Τρίτη 8 Ιανουαρίου 2019

The Harm Done by Senescent T Cells

Senescent cells accumulate with age in all tissues, and their presence is one of the root causes of aging. Cells become senescent in large numbers at all ages, and under a variety of circumstances: toxins, wound healing, ordinary somatic cells reaching the Hayflick limit, random mutational damage to important genes, and so forth. Senescence irreversibly shuts down cellular replication, making it a useful defense against cancer. Near all newly senescent cells are destroyed quickly. They either self-destruct or they are destroyed by the immune system, but both paths to a reliable natural clearance of senescent cells falter with the damage and dysfunction of aging. Lingering senescent cells that have evaded destruction never rise to more than a few percent of all cells by number, even ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RG6erG

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