Epidemiology of hallucinogen use in the U.S. results from the National epidemiologic survey on alcohol and related conditions III

Publication date: Available online 16 September 2018

Source: Addictive Behaviors

Author(s): Nadav Shalit, Jürgen Rehm, Shaul Lev-Ran

Abstract

Background

Population-based data regarding the epidemiology of hallucinogen use and co-occurring psychiatric disorders is largely absent from the literature. We aim to present findings on the prevalence, sociodemographic correlates, psychiatric comorbidity, treatment utilization, social support and associated disability of hallucinogen use using nationally representative data.

Method

We analyzed data from the National Epidemiologic Study on Alcohol and Related Conditions-III (2011–2012, N = 36,309). We conducted multivariate logistic regression analyses in unadjusted and adjusted models in order to explore the odds of psychiatric disorders and associated disability among hallucinogen users.

Results

Prevalence of twelve-month and lifetime hallucinogen use was 0.62% and 9.32%, respectively. Hallucinogen use was found to be significantly associated with mood disorders, anxiety disorders, eating disorders, personality disorders and substance use disorders. Following adjustment, significant associations were retained with several substance use disorders (adjusted odds ratio (AOR) for heroin use disorder = 4.89 (95% CI, 1.90–12.58), personality disorders (AOR = 2.10 (95% CI, 1.81–2.44)), Post-Traumatic Stress Disorder (AOR = 1.86, 95% CI 1.00–3.45) and past suicide attempts (AOR = 1.49, 95% CI 1.21–1.85).

Conclusions

Lifetime hallucinogen use in the US is prevalent and highly comorbid with other substance use and psychiatric disorders. Hallucinogen Use Disorder is relatively uncommon, with a low risk of development following exposure to hallucinogens. There are significant associations between hallucinogen use and substance use disorders, personality disorders, PTSD and past suicide attempts. The evolving therapeutic utility of this class of substances requires further assessment of short- and long-term risks of use, before large scale clinical application is pursued.

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Epidemiology of hallucinogen use in the U.S. results from the National epidemiologic survey on alcohol and related conditions III

Publication date: Available online 16 September 2018

Source: Addictive Behaviors

Author(s): Nadav Shalit, Jürgen Rehm, Shaul Lev-Ran

Abstract

Background

Population-based data regarding the epidemiology of hallucinogen use and co-occurring psychiatric disorders is largely absent from the literature. We aim to present findings on the prevalence, sociodemographic correlates, psychiatric comorbidity, treatment utilization, social support and associated disability of hallucinogen use using nationally representative data.

Method

We analyzed data from the National Epidemiologic Study on Alcohol and Related Conditions-III (2011–2012, N = 36,309). We conducted multivariate logistic regression analyses in unadjusted and adjusted models in order to explore the odds of psychiatric disorders and associated disability among hallucinogen users.

Results

Prevalence of twelve-month and lifetime hallucinogen use was 0.62% and 9.32%, respectively. Hallucinogen use was found to be significantly associated with mood disorders, anxiety disorders, eating disorders, personality disorders and substance use disorders. Following adjustment, significant associations were retained with several substance use disorders (adjusted odds ratio (AOR) for heroin use disorder = 4.89 (95% CI, 1.90–12.58), personality disorders (AOR = 2.10 (95% CI, 1.81–2.44)), Post-Traumatic Stress Disorder (AOR = 1.86, 95% CI 1.00–3.45) and past suicide attempts (AOR = 1.49, 95% CI 1.21–1.85).

Conclusions

Lifetime hallucinogen use in the US is prevalent and highly comorbid with other substance use and psychiatric disorders. Hallucinogen Use Disorder is relatively uncommon, with a low risk of development following exposure to hallucinogens. There are significant associations between hallucinogen use and substance use disorders, personality disorders, PTSD and past suicide attempts. The evolving therapeutic utility of this class of substances requires further assessment of short- and long-term risks of use, before large scale clinical application is pursued.

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Photoreduction of ferricytochrome c in the presence of potassium ferrocyanide

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00286J, Paper

Reinhard Schweitzer-Stenner, Dmitry Malyshka
Ferricytochrome c has been previously shown to photoreduce in the presence of ferrocyanide anions, but the process was poorly understood. Here, we propose a kinetic model for this phenomenon and...
The content of this RSS Feed (c) The Royal Society of Chemistry

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The Cationic Dye Basic Orange 21 (BO21) as a Potential Fluorescent Sensor

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C7PP00455A, Paper

Zehavit Eizig, Mark Alan Iron, Harvey Kasdan, Dan Amir, Elena Afrimzon, Naomi Zurgil, Sergei Moshkov, Mordechai Deutsch
The present study investigates the fluorescence properties of BO21 and their dependence on various intracellular conditions. Results obtained with cell-free solutions indicate that the influences of pH and temperature on...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Photoreduction of ferricytochrome c in the presence of potassium ferrocyanide

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00286J, Paper

Reinhard Schweitzer-Stenner, Dmitry Malyshka
Ferricytochrome c has been previously shown to photoreduce in the presence of ferrocyanide anions, but the process was poorly understood. Here, we propose a kinetic model for this phenomenon and...
The content of this RSS Feed (c) The Royal Society of Chemistry

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The Cationic Dye Basic Orange 21 (BO21) as a Potential Fluorescent Sensor

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C7PP00455A, Paper

Zehavit Eizig, Mark Alan Iron, Harvey Kasdan, Dan Amir, Elena Afrimzon, Naomi Zurgil, Sergei Moshkov, Mordechai Deutsch
The present study investigates the fluorescence properties of BO21 and their dependence on various intracellular conditions. Results obtained with cell-free solutions indicate that the influences of pH and temperature on...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Fall for apples

Fall for apples  Walker Pilot IndependentFull coverage

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Desmoid-type fibromatosis mimicking cystic retroperitoneal mass: case report and literature review

Abstract

Background

Retroperitoneal desmoid-type fibromatosis (DF) is an uncommon mesenchymal neoplasm presenting as a firm mass with locally aggressive features. It usually manifests as a well-circumscribed or ill-defined, solid mass on cross-sectional imaging. Cystic changes of DF have been described in the literature in association with prolonged medical treatment or abscess formation. However, spontaneous cystic change is rarely reported.

Case presentation

Here we report the case of a 46-year-old patient with a DF mimicked a large cystic tumor in the retroperitoneum. Ultrasonography and computed tomography were performed in order to search for localizations and characteristics of the cystic tumor. Radiological findings showed an oval cystic mass with a relatively thick wall, measuring 18.3 × 12.3 × 21.5 cm in the left upper abdomen. Laparoscopic spleen-preserving distal pancreatectomy was performed and histopathological examination by immunohistochemical study enabled us to diagnose a DF invading the pancreatic parenchyma. The patient remained asymptomatic during an 8-month follow up period.

Conclusions

We report an extremely rare case of retroperitoneal DF with spontaneous cystic change. DF can manifest as a mainly cystic mass with a thick wall, as in our case, which makes the correct diagnosis difficult. DF should be included in the preoperative differential diagnosis of a cystic retroperitoneal mass, regardless of its rarity.

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Fall for apples

Fall for apples  Walker Pilot IndependentFull coverage

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Desmoid-type fibromatosis mimicking cystic retroperitoneal mass: case report and literature review

Abstract

Background

Retroperitoneal desmoid-type fibromatosis (DF) is an uncommon mesenchymal neoplasm presenting as a firm mass with locally aggressive features. It usually manifests as a well-circumscribed or ill-defined, solid mass on cross-sectional imaging. Cystic changes of DF have been described in the literature in association with prolonged medical treatment or abscess formation. However, spontaneous cystic change is rarely reported.

Case presentation

Here we report the case of a 46-year-old patient with a DF mimicked a large cystic tumor in the retroperitoneum. Ultrasonography and computed tomography were performed in order to search for localizations and characteristics of the cystic tumor. Radiological findings showed an oval cystic mass with a relatively thick wall, measuring 18.3 × 12.3 × 21.5 cm in the left upper abdomen. Laparoscopic spleen-preserving distal pancreatectomy was performed and histopathological examination by immunohistochemical study enabled us to diagnose a DF invading the pancreatic parenchyma. The patient remained asymptomatic during an 8-month follow up period.

Conclusions

We report an extremely rare case of retroperitoneal DF with spontaneous cystic change. DF can manifest as a mainly cystic mass with a thick wall, as in our case, which makes the correct diagnosis difficult. DF should be included in the preoperative differential diagnosis of a cystic retroperitoneal mass, regardless of its rarity.

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Patients with out ‐of‐hospital cardiac arrest show decreased human leucocyte antigen‐DR expression on monocytes and B and T lymphocytes after return of spontaneous circulation

Scandinavian Journal of Immunology, EarlyView. (Source: Scandinavian Journal of Immunology)

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Contact Dermatitis in Atopic Dermatitis Children —Past, Present, and Future

AbstractAllergic contact dermatitis (ACD) used to be considered a rarity in children, but recently has been estimated to effect 4.4 million children in the USA alone, with a notable rise in investigative research in the field of pediatric ACD. Researchers have shown that patch testing is safe and effective in afflicted children and that those with atopic dermatitis (AD) have similar sensitization rates, although they have a higher sensitization to certain allergens, thought to be related to the inflammatory (IL-4) milieu. Patch testing assessment guidelines in children include five key considerations: if a patient 's dermatitis worsens, changes distribution, fails to improve with topical therapy, or immediately rebounds after removal of topical treatments; if a patient has a particular d...

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NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis

Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)

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Preliminary study on chronic granulomatous disease in Sri Lanka

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency of the phagocytic cells, which results in absent or diminished levels of microbicidal reactive oxygen species. The disease occurs due to g... (Source: Allergy, Asthma and Clinical Immunology)

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Associations of maternal immune response with MeHg exposure at 28 weeks’ gestation in the Seychelles Child Development Study

American Journal of Reproductive Immunology, EarlyView. (Source: American Journal of Reproductive Immunology)

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Non ‐atopic Rhinitis at Age 6 is Associated with Subsequent Development of Asthma

Clinical&Experimental Allergy,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Allergy)

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Patients with out ‐of‐hospital cardiac arrest show decreased human leucocyte antigen‐DR expression on monocytes and B and T lymphocytes after return of spontaneous circulation

Scandinavian Journal of Immunology, EarlyView. (Source: Scandinavian Journal of Immunology)

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Targeting the ICOS/ICOS ‐L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease

Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)

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Contact Dermatitis in Atopic Dermatitis Children —Past, Present, and Future

AbstractAllergic contact dermatitis (ACD) used to be considered a rarity in children, but recently has been estimated to effect 4.4 million children in the USA alone, with a notable rise in investigative research in the field of pediatric ACD. Researchers have shown that patch testing is safe and effective in afflicted children and that those with atopic dermatitis (AD) have similar sensitization rates, although they have a higher sensitization to certain allergens, thought to be related to the inflammatory (IL-4) milieu. Patch testing assessment guidelines in children include five key considerations: if a patient 's dermatitis worsens, changes distribution, fails to improve with topical therapy, or immediately rebounds after removal of topical treatments; if a patient has a particular d...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OvRVB6

NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis

Clinical&Experimental Immunology, EarlyView. (Source: Clinical and Experimental Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NONtR3

Preliminary study on chronic granulomatous disease in Sri Lanka

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency of the phagocytic cells, which results in absent or diminished levels of microbicidal reactive oxygen species. The disease occurs due to g... (Source: Allergy, Asthma and Clinical Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Associations of maternal immune response with MeHg exposure at 28 weeks’ gestation in the Seychelles Child Development Study

American Journal of Reproductive Immunology, EarlyView. (Source: American Journal of Reproductive Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOMVKZ

Non ‐atopic Rhinitis at Age 6 is Associated with Subsequent Development of Asthma

Clinical&Experimental Allergy,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Allergy)

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Targeting the ICOS/ICOS ‐L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease

Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)

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Human Connectome Project-style resting-state functional MRI at 7 Tesla using radiofrequency parallel transmission

Publication date: Available online 17 September 2018

Source: NeuroImage

Author(s): Xiaoping Wu, Edward J. Auerbach, An T. Vu, Steen Moeller, Pierre-François Van de Moortele, Essa Yacoub, Kâmil Uğurbil

Abstract

We investigate the utility of RF parallel transmission (pTx) for whole-brain resting-state functional MRI (rfMRI) acquisition at 7 Tesla (7T). To this end, Human Connectome Project (HCP)-style data acquisitions were chosen as a showcase example. Five healthy subjects were scanned in pTx and single-channel transmit (1Tx) modes. The pTx data were acquired using a prototype 16-channel transmit system and a commercially available Nova 8-channel transmit 32-channel receive RF head coil. Additionally, pTx single-spoke multiband (MB) pulses were designed to image sagittal slices. HCP-style 7T rfMRI data (1.6-mm isotropic resolution, 5-fold slice and 2-fold in-plane acceleration, 3600 vol and ∼ 1-h scan) were acquired with pTx and the results were compared to those acquired with the original 7T HCP rfMRI protocol. The use of pTx significantly improved flip-angle uniformity across the brain, with coefficient of variation (i.e., std/mean) of whole-brain flip-angle distribution reduced on average by ∼39%. This in turn yielded ∼17% increase in group temporal SNR (tSNR) as averaged across the entire brain and ∼10% increase in group functional contrast-to-noise ratio (fCNR) as averaged across the grayordinate space (including cortical surfaces and subcortical voxels). Furthermore, when placing a seed in either the posterior parietal lobe or putamen estimate seed-based dense connectome, the increase in fCNR was observed to translate into stronger correlation of the seed with the rest of the grayordinate space. We have demonstrated the utility of pTx for slice-accelerated high-resolution whole-brain rfMRI at 7T; as compared to current state-of-the-art, the use of pTx improves flip-angle uniformity, increases tSNR, enhances fCNR and strengthens functional connectivity estimation.

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The alteration landscape of the cerebral cortex

Publication date: Available online 17 September 2018

Source: NeuroImage

Author(s): Franco Cauda, Andrea Nani, Jordi Manuello, Donato Liloia, Karina Tatu, Ugo Vercelli, Sergio Duca, Peter T. Fox, Tommaso Costa

Abstract

Growing evidence is challenging the assumption that brain disorders are diagnostically clear-cut categories. Transdiagnostic studies show that a set of cerebral areas is frequently altered in a variety of psychiatric as well as neurological syndromes. In order to provide a map of the altered areas in the pathological brain we devised a metric, called alteration entropy (A-entropy), capable of denoting the "structural alteration variety" of an altered region. Using the whole voxel-based morphometry database of BrainMap, we were able to differentiate the brain areas exhibiting a high degree of overlap between different neuropathologies (or high value of A-entropy) from those exhibiting a low degree of overlap (or low value of A-entropy). The former, which are parts of large-scale brain networks with attentional, emotional, salience, and premotor functions, are thought to be more vulnerable to a great range of brain diseases; while the latter, which include the sensorimotor, visual, inferior temporal, and supramarginal regions, are thought to be more informative about the specific impact of brain diseases. Since low A-entropy areas appear to be altered by a smaller number of brain disorders, they are more informative than the areas characterized by high values of A-entropy. It is also noteworthy that even the areas showing low values of A-entropy are substantially altered by a variety of brain disorders. In fact, no cerebral area appears to be only altered by a specific disorder. Our study shows that the overlap of areas with high A-entropy provides support for a transdiagnostic approach to brain disorders but, at the same time, suggests that fruitful differences can be traced among brain diseases, as some areas can exhibit an alteration profile more specific to certain disorders than to others.

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Human Connectome Project-style resting-state functional MRI at 7 Tesla using radiofrequency parallel transmission

Publication date: Available online 17 September 2018

Source: NeuroImage

Author(s): Xiaoping Wu, Edward J. Auerbach, An T. Vu, Steen Moeller, Pierre-François Van de Moortele, Essa Yacoub, Kâmil Uğurbil

Abstract

We investigate the utility of RF parallel transmission (pTx) for whole-brain resting-state functional MRI (rfMRI) acquisition at 7 Tesla (7T). To this end, Human Connectome Project (HCP)-style data acquisitions were chosen as a showcase example. Five healthy subjects were scanned in pTx and single-channel transmit (1Tx) modes. The pTx data were acquired using a prototype 16-channel transmit system and a commercially available Nova 8-channel transmit 32-channel receive RF head coil. Additionally, pTx single-spoke multiband (MB) pulses were designed to image sagittal slices. HCP-style 7T rfMRI data (1.6-mm isotropic resolution, 5-fold slice and 2-fold in-plane acceleration, 3600 vol and ∼ 1-h scan) were acquired with pTx and the results were compared to those acquired with the original 7T HCP rfMRI protocol. The use of pTx significantly improved flip-angle uniformity across the brain, with coefficient of variation (i.e., std/mean) of whole-brain flip-angle distribution reduced on average by ∼39%. This in turn yielded ∼17% increase in group temporal SNR (tSNR) as averaged across the entire brain and ∼10% increase in group functional contrast-to-noise ratio (fCNR) as averaged across the grayordinate space (including cortical surfaces and subcortical voxels). Furthermore, when placing a seed in either the posterior parietal lobe or putamen estimate seed-based dense connectome, the increase in fCNR was observed to translate into stronger correlation of the seed with the rest of the grayordinate space. We have demonstrated the utility of pTx for slice-accelerated high-resolution whole-brain rfMRI at 7T; as compared to current state-of-the-art, the use of pTx improves flip-angle uniformity, increases tSNR, enhances fCNR and strengthens functional connectivity estimation.

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The alteration landscape of the cerebral cortex

Publication date: Available online 17 September 2018

Source: NeuroImage

Author(s): Franco Cauda, Andrea Nani, Jordi Manuello, Donato Liloia, Karina Tatu, Ugo Vercelli, Sergio Duca, Peter T. Fox, Tommaso Costa

Abstract

Growing evidence is challenging the assumption that brain disorders are diagnostically clear-cut categories. Transdiagnostic studies show that a set of cerebral areas is frequently altered in a variety of psychiatric as well as neurological syndromes. In order to provide a map of the altered areas in the pathological brain we devised a metric, called alteration entropy (A-entropy), capable of denoting the "structural alteration variety" of an altered region. Using the whole voxel-based morphometry database of BrainMap, we were able to differentiate the brain areas exhibiting a high degree of overlap between different neuropathologies (or high value of A-entropy) from those exhibiting a low degree of overlap (or low value of A-entropy). The former, which are parts of large-scale brain networks with attentional, emotional, salience, and premotor functions, are thought to be more vulnerable to a great range of brain diseases; while the latter, which include the sensorimotor, visual, inferior temporal, and supramarginal regions, are thought to be more informative about the specific impact of brain diseases. Since low A-entropy areas appear to be altered by a smaller number of brain disorders, they are more informative than the areas characterized by high values of A-entropy. It is also noteworthy that even the areas showing low values of A-entropy are substantially altered by a variety of brain disorders. In fact, no cerebral area appears to be only altered by a specific disorder. Our study shows that the overlap of areas with high A-entropy provides support for a transdiagnostic approach to brain disorders but, at the same time, suggests that fruitful differences can be traced among brain diseases, as some areas can exhibit an alteration profile more specific to certain disorders than to others.

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Interpace Diagnostics Supports Research Efforts of Pancreatic and Thyroid Cancer Patient Advocacy Groups

Interpace Diagnostics Supports Research Efforts of Pancreatic and Thyroid Cancer Patient Advocacy Groups  NasdaqFull coverage

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Interpace Diagnostics Supports Research Efforts of Pancreatic and Thyroid Cancer Patient Advocacy Groups

Interpace Diagnostics Supports Research Efforts of Pancreatic and Thyroid Cancer Patient Advocacy Groups  NasdaqFull coverage

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Validation and comparison of the Arabic versions of GOHAI and OHIP-14 in patients with and without denture experience

Abstract

Background

The assessment of oral heath related quality of life (OHRQoL) for complete denture wearers according to a participant's subjective perception may provide an indication of the adaptive capacity of the individual. The aim of this study was to compare and assess the validation of two quality of life measures, the Oral Health Impact Profile-14 (OHIP-14) and Geriatric Oral Health Assessment Index (GOHAI), in patients with and without previous denture experience.

Methods

A total of 69 elders (36 male and 34 female; mean age, 63 years) from Dental Clinics of the University of Khartoum and the National University in Sudan, with and without previous denture experience, were included in the study. OHRQoL was assessed using two Arabic-translated questionnaires (OHIP-14 and GOHAI) before and after complete denture therapy. Global self-ratings of oral and general health were obtained, and denture satisfaction was assessed using the Denture Satisfaction questionnaire.

Results

Both tools had significant correlations with self-rating oral health in patients without denture experience (P < 0.05). However, no significant correlations were found in patients with denture experience. There were significant differences between pre-and post-treatment total scores with both the GOHAI and OHIP-14 (P < 0.001). Responsiveness to treatment using GOHAI and OHIP-14 revealed overall mean effect size higher in patients without (1.49) and (0.83) than those with previous denture experience (0.89) and (0.60), respectively. However, neither tool could detect significant differences between patients with and without denture experience (P > 0.05).

Conclusion

Greater improvements of OHRQoL after complete denture therapy were observed in participants without than those with previous denture experience. The Arabic-translated versions of GOHAI and OHIP-14 can be regarded as effective measures for assessing treatment outcomes of complete denture therapy.

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A prospective multicenter evaluation of immediately functionalized tapered conical connection implants for single restorations in maxillary anterior and premolar sites: 3-year results

Abstract

Objectives

This multicenter prospective clinical trial investigated immediately provisionalized, anodized, conical connection, tapered implants with platform shifting in maxillary anterior and premolar sites.

Materials and methods

Patients requiring single-tooth implant-supported restorations in maxillary anterior and premolar sites were enrolled. Implants were immediately provisionalized and evaluated at insertion, 6 months, and annually thereafter. Outcome measures were marginal bone level change (ΔMBL), cumulative survival rate (CSR), and success rate, soft-tissue parameters, and oral health impact profile (OHIP). ΔMBL and Pink Esthetic Score were analyzed using Wilcoxon signed-rank tests. CSR was calculated using life table analysis. Other soft-tissue parameters were analyzed using sign tests.

Results

Of 94 enrolled patients (99 implants), 84 (88 implants) attended the 3-year follow-up. After an initial bone loss between implant insertion and 6 months (− 0.92 ± 1.23 mm), bone levels stabilized from 6 months to 3 years (0.13 ± 0.94 mm) with no significant change. The 3-year CSR was 98.9%, and the cumulative success rate was 96.9%. Papilla index scores of 2 or 3 were observed at 88.6% of sites at the 3-year visit compared with 32.8% at implant insertion. Improvements were observed for all other outcomes, including bleeding on probing, esthetics, plaque, and OHIP.

Conclusions

This restorative protocol was associated with high primary stability, patient satisfaction, stable bone levels, and an overall improvement of the soft tissue outcomes over a 3-year period.

Clinical relevance

The presented treatment is a viable option for single-tooth restorations of maxillary anterior teeth and premolars with successful short- to mid-long-term clinical outcomes.

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Validation and comparison of the Arabic versions of GOHAI and OHIP-14 in patients with and without denture experience

Abstract

Background

The assessment of oral heath related quality of life (OHRQoL) for complete denture wearers according to a participant's subjective perception may provide an indication of the adaptive capacity of the individual. The aim of this study was to compare and assess the validation of two quality of life measures, the Oral Health Impact Profile-14 (OHIP-14) and Geriatric Oral Health Assessment Index (GOHAI), in patients with and without previous denture experience.

Methods

A total of 69 elders (36 male and 34 female; mean age, 63 years) from Dental Clinics of the University of Khartoum and the National University in Sudan, with and without previous denture experience, were included in the study. OHRQoL was assessed using two Arabic-translated questionnaires (OHIP-14 and GOHAI) before and after complete denture therapy. Global self-ratings of oral and general health were obtained, and denture satisfaction was assessed using the Denture Satisfaction questionnaire.

Results

Both tools had significant correlations with self-rating oral health in patients without denture experience (P < 0.05). However, no significant correlations were found in patients with denture experience. There were significant differences between pre-and post-treatment total scores with both the GOHAI and OHIP-14 (P < 0.001). Responsiveness to treatment using GOHAI and OHIP-14 revealed overall mean effect size higher in patients without (1.49) and (0.83) than those with previous denture experience (0.89) and (0.60), respectively. However, neither tool could detect significant differences between patients with and without denture experience (P > 0.05).

Conclusion

Greater improvements of OHRQoL after complete denture therapy were observed in participants without than those with previous denture experience. The Arabic-translated versions of GOHAI and OHIP-14 can be regarded as effective measures for assessing treatment outcomes of complete denture therapy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MGy7Jx

A prospective multicenter evaluation of immediately functionalized tapered conical connection implants for single restorations in maxillary anterior and premolar sites: 3-year results

Abstract

Objectives

This multicenter prospective clinical trial investigated immediately provisionalized, anodized, conical connection, tapered implants with platform shifting in maxillary anterior and premolar sites.

Materials and methods

Patients requiring single-tooth implant-supported restorations in maxillary anterior and premolar sites were enrolled. Implants were immediately provisionalized and evaluated at insertion, 6 months, and annually thereafter. Outcome measures were marginal bone level change (ΔMBL), cumulative survival rate (CSR), and success rate, soft-tissue parameters, and oral health impact profile (OHIP). ΔMBL and Pink Esthetic Score were analyzed using Wilcoxon signed-rank tests. CSR was calculated using life table analysis. Other soft-tissue parameters were analyzed using sign tests.

Results

Of 94 enrolled patients (99 implants), 84 (88 implants) attended the 3-year follow-up. After an initial bone loss between implant insertion and 6 months (− 0.92 ± 1.23 mm), bone levels stabilized from 6 months to 3 years (0.13 ± 0.94 mm) with no significant change. The 3-year CSR was 98.9%, and the cumulative success rate was 96.9%. Papilla index scores of 2 or 3 were observed at 88.6% of sites at the 3-year visit compared with 32.8% at implant insertion. Improvements were observed for all other outcomes, including bleeding on probing, esthetics, plaque, and OHIP.

Conclusions

This restorative protocol was associated with high primary stability, patient satisfaction, stable bone levels, and an overall improvement of the soft tissue outcomes over a 3-year period.

Clinical relevance

The presented treatment is a viable option for single-tooth restorations of maxillary anterior teeth and premolars with successful short- to mid-long-term clinical outcomes.

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Central Nervous System Tuberculosis

Abstract

Purpose

As a result of multilateral migration and globalization in times of humanitarian crises, western countries face a possible increase in the incidence of central nervous system tuberculosis (CNS TB). The diagnosis of CNS TB is challenging and often delayed due to the manifold and often non-specific presentation of the disease. The aim of this review is to analyze and summarize imaging features and correlated clinical findings of CNS TB.

Methods

The different manifestations of CNS TB are explained and illustrated by characteristic neuroradiological as well as neuropathological findings. An overview on diagnostic and therapeutic approaches is provided. For clarity, tables summarizing the lesion patterns, differential diagnoses and diagnostic hints are added.

Results

The CNS TB can be manifested (1) diffuse as tuberculous meningitis (TBM), (2) localized as tuberculoma or (3) tuberculous abscess or (4) in extradural and intradural spinal infections. Information on clinical presentation, underlying pathology and the distinguishing features is demonstrated. The TBM is further described, which may lead to cranial nerve palsy, hydrocephalus and infarction due to associated arteritis of the basal perforators. The differential diagnoses are vast and include other infections, such as bacterial, viral or fungal meningoencephalitis, malignant causes or systemic inflammation with CNS. Complicating factors of diagnosis and treatment are HIV coinfection, multi-drug resistance and TB-associated immune reconstitution inflammatory syndrome (IRIS).

Conclusions

Neurologists and (neuro-)radiologists should be familiar with the neuroradiological presentation and the clinical course of CNS TB to ensure timely diagnosis and treatment.

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Central Nervous System Tuberculosis

Abstract

Purpose

As a result of multilateral migration and globalization in times of humanitarian crises, western countries face a possible increase in the incidence of central nervous system tuberculosis (CNS TB). The diagnosis of CNS TB is challenging and often delayed due to the manifold and often non-specific presentation of the disease. The aim of this review is to analyze and summarize imaging features and correlated clinical findings of CNS TB.

Methods

The different manifestations of CNS TB are explained and illustrated by characteristic neuroradiological as well as neuropathological findings. An overview on diagnostic and therapeutic approaches is provided. For clarity, tables summarizing the lesion patterns, differential diagnoses and diagnostic hints are added.

Results

The CNS TB can be manifested (1) diffuse as tuberculous meningitis (TBM), (2) localized as tuberculoma or (3) tuberculous abscess or (4) in extradural and intradural spinal infections. Information on clinical presentation, underlying pathology and the distinguishing features is demonstrated. The TBM is further described, which may lead to cranial nerve palsy, hydrocephalus and infarction due to associated arteritis of the basal perforators. The differential diagnoses are vast and include other infections, such as bacterial, viral or fungal meningoencephalitis, malignant causes or systemic inflammation with CNS. Complicating factors of diagnosis and treatment are HIV coinfection, multi-drug resistance and TB-associated immune reconstitution inflammatory syndrome (IRIS).

Conclusions

Neurologists and (neuro-)radiologists should be familiar with the neuroradiological presentation and the clinical course of CNS TB to ensure timely diagnosis and treatment.

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FIERCE for a cure: Natick boot camp raises money for cancer research

FIERCE for a cure: Natick boot camp raises money for cancer research  Wicked Local CambridgeFull coverage

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Differentiated Thyroid Cancer Therapeutics Market Report 2016 By Industry Size, Share & Key Drivers 2022

Differentiated Thyroid Cancer Therapeutics Market Report 2016 By Industry Size, Share & Key Drivers 2022  Tactical BusinessFull coverage

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UN seeks to open air bridge to aid Yemeni cancer patients

UN seeks to open air bridge to aid Yemeni cancer patients  gulfnews.comUN-Houthi deal on medical air bridge angers Yemen government  The NationalFull coverage

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FIERCE for a cure: Natick boot camp raises money for cancer research

FIERCE for a cure: Natick boot camp raises money for cancer research  Wicked Local CambridgeFull coverage

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Differentiated Thyroid Cancer Therapeutics Market Report 2016 By Industry Size, Share & Key Drivers 2022

Differentiated Thyroid Cancer Therapeutics Market Report 2016 By Industry Size, Share & Key Drivers 2022  Tactical BusinessFull coverage

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UN seeks to open air bridge to aid Yemeni cancer patients

UN seeks to open air bridge to aid Yemeni cancer patients  gulfnews.comUN-Houthi deal on medical air bridge angers Yemen government  The NationalFull coverage

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Editorial Board

Publication date: October 2018

Source: Journal of Environmental Radioactivity, Volumes 193–194

Author(s):

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Editorial Board

Publication date: October 2018

Source: Journal of Environmental Radioactivity, Volumes 193–194

Author(s):

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The European Head and Neck Cancer Community Comes Together to Make Sense of This Rare Form of Cancer

The European Head and Neck Cancer Community Comes Together to Make Sense of This Rare Form of Cancer  PR Newswire (press release)No more out of county travel for head and neck cancer patients  The Wiltshire Gazette and HeraldHead and Neck Cancer Treatment Market: Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2017  Our Market ResearchFull coverage

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Fairview School Foundation to honor surgeon and entrepreneur

Fairview School Foundation to honor surgeon and entrepreneur  GoErie.comFull coverage

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Nigerian Federal Ministry of Health to Launch Pilot Cancer Drug Access Program with BIO Ventures for Global Health

Nigerian Federal Ministry of Health to Launch Pilot Cancer Drug Access Program with BIO Ventures for Global Health  Tullahoma News and GuardianFull coverage

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The European Head and Neck Cancer Community Comes Together to Make Sense of This Rare Form of Cancer

The European Head and Neck Cancer Community Comes Together to Make Sense of This Rare Form of Cancer  PR Newswire (press release)No more out of county travel for head and neck cancer patients  The Wiltshire Gazette and HeraldHead and Neck Cancer Treatment Market: Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2017  Our Market ResearchFull coverage

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Fairview School Foundation to honor surgeon and entrepreneur

Fairview School Foundation to honor surgeon and entrepreneur  GoErie.comFull coverage

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Nigerian Federal Ministry of Health to Launch Pilot Cancer Drug Access Program with BIO Ventures for Global Health

Nigerian Federal Ministry of Health to Launch Pilot Cancer Drug Access Program with BIO Ventures for Global Health  Tullahoma News and GuardianFull coverage

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Contact Dermatitis in Atopic Dermatitis Children—Past, Present, and Future

Abstract

Allergic contact dermatitis (ACD) used to be considered a rarity in children, but recently has been estimated to effect 4.4 million children in the USA alone, with a notable rise in investigative research in the field of pediatric ACD. Researchers have shown that patch testing is safe and effective in afflicted children and that those with atopic dermatitis (AD) have similar sensitization rates, although they have a higher sensitization to certain allergens, thought to be related to the inflammatory (IL-4) milieu. Patch testing assessment guidelines in children include five key considerations: if a patient's dermatitis worsens, changes distribution, fails to improve with topical therapy, or immediately rebounds after removal of topical treatments; if a patient has a particular distribution of dermatitis; if a working patient has hand eczema that fails to improve with therapy; if the patient has AD that started in adolescence or adulthood with definitely no history of childhood eczema; and importantly, if a patient has severe or widespread atopic dermatitis that will require immunosuppressive systemic medication.

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Contact Dermatitis in Atopic Dermatitis Children—Past, Present, and Future

Abstract

Allergic contact dermatitis (ACD) used to be considered a rarity in children, but recently has been estimated to effect 4.4 million children in the USA alone, with a notable rise in investigative research in the field of pediatric ACD. Researchers have shown that patch testing is safe and effective in afflicted children and that those with atopic dermatitis (AD) have similar sensitization rates, although they have a higher sensitization to certain allergens, thought to be related to the inflammatory (IL-4) milieu. Patch testing assessment guidelines in children include five key considerations: if a patient's dermatitis worsens, changes distribution, fails to improve with topical therapy, or immediately rebounds after removal of topical treatments; if a patient has a particular distribution of dermatitis; if a working patient has hand eczema that fails to improve with therapy; if the patient has AD that started in adolescence or adulthood with definitely no history of childhood eczema; and importantly, if a patient has severe or widespread atopic dermatitis that will require immunosuppressive systemic medication.

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Progenics Announces Addition of AZEDRA® (iobenguane I 131) to National Comprehensive Cancer Network ...

Progenics Announces Addition of AZEDRA® (iobenguane I 131) to National Comprehensive Cancer Network ...  NasdaqFull coverage

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UN seeks to open air bridge to aid Yemeni cancer patients

UN seeks to open air bridge to aid Yemeni cancer patients  gulfnews.comHumanitarian Medical Air Bridge in Yemen [EN/AR]  ReliefWebFull coverage

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FIERCE for a cure: Natick boot camp raises money for cancer research

FIERCE for a cure: Natick boot camp raises money for cancer research  Wicked Local East BridgewaterFull coverage

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Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...

Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...  TokeNexaAnaplastic Thyroid Cancer Drug Market, Overview, Market Definition, Market Development Forecast 2018-2023  Trade Market ResearchFollicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025  Redfield Herald (press release) (blog)Full coverage

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Progenics Announces Addition of AZEDRA® (iobenguane I 131) to National Comprehensive Cancer Network ...

Progenics Announces Addition of AZEDRA® (iobenguane I 131) to National Comprehensive Cancer Network ...  NasdaqFull coverage

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UN seeks to open air bridge to aid Yemeni cancer patients

UN seeks to open air bridge to aid Yemeni cancer patients  gulfnews.comHumanitarian Medical Air Bridge in Yemen [EN/AR]  ReliefWebFull coverage

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Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...

Anaplastic Thyroid Cancer Drug | Global Market Detailed Analysis till 2023 | (Daiichi Sankyo Company, Limited ...  TokeNexaAnaplastic Thyroid Cancer Drug Market, Overview, Market Definition, Market Development Forecast 2018-2023  Trade Market ResearchFollicular Thyroid Cancer Drug Market Capacity, Production, Revenue, Price, Cost, Gross Margin Analysis 2018-2025  Redfield Herald (press release) (blog)Full coverage

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Contact Dermatitis in Atopic Dermatitis Children—Past, Present, and Future

Abstract

Allergic contact dermatitis (ACD) used to be considered a rarity in children, but recently has been estimated to effect 4.4 million children in the USA alone, with a notable rise in investigative research in the field of pediatric ACD. Researchers have shown that patch testing is safe and effective in afflicted children and that those with atopic dermatitis (AD) have similar sensitization rates, although they have a higher sensitization to certain allergens, thought to be related to the inflammatory (IL-4) milieu. Patch testing assessment guidelines in children include five key considerations: if a patient's dermatitis worsens, changes distribution, fails to improve with topical therapy, or immediately rebounds after removal of topical treatments; if a patient has a particular distribution of dermatitis; if a working patient has hand eczema that fails to improve with therapy; if the patient has AD that started in adolescence or adulthood with definitely no history of childhood eczema; and importantly, if a patient has severe or widespread atopic dermatitis that will require immunosuppressive systemic medication.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xqJcc3

Contact Dermatitis in Atopic Dermatitis Children—Past, Present, and Future

Abstract

Allergic contact dermatitis (ACD) used to be considered a rarity in children, but recently has been estimated to effect 4.4 million children in the USA alone, with a notable rise in investigative research in the field of pediatric ACD. Researchers have shown that patch testing is safe and effective in afflicted children and that those with atopic dermatitis (AD) have similar sensitization rates, although they have a higher sensitization to certain allergens, thought to be related to the inflammatory (IL-4) milieu. Patch testing assessment guidelines in children include five key considerations: if a patient's dermatitis worsens, changes distribution, fails to improve with topical therapy, or immediately rebounds after removal of topical treatments; if a patient has a particular distribution of dermatitis; if a working patient has hand eczema that fails to improve with therapy; if the patient has AD that started in adolescence or adulthood with definitely no history of childhood eczema; and importantly, if a patient has severe or widespread atopic dermatitis that will require immunosuppressive systemic medication.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xqJcc3

The European Head and Neck Cancer Community Comes Together to Make Sense of This Rare Form of Cancer

The European Head and Neck Cancer Community Comes Together to Make Sense of This Rare Form of Cancer  Markets InsiderNo more out of county travel for head and neck cancer patients  The Wiltshire Gazette and HeraldHead and Neck Cancer Treatment Market: Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2017  Our Market ResearchFull coverage

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The European Head and Neck Cancer Community Comes Together to Make Sense of This Rare Form of Cancer

The European Head and Neck Cancer Community Comes Together to Make Sense of This Rare Form of Cancer  Markets InsiderNo more out of county travel for head and neck cancer patients  The Wiltshire Gazette and HeraldHead and Neck Cancer Treatment Market: Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2017  Our Market ResearchFull coverage

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Non‐atopic Rhinitis at Age 6 is Associated with Subsequent Development of Asthma

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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Non‐atopic Rhinitis at Age 6 is Associated with Subsequent Development of Asthma

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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Immunostimulatory activity of low-molecular-weight hyaluronan on dendritic cells stimulated with Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis

Abstract

Objectives

Periodontitis is a chronic inflammatory disease characterized by tooth-supporting tissue destruction, which is elicited by the host's immune response triggered against periodonto-pathogen bacteria. During periodontal tissue destruction, extracellular matrix components are metabolized and fragmented. Some extracellular matrix component-derived fragments, such as low-molecular-weight hyaluronan (LMW-HA), have potent immunogenic potential, playing a role as damage-associated molecular patterns (DAMPs) during activation of immune cells. Dendritic cells (DCs) play a central role in the host's immune response displayed during periodontitis; thus, this study aimed to analyze whether LMW-HA has an immunostimulatory activity on DCs when stimulated with periodonto-pathogen bacteria.

Materials and methods

LMW-HA-treated and non-treated DCs were stimulated with Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis and the mRNA expression for cytokines tumor necrosis factor-α (TNF-alpha), interleukin-1β (IL-1B), interleukin-6 (IL-6), and interleukin-23 (IL-23A) was quantified by RT-qPCR. In addition, transcription factors interferon regulatory factor 4 (IRF4), interferon regulatory factor 8 (IRF8), neurogenic locus notch homolog protein 2 (NOTCH2), and basic leucine zipper ATF-like transcription factor 3 (BATF3), involved in DC activation, were analyzed.

Results

Higher expression levels of TNF-alpha, IL-1B, IL-6, and IL-23A were detected in LMW-HA-treated DCs after bacterial infection, as compared with non-treated DCs. When LMW-HA-treated DCs were infected with A. actinomycetemcomitans, higher levels of IRF4, NOTCH2, and BATF3 were detected compared with non-treated cells; whereas against P. gingivalis infection, increased levels of IRF4 and NOTCH2 were detected.

Conclusion

LMW-HA plays an immunostimulatory role on the immune response triggered by DCs during infection with A. actinomycetemcomitans or P. gingivalis.

Clinical relevance

Detection of extracellular matrix component-derived fragments produced during periodontal tissue destruction, such as LMW-HA, could explain at least partly unsuccessful periodontal treatment and the chronicity of the disease.

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Complication of AQUAfilling ® Gel Injection for Breast Augmentation: Case Report of One Case and Review of Literature

Abstract

Introduction

Augmentation mammoplasty is one of the most popular aesthetic operations in the world. In Korea, one of the fillers used for breast augmentation is AQUAfilling^® gel (Biomedica. spol, s,r,o, Czech Republic). AQUAfilling^® gel is a hydrophilic gel composed of 98% sodium chloride solution (0.9%) and 2% cation copolyamide.

Methods

This is a case report describing a patient that suffered complications after AQUAfilling^® gel injection for breast augmentation.

Results

A 32-year-old female patient was referred to our plastic surgery department with a chief complaint of repeated wound dehiscence and fluid discharge involving both breasts. She was treated via surgical intervention for removal of necrotic infected tissue and filler, as well as massive irrigation three times. After the third surgery, there were no complications, including infection or dehiscence, during a 1-year follow-up period.

Conclusions

Although AQUAfilling^® gel is easy to inject and is natural looking, once a complication occurs, treatment is difficult. Also, there are concerns regarding toxicity of the gel material and its influence on surrounding tissues. Hence, sufficient evidences of long-term safety must be accumulated and proved, until which time the aesthetic use of the unapproved filler must be restricted.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Experience of Immediate Ambulation and Early Discharge After Tumescent Anesthesia and Propofol Infusion in Cosmetic Breast Augmentation

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Patient-Reported Satisfaction Following Post-bariatric Surgery: A Systematic Review

Abstract

Introduction

The aims of our study were to identify studies that evaluated patient satisfaction following post-bariatric surgery, analyse existing questionnaires, and summarise their development, psychometric properties, and content.

Patients and Methods

A multistep search was undertaken on the web-based PubMed database from the National Library of Medicine to identify studies on patient satisfaction and quality of life following post-bariatric surgery. The authors summarised all the questionnaires used in every study and categorised them as generic, surgery specific, or ad hoc, and whether they contained either validated or unvalidated measures.

Results

Our search generated a total of 1754 articles. We performed a systematic review of the 12 remaining studies, because these had sufficient data and met the inclusion criteria. All the studies identified from the literature review were assessed to determine the type of surgery used, and whether or not the questionnaire used to analyse patient satisfaction had been validated. The questionnaires were analysed by reviewers to assess adherence to the rules of the US Food and Drug Administration and the Scientific Advisory Committee of the Medical Outcomes Trust. We identified 20 individual questionnaires that included 10 generic instruments that assessed quality of life, six instruments specific for post-bariatric surgery, three instruments specific for breast surgery.

Conclusions

In post-bariatric patients, the BODY-Q was shown to be a more objective and confident measure for evaluating the quality of life of patients following post-bariatric surgery.

Level of Evidence III

For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Is Latin America Ready to Identify Anaplastic Large Cell Lymphoma in Breast Implants Patients? Regional Encounter During the National Plastic Surgery Meeting in Cancun, Mexico

Abstract

Introduction

Anaplastic large cell lymphoma associated with breast implants is receiving increased attention. Most cases have been reported in Europe, North America (USA and Canada), Australia and New Zealand. Fewer cases have been reported in Latin America (including Mexico), Africa and Asia.

Methods

This report was delivered during our national plastic surgery meeting in Cancun in May 2017. Before the meeting, two participants reviewed the literature. The review was performed using the following information sources: PubMed, Embase, Cochrane, Fisterra, Google Scholar and LILACS, with entries from 1980 to August 2015 in several languages (English, Spanish, French and Portuguese). The results were revealed during the meeting to the other participants. The consensus was divided into two parts. The first part included an open-ended question regarding the incidence and prevalence of the problem. The second part included clinical scenarios with different items that were rated by the participants. After this activity, accordance among the responses was evaluated.

Results

Seven cases were reported during the meeting (3 from Mexico, 3 from Chile and 1 from Argentina). Fifty percent of the participants reported consulting with guidelines and clinical centers to help with potential cases. Most agreed that further studies must be done in cases of chronic seroma where the capsule plays an important role.

Discussion

A current debate exists about the incidence of this problem in Latin America because we did not report the same number of cases as Europe, Australia or North America. More studies are required to determine the differences among reports in Latin America.

Conclusion

Most representatives agreed that further studies must be done. Concern is increasing, and the problem is known. Other factors involved may be considered, and the problem must not be ignored.

No Level Assigned

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Complication of AQUAfilling ® Gel Injection for Breast Augmentation: Case Report of One Case and Review of Literature

Abstract

Introduction

Augmentation mammoplasty is one of the most popular aesthetic operations in the world. In Korea, one of the fillers used for breast augmentation is AQUAfilling^® gel (Biomedica. spol, s,r,o, Czech Republic). AQUAfilling^® gel is a hydrophilic gel composed of 98% sodium chloride solution (0.9%) and 2% cation copolyamide.

Methods

This is a case report describing a patient that suffered complications after AQUAfilling^® gel injection for breast augmentation.

Results

A 32-year-old female patient was referred to our plastic surgery department with a chief complaint of repeated wound dehiscence and fluid discharge involving both breasts. She was treated via surgical intervention for removal of necrotic infected tissue and filler, as well as massive irrigation three times. After the third surgery, there were no complications, including infection or dehiscence, during a 1-year follow-up period.

Conclusions

Although AQUAfilling^® gel is easy to inject and is natural looking, once a complication occurs, treatment is difficult. Also, there are concerns regarding toxicity of the gel material and its influence on surrounding tissues. Hence, sufficient evidences of long-term safety must be accumulated and proved, until which time the aesthetic use of the unapproved filler must be restricted.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Commentary on: Medial Osteoectomy as a Routine Procedure in Rhinoplasty: Six-Year Experience with an Innovative Technique

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Experience of Immediate Ambulation and Early Discharge After Tumescent Anesthesia and Propofol Infusion in Cosmetic Breast Augmentation

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Brazilian Consensus Recommendation on the Use of Polymethylmethacrylate Filler in Facial and Corporal Aesthetics

Abstract

Background

Considering that aesthetic benefits can be obtained with the use of permanent filling materials, this work focuses on the development of a consensus regarding the facial and corporal use of polymethylmethacrylate (PMMA) filler in Brazil.

Methods

A questionnaire regarding PMMA treatment, which included items on the main indication, application site, volume of product applied, criteria for selection of the material, complications, contraindications, and individual professional experience, was distributed to the Expert Group members. In addition, the responses were summarized, constituting the starting point for the debate regarding the use of PMMA-based fillers on The First Brazilian PMMA Symposium to create a guideline to be followed in PMMA facial and corporal treatments.

Results

This survey involved 87,371 cases. PMMA treatment is recommended for restorative and aesthetic purposes in facial and corporal cases, particularly for facial balance. PMMA 30% filler is recommended in specific facial sites (nose, mentum, mandible angle, zygomatic arc, and malar). PMMA filler is contraindicated in other sites (lips) regardless of concentration. With regard to facial treatment, the juxtaperiostal is the application plane most recommended. For PMMA corporal application, intramuscular is the application plane most indicated, while intradermal and justadermal planes are contraindicated. The submuscular plane application is relative to PMMA filler concentration. The experts also inquired regarding the amount of PMMA recommended in each corporal site (50 mL in the calf, 100–150 mL in the gluteal region).

Conclusion

These recommendations provide a guideline for physicians, supporting them to perform safe and efficacious treatment with PMMA fillers.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Patient-Reported Satisfaction Following Post-bariatric Surgery: A Systematic Review

Abstract

Introduction

The aims of our study were to identify studies that evaluated patient satisfaction following post-bariatric surgery, analyse existing questionnaires, and summarise their development, psychometric properties, and content.

Patients and Methods

A multistep search was undertaken on the web-based PubMed database from the National Library of Medicine to identify studies on patient satisfaction and quality of life following post-bariatric surgery. The authors summarised all the questionnaires used in every study and categorised them as generic, surgery specific, or ad hoc, and whether they contained either validated or unvalidated measures.

Results

Our search generated a total of 1754 articles. We performed a systematic review of the 12 remaining studies, because these had sufficient data and met the inclusion criteria. All the studies identified from the literature review were assessed to determine the type of surgery used, and whether or not the questionnaire used to analyse patient satisfaction had been validated. The questionnaires were analysed by reviewers to assess adherence to the rules of the US Food and Drug Administration and the Scientific Advisory Committee of the Medical Outcomes Trust. We identified 20 individual questionnaires that included 10 generic instruments that assessed quality of life, six instruments specific for post-bariatric surgery, three instruments specific for breast surgery.

Conclusions

In post-bariatric patients, the BODY-Q was shown to be a more objective and confident measure for evaluating the quality of life of patients following post-bariatric surgery.

Level of Evidence III

For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Response to Comments Made on “Alternative Rhinoplasty Technique: Rotational Spreader Flap (Rabbit Flap)”

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2nypZAt

Is Latin America Ready to Identify Anaplastic Large Cell Lymphoma in Breast Implants Patients? Regional Encounter During the National Plastic Surgery Meeting in Cancun, Mexico

Abstract

Introduction

Anaplastic large cell lymphoma associated with breast implants is receiving increased attention. Most cases have been reported in Europe, North America (USA and Canada), Australia and New Zealand. Fewer cases have been reported in Latin America (including Mexico), Africa and Asia.

Methods

This report was delivered during our national plastic surgery meeting in Cancun in May 2017. Before the meeting, two participants reviewed the literature. The review was performed using the following information sources: PubMed, Embase, Cochrane, Fisterra, Google Scholar and LILACS, with entries from 1980 to August 2015 in several languages (English, Spanish, French and Portuguese). The results were revealed during the meeting to the other participants. The consensus was divided into two parts. The first part included an open-ended question regarding the incidence and prevalence of the problem. The second part included clinical scenarios with different items that were rated by the participants. After this activity, accordance among the responses was evaluated.

Results

Seven cases were reported during the meeting (3 from Mexico, 3 from Chile and 1 from Argentina). Fifty percent of the participants reported consulting with guidelines and clinical centers to help with potential cases. Most agreed that further studies must be done in cases of chronic seroma where the capsule plays an important role.

Discussion

A current debate exists about the incidence of this problem in Latin America because we did not report the same number of cases as Europe, Australia or North America. More studies are required to determine the differences among reports in Latin America.

Conclusion

Most representatives agreed that further studies must be done. Concern is increasing, and the problem is known. Other factors involved may be considered, and the problem must not be ignored.

No Level Assigned

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Breast-Conserving Surgery with Immediate Autologous Fat Grafting Reconstruction: Oncologic Outcomes

Abstract

Introduction

Autologous fat grafting (AFG; lipofilling, lipografting) has been used in delayed breast reconstruction. Recently, it has also been investigated as an alternative for immediate reconstruction in patients submitted to breast-conserving surgery (BCS). Although good aesthetic results have been reported, the oncologic safety of the procedure remains under investigation. This article aims to assess oncologic outcomes of patients submitted to BCS with immediate AFG reconstruction.

Methods

This study consisted of 65 patients undergoing BCS with AFG between January 2010 and January 2017. They were closely followed after surgery for a median period of 40.8 months. Locoregional and systemic recurrences were the primary endpoints of this study.

Results

Ten patients developed cancer recurrence (15.4%). The median time for recurrence was 58.9 months. Only two patients presented locoregional recurrence (LRR) (3.07%). Five patients had systemic recurrence (7.69%), and three had both systemic and LRR (4.61%). Median disease-free survival (DFS) was 42.2 months, and overall survival (OV) was 44.3 months. Recurrences were significantly associated with the number of metastatic axillary lymph nodes detected.

Conclusion

Oncologic outcomes of immediate AFG are similar to the results previously reported in BCS without AFG. Locoregional and systemic recurrences are associated with the presence of axillary metastases.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Commentary on: Medial Osteoectomy as a Routine Procedure in Rhinoplasty: Six-Year Experience with an Innovative Technique

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Six-Position, Frontal View Photography in Blepharoplasty: A Simple Method

Abstract

Background

Photography plays a pivotal role in patient education, photo-documentation, preoperative planning and postsurgical evaluation in plastic surgeries. It has long been serving as a bridge that facilitated communication not only between patients and doctors, but also among plastic surgeons from different countries. Although several basic principles and photographic methods have been proposed, there is no internationally accepted photography that could provide both static and dynamic information in blepharoplasty. In this article, we introduced a novel six-position, frontal view photography for thorough assessment in blepharoplasty.

Methods

From October 2013 to January 2017, 1068 patients who underwent blepharoplasty were enrolled in our clinical research. All patients received six-position, frontal view photography. Pictures were taken of the patients looking up, looking down, squeezing, smiling, looking ahead and with closed eyes. Conventionally, frontal view photography only contained the last two positions. Then, both novel six-position photographs and conventional two-position photographs were used to appraise postsurgical outcomes.

Results

Compared to conventional two-position, frontal view photography, six-position, frontal view photography can provide more detailed, thorough information about the eyes. It is of clinical significance in indicating underlying adhesion of skin/muscle/fat according to individual's features and assessing preoperative and postoperative dynamic changes and aesthetic outcomes.

Conclusion

Six-position, frontal view photography is technically uncomplicated while exhibiting static, dynamic and detailed information of the eyes. This innovative method is favorable in eye assessment, especially for revision blepharoplasty. We suggest using six-position, frontal view photography to obtain comprehensive photographs.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Brazilian Consensus Recommendation on the Use of Polymethylmethacrylate Filler in Facial and Corporal Aesthetics

Abstract

Background

Considering that aesthetic benefits can be obtained with the use of permanent filling materials, this work focuses on the development of a consensus regarding the facial and corporal use of polymethylmethacrylate (PMMA) filler in Brazil.

Methods

A questionnaire regarding PMMA treatment, which included items on the main indication, application site, volume of product applied, criteria for selection of the material, complications, contraindications, and individual professional experience, was distributed to the Expert Group members. In addition, the responses were summarized, constituting the starting point for the debate regarding the use of PMMA-based fillers on The First Brazilian PMMA Symposium to create a guideline to be followed in PMMA facial and corporal treatments.

Results

This survey involved 87,371 cases. PMMA treatment is recommended for restorative and aesthetic purposes in facial and corporal cases, particularly for facial balance. PMMA 30% filler is recommended in specific facial sites (nose, mentum, mandible angle, zygomatic arc, and malar). PMMA filler is contraindicated in other sites (lips) regardless of concentration. With regard to facial treatment, the juxtaperiostal is the application plane most recommended. For PMMA corporal application, intramuscular is the application plane most indicated, while intradermal and justadermal planes are contraindicated. The submuscular plane application is relative to PMMA filler concentration. The experts also inquired regarding the amount of PMMA recommended in each corporal site (50 mL in the calf, 100–150 mL in the gluteal region).

Conclusion

These recommendations provide a guideline for physicians, supporting them to perform safe and efficacious treatment with PMMA fillers.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Cavernous Hemangioma Between the Elastomer and Fibrous Capsule of a Breast Implant

Abstract

Hemangiomas are described in many locations, but breast hemangioma (BH) is rare, accounting for only 0.4% of all breast tumors. These tumors are difficult to diagnose preoperatively using conventional imaging modalities because they lack pathognomonic characteristics. Mammographic and sonographic appearances of BH were described in just a few case reports, and breast implant-related hemangiomas are even rarer. We report a case of the tumor arising in an atypical location—between the elastomer and fibrous capsule of a breast implant.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2szfTT4

Response to Comments Made on “Alternative Rhinoplasty Technique: Rotational Spreader Flap (Rabbit Flap)”

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2nypZAt

Breast-Conserving Surgery with Immediate Autologous Fat Grafting Reconstruction: Oncologic Outcomes

Abstract

Introduction

Autologous fat grafting (AFG; lipofilling, lipografting) has been used in delayed breast reconstruction. Recently, it has also been investigated as an alternative for immediate reconstruction in patients submitted to breast-conserving surgery (BCS). Although good aesthetic results have been reported, the oncologic safety of the procedure remains under investigation. This article aims to assess oncologic outcomes of patients submitted to BCS with immediate AFG reconstruction.

Methods

This study consisted of 65 patients undergoing BCS with AFG between January 2010 and January 2017. They were closely followed after surgery for a median period of 40.8 months. Locoregional and systemic recurrences were the primary endpoints of this study.

Results

Ten patients developed cancer recurrence (15.4%). The median time for recurrence was 58.9 months. Only two patients presented locoregional recurrence (LRR) (3.07%). Five patients had systemic recurrence (7.69%), and three had both systemic and LRR (4.61%). Median disease-free survival (DFS) was 42.2 months, and overall survival (OV) was 44.3 months. Recurrences were significantly associated with the number of metastatic axillary lymph nodes detected.

Conclusion

Oncologic outcomes of immediate AFG are similar to the results previously reported in BCS without AFG. Locoregional and systemic recurrences are associated with the presence of axillary metastases.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LId0qi

Six-Position, Frontal View Photography in Blepharoplasty: A Simple Method

Abstract

Background

Photography plays a pivotal role in patient education, photo-documentation, preoperative planning and postsurgical evaluation in plastic surgeries. It has long been serving as a bridge that facilitated communication not only between patients and doctors, but also among plastic surgeons from different countries. Although several basic principles and photographic methods have been proposed, there is no internationally accepted photography that could provide both static and dynamic information in blepharoplasty. In this article, we introduced a novel six-position, frontal view photography for thorough assessment in blepharoplasty.

Methods

From October 2013 to January 2017, 1068 patients who underwent blepharoplasty were enrolled in our clinical research. All patients received six-position, frontal view photography. Pictures were taken of the patients looking up, looking down, squeezing, smiling, looking ahead and with closed eyes. Conventionally, frontal view photography only contained the last two positions. Then, both novel six-position photographs and conventional two-position photographs were used to appraise postsurgical outcomes.

Results

Compared to conventional two-position, frontal view photography, six-position, frontal view photography can provide more detailed, thorough information about the eyes. It is of clinical significance in indicating underlying adhesion of skin/muscle/fat according to individual's features and assessing preoperative and postoperative dynamic changes and aesthetic outcomes.

Conclusion

Six-position, frontal view photography is technically uncomplicated while exhibiting static, dynamic and detailed information of the eyes. This innovative method is favorable in eye assessment, especially for revision blepharoplasty. We suggest using six-position, frontal view photography to obtain comprehensive photographs.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2orTrJC

Cavernous Hemangioma Between the Elastomer and Fibrous Capsule of a Breast Implant

Abstract

Hemangiomas are described in many locations, but breast hemangioma (BH) is rare, accounting for only 0.4% of all breast tumors. These tumors are difficult to diagnose preoperatively using conventional imaging modalities because they lack pathognomonic characteristics. Mammographic and sonographic appearances of BH were described in just a few case reports, and breast implant-related hemangiomas are even rarer. We report a case of the tumor arising in an atypical location—between the elastomer and fibrous capsule of a breast implant.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2szfTT4

FIERCE for a cure: Natick boot camp raises money for cancer research

FIERCE for a cure: Natick boot camp raises money for cancer research  Wicked Local PembrokeFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MEL0E5

Benign Paroxysmal Positional Vertigo in Children

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


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Thyroid cancer patients may need more aggressive treatment: Alberta researchers

Thyroid cancer patients may need more aggressive treatment: Alberta researchers  Globalnews.caFull coverage

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A scoring system to predict recurrence in patients with differentiated thyroid cancer

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


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A scoring system to predict recurrence in patients with differentiated thyroid cancer

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


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Experience of Immediate Ambulation and Early Discharge After Tumescent Anesthesia and Propofol Infusion in Cosmetic Breast Augmentation

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2nSX7CW

Patient-Reported Satisfaction Following Post-bariatric Surgery: A Systematic Review

Abstract

Introduction

The aims of our study were to identify studies that evaluated patient satisfaction following post-bariatric surgery, analyse existing questionnaires, and summarise their development, psychometric properties, and content.

Patients and Methods

A multistep search was undertaken on the web-based PubMed database from the National Library of Medicine to identify studies on patient satisfaction and quality of life following post-bariatric surgery. The authors summarised all the questionnaires used in every study and categorised them as generic, surgery specific, or ad hoc, and whether they contained either validated or unvalidated measures.

Results

Our search generated a total of 1754 articles. We performed a systematic review of the 12 remaining studies, because these had sufficient data and met the inclusion criteria. All the studies identified from the literature review were assessed to determine the type of surgery used, and whether or not the questionnaire used to analyse patient satisfaction had been validated. The questionnaires were analysed by reviewers to assess adherence to the rules of the US Food and Drug Administration and the Scientific Advisory Committee of the Medical Outcomes Trust. We identified 20 individual questionnaires that included 10 generic instruments that assessed quality of life, six instruments specific for post-bariatric surgery, three instruments specific for breast surgery.

Conclusions

In post-bariatric patients, the BODY-Q was shown to be a more objective and confident measure for evaluating the quality of life of patients following post-bariatric surgery.

Level of Evidence III

For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Is Latin America Ready to Identify Anaplastic Large Cell Lymphoma in Breast Implants Patients? Regional Encounter During the National Plastic Surgery Meeting in Cancun, Mexico

Abstract

Introduction

Anaplastic large cell lymphoma associated with breast implants is receiving increased attention. Most cases have been reported in Europe, North America (USA and Canada), Australia and New Zealand. Fewer cases have been reported in Latin America (including Mexico), Africa and Asia.

Methods

This report was delivered during our national plastic surgery meeting in Cancun in May 2017. Before the meeting, two participants reviewed the literature. The review was performed using the following information sources: PubMed, Embase, Cochrane, Fisterra, Google Scholar and LILACS, with entries from 1980 to August 2015 in several languages (English, Spanish, French and Portuguese). The results were revealed during the meeting to the other participants. The consensus was divided into two parts. The first part included an open-ended question regarding the incidence and prevalence of the problem. The second part included clinical scenarios with different items that were rated by the participants. After this activity, accordance among the responses was evaluated.

Results

Seven cases were reported during the meeting (3 from Mexico, 3 from Chile and 1 from Argentina). Fifty percent of the participants reported consulting with guidelines and clinical centers to help with potential cases. Most agreed that further studies must be done in cases of chronic seroma where the capsule plays an important role.

Discussion

A current debate exists about the incidence of this problem in Latin America because we did not report the same number of cases as Europe, Australia or North America. More studies are required to determine the differences among reports in Latin America.

Conclusion

Most representatives agreed that further studies must be done. Concern is increasing, and the problem is known. Other factors involved may be considered, and the problem must not be ignored.

No Level Assigned

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Commentary on: Medial Osteoectomy as a Routine Procedure in Rhinoplasty: Six-Year Experience with an Innovative Technique

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pfqhxo

Complication of AQUAfilling ® Gel Injection for Breast Augmentation: Case Report of One Case and Review of Literature

Abstract

Introduction

Augmentation mammoplasty is one of the most popular aesthetic operations in the world. In Korea, one of the fillers used for breast augmentation is AQUAfilling^® gel (Biomedica. spol, s,r,o, Czech Republic). AQUAfilling^® gel is a hydrophilic gel composed of 98% sodium chloride solution (0.9%) and 2% cation copolyamide.

Methods

This is a case report describing a patient that suffered complications after AQUAfilling^® gel injection for breast augmentation.

Results

A 32-year-old female patient was referred to our plastic surgery department with a chief complaint of repeated wound dehiscence and fluid discharge involving both breasts. She was treated via surgical intervention for removal of necrotic infected tissue and filler, as well as massive irrigation three times. After the third surgery, there were no complications, including infection or dehiscence, during a 1-year follow-up period.

Conclusions

Although AQUAfilling^® gel is easy to inject and is natural looking, once a complication occurs, treatment is difficult. Also, there are concerns regarding toxicity of the gel material and its influence on surrounding tissues. Hence, sufficient evidences of long-term safety must be accumulated and proved, until which time the aesthetic use of the unapproved filler must be restricted.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2F0DpN6

Experience of Immediate Ambulation and Early Discharge After Tumescent Anesthesia and Propofol Infusion in Cosmetic Breast Augmentation

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2nSX7CW