Κυριακή 16 Σεπτεμβρίου 2018
Scientists map interactions between head and neck cancer and HPV virus
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Scientists map interactions between head and neck cancer and HPV virus
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Promyelocytic leukemia zinc finger triggers ATP-binding cassette subfamily E member 1-mediated growth inhibition in breast cancer cells.
Authors: Suliman BA, Al-Yahya S Abstract The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor that is involved in a number of biological processes, including those regulating cellular growth; however, little is known regarding how it achieves its inhibitory effect in different cell and tissue types. It has previously been demonstrated that PLZF expression levels become diminished during the oncogenic transformation of certain tissue types and thus, may serve as a hallmark for tumor aggressiveness. To examine this in breast cancer, survival curves from available oncology databases were analyzed and demonstrated that PLZF expression was positively associated with increased survival in patients with breast cancer. The mRNA and protein levels of PLZF were als...
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Promyelocytic leukemia zinc finger triggers ATP-binding cassette subfamily E member 1-mediated growth inhibition in breast cancer cells.
Authors: Suliman BA, Al-Yahya S Abstract The promyelocytic leukemia zinc finger (PLZF) protein is a transcription factor that is involved in a number of biological processes, including those regulating cellular growth; however, little is known regarding how it achieves its inhibitory effect in different cell and tissue types. It has previously been demonstrated that PLZF expression levels become diminished during the oncogenic transformation of certain tissue types and thus, may serve as a hallmark for tumor aggressiveness. To examine this in breast cancer, survival curves from available oncology databases were analyzed and demonstrated that PLZF expression was positively associated with increased survival in patients with breast cancer. The mRNA and protein levels of PLZF were als...
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Polymorphisms in P53 and VEGFA genes in different subtypes of periorbital hyperpigmentation in a Malaysian Chinese population.
CONCLUSION: Mixed subtype was the most prevalent type of periorbital hyperpigmentation in the study population. Three polymorphisms in p53 and VEGFA genes were statistically linked with different clinical presentations of periorbital hyperpigmentation. PMID: 30215845 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
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Polymorphisms in P53 and VEGFA genes in different subtypes of periorbital hyperpigmentation in a Malaysian Chinese population.
CONCLUSION: Mixed subtype was the most prevalent type of periorbital hyperpigmentation in the study population. Three polymorphisms in p53 and VEGFA genes were statistically linked with different clinical presentations of periorbital hyperpigmentation. PMID: 30215845 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
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Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...
| Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ... TokeNexaFull coverage |
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Follicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025
| Follicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025 Redfield Herald (press release) (blog)Full coverage |
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Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...
| Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ... TokeNexaFull coverage |
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Follicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025
| Follicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025 Redfield Herald (press release) (blog)Full coverage |
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Protective effect of N-acetylcysteine against cisplatin ototoxicity in rats: a study with hearing tests and scanning electron microscopy
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Protective effect of N-acetylcysteine against cisplatin ototoxicity in rats: a study with hearing tests and scanning electron microscopy
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Allergic reactions in oral and perioral diseases—what do allergy skin test results show?
ConclusionsAllergy skin tests are reliable and justified for diagnosing allergies in cases of persistent or recurrent oral diseases. This is the only way to confirm allergies and is the basis for consequent allergen avoidance for the benefit of the patient. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
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Screening the full leukocyte receptor complex (LRC) region revealed associations with pemphigus that might be explained by gene regulation.
This article is protected by copyright. All rights reserved. PMID: 30216441 [PubMed - as supplied by publisher] (Source: Immunology)
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Allergic reactions in oral and perioral diseases—what do allergy skin test results show?
ConclusionsAllergy skin tests are reliable and justified for diagnosing allergies in cases of persistent or recurrent oral diseases. This is the only way to confirm allergies and is the basis for consequent allergen avoidance for the benefit of the patient. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
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Screening the full leukocyte receptor complex (LRC) region revealed associations with pemphigus that might be explained by gene regulation.
This article is protected by copyright. All rights reserved. PMID: 30216441 [PubMed - as supplied by publisher] (Source: Immunology)
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Insights into adsorption behaviour of binary liquid mixtures in porous media using fast field cycling NMR
Publication date: Available online 16 September 2018
Source: Magnetic Resonance Imaging
Author(s): J. Ward-Williams, L.F. Gladden
Abstract
Fast field cycling, FFC, NMR relaxometry experiments are reported in the frequency range of 10 kHz–40 MHz to characterise the adsorption behaviour of cyclohexane:THF (non-polar:polar) and THF:methanol (polar:polar) binary liquid mixtures adsorbed on a γ-alumina surface of catalytic interest. Laplace inversion of the relaxation rate data is employed to identify the chemical species in the binary mixture. In both systems studied, the more polar molecule preferentially interacts with the surface compared to the co-imbibed species. The relaxation rate data were analysed to explore the relative influences of surface dynamics and surface accessibility on the observed relaxation rates. For both binary systems, the change in relaxation behaviour with composition is interpreted as a change in the surface accessibility of each species caused by a micro-phase separation at the pore surface.
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Fast spatially-resolved T2 measurements with constant-gradient CPMG
Publication date: Available online 15 September 2018
Source: Magnetic Resonance Imaging
Author(s): Stefan A. Hertel, Daan W. de Kort, Isabelle Bush, Andrew J. Sederman, Lynn F. Gladden, Benjamin Anger, Hilko de Jong, Matthias Appel
Abstract
Speed of acquisition is paramount for the application of magnetic resonance to flow experiments through porous rocks. One popular method for imaging core floods is the spatially resolved T2 experiment which can separate fluids either by their viscosity contrast or by doping one fluid with a relaxation agent. Existing techniques for spatial-T2 may suffer from long acquisition times and eddy currents due to the pulsing of magnetic field gradients. Here, we propose a constant gradient method for 1d spatially-resolved T2 which embraces the speed of frequency encoding techniques and avoids eddy currents by the absence of any gradient ramps during the radio frequency (r.f.) pulse train. We provide the operating envelope for this kind of experiment, which is restricted due to the slice selectivity of the r.f. pulses in the presence of the magnetic field gradient. Additionally, we show that the effects of self-diffusion and the mixing of T1 and T2 contributions are manageable. As an illustration, we have applied this technique to an enhanced oil recovery experiment. The two fluid phases were tracked without any doping and with a time resolution of 40 s. In this case, the increased time resolution allowed us to observe dynamic flow phenomena such as fluid fingering and the calculation of the velocity of the fluid displacement fronts.
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Insights into adsorption behaviour of binary liquid mixtures in porous media using fast field cycling NMR
Publication date: Available online 16 September 2018
Source: Magnetic Resonance Imaging
Author(s): J. Ward-Williams, L.F. Gladden
Abstract
Fast field cycling, FFC, NMR relaxometry experiments are reported in the frequency range of 10 kHz–40 MHz to characterise the adsorption behaviour of cyclohexane:THF (non-polar:polar) and THF:methanol (polar:polar) binary liquid mixtures adsorbed on a γ-alumina surface of catalytic interest. Laplace inversion of the relaxation rate data is employed to identify the chemical species in the binary mixture. In both systems studied, the more polar molecule preferentially interacts with the surface compared to the co-imbibed species. The relaxation rate data were analysed to explore the relative influences of surface dynamics and surface accessibility on the observed relaxation rates. For both binary systems, the change in relaxation behaviour with composition is interpreted as a change in the surface accessibility of each species caused by a micro-phase separation at the pore surface.
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Fast spatially-resolved T2 measurements with constant-gradient CPMG
Publication date: Available online 15 September 2018
Source: Magnetic Resonance Imaging
Author(s): Stefan A. Hertel, Daan W. de Kort, Isabelle Bush, Andrew J. Sederman, Lynn F. Gladden, Benjamin Anger, Hilko de Jong, Matthias Appel
Abstract
Speed of acquisition is paramount for the application of magnetic resonance to flow experiments through porous rocks. One popular method for imaging core floods is the spatially resolved T2 experiment which can separate fluids either by their viscosity contrast or by doping one fluid with a relaxation agent. Existing techniques for spatial-T2 may suffer from long acquisition times and eddy currents due to the pulsing of magnetic field gradients. Here, we propose a constant gradient method for 1d spatially-resolved T2 which embraces the speed of frequency encoding techniques and avoids eddy currents by the absence of any gradient ramps during the radio frequency (r.f.) pulse train. We provide the operating envelope for this kind of experiment, which is restricted due to the slice selectivity of the r.f. pulses in the presence of the magnetic field gradient. Additionally, we show that the effects of self-diffusion and the mixing of T1 and T2 contributions are manageable. As an illustration, we have applied this technique to an enhanced oil recovery experiment. The two fluid phases were tracked without any doping and with a time resolution of 40 s. In this case, the increased time resolution allowed us to observe dynamic flow phenomena such as fluid fingering and the calculation of the velocity of the fluid displacement fronts.
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TMP778, a selective inhibitor of ROR γt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
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A hyperactive mutant of Interferon ‐Regulatory‐Factor 4
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
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Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor
Clinical&Experimental Allergy,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Allergy)
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TMP778, a selective inhibitor of ROR γt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations.
This article is protected by copyright. All rights reserved. PMID: 30218573 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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A hyperactive mutant of Interferon-Regulatory-Factor 4.
Authors: Kang CH, Hartmann E, Menke L, Staudenraus D, Abass EF, Raifer H, Porapu A, Camara B, Brüstle A, Pinkenburg O, Bieringer M, Lohoff M Abstract IRFs are a family of transcription factors with pleiotropic functions in immune cells, including in generation of subsets of DCs and macrophages and B cell maturation [1]. IRF1 deficiency results in strongly diminished Th1 responses [2] and an inability to counteract pro-asthmatic Th9 responses [3]. PMID: 30218581 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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Prophylactic treatment against GM-CSF, but not IL-17, abolishes relapses in a chronic murine model of multiple sclerosis.
This article is protected by copyright. All rights reserved. PMID: 30216414 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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TMP778, a selective inhibitor of ROR γt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
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A hyperactive mutant of Interferon ‐Regulatory‐Factor 4
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
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Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor
Clinical&Experimental Allergy,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Allergy)
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TMP778, a selective inhibitor of ROR γt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations.
This article is protected by copyright. All rights reserved. PMID: 30218573 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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A hyperactive mutant of Interferon-Regulatory-Factor 4.
Authors: Kang CH, Hartmann E, Menke L, Staudenraus D, Abass EF, Raifer H, Porapu A, Camara B, Brüstle A, Pinkenburg O, Bieringer M, Lohoff M Abstract IRFs are a family of transcription factors with pleiotropic functions in immune cells, including in generation of subsets of DCs and macrophages and B cell maturation [1]. IRF1 deficiency results in strongly diminished Th1 responses [2] and an inability to counteract pro-asthmatic Th9 responses [3]. PMID: 30218581 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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Prophylactic treatment against GM-CSF, but not IL-17, abolishes relapses in a chronic murine model of multiple sclerosis.
This article is protected by copyright. All rights reserved. PMID: 30216414 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research The Patriot LedgerFull coverage |
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research The Patriot LedgerFull coverage |
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Coping with stress, control of emotions and biochemical markers as a common protective element in the inflammatory response to stress.
CONCLUSIONS: In difficult situations, accompanied by an increase in the variables responsible for the biochemical inflammatory response of an organism, the effective model of coping with difficult situations and emotioncontrol increases, while the subjective level of perceived stress drops. PMID: 30218566 [PubMed - in process] (Source: Psychiatria Polska)
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The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model
In conclusion, this study suggests that GW0742 corrects neurobehavioral dysfunction in BTBR mice which is concurrent with modulation of multiple signaling pathways. (Source: Neurochemistry International)
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Statins influence epithelial expression of the antimicrobial peptide LL-37/hCAP-18 independently of the mevalonate pathway.
This article is protected by copyright. All rights reserved. PMID: 30216432 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for Rheumatoid Arthritis.
This study suggests that the hsa_circ_0044235 in peripheral blood may be a potential biomarker of patients with RA. This article is protected by copyright. All rights reserved. PMID: 30216431 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Clinical & laboratory features of seventy-eight UK patients with Good's syndrome (thymoma & hypogammaglobulinemia).
This article is protected by copyright. All rights reserved. PMID: 30216434 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Coping with stress, control of emotions and biochemical markers as a common protective element in the inflammatory response to stress.
CONCLUSIONS: In difficult situations, accompanied by an increase in the variables responsible for the biochemical inflammatory response of an organism, the effective model of coping with difficult situations and emotioncontrol increases, while the subjective level of perceived stress drops. PMID: 30218566 [PubMed - in process] (Source: Psychiatria Polska)
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The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model
In conclusion, this study suggests that GW0742 corrects neurobehavioral dysfunction in BTBR mice which is concurrent with modulation of multiple signaling pathways. (Source: Neurochemistry International)
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Statins influence epithelial expression of the antimicrobial peptide LL-37/hCAP-18 independently of the mevalonate pathway.
This article is protected by copyright. All rights reserved. PMID: 30216432 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for Rheumatoid Arthritis.
This study suggests that the hsa_circ_0044235 in peripheral blood may be a potential biomarker of patients with RA. This article is protected by copyright. All rights reserved. PMID: 30216431 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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Clinical & laboratory features of seventy-eight UK patients with Good's syndrome (thymoma & hypogammaglobulinemia).
This article is protected by copyright. All rights reserved. PMID: 30216434 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
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QUANTITATIVE ASSESSMENT OF PULMONARY VASCULAR ALTERATIONS IN CHRONIC OBSTRUCTIVE LUNG DISEASE: ASSOCIATIONS WITH PULMONARY FUNCTION TEST AND SURVIVAL IN THE KOLD COHORT
Publication date: Available online 15 September 2018
Source: European Journal of Radiology
Author(s): Young Hoon Cho, Sang Min Lee, Joon Beom Seo, Namkug Kim, Jang Pyo Bae, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee
Abstract
Purpose
Despite the high prevalence of pulmonary vascular alterations and their substantial impact on chronic obstructive pulmonary disease (COPD), tools for the direct in vivo assessment of pulmonary vascular alterations remain limited. Thus, the purpose of this study was to automatically extract pulmonary vessels from volumetric chest CT and evaluate the associations between the derived quantitative pulmonary vessel features and clinical parameters, including survival, in COPD patients.
Methods
This study included 344 adult COPD patients. Pulmonary vessels were automatically extracted from volumetric chest CT data. Quantitative pulmonary vessel features were obtained from various lung surface areas (LSAs), which are theoretical surface areas drawn at different depths from the pleural borders. The total number of vessels (Ntotal) and number of vessels with vessel area (VA) less than 5 mm2 (N<5mm) were counted as both robust values and as values per 10 cm2 of LSA (Ntotal/LSA; N<5mm/LSA). The average VA (VAmean) and percentage of measured VA in the corresponding LSA (%VA) were measured. Associations between quantitative pulmonary vessel features and clinical parameters, including survival and the pulmonary function test (PFT), were evaluated.
Results
The pulmonary vessels were automatically extracted with 100% technical success. Cox regression analysis showed Ntotal/LSA, N<5mm/LSA, VAmean, and %VA to be significant predictors of survival (hazard ratio (HR), 0.80, 0.75, 0.70, 0.49, respectively). Patients classified into high-risk groups by %VA18mm (cut-off = 3.258), chosen because it demonstrated the strongest statistical influence on survival in a univariate Cox analysis, were associated with worse overall survival before (HR, 4.83; p < 0.001) and after adjustment for patient age and BMI (HR, 2.18; p = 0.014). Of the quantitative pulmonary vessel features, Ntotal/LSA, N<5mm/LSA, and %VA were correlated with FEV1, FEV1/FVC, and DLCO in all LSAs. The strongest correlation with PFTs was noted at LSA9mm for both Ntotal (FEV1, r = 0.33; FEV1/FVC, r = 0.51) and N<5mm (FEV1, r = 0.35; FEV1/FVC, r = 0.52). For %VA, the association was most evident at LSA18mm (FEV1, r = 0.27; FEV1/FVC, r = 0.47). Significant moderate to strong correlations were consistently observed between the extent of emphysema and quantitative pulmonary vessel features (r = 0.44–0.66; all p < 0.001).
Conclusions
The automated extraction of pulmonary vessels and their quantitative assessment are technically feasible. Various quantitative pulmonary vessel features demonstrated significant relationships with survival and PFT in COPD patients. Of the various quantitative features, the percentage of total VA measured at 18 mm depth from the pleural surface (%VA18mm) and the number of small vessels counted per 10 cm2 of LSA at 9 mm depth from the pleural surface (N<5mm/LSA9mm) had the strongest predictability for the clinical parameters.
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QUANTITATIVE ASSESSMENT OF PULMONARY VASCULAR ALTERATIONS IN CHRONIC OBSTRUCTIVE LUNG DISEASE: ASSOCIATIONS WITH PULMONARY FUNCTION TEST AND SURVIVAL IN THE KOLD COHORT
Publication date: Available online 15 September 2018
Source: European Journal of Radiology
Author(s): Young Hoon Cho, Sang Min Lee, Joon Beom Seo, Namkug Kim, Jang Pyo Bae, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee
Abstract
Purpose
Despite the high prevalence of pulmonary vascular alterations and their substantial impact on chronic obstructive pulmonary disease (COPD), tools for the direct in vivo assessment of pulmonary vascular alterations remain limited. Thus, the purpose of this study was to automatically extract pulmonary vessels from volumetric chest CT and evaluate the associations between the derived quantitative pulmonary vessel features and clinical parameters, including survival, in COPD patients.
Methods
This study included 344 adult COPD patients. Pulmonary vessels were automatically extracted from volumetric chest CT data. Quantitative pulmonary vessel features were obtained from various lung surface areas (LSAs), which are theoretical surface areas drawn at different depths from the pleural borders. The total number of vessels (Ntotal) and number of vessels with vessel area (VA) less than 5 mm2 (N<5mm) were counted as both robust values and as values per 10 cm2 of LSA (Ntotal/LSA; N<5mm/LSA). The average VA (VAmean) and percentage of measured VA in the corresponding LSA (%VA) were measured. Associations between quantitative pulmonary vessel features and clinical parameters, including survival and the pulmonary function test (PFT), were evaluated.
Results
The pulmonary vessels were automatically extracted with 100% technical success. Cox regression analysis showed Ntotal/LSA, N<5mm/LSA, VAmean, and %VA to be significant predictors of survival (hazard ratio (HR), 0.80, 0.75, 0.70, 0.49, respectively). Patients classified into high-risk groups by %VA18mm (cut-off = 3.258), chosen because it demonstrated the strongest statistical influence on survival in a univariate Cox analysis, were associated with worse overall survival before (HR, 4.83; p < 0.001) and after adjustment for patient age and BMI (HR, 2.18; p = 0.014). Of the quantitative pulmonary vessel features, Ntotal/LSA, N<5mm/LSA, and %VA were correlated with FEV1, FEV1/FVC, and DLCO in all LSAs. The strongest correlation with PFTs was noted at LSA9mm for both Ntotal (FEV1, r = 0.33; FEV1/FVC, r = 0.51) and N<5mm (FEV1, r = 0.35; FEV1/FVC, r = 0.52). For %VA, the association was most evident at LSA18mm (FEV1, r = 0.27; FEV1/FVC, r = 0.47). Significant moderate to strong correlations were consistently observed between the extent of emphysema and quantitative pulmonary vessel features (r = 0.44–0.66; all p < 0.001).
Conclusions
The automated extraction of pulmonary vessels and their quantitative assessment are technically feasible. Various quantitative pulmonary vessel features demonstrated significant relationships with survival and PFT in COPD patients. Of the various quantitative features, the percentage of total VA measured at 18 mm depth from the pleural surface (%VA18mm) and the number of small vessels counted per 10 cm2 of LSA at 9 mm depth from the pleural surface (N<5mm/LSA9mm) had the strongest predictability for the clinical parameters.
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Otological surgery in paediatric photosensitive patients
Publication date: Available online 15 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): James Bates, Andy Hall, Thushitha Kunanandam, Richard Hewitt
Abstract
There are a wide range of genetic and auto-immune conditions where UV light exposure poses a threat of UV irradiation to the external auditory canal, tympanic membrane and surrounding skin. Preoperative Ultraviolet Light (UV) measurements were taken in the operating theatre with standard operating microscope and an approved UV light meter prior to surgery on a patient with xeroderma pigmentosa. UV light meter readings of UV index 75 were taken at an operating distance of 290mm. Proceeding with otological surgery with a high UV index would result in a significant UV radiation burn. Utilising a Dermagard and a specific UV filter applied to the microscope resulted in acceptable UV light readings. We highlight the potential morbidity of otological surgery in paediatric photosensitive conditions. We also recommend a management plan to avoid damage by UV radiation in photosensitive patients.
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Otological surgery in paediatric photosensitive patients
Publication date: Available online 15 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): James Bates, Andy Hall, Thushitha Kunanandam, Richard Hewitt
Abstract
There are a wide range of genetic and auto-immune conditions where UV light exposure poses a threat of UV irradiation to the external auditory canal, tympanic membrane and surrounding skin. Preoperative Ultraviolet Light (UV) measurements were taken in the operating theatre with standard operating microscope and an approved UV light meter prior to surgery on a patient with xeroderma pigmentosa. UV light meter readings of UV index 75 were taken at an operating distance of 290mm. Proceeding with otological surgery with a high UV index would result in a significant UV radiation burn. Utilising a Dermagard and a specific UV filter applied to the microscope resulted in acceptable UV light readings. We highlight the potential morbidity of otological surgery in paediatric photosensitive conditions. We also recommend a management plan to avoid damage by UV radiation in photosensitive patients.
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research MetroWest Daily NewsFull coverage |
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The error-related negativity for error processing in interoception
Publication date: Available online 15 September 2018
Source: NeuroImage
Author(s): Yafei Tan, Jolien Vandeput, Jiang Qiu, Omer Van den Bergh, Andreas von Leupoldt
Abstract
The error-related negativity (ERN) is an event-related potential in the electroencephalogram (EEG) observed within the first 100 ms after commission of an error. Increased ERN amplitudes have been observed in several psychological disorders characterized by high negative affect. While the ERN has extensively been studied in tasks using exteroceptive stimuli, its relation to interoceptive stimuli is unknown. Since errors related to interoception might be particularly relevant for survival and negative affect, this study aimed to explore the ERN for errors related to interoceptive, respiratory sensations (intERN). Moreover, we compared the intERN with a commonly observed ERN related to exteroceptive, visual stimuli (extERN) and examined their associations with interoception-related negative affect. We studied the ERN using a respiratory occlusion task (intERN) and a visual flanker task (extERN) in 40 healthy volunteers during continuous 129 channel EEG recordings. In the occlusion task, participants received inspiratory occlusions of two different durations and indicated whether each occlusion was short or long. In the Flanker task, participants indicated the direction of arrowheads. Interoception-related negative affect was assessed with the Anxiety Sensitivity Index. Comparable with the extERN, the intERN was observed at fronto-central scalp positions after error commission in the occlusion task, but it peaked significantly earlier than the extERN. Mean amplitudes of the intERN and extERN showed no significant difference and were not correlated. Moreover, higher levels of anxiety sensitivity were correlated with significantly greater amplitudes of the intERN, but with lower amplitudes of the extERN. The present results firstly demonstrate an error-related negativity EEG-potential that is related to interoceptive sensations (intERN). This intERN is not associated with a commonly observed ERN elicited by exteroceptive stimuli and is distinctly linked to higher levels of interoception-related negative affect. The intERN might be a promising neural marker for future studies on interoception, negative affect and error processing.
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research MetroWest Daily NewsFull coverage |
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xieguG
The error-related negativity for error processing in interoception
Publication date: Available online 15 September 2018
Source: NeuroImage
Author(s): Yafei Tan, Jolien Vandeput, Jiang Qiu, Omer Van den Bergh, Andreas von Leupoldt
Abstract
The error-related negativity (ERN) is an event-related potential in the electroencephalogram (EEG) observed within the first 100 ms after commission of an error. Increased ERN amplitudes have been observed in several psychological disorders characterized by high negative affect. While the ERN has extensively been studied in tasks using exteroceptive stimuli, its relation to interoceptive stimuli is unknown. Since errors related to interoception might be particularly relevant for survival and negative affect, this study aimed to explore the ERN for errors related to interoceptive, respiratory sensations (intERN). Moreover, we compared the intERN with a commonly observed ERN related to exteroceptive, visual stimuli (extERN) and examined their associations with interoception-related negative affect. We studied the ERN using a respiratory occlusion task (intERN) and a visual flanker task (extERN) in 40 healthy volunteers during continuous 129 channel EEG recordings. In the occlusion task, participants received inspiratory occlusions of two different durations and indicated whether each occlusion was short or long. In the Flanker task, participants indicated the direction of arrowheads. Interoception-related negative affect was assessed with the Anxiety Sensitivity Index. Comparable with the extERN, the intERN was observed at fronto-central scalp positions after error commission in the occlusion task, but it peaked significantly earlier than the extERN. Mean amplitudes of the intERN and extERN showed no significant difference and were not correlated. Moreover, higher levels of anxiety sensitivity were correlated with significantly greater amplitudes of the intERN, but with lower amplitudes of the extERN. The present results firstly demonstrate an error-related negativity EEG-potential that is related to interoceptive sensations (intERN). This intERN is not associated with a commonly observed ERN elicited by exteroceptive stimuli and is distinctly linked to higher levels of interoception-related negative affect. The intERN might be a promising neural marker for future studies on interoception, negative affect and error processing.
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Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
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FDA to review application to modify health warning on Altria subsidiary’s smokeless tobacco product
Source: www.richmond.com Author: staff The U.S. Food and Drug Administration will review a request from an Altria Group Inc. subsidiary that […]
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Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NfDTah
FDA to review application to modify health warning on Altria subsidiary’s smokeless tobacco product
Source: www.richmond.com Author: staff The U.S. Food and Drug Administration will review a request from an Altria Group Inc. subsidiary that […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OtzRaU
Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NfDTah
FDA to review application to modify health warning on Altria subsidiary’s smokeless tobacco product
Source: www.richmond.com Author: staff The U.S. Food and Drug Administration will review a request from an Altria Group Inc. subsidiary that […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OtzRaU
Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NfDTah
FDA to review application to modify health warning on Altria subsidiary’s smokeless tobacco product
Source: www.richmond.com Author: staff The U.S. Food and Drug Administration will review a request from an Altria Group Inc. subsidiary that […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OtzRaU
Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
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Comparison of extrusion and patency of silicon versus thermoplastic elastomer tympanostomy tubes
Publication date: Available online 15 September 2018
Source: Auris Nasus Larynx
Author(s): Dongwon Kim, Sung-Won Choi, Hyun-Min Lee, Soo-Keun Kong, Il-Woo Lee, Se-Joon Oh
Abstract
Objectives
This study aimed to assess the differences in the extrusion rate, patency and incidence of otorrhea according to the material properties of tubes in tympanostomy tube (TT) procedures.
Subjects and methods
A total of 75 children with bilateral chronic otitis media with effusion were randomized in this prospective trial to receive 1.02-mm-sized TTs (thermoplastic elastomer) in one ear and 1.14-mm-sized TTs (silicone) in the other ear. Data were obtained on ventilation tube type, time to extrusion, comorbidities, tube plugging, incidence of TT otorrhea during following up, and age of the patient. Postoperatively, follow-up by an otologist continued every two months to assess the incidence of otorrhea, plugging, and TT extrusion until all tubes were extruded.
Results
Out of the 75 children, 7 patients were excluded during surgery and 4 were lost during follow-up. The mean extrusion time of 1.02-mm-sized TTs (thermoplastic elastomer) was 10.28 months, whereas that of 1.14-mm-sized TTs (silicone) was 7.36 months, which showed a significant difference. However, thermoplastic elastomer TTs had more plugging events than silicone TTs.
Conclusions
There was a significant increase in the time to extrusion in ears with the 1.02-mm-sized thermoplastic elastomer TT, although, generally, the larger inner diameter of the tube last longer in the eardrum. This contrasting result is thought to be due to the different material properties of both TTs. This information may be helpful for TT selection in clinical practice depending on the patient's condition.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MBaS3R
Men with more than two oral sex partners are more likely to contract HPV
Source: www.nzherald.co.nz Author: Rebecca Sullivan Men who have had more than two oral sex partners are "significantly" more likely to contract […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NfDTah
Comparison of extrusion and patency of silicon versus thermoplastic elastomer tympanostomy tubes
Publication date: Available online 15 September 2018
Source: Auris Nasus Larynx
Author(s): Dongwon Kim, Sung-Won Choi, Hyun-Min Lee, Soo-Keun Kong, Il-Woo Lee, Se-Joon Oh
Abstract
Objectives
This study aimed to assess the differences in the extrusion rate, patency and incidence of otorrhea according to the material properties of tubes in tympanostomy tube (TT) procedures.
Subjects and methods
A total of 75 children with bilateral chronic otitis media with effusion were randomized in this prospective trial to receive 1.02-mm-sized TTs (thermoplastic elastomer) in one ear and 1.14-mm-sized TTs (silicone) in the other ear. Data were obtained on ventilation tube type, time to extrusion, comorbidities, tube plugging, incidence of TT otorrhea during following up, and age of the patient. Postoperatively, follow-up by an otologist continued every two months to assess the incidence of otorrhea, plugging, and TT extrusion until all tubes were extruded.
Results
Out of the 75 children, 7 patients were excluded during surgery and 4 were lost during follow-up. The mean extrusion time of 1.02-mm-sized TTs (thermoplastic elastomer) was 10.28 months, whereas that of 1.14-mm-sized TTs (silicone) was 7.36 months, which showed a significant difference. However, thermoplastic elastomer TTs had more plugging events than silicone TTs.
Conclusions
There was a significant increase in the time to extrusion in ears with the 1.02-mm-sized thermoplastic elastomer TT, although, generally, the larger inner diameter of the tube last longer in the eardrum. This contrasting result is thought to be due to the different material properties of both TTs. This information may be helpful for TT selection in clinical practice depending on the patient's condition.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MBaS3R
FDA to review application to modify health warning on Altria subsidiary’s smokeless tobacco product
Source: www.richmond.com Author: staff The U.S. Food and Drug Administration will review a request from an Altria Group Inc. subsidiary that […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OtzRaU
FDA to review application to modify health warning on Altria subsidiary’s smokeless tobacco product
Source: www.richmond.com Author: staff The U.S. Food and Drug Administration will review a request from an Altria Group Inc. subsidiary that […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OtzRaU
What to Look for on Post-stroke Neuroimaging
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Angelos M. Katramados, Lotfi Hacein-Bey, Panayiotis N. Varelas
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Computed Tomography, Computed Tomography Angiography, and Perfusion Computed Tomography Evaluation of Acute Ischemic Stroke
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Carlos Leiva-Salinas, Bin Jiang, Max Wintermark
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MR Imaging Selection of Acute Stroke Patients with Emergent Large Vessel Occlusions for Thrombectomy
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Thabele M. Leslie-Mazwi, Michael H. Lev, Pamela W. Schaefer, Joshua A. Hirsch, R. Gilberto González
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Clot Pathophysiology: Why Is It Clinically Important?
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Patrick A. Brouwer, Waleed Brinjikji, Simon F. De Meyer
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Advanced Neuroimaging of Acute Ischemic Stroke: Penumbra and Collateral Assessment
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Jeremy J. Heit, Greg Zaharchuk, Max Wintermark
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What to Look for on Post-stroke Neuroimaging
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Angelos M. Katramados, Lotfi Hacein-Bey, Panayiotis N. Varelas
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Computed Tomography, Computed Tomography Angiography, and Perfusion Computed Tomography Evaluation of Acute Ischemic Stroke
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Carlos Leiva-Salinas, Bin Jiang, Max Wintermark
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MR Imaging Selection of Acute Stroke Patients with Emergent Large Vessel Occlusions for Thrombectomy
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Thabele M. Leslie-Mazwi, Michael H. Lev, Pamela W. Schaefer, Joshua A. Hirsch, R. Gilberto González
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Clot Pathophysiology: Why Is It Clinically Important?
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Patrick A. Brouwer, Waleed Brinjikji, Simon F. De Meyer
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Advanced Neuroimaging of Acute Ischemic Stroke: Penumbra and Collateral Assessment
Publication date: Available online 15 September 2018
Source: Neuroimaging Clinics of North America
Author(s): Jeremy J. Heit, Greg Zaharchuk, Max Wintermark
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Quantitative analysis of biofilm bacteria according to different stages of early childhood caries
Publication date: Available online 15 September 2018
Source: Archives of Oral Biology
Author(s): Beatriz Gonçalves Neves, Rafael Nóbrega Stipp, Daniela da Silva Bezerra, Sarah Florindo de Figueiredo Guedes, Lidiany Karla Azevedo Rodrigues, B.G. Neves, R.N. Stipp, D.S. Bezerra, S.F.F. Guedes, L.K.A. Rodrigues
ABSTRACT
Objective
Monitoring selected key species related to health or diseases may facilitate caries risk assessment and discovery of novel ecological preventive and therapeutic approaches. This study aimed at quantifyingActinomyces naeslundii, Bifidobacterium spp., Lactobacillus acidophilus, Lactobacillus casei group, Streptococcus gordonii, Mitis group and Streptococcus mutans by quantitative polymerase chain reaction (qPCR) in dental biofilm from Brazilian children with different stages of early childhood caries (ECC).
Design
Seventy-five preschool children were clinically evaluated by ICDAS criteria and divided into groups: caries-free (CF; n = 20), enamel caries lesions (ECL; n = 17) and dentine caries lesions (DCL; n = 38). Plaque sample from all children was collected for detection and quantification of the selected bacteria.
Results
L. acidophilus and L. casei group were absent in almost all plaque samples. No differences in relative proportions of A. naeslundii, Mitis group and S. gordonii were observed in any stage of caries. However, S. mutans and Bifidobacterium spp. were present at higher concentrations in the biofilm of children with DCL (p < 0.001). Multivariate analysis showed that S. mutans and Bifidobacterium spp. were strongly associated with biofilm in children with DCL.
Conclusion
Differences were observed in the proportion of acidogenic and aciduric bacteria with dental caries progression. The data indicate thatS. mutans and Bifidobacterium spp. in dental biofilm may be involved in some progression processes for ECC.
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Quantitative analysis of biofilm bacteria according to different stages of early childhood caries
Publication date: Available online 15 September 2018
Source: Archives of Oral Biology
Author(s): Beatriz Gonçalves Neves, Rafael Nóbrega Stipp, Daniela da Silva Bezerra, Sarah Florindo de Figueiredo Guedes, Lidiany Karla Azevedo Rodrigues, B.G. Neves, R.N. Stipp, D.S. Bezerra, S.F.F. Guedes, L.K.A. Rodrigues
ABSTRACT
Objective
Monitoring selected key species related to health or diseases may facilitate caries risk assessment and discovery of novel ecological preventive and therapeutic approaches. This study aimed at quantifyingActinomyces naeslundii, Bifidobacterium spp., Lactobacillus acidophilus, Lactobacillus casei group, Streptococcus gordonii, Mitis group and Streptococcus mutans by quantitative polymerase chain reaction (qPCR) in dental biofilm from Brazilian children with different stages of early childhood caries (ECC).
Design
Seventy-five preschool children were clinically evaluated by ICDAS criteria and divided into groups: caries-free (CF; n = 20), enamel caries lesions (ECL; n = 17) and dentine caries lesions (DCL; n = 38). Plaque sample from all children was collected for detection and quantification of the selected bacteria.
Results
L. acidophilus and L. casei group were absent in almost all plaque samples. No differences in relative proportions of A. naeslundii, Mitis group and S. gordonii were observed in any stage of caries. However, S. mutans and Bifidobacterium spp. were present at higher concentrations in the biofilm of children with DCL (p < 0.001). Multivariate analysis showed that S. mutans and Bifidobacterium spp. were strongly associated with biofilm in children with DCL.
Conclusion
Differences were observed in the proportion of acidogenic and aciduric bacteria with dental caries progression. The data indicate thatS. mutans and Bifidobacterium spp. in dental biofilm may be involved in some progression processes for ECC.
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Utilization of Transoral Robotic Surgery (TORS) in patients with Oropharyngeal Squamous Cell Carcinoma and its impact on survival and use of chemotherapy
Publication date: November 2018
Source: Oral Oncology, Volume 86
Author(s): Sujith Baliga, Rafi Kabarriti, Julie Jiang, Vikas Mehta, Chandan Guha, Shalom Kalnicki, Richard V. Smith, Madhur K. Garg
Abstract
Objective
To determine whether patients with Oropharyngeal Squamous Cell Carcinoma (OPSCC) treated with Transoral Robotic Surgery (TORS) have similar survival to patients treated with definitive RT.
Materials and methods
Using the National Cancer Database (NCDB) registry, we identified patients with newly diagnosed clinical T1-T2, N0-N2b OPSCC between 2010 and 2014. A multivariable logistic regression was utilized to determine the association between chemotherapy use and primary treatment modality (TORS vs definitive RT). Kaplan Meier survival analysis was used to estimate overall survival. Propensity score matching was utilized to address selection bias.
Results
We identified 17,150 patients, of which 14,470 (84.4%) received primary RT and 2,680 (15.6%) underwent TORS. The median follow-up for the cohort was 31.4 months. Propensity score matching demonstrated similar 5-year OS for patients treated with either definitive RT or TORS (81% vs 84%, log rank p = 0.10). There was no difference in survival outcomes by treatment selection (TORS or definitive RT) in either HPV positive or HPV negative subtypes. Patients treated with TORS were less likely to receive chemotherapy compared to patients treated with definitive RT and this was also demonstrated in a propensity matched analysis (OR: 0.09, 95%CI 0.078–0.12, p < 0.001). Only 68.4% of TORS treated patients underwent adjuvant RT, compared to 100% of patients in the primary RT cohort (p < 0.001).
Conclusions and relevance
For patients with OPSCC, TORS results in similar OS outcomes and is associated with decreased chemotherapy and RT use compared to definitive RT. Our results demonstrate the feasibility of TORS in a select subgroup of OPSCC patients.
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HPV status predicts for improved survival following chemotherapy in metastatic squamous cell carcinoma of the oropharynx
Publication date: November 2018
Source: Oral Oncology, Volume 86
Author(s): Luke R.G. Pike, William L. Hwang, Trevor J. Royce, Nina N. Sanford, Brandon A. Mahal
Abstract
Objective
We sought to further define prognostic and predictive value of human papillomavirus (HPV) status in metastatic squamous cell carcinoma of the oropharynx (OPC).
Materials and methods
A Surveillance, Epidemiology, and End Results custom database identified 5940 adult patients, >18-years-old, with primary SCCHN and known HPV status, diagnosed from 2013 to 2014. Wilcoxon rank-sum and Mantel-Haenszel χ2 tests compared distributions of continuous and categorical covariates. Fine-Gray competing risks regressions estimated hazard ratios by HPV status, and predictive analyses were performed including the interaction term HPV status × Receipt of Chemotherapy.
Results
182 of 5940 patients (4.0%) had metastatic OPC at diagnosis (106/3925 [2.7%] HPV+ and 76/1894 [4.0%] HPV−). HPV+ disease was prognostic for improved 20-month cancer-specific mortality (CSM) (47.1% vs 72.5%, HR 0.43, 95% CI 0.26–0.74, p = 0.002) on univariable analysis. HPV status was predictive of response to chemotherapy—adjusted HRs for receipt of chemotherapy were 0.11 (95% CI 0.03–0.37) and 0.34 (95% CI 0.18–0.64) for HPV+ versus HPV− disease, respectively (PHPV status∗Chemotherapy = 0.036).
Conclusion
HPV status has known prognostic value in locally advanced OPC, but data on metastatic OPC are sparse. In this work, we demonstrate that HPV status is strongly prognostic for CSM in metastatic OPC and show for the first time that HPV status predicts for response to chemotherapy.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NP49HY
Utilization of Transoral Robotic Surgery (TORS) in patients with Oropharyngeal Squamous Cell Carcinoma and its impact on survival and use of chemotherapy
Publication date: November 2018
Source: Oral Oncology, Volume 86
Author(s): Sujith Baliga, Rafi Kabarriti, Julie Jiang, Vikas Mehta, Chandan Guha, Shalom Kalnicki, Richard V. Smith, Madhur K. Garg
Abstract
Objective
To determine whether patients with Oropharyngeal Squamous Cell Carcinoma (OPSCC) treated with Transoral Robotic Surgery (TORS) have similar survival to patients treated with definitive RT.
Materials and methods
Using the National Cancer Database (NCDB) registry, we identified patients with newly diagnosed clinical T1-T2, N0-N2b OPSCC between 2010 and 2014. A multivariable logistic regression was utilized to determine the association between chemotherapy use and primary treatment modality (TORS vs definitive RT). Kaplan Meier survival analysis was used to estimate overall survival. Propensity score matching was utilized to address selection bias.
Results
We identified 17,150 patients, of which 14,470 (84.4%) received primary RT and 2,680 (15.6%) underwent TORS. The median follow-up for the cohort was 31.4 months. Propensity score matching demonstrated similar 5-year OS for patients treated with either definitive RT or TORS (81% vs 84%, log rank p = 0.10). There was no difference in survival outcomes by treatment selection (TORS or definitive RT) in either HPV positive or HPV negative subtypes. Patients treated with TORS were less likely to receive chemotherapy compared to patients treated with definitive RT and this was also demonstrated in a propensity matched analysis (OR: 0.09, 95%CI 0.078–0.12, p < 0.001). Only 68.4% of TORS treated patients underwent adjuvant RT, compared to 100% of patients in the primary RT cohort (p < 0.001).
Conclusions and relevance
For patients with OPSCC, TORS results in similar OS outcomes and is associated with decreased chemotherapy and RT use compared to definitive RT. Our results demonstrate the feasibility of TORS in a select subgroup of OPSCC patients.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xnebWH
HPV status predicts for improved survival following chemotherapy in metastatic squamous cell carcinoma of the oropharynx
Publication date: November 2018
Source: Oral Oncology, Volume 86
Author(s): Luke R.G. Pike, William L. Hwang, Trevor J. Royce, Nina N. Sanford, Brandon A. Mahal
Abstract
Objective
We sought to further define prognostic and predictive value of human papillomavirus (HPV) status in metastatic squamous cell carcinoma of the oropharynx (OPC).
Materials and methods
A Surveillance, Epidemiology, and End Results custom database identified 5940 adult patients, >18-years-old, with primary SCCHN and known HPV status, diagnosed from 2013 to 2014. Wilcoxon rank-sum and Mantel-Haenszel χ2 tests compared distributions of continuous and categorical covariates. Fine-Gray competing risks regressions estimated hazard ratios by HPV status, and predictive analyses were performed including the interaction term HPV status × Receipt of Chemotherapy.
Results
182 of 5940 patients (4.0%) had metastatic OPC at diagnosis (106/3925 [2.7%] HPV+ and 76/1894 [4.0%] HPV−). HPV+ disease was prognostic for improved 20-month cancer-specific mortality (CSM) (47.1% vs 72.5%, HR 0.43, 95% CI 0.26–0.74, p = 0.002) on univariable analysis. HPV status was predictive of response to chemotherapy—adjusted HRs for receipt of chemotherapy were 0.11 (95% CI 0.03–0.37) and 0.34 (95% CI 0.18–0.64) for HPV+ versus HPV− disease, respectively (PHPV status∗Chemotherapy = 0.036).
Conclusion
HPV status has known prognostic value in locally advanced OPC, but data on metastatic OPC are sparse. In this work, we demonstrate that HPV status is strongly prognostic for CSM in metastatic OPC and show for the first time that HPV status predicts for response to chemotherapy.
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Whole-Body Magnetic Resonance Imaging in Rheumatic and Systemic Diseases: From Emerging to Validated Indications
Publication date: Available online 15 September 2018
Source: Magnetic Resonance Imaging Clinics of North America
Author(s): Elie Barakat, Thomas Kirchgesner, Perrine Triqueneaux, Christine Galant, Maria Stoenoiu, Frederic E. Lecouvet
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Quantitative Whole-Body Diffusion-Weighted MR Imaging
Publication date: Available online 15 September 2018
Source: Magnetic Resonance Imaging Clinics of North America
Author(s): Ricardo Donners, Matthew Blackledge, Nina Tunariu, Christina Messiou, Elmar M. Merkle, Dow-Mu Koh
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Whole-Body Magnetic Resonance Imaging in Rheumatic and Systemic Diseases: From Emerging to Validated Indications
Publication date: Available online 15 September 2018
Source: Magnetic Resonance Imaging Clinics of North America
Author(s): Elie Barakat, Thomas Kirchgesner, Perrine Triqueneaux, Christine Galant, Maria Stoenoiu, Frederic E. Lecouvet
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Quantitative Whole-Body Diffusion-Weighted MR Imaging
Publication date: Available online 15 September 2018
Source: Magnetic Resonance Imaging Clinics of North America
Author(s): Ricardo Donners, Matthew Blackledge, Nina Tunariu, Christina Messiou, Elmar M. Merkle, Dow-Mu Koh
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You’re Never Fully Dressed Without a Smile
Publication date: Available online 15 September 2018
Source: Otolaryngologic Clinics of North America
Author(s): Sujana S. Chandrasekhar
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Facial Palsy: Diagnostic and Therapeutic Management
Publication date: Available online 15 September 2018
Source: Otolaryngologic Clinics of North America
Author(s): Teresa M. O, Nate Jowett, Tessa Hadlock
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You’re Never Fully Dressed Without a Smile
Publication date: Available online 15 September 2018
Source: Otolaryngologic Clinics of North America
Author(s): Sujana S. Chandrasekhar
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Facial Palsy: Diagnostic and Therapeutic Management
Publication date: Available online 15 September 2018
Source: Otolaryngologic Clinics of North America
Author(s): Teresa M. O, Nate Jowett, Tessa Hadlock
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Structural and Functional Pulmonary Magnetic Resonance Imaging in Pediatrics—From the Neonate to the Young Adult
Publication date: Available online 15 September 2018
Source: Academic Radiology
Author(s): Laura L. Walkup, Nara S. Higano, Jason C. Woods
The clinical imaging modalities available to investigate pediatric pulmonary conditions such as bronchopulmonary dysplasia, cystic fibrosis, and asthma are limited primarily to chest x-ray radiograph and computed tomography. As the challenges that historically limited the application of magnetic resonance imaging (MRI) to the lung have been overcome, its clinical potential has greatly expanded. In this review article, recent advances in pulmonary MRI including ultrashort echo time and hyperpolarized-gas MRI techniques are discussed with an emphasis on pediatric research and translational applications.
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Describing the mandible in patients with craniofacial microsomia based on principal component analysis and thin plate spline video analysis
Publication date: Available online 15 September 2018
Source: International Journal of Oral and Maxillofacial Surgery
Author(s): O. Kaya, B.I. Pluijmers, F. Staal, C. Ruff, B.L. Padwa, M.J. Koudstaal, D.J. Dunaway
Abstract
Craniofacial microsomia (CFM) is most often described as a unilateral malformation of derivatives of the first and second branchial arches. The mandible has been classified using several classification systems. However, all are based on two-dimensional imaging. The aim of this study was to mathematically describe the deformed mandible based on principal component analysis (PCA) in a three-dimensional way. This may aid in defining the flaws in existing surgical corrections of the mandible through the identification of the differences in shape compared with a normal mandible in a holistic view with the help of videos. Forty-three homologous landmarks were defined to describe a mandible with CFM. Computed tomography scans of 22 patients and 30 controls were marked manually. The changes in shape between the mandibles were visualized using videos. A lateral rotation with increase in posterior rotation of the condyle due to shortening of the condyle–gonial height and a longitudinal rotation with outward bending of the mandibular angle were noted on the affected side, as well as an inward bending of the angle on the unaffected side. Due to the compensatory remodelling of the mandible on the unaffected side, one could suggest that CFM is never truly unilateral.
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Describing the mandible in patients with craniofacial microsomia based on principal component analysis and thin plate spline video analysis
Publication date: Available online 15 September 2018
Source: International Journal of Oral and Maxillofacial Surgery
Author(s): O. Kaya, B.I. Pluijmers, F. Staal, C. Ruff, B.L. Padwa, M.J. Koudstaal, D.J. Dunaway
Abstract
Craniofacial microsomia (CFM) is most often described as a unilateral malformation of derivatives of the first and second branchial arches. The mandible has been classified using several classification systems. However, all are based on two-dimensional imaging. The aim of this study was to mathematically describe the deformed mandible based on principal component analysis (PCA) in a three-dimensional way. This may aid in defining the flaws in existing surgical corrections of the mandible through the identification of the differences in shape compared with a normal mandible in a holistic view with the help of videos. Forty-three homologous landmarks were defined to describe a mandible with CFM. Computed tomography scans of 22 patients and 30 controls were marked manually. The changes in shape between the mandibles were visualized using videos. A lateral rotation with increase in posterior rotation of the condyle due to shortening of the condyle–gonial height and a longitudinal rotation with outward bending of the mandibular angle were noted on the affected side, as well as an inward bending of the angle on the unaffected side. Due to the compensatory remodelling of the mandible on the unaffected side, one could suggest that CFM is never truly unilateral.
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Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
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Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
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Frequency Offset Corrected Inversion Pulse for B0 and B1 Insensitive Fat Suppression at 3T: Application to MR Neurography of Brachial Plexus
Journal of Magnetic Resonance Imaging, EarlyView.
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Frequency Offset Corrected Inversion Pulse for B0 and B1 Insensitive Fat Suppression at 3T: Application to MR Neurography of Brachial Plexus
Journal of Magnetic Resonance Imaging, EarlyView.
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Bcl2L12 plays a critical role in the development of airway allergy via inducing aberrant T helper-2 polarization
Bcl2L12 plays an important role in the pathogenesis of allergic asthma by promoting the differentiation of Th2 cells, which may be a novel therapeutic target in the treatment of allergic asthma (Source: Journal of Allergy and Clinical Immunology)
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Bcl2L12 plays a critical role in the development of airway allergy via inducing aberrant T helper-2 polarization
Bcl2L12 plays an important role in the pathogenesis of allergic asthma by promoting the differentiation of Th2 cells, which may be a novel therapeutic target in the treatment of allergic asthma (Source: Journal of Allergy and Clinical Immunology)
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β-eudesmol inhibits thymic stromal lymphopoietin through blockade of caspase-1/NF-κB signal cascade in allergic rhinitis murine model.
Authors: Moon PD, Han NR, Lee JS, Kim HY, Hong S, Kim HJ, Yoo MS, Kim HM, Jeong HJ Abstract Allergic rhinitis (AR) is a global health problem because of its steadily increasing incidence and prevalence that currently affects about 30% of people worldwide. β-eudesmol has various beneficial effects, including anti-cancer and anti-allergic activities. However, the effects of β-eudesmol on AR have not yet been clarified; thus, we investigated the effects of β-eudesmol in an ovalbumin-induced AR animal model using enzyme-linked immunosorbent assay, histamine assay, Western blotting, and hematoxylin and eosin staining methods. β-eudesmol reduced the nasal rubs score and levels of histamine and immunoglobulin E in serum of AR mouse. In addition, the levels of thymic stromal lymphopoie...
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