Publication date: Available online 18 February 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Mehdi Shakibaie, Maryam Vaezjalali, Hashem Rafii-Tabar, Pezhman SasanpourAbstractDrug resistance as an important barrier in cancer treatment, has a close relation with alteration of cancer metabolism. Therefore, in this study the synergistic effect of phototherapy and chemotherapy were investigated on bladder cancer cells viability. The cytotoxicity effect of blue light irradiation was measured by MTT assay. Glucose consumption, lactate and ammonium formation were analyzed in blue LED-irradiated cancer cells culture. Also, the expression of some genes involved in apoptosis and epithelial–mesenchymal transition was assessed using real-time PCR in comparison with contr...
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