Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Yan Zhou, CaiXia Hao, Chen Li, XiaoTing Huang, XiaoHong Li, YiTing Tang, YanHong Huang, SiYuan Tang, Wei Liu, DanDan Feng, JianPing Xu, ShaoJie Yue, Hui Xie, ZiQiang LuoAbstractAcute lung injury (ALI) is characterized by inflammatory cell infiltration, macrophage activation, and excessive pro-inflammatory cytokine production. Bleomycin (BLM) is widely used to induce acute lung injury (ALI) and fibrosis in murine models. Intratracheally administration of BLM leads to the early stage of inflammatory response and the late stage of collagen deposition. Omentin-1 exerts an anti-inflammatory role in reducing tumor necrosis factor α (TNF-α)-induced cyclooxygenase-2 expression in endothelial cells and attenuating l...
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