and Thyroid Cancer  Curetoday.comFull coverage

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Biothera Pharmaceuticals Announces Immuno-Oncology Clinical Trial Collaboration with AstraZeneca

Biothera Pharmaceuticals Announces Immuno-Oncology Clinical Trial Collaboration with AstraZeneca  GlobeNewswire (press release)Full coverage

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Copy Number Alteration Found to Be Associated with Cancer Mortality

Copy Number Alteration Found to Be Associated with Cancer Mortality  Genetic Engineering & Biotechnology NewsFull coverage

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New edition of thyroid cancer staging system shows better prediction of survival

New edition of thyroid cancer staging system shows better prediction of survival  HealioDifferentiated Thyroid Cancer Therapeutics Market : Popular Trends And New Business Opportunities 2024  Daily Industry ReportsFollicular Thyroid Cancer Drug Market Research, Growth Opportunities, Outlook and Forecast 2023  Business StrategiesFull coverage

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Cancer Stages: What You Need to Know

Cancer Stages: What You Need to Know  ParadeFull coverage

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HPV Vaccine May Reduce Risk Of Transmitting Devastating Throat Disease To Children

HPV Vaccine May Reduce Risk Of Transmitting Devastating Throat Disease To Children  ForbesFull coverage

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Biothera Pharmaceuticals Announces Immuno-Oncology Clinical Trial Collaboration with AstraZeneca

Biothera Pharmaceuticals Announces Immuno-Oncology Clinical Trial Collaboration with AstraZeneca  GlobeNewswire (press release)Full coverage

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Global Head and Neck Cancer Drugs/Therapeutics Market 2018 Top Manufactures, Growth Opportunities and ...

Global Head and Neck Cancer Drugs/Therapeutics Market 2018 Top Manufactures, Growth Opportunities and ...  Business StrategiesHead and Neck Cancer Treatment Market Research 2021 Region Wise Analysis of Top Players in Market by its Types ...  theperfectinvestor.comHead and Neck Cancer Drugs/Therapeutics Market Trends, Demand, Manufacturers Analysis and Opportunities 2025  MilTechFull coverage

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Cancer Stages: What You Need to Know

Cancer Stages: What You Need to Know  ParadeFull coverage

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HPV Vaccine May Reduce Risk Of Transmitting Devastating Throat Disease To Children

HPV Vaccine May Reduce Risk Of Transmitting Devastating Throat Disease To Children  ForbesFull coverage

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Safest level of alcohol consumption is none

Safest level of alcohol consumption is none  Independent OnlineFull coverage

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Conditions that could rob you of your voice

Conditions that could rob you of your voice  The CitizenFull coverage

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Facing up to the global challenges of ageing

Facing up to the global challenges of ageing  Nature.comFull coverage

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Safest level of alcohol consumption is none

Safest level of alcohol consumption is none  Independent OnlineFull coverage

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Conditions that could rob you of your voice

Conditions that could rob you of your voice  The CitizenFull coverage

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The US never banned asbestos. Now Trump may assist its comeback

The US never banned asbestos. Now Trump may assist its comeback  QuartzIs Asbestos Dangerous? The Trump Admin Might Be Bringing It Back  Elite DailyAsbestos: What New Rules Did the Trump EPA Propose?  Heavy.comMore Asbestos! More Asbestos! More Asbestos!  Rolling StoneFull coverage

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Facing up to the global challenges of ageing

Facing up to the global challenges of ageing  Nature.comFull coverage

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Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells  ScienceFull coverage

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Why I Went to ASHA ’ s Advocacy Day and Plan to Go Back

Do you remember those cellular commercials that bombarded us with the catchphrase, "Can you hear me now?" Guess what? Over time, it worked. A number of people switched their phone service to the company … maybe not because of the catchphrase itself, but possibly because of the totality of the message, repeated time and time again. A simple and efficient message changed minds and perspectives. And we can do the same when it comes to advocating for our professions of audiology and speech-language pathology. I'm an audiologist and not a minister, so I don't need to preach to the choir regarding these issues, but please indulge me sharing my first experience participating in ASHA's annual Capitol Hill Advocacy Day. In March, I partnered with dozens of other ASHA members hea...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q7H9SU

Why I Went to ASHA ’ s Advocacy Day and Plan to Go Back

Do you remember those cellular commercials that bombarded us with the catchphrase, "Can you hear me now?" Guess what? Over time, it worked. A number of people switched their phone service to the company … maybe not because of the catchphrase itself, but possibly because of the totality of the message, repeated time and time again. A simple and efficient message changed minds and perspectives. And we can do the same when it comes to advocating for our professions of audiology and speech-language pathology. I'm an audiologist and not a minister, so I don't need to preach to the choir regarding these issues, but please indulge me sharing my first experience participating in ASHA's annual Capitol Hill Advocacy Day. In March, I partnered with dozens of other ASHA members hea...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q7H9SU

Association between the sonographer’s experience and diagnostic performance of IOTA simple rules

To validate the clinical value of simple rules in distinguishing malignant adnexal masses from benign ones and to explore the effect of simple rules for experienced and less-experienced sonographers.

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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei in a liver-transplanted patient: a case report

Diagnostic work-ups in transplanted immunosuppressed patients are a challenge as non-specific findings may be interpreted as transplant-related complications. If the disease in question is rare and slowly deve...

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Association between the sonographer’s experience and diagnostic performance of IOTA simple rules

To validate the clinical value of simple rules in distinguishing malignant adnexal masses from benign ones and to explore the effect of simple rules for experienced and less-experienced sonographers.

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Anaphylactoid Reactions after Instillation of Contrast Material into the Urinary Tract: A Survey of Contemporary Practice Patterns and Review of the Literature

To assess drug reactions (ADRs) encountered by practicing urologists for contrast instilled into the urinary collecting system, and to describe current practice patterns regarding contrast administration into the urinary tract for patients with known contrast allergies. (Source: Urology)

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Anaphylactoid Reactions after Instillation of Contrast Material into the Urinary Tract: A Survey of Contemporary Practice Patterns and Review of the Literature

To assess drug reactions (ADRs) encountered by practicing urologists for contrast instilled into the urinary collecting system, and to describe current practice patterns regarding contrast administration into the urinary tract for patients with known contrast allergies. (Source: Urology)

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Why I Went to ASHA ’ s Advocacy Day and Plan to Go Back

Do you remember those cellular commercials that bombarded us with the catchphrase, "Can you hear me now?" Guess what? Over time, it worked. A number of people switched their phone service to the company … maybe not because of the catchphrase itself, but possibly because of the totality of the message, repeated time and time again. A simple and efficient message changed minds and perspectives. And we can do the same when it comes to advocating for our professions of audiology and speech-language pathology. I'm an audiologist and not a minister, so I don't need to preach to the choir regarding these issues, but please indulge me sharing my first experience participating in ASHA's annual Capitol Hill Advocacy Day. In March, I partnered with dozens of other ASHA members hea...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q7H9SU

Why I Went to ASHA ’ s Advocacy Day and Plan to Go Back

Do you remember those cellular commercials that bombarded us with the catchphrase, "Can you hear me now?" Guess what? Over time, it worked. A number of people switched their phone service to the company … maybe not because of the catchphrase itself, but possibly because of the totality of the message, repeated time and time again. A simple and efficient message changed minds and perspectives. And we can do the same when it comes to advocating for our professions of audiology and speech-language pathology. I'm an audiologist and not a minister, so I don't need to preach to the choir regarding these issues, but please indulge me sharing my first experience participating in ASHA's annual Capitol Hill Advocacy Day. In March, I partnered with dozens of other ASHA members hea...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Intraoperative factors associated with free flap failure in the head and neck region: a four-year retrospective study of 216 patients and review of the literature

The aim of this study was to identify intraoperative factors associated with free flap failure. The outcomes of 216 patients (220 flaps) were analyzed retrospectively. A statistical analysis was performed to determine the association of flap failure with the intraoperative factors of prolonged operation time, flap type, vascular pedicle at the recipient site, and use of vasoactive medication. A review of the recent literature was also conducted to identify other intraoperative risk factors. Univariate regression analysis revealed that a prolonged operative time (P=0.013) and the vascular pedicle at the recipient site (P=0.027) were primary risk factors for flap failure. (Source: International Journal of Oral and Maxillofacial Surgery)

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Diagnostic criteria in Pai syndrome: results of a case series and a literature review

Pai syndrome was originally described as the association of a midline cleft lip, midline facial polyps, and lipoma of the central nervous system. However, only a few patients present with the full triad, and most exhibit a wide spectrum of phenotypic variability. The aim of this study was to phenotypically delineate Pai syndrome and to propose new criteria to facilitate a clinical diagnosis in the future. The study cohort consisted of seven case patients and an additional 60 cases diagnosed with Pai syndrome identified in a literature review. (Source: International Journal of Oral and Maxillofacial Surgery)

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Intraoperative factors associated with free flap failure in the head and neck region: a four-year retrospective study of 216 patients and review of the literature

The aim of this study was to identify intraoperative factors associated with free flap failure. The outcomes of 216 patients (220 flaps) were analyzed retrospectively. A statistical analysis was performed to determine the association of flap failure with the intraoperative factors of prolonged operation time, flap type, vascular pedicle at the recipient site, and use of vasoactive medication. A review of the recent literature was also conducted to identify other intraoperative risk factors. Univariate regression analysis revealed that a prolonged operative time (P=0.013) and the vascular pedicle at the recipient site (P=0.027) were primary risk factors for flap failure. (Source: International Journal of Oral and Maxillofacial Surgery)

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Diagnostic criteria in Pai syndrome: results of a case series and a literature review

Pai syndrome was originally described as the association of a midline cleft lip, midline facial polyps, and lipoma of the central nervous system. However, only a few patients present with the full triad, and most exhibit a wide spectrum of phenotypic variability. The aim of this study was to phenotypically delineate Pai syndrome and to propose new criteria to facilitate a clinical diagnosis in the future. The study cohort consisted of seven case patients and an additional 60 cases diagnosed with Pai syndrome identified in a literature review. (Source: International Journal of Oral and Maxillofacial Surgery)

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Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma

AbstractNoise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of theStephania tetrandra S. Moore herb, significantly attenuated NIHL in CBA/CaJ mice. TET is known to exert antihypertensive and antiarrhythmic effects through the blocking of calcium channels. Whole-cell patch-clamp recording from adult spiral ganglion neurons showed that TET blocked the transient Ca2+...

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Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma

AbstractNoise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of theStephania tetrandra S. Moore herb, significantly attenuated NIHL in CBA/CaJ mice. TET is known to exert antihypertensive and antiarrhythmic effects through the blocking of calcium channels. Whole-cell patch-clamp recording from adult spiral ganglion neurons showed that TET blocked the transient Ca2+...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NRB6QT

Understanding Malignancies of the Thyroid Gland: Institutional Experience

AbstractTo study the epidemiological, pathological characters and determine survival in patients diagnosed of having thyroid gland malignancies. Retrospective chart review of patients having thyroid gland malignancies, which were managed by the two senior authors at our tertiary care institute from January 2000 to December 2006, were performed and evaluated in terms of various clinical, operative and histological parameters. Patients in which follow up of at least 10  years are available were included in the study. Survival was enquired telephonically in those patients who got cured and did not consent to come for follow up. Slides were reviewed. Statistical analysis was done using SPSS statistical software. Kaplan–Meier method was used for calculating surviv al. A total of 182 patients...

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Bacteriological Profile in Attico-antral type of Chronic Suppurative Otitis Media

AbstractChronic suppurative otitis media is defined as a chronic inflammation of the middle ear cleft, which presents with recurrent ear discharge through a tympanic membrane perforation. The purpose of this study was to find pattern of bacteriology in patients of atticoantral type of chronic suppurative otitis media as it will help the clinician to decide the effective antibiotics to be prescribed. This prospective and observational study was conducted in the Department of ENT in collaboration with Department of Microbiology, Government Medical College and Hospital, Chandigarh. The ear discharge specimen of all patients meeting the inclusion criteria were collected and sent for microbial examination. Culture positive samples were subjected to antibiotic sensitivity. A total of one hundred...

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Management of Nasoorbitoethmoidal Fracture: An Institutional Experience

AbstractThe nasoorbitoethmoidal fractures remain the most complex of all facial fractures to diagnose and treat mainly because of the intricate anatomy and difficulty in fracture fixation. The number of such fractures are increasing with the more incidence of high-speed, high-force accidents. The nasoorbitoethmoidal fractures rarely occur as an isolated event. Associated injuries often include central nervous system injuries, cribriform plate fracture, cerebrospinal fluid rhinorrhea, and fractures of the frontal bone, orbital floor, and middle third of the face as well as injury to the lacrimal system. The appropriate management of these injuries require an understanding of the anatomic features of the region, the degree of severity of damage. The purpose of this article is to provide a ge...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nq1CEc

Understanding Malignancies of the Thyroid Gland: Institutional Experience

AbstractTo study the epidemiological, pathological characters and determine survival in patients diagnosed of having thyroid gland malignancies. Retrospective chart review of patients having thyroid gland malignancies, which were managed by the two senior authors at our tertiary care institute from January 2000 to December 2006, were performed and evaluated in terms of various clinical, operative and histological parameters. Patients in which follow up of at least 10  years are available were included in the study. Survival was enquired telephonically in those patients who got cured and did not consent to come for follow up. Slides were reviewed. Statistical analysis was done using SPSS statistical software. Kaplan–Meier method was used for calculating surviv al. A total of 182 patients...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NmHWAO

Bacteriological Profile in Attico-antral type of Chronic Suppurative Otitis Media

AbstractChronic suppurative otitis media is defined as a chronic inflammation of the middle ear cleft, which presents with recurrent ear discharge through a tympanic membrane perforation. The purpose of this study was to find pattern of bacteriology in patients of atticoantral type of chronic suppurative otitis media as it will help the clinician to decide the effective antibiotics to be prescribed. This prospective and observational study was conducted in the Department of ENT in collaboration with Department of Microbiology, Government Medical College and Hospital, Chandigarh. The ear discharge specimen of all patients meeting the inclusion criteria were collected and sent for microbial examination. Culture positive samples were subjected to antibiotic sensitivity. A total of one hundred...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHsTiS

Management of Nasoorbitoethmoidal Fracture: An Institutional Experience

AbstractThe nasoorbitoethmoidal fractures remain the most complex of all facial fractures to diagnose and treat mainly because of the intricate anatomy and difficulty in fracture fixation. The number of such fractures are increasing with the more incidence of high-speed, high-force accidents. The nasoorbitoethmoidal fractures rarely occur as an isolated event. Associated injuries often include central nervous system injuries, cribriform plate fracture, cerebrospinal fluid rhinorrhea, and fractures of the frontal bone, orbital floor, and middle third of the face as well as injury to the lacrimal system. The appropriate management of these injuries require an understanding of the anatomic features of the region, the degree of severity of damage. The purpose of this article is to provide a ge...

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Psychometric properties the Iranian version of Older People’s Quality Of Life questionnaire (OPQOL)

Assessing quality of life (QOL) in elderly needs specific instruments. The Older People's Quality of Life Questionnaire (OPQOL-35) is one of the common tools that used for measuring quality of life in elderly ...

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Quality of life in older adults following a hip fracture: an empirical comparison of the ICECAP-O and the EQ-5D-3 L instruments

The purpose of this study was to empirically compare the performance of two generic preference based quality of life instruments, EQ-5D-3 L (with a health and physical function focus) and ICECAP-O (with a well...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NiJuM9

Psychometric properties the Iranian version of Older People’s Quality Of Life questionnaire (OPQOL)

Assessing quality of life (QOL) in elderly needs specific instruments. The Older People's Quality of Life Questionnaire (OPQOL-35) is one of the common tools that used for measuring quality of life in elderly ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PFum94

Quality of life in older adults following a hip fracture: an empirical comparison of the ICECAP-O and the EQ-5D-3 L instruments

The purpose of this study was to empirically compare the performance of two generic preference based quality of life instruments, EQ-5D-3 L (with a health and physical function focus) and ICECAP-O (with a well...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NiJuM9

Aus der Gutachtenpraxis: Überdosierung eines topischen α-Sympathomimetikums – ein Behandlungsfehler

Laryngo-Rhino-Otol 2018; 97: 639-640
DOI: 10.1055/a-0652-6199

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MRnatB

Endoskopische Sinuschirurgie: Checkliste hilft Problemfälle vorab zu entdecken

Laryngo-Rhino-Otol 2018; 97: 600-601
DOI: 10.1055/a-0621-1877

Error M et al. Single-Blinded Prospective Implementation of a Preoperative Imaging Checklist for Endoscopic Sinus Surgery. Otolaryngol Head Neck Surg 2018; 158: 177–180 Amerikanische HNO-Ärzt/innen untersuchten, ob die Einführung einer präoperativen radiologischen Checkliste die Identifizierung von kritischen Variationen in der Anatomie der Nasennebenhöhlen bei Patienten verbessert, die sich einer endoskopischen Sinuschirurgie unterziehen.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Fehlbildungschirurgie von Nase und Lippe

Laryngo-Rhino-Otol 2018; 97: 652-654
DOI: 10.1055/a-0652-6254

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOcetd

Penetration/Aspiration bei gesunden Erwachsenen: ein unterschätztes Phänomen?

Laryngo-Rhino-Otol 2018; 97: 601-602
DOI: 10.1055/a-0621-2095

Butler SG et al. Aspiration as a Function of Age, Sex, Liquid Type, Bolus Volume, and Bolus Delivery Across the Healthy Adult Life Span. Ann Otol Rhinol Laryngol 2018; 127: 21–32 Mittels funktioneller endoskopischer Schluck-Untersuchung (FEES) wurden Faktoren bestimmt, die im Verlauf des Erwachsenenlebens das Eindringen und die Aspiration während des Schluckens beeinflussen. Die amerikanischen HNO-Ärzt/innen vermuteten, dass bei gesunden Älteren ein höherer Fettgehalt in Flüssigkeiten, das Bolusvolumen, die Aufnahme mit einem Strohhalm, fortgeschrittenes Alter und männliches Geschlecht das Aspirationsrisiko erhöht.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nr7Dk1

Stents und Platzhalter in der endoskopischen endonasalen Nasennebenhöhlenchirurgie

Laryngo-Rhino-Otol 2018; 97: 606-614
DOI: 10.1055/a-0646-4223

In der endonasalen endoskopischen Chirurgie kam es im letzten Jahrzehnt zu Fortschritten durch ein verbessertes Verständnis der Mikroanatomie, den Zugewinn additiver medikamentöser Therapieoptionen und die Optimierung der instrumentellen Technik. In den gleichen Kontext kann die Weiterentwicklung und Beforschung röhrenförmiger oder solider Platzhalter („stents" oder „spacer") mit und ohne simultane Freisetzung von Medikamenten gestellt werden – der vorliegende Übersichtsbeitrag stellt den aktuellen Stand dieser Entwicklungen vor.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PFfLdW

Strategien zur Vermeidung von Burnout bei Ärzten

Laryngo-Rhino-Otol 2018; 97: 603-603
DOI: 10.1055/a-0656-9290

West CP. Dyrbye LN. Erwin PJ. et al. Interventions to prevent and reduce physian burn out: A systematic review and metaanalysis. Lancet 2016; 388: 2273 – 2281 Burnout wird von der Psychologin C. Marflach definiert als Zustand, in dem Ärzte eine Erosion an Werten, Würde, Geist und Motivation in ihrer Arbeit erleben. Die dabei auftretende sogenannte Depersonalisation meint eine zynische Grundhaltung und fehlende innere Verbindung zum Inhalt der Medizin, dem Wohl der Patienten.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Fragen für die Facharztprüfung

Laryngo-Rhino-Otol 2018; 97: 650-651
DOI: 10.1055/a-0652-6210

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHh3oL

Allergiediagnostik mit dem Pricktest

Laryngo-Rhino-Otol 2018; 97: 604-605
DOI: 10.1055/a-0652-6177

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MO8ATH

Die minimal-invasive Cochlea-Implantation – Chirurgische Machbarkeit und erste klinische Erfahrungen

Laryngo-Rhino-Otol
DOI: 10.1055/a-0671-2233

Hintergrund: In den vergangenen Jahren wurden die Indikationen zur Cochleaimplantation ausgeweitet und gleichzeitig schonendere operative Vorgehensweisen entwickelt. Methoden und Patienten: Das hier vorgestellte und von uns entwickelte Verfahren kombiniert eine verkürzte retroauriculäre Hautinzision von 25 mm Länge mit einer Reduzierung der Mastoidbohrung, der konsequenten Nutzung des Rundfensterzugangs und der Bohrung einer temporalen Implantatmulde (sog. Bremer Zugang). In der vorliegenden Arbeit werden erste Erfahrungen und Ergebnisse mit einem minimal-invasiven Vorgehen (MiCI) bei n = 31Patienten im Alter zwischen 9–79 Jahren berichtet. Ergebnisse: Es gelang die Länge des retroauriculären Hautschnitts auf im Mittel 29,7 mm, die Fläche der Mastoidbohrung auf 20mm2 und die Verweildauer um 0,55 Tage zu reduzieren. Es zeigte sich eine signifikante Lernkurve bei der Verkürzung der OP-Zeiten (p < 0.03). Die Frequenz und Art der Komplikationen entsprach der eines konventionellen Vorgehens. Schlußfolgerung: Die minimal-invasive Cochleaimplantation ist eine zuverlässige und sichere Methode zur Implantatversorgung.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PIGRRy

Aus der Gutachtenpraxis: Überdosierung eines topischen α-Sympathomimetikums – ein Behandlungsfehler

Laryngo-Rhino-Otol 2018; 97: 639-640
DOI: 10.1055/a-0652-6199

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MRnatB

Kommentar der Schriftleitung

Laryngo-Rhino-Otol 2018; 97: 596-597
DOI: 10.1055/a-0652-6144

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NRGa7K

Endoskopische Sinuschirurgie: Checkliste hilft Problemfälle vorab zu entdecken

Laryngo-Rhino-Otol 2018; 97: 600-601
DOI: 10.1055/a-0621-1877

Error M et al. Single-Blinded Prospective Implementation of a Preoperative Imaging Checklist for Endoscopic Sinus Surgery. Otolaryngol Head Neck Surg 2018; 158: 177–180 Amerikanische HNO-Ärzt/innen untersuchten, ob die Einführung einer präoperativen radiologischen Checkliste die Identifizierung von kritischen Variationen in der Anatomie der Nasennebenhöhlen bei Patienten verbessert, die sich einer endoskopischen Sinuschirurgie unterziehen.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NibTCa

Fehlbildungschirurgie von Nase und Lippe

Laryngo-Rhino-Otol 2018; 97: 652-654
DOI: 10.1055/a-0652-6254

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOcetd

Stents und Platzhalter in der endoskopischen endonasalen Nasennebenhöhlenchirurgie

Laryngo-Rhino-Otol 2018; 97: 606-614
DOI: 10.1055/a-0646-4223

In der endonasalen endoskopischen Chirurgie kam es im letzten Jahrzehnt zu Fortschritten durch ein verbessertes Verständnis der Mikroanatomie, den Zugewinn additiver medikamentöser Therapieoptionen und die Optimierung der instrumentellen Technik. In den gleichen Kontext kann die Weiterentwicklung und Beforschung röhrenförmiger oder solider Platzhalter („stents" oder „spacer") mit und ohne simultane Freisetzung von Medikamenten gestellt werden – der vorliegende Übersichtsbeitrag stellt den aktuellen Stand dieser Entwicklungen vor.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PFfLdW

Strategien zur Vermeidung von Burnout bei Ärzten

Laryngo-Rhino-Otol 2018; 97: 603-603
DOI: 10.1055/a-0656-9290

West CP. Dyrbye LN. Erwin PJ. et al. Interventions to prevent and reduce physian burn out: A systematic review and metaanalysis. Lancet 2016; 388: 2273 – 2281 Burnout wird von der Psychologin C. Marflach definiert als Zustand, in dem Ärzte eine Erosion an Werten, Würde, Geist und Motivation in ihrer Arbeit erleben. Die dabei auftretende sogenannte Depersonalisation meint eine zynische Grundhaltung und fehlende innere Verbindung zum Inhalt der Medizin, dem Wohl der Patienten.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MOsD4o

Fragen für die Facharztprüfung

Laryngo-Rhino-Otol 2018; 97: 650-651
DOI: 10.1055/a-0652-6210

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHh3oL

Allergiediagnostik mit dem Pricktest

Laryngo-Rhino-Otol 2018; 97: 604-605
DOI: 10.1055/a-0652-6177

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MO8ATH

Die minimal-invasive Cochlea-Implantation – Chirurgische Machbarkeit und erste klinische Erfahrungen

Laryngo-Rhino-Otol
DOI: 10.1055/a-0671-2233

Hintergrund: In den vergangenen Jahren wurden die Indikationen zur Cochleaimplantation ausgeweitet und gleichzeitig schonendere operative Vorgehensweisen entwickelt. Methoden und Patienten: Das hier vorgestellte und von uns entwickelte Verfahren kombiniert eine verkürzte retroauriculäre Hautinzision von 25 mm Länge mit einer Reduzierung der Mastoidbohrung, der konsequenten Nutzung des Rundfensterzugangs und der Bohrung einer temporalen Implantatmulde (sog. Bremer Zugang). In der vorliegenden Arbeit werden erste Erfahrungen und Ergebnisse mit einem minimal-invasiven Vorgehen (MiCI) bei n = 31Patienten im Alter zwischen 9–79 Jahren berichtet. Ergebnisse: Es gelang die Länge des retroauriculären Hautschnitts auf im Mittel 29,7 mm, die Fläche der Mastoidbohrung auf 20mm2 und die Verweildauer um 0,55 Tage zu reduzieren. Es zeigte sich eine signifikante Lernkurve bei der Verkürzung der OP-Zeiten (p < 0.03). Die Frequenz und Art der Komplikationen entsprach der eines konventionellen Vorgehens. Schlußfolgerung: Die minimal-invasive Cochleaimplantation ist eine zuverlässige und sichere Methode zur Implantatversorgung.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PIGRRy

OIPAV: an Integrated Software System for Ophthalmic Image Processing, Analysis, and Visualization

Abstract

Ophthalmic medical images, such as optical coherence tomography (OCT) images and color photo of fundus, provide valuable information for clinical diagnosis and treatment of ophthalmic diseases. In this paper, we introduce a software system specially oriented to ophthalmic images processing, analysis, and visualization (OIPAV) to assist users. OIPAV is a cross-platform system built on a set of powerful and widely used toolkit libraries. Based on the plugin mechanism, the system has an extensible framework. It provides rich functionalities including data I/O, image processing, interaction, ophthalmic diseases detection, data analysis, and visualization. By using OIPAV, users can easily access to the ophthalmic image data manufactured from different imaging devices, facilitate workflows of processing ophthalmic images, and improve quantitative evaluations. With a satisfying function scalability and expandability, the software is applicable for both ophthalmic researchers and clinicians.

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OIPAV: an Integrated Software System for Ophthalmic Image Processing, Analysis, and Visualization

Abstract

Ophthalmic medical images, such as optical coherence tomography (OCT) images and color photo of fundus, provide valuable information for clinical diagnosis and treatment of ophthalmic diseases. In this paper, we introduce a software system specially oriented to ophthalmic images processing, analysis, and visualization (OIPAV) to assist users. OIPAV is a cross-platform system built on a set of powerful and widely used toolkit libraries. Based on the plugin mechanism, the system has an extensible framework. It provides rich functionalities including data I/O, image processing, interaction, ophthalmic diseases detection, data analysis, and visualization. By using OIPAV, users can easily access to the ophthalmic image data manufactured from different imaging devices, facilitate workflows of processing ophthalmic images, and improve quantitative evaluations. With a satisfying function scalability and expandability, the software is applicable for both ophthalmic researchers and clinicians.

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Development of a skin-friendly microemulsion for dermal allergen-specific immunotherapy

We examined epidermal penetration of Alexa Fluor-647 labelled bee-venom phospholipase A2 (Api m 1) using the Franz diffusion cell set up and confocal laser-scanning microscopy. First results of an in-vivo Api m 1-allergic mouse model indicated the protective efficacy of dermal AIT with our newly developed microemulsion.Summarily, the developed microemulsion is a suitable, stable drug delivery system for the topical administration of proteogenic allergens into the epidermis and is able to reach dendritic cells in the skin.Graphical abstract (Source: International Journal of Pharmaceutics)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MTdSgG

Development of a skin-friendly microemulsion for dermal allergen-specific immunotherapy

We examined epidermal penetration of Alexa Fluor-647 labelled bee-venom phospholipase A2 (Api m 1) using the Franz diffusion cell set up and confocal laser-scanning microscopy. First results of an in-vivo Api m 1-allergic mouse model indicated the protective efficacy of dermal AIT with our newly developed microemulsion.Summarily, the developed microemulsion is a suitable, stable drug delivery system for the topical administration of proteogenic allergens into the epidermis and is able to reach dendritic cells in the skin.Graphical abstract (Source: International Journal of Pharmaceutics)

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What is new in HIES? Recent insights from the interface of primary immune deficiency and atopy

Purpose of review Understanding the pathophysiology of monogenic primary immunodeficiency (PID) with atopic presentation has pivotal implications for intervention strategies and potentially wider polygenic atopic-related traits. This review will discuss advances in gene discovery arising from monogenic defects at the interface between PID and atopy, notably the hyper-IgE syndromes. Recent findings Key molecular pathways underlying development of primary atopic diseases have recently been proposed. We test this classification through reviewing novel genes reported in the last 2 years and compare insights from pathway-analysis of genome-wide association studies (GWAS) of atopic-related traits. Growing access to next-generation sequencing (NGS) has resulted in a surge in gene discovery, highlighting the utility and some pitfalls of this approach in clinical practice. The variability of presenting phenotypes reveals important gene-dosage effects. This has important implications for therapeutic strategies such as protein stabilization and modulators of JAK-STAT or TH2-cytokine signalling. We also consider the therapeutic implications raised by CARD11 deficiency, and wider applications of NGS including polygenic risk score in atopy. Summary Disorders presenting at the interface between PID and allergy are often difficult to diagnose, with serious consequences if missed. Application of NGS has already provided critical insights to pathways enabling targeted therapeutic interventions, and potential wider translation to polygenic disorders. Correspondence to Mark J. Ponsford, Immunodeficiency Centre for Wales, University Hospital of Wales; Cardiff University, Cardiff, UK. E-mail: ponsfordm@cardiff.ac.uk Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.co-allergy.com). Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q3ay0u

What is new in HIES? Recent insights from the interface of primary immune deficiency and atopy

Purpose of review Understanding the pathophysiology of monogenic primary immunodeficiency (PID) with atopic presentation has pivotal implications for intervention strategies and potentially wider polygenic atopic-related traits. This review will discuss advances in gene discovery arising from monogenic defects at the interface between PID and atopy, notably the hyper-IgE syndromes. Recent findings Key molecular pathways underlying development of primary atopic diseases have recently been proposed. We test this classification through reviewing novel genes reported in the last 2 years and compare insights from pathway-analysis of genome-wide association studies (GWAS) of atopic-related traits. Growing access to next-generation sequencing (NGS) has resulted in a surge in gene discovery, highlighting the utility and some pitfalls of this approach in clinical practice. The variability of presenting phenotypes reveals important gene-dosage effects. This has important implications for therapeutic strategies such as protein stabilization and modulators of JAK-STAT or TH2-cytokine signalling. We also consider the therapeutic implications raised by CARD11 deficiency, and wider applications of NGS including polygenic risk score in atopy. Summary Disorders presenting at the interface between PID and allergy are often difficult to diagnose, with serious consequences if missed. Application of NGS has already provided critical insights to pathways enabling targeted therapeutic interventions, and potential wider translation to polygenic disorders. Correspondence to Mark J. Ponsford, Immunodeficiency Centre for Wales, University Hospital of Wales; Cardiff University, Cardiff, UK. E-mail: ponsfordm@cardiff.ac.uk Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.co-allergy.com). Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Ethnobotanical survey of plant species for herbal tea in a Yao autonomous county (Jianghua, China): results of a 2-year study of traditional medicinal markets on the Dragon Boat Festival

Herbal tea is widely consumed in Jianghua, a Yao autonomous county in Hunan Province, China, to prevent and treat diseases. The materials in herbal tea at the traditional medicinal markets at the Dragon Boat F...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cv2B1g

Ethnobotanical survey of plant species for herbal tea in a Yao autonomous county (Jianghua, China): results of a 2-year study of traditional medicinal markets on the Dragon Boat Festival

Herbal tea is widely consumed in Jianghua, a Yao autonomous county in Hunan Province, China, to prevent and treat diseases. The materials in herbal tea at the traditional medicinal markets at the Dragon Boat F...

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Medical Museum Science Cafe - On the Centenary of the 1918 Influenza: Lessons from the Past and Planning for the Future

Date: Tuesday, 10 23, 2018; Speaker: Jeffery Taubenberger, Chief, Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases NIH; 2500 (Source: NIH Calendar of Events)

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On the Crossroads of Glycobiology, Immunology and the Microbiome

Date: Monday, 09 10, 2018; Speaker: Dr. Christine Szymanski, How important are sugars for Campylobacter jejuni?, Professor of Microbiology, University of Georgia; Dr. Mihai Pop, Challenges and opportunities in Computational microbiome-ology, Professor, U of MD Institute for Advanced Computer Studies; Dr. Andrey Morgun, Transkingdom networks reveal key players of host-microbiota interactions, Associate Professor, Oregon State University ; Dr. Stephanie Oliver-Van Stichelen , non-nutritive sweeteners impact on infant metabolism and nascent microbiome, NIDDK; Dr. Catherine Leimkuhler Grimes, Breaking down bacterial cell walls to understand inflammation , Assistant Professor, University of Delaware; Dr. Ed Harhaj, Regulation of innate immune signaling by selective autophagy receptor Tax1BP1, P...

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Positioning and function of follicular helper T cells

Date: Tuesday, 09 25, 2018; Speaker: Hai Qi, Professor, Institute for Immunology, School of Medicine, Tsinghua University; 5625 Fishers Lane; 5th Floor Conference Room (Source: NIH Calendar of Events)

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Medical Museum Science Cafe - On the Centenary of the 1918 Influenza: Lessons from the Past and Planning for the Future

Date: Tuesday, 10 23, 2018; Speaker: Jeffery Taubenberger, Chief, Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases NIH; 2500 (Source: NIH Calendar of Events)

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On the Crossroads of Glycobiology, Immunology and the Microbiome

Date: Monday, 09 10, 2018; Speaker: Dr. Christine Szymanski, How important are sugars for Campylobacter jejuni?, Professor of Microbiology, University of Georgia; Dr. Mihai Pop, Challenges and opportunities in Computational microbiome-ology, Professor, U of MD Institute for Advanced Computer Studies; Dr. Andrey Morgun, Transkingdom networks reveal key players of host-microbiota interactions, Associate Professor, Oregon State University ; Dr. Stephanie Oliver-Van Stichelen , non-nutritive sweeteners impact on infant metabolism and nascent microbiome, NIDDK; Dr. Catherine Leimkuhler Grimes, Breaking down bacterial cell walls to understand inflammation , Assistant Professor, University of Delaware; Dr. Ed Harhaj, Regulation of innate immune signaling by selective autophagy receptor Tax1BP1, P...

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Children's Consonant Acquisition in 27 Languages: A Cross-Linguistic Review.

Conclusions: Children across the world acquire consonants at a young age. Five-year-old children have acquired most consonants within their ambient language; however, individual variability should be considered. Supplemental Material: https://ift.tt/2oHkpg1. PMID: 30177993 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

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How Do Age and Hearing Loss Impact Spectral Envelope Perception?

Conclusions: The spectral envelope perception as measured by spectral modulation detection thresholds is compromised by hearing loss at higher spectral modulation frequencies, consistent with predictions of reduced spectral resolution known to accompany sensorineural hearing loss. Spectral envelope perception is not negatively impacted by advancing age at any spectral modulation frequency between 0.5 and 8.0 cycles/octave. PMID: 30178062 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Continuous Vocal Fry Simulated in Laboratory Subjects: A Preliminary Report on Voice Production and Listener Ratings.

Conclusions: Thirty minutes of simulated, continuous vocal fry worsened some voice measures when compared with a habitual voice quality. Samples of continuous vocal fry were rated as significantly less employable, less natural, and requiring greater listener concentration as compared with samples of habitual voice quality. Future studies should include habitual users of vocal fry to investigate speech stimulability and adaptation with cueing to further understand pathogenesis of vocal fry. PMID: 30178028 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

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Children's Consonant Acquisition in 27 Languages: A Cross-Linguistic Review.

Conclusions: Children across the world acquire consonants at a young age. Five-year-old children have acquired most consonants within their ambient language; however, individual variability should be considered. Supplemental Material: https://ift.tt/2oHkpg1. PMID: 30177993 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

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Hematopoietic Stem/Progenitor Cell Dependent Participation of Innate Lymphoid Cells in Low-Intensity Sterile Inflammation

Sarantis Korniotis, Thomas B. Thornley, Periklis Kyriazis, Evangelos Theodorou, Lingzhi Ma, Lisa S. Li, Efi Kokkotou, Terry B. Strom, Maria Koulmanda (Source: Frontiers in Immunology)

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Recognition of the peripheral airway impairment phenotype in well controlled asthmatic children

Although current National Asthma Education and Prevention Program (NAEPP) asthma guidelines1 have proven effective, a considerable number of children2 and adults3 experience poor asthma control. The peripheral airways defined as distal to the 7th or 8th generation of the tracheobronchial tree, with an intra-luminal diameter of (Source: Annals of Allergy, Asthma and Immunology)

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RhoA/ROCK Signaling Modulates Lineage Commitment of Mesenchymal Stem Cells in Asthma through Lef1

MSCs are critical in airway repair/remodeling in asthma. RhoA/ROCK signaling functions as a molecular switch for the lineage fate of MSCs during airway repair/remodeling. Targeting RhoA/ROCK signaling might be an effective therapeutic strategy for asthma (Source: Journal of Allergy and Clinical Immunology)

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Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency

Inherited defects in adenosine deaminase (ADA) cause a subtype of severe combined immunodeficiency (SCID), known as ADA-SCID. Most affected infants can be diagnosed while still asymptomatic by a SCID newborn screening test, allowing early initiation of therapy. We reviewed the evidence currently available and propose a consensus management strategy. In addition to the treatment of the immune deficiency of ADA-SCID, patients should be followed for specific non-infectious respiratory, neurological and biochemical complications associated with ADA deficiency. (Source: Journal of Allergy and Clinical Immunology)

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Acute respiratory infections in early childhood and risk of asthma at 7 years of age

In this population-based birth cohort study, increased number of acute respiratory infections in the first 24 months of life was associated with an increased risk for asthma at 7 years of age, suggesting shared pathophysiologic mechanisms. (Source: Journal of Allergy and Clinical Immunology)

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Comparison of Antibacterial and Immunological Properties of Mesenchymal Stem/Stromal Cells from Equine Bone Marrow, Endometrium, and Adipose Tissue

Stem Cells and Development, Ahead of Print. (Source: Stem Cells and Development)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ClPHD1

Comparison of comorbid diagnoses in children with and without eosinophilic esophagitis in a large population

Eosinophilic esophagitis (EoE) is a chronic  immune-mediated inflammatory condition characterized by esophageal dysfunction with associated eosinophilic infiltration of the esophageal mucosa, occurring in 1/2000 individuals.1,2 Since the 1990s, EoE has been recognized as a clinically distinct condition, being seen with increasing incidence and prevalence over time, and currently accounting for the most common cause of chronic dysphagia in pediatric patients in the developed world.3-6 The pathophysiology is frequently recognized as a food allergy-driven process, characterized by a TH2-type immune response, with a high rate of concomit ant IgE-mediated food allergy observed in patients. (Source: Annals of Allergy, Asthma and Immunology)

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Hematopoietic Stem/Progenitor Cell Dependent Participation of Innate Lymphoid Cells in Low-Intensity Sterile Inflammation

Sarantis Korniotis, Thomas B. Thornley, Periklis Kyriazis, Evangelos Theodorou, Lingzhi Ma, Lisa S. Li, Efi Kokkotou, Terry B. Strom, Maria Koulmanda (Source: Frontiers in Immunology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MTAXQJ

Recognition of the peripheral airway impairment phenotype in well controlled asthmatic children

Although current National Asthma Education and Prevention Program (NAEPP) asthma guidelines1 have proven effective, a considerable number of children2 and adults3 experience poor asthma control. The peripheral airways defined as distal to the 7th or 8th generation of the tracheobronchial tree, with an intra-luminal diameter of (Source: Annals of Allergy, Asthma and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2M0vgLf

Paraben exposures and asthma-related outcomes among children from the U.S. general population

Exposure to methyl and propyl paraben, antimicrobial agents widely used in consumer products, was found to be associated with ED visits among asthmatic boys. (Source: Journal of Allergy and Clinical Immunology)

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Dupilumab progressively improves systemic and cutaneous abnormalities in atopic dermatitis patients

Dupilumab suppressed cutaneous and systemic measures of inflammation while improving epidermal pathology and clinical disease-severity scores at 4 weeks (maximally at 16 weeks) in moderate-to-severe atopic dermatitis, confirming atopic dermatitis as a Type 2-driven disease. (Source: Journal of Allergy and Clinical Immunology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ClQinY

RhoA/ROCK Signaling Modulates Lineage Commitment of Mesenchymal Stem Cells in Asthma through Lef1

MSCs are critical in airway repair/remodeling in asthma. RhoA/ROCK signaling functions as a molecular switch for the lineage fate of MSCs during airway repair/remodeling. Targeting RhoA/ROCK signaling might be an effective therapeutic strategy for asthma (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MPH7kt

Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency

Inherited defects in adenosine deaminase (ADA) cause a subtype of severe combined immunodeficiency (SCID), known as ADA-SCID. Most affected infants can be diagnosed while still asymptomatic by a SCID newborn screening test, allowing early initiation of therapy. We reviewed the evidence currently available and propose a consensus management strategy. In addition to the treatment of the immune deficiency of ADA-SCID, patients should be followed for specific non-infectious respiratory, neurological and biochemical complications associated with ADA deficiency. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2M7dkyQ

Acute respiratory infections in early childhood and risk of asthma at 7 years of age

In this population-based birth cohort study, increased number of acute respiratory infections in the first 24 months of life was associated with an increased risk for asthma at 7 years of age, suggesting shared pathophysiologic mechanisms. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NfHCE7

Comparison of Antibacterial and Immunological Properties of Mesenchymal Stem/Stromal Cells from Equine Bone Marrow, Endometrium, and Adipose Tissue

Stem Cells and Development, Ahead of Print. (Source: Stem Cells and Development)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ClPHD1

Comparison of comorbid diagnoses in children with and without eosinophilic esophagitis in a large population

Eosinophilic esophagitis (EoE) is a chronic  immune-mediated inflammatory condition characterized by esophageal dysfunction with associated eosinophilic infiltration of the esophageal mucosa, occurring in 1/2000 individuals.1,2 Since the 1990s, EoE has been recognized as a clinically distinct condition, being seen with increasing incidence and prevalence over time, and currently accounting for the most common cause of chronic dysphagia in pediatric patients in the developed world.3-6 The pathophysiology is frequently recognized as a food allergy-driven process, characterized by a TH2-type immune response, with a high rate of concomit ant IgE-mediated food allergy observed in patients. (Source: Annals of Allergy, Asthma and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NfHe8D

Low rates of recanalization for wide-necked aneurysms treated with stenting after balloon-assisted coiling: combination of techniques delivers stable and improved results during follow-up

Abstract

Purpose

In the treatment of wide-necked aneurysms, stenting may be required after balloon-assisted coiling (BAC) for reconstructing the lumen/flow of the parent artery in cases of coil herniation. The potential benefits and complications of both techniques remain unclear when used together. Our aim was to assess the safety and long-term angiographic outcomes of stenting after BAC.

Methods

Retrospective review of 87 unruptured wide necked aneurysms (in 80 patients) treated with BAC and requiring stent placement at the final stage of the procedure due to coil prolapse. Aneurysm characteristics, technical issues, clinical records, and MR results were assessed. Post-treatment and follow-up angiograms were evaluated by two independent reviewers and categorized as "stable," "further thrombosis," or "recanalization."

Results

The mean maximum diameter was 9.1 ± 4.7 mm and aspect ratio 1.20 ± 0.47. Complete and near-complete initial occlusion were observed in 53 (60.9%) and 28 (32.2%) of all treated aneurysms, respectively. Angiographic follow-up (80 aneurysms; mean, 34.68 ± 25.26 months) revealed stability and further thrombosis in 92.4% (74/80). Recanalization was observed in six cases (7.5%, 6/83), four of which were retreated. No significantly different outcomes were found in terms of aneurysm size (p = 0.641). Transient and reversible procedure-related complications occurred in eight (9.2%), minor permanent deficits in 2.3%, and major deficits, including death, in four cases (4.6%).

Conclusion

Our results suggest that treatment of wide-necked aneuryms with stent placement after BAC yields low recanalization rates and enhanced angiographic outcomes in long-term follow-up.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2M3Y4Tn

Low rates of recanalization for wide-necked aneurysms treated with stenting after balloon-assisted coiling: combination of techniques delivers stable and improved results during follow-up

Abstract

Purpose

In the treatment of wide-necked aneurysms, stenting may be required after balloon-assisted coiling (BAC) for reconstructing the lumen/flow of the parent artery in cases of coil herniation. The potential benefits and complications of both techniques remain unclear when used together. Our aim was to assess the safety and long-term angiographic outcomes of stenting after BAC.

Methods

Retrospective review of 87 unruptured wide necked aneurysms (in 80 patients) treated with BAC and requiring stent placement at the final stage of the procedure due to coil prolapse. Aneurysm characteristics, technical issues, clinical records, and MR results were assessed. Post-treatment and follow-up angiograms were evaluated by two independent reviewers and categorized as "stable," "further thrombosis," or "recanalization."

Results

The mean maximum diameter was 9.1 ± 4.7 mm and aspect ratio 1.20 ± 0.47. Complete and near-complete initial occlusion were observed in 53 (60.9%) and 28 (32.2%) of all treated aneurysms, respectively. Angiographic follow-up (80 aneurysms; mean, 34.68 ± 25.26 months) revealed stability and further thrombosis in 92.4% (74/80). Recanalization was observed in six cases (7.5%, 6/83), four of which were retreated. No significantly different outcomes were found in terms of aneurysm size (p = 0.641). Transient and reversible procedure-related complications occurred in eight (9.2%), minor permanent deficits in 2.3%, and major deficits, including death, in four cases (4.6%).

Conclusion

Our results suggest that treatment of wide-necked aneuryms with stent placement after BAC yields low recanalization rates and enhanced angiographic outcomes in long-term follow-up.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2M3Y4Tn

Lymph node structural cells rein in human immune responses

(PLOS) New research published in PLOS Biology by Anne Fletcher and Konstantin Knoblich and colleagues, from Monash Biomedicine Discovery Institute (BDI), has veered away from traditional immunology by turning the spotlight on the structural cells that build and support the immune-rich environment of lymph nodes. Their research shows that the so-called Fibroblastic Reticular Cells (FRCs) that form the inner structure of human tonsils and lymph nodes exert control over T cells and their response to infection. (Source: EurekAlert! - Biology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q7HpRK

Lymph node structural cells rein in human immune responses

(PLOS) New research published in PLOS Biology by Anne Fletcher and Konstantin Knoblich and colleagues, from Monash Biomedicine Discovery Institute (BDI), has veered away from traditional immunology by turning the spotlight on the structural cells that build and support the immune-rich environment of lymph nodes. Their research shows that the so-called Fibroblastic Reticular Cells (FRCs) that form the inner structure of human tonsils and lymph nodes exert control over T cells and their response to infection. (Source: EurekAlert! - Biology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q7HpRK

Pairing New Words With Unfamiliar Objects: Comparing Children With and Without Cochlear Implants.

Conclusion: This study provides preliminary evidence that children with cochlear implants approach mapping novel words to and soliciting information about unfamiliar objects differently than children with normal hearing. PMID: 30178030 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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Intraoperative factors associated with free flap failure in the head and neck region: a four-year retrospective study of 216 patients and review of the literature

The aim of this study was to identify intraoperative factors associated with free flap failure. The outcomes of 216 patients (220 flaps) were analyzed retrospectively. A statistical analysis was performed to determine the association of flap failure with the intraoperative factors of prolonged operation time, flap type, vascular pedicle at the recipient site, and use of vasoactive medication. A review of the recent literature was also conducted to identify other intraoperative risk factors. Univariate regression analysis revealed that a prolonged operative time (P=0.013) and the vascular pedicle at the recipient site (P=0.027) were primary risk factors for flap failure.

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Diagnostic criteria in Pai syndrome: results of a case series and a literature review

Pai syndrome was originally described as the association of a midline cleft lip, midline facial polyps, and lipoma of the central nervous system. However, only a few patients present with the full triad, and most exhibit a wide spectrum of phenotypic variability. The aim of this study was to phenotypically delineate Pai syndrome and to propose new criteria to facilitate a clinical diagnosis in the future. The study cohort consisted of seven case patients and an additional 60 cases diagnosed with Pai syndrome identified in a literature review.

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Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae

Auditory sensory outer hair cells are thought to amplify sound-induced basilar membrane vibration through a feedback mechanism to enhance hearing sensitivity. For optimal amplification, the outer hair cell-generated force must act on the basilar membrane at an appropriate time at every cycle. However, the temporal relationship between the outer hair cell-driven reticular lamina vibration and the basilar membrane vibration remains unclear. By measuring sub-nanometer vibrations directly from outer hair cells using a custom-built heterodyne low-coherence interferometer, we demonstrate in living gerbil cochleae that the reticular lamina vibration occurs after, not before, the basilar membrane vibration. Both tone- and click-induced responses indicate that the reticular lamina and basilar membr...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q2zqWl

Pairing New Words With Unfamiliar Objects: Comparing Children With and Without Cochlear Implants.

Conclusion: This study provides preliminary evidence that children with cochlear implants approach mapping novel words to and soliciting information about unfamiliar objects differently than children with normal hearing. PMID: 30178030 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wJRYSs

Diagnostic criteria in Pai syndrome: results of a case series and a literature review

Pai syndrome was originally described as the association of a midline cleft lip, midline facial polyps, and lipoma of the central nervous system. However, only a few patients present with the full triad, and most exhibit a wide spectrum of phenotypic variability. The aim of this study was to phenotypically delineate Pai syndrome and to propose new criteria to facilitate a clinical diagnosis in the future. The study cohort consisted of seven case patients and an additional 60 cases diagnosed with Pai syndrome identified in a literature review.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wNKduJ

Lymph node structural cells rein in human immune responses

(PLOS) New research published in PLOS Biology by Anne Fletcher and Konstantin Knoblich and colleagues, from Monash Biomedicine Discovery Institute (BDI), has veered away from traditional immunology by turning the spotlight on the structural cells that build and support the immune-rich environment of lymph nodes. Their research shows that the so-called Fibroblastic Reticular Cells (FRCs) that form the inner structure of human tonsils and lymph nodes exert control over T cells and their response to infection. (Source: EurekAlert! - Biology)

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The feasibility study of natural pigments as food colorants and seasonings pigments safety on dried tofu coloring

Publication date: Available online 5 September 2018Source: Food Science and Human WellnessAuthor(s): Wei-Sheng Lin, Pei Hua He, Chi-Fai Chau, Bo-Kang Liou, Shiming Li, Min-Hsiung PanAbstractIn order to improve appetite, attract consumers and even conform to the food culture, food coloring has become one of the necessary links in modern food processing. For example, dried-tofu will be colored by adding artificial food colors (AFCs) such as sunset yellow, cochineal red A or other seasonings like soy sauce. However, the dispute persists about whether AFCs are harmful to health. Some studies indicate AFCs affect children's intelligence and attention, cause hyperactivity, and allergy when children consumed ≥ 50 mg. In addition, researches showed that chemical soy sauce produces a trace of...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wK81zp

Lymph node structural cells rein in human immune responses

(PLOS) New research published in PLOS Biology by Anne Fletcher and Konstantin Knoblich and colleagues, from Monash Biomedicine Discovery Institute (BDI), has veered away from traditional immunology by turning the spotlight on the structural cells that build and support the immune-rich environment of lymph nodes. Their research shows that the so-called Fibroblastic Reticular Cells (FRCs) that form the inner structure of human tonsils and lymph nodes exert control over T cells and their response to infection. (Source: EurekAlert! - Biology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q7HpRK

The feasibility study of natural pigments as food colorants and seasonings pigments safety on dried tofu coloring

Publication date: Available online 5 September 2018Source: Food Science and Human WellnessAuthor(s): Wei-Sheng Lin, Pei Hua He, Chi-Fai Chau, Bo-Kang Liou, Shiming Li, Min-Hsiung PanAbstractIn order to improve appetite, attract consumers and even conform to the food culture, food coloring has become one of the necessary links in modern food processing. For example, dried-tofu will be colored by adding artificial food colors (AFCs) such as sunset yellow, cochineal red A or other seasonings like soy sauce. However, the dispute persists about whether AFCs are harmful to health. Some studies indicate AFCs affect children's intelligence and attention, cause hyperactivity, and allergy when children consumed ≥ 50 mg. In addition, researches showed that chemical soy sauce produces a trace of...

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The clinical application of BMP for reconstruction of alveolar cleft; 10 years follow up

To report on a 10-year assessment following the application of rhBMP-7 for reconstruction of alveolar clefts.

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The clinical application of BMP for reconstruction of alveolar cleft; 10 years follow up

To report on a 10-year assessment following the application of rhBMP-7 for reconstruction of alveolar clefts.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NS0gz1

Acute respiratory infections in early childhood and risk of asthma at 7 years of age

In this population-based birth cohort study, increased number of acute respiratory infections in the first 24 months of life was associated with an increased risk for asthma at 7 years of age, suggesting shared pathophysiologic mechanisms.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2M1tLfG

Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency

Inherited defects in adenosine deaminase (ADA) cause a subtype of severe combined immunodeficiency (SCID), known as ADA-SCID. Most affected infants can be diagnosed while still asymptomatic by a SCID newborn screening test, allowing early initiation of therapy. We reviewed the evidence currently available and propose a consensus management strategy. In addition to the treatment of the immune deficiency of ADA-SCID, patients should be followed for specific non-infectious respiratory, neurological and biochemical complications associated with ADA deficiency.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MTrXuV