Epicutaneous immunotherapy for peanut allergy modifies IgG4 responses to major peanut allergens

This study shows that EPIT induces IgG4 to the major peanut allergens, Ara h 1, h 2, h 3 and h 6. (Source: Journal of Allergy and Clinical Immunology)

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Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy

Wheat is a common food allergen that can cause anaphylaxis. (Source: Journal of Allergy and Clinical Immunology)

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Intracerebroventricular A β-Induced Neuroinflammation Alters Peripheral Immune Responses in Rats

AbstractAn important marker in Alzheimer disease (AD) is the abnormal production and accumulation of β-amyloid peptide (Aß) in brain. It produces oxidative damage in neurons and inflammation due to its neurotoxic properties. The present study was designed to investigate neuroinflammation (hippocampal levels of ROS, nitrite, TNF-α, and IL-1β), neurodegeneration (plaques and chromatolysis in hi ppocampus), and memory impairments (working memory and reference memory) and the effect of this neuroinflammation on some peripheral immunological parameters such as phagocytic activity of blood WBC and splenic polymorphonuclear (PMN) cells, leucocyte adhesion inhibition index (LAI), and cytotoxici ty of splenic mononuclear cells (MNC) after the intracebroventricular injection of aggregated Aβ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qiUgov

Epicutaneous immunotherapy for peanut allergy modifies IgG4 responses to major peanut allergens

This study shows that EPIT induces IgG4 to the major peanut allergens, Ara h 1, h 2, h 3 and h 6. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qlTRBM

Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy

Wheat is a common food allergen that can cause anaphylaxis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qduxti

Intracerebroventricular A β-Induced Neuroinflammation Alters Peripheral Immune Responses in Rats

AbstractAn important marker in Alzheimer disease (AD) is the abnormal production and accumulation of β-amyloid peptide (Aß) in brain. It produces oxidative damage in neurons and inflammation due to its neurotoxic properties. The present study was designed to investigate neuroinflammation (hippocampal levels of ROS, nitrite, TNF-α, and IL-1β), neurodegeneration (plaques and chromatolysis in hi ppocampus), and memory impairments (working memory and reference memory) and the effect of this neuroinflammation on some peripheral immunological parameters such as phagocytic activity of blood WBC and splenic polymorphonuclear (PMN) cells, leucocyte adhesion inhibition index (LAI), and cytotoxici ty of splenic mononuclear cells (MNC) after the intracebroventricular injection of aggregated Aβ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qiUgov

Comparative Evaluation of Immunohistochemical Expression of p16 with p16 Microsatellite Marker by PCR in Surgical Margins of Oral Squamous Cell Carcinoma

Abstract

Oral squamous cell carcinoma (OSCC) is most common oral cancer with multifactorial etiology. Surgical therapy is treatment of choice but known to have recurrence. The main reason for recurrence is associated with surgical margins which need to be tumor free. Changes at genetic level cannot be ascertained only through routine light microscopy in surgical margins, even though they are tumor free. Detection of early marker like p16 can help in predicting the risk of recurrence. Hence study aimed to detect p16 microsatellite marker (D9s1747) in surgical margins of oral squamous cell carcinoma and compare the same with p16 marker through immunohistochemistry. Total of 40 paraffin embedded tissue samples diagnosed and surgically treated cases of OSCC were included. From each sample one tumor proper and one surgical margin was obtained. From paraffin embedded tissue sample 2 sections of 4 µm thick was obtained from tumor proper and tumor margin. One section was stained with hematoxylin and eosin and other section was stained immunohistochemically using p16 antibody. DNA extraction was done for tumor proper and surgical margin tissue and PCR analysis was carried for p16 microsatellite marker (D91747). Out of 40 cases 37 cases showed positivity in tumor proper for p16 with IHC. Out of 37 cases 23 cases showed positivity for both tumor proper and surgical margin. There were 3 cases negative for tumor proper. Out of these 3 cases, 1 (33.3%) case was positive for surgical margin. Out of 40 cases 27 cases showed positivity for tumor proper with p16 microsatellite marker. Out of 27 cases 16 cases showed positivity for both tumor proper and surgical margin. There were 13 cases negative for tumor proper. However there were 8 (61.5%) cases negative which were in tumor proper but showed positivity for surgical margin. Other 5 cases were negative in both tumor proper and surgical margin. Our study reveals that surgical margins of OSCC exhibit alteration in p16 markers both by IHC and PCR techniques. p16 and p16 microsatellite marker detection in margins indicates field change. Further studies with larger sample size comparing expression with clinical and histological parameter and follow up has to be done to substantiate our findings.

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Comparative Evaluation of Immunohistochemical Expression of p16 with p16 Microsatellite Marker by PCR in Surgical Margins of Oral Squamous Cell Carcinoma

Abstract

Oral squamous cell carcinoma (OSCC) is most common oral cancer with multifactorial etiology. Surgical therapy is treatment of choice but known to have recurrence. The main reason for recurrence is associated with surgical margins which need to be tumor free. Changes at genetic level cannot be ascertained only through routine light microscopy in surgical margins, even though they are tumor free. Detection of early marker like p16 can help in predicting the risk of recurrence. Hence study aimed to detect p16 microsatellite marker (D9s1747) in surgical margins of oral squamous cell carcinoma and compare the same with p16 marker through immunohistochemistry. Total of 40 paraffin embedded tissue samples diagnosed and surgically treated cases of OSCC were included. From each sample one tumor proper and one surgical margin was obtained. From paraffin embedded tissue sample 2 sections of 4 µm thick was obtained from tumor proper and tumor margin. One section was stained with hematoxylin and eosin and other section was stained immunohistochemically using p16 antibody. DNA extraction was done for tumor proper and surgical margin tissue and PCR analysis was carried for p16 microsatellite marker (D91747). Out of 40 cases 37 cases showed positivity in tumor proper for p16 with IHC. Out of 37 cases 23 cases showed positivity for both tumor proper and surgical margin. There were 3 cases negative for tumor proper. Out of these 3 cases, 1 (33.3%) case was positive for surgical margin. Out of 40 cases 27 cases showed positivity for tumor proper with p16 microsatellite marker. Out of 27 cases 16 cases showed positivity for both tumor proper and surgical margin. There were 13 cases negative for tumor proper. However there were 8 (61.5%) cases negative which were in tumor proper but showed positivity for surgical margin. Other 5 cases were negative in both tumor proper and surgical margin. Our study reveals that surgical margins of OSCC exhibit alteration in p16 markers both by IHC and PCR techniques. p16 and p16 microsatellite marker detection in margins indicates field change. Further studies with larger sample size comparing expression with clinical and histological parameter and follow up has to be done to substantiate our findings.

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Large Cytologically Benign Thyroid Nodules Do Not Have High Rates of Malignancy or False-Negative Rates and Clinical Observation Should be Considered: A Meta-Analysis

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AB0kii

Iodine Content of the Best-Selling United States Adult and Prenatal Multivitamin Preparations

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ETp0Xu

Large Cytologically Benign Thyroid Nodules Do Not Have High Rates of Malignancy or False-Negative Rates and Clinical Observation Should be Considered: A Meta-Analysis

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AB0kii

Iodine Content of the Best-Selling United States Adult and Prenatal Multivitamin Preparations

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ETp0Xu

Large Cytologically Benign Thyroid Nodules Do Not Have High Rates of Malignancy or False-Negative Rates and Clinical Observation Should be Considered: A Meta-Analysis

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AB0kii

Iodine Content of the Best-Selling United States Adult and Prenatal Multivitamin Preparations

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ETp0Xu

Large Cytologically Benign Thyroid Nodules Do Not Have High Rates of Malignancy or False-Negative Rates and Clinical Observation Should be Considered: A Meta-Analysis

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AB0kii

Iodine Content of the Best-Selling United States Adult and Prenatal Multivitamin Preparations

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ETp0Xu

Interaction Between Pitch and Timbre Perception in Normal-Hearing Listeners and Cochlear Implant Users

This study tested the interaction between pitch and sharpness (an aspect of timbre) perception related to the fundamental frequency (F0) and spectral slope of harmonic complex tones, respectively, in both NH listeners and CI users. In experiment 1, the F0 (and spectral slope) difference limens (DLs) were measured with a fixed spectral slope (and F0) and 20-dB amplitude roving. Then, the F0 and spectral slope were varied congruently or incongruently by the same multiple of individual DLs to assess the pitch and sharpness ranking sensitivity. Both NH and CI subjects had significantly higher pitch and sharpness ranking sensitivity with congruent than with incongruent F0 and spectral slope variations, and showed a similar symmetric interaction between pitch and timbre perception. In experiment...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JqJfuh

Mammalian behavior and physiology converge to confirm sharper cochlear tuning in humans [Neuroscience]

Frequency analysis of sound by the cochlea is the most fundamental property of the auditory system. Despite its importance, the resolution of this frequency analysis in humans remains controversial. The controversy persists because the methods used to estimate tuning in humans are indirect and have not all been independently validated... (Source: Proceedings of the National Academy of Sciences)

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Treatment of ischemic stroke beyond 3 hours: is time really brain?

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SvDKym

Mammalian behavior and physiology converge to confirm sharper cochlear tuning in humans [Neuroscience]

Frequency analysis of sound by the cochlea is the most fundamental property of the auditory system. Despite its importance, the resolution of this frequency analysis in humans remains controversial. The controversy persists because the methods used to estimate tuning in humans are indirect and have not all been independently validated... (Source: Proceedings of the National Academy of Sciences)

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Treatment of ischemic stroke beyond 3 hours: is time really brain?

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SvDKym

Large Cytologically Benign Thyroid Nodules Do Not Have High Rates of Malignancy or False-Negative Rates and Clinical Observation Should be Considered: A Meta-Analysis

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zjyDsC

Iodine Content of the Best-Selling United States Adult and Prenatal Multivitamin Preparations

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SqXgfD

Iodine Content of the Best-Selling United States Adult and Prenatal Multivitamin Preparations

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SqXgfD

Immunomodulatory and ameliorative effects of Lactobacillus and Saccharomyces based probiotics on pathological effects of eimeriasis in broilers

In conclusion, supplementation of probiotics proved very useful to enhance the immunological and performance potentials of broilers which subsequently provided protection against Eimeria infection. Further studies on the physico-chemical properties along with commercial feasibility and cost benefit analysis of these probiotic species are needed for wise selection to get maximum profit from broiler industry. (Source: Microbial Pathogenesis)

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Cutaneous manifestations of primary immunodeficiency diseases in tunisian children

Abstract. Skin manifestations are frequent among patients with primary immunodeficiency diseases (PIDs). Their prevalence varies according to the type of immunodeficiency. This review provides the reader with an up-to-date summary of the common dermatologic manifestations of PIDs among Tunisian children. We conducted a prospective study on two hundred and ninety children with immune deficiency. Demographic details (including age, sex, and consanguinity) with personal and family history were recorded. Special attention was paid to cutaneous manifestations. Dermatological involvements were grouped according to the etiology of their most prominent sign. Cutaneous manifestations were found in 164 patients (56.5%). They revealed the diagnosis of PIDs in 71 patients (24.5 %). The mean age a...

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Correction to Supporting Information for Kwon et al., FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes [SI Correction]

IMMUNOLOGY AND INFLAMMATION Correction to Supporting Information for "FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes," by Ho-Keun Kwon, Hui-Min Chen, Diane Mathis, and Christophe Benoist, which was first published December 21, 2017; 10.1073/pnas.1718599115 (Proc Natl Acad Sci USA 115:E253–E262). The authors note that Datasets... (Source: Proceedings of the National Academy of Sciences)

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Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis [Immunology and Inflammation]

Pathogens, particularly human herpesviruses (HHVs), are implicated as triggers of disease onset/progression in multiple sclerosis (MS) and other neuroinflammatory disorders. However, the time between viral acquisition in childhood and disease onset in adulthood complicates the study of this association. Using nonhuman primates, we demonstrate that intranasal inoculations with HHV-6A and... (Source: Proceedings of the National Academy of Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CQRXk9

Immunomodulatory and ameliorative effects of Lactobacillus and Saccharomyces based probiotics on pathological effects of eimeriasis in broilers

In conclusion, supplementation of probiotics proved very useful to enhance the immunological and performance potentials of broilers which subsequently provided protection against Eimeria infection. Further studies on the physico-chemical properties along with commercial feasibility and cost benefit analysis of these probiotic species are needed for wise selection to get maximum profit from broiler industry. (Source: Microbial Pathogenesis)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P1MIW4

Cutaneous manifestations of primary immunodeficiency diseases in tunisian children

Abstract. Skin manifestations are frequent among patients with primary immunodeficiency diseases (PIDs). Their prevalence varies according to the type of immunodeficiency. This review provides the reader with an up-to-date summary of the common dermatologic manifestations of PIDs among Tunisian children. We conducted a prospective study on two hundred and ninety children with immune deficiency. Demographic details (including age, sex, and consanguinity) with personal and family history were recorded. Special attention was paid to cutaneous manifestations. Dermatological involvements were grouped according to the etiology of their most prominent sign. Cutaneous manifestations were found in 164 patients (56.5%). They revealed the diagnosis of PIDs in 71 patients (24.5 %). The mean age a...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CRaNrj

Correction to Supporting Information for Kwon et al., FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes [SI Correction]

IMMUNOLOGY AND INFLAMMATION Correction to Supporting Information for "FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes," by Ho-Keun Kwon, Hui-Min Chen, Diane Mathis, and Christophe Benoist, which was first published December 21, 2017; 10.1073/pnas.1718599115 (Proc Natl Acad Sci USA 115:E253–E262). The authors note that Datasets... (Source: Proceedings of the National Academy of Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OXjuro

Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis [Immunology and Inflammation]

Pathogens, particularly human herpesviruses (HHVs), are implicated as triggers of disease onset/progression in multiple sclerosis (MS) and other neuroinflammatory disorders. However, the time between viral acquisition in childhood and disease onset in adulthood complicates the study of this association. Using nonhuman primates, we demonstrate that intranasal inoculations with HHV-6A and... (Source: Proceedings of the National Academy of Sciences)

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FDA May Require Products to List Sesame Allergen

Research suggests that more than 300,000 Americans have sesame allergy, according to Lisa Gable, CEO of the nonprofit group Food Allergy Research and Education. (Source: WebMD Health)

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Building Tolerance Helps Kids With Wheat Allergy

TUESDAY, Oct. 30, 2018 -- Giving trace amounts of wheat to children with wheat allergy shows promise in treating the allergy, according to new research. The researchers started with 46 wheat-allergic children, average age about 9 years, and gave... (Source: Drugs.com - Daily MedNews)

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FDA May Require Products to List Sesame Allergen

Research suggests that more than 300,000 Americans have sesame allergy, according to Lisa Gable, CEO of the nonprofit group Food Allergy Research and Education. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Building Tolerance Helps Kids With Wheat Allergy

TUESDAY, Oct. 30, 2018 -- Giving trace amounts of wheat to children with wheat allergy shows promise in treating the allergy, according to new research. The researchers started with 46 wheat-allergic children, average age about 9 years, and gave... (Source: Drugs.com - Daily MedNews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JqJ9Tr

Evaluation of folded amniotic membrane and injectable amniotic membrane pieces as soft tissue filler materials

The search for safe and effective tissue fillers has been an ongoing effort for many years. Obtaining biological materials from patients can require additional incisions and brings surgical and cosmetic risks as a major disadvantage. The aim of this experimental study was, therefore, to evaluate the efficacy of folded amniotic membrane as a soft tissue filler and to assess its volume, and to investigate the possible usage of injectable amniotic membrane for augmentation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P2kevu

Migraine increases the proportion of sudden sensorineural hearing loss: A longitudinal follow-up study

The aim of the present study was to investigate the proportion of sudden sensorineural hearing loss (SSNHL) patients in a representative population cohort with migraine.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CT0gf9

Evaluation of folded amniotic membrane and injectable amniotic membrane pieces as soft tissue filler materials

The search for safe and effective tissue fillers has been an ongoing effort for many years. Obtaining biological materials from patients can require additional incisions and brings surgical and cosmetic risks as a major disadvantage. The aim of this experimental study was, therefore, to evaluate the efficacy of folded amniotic membrane as a soft tissue filler and to assess its volume, and to investigate the possible usage of injectable amniotic membrane for augmentation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P2kevu

Migraine increases the proportion of sudden sensorineural hearing loss: A longitudinal follow-up study

The aim of the present study was to investigate the proportion of sudden sensorineural hearing loss (SSNHL) patients in a representative population cohort with migraine.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CT0gf9

Interaction Between Pitch and Timbre Perception in Normal-Hearing Listeners and Cochlear Implant Users

This study tested the interaction between pitch and sharpness (an aspect of timbre) perception related to the fundamental frequency (F0) and spectral slope of harmonic complex tones, respectively, in both NH listeners and CI users. In experiment 1, the F0 (and spectral slope) difference limens (DLs) were measured with a fixed spectral slope (and F0) and 20-dB amplitude roving. Then, the F0 and spectral slope were varied congruently or incongruently by the same multiple of individual DLs to assess the pitch and sharpness ranking sensitivity. Both NH and CI subjects had significantly higher pitch and sharpness ranking sensitivity with congruent than with incongruent F0 and spectral slope variations, and showed a similar symmetric interaction between pitch and timbre perception. In experiment...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JqJfuh

FDA May Require Products to List Sesame Allergen

Research suggests that more than 300,000 Americans have sesame allergy, according to Lisa Gable, CEO of the nonprofit group Food Allergy Research and Education. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Dest0W

Building Tolerance Helps Kids With Wheat Allergy

TUESDAY, Oct. 30, 2018 -- Giving trace amounts of wheat to children with wheat allergy shows promise in treating the allergy, according to new research. The researchers started with 46 wheat-allergic children, average age about 9 years, and gave... (Source: Drugs.com - Daily MedNews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JqJ9Tr

Interaction Between Pitch and Timbre Perception in Normal-Hearing Listeners and Cochlear Implant Users

This study tested the interaction between pitch and sharpness (an aspect of timbre) perception related to the fundamental frequency (F0) and spectral slope of harmonic complex tones, respectively, in both NH listeners and CI users. In experiment 1, the F0 (and spectral slope) difference limens (DLs) were measured with a fixed spectral slope (and F0) and 20-dB amplitude roving. Then, the F0 and spectral slope were varied congruently or incongruently by the same multiple of individual DLs to assess the pitch and sharpness ranking sensitivity. Both NH and CI subjects had significantly higher pitch and sharpness ranking sensitivity with congruent than with incongruent F0 and spectral slope variations, and showed a similar symmetric interaction between pitch and timbre perception. In experiment...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JqJfuh

FDA May Require Products to List Sesame Allergen

Research suggests that more than 300,000 Americans have sesame allergy, according to Lisa Gable, CEO of the nonprofit group Food Allergy Research and Education. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Dest0W

Building Tolerance Helps Kids With Wheat Allergy

TUESDAY, Oct. 30, 2018 -- Giving trace amounts of wheat to children with wheat allergy shows promise in treating the allergy, according to new research. The researchers started with 46 wheat-allergic children, average age about 9 years, and gave... (Source: Drugs.com - Daily MedNews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JqJ9Tr

Developmental Perceptual Impairments: Cases When Tone-Deafness and Prosopagnosia Co-occur

S ébastien Paquette, Hui C. Li, Sherryse L. Corrow, Stephanie S. Buss, Jason J. S. Barton, Gottfried Schlaug (Source: Frontiers in Human Neuroscience)

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Morning Break: 8,000 Gun Injuries in Youth; New Public Health Threat; Sesame Allergies Surge

(MedPage Today) -- Health news and commentary from around the Web gathered by the MedPage Today staff (Source: MedPage Today Allergy)

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Developmental Perceptual Impairments: Cases When Tone-Deafness and Prosopagnosia Co-occur

S ébastien Paquette, Hui C. Li, Sherryse L. Corrow, Stephanie S. Buss, Jason J. S. Barton, Gottfried Schlaug (Source: Frontiers in Human Neuroscience)

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Morning Break: 8,000 Gun Injuries in Youth; New Public Health Threat; Sesame Allergies Surge

(MedPage Today) -- Health news and commentary from around the Web gathered by the MedPage Today staff (Source: MedPage Today Allergy)

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Pretherapeutic assessment of hematologic and inflammatory markers in adenoid cystic carcinoma: neutrophil/lymphocyte ratio is associated with multiple recurrences

Adenoid cystic carcinoma (ACC) is a rare entity of salivary gland cancer. Inflammatory and hematologic markers and their prognostic and predictive value have been intensively studied in several cancer entities. The aim of this study is to investigate the role of such markers in patients with ACC.

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Pretherapeutic assessment of hematologic and inflammatory markers in adenoid cystic carcinoma: neutrophil/lymphocyte ratio is associated with multiple recurrences

Adenoid cystic carcinoma (ACC) is a rare entity of salivary gland cancer. Inflammatory and hematologic markers and their prognostic and predictive value have been intensively studied in several cancer entities. The aim of this study is to investigate the role of such markers in patients with ACC.

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Sentinel lymph node biopsy for early stage tongue cancer —a 14-year single-centre experience

This study was performed to report the usage of sentinel lymph node biopsy (SLNB) in clinical stage I or II tongue cancer patients with cN0 necks seen over a 14-year period. Data were collected prospectively, and a retrospective analysis was performed of 41 patients with early stage oral squamous cell carcinoma of the tongue and a cN0 neck. Sentinel lymph node (SLN)-positive patients underwent elective neck dissection, whereas SLN-negative patients were kept under careful observation. Seven of the 41 (17%) patients enrolled in the study were found to have occult metastases. (Source: International Journal of Oral and Maxillofacial Surgery)

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Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome

The facial malformations of Crouzon syndrome involve the entire cranio-orbito-zygomatic region. The detailed sequence of changes in orbit, zygoma, and maxilla over time, the mutual influence among these three anatomical structures, and their relationship with the cranial base were studied to determine the sequence and timing of deformity. Preoperative CT scans of 36 patients with Crouzon syndrome (mean age 10.84 ±14.70years; 14 male, 22 female) and CT scans of 54 control subjects (mean age 8.53±13.22years; 29 male, 25 female) were divided into five subgroups by age: 0–6 months, 6 months–2 years, 2–6 years, 6–18 years, and 18–62 years. (Source: International Journal of Oral and Maxillofacial Surgery)

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Regarding “Impact of crack cocaine use on the occurrence of oral lesions and micronuclei”

We read with interest the recent article by Antoniazzi and colleagues published in the International Journal of Oral& Maxillofacial Surgery entitled "Impact of crack cocaine use on the occurrence of oral lesions and micronuclei"1. In their study, the authors detected an increased number of fundamental lesions and micronuclei in the oral mucosa of crack cocaine users. However, there are certain questions related to data interpretation and acc uracy that must be addressed with regard to this study. (Source: International Journal of Oral and Maxillofacial Surgery)

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Sentinel lymph node biopsy for early stage tongue cancer —a 14-year single-centre experience

This study was performed to report the usage of sentinel lymph node biopsy (SLNB) in clinical stage I or II tongue cancer patients with cN0 necks seen over a 14-year period. Data were collected prospectively, and a retrospective analysis was performed of 41 patients with early stage oral squamous cell carcinoma of the tongue and a cN0 neck. Sentinel lymph node (SLN)-positive patients underwent elective neck dissection, whereas SLN-negative patients were kept under careful observation. Seven of the 41 (17%) patients enrolled in the study were found to have occult metastases. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CRzuUv

Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome

The facial malformations of Crouzon syndrome involve the entire cranio-orbito-zygomatic region. The detailed sequence of changes in orbit, zygoma, and maxilla over time, the mutual influence among these three anatomical structures, and their relationship with the cranial base were studied to determine the sequence and timing of deformity. Preoperative CT scans of 36 patients with Crouzon syndrome (mean age 10.84 ±14.70years; 14 male, 22 female) and CT scans of 54 control subjects (mean age 8.53±13.22years; 29 male, 25 female) were divided into five subgroups by age: 0–6 months, 6 months–2 years, 2–6 years, 6–18 years, and 18–62 years. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OYy165

Regarding “Impact of crack cocaine use on the occurrence of oral lesions and micronuclei”

We read with interest the recent article by Antoniazzi and colleagues published in the International Journal of Oral& Maxillofacial Surgery entitled "Impact of crack cocaine use on the occurrence of oral lesions and micronuclei"1. In their study, the authors detected an increased number of fundamental lesions and micronuclei in the oral mucosa of crack cocaine users. However, there are certain questions related to data interpretation and acc uracy that must be addressed with regard to this study. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CRzpQH

Epicutaneous immunotherapy for peanut allergy modifies IgG4 responses to major peanut allergens

Epicutaneous immunotherapy (EPIT) for peanut allergy is an investigational therapy currently in development. This study shows that EPIT induces IgG4 to the major peanut allergens, Ara h 1, h 2, h 3 and h 6.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SxdGTx

Interaction Between Pitch and Timbre Perception in Normal-Hearing Listeners and Cochlear Implant Users

Abstract

Despite their mutually exclusive definitions, pitch and timbre perception interact with each other in normal-hearing (NH) listeners. Cochlear implant (CI) users have worse than normal pitch and timbre perception. However, the pitch-timbre interaction with CIs is not well understood. This study tested the interaction between pitch and sharpness (an aspect of timbre) perception related to the fundamental frequency (F0) and spectral slope of harmonic complex tones, respectively, in both NH listeners and CI users. In experiment 1, the F0 (and spectral slope) difference limens (DLs) were measured with a fixed spectral slope (and F0) and 20-dB amplitude roving. Then, the F0 and spectral slope were varied congruently or incongruently by the same multiple of individual DLs to assess the pitch and sharpness ranking sensitivity. Both NH and CI subjects had significantly higher pitch and sharpness ranking sensitivity with congruent than with incongruent F0 and spectral slope variations, and showed a similar symmetric interaction between pitch and timbre perception. In experiment 2, CI users' melodic contour identification (MCI) was tested in three spectral slope (no, congruent, and incongruent spectral slope variations by the same multiple of individual DLs as the F0 variations) and two amplitude conditions (0- and 20-dB amplitude roving). When there was no amplitude roving, the MCI scores were significantly higher with congruent than with no, and in turn than with incongruent spectral slope variations. The 20-dB amplitude roving significantly reduced the overall MCI scores and the effect of spectral slope variations. These results reflected a confusion between higher (or lower) pitch and sharper (or duller) timbre and offered important implications for understanding and enhancing pitch and timbre perception with CIs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qhx0XY

Epicutaneous immunotherapy for peanut allergy modifies IgG4 responses to major peanut allergens

Epicutaneous immunotherapy (EPIT) for peanut allergy is an investigational therapy currently in development. This study shows that EPIT induces IgG4 to the major peanut allergens, Ara h 1, h 2, h 3 and h 6.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SxdGTx

Interaction Between Pitch and Timbre Perception in Normal-Hearing Listeners and Cochlear Implant Users

Abstract

Despite their mutually exclusive definitions, pitch and timbre perception interact with each other in normal-hearing (NH) listeners. Cochlear implant (CI) users have worse than normal pitch and timbre perception. However, the pitch-timbre interaction with CIs is not well understood. This study tested the interaction between pitch and sharpness (an aspect of timbre) perception related to the fundamental frequency (F0) and spectral slope of harmonic complex tones, respectively, in both NH listeners and CI users. In experiment 1, the F0 (and spectral slope) difference limens (DLs) were measured with a fixed spectral slope (and F0) and 20-dB amplitude roving. Then, the F0 and spectral slope were varied congruently or incongruently by the same multiple of individual DLs to assess the pitch and sharpness ranking sensitivity. Both NH and CI subjects had significantly higher pitch and sharpness ranking sensitivity with congruent than with incongruent F0 and spectral slope variations, and showed a similar symmetric interaction between pitch and timbre perception. In experiment 2, CI users' melodic contour identification (MCI) was tested in three spectral slope (no, congruent, and incongruent spectral slope variations by the same multiple of individual DLs as the F0 variations) and two amplitude conditions (0- and 20-dB amplitude roving). When there was no amplitude roving, the MCI scores were significantly higher with congruent than with no, and in turn than with incongruent spectral slope variations. The 20-dB amplitude roving significantly reduced the overall MCI scores and the effect of spectral slope variations. These results reflected a confusion between higher (or lower) pitch and sharper (or duller) timbre and offered important implications for understanding and enhancing pitch and timbre perception with CIs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qhx0XY

Brigham-born biotech startup testing food allergy drug

Startup ConsortiaTX finalized an agreement late last week to license a microbiome therapy from Brigham and Women's Hospital and Boston Children's Hospital. (Source: bizjournals.com Health Care:Physician Practices headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qmE5Xf

Medical News Today: What can cause red skin?

Skin redness is often harmless, but can sometimes be a symptom of another condition. Possible causes of red skin include burns, infections, and allergic reactions. Learn more here. (Source: Health News from Medical News Today)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6kW7j

Blood Eosinophils May Help Guide COPD Therapy Blood Eosinophils May Help Guide COPD Therapy

Blood eosinophil concentrations can help guide initial management of chronic obstructive pulmonary disease (COPD), new research suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qlfJNM

Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA ’ s new consideration of labeling for sesame allergies

Food allergies have touched the lives of most of us. Thousands of Americans experience life-threatening, food-related reactions each year, and an estimated 20 people die from them annually. In some cases, such reactions occur despite a careful reading of packaged food labels by conscientious consumers. To me, that ' s unacceptable. The FDA is committed to advancing our efforts to help ensure that Americans have access to the information they need about common allergens in packaged foods. (Source: Food and Drug Administration)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6kKVD

Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome

The facial malformations of Crouzon syndrome involve the entire cranio-orbito-zygomatic region. The detailed sequence of changes in orbit, zygoma, and maxilla over time, the mutual influence among these three anatomical structures, and their relationship with the cranial base were studied to determine the sequence and timing of deformity. Preoperative CT scans of 36 patients with Crouzon syndrome (mean age 10.84±14.70years; 14 male, 22 female) and CT scans of 54 control subjects (mean age 8.53±13.22years; 29 male, 25 female) were divided into five subgroups by age: 0–6 months, 6 months–2 years, 2–6 years, 6–18 years, and 18–62 years.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DdpyWj

Sentinel lymph node biopsy for early stage tongue cancer—a 14-year single-centre experience

This study was performed to report the usage of sentinel lymph node biopsy (SLNB) in clinical stage I or II tongue cancer patients with cN0 necks seen over a 14-year period. Data were collected prospectively, and a retrospective analysis was performed of 41 patients with early stage oral squamous cell carcinoma of the tongue and a cN0 neck. Sentinel lymph node (SLN)-positive patients underwent elective neck dissection, whereas SLN-negative patients were kept under careful observation. Seven of the 41 (17%) patients enrolled in the study were found to have occult metastases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JvrGcE

Regarding “Impact of crack cocaine use on the occurrence of oral lesions and micronuclei”

We read with interest the recent article by Antoniazzi and colleagues published in the International Journal of Oral & Maxillofacial Surgery entitled "Impact of crack cocaine use on the occurrence of oral lesions and micronuclei"1. In their study, the authors detected an increased number of fundamental lesions and micronuclei in the oral mucosa of crack cocaine users. However, there are certain questions related to data interpretation and accuracy that must be addressed with regard to this study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DeecBx

Morning Break: 8,000 Gun Injuries in Youth; New Public Health Threat; Sesame Allergies Surge

(MedPage Today) -- Health news and commentary from around the Web gathered by the MedPage Today staff (Source: MedPage Today Allergy)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q7KlxB

Medical News Today: What can cause red skin?

Skin redness is often harmless, but can sometimes be a symptom of another condition. Possible causes of red skin include burns, infections, and allergic reactions. Learn more here. (Source: Health News from Medical News Today)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6kW7j

Blood Eosinophils May Help Guide COPD Therapy Blood Eosinophils May Help Guide COPD Therapy

Blood eosinophil concentrations can help guide initial management of chronic obstructive pulmonary disease (COPD), new research suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qlfJNM

Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA ’ s new consideration of labeling for sesame allergies

Food allergies have touched the lives of most of us. Thousands of Americans experience life-threatening, food-related reactions each year, and an estimated 20 people die from them annually. In some cases, such reactions occur despite a careful reading of packaged food labels by conscientious consumers. To me, that ' s unacceptable. The FDA is committed to advancing our efforts to help ensure that Americans have access to the information they need about common allergens in packaged foods. (Source: Food and Drug Administration)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6kKVD

Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome

The facial malformations of Crouzon syndrome involve the entire cranio-orbito-zygomatic region. The detailed sequence of changes in orbit, zygoma, and maxilla over time, the mutual influence among these three anatomical structures, and their relationship with the cranial base were studied to determine the sequence and timing of deformity. Preoperative CT scans of 36 patients with Crouzon syndrome (mean age 10.84±14.70years; 14 male, 22 female) and CT scans of 54 control subjects (mean age 8.53±13.22years; 29 male, 25 female) were divided into five subgroups by age: 0–6 months, 6 months–2 years, 2–6 years, 6–18 years, and 18–62 years.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DdpyWj

Sentinel lymph node biopsy for early stage tongue cancer—a 14-year single-centre experience

This study was performed to report the usage of sentinel lymph node biopsy (SLNB) in clinical stage I or II tongue cancer patients with cN0 necks seen over a 14-year period. Data were collected prospectively, and a retrospective analysis was performed of 41 patients with early stage oral squamous cell carcinoma of the tongue and a cN0 neck. Sentinel lymph node (SLN)-positive patients underwent elective neck dissection, whereas SLN-negative patients were kept under careful observation. Seven of the 41 (17%) patients enrolled in the study were found to have occult metastases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JvrGcE

Regarding “Impact of crack cocaine use on the occurrence of oral lesions and micronuclei”

We read with interest the recent article by Antoniazzi and colleagues published in the International Journal of Oral & Maxillofacial Surgery entitled "Impact of crack cocaine use on the occurrence of oral lesions and micronuclei"1. In their study, the authors detected an increased number of fundamental lesions and micronuclei in the oral mucosa of crack cocaine users. However, there are certain questions related to data interpretation and accuracy that must be addressed with regard to this study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DeecBx

Blood Eosinophils May Help Guide COPD Therapy Blood Eosinophils May Help Guide COPD Therapy

Blood eosinophil concentrations can help guide initial management of chronic obstructive pulmonary disease (COPD), new research suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qlfJNM

Blood Eosinophils May Help Guide COPD Therapy Blood Eosinophils May Help Guide COPD Therapy

Blood eosinophil concentrations can help guide initial management of chronic obstructive pulmonary disease (COPD), new research suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qlfJNM

Allergen Exposure in Lymphopenic Fas-Deficient Mice Results in Persistent Eosinophilia Due to Defects in Resolution of Inflammation

Caroline M. Ferreira, Jesse W. Williams, Jiankun Tong, Crystal Rayon, Kelly M. Blaine, Anne I. Sperling (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CSOBwT

CD3+CD4+LAP+Foxp3-Regulatory Cells of the Colonic Lamina Propria Limit Disease Extension in Ulcerative Colitis

Alessia Butera, Massimo Sanchez, Annamaria Pronio, Antonello Amendola, Daniela De Nitto, Nazzareno Di Carlo, Roberto Lande, Loredana Frasca, Francesco Borrini, Roberta Pica, Monica Boirivant (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P1pe3m

Commentary: Arguing for Adaptive Clinical Trials in Sepsis

Miriam Kesselmeier, Andr é Scherag (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CUzbrY

Cross-Talk Between Iron and Glucose Metabolism in the Establishment of Disease Tolerance

Ana Rita Carlos, Sebastian Weis, Miguel P. Soares (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CR34JK

Precise Delineation and Transcriptional Characterization of Bovine Blood Dendritic-Cell and Monocyte Subsets

Stephanie C. Talker, Arnaud Baumann, G. Tuba Barut, Irene Keller, R émy Bruggmann, Artur Summerfield (Source: Frontiers in Immunology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OYgLy7

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

While TCR triggering is critical for adaptive immunity, how bioforces accompanying ligand binding transduce signals through the cell membrane is unknown. Brazin et  al. define dynamic structural movements within the TCRα transmembrane domain linked to fundamental TCR complex mechanobiology, including subunit topological rearrangements that foster dissociation of CD3 dimers and cell activation. (Source: Immunity)

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An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis

While anti-cytokine therapies show promising results in autoimmune diseases, its effects on cardiovascular disease development are not well understood. Fatkhullina and colleagues show that inactivation of IL-23-IL-22 signaling leads to deterioration of the intestinal barrier, expansion of pro-atherogenic bacteria, and production of metabolites promoting macrophage activation and atherosclerosis. (Source: Immunity)

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Rapid desensitization for brentuximab vedotin (Adceteris ®) allergy: a case report

Brentuximab vedotin (BV) is an antibody –drug conjugate formed by an anti-CD30 chimeric IgG1 conjugated with monomethyl-auristatin-E. BV targets the CD30+ cells, which characterize Hodgkin lymphoma as well as anap... (Source: Clinical and Molecular Allergy)

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21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I.

CONCLUSION: No overlapping autoimmune profile between TS and APS I was found. Autoimmunity against 21-OH among TS was more prevalent than previously identified suggesting an increased risk of adrenal failure in TS. However, whether adrenal impairment will develop remains unknown. This article is protected by copyright. All rights reserved. PMID: 30372540 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P0I4rh

Allergen Exposure in Lymphopenic Fas-Deficient Mice Results in Persistent Eosinophilia Due to Defects in Resolution of Inflammation

Caroline M. Ferreira, Jesse W. Williams, Jiankun Tong, Crystal Rayon, Kelly M. Blaine, Anne I. Sperling (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CSOBwT

CD3+CD4+LAP+Foxp3-Regulatory Cells of the Colonic Lamina Propria Limit Disease Extension in Ulcerative Colitis

Alessia Butera, Massimo Sanchez, Annamaria Pronio, Antonello Amendola, Daniela De Nitto, Nazzareno Di Carlo, Roberto Lande, Loredana Frasca, Francesco Borrini, Roberta Pica, Monica Boirivant (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P1pe3m

Cross-Talk Between Iron and Glucose Metabolism in the Establishment of Disease Tolerance

Ana Rita Carlos, Sebastian Weis, Miguel P. Soares (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CR34JK

T Cells in Adipose Tissue: Critical Players in Immunometabolism

Qun Wang, Huaizhu Wu (Source: Frontiers in Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CUzbbs

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

While TCR triggering is critical for adaptive immunity, how bioforces accompanying ligand binding transduce signals through the cell membrane is unknown. Brazin et  al. define dynamic structural movements within the TCRα transmembrane domain linked to fundamental TCR complex mechanobiology, including subunit topological rearrangements that foster dissociation of CD3 dimers and cell activation. (Source: Immunity)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OZZ7dj

Tissue-resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL-17.

This article is protected by copyright. All rights reserved. PMID: 30372518 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2COfKkN

21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I.

CONCLUSION: No overlapping autoimmune profile between TS and APS I was found. Autoimmunity against 21-OH among TS was more prevalent than previously identified suggesting an increased risk of adrenal failure in TS. However, whether adrenal impairment will develop remains unknown. This article is protected by copyright. All rights reserved. PMID: 30372540 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P0I4rh

Interaction Between Pitch and Timbre Perception in Normal-Hearing Listeners and Cochlear Implant Users

Abstract

Despite their mutually exclusive definitions, pitch and timbre perception interact with each other in normal-hearing (NH) listeners. Cochlear implant (CI) users have worse than normal pitch and timbre perception. However, the pitch-timbre interaction with CIs is not well understood. This study tested the interaction between pitch and sharpness (an aspect of timbre) perception related to the fundamental frequency (F0) and spectral slope of harmonic complex tones, respectively, in both NH listeners and CI users. In experiment 1, the F0 (and spectral slope) difference limens (DLs) were measured with a fixed spectral slope (and F0) and 20-dB amplitude roving. Then, the F0 and spectral slope were varied congruently or incongruently by the same multiple of individual DLs to assess the pitch and sharpness ranking sensitivity. Both NH and CI subjects had significantly higher pitch and sharpness ranking sensitivity with congruent than with incongruent F0 and spectral slope variations, and showed a similar symmetric interaction between pitch and timbre perception. In experiment 2, CI users' melodic contour identification (MCI) was tested in three spectral slope (no, congruent, and incongruent spectral slope variations by the same multiple of individual DLs as the F0 variations) and two amplitude conditions (0- and 20-dB amplitude roving). When there was no amplitude roving, the MCI scores were significantly higher with congruent than with no, and in turn than with incongruent spectral slope variations. The 20-dB amplitude roving significantly reduced the overall MCI scores and the effect of spectral slope variations. These results reflected a confusion between higher (or lower) pitch and sharper (or duller) timbre and offered important implications for understanding and enhancing pitch and timbre perception with CIs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qhx0XY

Interaction Between Pitch and Timbre Perception in Normal-Hearing Listeners and Cochlear Implant Users

Abstract

Despite their mutually exclusive definitions, pitch and timbre perception interact with each other in normal-hearing (NH) listeners. Cochlear implant (CI) users have worse than normal pitch and timbre perception. However, the pitch-timbre interaction with CIs is not well understood. This study tested the interaction between pitch and sharpness (an aspect of timbre) perception related to the fundamental frequency (F0) and spectral slope of harmonic complex tones, respectively, in both NH listeners and CI users. In experiment 1, the F0 (and spectral slope) difference limens (DLs) were measured with a fixed spectral slope (and F0) and 20-dB amplitude roving. Then, the F0 and spectral slope were varied congruently or incongruently by the same multiple of individual DLs to assess the pitch and sharpness ranking sensitivity. Both NH and CI subjects had significantly higher pitch and sharpness ranking sensitivity with congruent than with incongruent F0 and spectral slope variations, and showed a similar symmetric interaction between pitch and timbre perception. In experiment 2, CI users' melodic contour identification (MCI) was tested in three spectral slope (no, congruent, and incongruent spectral slope variations by the same multiple of individual DLs as the F0 variations) and two amplitude conditions (0- and 20-dB amplitude roving). When there was no amplitude roving, the MCI scores were significantly higher with congruent than with no, and in turn than with incongruent spectral slope variations. The 20-dB amplitude roving significantly reduced the overall MCI scores and the effect of spectral slope variations. These results reflected a confusion between higher (or lower) pitch and sharper (or duller) timbre and offered important implications for understanding and enhancing pitch and timbre perception with CIs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qhx0XY

Morning Break: 8,000 Gun Injuries in Youth; New Public Health Threat; Sesame Allergies Surge

(MedPage Today) -- Health news and commentary from around the Web gathered by the MedPage Today staff (Source: MedPage Today Allergy)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q7KlxB

Brigham-born biotech startup testing food allergy drug

Startup ConsortiaTX finalized an agreement late last week to license a microbiome therapy from Brigham and Women's Hospital and Boston Children's Hospital. (Source: bizjournals.com Health Care:Physician Practices headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qmE5Xf

Medical News Today: What can cause red skin?

Skin redness is often harmless, but can sometimes be a symptom of another condition. Possible causes of red skin include burns, infections, and allergic reactions. Learn more here. (Source: Health News from Medical News Today)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6kW7j

Blood Eosinophils May Help Guide COPD Therapy Blood Eosinophils May Help Guide COPD Therapy

Blood eosinophil concentrations can help guide initial management of chronic obstructive pulmonary disease (COPD), new research suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qlfJNM

Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA ’ s new consideration of labeling for sesame allergies

Food allergies have touched the lives of most of us. Thousands of Americans experience life-threatening, food-related reactions each year, and an estimated 20 people die from them annually. In some cases, such reactions occur despite a careful reading of packaged food labels by conscientious consumers. To me, that ' s unacceptable. The FDA is committed to advancing our efforts to help ensure that Americans have access to the information they need about common allergens in packaged foods. (Source: Food and Drug Administration)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6kKVD

Morning Break: 8,000 Gun Injuries in Youth; New Public Health Threat; Sesame Allergies Surge

(MedPage Today) -- Health news and commentary from around the Web gathered by the MedPage Today staff (Source: MedPage Today Allergy)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q7KlxB

Brigham-born biotech startup testing food allergy drug

Startup ConsortiaTX finalized an agreement late last week to license a microbiome therapy from Brigham and Women's Hospital and Boston Children's Hospital. (Source: bizjournals.com Health Care:Physician Practices headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qmE5Xf

Medical News Today: What can cause red skin?

Skin redness is often harmless, but can sometimes be a symptom of another condition. Possible causes of red skin include burns, infections, and allergic reactions. Learn more here. (Source: Health News from Medical News Today)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6kW7j

Blood Eosinophils May Help Guide COPD Therapy Blood Eosinophils May Help Guide COPD Therapy

Blood eosinophil concentrations can help guide initial management of chronic obstructive pulmonary disease (COPD), new research suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qlfJNM

Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA ’ s new consideration of labeling for sesame allergies

Food allergies have touched the lives of most of us. Thousands of Americans experience life-threatening, food-related reactions each year, and an estimated 20 people die from them annually. In some cases, such reactions occur despite a careful reading of packaged food labels by conscientious consumers. To me, that ' s unacceptable. The FDA is committed to advancing our efforts to help ensure that Americans have access to the information they need about common allergens in packaged foods. (Source: Food and Drug Administration)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6kKVD

Neural mechanisms of emotion regulation and their role in endocrine and immune functioning: A review with implications for treatment of affective disorders

Publication date: Available online 29 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Richard B. Lopez, Bryan T. Denny, Christopher P. FagundesAbstractIn the past century, medical progress has helped increase life expectancy and improve health outcomes more generally. Despite this progress, psychiatric disorders—especially affective disorders including depressive and anxiety disorders—are quite common and have been linked to dysfunction in endocrine and immune systems. In this review, we discuss neurobiological correlates of emotion regulation strategies and their effects on mental and physical health. Some of these correlates, namely sub-regions of prefrontal cortex, also play a key regulatory role in autonomic, endocrine, and immunological processes. Given this fun...

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Disruptions in the reproductive system of female rats after prenatal lipopolysaccharide-induced immunological stress: role of sex steroids.

This study was aimed to test the hypothesis that prenatal immunological stress induced by bacterial endotoxin, lipopolysaccharide (LPS), has impact on structure and function of the reproductive system in female offspring. Adult female Wistar rats were divided into two groups, a control group (n = 5) and a LPS group (n = 12). Rats were injected with LPS 50 μg/kg body or 0.9% saline intraperitoneally on the 12th day of pregnancy. After birth the female pups (n = 20 in each group) were divided into four groups: (group 1) 0.9% saline prenatally, sesame oil (vehicle) postnatally; (group 2) LPS prenatally, sesame oil postnatally; (group 3) LPS prenatally, fulvestrant postnatally; (group 4) LPS prenatally, flutamide postnatally. Pups were injected subcutaneously into the neck with ...

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Neural mechanisms of emotion regulation and their role in endocrine and immune functioning: A review with implications for treatment of affective disorders

Publication date: Available online 29 October 2018Source: Neuroscience & Biobehavioral ReviewsAuthor(s): Richard B. Lopez, Bryan T. Denny, Christopher P. FagundesAbstractIn the past century, medical progress has helped increase life expectancy and improve health outcomes more generally. Despite this progress, psychiatric disorders—especially affective disorders including depressive and anxiety disorders—are quite common and have been linked to dysfunction in endocrine and immune systems. In this review, we discuss neurobiological correlates of emotion regulation strategies and their effects on mental and physical health. Some of these correlates, namely sub-regions of prefrontal cortex, also play a key regulatory role in autonomic, endocrine, and immunological processes. Given this fun...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q1Pxmu

Disruptions in the reproductive system of female rats after prenatal lipopolysaccharide-induced immunological stress: role of sex steroids.

This study was aimed to test the hypothesis that prenatal immunological stress induced by bacterial endotoxin, lipopolysaccharide (LPS), has impact on structure and function of the reproductive system in female offspring. Adult female Wistar rats were divided into two groups, a control group (n = 5) and a LPS group (n = 12). Rats were injected with LPS 50 μg/kg body or 0.9% saline intraperitoneally on the 12th day of pregnancy. After birth the female pups (n = 20 in each group) were divided into four groups: (group 1) 0.9% saline prenatally, sesame oil (vehicle) postnatally; (group 2) LPS prenatally, sesame oil postnatally; (group 3) LPS prenatally, fulvestrant postnatally; (group 4) LPS prenatally, flutamide postnatally. Pups were injected subcutaneously into the neck with ...

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That's a lot of scratch: The $48,329 Allergy Test

An English professor in California got an allergy test. Then came the bill. (Source: ABC News: Health)

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Calcitonin measurement in fine-needle aspirate washout fluid by electrochemiluminescence immunoassay for thyroid tumors

For the differential diagnosis of medullary thyroid carcinoma (MTC) on thyroid nodules, ultrasound-guided fine-needle aspiration cytology is a useful and safe procedure, but its diagnostic accuracy is not high...

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That's a lot of scratch: The $48,329 Allergy Test

An English professor in California got an allergy test. Then came the bill. (Source: ABC News: Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OZPLyd

Calcitonin measurement in fine-needle aspirate washout fluid by electrochemiluminescence immunoassay for thyroid tumors

For the differential diagnosis of medullary thyroid carcinoma (MTC) on thyroid nodules, ultrasound-guided fine-needle aspiration cytology is a useful and safe procedure, but its diagnostic accuracy is not high...

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Interleukin-4 (IL-4) may regulate alternative activation of macrophage-like cells in chickens: a sequential study using novel and specific neutralizing monoclonal antibodies against chicken IL-4

Publication date: Available online 29 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Atul A. Chaudhari, Woo H. Kim, Hyun S. LillehojAbstractIn mammals, alternatively activated macrophages (AAMs) are well-recognized and are produced by stimulation with Th2 cytokines such as interleukin 4 (IL-4) and IL-13. On their mammalian counterparts, AAMs in chickens has neither been reported nor the functionality of chicken IL-4 (chIL-4) has been studied till date. Therefore, present study developed mouse monoclonal antibodies (mAbs) against chIL-4 and used these antibodies to investigate whether chIL-4 induces activation of HD11 chicken macrophage cell line. Upon characterization of mAbs using western blot, immunocytochemistry (ICC), flow cytometry and capture ELISA, activatio...

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Comparative proteomics identified immune response proteins involved in response to vaccination with heat-inactivated Mycobacterium bovis and mycobacterial challenge in cattle

In conclusion, this study provides a first indication of the role of several immune system pathways in response to the heat-inactivated M. bovis vaccine and mycobacterial challenge. (Source: Veterinary Immunology and Immunopathology)

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Oclacitinib depletes canine CD4+ and CD8+ T cells in vitro

Publication date: Available online 29 October 2018Source: Research in Veterinary ScienceAuthor(s): Agnieszka Jasiecka-Mikołajczyk, Jerzy J. Jaroszewski, Tomasz MaślankaAbstractOclacitinib (OCL) is a novel immunosuppressive agent approved for dogs that controls itch and inflammation in allergic disease via the inhibition of the JAK/STAT pathway. This paper investigates the in vitro effect of OCL, a novel Janus kinase inhibitor, on selected canine regulatory (Treg) and effector (Teff) CD4+ and CD8+ T cells. Exposure of peripheral blood lymphocytes to OCL did not affect the transcription factor Foxp3 (Forkhead Box P3 protein) expression in CD25+CD4+ and CD25+CD8+ T cells. Moreover, OCL did not influence constitutive CD25 expression on these cells although it reduced the activation-induced C...

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Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells.

Authors: Bin BH, Seo J, Kim ST Abstract Zinc is an important trace metal in immune systems, and zinc transporters are involved in many immune responses. Recent advances have revealed the structural and biochemical bases for zinc transport across the cell membrane, with clinical implications for the regulation of zinc homeostasis in immune cells like dendritic cells, T cells, B cells, and mast cells. In this review, we discuss the function, structure, and transport aspects of two major mammalian zinc transporter types, importers and exporters. First, Zrt-/Irt-like proteins (ZIPs) mediate the zinc influx from the extracellular or luminal side into the cytoplasm. There are 14 ZIP family members in humans. They form a homo- or heterodimer with 8 transmembrane domains and extra-/intrace...

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Ultra-sensitive method based on time-resolved fluorescence immunoassay for detection of sulfamethazine in raw milk

Volume 29, Issue 1, December 2018, Page 1137-1149 . (Source: Food and Agricultural Immunology)

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Development of an immunochromatographic test strip for the detection of procaine in milk

Volume 29, Issue 1, December 2018, Page 1150-1161 . (Source: Food and Agricultural Immunology)

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Rapid detection of penbutolol in pig urine using an immunochromatographic test strip

Volume 29, Issue 1, December 2018, Page 1126-1136 . (Source: Food and Agricultural Immunology)

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Interleukin-4 (IL-4) may regulate alternative activation of macrophage-like cells in chickens: a sequential study using novel and specific neutralizing monoclonal antibodies against chicken IL-4

Publication date: Available online 29 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Atul A. Chaudhari, Woo H. Kim, Hyun S. LillehojAbstractIn mammals, alternatively activated macrophages (AAMs) are well-recognized and are produced by stimulation with Th2 cytokines such as interleukin 4 (IL-4) and IL-13. On their mammalian counterparts, AAMs in chickens has neither been reported nor the functionality of chicken IL-4 (chIL-4) has been studied till date. Therefore, present study developed mouse monoclonal antibodies (mAbs) against chIL-4 and used these antibodies to investigate whether chIL-4 induces activation of HD11 chicken macrophage cell line. Upon characterization of mAbs using western blot, immunocytochemistry (ICC), flow cytometry and capture ELISA, activatio...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ETu8Lj

Comparative proteomics identified immune response proteins involved in response to vaccination with heat-inactivated Mycobacterium bovis and mycobacterial challenge in cattle

In conclusion, this study provides a first indication of the role of several immune system pathways in response to the heat-inactivated M. bovis vaccine and mycobacterial challenge. (Source: Veterinary Immunology and Immunopathology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AACLGq

Oclacitinib depletes canine CD4+ and CD8+ T cells in vitro

Publication date: Available online 29 October 2018Source: Research in Veterinary ScienceAuthor(s): Agnieszka Jasiecka-Mikołajczyk, Jerzy J. Jaroszewski, Tomasz MaślankaAbstractOclacitinib (OCL) is a novel immunosuppressive agent approved for dogs that controls itch and inflammation in allergic disease via the inhibition of the JAK/STAT pathway. This paper investigates the in vitro effect of OCL, a novel Janus kinase inhibitor, on selected canine regulatory (Treg) and effector (Teff) CD4+ and CD8+ T cells. Exposure of peripheral blood lymphocytes to OCL did not affect the transcription factor Foxp3 (Forkhead Box P3 protein) expression in CD25+CD4+ and CD25+CD8+ T cells. Moreover, OCL did not influence constitutive CD25 expression on these cells although it reduced the activation-induced C...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EQjDs0

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells.

Authors: Bin BH, Seo J, Kim ST Abstract Zinc is an important trace metal in immune systems, and zinc transporters are involved in many immune responses. Recent advances have revealed the structural and biochemical bases for zinc transport across the cell membrane, with clinical implications for the regulation of zinc homeostasis in immune cells like dendritic cells, T cells, B cells, and mast cells. In this review, we discuss the function, structure, and transport aspects of two major mammalian zinc transporter types, importers and exporters. First, Zrt-/Irt-like proteins (ZIPs) mediate the zinc influx from the extracellular or luminal side into the cytoplasm. There are 14 ZIP family members in humans. They form a homo- or heterodimer with 8 transmembrane domains and extra-/intrace...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AACC5Q

Development of an immunochromatographic test strip for the detection of procaine in milk

Volume 29, Issue 1, December 2018, Page 1150-1161 . (Source: Food and Agricultural Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EStduA

Ultra-sensitive method based on time-resolved fluorescence immunoassay for detection of sulfamethazine in raw milk

Volume 29, Issue 1, December 2018, Page 1137-1149 . (Source: Food and Agricultural Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ABL3xF

Rapid detection of penbutolol in pig urine using an immunochromatographic test strip

Volume 29, Issue 1, December 2018, Page 1126-1136 . (Source: Food and Agricultural Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ETFleE

That's a lot of scratch: The $48,329 Allergy Test

An English professor in California got an allergy test. Then came the bill. (Source: ABC News: Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OZPLyd

That's a lot of scratch: The $48,329 Allergy Test

An English professor in California got an allergy test. Then came the bill. (Source: ABC News: Health)

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New Concerns About Sesame Allergies

(CNN) — Sesame could become the newest allergen added to the list of foods required to be named on labels, US Food and Drug Administration Commissioner Dr. Scott Gottlieb announced Monday. Eight major food allergens must currently be declared on US labeling using their common names: milk, eggs, fish, shellfish, tree nuts, peanuts, wheat and soybeans. These foods accounted for over 90% of documented serious food allergies in the country when the Food Allergen Labeling and Consumer Protection Act, which required the clear labeling of ingredients, was passed in 2004. The FDA cites the undeclared presence of allergens as one of the leading reasons for food recalls and a public health issue. "Unfortunately, we're beginning to see evidence that sesame allergies may be a growing...

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Mount Sinai researchers find wheat oral immunotherapy to be therapeutic for allergic patients

(The Mount Sinai Hospital / Mount Sinai School of Medicine) In a major step towards understanding the safety and efficacy of wheat oral immunotherapy, Mount Sinai researchers report promising results from the first multicenter, rigorous clinical trial in the Journal of Allergy and Clinical Immunology. (Source: EurekAlert! - Biology)

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New Concerns About Sesame Allergies

(CNN) — Sesame could become the newest allergen added to the list of foods required to be named on labels, US Food and Drug Administration Commissioner Dr. Scott Gottlieb announced Monday. Eight major food allergens must currently be declared on US labeling using their common names: milk, eggs, fish, shellfish, tree nuts, peanuts, wheat and soybeans. These foods accounted for over 90% of documented serious food allergies in the country when the Food Allergen Labeling and Consumer Protection Act, which required the clear labeling of ingredients, was passed in 2004. The FDA cites the undeclared presence of allergens as one of the leading reasons for food recalls and a public health issue. "Unfortunately, we're beginning to see evidence that sesame allergies may be a growing...

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Mount Sinai researchers find wheat oral immunotherapy to be therapeutic for allergic patients

(The Mount Sinai Hospital / Mount Sinai School of Medicine) In a major step towards understanding the safety and efficacy of wheat oral immunotherapy, Mount Sinai researchers report promising results from the first multicenter, rigorous clinical trial in the Journal of Allergy and Clinical Immunology. (Source: EurekAlert! - Biology)

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Preoperative anxiety and associated factors among adult surgical patients in Debre Markos and Felege Hiwot referral hospitals, Northwest Ethiopia

Abstract

Background

Anxiety during the preoperative period is the most common problem with a number of postoperative complications such as an increase in postoperative pain, delay of healing and prolong the hospital stay. Further, patients with a high level of preoperative anxiety require higher doses of anesthetic agents and recover poorly. Despite its serious health complications, its magnitude and associated factors have been poorly explored in Ethiopia particularly in the selected study areas.

Objective

To assess preoperative anxiety and associated factors among adult surgical patients in Debre Markos and Felege Hiwot Referral Hospitals, Northwest Ethiopia.

Method

An institution based cross-sectional study was conducted on 353 patients scheduled for surgery using a systematic random sampling technique. The data were collected using the state version of the state-trait anxiety inventory scale. All collected data were entered into Epi-Data version 3.1 and analysis was done by using SPSS version 20 software. Binary logistic regression was performed to assess the effect of independent variables on the dependent variable. A p-value < 0.05 was considered as statistically significant.

Results

Overall, 61% (95%CI (55.5–65.7)) patients had significant high level of preoperative anxiety. The most common reported factor responsible for preoperative anxiety was fear of complications 187(52.4%). There was a statistically significant high level of pre-operative anxiety among female patients [AOR 2.19 (95%CI (1.29–3.71))] and patients who lack preoperative information [AOR 2.03(95%CI (1.22–3.39))].

Conclusion

The prevalence of preoperative anxiety was high. The level of preoperative anxiety significantly associated with sex, preoperative information provision, and previous surgical experience. Preoperative psychosocial assessment should be incorporated into a routine nursing practice and every patient should be provided with preoperative information before surgery.

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Programmed intermittent epidural bolus versus continuous epidural infusion for postoperative analgesia after major abdominal and gynecological cancer surgery: a randomized, triple-blinded clinical trial

Abstract

Background

Continuous epidural infusion (CEI) is the standard application setting for epidural infusion. A new mode, the programmed intermittent epidural bolus (PIEB) technique, showed reduced local anesthetic (LA) consumption and improved analgesia in obstetric analgesia. Goal of this trial was to evaluate the effects of PIEB versus CEI [combined with patient-controlled bolus (PCEA)] on LA consumption and pain scorings in major abdominal cancer surgery.

Methods

Following ethical approval, patients scheduled for major abdominal cancer surgery under general anesthesia in combination with epidural analgesia were randomized to receive either a PIEB mode of 6 mL/h or a CEI mode set at 6 mL/h of ropivacaine 0.2%, both combined with a PCEA mode set at a 4 mL bolus. LA consumptions and pain scorings were documented until the second postoperative evening.

Results

Eighty-four datasets were analyzed (CEI: n = 40, PIEB: n = 44). Regarding the primary endpoint, cumulative LA PCEA bolus volumes until day 2 differed significantly between the groups [PIEB 10 mL (2–28 mL) versus CEI, 28 mL (12–64 mL), median (25th–75th percentiles), p = 0.002]. Overall, LA consumption volumes were significantly lower in the PIEB group versus in the CEI group [PIEB: 329 mL (291–341 mL) vs. CEI: 350 mL (327–381 mL), p = 0.003]. Pain scores were comparable at each time point.

Conclusions

This trial demonstrates reduced needs for PCEA bolus in the PIEB group. There were no clinically relevant benefits regarding morphine consumption, pain scorings, or other secondary outcome parameters.

Trial registration

This study has been registered retrospectively in the ClinicalTrials.gov registry (NCT03378804), date of registration: December, 20th 2017.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zjF9PM

Preoperative anxiety and associated factors among adult surgical patients in Debre Markos and Felege Hiwot referral hospitals, Northwest Ethiopia

Abstract

Background

Anxiety during the preoperative period is the most common problem with a number of postoperative complications such as an increase in postoperative pain, delay of healing and prolong the hospital stay. Further, patients with a high level of preoperative anxiety require higher doses of anesthetic agents and recover poorly. Despite its serious health complications, its magnitude and associated factors have been poorly explored in Ethiopia particularly in the selected study areas.

Objective

To assess preoperative anxiety and associated factors among adult surgical patients in Debre Markos and Felege Hiwot Referral Hospitals, Northwest Ethiopia.

Method

An institution based cross-sectional study was conducted on 353 patients scheduled for surgery using a systematic random sampling technique. The data were collected using the state version of the state-trait anxiety inventory scale. All collected data were entered into Epi-Data version 3.1 and analysis was done by using SPSS version 20 software. Binary logistic regression was performed to assess the effect of independent variables on the dependent variable. A p-value < 0.05 was considered as statistically significant.

Results

Overall, 61% (95%CI (55.5–65.7)) patients had significant high level of preoperative anxiety. The most common reported factor responsible for preoperative anxiety was fear of complications 187(52.4%). There was a statistically significant high level of pre-operative anxiety among female patients [AOR 2.19 (95%CI (1.29–3.71))] and patients who lack preoperative information [AOR 2.03(95%CI (1.22–3.39))].

Conclusion

The prevalence of preoperative anxiety was high. The level of preoperative anxiety significantly associated with sex, preoperative information provision, and previous surgical experience. Preoperative psychosocial assessment should be incorporated into a routine nursing practice and every patient should be provided with preoperative information before surgery.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PuElBJ

Programmed intermittent epidural bolus versus continuous epidural infusion for postoperative analgesia after major abdominal and gynecological cancer surgery: a randomized, triple-blinded clinical trial

Abstract

Background

Continuous epidural infusion (CEI) is the standard application setting for epidural infusion. A new mode, the programmed intermittent epidural bolus (PIEB) technique, showed reduced local anesthetic (LA) consumption and improved analgesia in obstetric analgesia. Goal of this trial was to evaluate the effects of PIEB versus CEI [combined with patient-controlled bolus (PCEA)] on LA consumption and pain scorings in major abdominal cancer surgery.

Methods

Following ethical approval, patients scheduled for major abdominal cancer surgery under general anesthesia in combination with epidural analgesia were randomized to receive either a PIEB mode of 6 mL/h or a CEI mode set at 6 mL/h of ropivacaine 0.2%, both combined with a PCEA mode set at a 4 mL bolus. LA consumptions and pain scorings were documented until the second postoperative evening.

Results

Eighty-four datasets were analyzed (CEI: n = 40, PIEB: n = 44). Regarding the primary endpoint, cumulative LA PCEA bolus volumes until day 2 differed significantly between the groups [PIEB 10 mL (2–28 mL) versus CEI, 28 mL (12–64 mL), median (25th–75th percentiles), p = 0.002]. Overall, LA consumption volumes were significantly lower in the PIEB group versus in the CEI group [PIEB: 329 mL (291–341 mL) vs. CEI: 350 mL (327–381 mL), p = 0.003]. Pain scores were comparable at each time point.

Conclusions

This trial demonstrates reduced needs for PCEA bolus in the PIEB group. There were no clinically relevant benefits regarding morphine consumption, pain scorings, or other secondary outcome parameters.

Trial registration

This study has been registered retrospectively in the ClinicalTrials.gov registry (NCT03378804), date of registration: December, 20th 2017.

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c-Jun regulates the promoter of small subunit hemocyanin gene of Litopenaeus vannamei

Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Peikui Yang, Defu Yao, Jude Juventus Aweya, Fan Wang, Pei Ning, Shengkang Li, Hongyu Ma, Yueling ZhangAbstractHemocyanin (HMC) is a respiratory glycoprotein, which also plays multifunctional non-specific innate immune defense functions in shrimp. However, the transcriptional regulatory mechanisms of the hemocyanin gene expression have not been reported. In the present study, we cloned a 4324 bp fragment of small subunit hemocyanin (HMCs) gene of Litopenaeus vannamei including the 5′-flanking region, from upstream 2475 bp to downstream 1849 bp (exon 1-intron 1-exon 2) by genome walking method. Four deletion constructs were then generated and their promoter activity assessed using the luciferase reporter...

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Molecular characterization and expression analysis of Asian swamp eel (Monopterus albus) CXC chemokine receptor (CXCR) 1a, CXCR1b, CXCR2, CXCR3a, CXCR3b, and CXCR4 after bacteria and poly I:C challenge

In this study, six Asian swamp eel (Monopterus albus) CXCRs (MaCXCR1–4) were identified and their molecular characterization and expression patterns were analyzed. The open reading frames (ORFs) of MaCXCR1a, MaCXCR1b, MaCXCR2, MaCXCR3a, MaCXCR3b, and MaCXCR4 were 1074 bp (base pairs), 1080 bp, 1125 bp, 1146 bp, 1083 bp, and 1140 bp, and encoded proteins of 357 aa (amino acids), 359 aa, 374 aa, 381 aa, 360 aa, and 379 aa, respectively. All these CXCRs have seven conserved transmembrane domains and four cysteines (with the exception of MaCXCR3b). Multiple sequence alignment revealed that the MaCXCRs possess a typical G-protein receptor family 1 signature and a DRY motif. There are also one to four potential N-glycosylation sites in the extracellular regions of the MaCXCRs, mainly distribut...

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Integrative transcriptome analysis and discovery of genes involving in immune response of hypoxia/thermal challenges in the small abalone Haliotis diversicolor

In this study, the transcriptome profiles by RNA-seq of hemocytes from the small abalone Haliotis diversicolor after exposure to hypoxia, thermal stress, and hypoxia plus thermal stress were established. A total of 103,703,074 clean reads were obtained and 99,774 unigenes were assembled. Of the 99,774 unigenes, 47,154 and 20,455 had homologous sequences in the Nr and Swiss-Prot protein databases, while 16,944 and 10,840 unigenes could be classified by COG or KEGG databases, respectively. RNAseq analysis revealed that the differentially expressed genes (DEGs) after challenges of hypoxia, thermal stress, or hypoxia plus thermal stress were 24,189, 29,165 and 23,665, among which more than 3000 genes involved in at least 230 pathways, including several classical immune-related pathways. The ge...

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Characterization, expression profiling and functional characterization of cathepsin Z (CTSZ) in turbot (Scophthalmus maximus L.)

In this study, we reported the identification of SmCTSZ, a CTSZ homolog from turbot (Scophthalmus maximus L.). SmCTSZ was 317 residues in length and contains a Pept-C1 domain. In multiple species comparison, SmCTSZ shared 65–93% overall sequence identities with the CTSZ counterparts from human, rat, and several fish species. In the phylogenetic analysis, SmCTSZ showed the closest relationship to Cynoglossus semilaevis. The syntenic analysis revealed the similar neighboring genes of CTSZ across all the selected species, which suggested the synteny encompassing CTSZ region during vertebrate evolution. Subsequently, SmCTSZ was constitutively expressed in various tissues, with the lowest and highest levels in brain and intestine respectively. In addition, SmCTSZ was significantly up-regulate...

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Chronic exposure to the ionic liquid [C8mim]Br induces inflammation in silver carp spleen: Involvement of oxidative stress-mediated p38MAPK/NF-κB signalling and microRNAs

Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Junguo Ma, Xi Chen, Guangyuan Xin, Xiaoyu LiAbstractThe present study aimed to determine the chronic toxicity of 1-methyl-3-octylimidazolium bromide ([C8mim]Br) on the silver carp to further reveal the toxicological mechanisms of ionic liquids. Chronic exposure of silver carp to [C8mim]Br at concentrations of 1.095 and 4.380 mg/L for 60 d was conducted under laboratory conditions. The results revealed that chronic exposure to [C8mim]Br inhibited the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduced glutathione (GSH) levels while markedly increasing malondialdehyde (MDA) and protein carbonyl (PC) levels in fish spleen, indicating that [C8mim]Br treatm...

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WSSV–host interaction: Host response and immune evasion

Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Chaozheng Li, Shaoping Weng, Jianguo HeAbstractAs invertebrates, shrimps rely on multiple innate defense reactions, including humoral immunity and cellular immunity to recognize and eliminate various invaders, such as viruses. White spot syndrome virus (WSSV) causes the most prevalent and devastating viral disease in penaeid shrimps, which are the most widely cultured species in the coastal waters worldwide. In the last couple of decades, studies about WSSV implicate a dual role of the immune system in protecting shrimps against the infection; these studies also explore on the pathogenesis of WSSV infection. Herein, we review our current knowledge of the innate immune responses of shrimps to WSSV, as wel...

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c-Jun regulates the promoter of small subunit hemocyanin gene of Litopenaeus vannamei

Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Peikui Yang, Defu Yao, Jude Juventus Aweya, Fan Wang, Pei Ning, Shengkang Li, Hongyu Ma, Yueling ZhangAbstractHemocyanin (HMC) is a respiratory glycoprotein, which also plays multifunctional non-specific innate immune defense functions in shrimp. However, the transcriptional regulatory mechanisms of the hemocyanin gene expression have not been reported. In the present study, we cloned a 4324 bp fragment of small subunit hemocyanin (HMCs) gene of Litopenaeus vannamei including the 5′-flanking region, from upstream 2475 bp to downstream 1849 bp (exon 1-intron 1-exon 2) by genome walking method. Four deletion constructs were then generated and their promoter activity assessed using the luciferase reporter...

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Molecular characterization and expression analysis of Asian swamp eel (Monopterus albus) CXC chemokine receptor (CXCR) 1a, CXCR1b, CXCR2, CXCR3a, CXCR3b, and CXCR4 after bacteria and poly I:C challenge

In this study, six Asian swamp eel (Monopterus albus) CXCRs (MaCXCR1–4) were identified and their molecular characterization and expression patterns were analyzed. The open reading frames (ORFs) of MaCXCR1a, MaCXCR1b, MaCXCR2, MaCXCR3a, MaCXCR3b, and MaCXCR4 were 1074 bp (base pairs), 1080 bp, 1125 bp, 1146 bp, 1083 bp, and 1140 bp, and encoded proteins of 357 aa (amino acids), 359 aa, 374 aa, 381 aa, 360 aa, and 379 aa, respectively. All these CXCRs have seven conserved transmembrane domains and four cysteines (with the exception of MaCXCR3b). Multiple sequence alignment revealed that the MaCXCRs possess a typical G-protein receptor family 1 signature and a DRY motif. There are also one to four potential N-glycosylation sites in the extracellular regions of the MaCXCRs, mainly distribut...

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Integrative transcriptome analysis and discovery of genes involving in immune response of hypoxia/thermal challenges in the small abalone Haliotis diversicolor

In this study, the transcriptome profiles by RNA-seq of hemocytes from the small abalone Haliotis diversicolor after exposure to hypoxia, thermal stress, and hypoxia plus thermal stress were established. A total of 103,703,074 clean reads were obtained and 99,774 unigenes were assembled. Of the 99,774 unigenes, 47,154 and 20,455 had homologous sequences in the Nr and Swiss-Prot protein databases, while 16,944 and 10,840 unigenes could be classified by COG or KEGG databases, respectively. RNAseq analysis revealed that the differentially expressed genes (DEGs) after challenges of hypoxia, thermal stress, or hypoxia plus thermal stress were 24,189, 29,165 and 23,665, among which more than 3000 genes involved in at least 230 pathways, including several classical immune-related pathways. The ge...

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Characterization, expression profiling and functional characterization of cathepsin Z (CTSZ) in turbot (Scophthalmus maximus L.)

In this study, we reported the identification of SmCTSZ, a CTSZ homolog from turbot (Scophthalmus maximus L.). SmCTSZ was 317 residues in length and contains a Pept-C1 domain. In multiple species comparison, SmCTSZ shared 65–93% overall sequence identities with the CTSZ counterparts from human, rat, and several fish species. In the phylogenetic analysis, SmCTSZ showed the closest relationship to Cynoglossus semilaevis. The syntenic analysis revealed the similar neighboring genes of CTSZ across all the selected species, which suggested the synteny encompassing CTSZ region during vertebrate evolution. Subsequently, SmCTSZ was constitutively expressed in various tissues, with the lowest and highest levels in brain and intestine respectively. In addition, SmCTSZ was significantly up-regulate...

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Chronic exposure to the ionic liquid [C8mim]Br induces inflammation in silver carp spleen: Involvement of oxidative stress-mediated p38MAPK/NF-κB signalling and microRNAs

Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Junguo Ma, Xi Chen, Guangyuan Xin, Xiaoyu LiAbstractThe present study aimed to determine the chronic toxicity of 1-methyl-3-octylimidazolium bromide ([C8mim]Br) on the silver carp to further reveal the toxicological mechanisms of ionic liquids. Chronic exposure of silver carp to [C8mim]Br at concentrations of 1.095 and 4.380 mg/L for 60 d was conducted under laboratory conditions. The results revealed that chronic exposure to [C8mim]Br inhibited the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduced glutathione (GSH) levels while markedly increasing malondialdehyde (MDA) and protein carbonyl (PC) levels in fish spleen, indicating that [C8mim]Br treatm...

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WSSV–host interaction: Host response and immune evasion

Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Chaozheng Li, Shaoping Weng, Jianguo HeAbstractAs invertebrates, shrimps rely on multiple innate defense reactions, including humoral immunity and cellular immunity to recognize and eliminate various invaders, such as viruses. White spot syndrome virus (WSSV) causes the most prevalent and devastating viral disease in penaeid shrimps, which are the most widely cultured species in the coastal waters worldwide. In the last couple of decades, studies about WSSV implicate a dual role of the immune system in protecting shrimps against the infection; these studies also explore on the pathogenesis of WSSV infection. Herein, we review our current knowledge of the innate immune responses of shrimps to WSSV, as wel...

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New Concerns About Sesame Allergies

(CNN) — Sesame could become the newest allergen added to the list of foods required to be named on labels, US Food and Drug Administration Commissioner Dr. Scott Gottlieb announced Monday. Eight major food allergens must currently be declared on US labeling using their common names: milk, eggs, fish, shellfish, tree nuts, peanuts, wheat and soybeans. These foods accounted for over 90% of documented serious food allergies in the country when the Food Allergen Labeling and Consumer Protection Act, which required the clear labeling of ingredients, was passed in 2004. The FDA cites the undeclared presence of allergens as one of the leading reasons for food recalls and a public health issue. "Unfortunately, we're beginning to see evidence that sesame allergies may be a growing...

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Mount Sinai researchers find wheat oral immunotherapy to be therapeutic for allergic patients

(The Mount Sinai Hospital / Mount Sinai School of Medicine) In a major step towards understanding the safety and efficacy of wheat oral immunotherapy, Mount Sinai researchers report promising results from the first multicenter, rigorous clinical trial in the Journal of Allergy and Clinical Immunology. (Source: EurekAlert! - Biology)

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New Concerns About Sesame Allergies

(CNN) — Sesame could become the newest allergen added to the list of foods required to be named on labels, US Food and Drug Administration Commissioner Dr. Scott Gottlieb announced Monday. Eight major food allergens must currently be declared on US labeling using their common names: milk, eggs, fish, shellfish, tree nuts, peanuts, wheat and soybeans. These foods accounted for over 90% of documented serious food allergies in the country when the Food Allergen Labeling and Consumer Protection Act, which required the clear labeling of ingredients, was passed in 2004. The FDA cites the undeclared presence of allergens as one of the leading reasons for food recalls and a public health issue. "Unfortunately, we're beginning to see evidence that sesame allergies may be a growing...

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Mount Sinai researchers find wheat oral immunotherapy to be therapeutic for allergic patients

(The Mount Sinai Hospital / Mount Sinai School of Medicine) In a major step towards understanding the safety and efficacy of wheat oral immunotherapy, Mount Sinai researchers report promising results from the first multicenter, rigorous clinical trial in the Journal of Allergy and Clinical Immunology. (Source: EurekAlert! - Biology)

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Beyond “See One, Do One, Teach One”

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Beyond “See One, Do One, Teach One”

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Calcitonin measurement in fine-needle aspirate washout fluid by electrochemiluminescence immunoassay for thyroid tumors

Abstract

Purpose

For the differential diagnosis of medullary thyroid carcinoma (MTC) on thyroid nodules, ultrasound-guided fine-needle aspiration cytology is a useful and safe procedure, but its diagnostic accuracy is not high enough. As an ancillary method to accurately diagnose MTC, the calcitonin in fine-needle aspirate washout fluid (FNA-Ct) is used. However, no data are available about cut-off values of FNA-Ct using the currently available electrochemiluminescence immunoassay (ECLIA).

Methods

We investigated 180 thyroid nodules in 141 patients. After smearing, the syringe and needle used for the FNA were rinsed with normal saline (0.5 mL). The calcitonin in the washout was measured by ECLIA.

Results

The FNA-Ct in the non-MTC nodules of MTC patients, non-MTC nodules of non-MTC patients, and MTC nodules were 10.6–2100 pg/mL (median 24.6 pg/mL), < 0.5–21.0 pg/mL (median < 0.5 pg/mL), and 94.9–4,070,000 pg/mL (median 177,000 pg/mL), respectively. A receiver operating characteristic analysis of the MTC nodules and the non-MTC nodules of the non-MTC patients indicated that the cut-off value was 21.0 pg/mL, leading to 100% sensitivity and 100% specificity.

Conclusions

This is the first study to determine the cut-off value of FNA-Ct with an ECLIA, and we propose that the optimal cut-off value is 21.0 pg/mL.

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