AbstractTinnitus is conscious auditory perception without corresponding external stimuli resulting from neuronal activity along auditory pathway either in peripheral or central auditory system. The exact origin, pathophysiologic pathway and its treatment is still under exploration. The main risk factor is hearing loss, but can occur in patients with normal hearing. Auditory brainstem response test helps to objectify this subjective complaint and aid in locating its origin. P300 is late latency auditory evoked potential, objective marker of cognitive potential. The purpose of our study was to ascertain any significant difference in P300 latency and amplitude values in cases of sensorineural hearing loss with tinnitus when compared to controls (normal hearing subjects) and also to find any c...
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Κυριακή 7 Οκτωβρίου 2018
Tinnitus and Cognition: Linked?
A Study on Etiopathogenesis of Vocal Cord Paresis and Palsy in a Tertiary Centre
AbstractTo identify patients of vocal cord paresis and palsy and to establish an etiological diagnosis based on a study performed in a tertiary centre. Study was done prospectively in the Department of ENT in KIMS Hospital, Bangalore, for 1 year, from June 2016 to June 2017. 100 patients with vocal cord paresis and palsy were identified and examined by using various tests and investigations to establish the etiology. Most of the patients presented with complaints of change in voice (92%). Some of the other common presenting complaint s included noisy breathing and difficulty in swallowing, difficulty in voice production and vocal fatigue and cough. Unilateral paralysis (82%) was found to be more common than bilateral paralysis (18%), of which left (52%) was more commonly affected than ri...
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Tinnitus and Cognition: Linked?
AbstractTinnitus is conscious auditory perception without corresponding external stimuli resulting from neuronal activity along auditory pathway either in peripheral or central auditory system. The exact origin, pathophysiologic pathway and its treatment is still under exploration. The main risk factor is hearing loss, but can occur in patients with normal hearing. Auditory brainstem response test helps to objectify this subjective complaint and aid in locating its origin. P300 is late latency auditory evoked potential, objective marker of cognitive potential. The purpose of our study was to ascertain any significant difference in P300 latency and amplitude values in cases of sensorineural hearing loss with tinnitus when compared to controls (normal hearing subjects) and also to find any c...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pE23gt
A Study on Etiopathogenesis of Vocal Cord Paresis and Palsy in a Tertiary Centre
AbstractTo identify patients of vocal cord paresis and palsy and to establish an etiological diagnosis based on a study performed in a tertiary centre. Study was done prospectively in the Department of ENT in KIMS Hospital, Bangalore, for 1 year, from June 2016 to June 2017. 100 patients with vocal cord paresis and palsy were identified and examined by using various tests and investigations to establish the etiology. Most of the patients presented with complaints of change in voice (92%). Some of the other common presenting complaint s included noisy breathing and difficulty in swallowing, difficulty in voice production and vocal fatigue and cough. Unilateral paralysis (82%) was found to be more common than bilateral paralysis (18%), of which left (52%) was more commonly affected than ri...
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Impact of Infrared Radiation on UVB-induced Skin Tumourigenesis in Wild Type C57BL/6 Mice
DOI: 10.1039/C8PP00118A, Paper
Although infrared radiation (IR) represents more than 50 % of the solar radiation reaching the earth's surface, this waveband has been hardly investigated in terms of tumorigenesis. The objective of...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Impact of Infrared Radiation on UVB-induced Skin Tumourigenesis in Wild Type C57BL/6 Mice
DOI: 10.1039/C8PP00118A, Paper
Although infrared radiation (IR) represents more than 50 % of the solar radiation reaching the earth's surface, this waveband has been hardly investigated in terms of tumorigenesis. The objective of...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Gut microbiota and Hashimoto ’s thyroiditis
AbstractAbout two third of the human microbial commensal community, namely the gut microbiota, is hosted by the gastrointestinal tract which represents the largest interface of the organism to the external environment. This microbial community co-evolved in a symbiotic relationship with the human beings. Growing evidence support the notion that the microbiota plays a significant role in maintaining nutritional, metabolic and immunologic homeostasis in the host. Microbiota, beside the expected role in maintaining gastrointestinal homeostasis also exerts metabolic functions in nutrients digestion and absorption, detoxification and vitamins ' synthesis. Intestinal microbiota is also key in the correct development of the lymphoid system, 70% of which resides at the intestinal level. Availabl...
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Gut microbiota and Hashimoto ’s thyroiditis
AbstractAbout two third of the human microbial commensal community, namely the gut microbiota, is hosted by the gastrointestinal tract which represents the largest interface of the organism to the external environment. This microbial community co-evolved in a symbiotic relationship with the human beings. Growing evidence support the notion that the microbiota plays a significant role in maintaining nutritional, metabolic and immunologic homeostasis in the host. Microbiota, beside the expected role in maintaining gastrointestinal homeostasis also exerts metabolic functions in nutrients digestion and absorption, detoxification and vitamins ' synthesis. Intestinal microbiota is also key in the correct development of the lymphoid system, 70% of which resides at the intestinal level. Availabl...
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TACI Isoforms Regulate Ligand Binding and Receptor Function
Yolanda Garcia-Carmona, Adrian T. Ting, Lin Radigan, Sai Krishna Athuluri Divakar, Jose Chavez, Eric Meffre, Andrea Cerutti, Charlotte Cunningham-Rundles (Source: Frontiers in Immunology)
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Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT
ConclusionsClinical outcome of AIT depends on induction of blocking antibodies able to prevent the patient 's own IgE from allergen binding. Monitoring of clinical efficacy seems to be best achieved using the inhibition mediator release assay, as development of relevant blocking antibodies can be verified in a patient-tailored manner. (Source: Clinical and Translational Allergy)
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Effect of dexamethasone on seizures and inflammatory profile induced by Kindling Seizure Model
The objective of this study was to evaluate the effect of dexamethasone, on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by pentylenetetrazole (20 mg/kg) in alternated days for 15 days of treatment. The animals were divided into five groups: control group given saline, a group treated with diazepam (2 mg/kg) and groups treated with dexamethasone (1, 2 and 4 mg/kg). Open field test was conducted. The treatment with dexamethasone decrea sed the severity of seizures, also decreased TNF-alpha and Interleukin 1 beta levels in the hippocampus and TNF-alpha level in the serum. (Source: Journal of Neuroimmunology)
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TACI Isoforms Regulate Ligand Binding and Receptor Function
Yolanda Garcia-Carmona, Adrian T. Ting, Lin Radigan, Sai Krishna Athuluri Divakar, Jose Chavez, Eric Meffre, Andrea Cerutti, Charlotte Cunningham-Rundles (Source: Frontiers in Immunology)
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Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT
ConclusionsClinical outcome of AIT depends on induction of blocking antibodies able to prevent the patient 's own IgE from allergen binding. Monitoring of clinical efficacy seems to be best achieved using the inhibition mediator release assay, as development of relevant blocking antibodies can be verified in a patient-tailored manner. (Source: Clinical and Translational Allergy)
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Effect of dexamethasone on seizures and inflammatory profile induced by Kindling Seizure Model
The objective of this study was to evaluate the effect of dexamethasone, on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by pentylenetetrazole (20 mg/kg) in alternated days for 15 days of treatment. The animals were divided into five groups: control group given saline, a group treated with diazepam (2 mg/kg) and groups treated with dexamethasone (1, 2 and 4 mg/kg). Open field test was conducted. The treatment with dexamethasone decrea sed the severity of seizures, also decreased TNF-alpha and Interleukin 1 beta levels in the hippocampus and TNF-alpha level in the serum. (Source: Journal of Neuroimmunology)
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Rhinosectan® spray (containing xyloglucan) on the ciliary function of the nasal respiratory epithelium; results of an in vitro study
To assess the effects of Rhinosectan® spray, a medical device containing xyloglucan, on nasal ciliary function (in MucilAir™Nasal cells).
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Rhinosectan® spray (containing xyloglucan) on the ciliary function of the nasal respiratory epithelium; results of an in vitro study
To assess the effects of Rhinosectan® spray, a medical device containing xyloglucan, on nasal ciliary function (in MucilAir™Nasal cells).
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2y6mebI
Tinnitus and Cognition: Linked?
Abstract
Tinnitus is conscious auditory perception without corresponding external stimuli resulting from neuronal activity along auditory pathway either in peripheral or central auditory system. The exact origin, pathophysiologic pathway and its treatment is still under exploration. The main risk factor is hearing loss, but can occur in patients with normal hearing. Auditory brainstem response test helps to objectify this subjective complaint and aid in locating its origin. P300 is late latency auditory evoked potential, objective marker of cognitive potential. The purpose of our study was to ascertain any significant difference in P300 latency and amplitude values in cases of sensorineural hearing loss with tinnitus when compared to controls (normal hearing subjects) and also to find any correlation between severity of tinnitus and cognition. This was a case control study conducted at the department of ENT at Safdarjung Hospital, New Delhi between September 2016 to March 2018. The study comprised of one hundred and six patients, out of which fifty five patients were having sensorineural hearing loss with tinnitus and fifty one patients were normal hearing subjects. General medical and audiological history and examination was done. Significant increase in P300 latency and decrease in P300 amplitude was found in sensorineural hearing loss with tinnitus cases on comparing with controls. The similar pattern of P300 values was observed on increasing severity of tinnitus and degree of hearing loss. Hence, results revealed the role of cognition and involvement of central auditory pathway in tinnitus generation.
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A Study on Etiopathogenesis of Vocal Cord Paresis and Palsy in a Tertiary Centre
Abstract
To identify patients of vocal cord paresis and palsy and to establish an etiological diagnosis based on a study performed in a tertiary centre. Study was done prospectively in the Department of ENT in KIMS Hospital, Bangalore, for 1 year, from June 2016 to June 2017. 100 patients with vocal cord paresis and palsy were identified and examined by using various tests and investigations to establish the etiology. Most of the patients presented with complaints of change in voice (92%). Some of the other common presenting complaints included noisy breathing and difficulty in swallowing, difficulty in voice production and vocal fatigue and cough. Unilateral paralysis (82%) was found to be more common than bilateral paralysis (18%), of which left (52%) was more commonly affected than right (48%) vocal cord. The most common age group affected was 51–60 years (24%) followed by 61–70 years (19%). Males (60%) were affected more than females (40%) in a ratio of 3:2 and among the affected males 73% were known smokers. The most common cause of vocal cord paresis and palsy was found to be idiopathic (38%), followed by primary laryngeal growths (27%). Other causes included carcinomas of lung, thyroid and oesophagus, traumatic, inflammatory, systemic diseases like Rheumatoid arthritis, Hypertension leading to stroke. Identifying the exact etiopathogenesis of vocal cord paresis and palsy in patients has been difficult and is very important in order to establish a proper diagnostic and treatment protocol for these patients.
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Tinnitus and Cognition: Linked?
Abstract
Tinnitus is conscious auditory perception without corresponding external stimuli resulting from neuronal activity along auditory pathway either in peripheral or central auditory system. The exact origin, pathophysiologic pathway and its treatment is still under exploration. The main risk factor is hearing loss, but can occur in patients with normal hearing. Auditory brainstem response test helps to objectify this subjective complaint and aid in locating its origin. P300 is late latency auditory evoked potential, objective marker of cognitive potential. The purpose of our study was to ascertain any significant difference in P300 latency and amplitude values in cases of sensorineural hearing loss with tinnitus when compared to controls (normal hearing subjects) and also to find any correlation between severity of tinnitus and cognition. This was a case control study conducted at the department of ENT at Safdarjung Hospital, New Delhi between September 2016 to March 2018. The study comprised of one hundred and six patients, out of which fifty five patients were having sensorineural hearing loss with tinnitus and fifty one patients were normal hearing subjects. General medical and audiological history and examination was done. Significant increase in P300 latency and decrease in P300 amplitude was found in sensorineural hearing loss with tinnitus cases on comparing with controls. The similar pattern of P300 values was observed on increasing severity of tinnitus and degree of hearing loss. Hence, results revealed the role of cognition and involvement of central auditory pathway in tinnitus generation.
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A Study on Etiopathogenesis of Vocal Cord Paresis and Palsy in a Tertiary Centre
Abstract
To identify patients of vocal cord paresis and palsy and to establish an etiological diagnosis based on a study performed in a tertiary centre. Study was done prospectively in the Department of ENT in KIMS Hospital, Bangalore, for 1 year, from June 2016 to June 2017. 100 patients with vocal cord paresis and palsy were identified and examined by using various tests and investigations to establish the etiology. Most of the patients presented with complaints of change in voice (92%). Some of the other common presenting complaints included noisy breathing and difficulty in swallowing, difficulty in voice production and vocal fatigue and cough. Unilateral paralysis (82%) was found to be more common than bilateral paralysis (18%), of which left (52%) was more commonly affected than right (48%) vocal cord. The most common age group affected was 51–60 years (24%) followed by 61–70 years (19%). Males (60%) were affected more than females (40%) in a ratio of 3:2 and among the affected males 73% were known smokers. The most common cause of vocal cord paresis and palsy was found to be idiopathic (38%), followed by primary laryngeal growths (27%). Other causes included carcinomas of lung, thyroid and oesophagus, traumatic, inflammatory, systemic diseases like Rheumatoid arthritis, Hypertension leading to stroke. Identifying the exact etiopathogenesis of vocal cord paresis and palsy in patients has been difficult and is very important in order to establish a proper diagnostic and treatment protocol for these patients.
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Rhinosectan ® spray (containing xyloglucan) on the ciliary function of the nasal respiratory epithelium; results of an in vitro study
Abstract
Background
To assess the effects of Rhinosectan® spray, a medical device containing xyloglucan, on nasal ciliary function (in MucilAir™Nasal cells).
Methods
MucilAir™Nasal, a three-dimensional organotypic airway tissue model (with different cell types), was treated with Rhinosectan® (30 µl) or with a control (saline solution). The effects of Rhinosectan® were evaluated at 15 and 60 min post-exposure by: measurement of the cilia beating frequency (Hz), mucin detection (Enzyme-Linked Lectin Assay—ELLA), mucociliary clearance (µm/s) and phagocytosis assay (fluorescence).
Results
Exposure of MucilAir™ to Rhinosectan® did not alter the cilia beating frequency at 15 and 60 min post-exposure (diluted and undiluted). Exposure to Rhinosectan® (undiluted) during 60 min increased mucociliary clearance (93.3 ± 2.1 µm/s vs. 80.9 ± 1.8 µm/s; p < 0.01) and phagocytic activity (1.89-fold increase) in comparison with saline solution. Moreover, a significant decrease in mucin concentration was observed after 15 min of exposure (171.4 ng/ml vs. 306.5 ng/ml; p < 0.01) and at 60 min post-treatment (242.7 ng/ml vs. 339 ng/ml; p < 0.05).
Conclusions
The application of Rhinosectan® to nasal epithelial cells does not impair ciliary movement, enhances mucociliary clearance and facilitates phagocytosis while reducing mucin secretion, which are optimal properties for the management of rhinitis and associated conditions.
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Rhinosectan ® spray (containing xyloglucan) on the ciliary function of the nasal respiratory epithelium; results of an in vitro study
Abstract
Background
To assess the effects of Rhinosectan® spray, a medical device containing xyloglucan, on nasal ciliary function (in MucilAir™Nasal cells).
Methods
MucilAir™Nasal, a three-dimensional organotypic airway tissue model (with different cell types), was treated with Rhinosectan® (30 µl) or with a control (saline solution). The effects of Rhinosectan® were evaluated at 15 and 60 min post-exposure by: measurement of the cilia beating frequency (Hz), mucin detection (Enzyme-Linked Lectin Assay—ELLA), mucociliary clearance (µm/s) and phagocytosis assay (fluorescence).
Results
Exposure of MucilAir™ to Rhinosectan® did not alter the cilia beating frequency at 15 and 60 min post-exposure (diluted and undiluted). Exposure to Rhinosectan® (undiluted) during 60 min increased mucociliary clearance (93.3 ± 2.1 µm/s vs. 80.9 ± 1.8 µm/s; p < 0.01) and phagocytic activity (1.89-fold increase) in comparison with saline solution. Moreover, a significant decrease in mucin concentration was observed after 15 min of exposure (171.4 ng/ml vs. 306.5 ng/ml; p < 0.01) and at 60 min post-treatment (242.7 ng/ml vs. 339 ng/ml; p < 0.05).
Conclusions
The application of Rhinosectan® to nasal epithelial cells does not impair ciliary movement, enhances mucociliary clearance and facilitates phagocytosis while reducing mucin secretion, which are optimal properties for the management of rhinitis and associated conditions.
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A Summary of Newer and Safer Opioid Formulations
Abstract
Purpose of the Review
The review provides a brief summary of newer and safer opioid formulations that are currently on the market.
Recent Findings
The FDA currently has on the market seven opioid formulations that have abuse-deterrent properties.
Summary
While prescription opioid abuse continues to be a problem today, the development of abuse-deterrent opioids may mitigate the incidence of abuse.
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Organization of Multidisciplinary Cancer Care for the Surgical Patient: Role of Anesthesiologists
Abstract
Purpose of Review
The purpose of this review is to describe significant recent trends or developments regarding the role of anesthesiologists in a multidisciplinary team approach to cancer care for the surgical patient. We also discuss our own institutional multidisciplinary approach as a comprehensive cancer center with high surgical volume.
Recent Findings
Beyond the multidisciplinary team meeting concept, and local, institution-specific, or national programs, more formalized concepts and models of perioperative care have evolved. These provide a framework for robust involvement of anesthesiologists in cancer care for the surgical patient, with the goal of allowing for optimal individualized cancer outcomes.
Summary
Because of the wide-ranging nature of their perioperative expertise, anesthesiologists play an important role in multidisciplinary team cancer care for surgical patients. This role has been seen in the recent trends toward clinical models, such as the perioperative surgical home and enhanced recovery programs. Areas for future research include multidisciplinary assessment of the impact of such models on perioperative cancer outcomes through integration of data from national outcomes groups.
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A Summary of Newer and Safer Opioid Formulations
Abstract
Purpose of the Review
The review provides a brief summary of newer and safer opioid formulations that are currently on the market.
Recent Findings
The FDA currently has on the market seven opioid formulations that have abuse-deterrent properties.
Summary
While prescription opioid abuse continues to be a problem today, the development of abuse-deterrent opioids may mitigate the incidence of abuse.
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Organization of Multidisciplinary Cancer Care for the Surgical Patient: Role of Anesthesiologists
Abstract
Purpose of Review
The purpose of this review is to describe significant recent trends or developments regarding the role of anesthesiologists in a multidisciplinary team approach to cancer care for the surgical patient. We also discuss our own institutional multidisciplinary approach as a comprehensive cancer center with high surgical volume.
Recent Findings
Beyond the multidisciplinary team meeting concept, and local, institution-specific, or national programs, more formalized concepts and models of perioperative care have evolved. These provide a framework for robust involvement of anesthesiologists in cancer care for the surgical patient, with the goal of allowing for optimal individualized cancer outcomes.
Summary
Because of the wide-ranging nature of their perioperative expertise, anesthesiologists play an important role in multidisciplinary team cancer care for surgical patients. This role has been seen in the recent trends toward clinical models, such as the perioperative surgical home and enhanced recovery programs. Areas for future research include multidisciplinary assessment of the impact of such models on perioperative cancer outcomes through integration of data from national outcomes groups.
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HPV vaccine expanded for people ages 27 to 45
Source: www.nytimes.com Authors: Denise Grady and Jan Hoffman The HPV vaccine, which prevents cervical cancer and other malignancies, is now approved […]
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HPV vaccine expanded for people ages 27 to 45
Source: www.nytimes.com Authors: Denise Grady and Jan Hoffman The HPV vaccine, which prevents cervical cancer and other malignancies, is now approved […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2INB0s1
Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT
Abstract
Background
The clinical benefit of allergen-specific immunotherapy (AIT) involves induction of blocking antibodies. It is not clear if these antibodies function via steric hindrance alone or a combination of levels, avidities, and epitope specificities, and clinical outcome cannot be predicted. We aim to in-depth characterize serum antibody profiles during birch pollen AIT, investigate therapy-induced antibodies for their capacity to block IgE binding to Bet v 1 and correlate data with clinical outcomes.
Methods
Immune responses of five birch pollen allergic patients were monitored during the first year of AIT by nasal provocation tests (NPTs), ImmunoCAP, immunoblots, direct and avidity enzyme-linked immunosorbent assays, mediator release assays, facilitated antigen binding (FAB) assays, and inhibition mediator release assays.
Results
There was no correlation between NPT results and therapy-induced changes in levels (IgE, IgG, IgA, IgM), avidities, or mediator release potency of Bet v 1-specific antibodies. In FAB assays, blocking antibodies initiated upon AIT were shown to prevent formation of Bet v 1-IgE complexes of an indicator serum pool and significantly correlated with clinical readout. Inhibition mediator release assays using patient-specific IgE for passive sensitization revealed therapy-induced blocking capacities with very good correlation to NPT results. Notably, this assay was the only one to detect a non-responder during treatment in this pilot study.
Conclusions
Clinical outcome of AIT depends on induction of blocking antibodies able to prevent the patient's own IgE from allergen binding. Monitoring of clinical efficacy seems to be best achieved using the inhibition mediator release assay, as development of relevant blocking antibodies can be verified in a patient-tailored manner.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C0RAmI
Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT
Abstract
Background
The clinical benefit of allergen-specific immunotherapy (AIT) involves induction of blocking antibodies. It is not clear if these antibodies function via steric hindrance alone or a combination of levels, avidities, and epitope specificities, and clinical outcome cannot be predicted. We aim to in-depth characterize serum antibody profiles during birch pollen AIT, investigate therapy-induced antibodies for their capacity to block IgE binding to Bet v 1 and correlate data with clinical outcomes.
Methods
Immune responses of five birch pollen allergic patients were monitored during the first year of AIT by nasal provocation tests (NPTs), ImmunoCAP, immunoblots, direct and avidity enzyme-linked immunosorbent assays, mediator release assays, facilitated antigen binding (FAB) assays, and inhibition mediator release assays.
Results
There was no correlation between NPT results and therapy-induced changes in levels (IgE, IgG, IgA, IgM), avidities, or mediator release potency of Bet v 1-specific antibodies. In FAB assays, blocking antibodies initiated upon AIT were shown to prevent formation of Bet v 1-IgE complexes of an indicator serum pool and significantly correlated with clinical readout. Inhibition mediator release assays using patient-specific IgE for passive sensitization revealed therapy-induced blocking capacities with very good correlation to NPT results. Notably, this assay was the only one to detect a non-responder during treatment in this pilot study.
Conclusions
Clinical outcome of AIT depends on induction of blocking antibodies able to prevent the patient's own IgE from allergen binding. Monitoring of clinical efficacy seems to be best achieved using the inhibition mediator release assay, as development of relevant blocking antibodies can be verified in a patient-tailored manner.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C0RAmI
HPV vaccine expanded for people ages 27 to 45
Source: www.nytimes.com Authors: Denise Grady and Jan Hoffman The HPV vaccine, which prevents cervical cancer and other malignancies, is now approved […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2INB0s1
HPV vaccine expanded for people ages 27 to 45
Source: www.nytimes.com Authors: Denise Grady and Jan Hoffman The HPV vaccine, which prevents cervical cancer and other malignancies, is now approved […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2INB0s1
Clinical Thyroidology®High-Impact Articles
Mary Ann Liebert, Inc., publishers and the American Thyroid Association salute Jerry Hershman, MD for his superb leadership and years as Editor-in-Chief of Clinical Thyroidology. We are pleased to welcome our new incoming editor in 2019, Angela Leung, MD, and wish her well in this important new role.
We invite you to read these top-read papers with free access through October 19, 2018.
Read Now:
The Increased Incidence of Thyroid Cancer Is Worldwide
Jerome M. Hershman
No Benefit of Levothyroxine Among Pregnant Hypothyroid and/or Hypothyroxinemic Women on Offspring IQ at Age 9 years
Angela M. Leung
Surgery for Hyperthyroidism Lowers Cardiovascular Mortality Compared with Radioactive Iodine
Andrew J. Day, Michael W. Yeh, Masha J. Livhits
Does Normal TSH Mean Euthyroidism in L-T4 Treatment?
Jacques Orgiazzi
Most "Recurrences" of Thyroid Cancer Represent Persistent Rather Than Recurrent Disease
Martin Biermann and Katrin Brauckhoff
Validation of American Thyroid Association Ultrasound Risk Assessment of Thyroid Nodules Selected for Ultrasound Fine-Needle Aspiration
Stephanie A. Fish
The post Clinical Thyroidology<sup>®</sup>High-Impact Articles appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rvctff
Clinical Thyroidology®High-Impact Articles
Mary Ann Liebert, Inc., publishers and the American Thyroid Association salute Jerry Hershman, MD for his superb leadership and years as Editor-in-Chief of Clinical Thyroidology. We are pleased to welcome our new incoming editor in 2019, Angela Leung, MD, and wish her well in this important new role.
We invite you to read these top-read papers with free access through October 19, 2018.
Read Now:
The Increased Incidence of Thyroid Cancer Is Worldwide
Jerome M. Hershman
No Benefit of Levothyroxine Among Pregnant Hypothyroid and/or Hypothyroxinemic Women on Offspring IQ at Age 9 years
Angela M. Leung
Surgery for Hyperthyroidism Lowers Cardiovascular Mortality Compared with Radioactive Iodine
Andrew J. Day, Michael W. Yeh, Masha J. Livhits
Does Normal TSH Mean Euthyroidism in L-T4 Treatment?
Jacques Orgiazzi
Most "Recurrences" of Thyroid Cancer Represent Persistent Rather Than Recurrent Disease
Martin Biermann and Katrin Brauckhoff
Validation of American Thyroid Association Ultrasound Risk Assessment of Thyroid Nodules Selected for Ultrasound Fine-Needle Aspiration
Stephanie A. Fish
The post Clinical Thyroidology<sup>®</sup>High-Impact Articles appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rvctff
Clinical Thyroidology®High-Impact Articles
Mary Ann Liebert, Inc., publishers and the American Thyroid Association salute Jerry Hershman, MD for his superb leadership and years as Editor-in-Chief of Clinical Thyroidology. We are pleased to welcome our new incoming editor in 2019, Angela Leung, MD, and wish her well in this important new role.
We invite you to read these top-read papers with free access through October 19, 2018.
Read Now:
The Increased Incidence of Thyroid Cancer Is Worldwide
Jerome M. Hershman
No Benefit of Levothyroxine Among Pregnant Hypothyroid and/or Hypothyroxinemic Women on Offspring IQ at Age 9 years
Angela M. Leung
Surgery for Hyperthyroidism Lowers Cardiovascular Mortality Compared with Radioactive Iodine
Andrew J. Day, Michael W. Yeh, Masha J. Livhits
Does Normal TSH Mean Euthyroidism in L-T4 Treatment?
Jacques Orgiazzi
Most "Recurrences" of Thyroid Cancer Represent Persistent Rather Than Recurrent Disease
Martin Biermann and Katrin Brauckhoff
Validation of American Thyroid Association Ultrasound Risk Assessment of Thyroid Nodules Selected for Ultrasound Fine-Needle Aspiration
Stephanie A. Fish
The post Clinical Thyroidology<sup>®</sup>High-Impact Articles appeared first on American Thyroid Association.
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VideoEndocrinology™ High-Impact Videos
VideoEndocrinology™
The Official Journal of: American Thyroid Association
FREE ACCESS through October 20, 2018.
Watch now:
Thyroid Fine-Needle Aspiration and Smearing Techniques
Mitsuyoshi Hirokawa, Ayana Suzuki, Akira Miyauchi
Thyroid Fine Needle Aspiration Smear Preparation
Juan Munoz Pena, Jeffrey Arnold
Transoral Endoscopic Thyroidectomy Vestibular Approach
Angkoon Anuwong, Thanyawat Sasanakietkul, Pornpeera Jitpratoom
An Elusive Parathyroid: Interesting Case Presentation
Anton F. Engelsman, Robert F. Parkyn, Andrew Carter, James Christie, Leigh W. Delbridge
Delphian Lymph Node Dissection: Surgical Dissection Technique as Illustrated by the Johns Hopkins Head and Neck Endocrine Surgery Division
Vaninder K. Dhillon, Jonathon O. Russell, Ralph P. Tufano
The post VideoEndocrinology™ High-Impact Videos appeared first on American Thyroid Association.
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Clinical Thyroidology®High-Impact Articles
Mary Ann Liebert, Inc., publishers and the American Thyroid Association salute Jerry Hershman, MD for his superb leadership and years as Editor-in-Chief of Clinical Thyroidology. We are pleased to welcome our new incoming editor in 2019, Angela Leung, MD, and wish her well in this important new role.
We invite you to read these top-read papers with free access through October 19, 2018.
Read Now:
The Increased Incidence of Thyroid Cancer Is Worldwide
Jerome M. Hershman
No Benefit of Levothyroxine Among Pregnant Hypothyroid and/or Hypothyroxinemic Women on Offspring IQ at Age 9 years
Angela M. Leung
Surgery for Hyperthyroidism Lowers Cardiovascular Mortality Compared with Radioactive Iodine
Andrew J. Day, Michael W. Yeh, Masha J. Livhits
Does Normal TSH Mean Euthyroidism in L-T4 Treatment?
Jacques Orgiazzi
Most "Recurrences" of Thyroid Cancer Represent Persistent Rather Than Recurrent Disease
Martin Biermann and Katrin Brauckhoff
Validation of American Thyroid Association Ultrasound Risk Assessment of Thyroid Nodules Selected for Ultrasound Fine-Needle Aspiration
Stephanie A. Fish
The post Clinical Thyroidology<sup>®</sup>High-Impact Articles appeared first on American Thyroid Association.
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VideoEndocrinology™ High-Impact Videos
VideoEndocrinology™
The Official Journal of: American Thyroid Association
FREE ACCESS through October 20, 2018.
Watch now:
Thyroid Fine-Needle Aspiration and Smearing Techniques
Mitsuyoshi Hirokawa, Ayana Suzuki, Akira Miyauchi
Thyroid Fine Needle Aspiration Smear Preparation
Juan Munoz Pena, Jeffrey Arnold
Transoral Endoscopic Thyroidectomy Vestibular Approach
Angkoon Anuwong, Thanyawat Sasanakietkul, Pornpeera Jitpratoom
An Elusive Parathyroid: Interesting Case Presentation
Anton F. Engelsman, Robert F. Parkyn, Andrew Carter, James Christie, Leigh W. Delbridge
Delphian Lymph Node Dissection: Surgical Dissection Technique as Illustrated by the Johns Hopkins Head and Neck Endocrine Surgery Division
Vaninder K. Dhillon, Jonathon O. Russell, Ralph P. Tufano
The post VideoEndocrinology™ High-Impact Videos appeared first on American Thyroid Association.
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Patterns of recognition of Arabic consonants by non-native children with cochlear implants and normal hearing
. (Source: Cochlear Implants International)
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Patterns of recognition of Arabic consonants by non-native children with cochlear implants and normal hearing
. (Source: Cochlear Implants International)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QupmEW
VideoEndocrinology™ High-Impact Videos
VideoEndocrinology™
The Official Journal of: American Thyroid Association
FREE ACCESS through October 20, 2018.
Watch now:
Thyroid Fine-Needle Aspiration and Smearing Techniques
Mitsuyoshi Hirokawa, Ayana Suzuki, Akira Miyauchi
Thyroid Fine Needle Aspiration Smear Preparation
Juan Munoz Pena, Jeffrey Arnold
Transoral Endoscopic Thyroidectomy Vestibular Approach
Angkoon Anuwong, Thanyawat Sasanakietkul, Pornpeera Jitpratoom
An Elusive Parathyroid: Interesting Case Presentation
Anton F. Engelsman, Robert F. Parkyn, Andrew Carter, James Christie, Leigh W. Delbridge
Delphian Lymph Node Dissection: Surgical Dissection Technique as Illustrated by the Johns Hopkins Head and Neck Endocrine Surgery Division
Vaninder K. Dhillon, Jonathon O. Russell, Ralph P. Tufano
The post VideoEndocrinology™ High-Impact Videos appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PjM2rn
Pret A Manger supplier rejects contamination claim
Vegan food brand CoYo says claims over second allergy fatality case are 'unfounded' (Source: FT.com - Drugs and Healthcare)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Pret a Manger: Second person dies from allergic reaction
A second person has died from an allergic reaction to one of Pret a Manger's products, the food chain confirmed Sunday. (Source: CNN.com - Health)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QxYqUE
VideoEndocrinology™ High-Impact Videos
VideoEndocrinology™
The Official Journal of: American Thyroid Association
FREE ACCESS through October 20, 2018.
Watch now:
Thyroid Fine-Needle Aspiration and Smearing Techniques
Mitsuyoshi Hirokawa, Ayana Suzuki, Akira Miyauchi
Thyroid Fine Needle Aspiration Smear Preparation
Juan Munoz Pena, Jeffrey Arnold
Transoral Endoscopic Thyroidectomy Vestibular Approach
Angkoon Anuwong, Thanyawat Sasanakietkul, Pornpeera Jitpratoom
An Elusive Parathyroid: Interesting Case Presentation
Anton F. Engelsman, Robert F. Parkyn, Andrew Carter, James Christie, Leigh W. Delbridge
Delphian Lymph Node Dissection: Surgical Dissection Technique as Illustrated by the Johns Hopkins Head and Neck Endocrine Surgery Division
Vaninder K. Dhillon, Jonathon O. Russell, Ralph P. Tufano
The post VideoEndocrinology™ High-Impact Videos appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PjM2rn
Pret A Manger supplier rejects contamination claim
Vegan food brand CoYo says claims over second allergy fatality case are 'unfounded' (Source: FT.com - Drugs and Healthcare)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Pret a Manger: Second person dies from allergic reaction
A second person has died from an allergic reaction to one of Pret a Manger's products, the food chain confirmed Sunday. (Source: CNN.com - Health)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QxYqUE
Pret A Manger supplier rejects contamination claim
Vegan food brand CoYo says claims over second allergy fatality case are 'unfounded' (Source: FT.com - Drugs and Healthcare)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Pret a Manger: Second person dies from allergic reaction
A second person has died from an allergic reaction to one of Pret a Manger's products, the food chain confirmed Sunday. (Source: CNN.com - Health)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QxYqUE
Pret A Manger supplier rejects contamination claim
Vegan food brand CoYo says claims over second allergy fatality case are 'unfounded' (Source: FT.com - Drugs and Healthcare)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Pret a Manger: Second person dies from allergic reaction
A second person has died from an allergic reaction to one of Pret a Manger's products, the food chain confirmed Sunday. (Source: CNN.com - Health)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QxYqUE
Human PBMCs fight or flight response to starvation stress: Increased T-reg, FOXP3, and TGF-β1 with decreased miR-21 and Constant miR-181c levels
This study introduced the serum starvation as a tool for immunoregulation which acts probably through increasing TGF-β1 production and inducing some alterations in microRNAs expression.Graphical abstractSerum starvation as potential tool in immunoregulation. (Source: Biomedicine and Pharmacotherapy)
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Quantifying beta-agonist utilization: Occasions or puffs?
Publication date: Available online 13 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Stanley J. Szefler, Heather E. Hoch, Michael Tuffli, Rahul Gondalia, Meredith A. Barrett, David Van Sickle, David A. Stempel (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Using single cell analysis for translational studies in immune mediated diseases: Opportunities and challenges
Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Siddhartha Sharma, Louis Gioia, Brian Abe, Marie Holt, Anne Costanzo, Lisa Kain, Andrew Su, Luc TeytonAbstractThe difficulty of studying small tissue samples and rare cell populations have been some of the main limitations in performing efficient translational studies of immune mediated diseases. Many of these conditions are grouped under the name of a single disease whilst there are strong suggestions that disease heterogeneity leads to variable disease progression as well as therapeutic responses. The recent development of single cell techniques, such as single cell RNA sequencing, gene expression profiling, or multiparametric cytometry, is likely to be a turning point. Single cell approaches provide resear...
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Human PBMCs fight or flight response to starvation stress: Increased T-reg, FOXP3, and TGF-β1 with decreased miR-21 and Constant miR-181c levels
This study introduced the serum starvation as a tool for immunoregulation which acts probably through increasing TGF-β1 production and inducing some alterations in microRNAs expression.Graphical abstractSerum starvation as potential tool in immunoregulation. (Source: Biomedicine and Pharmacotherapy)
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Quantifying beta-agonist utilization: Occasions or puffs?
Publication date: Available online 13 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Stanley J. Szefler, Heather E. Hoch, Michael Tuffli, Rahul Gondalia, Meredith A. Barrett, David Van Sickle, David A. Stempel (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Using single cell analysis for translational studies in immune mediated diseases: Opportunities and challenges
Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Siddhartha Sharma, Louis Gioia, Brian Abe, Marie Holt, Anne Costanzo, Lisa Kain, Andrew Su, Luc TeytonAbstractThe difficulty of studying small tissue samples and rare cell populations have been some of the main limitations in performing efficient translational studies of immune mediated diseases. Many of these conditions are grouped under the name of a single disease whilst there are strong suggestions that disease heterogeneity leads to variable disease progression as well as therapeutic responses. The recent development of single cell techniques, such as single cell RNA sequencing, gene expression profiling, or multiparametric cytometry, is likely to be a turning point. Single cell approaches provide resear...
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Palmaris Longus Tendinopathy Diagnosed with Ultrasound: A Case Report
This is a case of 52-year old deaf female who was referred to the electrodiagnostic (EDX) laboratory for evaluation of pain and parasthesias in the left upper limb. The EDX study was normal. However, ultrasound revealed tendinopathy of the palmaris longus tendon, manifested by increased hypoechogenecity, caliber, and tenderness to sonopalpation compared to the right side. To the authors ' knowledge there are no reported cases of palmaris longus tendinopathy diagnosed with ultrasound. This case supports the use of point of care ultrasound to explore other possible causes of pathology in patients with parasthesias in the context of a normal EDX study. (Source: PM and R)
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Palmaris Longus Tendinopathy Diagnosed with Ultrasound: A Case Report
This is a case of 52-year old deaf female who was referred to the electrodiagnostic (EDX) laboratory for evaluation of pain and parasthesias in the left upper limb. The EDX study was normal. However, ultrasound revealed tendinopathy of the palmaris longus tendon, manifested by increased hypoechogenecity, caliber, and tenderness to sonopalpation compared to the right side. To the authors ' knowledge there are no reported cases of palmaris longus tendinopathy diagnosed with ultrasound. This case supports the use of point of care ultrasound to explore other possible causes of pathology in patients with parasthesias in the context of a normal EDX study. (Source: PM and R)
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The steamy mirror of adolescent gamblers: Mentalization, impulsivity, and time horizon
Publication date: Available online 6 October 2018
Source: Addictive Behaviors
Author(s): Marina Cosenza, Maria Ciccarelli, Giovanna Nigro
Abstract
This study aimed to first investigate the role that general impairment in mentalization plays in gambling disorder and to analyze the interplay among mentalizing, impulsivity, and time perspective in adolescent gambling. Four hundred and ten late adolescents took part in the study. Participants were administered the South Oaks Gambling Screen Revised for Adolescents (SOGS-RA), the Reflective Functioning Questionnaire (RFQ-8), the Functional and Dysfunctional Impulsivity Scale (FDIS), and the 14-item Consideration of Future Consequences scale (CFC-14). The results showed that male adolescents are far more likely at-risk/problem gamblers than female adolescents. Furthermore, data indicated that the higher the gambling severity, the higher the dysfunctional impulsivity and the shorter the time horizon. Linear regression analysis showed that impairments in mentalizing represent a significant predictor of gambling severity. Finally, to clarify if dysfunctional impulsivity was on the path from uncertain mentalizing to gambling severity or if mentalizing was the mediator of the impact of functional impulsivity on gambling severity, data were submitted to path analysis. Results indicated that deficit in mentalizing has a direct effect on gambling severity and mediates the association between dysfunctional impulsivity and gambling involvement. The relation between gambling severity and RFQ-8 scores suggests that general impairment in mentalizing plays a key role in adolescent problematic gambling.
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Topical application of phenytoin or nifedipine-loaded PLGA microspheres promotes periodontal regeneration in vivo
Publication date: Available online 6 October 2018
Source: Archives of Oral Biology
Author(s): Xiao-Heng Zhao, Franklin R. Tay, Yan-Jun Fang, Liu-Yan Meng, Zhuan Bian
Abstract
Objectives
Gingival recession and alveolar bone loss are common manifestations of periodontitis. Periodontal regeneration is the ideal strategy for rehabilitating periodontal tissue defects and preventing tooth loss. The present study examined whether localized, topical application of gingival overgrowth-inducing drugs, phenytoin, nifedipine or cyclosporine, induces periodontal regeneration.
Methods
Polylactic-co-glycolic acid (PLGA) was used as the carrier for preparation of phenytoin, nifedipine or cyclosporine-loaded PLGA microspheres, using an oil-in-water emulsification technique. The drug-loaded microspheres were delivered to periodontal defects created on alveolar ridges mesial to the first maxillary molars of Sprague-Dawley rats. After eight weeks, the operation area in each rat, including the maxillary molars and periodontal tissues, was harvested and evaluated by micro-computed tomography, histochemical and immunohistochemical analyses.
Results
Physical parameters representative of periodontal regeneration, including the length of new alveolar bone (p < 0.01) and the area of new alveolar bone (p < 0.01) were significantly improved in the phenytoin group. Compared to other groups, the phenytoin group demonstrated increased expression of COL-1, VEGF-A, osteoblast and osteoclast markers (BMP-2, TGF-β1, OCN and TRAP staining), as well as decreased expression of MMP-8.
Conclusions
Results of the present study provided new evidence that localized, controlled release of phenytoin confers therapeutic benefits toward gingival recession and alveolar bone loss. Phenytoin appears to be a promising drug that promotes periodontal regeneration.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yoepx0
The steamy mirror of adolescent gamblers: Mentalization, impulsivity, and time horizon
Publication date: Available online 6 October 2018
Source: Addictive Behaviors
Author(s): Marina Cosenza, Maria Ciccarelli, Giovanna Nigro
Abstract
This study aimed to first investigate the role that general impairment in mentalization plays in gambling disorder and to analyze the interplay among mentalizing, impulsivity, and time perspective in adolescent gambling. Four hundred and ten late adolescents took part in the study. Participants were administered the South Oaks Gambling Screen Revised for Adolescents (SOGS-RA), the Reflective Functioning Questionnaire (RFQ-8), the Functional and Dysfunctional Impulsivity Scale (FDIS), and the 14-item Consideration of Future Consequences scale (CFC-14). The results showed that male adolescents are far more likely at-risk/problem gamblers than female adolescents. Furthermore, data indicated that the higher the gambling severity, the higher the dysfunctional impulsivity and the shorter the time horizon. Linear regression analysis showed that impairments in mentalizing represent a significant predictor of gambling severity. Finally, to clarify if dysfunctional impulsivity was on the path from uncertain mentalizing to gambling severity or if mentalizing was the mediator of the impact of functional impulsivity on gambling severity, data were submitted to path analysis. Results indicated that deficit in mentalizing has a direct effect on gambling severity and mediates the association between dysfunctional impulsivity and gambling involvement. The relation between gambling severity and RFQ-8 scores suggests that general impairment in mentalizing plays a key role in adolescent problematic gambling.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C15uFi
Topical application of phenytoin or nifedipine-loaded PLGA microspheres promotes periodontal regeneration in vivo
Publication date: Available online 6 October 2018
Source: Archives of Oral Biology
Author(s): Xiao-Heng Zhao, Franklin R. Tay, Yan-Jun Fang, Liu-Yan Meng, Zhuan Bian
Abstract
Objectives
Gingival recession and alveolar bone loss are common manifestations of periodontitis. Periodontal regeneration is the ideal strategy for rehabilitating periodontal tissue defects and preventing tooth loss. The present study examined whether localized, topical application of gingival overgrowth-inducing drugs, phenytoin, nifedipine or cyclosporine, induces periodontal regeneration.
Methods
Polylactic-co-glycolic acid (PLGA) was used as the carrier for preparation of phenytoin, nifedipine or cyclosporine-loaded PLGA microspheres, using an oil-in-water emulsification technique. The drug-loaded microspheres were delivered to periodontal defects created on alveolar ridges mesial to the first maxillary molars of Sprague-Dawley rats. After eight weeks, the operation area in each rat, including the maxillary molars and periodontal tissues, was harvested and evaluated by micro-computed tomography, histochemical and immunohistochemical analyses.
Results
Physical parameters representative of periodontal regeneration, including the length of new alveolar bone (p < 0.01) and the area of new alveolar bone (p < 0.01) were significantly improved in the phenytoin group. Compared to other groups, the phenytoin group demonstrated increased expression of COL-1, VEGF-A, osteoblast and osteoclast markers (BMP-2, TGF-β1, OCN and TRAP staining), as well as decreased expression of MMP-8.
Conclusions
Results of the present study provided new evidence that localized, controlled release of phenytoin confers therapeutic benefits toward gingival recession and alveolar bone loss. Phenytoin appears to be a promising drug that promotes periodontal regeneration.
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Flu shot myths debunked
Another myth is that people with egg allergies can't get the flu vaccine. (Source: ABC News: Health)
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Flu shot myths debunked
Another myth is that people with egg allergies can't get the flu vaccine. (Source: ABC News: Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Flu shot myths debunked
Another myth is that people with egg allergies can't get the flu vaccine. (Source: ABC News: Health)
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Flu shot myths debunked
Another myth is that people with egg allergies can't get the flu vaccine. (Source: ABC News: Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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An MBT domain containing anti-lipopolysaccharide factor (PtALF8) from Portunus trituberculatus is involved in immune response to bacterial challenge
Publication date: Available online 6 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Xiaodong Wu, Yanwei Huang, Zuoben Yu, Changkao Mu, Weiwei Song, Ronghua Li, Lei Liu, Yangfang Ye, Ce Shi, Chunlin WangAbstractAnti-lipopolysaccharide factors are effective antimicrobial peptides that can bind and neutralize lipopolysaccharide (LPS). In the present study, a new sequence encoding for ALF (designated as PtALF8) was cloned by suppression subtractive hybridization method using ovary of swimming crab Portunus trituberculatus as material. The full-length cDNA of PtALF8 consisted of 531 bp with an ORF of 348 bp encoding a peptide of 115 amino acids containing a putative signal peptide of 19 amino acids. The mature PtALF8 had a predicted molecular weight (MW) of 11.28 kDa and theoretica...
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Responses of Mytilus galloprovincialis to challenge with the emerging marine pathogen Vibrio coralliilyticus
Publication date: Available online 6 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Teresa Balbi, Manon Auguste, Katia Cortese, Michele Montagna, Alessio Borello, Carla Pruzzo, Luigi Vezzulli, Laura CanesiAbstractVibrio coralliilyticus has emerged as a coral pathogen of concern throughout the Indo-Pacific reef. The interest towards understanding its ecology and pathogenic potential has increased since V. coralliilyticus was shown to be strongly virulent also for other species; in particular, it represents a serious threat for bivalve aquaculture, being one of the most important emerging pathogen responsible for oyster larval mortalities worldwide. V. coralliilyticus has a tightly regulated temperature-dependent virulence and it has been related to mass mortalities events of bent...
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IgM and IgD heavy chains of yellow catfish (Pelteobagrus fulvidraco): Molecular cloning, characterization and expression analysis in response to bacterial infection
In this study, the complete cDNA sequences of IgM and IgD heavy chains were cloned and analyzed from yellow catfish (Pelteobagrus fulvidraco). The full-length cDNA of Pf-IgM and Pf-IgD heavy chains contained an open reading frame (ORF) of 1710 and 2991 bp encoding a predicted protein of 570 and 997 amino acids, respectively. Tissue-specific expression analysis indicated that both IgM and IgD were highly expressed in kidney and spleen, and higher expression levels were found at zygote and 13th day post hatching during early development. Multiple sequence alignment and phylogenetic analysis showed IgM and IgD of yellow catfish are closely related to other fish of Siluriformes. Moreover, we also constructed the infection model of yellow catfish with bacteria (Flavobacterium columnare G4) for ...
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Oral delivery of Bacillus subtilis spores expressing grass carp reovirus VP4 protein produces protection against grass carp reovirus infection
In this study, we used B. subtilis spores as the oral delivery system and successfully constructed the B. subtilis CotC-VP4 recombinant spores (CotC-VP4 spores) to evaluate its protective efficacy in grass carp. Grass carp orally immunized with CotC-VP4 spores showed a survival rate of 57% and the relative percent survival (RPS) of 47% after the viral challenge. Further, the specific IgM levels in serum and the specific IgZ levels in intestinal mucus were significantly higher in the CotC-VP4 group than those in the Naive group. The immune-related genes including three innate immune-related genes (IL-4/13A, IL-4/13B, CSF1R), four adaptive immune-related genes (BAFF, CD4L, MHC-II, CD8), three inflammation-related genes (IL-1β, TNF-α, TGF-β) and interferon type I (IFN-I) related signaling ...
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Two novel serine proteases from Scylla paramamosain involved in the synthesis of anti-lipopolysaccharide factors and activation of prophenoloxidase system
In this study, SP3 and SP5 of mud crab (Scylla paramamosain) were studied. SP3 and SP5 were expressed in all examined tissues (mainly in hemocytes), and are associated with the immune responses of mud crab to Vibrio parahemolyticus and Staphylococcus aureus, as well as interacted with TRAF6, and are involved in the activation of anti-lipopolysaccharide factors (ALFs) probably through the TLR/NF-κB pathway. Depletion of SP3 inhibited the expression of ALF1, ALF2, ALF3, and ALF6, while knockdown of SP5 significantly decreased ALF5, and ALF6. Furthermore, both SP5 and TRAF6 regulated the PO activity in the hemolymph of mud crab. Overexpression assay showed that both SP3 and SP5 could enhance the promoter activities of ALFs in mud crab. Taken together, the results of this study indicate that ...
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Identification and characterization of a carboxypeptidase N1 from red lip mullet (Liza haematocheila); revealing its immune relevance
Publication date: Available online 6 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): N.C.N. Perera, G.I. Godahewa, Sumi Jung, Myoung-Jin Kim, Bo-Hye Nam, Jehee LeeAbstractComplement system orchestrates the innate and adaptive immunity via the activation, recruitment, and regulation of immune molecules to destroy pathogens. However, regulation of the complement is essential to avoid injuries to the autologous tissues. The present study unveils the characteristic features of an important complement component, anaphylatoxin inactivator from red lip mullet at its molecular and functional level. Mullet carboxypeptidase N1 (MuCPN1) cDNA sequence possessed an open reading frame of 1347 bp, which encoded a protein of 449 amino acids with a predicted molecular weight of 51 kDa. In silic...
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Effects of glycinin and β-conglycinin on growth performance and intestinal health in juvenile Chinese mitten crabs (Eriocheir sinensis)
This study investigates the effects of two soybean antigens (glycinin and β-conglycinin) as an antinutritional substance in the diet on the growth, digestive ability, intestinal health and microbiota of juvenile Chinese mitten crabs (Eriocheir sinensis). The isonitrogenous and isolipidic diets contained two soybean antigens at two levels each (70 and 140 g/kg β-conglycinin, 80 and 160 g/kg glycinin) and a control diet without β-conglycinin or glycinin supplementation, and were used respectively to feed juvenile E. sinensis for seven weeks. Dietary inclusion of either glycinin or β-conglycinin significantly reduced crab survival and weight gain. The crabs fed diets containing soybean antigens had higher malondialdehyde concentrations and lower catalase activities in the intestine th...
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Adherence to medication in children and adolescents with asthma: methods for monitoring and intervention.
Authors: Pearce CJ, Fleming L Abstract INTRODUCTION: Poor adherence in children with asthma is a major cause of asthma attacks and poor control, leads to large healthcare costs and has been identified as a factor in asthma deaths. However, it is difficult to detect and frequently overlooked leading to inappropriate escalation of asthma treatment. There is a need for cost effective ways to monitor adherence in order to intervene to change this modifiable behaviour. Areas Covered: Several measurement tools have been developed to assess adherence in adults and children with asthma. The current methods for measuring adherence, both subjective and objective, have several flaws and even the current gold standard, electronic monitoring devices (EMDs), has limitations. This review will out...
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Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus: A crucial role for aryl hydrocarbon receptor.
Authors: Mohammadi S, Memarian A, Sedighi S, Behnampour N, Yazdani Y Abstract Macrophages are versatile phagocytic cells in immune system with immunoregulatory functions. However, the removal of apoptotic cells by macrophages is disturbed in systemic lupus erythematosus (SLE). Aryl hydrocarbon receptor (AhR) is a ligand-activated cytoplasmic receptor and transcription factor with diverse effects on immune response. Indole-3-carbinol (I3C) is an AhR agonist which has been implicated as a beneficial factor in regulating inflammation and cytokine expression in murine models of SLE. However, the molecular mechanisms are not thoroughly studied. Here, we aimed to investigate the ex vivo effects of I3C on polarization of monocyte-derived macrophages (MDMs) in SLE patients and the expressi...
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An MBT domain containing anti-lipopolysaccharide factor (PtALF8) from Portunus trituberculatus is involved in immune response to bacterial challenge
Publication date: Available online 6 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Xiaodong Wu, Yanwei Huang, Zuoben Yu, Changkao Mu, Weiwei Song, Ronghua Li, Lei Liu, Yangfang Ye, Ce Shi, Chunlin WangAbstractAnti-lipopolysaccharide factors are effective antimicrobial peptides that can bind and neutralize lipopolysaccharide (LPS). In the present study, a new sequence encoding for ALF (designated as PtALF8) was cloned by suppression subtractive hybridization method using ovary of swimming crab Portunus trituberculatus as material. The full-length cDNA of PtALF8 consisted of 531 bp with an ORF of 348 bp encoding a peptide of 115 amino acids containing a putative signal peptide of 19 amino acids. The mature PtALF8 had a predicted molecular weight (MW) of 11.28 kDa and theoretica...
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Responses of Mytilus galloprovincialis to challenge with the emerging marine pathogen Vibrio coralliilyticus
Publication date: Available online 6 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Teresa Balbi, Manon Auguste, Katia Cortese, Michele Montagna, Alessio Borello, Carla Pruzzo, Luigi Vezzulli, Laura CanesiAbstractVibrio coralliilyticus has emerged as a coral pathogen of concern throughout the Indo-Pacific reef. The interest towards understanding its ecology and pathogenic potential has increased since V. coralliilyticus was shown to be strongly virulent also for other species; in particular, it represents a serious threat for bivalve aquaculture, being one of the most important emerging pathogen responsible for oyster larval mortalities worldwide. V. coralliilyticus has a tightly regulated temperature-dependent virulence and it has been related to mass mortalities events of bent...
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IgM and IgD heavy chains of yellow catfish (Pelteobagrus fulvidraco): Molecular cloning, characterization and expression analysis in response to bacterial infection
In this study, the complete cDNA sequences of IgM and IgD heavy chains were cloned and analyzed from yellow catfish (Pelteobagrus fulvidraco). The full-length cDNA of Pf-IgM and Pf-IgD heavy chains contained an open reading frame (ORF) of 1710 and 2991 bp encoding a predicted protein of 570 and 997 amino acids, respectively. Tissue-specific expression analysis indicated that both IgM and IgD were highly expressed in kidney and spleen, and higher expression levels were found at zygote and 13th day post hatching during early development. Multiple sequence alignment and phylogenetic analysis showed IgM and IgD of yellow catfish are closely related to other fish of Siluriformes. Moreover, we also constructed the infection model of yellow catfish with bacteria (Flavobacterium columnare G4) for ...
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Oral delivery of Bacillus subtilis spores expressing grass carp reovirus VP4 protein produces protection against grass carp reovirus infection
In this study, we used B. subtilis spores as the oral delivery system and successfully constructed the B. subtilis CotC-VP4 recombinant spores (CotC-VP4 spores) to evaluate its protective efficacy in grass carp. Grass carp orally immunized with CotC-VP4 spores showed a survival rate of 57% and the relative percent survival (RPS) of 47% after the viral challenge. Further, the specific IgM levels in serum and the specific IgZ levels in intestinal mucus were significantly higher in the CotC-VP4 group than those in the Naive group. The immune-related genes including three innate immune-related genes (IL-4/13A, IL-4/13B, CSF1R), four adaptive immune-related genes (BAFF, CD4L, MHC-II, CD8), three inflammation-related genes (IL-1β, TNF-α, TGF-β) and interferon type I (IFN-I) related signaling ...
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Two novel serine proteases from Scylla paramamosain involved in the synthesis of anti-lipopolysaccharide factors and activation of prophenoloxidase system
In this study, SP3 and SP5 of mud crab (Scylla paramamosain) were studied. SP3 and SP5 were expressed in all examined tissues (mainly in hemocytes), and are associated with the immune responses of mud crab to Vibrio parahemolyticus and Staphylococcus aureus, as well as interacted with TRAF6, and are involved in the activation of anti-lipopolysaccharide factors (ALFs) probably through the TLR/NF-κB pathway. Depletion of SP3 inhibited the expression of ALF1, ALF2, ALF3, and ALF6, while knockdown of SP5 significantly decreased ALF5, and ALF6. Furthermore, both SP5 and TRAF6 regulated the PO activity in the hemolymph of mud crab. Overexpression assay showed that both SP3 and SP5 could enhance the promoter activities of ALFs in mud crab. Taken together, the results of this study indicate that ...
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Identification and characterization of a carboxypeptidase N1 from red lip mullet (Liza haematocheila); revealing its immune relevance
Publication date: Available online 6 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): N.C.N. Perera, G.I. Godahewa, Sumi Jung, Myoung-Jin Kim, Bo-Hye Nam, Jehee LeeAbstractComplement system orchestrates the innate and adaptive immunity via the activation, recruitment, and regulation of immune molecules to destroy pathogens. However, regulation of the complement is essential to avoid injuries to the autologous tissues. The present study unveils the characteristic features of an important complement component, anaphylatoxin inactivator from red lip mullet at its molecular and functional level. Mullet carboxypeptidase N1 (MuCPN1) cDNA sequence possessed an open reading frame of 1347 bp, which encoded a protein of 449 amino acids with a predicted molecular weight of 51 kDa. In silic...
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Effects of glycinin and β-conglycinin on growth performance and intestinal health in juvenile Chinese mitten crabs (Eriocheir sinensis)
This study investigates the effects of two soybean antigens (glycinin and β-conglycinin) as an antinutritional substance in the diet on the growth, digestive ability, intestinal health and microbiota of juvenile Chinese mitten crabs (Eriocheir sinensis). The isonitrogenous and isolipidic diets contained two soybean antigens at two levels each (70 and 140 g/kg β-conglycinin, 80 and 160 g/kg glycinin) and a control diet without β-conglycinin or glycinin supplementation, and were used respectively to feed juvenile E. sinensis for seven weeks. Dietary inclusion of either glycinin or β-conglycinin significantly reduced crab survival and weight gain. The crabs fed diets containing soybean antigens had higher malondialdehyde concentrations and lower catalase activities in the intestine th...
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Adherence to medication in children and adolescents with asthma: methods for monitoring and intervention.
Authors: Pearce CJ, Fleming L Abstract INTRODUCTION: Poor adherence in children with asthma is a major cause of asthma attacks and poor control, leads to large healthcare costs and has been identified as a factor in asthma deaths. However, it is difficult to detect and frequently overlooked leading to inappropriate escalation of asthma treatment. There is a need for cost effective ways to monitor adherence in order to intervene to change this modifiable behaviour. Areas Covered: Several measurement tools have been developed to assess adherence in adults and children with asthma. The current methods for measuring adherence, both subjective and objective, have several flaws and even the current gold standard, electronic monitoring devices (EMDs), has limitations. This review will out...
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Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus: A crucial role for aryl hydrocarbon receptor.
Authors: Mohammadi S, Memarian A, Sedighi S, Behnampour N, Yazdani Y Abstract Macrophages are versatile phagocytic cells in immune system with immunoregulatory functions. However, the removal of apoptotic cells by macrophages is disturbed in systemic lupus erythematosus (SLE). Aryl hydrocarbon receptor (AhR) is a ligand-activated cytoplasmic receptor and transcription factor with diverse effects on immune response. Indole-3-carbinol (I3C) is an AhR agonist which has been implicated as a beneficial factor in regulating inflammation and cytokine expression in murine models of SLE. However, the molecular mechanisms are not thoroughly studied. Here, we aimed to investigate the ex vivo effects of I3C on polarization of monocyte-derived macrophages (MDMs) in SLE patients and the expressi...
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Optimization of Cochlear Implant MAP-parameters in Children
Conditions: Cochlear Implants; Evoked Potentials, Auditory; Child; Disabilities Hearing; Deafness; Hearing Intervention: Other: Re-programming of cochlear implant Sponsors: Göteborg University; Vastra Gotaland Region Not yet recruiting (Source: ClinicalTrials.gov)
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Study of Auditory Performance on Prosodic Tests in Cochlear Implanted Subjects Using a Fine Structure Strategy
Condition: Sensorineural Hearing Loss, Bilateral Intervention: Device: FineHearing strategy Sponsor: Med-El Elektromedizinische Geraete GmbH Not yet recruiting (Source: ClinicalTrials.gov)
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Study of Auditory Performance on Prosodic Tests in Cochlear Implanted Subjects Using a Fine Structure Strategy
Condition: Sensorineural Hearing Loss, Bilateral Intervention: Device: FineHearing strategy Sponsor: Med-El Elektromedizinische Geraete GmbH Not yet recruiting (Source: ClinicalTrials.gov)
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Optimization of Cochlear Implant MAP-parameters in Children
Conditions: Cochlear Implants; Evoked Potentials, Auditory; Child; Disabilities Hearing; Deafness; Hearing Intervention: Other: Re-programming of cochlear implant Sponsors: Göteborg University; Vastra Gotaland Region Not yet recruiting (Source: ClinicalTrials.gov)
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Optimization of Cochlear Implant MAP-parameters in Children
Conditions: Cochlear Implants; Evoked Potentials, Auditory; Child; Disabilities Hearing; Deafness; Hearing Intervention: Other: Re-programming of cochlear implant Sponsors: Göteborg University; Vastra Gotaland Region Not yet recruiting (Source: ClinicalTrials.gov)
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Study of Auditory Performance on Prosodic Tests in Cochlear Implanted Subjects Using a Fine Structure Strategy
Condition: Sensorineural Hearing Loss, Bilateral Intervention: Device: FineHearing strategy Sponsor: Med-El Elektromedizinische Geraete GmbH Not yet recruiting (Source: ClinicalTrials.gov)
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Study of Auditory Performance on Prosodic Tests in Cochlear Implanted Subjects Using a Fine Structure Strategy
Condition: Sensorineural Hearing Loss, Bilateral Intervention: Device: FineHearing strategy Sponsor: Med-El Elektromedizinische Geraete GmbH Not yet recruiting (Source: ClinicalTrials.gov)
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Optimization of Cochlear Implant MAP-parameters in Children
Conditions: Cochlear Implants; Evoked Potentials, Auditory; Child; Disabilities Hearing; Deafness; Hearing Intervention: Other: Re-programming of cochlear implant Sponsors: Göteborg University; Vastra Gotaland Region Not yet recruiting (Source: ClinicalTrials.gov)
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FLUAD vs. FLUZONE HD Influenza Vaccine in Residents of Long Term Care
Condition: Flu Interventions: Drug: Fluad Vaccine; Drug: Fluzone HD Vaccine Sponsors: David H. Canaday; Case Western Reserve University; US Department of Veterans Affairs; Brown University; National Institutes of Health (NIH); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Food Allergy Diagnostic Test Response to Previous Oral Challenge Response
Condition: Food Hypersensitivity Intervention: Other: Conjunctival Allergen Challenge Sponsor: ORA, Inc. Completed (Source: ClinicalTrials.gov)
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FLUAD vs. FLUZONE HD Influenza Vaccine in Residents of Long Term Care
Condition: Flu Interventions: Drug: Fluad Vaccine; Drug: Fluzone HD Vaccine Sponsors: David H. Canaday; Case Western Reserve University; US Department of Veterans Affairs; Brown University; National Institutes of Health (NIH); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Food Allergy Diagnostic Test Response to Previous Oral Challenge Response
Condition: Food Hypersensitivity Intervention: Other: Conjunctival Allergen Challenge Sponsor: ORA, Inc. Completed (Source: ClinicalTrials.gov)
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Implementing a Software Solution across Multiple Ultrasound Vendors to Auto-fill Reports with Measurement Values
Publication date: Available online 7 October 2018
Source: Current Problems in Diagnostic Radiology
Author(s): Meir H Scheinfeld, Oleg Kaplun, Neville A Simmons, Jonathan Sterman, Shlomit Goldberg-Stein
Abstract
Reliable transmission of ultrasound measurements into radiology reports is fraught with potential sources of error. In a conventional workflow, measurements are either written by hand on worksheets and/or dictated from worksheets or the images themselves into the radiology report. Valuable physician time is spent dictating, checking and editing these values and this process is error-prone. Our approach was to use a transfer-software application to auto-populate measurements, with a goal of achieving >90% utilization rate by both technologists and radiologists. Implementation involved creating measurement fields for each measurement on each ultrasound unit of our multi-site academic department. These fields were then mapped in both the transfer-software and the dictation software, to set up a 1:1:1 correspondence for each field. As a result, each measurement acquired by the technologist would automatically populate the radiology report within the dictation software. We created and mapped 128 fields for 39 exam templates. After implementation, technologist utilization rate was 86-96% and overall radiologist utilization rate was 92-93%. Radiology resident utilization rate was highest, at 95-96%. We provide a guide for implementation and lessons learned.
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Case report on recovery from Japanese encephalitis virus infection by complementary use of phytolacca-mother tincture and in silico analysis
Publication date: Available online 6 October 2018
Source: Journal of Herbal Medicine
Author(s): Harish Chandra Chaudhury, Akhil Kumar Panda, Sarat Kumar Behera, Manjushree Mohanty, Bharat Bhusan Subudhi
Abstract
Phytolacca Americana L
or pokeweed has medicinal application against inflammation, arthritis, and viral fever infections in traditional medicines. Its mother tincture in the homeopathic system of medicine is used for many of these disease conditions. This is the first case study reporting the beneficial effects of Phytolacca-mother tincture against Japanese Encephalitis Virus (JEV) infection in an intensive care unit (ICU) patient. A 42-year-old male patient with JEV infection failed to respond to conventional therapy. Following this, he was administered pokeweed tincture orally, two drops three times daily along with conventional therapy. Gradually the patient recovered and after two months of treatment, the patient was discharged with neurological sequelae. The anti-JEV basis of pokeweed was investigated by in silico analysis. The antiviral protein of pokeweed which has earlier been reported to inhibit viral RNA synthesis was shown to have the affinity for nonstructural protein (NS5) of JEV by use of protein-protein docking. Esculentic acid of pokeweed was also predicted to have a strong affinity for NS3 and NS5 of JEV. It was also found to be a potent inhibitor of multiple targets which have the potential to mediate antiviral action. Considering the possibilities of both direct and indirect interferences of pokeweed phytoconstituents with JEV proteins, it can be suggested that pokeweed mother tincture can be a good complementary antiviral therapy against JEV infection.
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Implementing a Software Solution across Multiple Ultrasound Vendors to Auto-fill Reports with Measurement Values
Publication date: Available online 7 October 2018
Source: Current Problems in Diagnostic Radiology
Author(s): Meir H Scheinfeld, Oleg Kaplun, Neville A Simmons, Jonathan Sterman, Shlomit Goldberg-Stein
Abstract
Reliable transmission of ultrasound measurements into radiology reports is fraught with potential sources of error. In a conventional workflow, measurements are either written by hand on worksheets and/or dictated from worksheets or the images themselves into the radiology report. Valuable physician time is spent dictating, checking and editing these values and this process is error-prone. Our approach was to use a transfer-software application to auto-populate measurements, with a goal of achieving >90% utilization rate by both technologists and radiologists. Implementation involved creating measurement fields for each measurement on each ultrasound unit of our multi-site academic department. These fields were then mapped in both the transfer-software and the dictation software, to set up a 1:1:1 correspondence for each field. As a result, each measurement acquired by the technologist would automatically populate the radiology report within the dictation software. We created and mapped 128 fields for 39 exam templates. After implementation, technologist utilization rate was 86-96% and overall radiologist utilization rate was 92-93%. Radiology resident utilization rate was highest, at 95-96%. We provide a guide for implementation and lessons learned.
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Case report on recovery from Japanese encephalitis virus infection by complementary use of phytolacca-mother tincture and in silico analysis
Publication date: Available online 6 October 2018
Source: Journal of Herbal Medicine
Author(s): Harish Chandra Chaudhury, Akhil Kumar Panda, Sarat Kumar Behera, Manjushree Mohanty, Bharat Bhusan Subudhi
Abstract
Phytolacca Americana L
or pokeweed has medicinal application against inflammation, arthritis, and viral fever infections in traditional medicines. Its mother tincture in the homeopathic system of medicine is used for many of these disease conditions. This is the first case study reporting the beneficial effects of Phytolacca-mother tincture against Japanese Encephalitis Virus (JEV) infection in an intensive care unit (ICU) patient. A 42-year-old male patient with JEV infection failed to respond to conventional therapy. Following this, he was administered pokeweed tincture orally, two drops three times daily along with conventional therapy. Gradually the patient recovered and after two months of treatment, the patient was discharged with neurological sequelae. The anti-JEV basis of pokeweed was investigated by in silico analysis. The antiviral protein of pokeweed which has earlier been reported to inhibit viral RNA synthesis was shown to have the affinity for nonstructural protein (NS5) of JEV by use of protein-protein docking. Esculentic acid of pokeweed was also predicted to have a strong affinity for NS3 and NS5 of JEV. It was also found to be a potent inhibitor of multiple targets which have the potential to mediate antiviral action. Considering the possibilities of both direct and indirect interferences of pokeweed phytoconstituents with JEV proteins, it can be suggested that pokeweed mother tincture can be a good complementary antiviral therapy against JEV infection.
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γδ T cells amplify Blomia tropicalis‐induced allergic airway disease
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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Legends of Allergy: Carla Bruijnzeel ‐Koomen
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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γδ T cells amplify Blomia tropicalis‐induced allergic airway disease
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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Legends of Allergy: Carla Bruijnzeel ‐Koomen
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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Effects of intraarticular tramadol, magnesium and ketamine on postoperative pain in arthroscopic meniscectomy
Publication date: Available online 6 October 2018
Source: Brazilian Journal of Anesthesiology (English Edition)
Author(s): Nevriye Salman, Bilge Olgunkeleş, Umut Bektaş, Derviş Güner, Meltem Bektas, Şadan Ay, Sumru Şekerci
Abstract
Objective
Postoperative pain control is important in terms of early recovery and rehabilitation in arthroscopic meniscectomy. For this purpose, we aimed to compare the effects of intraarticular tramadol, magnesium, and ketamine with combinations of pericapsular bupivacaine on postoperative pain and recovery in arthroscopic meniscectomy.
Methods
Ninety patients who underwent arthroscopic meniscectomy were enrolled in the study. Group T was given tramadol, Group K was given ketamine, and Group M was given magnesium reconstituted intraarticularly, and all groups received periarticular bupivacaine. Comparisons were made in terms of the patients' postoperative Visual Analogue Scale scores with and without movement, need for additional analgesics, first analgesic time, mobilization times, adverse effects, and satisfaction with the analgesics.
Results
The Visual Analogue Scale scores were lowest in Group T at 0 minutes, and were higher in the 15th and 30th minutes and 1st, 2nd, and 6th hours. Visual Analogue Scale values with movement were found to be high in Group M at 0 and 15 minutes, but they were found to be higher in group T in the 30th minute, 1st, 2nd and 6th hour. The groups were similar in terms of postoperative additional analgesic use, number of analgesic use, and satisfaction with analgesics; however, the first analgesic time was earlier in Group M, and the first mobilization time was earlier in Group K.
Conclusion
Intraarticular ketamine enables early mobilization and less need for additional analgesics, it also provides a better analgesic effect in comparison with intraarticular tramadol and magnesium.
Resumo
Objetivo
O controle da dor pós-operatória é importante para recuperação e reabilitação precoces em meniscectomia artroscópica. Portanto, nosso objetivo foi comparar os efeitos de tramadol, magnésio e cetamina administrados por via intra-articular em associação com bupivacaína pericapsular sobre a dor e a recuperação após meniscectomia artroscópica.
Métodos
Noventa pacientes submetidos à meniscectomia artroscópica foram incluídos no estudo. O Grupo T recebeu tramadol, o Grupo K recebeu cetamina e o Grupo M recebeu magnésio em doses reconstituídas por via intra-articular e todos os grupos receberam bupivacaína por via periarticular. As avaliações foram feitas mediante comparação dos escores em escala visual analógica no pós-operatório dos pacientes em movimento e em repouso, necessidade de analgésicos adicionais, tempo até a primeira necessidade de analgésico, tempo de mobilização, efeitos adversos e satisfação com os analgésicos.
Resultados
Os escores da escala visual analógica foram menores no minuto zero e maiores nos minutos 15 e 30 e nas horas 1, 2 e 6 no Grupo T. Os escores da escala visual analógica em movimento foram maiores nos minutos zero e 15 no Grupo M e maiores no minuto 30 e nas horas 1, 2 e 6 no Grupo T. Os escores dos grupos foram semelhantes em relação à necessidade de analgésico adicional no pós-operatório, ao consumo de analgésico e à satisfação com os analgésicos, mas os tempos até a primeira necessidade de analgesia e até a primeira mobilização foram mais curtos nos grupos M e K, respectivamente.
Conclusão
A administração intra-articular de cetamina permite mobilização precoce e diminui a necessidade de analgésicos adicionais, além de proporcionar um melhor efeito analgésico em comparação com tramadol e magnésio por via intra-articular.
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Transthoracic echocardiographic assessment of cardiac output in mechanically ventilated critically ill patients by intensive care unit physicians
Publication date: Available online 6 October 2018
Source: Brazilian Journal of Anesthesiology (English Edition)
Author(s): Valentina Bergamaschi, Gian Luca Vignazia, Antonio Messina, Davide Colombo, Gianmaria Cammarota, Francesco Della Corte, Egidio Traversi, Paolo Navalesi
Abstract
Background and objectives
Transthoracic echocardiography may potentially be useful to obtain a prompt, accurate and non-invasive estimation of cardiac output. We evaluated whether non-cardiologist intensivists may obtain accurate and reproducible cardiac output determination in hemodynamically unstable mechanically ventilated patients.
Methods
We studied 25 hemodynamically unstable mechanically ventilated intensive care unit patients with a pulmonary artery catheter in place. Cardiac output was calculated using the pulsed Doppler transthoracic echocardiography technique applied to the left ventricular outflow tract in apical 5 chamber view by two intensive care unit physicians who had received a basic Transthoracic Echocardiography training plus a specific training focused on Doppler, left ventricular outflow tract and velocity-time integral determination.
Results
Cardiac output assessment by transthoracic echocardiography was feasible in 20 out of 25 enrolled patients (80%) and showed an excellent inter-operator reproducibility (Pearson correlation test r = 0.987; Cohen's K = 0.840). Overall, the mean bias was 0.03 L.min−1, with limits of agreement −0.52 and +0.57 L.min−1. The concordance correlation coefficient (ρc) was 0.986 (95% IC 0.966–0.995) and 0.995 (95% IC 0.986–0.998) for physician 1 and 2, respectively. The value of accuracy (Cb) of COTTE measurement was 0.999 for both observers. The value of precision (ρ) of COTTE measurement was 0.986 and 0.995 for observer 1 and 2, respectively.
Conclusions
A specific training focused on Doppler and VTI determination added to the standard basic transthoracic echocardiography training allowed non-cardiologist intensive care unit physicians to achieve a quick, reproducible and accurate snapshot cardiac output assessment in the majority of mechanically ventilated intensive care unit patients.
Resumo
Justificativa e objetivos
A ecocardiografia transtorácica pode ser potencialmente útil para obter uma estimativa rápida, precisa e não invasiva do débito cardíaco. Avaliamos se os intensivistas não cardiologistas podem obter uma determinação precisa e reprodutível do débito cardíaco em pacientes mecanicamente ventilados e hemodinamicamente instáveis.
Métodos
Avaliamos 25 pacientes em unidade de terapia intensiva, mecanicamente ventilados, hemodinamicamente instáveis, com cateteres de artéria pulmonar posicionados. O débito cardíaco foi calculado usando a técnica de ecocardiografia transtorácica com Doppler pulsátil aplicada à via de saída do ventrículo esquerdo no corte apical (5-câmaras) por dois médicos intensivistas que receberam treinamento básico em ecocardiografia transtorácica e treinamento específico focado em Doppler, via de saída do ventrículo esquerdo e determinação da integral de tempo-velocidade.
Resultados
A avaliação do débito cardíaco pelo ecocardiograma transtorácico foi factível em 20 dos 25 pacientes inscritos (80%) e mostrou excelente reprodutibilidade entre operadores (teste de correlação de Pearson r = 0,987; K de Cohen = 0,840). No geral, o viés médio foi de 0,03 L.min−1, com limites de concordância de −0,52 e +0,57 L.min−1. O coeficiente de correlação de concordância (ρc) foi 0,986 (95% IC 0,966–0,995) e 0,995 (95% IC 0,986–0,998) para os médicos 1 e 2, respectivamente. O valor de precisão (Cb) da mensuração de COTTE foi de 0,999 para ambos os observadores. O valor de precisão (ρ) da mensuração de COTTE foi de 0,986 e 0,995 para os observadores 1 e 2, respectivamente.
Conclusões
Um treinamento específico focado na determinação do Doppler e VTI, adicionado ao treinamento padrão em ecocardiografia transtorácica básica, permitiu que médicos não cardiologistas da unidade de terapia intensiva obtivessem uma avaliação rápida, reprodutível e precisa do débito cardíaco instantâneo na maioria dos pacientes mecanicamente ventilados em unidade de terapia intensiva.
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