MULRECON: a web-based imaging viewer for visualization of volumetric images

Publication date: Available online 19 September 2018

Source: Current Problems in Diagnostic Radiology

Author(s): Jens Borgbjerg

Abstract

Recent developments in web technology allow pixel-level manipulation of radiologic images. This paper presents an easily accessible imaging viewer for visualization of volumetric datasets which leverages modern web technology. The viewer is designed to enable on-the-fly multiplanar reconstructions with different projectional techniques, and these can be manipulated as in a Picture Archiving and Communication System. The application opens up possibilities for teaching and demonstrational purposes. Step-by-step instructions for how to use are provided and the source code is made available.

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MULRECON: a web-based imaging viewer for visualization of volumetric images

Publication date: Available online 19 September 2018

Source: Current Problems in Diagnostic Radiology

Author(s): Jens Borgbjerg

Abstract

Recent developments in web technology allow pixel-level manipulation of radiologic images. This paper presents an easily accessible imaging viewer for visualization of volumetric datasets which leverages modern web technology. The viewer is designed to enable on-the-fly multiplanar reconstructions with different projectional techniques, and these can be manipulated as in a Picture Archiving and Communication System. The application opens up possibilities for teaching and demonstrational purposes. Step-by-step instructions for how to use are provided and the source code is made available.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pn2KKX

Impact of Climate Change on Pollen and Respiratory Disease

Abstract

Purpose of Review

A warming world will impact everyone and everything. The practice of allergic and respiratory disease will not be excepted. All the impacts will be impossible to anticipate. This review is intended to discuss significant factors related to individuals with allergic and respiratory disease.

Recent Findings

Recent findings include the increased growth of allergenic plants in response to higher carbon dioxide levels and warmer temperatures. This also contributes to the increased production of pollen as well as the appearance of allergenic species in new climactic areas. Stinging insects will extend their ranges into northern areas where they have not previously been a problem. The shift and extension of pollen seasons with warmer springs and later frosts have already been observed. Recent severe hurricanes and flooding events may be just the harbinger of increasing damp housing exposure related to sea level rise. Evidence is accumulating that indicates the expected higher number of ozone alert days and increased pollution in populated areas is bringing increases in pollen potency. Finally, increased exposure to smoke and particles from wild fires, resulting from heat waves, will contribute to the general increase in respiratory disease.

Summary

The practice of allergy being closely aligned with environmental conditions will be especially impacted. Allergists should consider increasing educational activities aimed at making patients more aware of air quality conditions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MIfGo1

Impact of Climate Change on Pollen and Respiratory Disease

Abstract

Purpose of Review

A warming world will impact everyone and everything. The practice of allergic and respiratory disease will not be excepted. All the impacts will be impossible to anticipate. This review is intended to discuss significant factors related to individuals with allergic and respiratory disease.

Recent Findings

Recent findings include the increased growth of allergenic plants in response to higher carbon dioxide levels and warmer temperatures. This also contributes to the increased production of pollen as well as the appearance of allergenic species in new climactic areas. Stinging insects will extend their ranges into northern areas where they have not previously been a problem. The shift and extension of pollen seasons with warmer springs and later frosts have already been observed. Recent severe hurricanes and flooding events may be just the harbinger of increasing damp housing exposure related to sea level rise. Evidence is accumulating that indicates the expected higher number of ozone alert days and increased pollution in populated areas is bringing increases in pollen potency. Finally, increased exposure to smoke and particles from wild fires, resulting from heat waves, will contribute to the general increase in respiratory disease.

Summary

The practice of allergy being closely aligned with environmental conditions will be especially impacted. Allergists should consider increasing educational activities aimed at making patients more aware of air quality conditions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MIfGo1

A birch sublingual allergy immunotherapy (SLIT) tablet educes rhinoconjunctivitis symptoms when exposed to birch and oak and induces IgG4 to allergens from all trees in the birch homologous group

Allergy, Volume 0, Issue ja, -Not available-.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PRmpOf

Impact of Climate Change on Pollen and Respiratory Disease

Abstract

Purpose of Review

A warming world will impact everyone and everything. The practice of allergic and respiratory disease will not be excepted. All the impacts will be impossible to anticipate. This review is intended to discuss significant factors related to individuals with allergic and respiratory disease.

Recent Findings

Recent findings include the increased growth of allergenic plants in response to higher carbon dioxide levels and warmer temperatures. This also contributes to the increased production of pollen as well as the appearance of allergenic species in new climactic areas. Stinging insects will extend their ranges into northern areas where they have not previously been a problem. The shift and extension of pollen seasons with warmer springs and later frosts have already been observed. Recent severe hurricanes and flooding events may be just the harbinger of increasing damp housing exposure related to sea level rise. Evidence is accumulating that indicates the expected higher number of ozone alert days and increased pollution in populated areas is bringing increases in pollen potency. Finally, increased exposure to smoke and particles from wild fires, resulting from heat waves, will contribute to the general increase in respiratory disease.

Summary

The practice of allergy being closely aligned with environmental conditions will be especially impacted. Allergists should consider increasing educational activities aimed at making patients more aware of air quality conditions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MIfGo1

A birch sublingual allergy immunotherapy (SLIT) tablet educes rhinoconjunctivitis symptoms when exposed to birch and oak and induces IgG4 to allergens from all trees in the birch homologous group

Allergy, Volume 0, Issue ja, -Not available-.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PRmpOf

Identification of pathogenic genes and upstream regulators in allergic rhinitis

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Yanhua Lei, Ping Guo, Jun An, Chao Guo, Fengxiang Lu, Minglei Liu

Abstract

Background

Allergic rhinitis (AR) is the main cause of irreversible blindness in older individuals. Our study aims to identify the key genes and upstream regulators in AR.

Methods

To screen pathogenic genes of AR, an integrated analysis was performed by using the microarray datasets in AR derived from the Gene Expression Omnibus (GEO) database. The functional annotation and potential pathways of differentially expressed genes (DEGs) were further discovered by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. We constructed the AR-specific transcriptional regulatory network to find the crucial transcriptional factors (TFs) which target the DEGs in AR. Electronic validation was performed to verify the DEGs obtained by integrated analysis.

Results

From two GEO datasets obtained, we identified 793 DEGs (460 up-regulated and 333 down-regulated genes) between AR and normal control (NC). After GO and KEGG analysis, chronic inflammatory response and MAPK signaling pathway were significantly enriched pathways for DEGs. The expression of 6 genes (CLC, CST1, CRTAM, ILK, STAT1, and POSTN) was detected. The 6 genes in GEO: GSE51392 dataset played the same pattern with that in our integrated analysis.

Conclusions

The dysregulation of 3 genes (CST1, CLC and STAT1) may be involved in the pathogenesis of AR. AP-1 was associated with AR by regulating CST1 and CLC. Our finding can contribute to developing new potential biomarkers, revealing the underlying pathogenesis, and further raising new therapeutic targets for AR.

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Dacryoendoscopy-Assisted Nasal Endoscopic Marsupialization for Congenital Dacryocystocele

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Tushar Sarbajna, Yasuhiro Takahashi, Ma. Regina Paula Valencia, Marian Grace Ana-Magadia, Eri Ishikawa, Hirohiko Kakizaki

Abstract

Objective

To examine the surgical outcome of dacryoendoscopy-assisted nasal endoscopic marsupialization for congenital dacryocystocele.

Methods

This is a retrospective, observational study that included 7 sides of 6 patients with congenital dacryocystocele. The surgical indication in 5 of the patients was acute dacryocystitis while one of the patients had no spontaneous resolution after long-term observation. Dacryoendoscopy was used for visualization of the lacrimal cavity, direct probing of the obstruction at the common canaliculus, and localisation of a deflated intranasal cyst after an initial incision of the cyst. Surgical success was defined when the following postoperative conditions were satisfied: no epiphora, normal tear meniscus height, and complete clearance of the dye 5 minutes after instilling a drop of 2% fluorescein solution into the inferior conjunctional fornix.

Results

Out of 6 patients, 2 patients were noted to have membranous common canalicular obstruction. Postoperative follow-up ranged from 11 days to 3 months. Surgical success was achieved in all patients without any complication.

Conclusions

Dacryoendoscopy-assisted nasal endoscopic marsupialization is an effective surgical management for congenital dacryocystocele.

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Predictive ABILITY of bedside nasal endoscopy to diagnose invasive fungal sinusitis in a pediatric population

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Carolyn L. Mulvey, Mark D. Rizzi, Adva Buzi

Abstract

Introduction

Invasive fungal sinusitis (IFS) is a rare but deadly clinical entity that occurs in immunocompromised patients. Diagnosis in children typically requires operative biopsies under general anesthesia, which has associated risks. Findings on bedside nasal endoscopy (BNE) can be used with history, exam, and imaging to determine the need for surgery, however, the accuracy of this tool has not been established among pediatric patients.

Methods

Patients who underwent BNE for evaluation of IFS from 2008-2016 at the Children's Hospital of Philadelphia were identified using Current Procedural Terminology (CPT) codes. Retrospective chart analysis was performed and included underlying diagnoses, presenting signs and symptoms, imaging findings, endoscopic findings and outcomes.

Results

Nineteen patients were identified who underwent evaluation for IFS using BNE during the period studied. Eight patients had exam findings that were concerning for IFS, including debris or crusting, darkened or pale mucosa, or copious, thick and/or purulent secretions. Immediate operative biopsies and debridement revealed IFS in six of eight patients. Eleven patients had exam findings deemed not concerning for IFS including mucosal edema, mucous without purulence, or normal findings. Six of eleven patients underwent operative biopsy despite negative endoscopy, and five were observed clinically. None of the 11 patients with negative bedside endoscopy developed IFS.

Conclusions

All patients with IFS had concerning exam findings on endoscopy and were treated with immediate biopsies and debridement. No patient with normal or non-concerning findings on BNE progressed to have invasive fungal sinusitis. While suspicion for IFS in immunocompromised children must remain high, BNE is feasible and useful in its assessment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xrF4cP

Identification of pathogenic genes and upstream regulators in allergic rhinitis

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Yanhua Lei, Ping Guo, Jun An, Chao Guo, Fengxiang Lu, Minglei Liu

Abstract

Background

Allergic rhinitis (AR) is the main cause of irreversible blindness in older individuals. Our study aims to identify the key genes and upstream regulators in AR.

Methods

To screen pathogenic genes of AR, an integrated analysis was performed by using the microarray datasets in AR derived from the Gene Expression Omnibus (GEO) database. The functional annotation and potential pathways of differentially expressed genes (DEGs) were further discovered by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. We constructed the AR-specific transcriptional regulatory network to find the crucial transcriptional factors (TFs) which target the DEGs in AR. Electronic validation was performed to verify the DEGs obtained by integrated analysis.

Results

From two GEO datasets obtained, we identified 793 DEGs (460 up-regulated and 333 down-regulated genes) between AR and normal control (NC). After GO and KEGG analysis, chronic inflammatory response and MAPK signaling pathway were significantly enriched pathways for DEGs. The expression of 6 genes (CLC, CST1, CRTAM, ILK, STAT1, and POSTN) was detected. The 6 genes in GEO: GSE51392 dataset played the same pattern with that in our integrated analysis.

Conclusions

The dysregulation of 3 genes (CST1, CLC and STAT1) may be involved in the pathogenesis of AR. AP-1 was associated with AR by regulating CST1 and CLC. Our finding can contribute to developing new potential biomarkers, revealing the underlying pathogenesis, and further raising new therapeutic targets for AR.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xr5NGt

Dacryoendoscopy-Assisted Nasal Endoscopic Marsupialization for Congenital Dacryocystocele

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Tushar Sarbajna, Yasuhiro Takahashi, Ma. Regina Paula Valencia, Marian Grace Ana-Magadia, Eri Ishikawa, Hirohiko Kakizaki

Abstract

Objective

To examine the surgical outcome of dacryoendoscopy-assisted nasal endoscopic marsupialization for congenital dacryocystocele.

Methods

This is a retrospective, observational study that included 7 sides of 6 patients with congenital dacryocystocele. The surgical indication in 5 of the patients was acute dacryocystitis while one of the patients had no spontaneous resolution after long-term observation. Dacryoendoscopy was used for visualization of the lacrimal cavity, direct probing of the obstruction at the common canaliculus, and localisation of a deflated intranasal cyst after an initial incision of the cyst. Surgical success was defined when the following postoperative conditions were satisfied: no epiphora, normal tear meniscus height, and complete clearance of the dye 5 minutes after instilling a drop of 2% fluorescein solution into the inferior conjunctional fornix.

Results

Out of 6 patients, 2 patients were noted to have membranous common canalicular obstruction. Postoperative follow-up ranged from 11 days to 3 months. Surgical success was achieved in all patients without any complication.

Conclusions

Dacryoendoscopy-assisted nasal endoscopic marsupialization is an effective surgical management for congenital dacryocystocele.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PSb6FE

Predictive ABILITY of bedside nasal endoscopy to diagnose invasive fungal sinusitis in a pediatric population

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Carolyn L. Mulvey, Mark D. Rizzi, Adva Buzi

Abstract

Introduction

Invasive fungal sinusitis (IFS) is a rare but deadly clinical entity that occurs in immunocompromised patients. Diagnosis in children typically requires operative biopsies under general anesthesia, which has associated risks. Findings on bedside nasal endoscopy (BNE) can be used with history, exam, and imaging to determine the need for surgery, however, the accuracy of this tool has not been established among pediatric patients.

Methods

Patients who underwent BNE for evaluation of IFS from 2008-2016 at the Children's Hospital of Philadelphia were identified using Current Procedural Terminology (CPT) codes. Retrospective chart analysis was performed and included underlying diagnoses, presenting signs and symptoms, imaging findings, endoscopic findings and outcomes.

Results

Nineteen patients were identified who underwent evaluation for IFS using BNE during the period studied. Eight patients had exam findings that were concerning for IFS, including debris or crusting, darkened or pale mucosa, or copious, thick and/or purulent secretions. Immediate operative biopsies and debridement revealed IFS in six of eight patients. Eleven patients had exam findings deemed not concerning for IFS including mucosal edema, mucous without purulence, or normal findings. Six of eleven patients underwent operative biopsy despite negative endoscopy, and five were observed clinically. None of the 11 patients with negative bedside endoscopy developed IFS.

Conclusions

All patients with IFS had concerning exam findings on endoscopy and were treated with immediate biopsies and debridement. No patient with normal or non-concerning findings on BNE progressed to have invasive fungal sinusitis. While suspicion for IFS in immunocompromised children must remain high, BNE is feasible and useful in its assessment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xrF4cP

Employing bioabsorbable grafts in two-stage laryngotracheal reconstruction of pediatric patient with severe subglottic stenosis and history of airway surgery

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Elliot Le, Lenhanh Tran

Abstract

A 16-month old female was referred to our practice for laryngotracheal reconstruction (LTR) for acquired subglottic stenosis (SGS) diagnosed at 4 weeks of age due to prolonged intubation. She has a history of open thoracic repair of congenital tracheoesophageal fistula that was complicated by a pneumothorax and phrenic nerve paralysis. We performed a variation of an anterior and posterior cricoid split LTR with tracheal stenting in order to avoid risks of pulmonary morbidity from costochondral cartilage harvesting. We report the first LTR to use KLS Martin Resorb-XG bioabsorbable implant (poly-L-lactic acid & poly glycolic acid) as a substitute graft for autologous cartilage in a patient with severe SGS and a history of airway surgeries. The patient had an uncomplicated recovery and had a patent trachea on laryngobronchoscopy at 4, 13, and 22 months after surgery.

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Rhinolithiasis: A Misleading Entity.

Related Articles

Rhinolithiasis: A Misleading Entity.

Allergy Rhinol (Providence). 2018 Jan-Dec;9:2152656718783596

Authors: Adib H, Natout MAE, Zaytoun G, Hadi UA

Abstract
Introduction: Rhinolithiasis is a rare entity; it entails a stone located in the nasal cavity. The entity presents with different signs and symptoms that can be easily confused with other more common clinical entities such as chronic rhinosinusitis. However, it can also mimic sinonasal tumors, making its proper diagnosis crucial.
Materials and Methods: In this article, we present a case series of 15 patients over the past 13 years between 2002 and 2015 who were seen in the clinics at the American University of Beirut Medical Center. We will shed light on the common presenting symptoms, physical examination findings, proper diagnostic modalities, and treatment options. Our data will be compared to the literature.
Conclusion: Rhinolithiasis could present with a wide spectrum of signs and symptoms and could be overlooked or mistaken for other diagnosis such as sinusitis or malignancy. It could be differentiated from other entities by rigid nasal endoscopy and computed tomography scan. The diagnosis of rhinolithiasis requires a high index of suspicion.

PMID: 30228929 [PubMed]

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Effect of Health Promotion on Allergic Rhinitis by Infrared-C Ray Irradiation

Condition:   Allergic Rhinitis Interventions:   Device: infrared-C ray irradiation;   Device: eye mask;   Drug: Xyzal Oral Product;   Drug: Fluticasone Furoate Sponsors:   Nanhua University;   Buddhist Tzu Chi General Hospital;   Solano Semiconductor Technology., LTD. Completed (Source: ClinicalTrials.gov)

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Introduction and Maintenance of Still Eating Protein Blends in Support of Infant Nutritional Goals

Condition:   Food Allergy Intervention:   Dietary Supplement: Food Supplement Sponsor:   Northwestern University Completed (Source: ClinicalTrials.gov)

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Patient Portal - Flu Reminder Recall

Conditions:   Influenza;   Respiratory Tract Infections;   Vaccines Interventions:   Behavioral: 1 MyChart R/R;   Behavioral: 2 MyChart R/R;   Behavioral: 3 MyChart R/R Sponsors:   University of California, Los Angeles;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Study Evaluating the Efficacy and Safety of Fexofenadine in Subjects Suffering From Seasonal Allergic Rhinitis in Presence of Pollutants

Condition:   Rhinitis Seasonal Interventions:   Drug: Fexofenadine M016455;   Drug: Placebo Sponsor:   Sanofi Not yet recruiting (Source: ClinicalTrials.gov)

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Serum Immunologic Markers Levels in During the Delivery

Condition:   Immunologic Markers Intervention:   Diagnostic Test: Blood sampling Sponsor:   Brno University Hospital Not yet recruiting (Source: ClinicalTrials.gov)

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COMISS Score for Detection of Cow's Milk Protein Allergy in Children With Recrrent or Persistent Gastrointestinal Manifistations in Infants Attending Assuit University Children Hospital - Egypt

Condition:   Cow Milk Allergy Intervention:   Diagnostic Test: COMISS score Sponsor:   caroline maher Not yet recruiting (Source: ClinicalTrials.gov)

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Effect of Health Promotion on Allergic Rhinitis by Infrared-C Ray Irradiation

Condition:   Allergic Rhinitis Interventions:   Device: infrared-C ray irradiation;   Device: eye mask;   Drug: Xyzal Oral Product;   Drug: Fluticasone Furoate Sponsors:   Nanhua University;   Buddhist Tzu Chi General Hospital;   Solano Semiconductor Technology., LTD. Completed (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xBFrRo

Introduction and Maintenance of Still Eating Protein Blends in Support of Infant Nutritional Goals

Condition:   Food Allergy Intervention:   Dietary Supplement: Food Supplement Sponsor:   Northwestern University Completed (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NqM3Na

Patient Portal - Flu Reminder Recall

Conditions:   Influenza;   Respiratory Tract Infections;   Vaccines Interventions:   Behavioral: 1 MyChart R/R;   Behavioral: 2 MyChart R/R;   Behavioral: 3 MyChart R/R Sponsors:   University of California, Los Angeles;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Study Evaluating the Efficacy and Safety of Fexofenadine in Subjects Suffering From Seasonal Allergic Rhinitis in Presence of Pollutants

Condition:   Rhinitis Seasonal Interventions:   Drug: Fexofenadine M016455;   Drug: Placebo Sponsor:   Sanofi Not yet recruiting (Source: ClinicalTrials.gov)

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Serum Immunologic Markers Levels in During the Delivery

Condition:   Immunologic Markers Intervention:   Diagnostic Test: Blood sampling Sponsor:   Brno University Hospital Not yet recruiting (Source: ClinicalTrials.gov)

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COMISS Score for Detection of Cow's Milk Protein Allergy in Children With Recrrent or Persistent Gastrointestinal Manifistations in Infants Attending Assuit University Children Hospital - Egypt

Condition:   Cow Milk Allergy Intervention:   Diagnostic Test: COMISS score Sponsor:   caroline maher Not yet recruiting (Source: ClinicalTrials.gov)

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HIV Infection and Risk Related Coinfections/Comorbidities in Indonesia

Condition:   HIV Intervention:   Sponsors:   Ina-Respond;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Specialized Pro‐Resolving Lipid Mediators in Experimental Periodontitis:A Systematic Review

Oral Diseases, Volume 0, Issue ja, -Not available-.


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Increased immunoreactivity of TRPM8 in cutaneous squamous cell carcinoma

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


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Specialized Pro‐Resolving Lipid Mediators in Experimental Periodontitis:A Systematic Review

Oral Diseases, Volume 0, Issue ja, -Not available-.


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Increased immunoreactivity of TRPM8 in cutaneous squamous cell carcinoma

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


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Evaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners

We report the results of a randomised placebo-controlled double-blind study on psychophysical tests of the effects of AUT00063 on temporal processing by CI listeners. The study measured the upper limit of temporal pitch, gap detection, and discrimination of low rates (centred on 120  pps) for monopolar pulse trains presented to an apical electrode. The upper limit was measured using the optimally efficient midpoint comparison (MPC) pitch-ranking procedure; thresholds were obtained for the other two measures using an adaptive procedure. Twelve CI users (MedEl and Cochlear) were tested before and after two periods of AUT00063 or placebo in a within-subject crossover study. No significant differences occurred between post-drug and post-placebo conditions. This absence of effect occurred desp...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pnKUYb

Evaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners

We report the results of a randomised placebo-controlled double-blind study on psychophysical tests of the effects of AUT00063 on temporal processing by CI listeners. The study measured the upper limit of temporal pitch, gap detection, and discrimination of low rates (centred on 120  pps) for monopolar pulse trains presented to an apical electrode. The upper limit was measured using the optimally efficient midpoint comparison (MPC) pitch-ranking procedure; thresholds were obtained for the other two measures using an adaptive procedure. Twelve CI users (MedEl and Cochlear) were tested before and after two periods of AUT00063 or placebo in a within-subject crossover study. No significant differences occurred between post-drug and post-placebo conditions. This absence of effect occurred desp...

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Targeting IL-23 in Crohn's disease.

Authors: Sedda S, Bevivino G, Monteleone G Abstract INTRODUCTION: Interleukin (IL)-23, a cytokine produced by antigen presenting cells, targets both T cells and non-T cell types with the down-stream effect of enhancing inflammatory pathways. Genome-wide association studies and data from human and mouse models of intestinal inflammation support the pathogenic role of IL-23 in Crohn's disease (CD), an immune-mediated disorder that can involve any part of the gastrointestinal tract. Areas covered: This review summarizes the available data on the role of IL-23 in CD and discusses the therapeutic relevance of blocking the function of IL-23 in this disorder. Expert commentary: The use of biologic drugs, such as anti-TNF and anti-integrins, has largely improved the management of CD patien...

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Targeting IL-23 in Crohn's disease.

Authors: Sedda S, Bevivino G, Monteleone G Abstract INTRODUCTION: Interleukin (IL)-23, a cytokine produced by antigen presenting cells, targets both T cells and non-T cell types with the down-stream effect of enhancing inflammatory pathways. Genome-wide association studies and data from human and mouse models of intestinal inflammation support the pathogenic role of IL-23 in Crohn's disease (CD), an immune-mediated disorder that can involve any part of the gastrointestinal tract. Areas covered: This review summarizes the available data on the role of IL-23 in CD and discusses the therapeutic relevance of blocking the function of IL-23 in this disorder. Expert commentary: The use of biologic drugs, such as anti-TNF and anti-integrins, has largely improved the management of CD patien...

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Growth Hormone Therapy for a Child With Severe Cognitive Impairment

Growth Hormone Therapy for a Child With Severe Cognitive Impairment  AAP NewsFull coverage

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Growth Hormone Therapy for a Child With Severe Cognitive Impairment

Growth Hormone Therapy for a Child With Severe Cognitive Impairment  AAP NewsFull coverage

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Fabrication and characterization of 3D‐printed elastic auricular scaffolds: A pilot study

The Laryngoscope, EarlyView.


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In reference to accuracy and reliability of the flow coupler in postoperative monitoring of head and neck free flaps

The Laryngoscope, EarlyView.


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In reference to accuracy and reliability of the flow coupler in postoperative monitoring of head and neck free flaps

The Laryngoscope, EarlyView.


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Diagnosis of vocal cord leukoplakia: The role of a novel narrow band imaging endoscopic classification

The Laryngoscope, EarlyView.


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In Response to In Reference to Intervention for Elevated Intracranial Pressure Improves Success Rate After Repair of Spontaneous Cerebrospinal Fluid Leaks

The Laryngoscope, EarlyView.


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In Response to In Reference to Intervention for Elevated Intracranial Pressure Improves Success Rate After Repair of Spontaneous Cerebrospinal Fluid Leaks

The Laryngoscope, EarlyView.


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Patient‐reported olfaction improves following outside‐in Draf III frontal sinus surgery for chronic rhinosinusitis

The Laryngoscope, EarlyView.


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Patient‐reported olfaction improves following outside‐in Draf III frontal sinus surgery for chronic rhinosinusitis

The Laryngoscope, EarlyView.


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Readmission after surgery for oropharyngeal cancer: An analysis of rates, causes, and risk factors

The Laryngoscope, EarlyView.


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Prevalence and resource utilization for vocal fold paralysis/paresis after esophagectomy

The Laryngoscope, EarlyView.


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Prevalence and resource utilization for vocal fold paralysis/paresis after esophagectomy

The Laryngoscope, EarlyView.


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Voice Outcome Measures for Adult Patients With Unilateral Vocal Fold Paralysis: A Systematic Review

The Laryngoscope, EarlyView.


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Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome

Rebecca L. McCullough, Megan R. McMullen, Kyle L. Poulsen, Adam Kim, M. Edward Medof, Laura E. Nagy (Source: Frontiers in Immunology)

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Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome

Rebecca L. McCullough, Megan R. McMullen, Kyle L. Poulsen, Adam Kim, M. Edward Medof, Laura E. Nagy (Source: Frontiers in Immunology)

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Corrigendum: Natural Killer Cell Activity and Interleukin-12 in Metabolically Healthy versus Metabolically Unhealthy Overweight Individuals

Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Jong Ho Lee (Source: Frontiers in Immunology)

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Corrigendum: Natural Killer Cell Activity and Interleukin-12 in Metabolically Healthy versus Metabolically Unhealthy Overweight Individuals

Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Jong Ho Lee (Source: Frontiers in Immunology)

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Anti-glucocorticoid-induced Tumor Necrosis Factor –Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects

Jonathan E. Schoenhals, Taylor R. Cushman, Hampartsoum B. Barsoumian, Ailin Li, Alexandra P. Cadena, Sharareh Niknam, Ahmed I. Younes, Mauricio da Silva Caetano, Maria Angelica Cortez, James W. Welsh (Source: Frontiers in Immunology)

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Anti-glucocorticoid-induced Tumor Necrosis Factor –Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects

Jonathan E. Schoenhals, Taylor R. Cushman, Hampartsoum B. Barsoumian, Ailin Li, Alexandra P. Cadena, Sharareh Niknam, Ahmed I. Younes, Mauricio da Silva Caetano, Maria Angelica Cortez, James W. Welsh (Source: Frontiers in Immunology)

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The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT)

Anna S. Świerzko, Mateusz Michalski, Anna Sokołowska, Mateusz Nowicki, Łukasz Eppa, Agnieszka Szala-Poździej, Iwona Mitrus, Anna Szmigielska-Kapłon, Małgorzata Sobczyk-Kruszelnicka, Katarzyna Michalak, Aleksandra Gołos, Agnieszka Wierzbowska, Sebastian Giebel, Krzysztof Jamroziak, Marek L. Kowalski, Olga Brzezińska, Steffen Thiel, Jens C. Jensenius, Katarzyna Kasperkiewicz, Maciej Cedzyński (Source: Frontiers in Immunology)

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The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT)

Anna S. Świerzko, Mateusz Michalski, Anna Sokołowska, Mateusz Nowicki, Łukasz Eppa, Agnieszka Szala-Poździej, Iwona Mitrus, Anna Szmigielska-Kapłon, Małgorzata Sobczyk-Kruszelnicka, Katarzyna Michalak, Aleksandra Gołos, Agnieszka Wierzbowska, Sebastian Giebel, Krzysztof Jamroziak, Marek L. Kowalski, Olga Brzezińska, Steffen Thiel, Jens C. Jensenius, Katarzyna Kasperkiewicz, Maciej Cedzyński (Source: Frontiers in Immunology)

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Going to Bat(s) for Studies of Disease Tolerance

Judith N. Mandl, Caitlin Schneider, David S. Schneider, Michelle L. Baker (Source: Frontiers in Immunology)

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Genetic Alterations of TRAF Proteins in Human Cancers

Sining Zhu, Juan Jin, Samantha Gokhale, Angeli M. Lu, Haiyan Shan, Jianjun Feng, Ping Xie (Source: Frontiers in Immunology)

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Genetic Alterations of TRAF Proteins in Human Cancers

Sining Zhu, Juan Jin, Samantha Gokhale, Angeli M. Lu, Haiyan Shan, Jianjun Feng, Ping Xie (Source: Frontiers in Immunology)

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Host –Parasite Interactions Promote Disease Tolerance to Intestinal Helminth Infection

Irah L. King, Yue Li (Source: Frontiers in Immunology)

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CD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance

Niels W.C.J. van de Donk, Saad Z. Usmani (Source: Frontiers in Immunology)

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CD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance

Niels W.C.J. van de Donk, Saad Z. Usmani (Source: Frontiers in Immunology)

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A Novel Antigen-Sampling Cell in the Teleost Gill Epithelium With the Potential for Direct Antigen Presentation in Mucosal Tissue

Goshi Kato, Haruya Miyazawa, Yumiko Nakayama, Yuki Ikari, Hidehiro Kondo, Takuya Yamaguchi, Motohiko Sano, Uwe Fischer (Source: Frontiers in Immunology)

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A Novel Antigen-Sampling Cell in the Teleost Gill Epithelium With the Potential for Direct Antigen Presentation in Mucosal Tissue

Goshi Kato, Haruya Miyazawa, Yumiko Nakayama, Yuki Ikari, Hidehiro Kondo, Takuya Yamaguchi, Motohiko Sano, Uwe Fischer (Source: Frontiers in Immunology)

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Circulating exosomes cause loss of immunological balance in multiple sclerosis

Clinical and Experimental Neuroimmunology, EarlyView. (Source: Clinical and Experimental Neuroimmunology)

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Circulating exosomes cause loss of immunological balance in multiple sclerosis

Clinical and Experimental Neuroimmunology, EarlyView. (Source: Clinical and Experimental Neuroimmunology)

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Eugenol allergy mimicking burning mouth syndrome

Contact Dermatitis, EarlyView.


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Eugenol allergy mimicking burning mouth syndrome

Contact Dermatitis, EarlyView.


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Impact of postoperative radiotherapy on survival and loco-regional control in node-negative oral cavity tumours classified as T3 using the AJCC Cancer Staging Manual eighth edition

According to the eighth edition of the AJCC Cancer Staging Manual (AJCC8), a depth of invasion (DOI)>10mm is classified as pT3, representing a locally advanced tumour requiring postoperative radiotherapy (PORT). When node-negative, however, evidence regarding whether PORT improves loco-regional control or survival is unclear. To clarify this, two cohorts of patients were studied: (1) patients classified as pT3N0 by the seventh edition of the AJCC manual (AJCC7), with DOI>10mm and a tumour diameter>4cm (17 patients who received PORT), and (2) patients classified as pT1N0 and pT2N0 by AJCC7, with DOI>10mm and a tumour diameter (Source: International Journal of Oral and Maxillofacial Surgery)

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Management of nasopharyngeal teratomas associated with cleft palate

Nasopharyngeal teratomas are rare tumours, responsible for a high birth mortality rate from acute respiratory distress. Palatine localization can lead to an embryopathogenic mechanical obstacle responsible for a cleft palate. The aim of this study was to update current knowledge concerning the management of this rare pathological association.We conducted a multicentre, retrospective study by case analysis. The inclusion criteria were patients of any age under care for a nasopharyngeal teratoma associated with a velopalatine cleft. (Source: International Journal of Oral and Maxillofacial Surgery)

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Management of nasopharyngeal teratomas associated with cleft palate

Nasopharyngeal teratomas are rare tumours, responsible for a high birth mortality rate from acute respiratory distress. Palatine localization can lead to an embryopathogenic mechanical obstacle responsible for a cleft palate. The aim of this study was to update current knowledge concerning the management of this rare pathological association.We conducted a multicentre, retrospective study by case analysis. The inclusion criteria were patients of any age under care for a nasopharyngeal teratoma associated with a velopalatine cleft. (Source: International Journal of Oral and Maxillofacial Surgery)

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Treatment of skeletal open bite using a navigation system: CAD/CAM osteotomy and drilling guides combined with pre-bent titanium plates

This study used a navigation system for the correction of severe skeletal open bite in order to accurately transfer the virtual plan to the actual operation and achieve precise rigid internal fixation in bimaxillary osteotomies of the jaws. Twelve patients with a severe skeletal open bite associated with vertical maxillary excess and mandibular deformity were recruited. (Source: International Journal of Oral and Maxillofacial Surgery)

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Prostate Cancer Differentiation and Aggressiveness: Assessment With a Radiomic‐Based Model vs. PI‐RADS v2

Journal of Magnetic Resonance Imaging, EarlyView.


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Prostate Cancer Differentiation and Aggressiveness: Assessment With a Radiomic‐Based Model vs. PI‐RADS v2

Journal of Magnetic Resonance Imaging, EarlyView.


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Characterizing Structural Changes With Devolving Remyelination Following Experimental Demyelination Using High Angular Resolution Diffusion MRI and Texture Analysis

Journal of Magnetic Resonance Imaging, EarlyView.


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Characterizing Structural Changes With Devolving Remyelination Following Experimental Demyelination Using High Angular Resolution Diffusion MRI and Texture Analysis

Journal of Magnetic Resonance Imaging, EarlyView.


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Relationship of Seminal Megavesicles, Prostate Median Cysts, and Genotype in Autosomal Dominant Polycystic Kidney Disease

Journal of Magnetic Resonance Imaging, EarlyView.


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Relationship of Seminal Megavesicles, Prostate Median Cysts, and Genotype in Autosomal Dominant Polycystic Kidney Disease

Journal of Magnetic Resonance Imaging, EarlyView.


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Diffusion Tensor Imaging of the Calf Muscles in Subjects With and Without Diabetes Mellitus

Journal of Magnetic Resonance Imaging, EarlyView.


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Diffusion Tensor Imaging of the Calf Muscles in Subjects With and Without Diabetes Mellitus

Journal of Magnetic Resonance Imaging, EarlyView.


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Radiomics Analysis of Multiparametric MRI Evaluates the Pathological Features of Cervical Squamous Cell Carcinoma

Journal of Magnetic Resonance Imaging, EarlyView.


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Radiomics Analysis of Multiparametric MRI Evaluates the Pathological Features of Cervical Squamous Cell Carcinoma

Journal of Magnetic Resonance Imaging, EarlyView.


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The house dust mite allergen Der p 5 binds lipid ligands and stimulates airway epithelial cells through a TLR2‐dependent pathway

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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The house dust mite allergen Der p 5 binds lipid ligands and stimulates airway epithelial cells through a TLR2‐dependent pathway

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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Multidisciplinary approach to the management of adult eosinophilic oesophagitis in the United Kingdom

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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Multidisciplinary approach to the management of adult eosinophilic oesophagitis in the United Kingdom

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


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A Young Man with Trisomy 21 and Sudden Behavioral Changes

CASE: Grant is a 13-year-old boy with trisomy 21 who presents with his mother for concerns regarding the emergence of several new disruptive behaviors. While he is verbal, he also communicates through an augmentative communication device. He currently attends a residential school. Over the past 2 months, he has begun spitting at the staff, engaging in self-injurious behaviors, placing his hands in his pants and frequently talking about "pee and poop." Notably, Grant has undergone several changes to his educational placement and medical health over the past several months. He recently transferred to his current residential school from another placement to be closer to his family, although this has meant that Grant was unable to work with his long-time aide. Additionally, most of the students at Grant's current school are significantly lower functioning than him, such that Grant is one of the few verbal children. Approximately 3 months ago, Grant underwent significant dental work under anesthesia. Grant had previously taken an alpha-agonist for behavioral management, although this was weaned off 4 months ago due to increasing somnolence. Grant's recent behavioral challenges make performing community and home activities more challenging. Grant's behavioral history is notable for a previous episode of behavioral and emotional challenges 18 months ago. This occurred in the setting of transitioning to a new classroom with higher academic and behavioral expectations and decreased time spent with his family. These behaviors had consisted of self-injurious behaviors and tantrums consisting of crying and social withdrawal. This was managed by increased behavioral and academic supports via trained teachers and aides, medication management, and optimizing his augmentative communication. After these interventions, Grant's behavioral and emotional functioning improved and remained stable until this current episode. Grant's mother is concerned about what may be causing these emerging behaviors and wondering if any of the recent educational and medical stressors could be contributing. What do you do next? Disclosure: The authors declare no conflict of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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A Young Man with Trisomy 21 and Sudden Behavioral Changes

CASE: Grant is a 13-year-old boy with trisomy 21 who presents with his mother for concerns regarding the emergence of several new disruptive behaviors. While he is verbal, he also communicates through an augmentative communication device. He currently attends a residential school. Over the past 2 months, he has begun spitting at the staff, engaging in self-injurious behaviors, placing his hands in his pants and frequently talking about "pee and poop." Notably, Grant has undergone several changes to his educational placement and medical health over the past several months. He recently transferred to his current residential school from another placement to be closer to his family, although this has meant that Grant was unable to work with his long-time aide. Additionally, most of the students at Grant's current school are significantly lower functioning than him, such that Grant is one of the few verbal children. Approximately 3 months ago, Grant underwent significant dental work under anesthesia. Grant had previously taken an alpha-agonist for behavioral management, although this was weaned off 4 months ago due to increasing somnolence. Grant's recent behavioral challenges make performing community and home activities more challenging. Grant's behavioral history is notable for a previous episode of behavioral and emotional challenges 18 months ago. This occurred in the setting of transitioning to a new classroom with higher academic and behavioral expectations and decreased time spent with his family. These behaviors had consisted of self-injurious behaviors and tantrums consisting of crying and social withdrawal. This was managed by increased behavioral and academic supports via trained teachers and aides, medication management, and optimizing his augmentative communication. After these interventions, Grant's behavioral and emotional functioning improved and remained stable until this current episode. Grant's mother is concerned about what may be causing these emerging behaviors and wondering if any of the recent educational and medical stressors could be contributing. What do you do next? Disclosure: The authors declare no conflict of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Gene therapy in mouse models of deafness and balance dysfunction - Wang L, Kempton JB, Brigande JV.

Therapeutic strategies to restore hearing and balance in mouse models of inner ear disease aim to rescue sensory function by gene replacement, augmentation, knock down or knock out. Modalities to achieve therapeutic effects have utilized virus-mediated tra... (Source: SafetyLit)

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Gene therapy in mouse models of deafness and balance dysfunction - Wang L, Kempton JB, Brigande JV.

Therapeutic strategies to restore hearing and balance in mouse models of inner ear disease aim to rescue sensory function by gene replacement, augmentation, knock down or knock out. Modalities to achieve therapeutic effects have utilized virus-mediated tra... (Source: SafetyLit)

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Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad ...

Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad ...  NasdaqFull coverage

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Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad ...

Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad ...  NasdaqFull coverage

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EPA Plan Will Maintain Carbon Emissions From Power Plants

Inadequate regulation of carbon pollution will likely have current, future consequences for human health (Source: The Doctors Lounge - Oncology)

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The anti-inflammatory effect of milk and dairy products on periodontal cells: an in vitro approach

Abstract

Objective

Milk can reduce intestinal tissue damage in colitis models, and protects infants against necrotizing enterocolitis. However, whether milk can decrease inflammation related to peri-implantitis and oral mucosal dehiscence remains unclear. We therefore investigated whether or not milk and fermented by-products have any anti-inflammatory effects on the cells of the oral cavity.

Material and methods

Human gingival fibroblasts and the human oral epithelial cell line HSC2 were exposed to pasteurized human milk, pasteurized cow's milk, dairy products, and powdered milk. An inflammatory response was then provoked with IL1 and TNFα. The expression changes of IL1, IL6, and IL8 were detected by reverse transcriptase PCR and immunoassay.

Results

We can report that pasteurized human milk and pasteurized cow's milk as well as yoghurt, buttermilk, sour milk, whey, and powdered milk can lower the expression of inflammatory cytokines in gingival fibroblasts being stimulated by IL1 and TNFα. A similar anti-inflammatory response to pasteurized milk and dairy products was observed with the human oral epithelial cell line HSC2.

Conclusion

These data suggest that pasteurized and powdered milk, as well as fermented dairy products, display an anti-inflammatory effect on oral fibroblasts and oral epithelial cells.

Clinical relevance

Our in vitro findings provide the scientific basis to extend this research towards testing the anti-inflammatory effects of milk in a pre-clinical periodontitis and peri-implantitis model.

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EPA Plan Will Maintain Carbon Emissions From Power Plants

Inadequate regulation of carbon pollution will likely have current, future consequences for human health (Source: The Doctors Lounge - Oncology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QKWnNR

Evaluation of the relationship between obturation length and presence of apical periodontitis by CBCT: an observational cross-sectional study

Abstract

Objective

The aim of this study was to evaluate the relationship between length of root canal obturation (RCO) and the presence of apical periodontitis (AP) in different dental groups using cone-beam computed tomography (CBCT) analysis.

Materials and methods

A total of 392 roots with canal treatment performed for more than 4 years were evaluated using CBCT. Distances from the apex to the tip of filling material were measured and classified as more than 2 mm short of the apex, approximately 1–2 mm short of the apex, at the apex, and beyond the apex. Odds ratio, confidence interval, and the χ² test were used for statistical analyses.

Results

The frequency of AP was significantly greater in molars than in the other tooth groups (p < 0.05). Moreover, RCO that ended 1–2 mm short of the apex was associated with a lower prevalence of AP in molars and premolars (p < 0.05) and in anterior teeth (p < 0.1) when compared with RCO at the apex, more than 2 mm short of the apex, or beyond the apex. When the RCO reached the apex, there was no difference in the presence of AP among dental groups (p > 0.05).

Conclusion

The length of RCOs can influence the presence of AP, with molars showing a higher prevalence. RCOs ending 1–2 mm short of the apex are associated with an absence of AP.

Clinical relevance

The length of obturation is related to the presence of apical peridontitis and consequently to the success of endodontic treatment.

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