Comparison of Osseointegration between 5 Different Titanium Implant Surfaces

The surface properties of an implant plays the most important role in osseointegration. Titanium dental implants are produced applying different methods such as grit blasting, acid etching, coating, and combination of these techniques yielding materials with roughened surfaces. Those techniques are used to optimize the surface characteristics and to enhance biocompatibility and bioactivity with bone tissue.

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Ultra-Short Implants for Rehabilitation of the Edentulous Posterior Mandible: Outcomes after 2 Years

Rehabilitation of the posterior mandible when limited bone is present is one of the more difficult challenges in implant dentistry. Several techniques have been proposed to vertically augment bone. However, these techniques are unpredictable in the hands of the majority of the clinicians and associated with more trauma and a high incidence of failure. The use of short implants (6-8 mm) has been very well-documented in the literature. Recently, ultra-short implants (4 mm) became available and are 1 more option for rehabilitation of patients with vertical defects in the posterior mandible.

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Comparison of Osseointegration between 5 Different Titanium Implant Surfaces

The surface properties of an implant plays the most important role in osseointegration. Titanium dental implants are produced applying different methods such as grit blasting, acid etching, coating, and combination of these techniques yielding materials with roughened surfaces. Those techniques are used to optimize the surface characteristics and to enhance biocompatibility and bioactivity with bone tissue.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OfobvA

Ultra-Short Implants for Rehabilitation of the Edentulous Posterior Mandible: Outcomes after 2 Years

Rehabilitation of the posterior mandible when limited bone is present is one of the more difficult challenges in implant dentistry. Several techniques have been proposed to vertically augment bone. However, these techniques are unpredictable in the hands of the majority of the clinicians and associated with more trauma and a high incidence of failure. The use of short implants (6-8 mm) has been very well-documented in the literature. Recently, ultra-short implants (4 mm) became available and are 1 more option for rehabilitation of patients with vertical defects in the posterior mandible.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2In0cFq

Chronotolerance for cisplatin ototoxicity in the rat.

The objective of the study was to determine the sensitivity of cisplatin ototoxicity to circadian time. Fifty-seven Fischer 344/NHsd rats were exposed to 12 mg/kg cisplatin by intra-peritoneal injection at one of six time points on a 12 h light-12 h dark cycle: 2, 6, or 10 h after light onset or 2, 6, or 10 h after light offset. Cochlear injury was evaluated using auditory brainstem response threshold shifts and postmortem outer hair cell counts. All animals experienced threshold shift in the highest frequencies tested (30 and 40 kHz). The animals exposed to cisplatin at 6 h after light onset (the inactive period) had significantly higher mid-frequency threshold shifts and outer hair cell losses than the groups exposed during the dark hours. The results indicate that cisplati...

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Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea.

Authors: Altschuler RA, Kanicki A, Martin C, Kohrman DC, Miller RA Abstract Adding rapamycin or acarbose to diet at 9-10 months of age has been shown to significantly increase life span in both male and female UM-HET3 mice. The current study examined cochleae of male and female UM-HET3 mice at 22 months of age to determine if either treatment also influenced age-related loss of cochlear hair cells. A large loss of cochlear outer hair cells was observed at 22 months of age in untreated mice in both apical and basal halves of the cochlear spiral. Addition of acarbose to diet had no significant effect on the amount of outer hair cell loss at 22 months of age or in its pattern, with large loss in both apical and basal halves. The addition of rapamycin to diet, however, significantly re...

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Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea.

Authors: Altschuler RA, Kanicki A, Martin C, Kohrman DC, Miller RA Abstract Adding rapamycin or acarbose to diet at 9-10 months of age has been shown to significantly increase life span in both male and female UM-HET3 mice. The current study examined cochleae of male and female UM-HET3 mice at 22 months of age to determine if either treatment also influenced age-related loss of cochlear hair cells. A large loss of cochlear outer hair cells was observed at 22 months of age in untreated mice in both apical and basal halves of the cochlear spiral. Addition of acarbose to diet had no significant effect on the amount of outer hair cell loss at 22 months of age or in its pattern, with large loss in both apical and basal halves. The addition of rapamycin to diet, however, significantly re...

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White matter involvement in young non-demented Down’s syndrome subjects: a tract-based spatial statistic analysis

Abstract

Purpose

Cognitive decline in Down syndrome generally shows neurodegenerative aspects similar to what is observed in Alzheimer's disease. Few studies reported information on white matter integrity. The aim of this study was to evaluate white matter alterations in a cohort of young Down subjects, without dementia, by means of DTI technique, compared to a normal control group.

Methods

The study group consisted of 17 right-handed subjects with DS and many control subjects. All individuals participating in this study were examined by MR exam including DTI acquisition (32 non-coplanar directions); image processing and analysis were performed using FMRIB Software Library (FSL version 4.1.9, http://www.fmrib.ox.ac.uk/fsl)) software package. Finally, the diffusion tensor was estimated voxel by voxel and the FA map derived from the tensor. A two-sample t test was performed to assess differences between DS and control subjects.

Results

The FA is decreased in DS subjects, compared to control subjects, in the region of the anterior thalamic radiation, the inferior fronto-occipital fasciculum, the inferior longitudinal fasciculum, and the cortico-spinal tract, bilaterally.

Conclusions

The early white matter damage visible in our DS subjects could have great impact in the therapeutic management, in particular in better adapting the timing of therapies to counteract the toxic effect of the deposition of amyloid that leads to oxidative stress.

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White matter involvement in young non-demented Down’s syndrome subjects: a tract-based spatial statistic analysis

Abstract

Purpose

Cognitive decline in Down syndrome generally shows neurodegenerative aspects similar to what is observed in Alzheimer's disease. Few studies reported information on white matter integrity. The aim of this study was to evaluate white matter alterations in a cohort of young Down subjects, without dementia, by means of DTI technique, compared to a normal control group.

Methods

The study group consisted of 17 right-handed subjects with DS and many control subjects. All individuals participating in this study were examined by MR exam including DTI acquisition (32 non-coplanar directions); image processing and analysis were performed using FMRIB Software Library (FSL version 4.1.9, http://www.fmrib.ox.ac.uk/fsl)) software package. Finally, the diffusion tensor was estimated voxel by voxel and the FA map derived from the tensor. A two-sample t test was performed to assess differences between DS and control subjects.

Results

The FA is decreased in DS subjects, compared to control subjects, in the region of the anterior thalamic radiation, the inferior fronto-occipital fasciculum, the inferior longitudinal fasciculum, and the cortico-spinal tract, bilaterally.

Conclusions

The early white matter damage visible in our DS subjects could have great impact in the therapeutic management, in particular in better adapting the timing of therapies to counteract the toxic effect of the deposition of amyloid that leads to oxidative stress.

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Resection of Inverted Papilloma of the Maxillary Sinus via a Prelacrimal Recess Approach: A Multicenter Retrospective Analysis of Surgical Efficacy.

Conclusions These multicenter follow-up results demonstrated that the PLRA is a safe and effective method for the excision of primary or recurrent IPMS with lower postoperative complications and recurrent rate. PMID: 30251558 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)

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Resection of Inverted Papilloma of the Maxillary Sinus via a Prelacrimal Recess Approach: A Multicenter Retrospective Analysis of Surgical Efficacy.

Conclusions These multicenter follow-up results demonstrated that the PLRA is a safe and effective method for the excision of primary or recurrent IPMS with lower postoperative complications and recurrent rate. PMID: 30251558 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)

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Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis.

Conclusion Just as SAgs are known to feature in many allergic conditions, they play their part in AR, chronic rhinosinusitis, asthma, and AD. Further research is required before the relationship between SAgs and allergy can be adequately explained. PMID: 30253652 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)

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Narrating the journey of sustained recovery from substance use disorder

The reported high rate of relapse in the context of an ever-increasing rate of substance abuse internationally and in South Africa together with the fact that the topic of sustained recovery from Substance Use...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IlEG3D

Narrating the journey of sustained recovery from substance use disorder

The reported high rate of relapse in the context of an ever-increasing rate of substance abuse internationally and in South Africa together with the fact that the topic of sustained recovery from Substance Use...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IlEG3D

Procedural sedation: a position paper of the Canadian Anesthesiologists’ Society

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Procedural sedation: a position paper of the Canadian Anesthesiologists’ Society

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Odontogenic Maxillofacial Space Infections: A 5-Year Retrospective Review in Navi Mumbai

Abstract

Purpose

The aim of this study is to comprehensively review and analyse pure odontogenic maxillofacial space infections in a tertiary care hospital in Navi Mumbai over a period of 5 years.

Methods

A retrospective analysis of 315 patients treated at Dr. D. Y. Patil Dental College and Hospital at Nerul, Navi Mumbai, from January 2007 to December 2011 was done. Multiple variables were analysed. Localised infections like dentoalveolar infections without space involvement and infection of non-odontogenic cause were excluded from the study.

Results

Analysis of the records was done. Majority of patients were from lower socioeconomic background and were daily wage workers who had either consulted a general physician or a general dental practitioner or had self-medicated themselves before presenting to us with acute symptoms. Early recognition and prompt treatment involving intravenous antibiotics with extraction of involved tooth/teeth and incision and drainage helped in resolution of infections in a span of 72 h. Medically compromised patients had longer duration of hospital stay as compared to the patients who had no underlying medical condition. Majority of space infections involved multiple spaces and local anaesthesia with sedation was found to be the satisfactory mode of anaesthesia. Complications were very few.

Conclusion

We concurred that any form of odontogenic maxillofacial space infection should be rendered prompt and aggressive treatment and hospitalisation should be recommended wherever required.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUjS5O

Odontogenic Maxillofacial Space Infections: A 5-Year Retrospective Review in Navi Mumbai

Abstract

Purpose

The aim of this study is to comprehensively review and analyse pure odontogenic maxillofacial space infections in a tertiary care hospital in Navi Mumbai over a period of 5 years.

Methods

A retrospective analysis of 315 patients treated at Dr. D. Y. Patil Dental College and Hospital at Nerul, Navi Mumbai, from January 2007 to December 2011 was done. Multiple variables were analysed. Localised infections like dentoalveolar infections without space involvement and infection of non-odontogenic cause were excluded from the study.

Results

Analysis of the records was done. Majority of patients were from lower socioeconomic background and were daily wage workers who had either consulted a general physician or a general dental practitioner or had self-medicated themselves before presenting to us with acute symptoms. Early recognition and prompt treatment involving intravenous antibiotics with extraction of involved tooth/teeth and incision and drainage helped in resolution of infections in a span of 72 h. Medically compromised patients had longer duration of hospital stay as compared to the patients who had no underlying medical condition. Majority of space infections involved multiple spaces and local anaesthesia with sedation was found to be the satisfactory mode of anaesthesia. Complications were very few.

Conclusion

We concurred that any form of odontogenic maxillofacial space infection should be rendered prompt and aggressive treatment and hospitalisation should be recommended wherever required.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUjS5O

Interaural Time Difference Perception with a Cochlear Implant and a Normal Ear

Abstract

Currently there is a growing population of cochlear-implant (CI) users with (near) normal hearing in the non-implanted ear. This configuration is often called SSD (single-sided deafness) CI. The goal of the CI is often to improve spatial perception, so the question raises to what extent SSD CI listeners are sensitive to interaural time differences (ITDs). In a controlled lab setup, sensitivity to ITDs was investigated in 11 SSD CI listeners. The stimuli were 100-pps pulse trains on the CI side and band-limited click trains on the acoustic side. After determining level balance and the delay needed to achieve synchronous stimulation of the two ears, the just noticeable difference in ITD was measured using an adaptive procedure. Seven out of 11 listeners were sensitive to ITDs, with a median just noticeable difference of 438 μs. Out of the four listeners who were not sensitive to ITD, one listener reported binaural fusion, and three listeners reported no binaural fusion. To enable ITD sensitivity, a frequency-dependent delay of the electrical stimulus was required to synchronize the electric and acoustic signals at the level of the auditory nerve. Using subjective fusion measures and refined by ITD sensitivity, it was possible to match a CI electrode to an acoustic frequency range. This shows the feasibility of these measures for the allocation of acoustic frequency ranges to electrodes when fitting a CI to a subject with (near) normal hearing in the contralateral ear.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2N6Jvid

Interaural Time Difference Perception with a Cochlear Implant and a Normal Ear

Abstract

Currently there is a growing population of cochlear-implant (CI) users with (near) normal hearing in the non-implanted ear. This configuration is often called SSD (single-sided deafness) CI. The goal of the CI is often to improve spatial perception, so the question raises to what extent SSD CI listeners are sensitive to interaural time differences (ITDs). In a controlled lab setup, sensitivity to ITDs was investigated in 11 SSD CI listeners. The stimuli were 100-pps pulse trains on the CI side and band-limited click trains on the acoustic side. After determining level balance and the delay needed to achieve synchronous stimulation of the two ears, the just noticeable difference in ITD was measured using an adaptive procedure. Seven out of 11 listeners were sensitive to ITDs, with a median just noticeable difference of 438 μs. Out of the four listeners who were not sensitive to ITD, one listener reported binaural fusion, and three listeners reported no binaural fusion. To enable ITD sensitivity, a frequency-dependent delay of the electrical stimulus was required to synchronize the electric and acoustic signals at the level of the auditory nerve. Using subjective fusion measures and refined by ITD sensitivity, it was possible to match a CI electrode to an acoustic frequency range. This shows the feasibility of these measures for the allocation of acoustic frequency ranges to electrodes when fitting a CI to a subject with (near) normal hearing in the contralateral ear.

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Editorial Board

Publication date: October 2018

Source: Hearing Research, Volume 368

Author(s):

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Editorial Board

Publication date: October 2018

Source: Hearing Research, Volume 368

Author(s):

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UVA-induced neurotoxicity in Japanese medaka (Oryzias latipes)

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00169C, Paper

Alaa El-Din Hamid Sayed, Hamdy Soliman, Hiroshi Mitani
Ultraviolet radiation-induced neurodegeneration has been studied in early stages of fish species, but not extensively in adult stage of fish. The present study aimed to investigate the effects of ultraviolet...
The content of this RSS Feed (c) The Royal Society of Chemistry

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UVA-induced neurotoxicity in Japanese medaka (Oryzias latipes)

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00169C, Paper

Alaa El-Din Hamid Sayed, Hamdy Soliman, Hiroshi Mitani
Ultraviolet radiation-induced neurodegeneration has been studied in early stages of fish species, but not extensively in adult stage of fish. The present study aimed to investigate the effects of ultraviolet...
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Oh7Zd5

Risk Factors Associated With Unplanned Reoperation in Major Head and Neck Surgery

This cohort study uses the American College of Surgeons National Surgical Quality Improvement Program 2005-2014 database to identify risk factors associated with unplanned reoperation following major head and neck surgical procedures.

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Risk Factors Associated With Unplanned Reoperation in Major Head and Neck Surgery

This cohort study uses the American College of Surgeons National Surgical Quality Improvement Program 2005-2014 database to identify risk factors associated with unplanned reoperation following major head and neck surgical procedures.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xE1p72

Rapidly Enlarging Parapharyngeal Mass

A man in his 40s with Poland syndrome presented with 6-month history of left throat pain and enlarging oropharyngeal mass. What is your diagnosis?

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Rapidly Enlarging Parapharyngeal Mass

A man in his 40s with Poland syndrome presented with 6-month history of left throat pain and enlarging oropharyngeal mass. What is your diagnosis?

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Patient Concerns About Nasal Reconstruction and Implications for Shared Decision Making

This study examines the concerns of patients with nonmelanoma skin cancer regarding nasal reconstruction after Mohs surgery to develop an intervention to improve the shared decision-making process of patients and practitioners.

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Patient Concerns About Nasal Reconstruction and Implications for Shared Decision Making

This study examines the concerns of patients with nonmelanoma skin cancer regarding nasal reconstruction after Mohs surgery to develop an intervention to improve the shared decision-making process of patients and practitioners.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xE1oQw

Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss

This systematic review and meta-analysis of 19 studies evaluates the benefit of the addition of hyperbaric oxygen therapy for patients with sudden sensorineural hearing loss.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUKhR8

Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss

This systematic review and meta-analysis of 19 studies evaluates the benefit of the addition of hyperbaric oxygen therapy for patients with sudden sensorineural hearing loss.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUKhR8

Standard Clinical Method vs Patient-Centered Tinnitus Likeness Rating

This case series assessed individual test-retest reliability of the 2-alternative forced-choice and tinnitus likeness rating approaches in patients undergoing evaluation for tinnitus.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xGIQ2f

Standard Clinical Method vs Patient-Centered Tinnitus Likeness Rating

This case series assessed individual test-retest reliability of the 2-alternative forced-choice and tinnitus likeness rating approaches in patients undergoing evaluation for tinnitus.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xGIQ2f

Odontogenic Maxillofacial Space Infections: A 5-Year Retrospective Review in Navi Mumbai

Abstract

Purpose

The aim of this study is to comprehensively review and analyse pure odontogenic maxillofacial space infections in a tertiary care hospital in Navi Mumbai over a period of 5 years.

Methods

A retrospective analysis of 315 patients treated at Dr. D. Y. Patil Dental College and Hospital at Nerul, Navi Mumbai, from January 2007 to December 2011 was done. Multiple variables were analysed. Localised infections like dentoalveolar infections without space involvement and infection of non-odontogenic cause were excluded from the study.

Results

Analysis of the records was done. Majority of patients were from lower socioeconomic background and were daily wage workers who had either consulted a general physician or a general dental practitioner or had self-medicated themselves before presenting to us with acute symptoms. Early recognition and prompt treatment involving intravenous antibiotics with extraction of involved tooth/teeth and incision and drainage helped in resolution of infections in a span of 72 h. Medically compromised patients had longer duration of hospital stay as compared to the patients who had no underlying medical condition. Majority of space infections involved multiple spaces and local anaesthesia with sedation was found to be the satisfactory mode of anaesthesia. Complications were very few.

Conclusion

We concurred that any form of odontogenic maxillofacial space infection should be rendered prompt and aggressive treatment and hospitalisation should be recommended wherever required.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUjS5O

Odontogenic Maxillofacial Space Infections: A 5-Year Retrospective Review in Navi Mumbai

Abstract

Purpose

The aim of this study is to comprehensively review and analyse pure odontogenic maxillofacial space infections in a tertiary care hospital in Navi Mumbai over a period of 5 years.

Methods

A retrospective analysis of 315 patients treated at Dr. D. Y. Patil Dental College and Hospital at Nerul, Navi Mumbai, from January 2007 to December 2011 was done. Multiple variables were analysed. Localised infections like dentoalveolar infections without space involvement and infection of non-odontogenic cause were excluded from the study.

Results

Analysis of the records was done. Majority of patients were from lower socioeconomic background and were daily wage workers who had either consulted a general physician or a general dental practitioner or had self-medicated themselves before presenting to us with acute symptoms. Early recognition and prompt treatment involving intravenous antibiotics with extraction of involved tooth/teeth and incision and drainage helped in resolution of infections in a span of 72 h. Medically compromised patients had longer duration of hospital stay as compared to the patients who had no underlying medical condition. Majority of space infections involved multiple spaces and local anaesthesia with sedation was found to be the satisfactory mode of anaesthesia. Complications were very few.

Conclusion

We concurred that any form of odontogenic maxillofacial space infection should be rendered prompt and aggressive treatment and hospitalisation should be recommended wherever required.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUjS5O

Interaural Time Difference Perception with a Cochlear Implant and a Normal Ear

Abstract

Currently there is a growing population of cochlear-implant (CI) users with (near) normal hearing in the non-implanted ear. This configuration is often called SSD (single-sided deafness) CI. The goal of the CI is often to improve spatial perception, so the question raises to what extent SSD CI listeners are sensitive to interaural time differences (ITDs). In a controlled lab setup, sensitivity to ITDs was investigated in 11 SSD CI listeners. The stimuli were 100-pps pulse trains on the CI side and band-limited click trains on the acoustic side. After determining level balance and the delay needed to achieve synchronous stimulation of the two ears, the just noticeable difference in ITD was measured using an adaptive procedure. Seven out of 11 listeners were sensitive to ITDs, with a median just noticeable difference of 438 μs. Out of the four listeners who were not sensitive to ITD, one listener reported binaural fusion, and three listeners reported no binaural fusion. To enable ITD sensitivity, a frequency-dependent delay of the electrical stimulus was required to synchronize the electric and acoustic signals at the level of the auditory nerve. Using subjective fusion measures and refined by ITD sensitivity, it was possible to match a CI electrode to an acoustic frequency range. This shows the feasibility of these measures for the allocation of acoustic frequency ranges to electrodes when fitting a CI to a subject with (near) normal hearing in the contralateral ear.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2N6Jvid

Interaural Time Difference Perception with a Cochlear Implant and a Normal Ear

Abstract

Currently there is a growing population of cochlear-implant (CI) users with (near) normal hearing in the non-implanted ear. This configuration is often called SSD (single-sided deafness) CI. The goal of the CI is often to improve spatial perception, so the question raises to what extent SSD CI listeners are sensitive to interaural time differences (ITDs). In a controlled lab setup, sensitivity to ITDs was investigated in 11 SSD CI listeners. The stimuli were 100-pps pulse trains on the CI side and band-limited click trains on the acoustic side. After determining level balance and the delay needed to achieve synchronous stimulation of the two ears, the just noticeable difference in ITD was measured using an adaptive procedure. Seven out of 11 listeners were sensitive to ITDs, with a median just noticeable difference of 438 μs. Out of the four listeners who were not sensitive to ITD, one listener reported binaural fusion, and three listeners reported no binaural fusion. To enable ITD sensitivity, a frequency-dependent delay of the electrical stimulus was required to synchronize the electric and acoustic signals at the level of the auditory nerve. Using subjective fusion measures and refined by ITD sensitivity, it was possible to match a CI electrode to an acoustic frequency range. This shows the feasibility of these measures for the allocation of acoustic frequency ranges to electrodes when fitting a CI to a subject with (near) normal hearing in the contralateral ear.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2N6Jvid

Induced Polyethylene Glycol Fusion in Rat Facial Nerves?

To the Editor In their recent article, Brown et al^(E7) conclude that "polyethylene glycol fusion has shown efficacy in the surgical repair of spinal nerve injuries, but this finding was not replicated in facial nerve injury repair." Problematically, Brown et al almost certainly did not induce polyethylene glycol (PEG)-mediated fusion repair of facial nerves in rats. We come to this conclusion for the following 3 reasons:

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Association of Skin and Cartilage Variables With Composite Graft Healing in a Rabbit Model

This animal model study investigates the ideal ratio of skin to cartilage and studies the importance of the perichondrial attachment for graft survival.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OfBc8o

Superiorly Pediculated Superficial Musculoaponeurotic System Ligament Flap

This Surgical Pearl presents the technique for the superiorly pediculated SMAS ligament flap to hide nasal tip irregularities at the end of rhinoplasty.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2N6XhBo

Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma

Abstract

Background

To investigate the effect of DACH1 over-expression on proliferation and invasion of laryngeal squamous cell carcinoma (LSCC).

Methods

The 120 cases of LSCC tumors and 114 adjacent non-neoplastic tissues were collected to detect the expression of DACH1 by immunohistochemistry. The changes of DACH1 expression from each group were assessed and correlated to the clinical parameters of the patients. Plasmid-DACH1 was transfected into Hep-2 cells to up-regulate the expression of DACH1C. Real-time PCR, Western blot, CCK8 and transwell assay were used to verify the cell proliferation and invasion after plasmid-DACH1 transfection.

Results

The results indicated that DACH1 was downregulated in LSCC tissues as compared to corresponding adjacent non-neoplastic tissues. Decreased expression of DACH1 was found in the tumors upraglottic tumor, lymph node metastases, T3–4 stage and advanced clinical stage. In Hep-2 cells, transfection with plasmid-DACH1 could suppress cell proliferation, invasion and induce G1 phase extension in cell cycle.

Conclusions

DACH1 may act as a tumor suppressor gene and could be a potential target for therapeutic intervention of LSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xJXndl

Induced Polyethylene Glycol Fusion in Rat Facial Nerves?

To the Editor In their recent article, Brown et al^(E7) conclude that "polyethylene glycol fusion has shown efficacy in the surgical repair of spinal nerve injuries, but this finding was not replicated in facial nerve injury repair." Problematically, Brown et al almost certainly did not induce polyethylene glycol (PEG)-mediated fusion repair of facial nerves in rats. We come to this conclusion for the following 3 reasons:

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2N6eTND

Association of Skin and Cartilage Variables With Composite Graft Healing in a Rabbit Model

This animal model study investigates the ideal ratio of skin to cartilage and studies the importance of the perichondrial attachment for graft survival.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OfBc8o

Superiorly Pediculated Superficial Musculoaponeurotic System Ligament Flap

This Surgical Pearl presents the technique for the superiorly pediculated SMAS ligament flap to hide nasal tip irregularities at the end of rhinoplasty.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2N6XhBo

Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma

Abstract

Background

To investigate the effect of DACH1 over-expression on proliferation and invasion of laryngeal squamous cell carcinoma (LSCC).

Methods

The 120 cases of LSCC tumors and 114 adjacent non-neoplastic tissues were collected to detect the expression of DACH1 by immunohistochemistry. The changes of DACH1 expression from each group were assessed and correlated to the clinical parameters of the patients. Plasmid-DACH1 was transfected into Hep-2 cells to up-regulate the expression of DACH1C. Real-time PCR, Western blot, CCK8 and transwell assay were used to verify the cell proliferation and invasion after plasmid-DACH1 transfection.

Results

The results indicated that DACH1 was downregulated in LSCC tissues as compared to corresponding adjacent non-neoplastic tissues. Decreased expression of DACH1 was found in the tumors upraglottic tumor, lymph node metastases, T3–4 stage and advanced clinical stage. In Hep-2 cells, transfection with plasmid-DACH1 could suppress cell proliferation, invasion and induce G1 phase extension in cell cycle.

Conclusions

DACH1 may act as a tumor suppressor gene and could be a potential target for therapeutic intervention of LSCC.

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Regional anaesthesia in patients taking anticoagulant drugs

Publication date: Available online 27 September 2018

Source: Anaesthesia & Intensive Care Medicine

Author(s): Matthew R. Checketts

Abstract

Many surgical patients are taking drugs that impair normal coagulation, and this causes concern about the risk of perioperative bleeding events. The anaesthetist is particularly concerned about compressive vertebral canal haematomas that may occur after spinal or epidural anaesthetic techniques. Fortunately, the risk of this complication is very low. The major risk factors are coagulopathy or technical difficulties with the block. There is also concern about perineural haematomas that may be associated with peripheral nerve blocks. This article attempts to put the risks of these complications into context, with reference to different classes of anticoagulant drugs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xHUSZ7

Regional anaesthesia in patients taking anticoagulant drugs

Publication date: Available online 27 September 2018

Source: Anaesthesia & Intensive Care Medicine

Author(s): Matthew R. Checketts

Abstract

Many surgical patients are taking drugs that impair normal coagulation, and this causes concern about the risk of perioperative bleeding events. The anaesthetist is particularly concerned about compressive vertebral canal haematomas that may occur after spinal or epidural anaesthetic techniques. Fortunately, the risk of this complication is very low. The major risk factors are coagulopathy or technical difficulties with the block. There is also concern about perineural haematomas that may be associated with peripheral nerve blocks. This article attempts to put the risks of these complications into context, with reference to different classes of anticoagulant drugs.

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Techniques of epidural block

Publication date: Available online 27 September 2018

Source: Anaesthesia & Intensive Care Medicine

Author(s): Willie McClymont, Dan Celnick

Abstract

Epidural blocks are used for relief of chronic pain, labour pain and postoperative pain as well as for surgical anaesthesia. Effect can be targeted at the insertion level which can be from cervical spine level all the way to the sacral hiatus in the case of a caudal epidural block. Catheter insertion means doses can be repeated and the effect maintained. This contrasts with the typical single-shot spinal/subarachnoid injection primarily used for surgical anaesthesia. Specifically avoiding dural puncture also contrasts with the spinal's simple endpoint of detecting CSF. Accurate epidural needle insertion is therefore technically more difficult. The variety of methods available to identify if the needle tip is in the epidural space highlights this much less certain endpoint. With epidural injections, drug solutions need to physically spread to access each intended nerve root. This makes epidurals less reliable than spinals, where simply depositing the solution in the CSF rapidly enables it to bathe all the nerve roots encountered. Serious risks such as direct damage to nerve tissue, infection and epidural haematoma are shared with spinal anaesthesia but may be more likely with epidural techniques. Epidural needles are wider bore and more likely to damage tissue and vessels. They are sometimes directed close to the spinal cord itself. In-dwelling catheters can move and traumatize vessels and act as a focus for infection. Despite these potential drawbacks, careful selection, skilled placement and management mean patients can safely derive the intended benefits and epidurals and caudal blocks continue to be popular.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2N5Xsgg

Techniques of epidural block

Publication date: Available online 27 September 2018

Source: Anaesthesia & Intensive Care Medicine

Author(s): Willie McClymont, Dan Celnick

Abstract

Epidural blocks are used for relief of chronic pain, labour pain and postoperative pain as well as for surgical anaesthesia. Effect can be targeted at the insertion level which can be from cervical spine level all the way to the sacral hiatus in the case of a caudal epidural block. Catheter insertion means doses can be repeated and the effect maintained. This contrasts with the typical single-shot spinal/subarachnoid injection primarily used for surgical anaesthesia. Specifically avoiding dural puncture also contrasts with the spinal's simple endpoint of detecting CSF. Accurate epidural needle insertion is therefore technically more difficult. The variety of methods available to identify if the needle tip is in the epidural space highlights this much less certain endpoint. With epidural injections, drug solutions need to physically spread to access each intended nerve root. This makes epidurals less reliable than spinals, where simply depositing the solution in the CSF rapidly enables it to bathe all the nerve roots encountered. Serious risks such as direct damage to nerve tissue, infection and epidural haematoma are shared with spinal anaesthesia but may be more likely with epidural techniques. Epidural needles are wider bore and more likely to damage tissue and vessels. They are sometimes directed close to the spinal cord itself. In-dwelling catheters can move and traumatize vessels and act as a focus for infection. Despite these potential drawbacks, careful selection, skilled placement and management mean patients can safely derive the intended benefits and epidurals and caudal blocks continue to be popular.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2N5Xsgg

Odontogenic Myxoma: a 63-Year Retrospective Multicentric Study and an Analysis of 999 Cases Reported in Literature

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Felipe Martins Silveira, Ricardo Alves Mesquita, Ana Paula Veras Sobral, Leorik Pereira Da Silva, Filipe Jaeger, Ana Carolina Uchoa Vasconcelos

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUtei3

Screening for Oral Cancer for Primary Health Care in a Rural Area in Northeast Brazil

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Allan Vinícius Martins De Barros, Ana Maria Ipólito Barros, Fábio Andrey Da Costa Araújo, Fernando Flávio Souza Vaz, Stefânia Jeronimo Ferreira, Marianne De Vasconcelos Carvalho

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R1tSM5

Oral Manifestations in Hospitalized Individuals with Hematological Disease

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Adrianna Milagres, Fernanda Guimarães De Azevedo Pereira, Marina Cortês Vieira, Joyce Barbosa, Carlos Henrique Costa Baptista De Mello, Karin Soares Gonçalves Cunha, Arley Silva Júnior

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ORvbvH

Prevalence of Oral Lymphoid Lesions Diagnosed at A Pathological Anatomy Service Over A Period of 46 Years

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Rafaella Bastos Leite, Juliana Campos Pinheiro, Caio César Da Silva Barros, Larissa Santos Amaral Rolim, Leão Pereira Pinto, Lélia Batista De Souza, Pedro Paulo De Andrade Santos

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R4pFXV

Diagnosis of Oral Cancer in Oncology Clinical Practice

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Aline Dos Santos Queiroz De Almeida, Itamar Araujo Bessa, Edna Aparecida Miras, Natalia Shizu Kusuke, Carlos Deyver De Souza Queiroz

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ORv0Ax

Characteristics and Outcomes of Head and Neck Cancer in Females and Young Adults

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Willene Dos Santos Machado Zorzaneli, Jéssica Graça Sant Anna, Priscila Marinho De Abreu, Isabela Bittencourt Do Valle, Vinicius Mendes Eduardo, José Roberto Vasconcelos De Podestá, Sandra Ventorin Von Zeidler

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Epidemiologic Study of Odontogenic and Non-Odontogenic Cysts in Children and Adolescents of a Brazilian Population

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Dáurea Adília Cóbe Sena, Leorik Pereira Da Silva, Caio César Da Silva Barros, Mara Luana Batista Severo, Amanda Katarinny Goes Gonzaga, Lélia Batista De Souza, Éricka Janine Dantas Da Silveira

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ORuORP

Root Dilaceration: Radiographic Analysis in Patients with Nonsyndromic Cleft Lip and/or Palate

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Laís Bastos Guimarães, Gabriela Dos Santos Lopes, Iêda Margarida Crusoé Rebello, Deborah Queiroz De Freitas, Ricardo Della Coletta, Patrícia De Castro Veiga, Silvia Regina De Almeida Reis

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R39HNZ

Ulcerated Lesions in the Oral Mucosa as Manifestations of Arboviruses: a Series of Cases

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Ana Maria Ipólito Barros, Allan Vinícius Martins De Barros, Clarisbalte Martins Sampaio Sá Bezerra, Eudes Euler De Souza Lucena, Samylla Glória De Araújo Costa, Tainara Tejada Camacho, Fábio Andrey Da Costa Araújo

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OTfRi5

Common Oral Lesions in Hospitalized Patients and Physicians' Opinion About the Role of A Dentist in the Hospital

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Paula Sena Da Mata, Claudia Yumi Maeda, Desiree Rosa Cavalcanti, Marcelo Marcucci, Debora Cristina Gonçalves Blanco, Fabiano Vasconcelos

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R4pf3N

In Vitro Investigation of the Antifungal Potential of Pyroligneous Acid

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Lara Moreira Jalles Milani, Rafael Guerra Lund, Rodrigo Galo, Simone Gomes Dias De Oliveira

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OTfHHv

CLIC4 and CLIC4-Associated Proteins in Actinic Cheilitis and Squamous Cell Carcinoma of the Lower Lip

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Maria Luiza Diniz De Sousa Lopes, Francisco Jadson Lima, Márcia Cristina Da Costa Miguel, Lélia Maria Guedes Queiroz, Cassiano Francisco Weege Nonaka, Éricka Janine Dantas Da Silveira

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QZ1ASq

Clinical Profile of Oral Mucosal Lesions in Elderly Patients: A 20-Year Retrospective Study

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Andreia Bufalino, Ana Thais Bagatini, Túlio Morandin Ferrisse, Mariel Ruivo Biancardi, Cláudia Maria Navarro, Elaine Maria Sgavioli Massucato, Darcy Fernandes

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVWCo2

Oral Cancer: Epidemiological Survey of Patients at A Porto Alegre Reference Hospital – Rs/Brazil

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Maria Eduarda L. Baldino, Karen Loureiro Weigert, Francine K.R. Soares

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R27BOh

Psychological Factors as the Main Motivators for Tobacco Use According to the Patients' Own Perception

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Vitor Bonetti Valente, Bruna Amélia Moreira Sarafim Da Silva, Clícia Keiko Sakamoto Nishida, Edilze Fatima Gardenal Fani, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Daniel Galera Bernabé

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVWwga

Retrospective Study of the Oral Cavity Injuries at the Dental Urgency Sector Referenced to the Clinical Stomatology

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): João Pedro Mota Cardoso Almeida Ribeiro, Thainá Fonseca Strina, Sibele Sarti Penha, Irene Graça Azevedo Pina Vaz, Carina Domaneschi

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QYlkWt

Actinic Cheilits: Epidemiological Study in Farmers From Pernambuco, Brazil

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Stefânia Jeronimo Ferreira, Izabelly Germinia Gomes De Melo, Fernando Flávio Souza Vaz, Jardel Jorge Santos, Allan Vinícius Martins De Barros, Eduardo Sérgio Donato Duarte Filho, Marianne De Vasconcelos Carvalho

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUiQHc

Prognostic Activity of Cyclin D1 in Oral Squamous Cell Carcinoma

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Isabella Bittencourt Do Valle, Thabata Coeli Dias Damasceno, Paola Fernandes Pansini, Willene Dos Santos Machado Zolzaneli, Danielle Resende Camisasca, Hisham Mehanna, Sandra Ventorin Von Zeidler

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R2twEW

Evaluation of Resting and Stimulated Sialometry Techniques in Patients with Rheumatoid Arthritis

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Érica Passos De Medeiros Lacerda, Isabela Izidoro Ramos, Larissa Santos Fernandes, Sarah Raquel Cavalcanti Bezerra Melo, Alessandra De A.T. Carvalho, Jair Carneiro Leão, Luiz Alcino Gueiros

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVg7NN

Survey of Oral and Maxillofacial Pathology Specimens Submitted by Dental Practitioners: A Study Over A 15-Year Period

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): José Erivaldo Da Silva Mendes, Augusto César Leal Da Silva Leonel, Carla Isabelly Rodrigues Fernandes, Kamilla Karla Maurício Passos, Elaine Judite De Amorim Carvalho, Jurema Freire Lisboa De Castro, Danyel Elias Da Cruz Perez

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R1tHQV

Odontogenic Myxoma: a 63-Year Retrospective Multicentric Study and an Analysis of 999 Cases Reported in Literature

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Felipe Martins Silveira, Ricardo Alves Mesquita, Ana Paula Veras Sobral, Leorik Pereira Da Silva, Filipe Jaeger, Ana Carolina Uchoa Vasconcelos

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUtei3

Screening for Oral Cancer for Primary Health Care in a Rural Area in Northeast Brazil

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Allan Vinícius Martins De Barros, Ana Maria Ipólito Barros, Fábio Andrey Da Costa Araújo, Fernando Flávio Souza Vaz, Stefânia Jeronimo Ferreira, Marianne De Vasconcelos Carvalho

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R1tSM5

Oral Manifestations in Hospitalized Individuals with Hematological Disease

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Adrianna Milagres, Fernanda Guimarães De Azevedo Pereira, Marina Cortês Vieira, Joyce Barbosa, Carlos Henrique Costa Baptista De Mello, Karin Soares Gonçalves Cunha, Arley Silva Júnior

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ORvbvH

Prevalence of Oral Lymphoid Lesions Diagnosed at A Pathological Anatomy Service Over A Period of 46 Years

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Rafaella Bastos Leite, Juliana Campos Pinheiro, Caio César Da Silva Barros, Larissa Santos Amaral Rolim, Leão Pereira Pinto, Lélia Batista De Souza, Pedro Paulo De Andrade Santos

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R4pFXV

Diagnosis of Oral Cancer in Oncology Clinical Practice

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Aline Dos Santos Queiroz De Almeida, Itamar Araujo Bessa, Edna Aparecida Miras, Natalia Shizu Kusuke, Carlos Deyver De Souza Queiroz

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ORv0Ax

Characteristics and Outcomes of Head and Neck Cancer in Females and Young Adults

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Willene Dos Santos Machado Zorzaneli, Jéssica Graça Sant Anna, Priscila Marinho De Abreu, Isabela Bittencourt Do Valle, Vinicius Mendes Eduardo, José Roberto Vasconcelos De Podestá, Sandra Ventorin Von Zeidler

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R4pufd

Epidemiologic Study of Odontogenic and Non-Odontogenic Cysts in Children and Adolescents of a Brazilian Population

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Dáurea Adília Cóbe Sena, Leorik Pereira Da Silva, Caio César Da Silva Barros, Mara Luana Batista Severo, Amanda Katarinny Goes Gonzaga, Lélia Batista De Souza, Éricka Janine Dantas Da Silveira

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ORuORP

Root Dilaceration: Radiographic Analysis in Patients with Nonsyndromic Cleft Lip and/or Palate

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Laís Bastos Guimarães, Gabriela Dos Santos Lopes, Iêda Margarida Crusoé Rebello, Deborah Queiroz De Freitas, Ricardo Della Coletta, Patrícia De Castro Veiga, Silvia Regina De Almeida Reis

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R39HNZ

Ulcerated Lesions in the Oral Mucosa as Manifestations of Arboviruses: a Series of Cases

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Ana Maria Ipólito Barros, Allan Vinícius Martins De Barros, Clarisbalte Martins Sampaio Sá Bezerra, Eudes Euler De Souza Lucena, Samylla Glória De Araújo Costa, Tainara Tejada Camacho, Fábio Andrey Da Costa Araújo

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OTfRi5

Common Oral Lesions in Hospitalized Patients and Physicians' Opinion About the Role of A Dentist in the Hospital

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Paula Sena Da Mata, Claudia Yumi Maeda, Desiree Rosa Cavalcanti, Marcelo Marcucci, Debora Cristina Gonçalves Blanco, Fabiano Vasconcelos

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R4pf3N

In Vitro Investigation of the Antifungal Potential of Pyroligneous Acid

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Lara Moreira Jalles Milani, Rafael Guerra Lund, Rodrigo Galo, Simone Gomes Dias De Oliveira

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OTfHHv

CLIC4 and CLIC4-Associated Proteins in Actinic Cheilitis and Squamous Cell Carcinoma of the Lower Lip

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Maria Luiza Diniz De Sousa Lopes, Francisco Jadson Lima, Márcia Cristina Da Costa Miguel, Lélia Maria Guedes Queiroz, Cassiano Francisco Weege Nonaka, Éricka Janine Dantas Da Silveira

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QZ1ASq

Clinical Profile of Oral Mucosal Lesions in Elderly Patients: A 20-Year Retrospective Study

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Andreia Bufalino, Ana Thais Bagatini, Túlio Morandin Ferrisse, Mariel Ruivo Biancardi, Cláudia Maria Navarro, Elaine Maria Sgavioli Massucato, Darcy Fernandes

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVWCo2

Oral Cancer: Epidemiological Survey of Patients at A Porto Alegre Reference Hospital – Rs/Brazil

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Maria Eduarda L. Baldino, Karen Loureiro Weigert, Francine K.R. Soares

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R27BOh

Psychological Factors as the Main Motivators for Tobacco Use According to the Patients' Own Perception

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Vitor Bonetti Valente, Bruna Amélia Moreira Sarafim Da Silva, Clícia Keiko Sakamoto Nishida, Edilze Fatima Gardenal Fani, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Daniel Galera Bernabé

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVWwga

Retrospective Study of the Oral Cavity Injuries at the Dental Urgency Sector Referenced to the Clinical Stomatology

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): João Pedro Mota Cardoso Almeida Ribeiro, Thainá Fonseca Strina, Sibele Sarti Penha, Irene Graça Azevedo Pina Vaz, Carina Domaneschi

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QYlkWt

Actinic Cheilits: Epidemiological Study in Farmers From Pernambuco, Brazil

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Stefânia Jeronimo Ferreira, Izabelly Germinia Gomes De Melo, Fernando Flávio Souza Vaz, Jardel Jorge Santos, Allan Vinícius Martins De Barros, Eduardo Sérgio Donato Duarte Filho, Marianne De Vasconcelos Carvalho

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OUiQHc

Prognostic Activity of Cyclin D1 in Oral Squamous Cell Carcinoma

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Isabella Bittencourt Do Valle, Thabata Coeli Dias Damasceno, Paola Fernandes Pansini, Willene Dos Santos Machado Zolzaneli, Danielle Resende Camisasca, Hisham Mehanna, Sandra Ventorin Von Zeidler

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R2twEW

Evaluation of Resting and Stimulated Sialometry Techniques in Patients with Rheumatoid Arthritis

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): Érica Passos De Medeiros Lacerda, Isabela Izidoro Ramos, Larissa Santos Fernandes, Sarah Raquel Cavalcanti Bezerra Melo, Alessandra De A.T. Carvalho, Jair Carneiro Leão, Luiz Alcino Gueiros

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVg7NN

Survey of Oral and Maxillofacial Pathology Specimens Submitted by Dental Practitioners: A Study Over A 15-Year Period

Publication date: September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 126, Issue 3

Author(s): José Erivaldo Da Silva Mendes, Augusto César Leal Da Silva Leonel, Carla Isabelly Rodrigues Fernandes, Kamilla Karla Maurício Passos, Elaine Judite De Amorim Carvalho, Jurema Freire Lisboa De Castro, Danyel Elias Da Cruz Perez

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Editorial Board

Publication date: October 2018

Source: Journal of Neuroradiology, Volume 45, Issue 6

Author(s):

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Editorial Board

Publication date: October 2018

Source: Journal of Neuroradiology, Volume 45, Issue 6

Author(s):

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Implementing Workshops to Improve Radiation Therapists’ Knowledge and Attitudes about Sexual Health Issues in Cancer Patients

Publication date: Available online 27 September 2018

Source: Journal of Medical Imaging and Radiation Sciences

Author(s): Carina Feuz, Karen Tse, Maisie Kwan, Christine Hill, Peter Rakaric, Kieng Tan, Tara Rosewall

Abstract

Objectives

Although it is widely acknowledged that radiotherapy treatments can have a negative impact on a patient's sexual health, this aspect of side effect management is not commonly addressed by radiation therapists or by other cancer specialists. It is important for radiation therapists to recognize and address possible sexual health issues to provide a holistic approach to care. This quality-improvement project was designed to help radiation therapists discuss the sexual health needs of patients undergoing radiotherapy by improving their clinical knowledge, skills, and comfort level about the topic.

Methods

This study used a cross-sectional descriptive prequestionnaire/postquestionnaire design, in which data were collected from a nonrandom sample of radiation therapists at a single urban radiation therapy center. Participants attended two 90-minute sexual health education workshops specifically designed for radiation therapists and completed online preworkshop/postworkshop questionnaires. All questions were quantitative in nature. The survey consisted of multiple-choice, multiple-select, and five-point Likert-scale questions. Descriptive analysis was used for data analysis.

Results

The results of this improvement project indicated that participants had introductory-level knowledge about how cancer treatments can impact patients' sexual health. Although there is potential for some changes in the general knowledge levels of the participants after the initiative, two general workshops about the topic are not enough to have radiation therapists feel comfortable enough with the topic to change their clinical practice.

Conclusion

This project identified that although radiation therapists acknowledge the importance of discussing sexual health concerns as part of delivering holistic health care, lack of knowledge and expertise with the topic is a main barrier to initiating conversations. To help prepare radiation therapists, education and training initiatives, which build on knowledge and offer opportunities to develop and apply practical skills in both simulated and real-life situations, should be created. This can help to increase confidence in the sexual health counseling provided, which may result in more radiation therapists frequently engaging in these important sexual health conversations.

Résumé

Objectifs

Même s'il est largement admis que les traitements de radiothérapie peuvent avoir des effets négatifs sur la santé sexuelle des patients, cet aspect de la gestion des effets secondaires n'est pas couramment abordé par les radiothérapeutes ou par d'autres spécialistes du cancer. Il est important que les radiothérapeutes soient au courant des problèmes de santé sexuelle liés à la radiothérapie et qu'ils les abordent avec les patients afin de favoriser une approche globale de la santé. Le projet d'amélioration de la qualité dont il est question dans cette étude avait pour but d'aider les radiothérapeutes à discuter des besoins en matière de santé sexuelle des patients bénéficiant d'une radiothérapie, et ce, en améliorant leurs connaissances cliniques et leur capacité à aborder ce sujet avec leurs patients.

Méthodologie

Dans le cadre de cette étude, nous avons adopté une approche transversale et descriptive fondée sur un questionnaire administré avant et après une séance de formation, et les données recueillies proviennent d'un échantillon non aléatoire de radiothérapeutes issus d'un seul centre de radiothérapie urbain. Les participants ont assisté à deux ateliers de 90 minutes sur la santé sexuelle conçus pour les radiothérapeutes. Ils ont rempli un questionnaire électronique avant et après la formation. Toutes les questions étaient de nature quantitative. Le questionnaire comprenait des questions à choix multiples, des questions à plus d'une réponse et des énoncés à quantifier à l'aide d'une échelle de Likert de cinq points. Nous avons eu recours à une analyse descriptive pour l'analyse des données.

Résultats

Les résultats de ce projet d'amélioration indiquent que les participants possédaient des connaissances de niveau élémentaire sur les effets que les traitements du cancer peuvent avoir sur la santé sexuelle des patients. Même s'il est possible d'accroître le niveau de connaissances générales des participants grâce à cette initiative, le fait de suivre deux ateliers d'ordre général à ce sujet ne permettrait pas aux radiothérapeutes de se sentir tout à fait à l'aise dans ce domaine et de modifier leur pratique clinique.

Conclusion

Ce projet nous a permis de conclure que même si les radiothérapeutes reconnaissent qu'il est important de discuter des préoccupations liées à la santé sexuelle dans le cadre d'une approche globale de la santé, le manque de connaissances à ce sujet demeure un obstacle important. Pour mieux préparer les radiothérapeutes, on devrait créer des initiatives de formation qui permettront à ces derniers de tirer profit de leurs connaissances et de perfectionner leurs habiletés pratiques au cours de mises en situation et de situations réelles. Ce genre d'initiatives pourraient contribuer à augmenter leur niveau de confiance lorsqu'ils donnent des conseils liés à la santé sexuelle, et ainsi accroître le nombre de radiothérapeutes qui entament fréquemment ces discussions importantes.

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Implementing Workshops to Improve Radiation Therapists’ Knowledge and Attitudes about Sexual Health Issues in Cancer Patients

Publication date: Available online 27 September 2018

Source: Journal of Medical Imaging and Radiation Sciences

Author(s): Carina Feuz, Karen Tse, Maisie Kwan, Christine Hill, Peter Rakaric, Kieng Tan, Tara Rosewall

Abstract

Objectives

Although it is widely acknowledged that radiotherapy treatments can have a negative impact on a patient's sexual health, this aspect of side effect management is not commonly addressed by radiation therapists or by other cancer specialists. It is important for radiation therapists to recognize and address possible sexual health issues to provide a holistic approach to care. This quality-improvement project was designed to help radiation therapists discuss the sexual health needs of patients undergoing radiotherapy by improving their clinical knowledge, skills, and comfort level about the topic.

Methods

This study used a cross-sectional descriptive prequestionnaire/postquestionnaire design, in which data were collected from a nonrandom sample of radiation therapists at a single urban radiation therapy center. Participants attended two 90-minute sexual health education workshops specifically designed for radiation therapists and completed online preworkshop/postworkshop questionnaires. All questions were quantitative in nature. The survey consisted of multiple-choice, multiple-select, and five-point Likert-scale questions. Descriptive analysis was used for data analysis.

Results

The results of this improvement project indicated that participants had introductory-level knowledge about how cancer treatments can impact patients' sexual health. Although there is potential for some changes in the general knowledge levels of the participants after the initiative, two general workshops about the topic are not enough to have radiation therapists feel comfortable enough with the topic to change their clinical practice.

Conclusion

This project identified that although radiation therapists acknowledge the importance of discussing sexual health concerns as part of delivering holistic health care, lack of knowledge and expertise with the topic is a main barrier to initiating conversations. To help prepare radiation therapists, education and training initiatives, which build on knowledge and offer opportunities to develop and apply practical skills in both simulated and real-life situations, should be created. This can help to increase confidence in the sexual health counseling provided, which may result in more radiation therapists frequently engaging in these important sexual health conversations.

Résumé

Objectifs

Même s'il est largement admis que les traitements de radiothérapie peuvent avoir des effets négatifs sur la santé sexuelle des patients, cet aspect de la gestion des effets secondaires n'est pas couramment abordé par les radiothérapeutes ou par d'autres spécialistes du cancer. Il est important que les radiothérapeutes soient au courant des problèmes de santé sexuelle liés à la radiothérapie et qu'ils les abordent avec les patients afin de favoriser une approche globale de la santé. Le projet d'amélioration de la qualité dont il est question dans cette étude avait pour but d'aider les radiothérapeutes à discuter des besoins en matière de santé sexuelle des patients bénéficiant d'une radiothérapie, et ce, en améliorant leurs connaissances cliniques et leur capacité à aborder ce sujet avec leurs patients.

Méthodologie

Dans le cadre de cette étude, nous avons adopté une approche transversale et descriptive fondée sur un questionnaire administré avant et après une séance de formation, et les données recueillies proviennent d'un échantillon non aléatoire de radiothérapeutes issus d'un seul centre de radiothérapie urbain. Les participants ont assisté à deux ateliers de 90 minutes sur la santé sexuelle conçus pour les radiothérapeutes. Ils ont rempli un questionnaire électronique avant et après la formation. Toutes les questions étaient de nature quantitative. Le questionnaire comprenait des questions à choix multiples, des questions à plus d'une réponse et des énoncés à quantifier à l'aide d'une échelle de Likert de cinq points. Nous avons eu recours à une analyse descriptive pour l'analyse des données.

Résultats

Les résultats de ce projet d'amélioration indiquent que les participants possédaient des connaissances de niveau élémentaire sur les effets que les traitements du cancer peuvent avoir sur la santé sexuelle des patients. Même s'il est possible d'accroître le niveau de connaissances générales des participants grâce à cette initiative, le fait de suivre deux ateliers d'ordre général à ce sujet ne permettrait pas aux radiothérapeutes de se sentir tout à fait à l'aise dans ce domaine et de modifier leur pratique clinique.

Conclusion

Ce projet nous a permis de conclure que même si les radiothérapeutes reconnaissent qu'il est important de discuter des préoccupations liées à la santé sexuelle dans le cadre d'une approche globale de la santé, le manque de connaissances à ce sujet demeure un obstacle important. Pour mieux préparer les radiothérapeutes, on devrait créer des initiatives de formation qui permettront à ces derniers de tirer profit de leurs connaissances et de perfectionner leurs habiletés pratiques au cours de mises en situation et de situations réelles. Ce genre d'initiatives pourraient contribuer à augmenter leur niveau de confiance lorsqu'ils donnent des conseils liés à la santé sexuelle, et ainsi accroître le nombre de radiothérapeutes qui entament fréquemment ces discussions importantes.

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Developmental defects of the enamel and its impact on the oral health quality of life of children resident in Southwest Nigeria

Abstract

Background

Developmental defects of the enamel (DDE) increase the risk for diseases that impact negatively on the quality of life. The objective of this study was to compare the oral health quality of life of children with molar-incisor-hypomineralisation (MIH) and enamel hypoplasia; and assess if caries worsened the impact of these lesions on the quality of life.

Methods

This study recruited 853 6 to 16-years-old school children. They filled the Child-OIDP questionnaire. The MIH, enamel hypoplasia, caries and oral hygiene status was assessed. Poisson regression was used to determine the impact of MIH and enamel hypoplasia on the oral health quality of life, after adjusting for the effect of sex, age, socioeconomic class, oral hygiene and caries status.

Results

The prevalence of MIH and enamel hypoplasia was 2.9% and 7.6% respectively. There was no significant difference in the mean child-OIDP scores of children with or without MIH (p = 0.57), children with or without enamel hypoplasia (p = 0.48), and children with enamel hypoplasia with and without caries (p = 0.30). Children with enamel hypoplasia and caries had worse outcomes for speaking (p = 0.01). Children with middle (AOR: 2.74; 95% CI: 1.60–4.67; P < 0.01) and low (AOR: 1.75; 95% CI: 1.04–2.95; p = 0.03) socioeconomic status, and those with caries (AOR: 2.02; 95% CI: 1.26–3.22; p = 0.03) had their oral health quality of life negatively impacted.

Conclusion

MIH and enamel hypoplasia had no significant impact on the overall oral health quality of life of children resident in southwestern Nigeria. However, children with caries and those from middle and low socioeconomic classes had poorer oral health quality of life.

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Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation

Publication date: Available online 26 September 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Anne M. Fitzpatrick, Leonard B. Bacharier, Theresa W. Guilbert, Daniel J. Jackson, Stanley J. Szefler, Avraham Beigelman, Michael D. Cabana, Ronina Covar, Fernando Holguin, Robert F. Lemanske, Fernando D. Martinez, Wayne Morgan, Wanda Phipatanakul, Jacqueline A. Pongracic, Robert S. Zeiger, David T. Mauger, NIH/NHLBI AsthmaNet

Abstract

Background

Recurrent preschool wheezing is a heterogeneous disorder with significant morbidity, yet little is known about phenotypic determinants and their impact on clinical outcomes.

Objective

Latent class analysis (LCA) was used to identify latent classes of recurrent preschool wheeze and their association with future exacerbations and inhaled corticosteroid (ICS) treatment response.

Methods

Data from five clinical trials of 1,708 children age 12-71 months with recurrent wheezing were merged. LCA was performed on 10 demographic, exposure and sensitization variables to determine the optimal number of latent classes. The primary outcome was the annualized rate of wheezing exacerbations requiring systemic corticosteroids during the study intervention period; the secondary outcome was the time to first exacerbation. Exploratory analyses examined the effect of daily ICS treatment on exacerbation outcomes.

Results

Four latent classes of recurrent wheezing were identified; these were not distinguished by current symptoms or historical exacerbations but differed with regard to allergen sensitization and/or exposures. Annualized exacerbation rates (mean ± SEM/year) were 0.65 ± 0.06 for class 1 ("minimal sensitization"), 0.93 ± 0.10 for class 2 ("sensitization with indoor pet exposure"), 0.60 ± 0.07 for class 3 ("sensitization with tobacco smoke exposure"), and 0.81 ± 0.10 for class 4 ("multiple sensitization and eczema") (p < 0.001). In a research setting of high adherence, daily ICS treatment improved exacerbation rates in classes 2 and 4 but not the other groups.

Conclusion

Sensitization and exposure assessments are useful in the prediction of future exacerbation and may identify children most likely to respond favorably to daily ICS treatment.

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Long-term Outcome of Peanut Oral Immunotherapy Facilitated Initially by Omalizumab

Publication date: Available online 26 September 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Christina S.K. Yee, Sultan Albuhairi, Elizabeth Noh, Kristel El-Khoury, Shervin Rezaei, Azza Abdel-Gadir, Dale T. Umetsu, Elizabeth Burke-Roberts, Jennifer LeBovidge, Lynda Schneider, Rima Rachid

Abstract

Background

We successfully used omalizumab to faciliate peanut oral immunotherapy (OIT) in children with reactivity to ≤50mg peanut protein and with high peanut-IgE (median 229 kU/L).

Objective

We report on long-term OIT outcomes in these patients, including dosing changes, adverse events, peanut immunoglobulin changes and quality of life (QoL).

Methods

Patients were followed for up to 72 months (67 months maintenance). Outcomes were collected on peanut dose amount, form and frequency, as well as adverse events, (QoL), and laboratory studies.

Results

Of 13 patients initially enrolled, 7 patients (54%) continued on peanut OIT through month 72; 6 (46%) discontinued therapy because of adverse reactions. Maintenance peanut protein dose varied between 500-3,500mg. Most patients consumed different peanut-containing products. All patients experienced at least one adverse event, and one patient developed eosinophilic eosphagitis. Peanut- IgE, Arah1-IgE and Arah2-IgE, peanut-SPT, Peanut-IgE:IgE ratio, and Arah2-IgE:Arah2-IgG4 ratio decreased on OIT. Peanut-IgG4, Arah1-IgG4, Arah2-IgG4 initially increased on OIT then decreased, though not falling to baseline levels. In patients who stopped OIT, there was a trend for reversal of these biomarker changes. Higher peanut-IgE and Arah2-IgE at study month 12 was associated with discontinuation. Patient and parent QoL improved from baseline, even in patients who discontinued OIT.

Conclusion

While adjunctive omalizumab allowed for faster and successful desensitization in patients with high peanut-IgE, almost half of patients discontinued OIT within 72 months because of reactions. Patients who stopped therapy had higher month 12 peanut-IgE and Arah2-IgE. It is possible that these patients might benefit from longer omalizumab administration.

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Early exposure to cow’s milk protein is associated with a reduced risk of cow’s milk allergic outcomes.

Publication date: Available online 26 September 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Rachel L. Peters, Jennifer J. Koplin, Shyamali C. Dharmage, Mimi L.K. Tang, Vicki L. McWilliam, Lyle C. Gurrin, Melanie Neeland, Adrian J. Lowe, Anne-Louise Ponsonby, Katrina J. Allen

Abstract

Background

Overall early exposure to allergenic foods in the infant's diet is a new strategy for preventing food allergy to that allergen, but the optimal timing of exposure for different allergens is not known.

Objectives

We aimed to examine the relationship between exposure to cow's milk protein in the first 3 months of life and risk of cow's milk allergy at age 12 months.

Methods

HealthNuts is a longitudinal population-based food allergy study which recruited 5276 12-month old infants. Skin prick testing to cow's milk was conducted on the second half of the cohort (n=2715) and sensitisation defined as a wheal ≥ 2mm. Cow's milk allergy was defined as a parent reported reaction to cow's milk consistent with IgE-mediated allergy together with evidence of sensitisation. Early exposure to cow's milk protein was captured through parental questionnaire administered at one year of age and defined as consumption of cow's milk-based infant formula during the first 3 months of life.

Results

Forty-two percent of infants were exposed to cow's milk in the first 3 months of life (n= 1977/4712) and 87% of these infants were also breastfed. Early exposure to cow's milk protein was associated with a reduced risk of cow's milk sensitisation (aOR 0.44, 95% CI 0.23-0.83), parent-reported reactions to cow's milk (aOR 0.44, 95% CI 0.29-0.67) and cow's milk allergy (aOR 0.31, 95% CI 0.10-0.91) at age 12-months. Age at exposure to cow's milk protein was not associated with the risk of other food allergies.

Conclusion

Exposure to cow's milk protein in the first 3 months of life was associated with a reduced risk of cow's milk allergy. These findings are from an observational study and clinical trials are warranted to further assess this association before any recommendations to infant feeding guidelines can be made.

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Developmental defects of the enamel and its impact on the oral health quality of life of children resident in Southwest Nigeria

Abstract

Background

Developmental defects of the enamel (DDE) increase the risk for diseases that impact negatively on the quality of life. The objective of this study was to compare the oral health quality of life of children with molar-incisor-hypomineralisation (MIH) and enamel hypoplasia; and assess if caries worsened the impact of these lesions on the quality of life.

Methods

This study recruited 853 6 to 16-years-old school children. They filled the Child-OIDP questionnaire. The MIH, enamel hypoplasia, caries and oral hygiene status was assessed. Poisson regression was used to determine the impact of MIH and enamel hypoplasia on the oral health quality of life, after adjusting for the effect of sex, age, socioeconomic class, oral hygiene and caries status.

Results

The prevalence of MIH and enamel hypoplasia was 2.9% and 7.6% respectively. There was no significant difference in the mean child-OIDP scores of children with or without MIH (p = 0.57), children with or without enamel hypoplasia (p = 0.48), and children with enamel hypoplasia with and without caries (p = 0.30). Children with enamel hypoplasia and caries had worse outcomes for speaking (p = 0.01). Children with middle (AOR: 2.74; 95% CI: 1.60–4.67; P < 0.01) and low (AOR: 1.75; 95% CI: 1.04–2.95; p = 0.03) socioeconomic status, and those with caries (AOR: 2.02; 95% CI: 1.26–3.22; p = 0.03) had their oral health quality of life negatively impacted.

Conclusion

MIH and enamel hypoplasia had no significant impact on the overall oral health quality of life of children resident in southwestern Nigeria. However, children with caries and those from middle and low socioeconomic classes had poorer oral health quality of life.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ogjt0F

Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation

Publication date: Available online 26 September 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Anne M. Fitzpatrick, Leonard B. Bacharier, Theresa W. Guilbert, Daniel J. Jackson, Stanley J. Szefler, Avraham Beigelman, Michael D. Cabana, Ronina Covar, Fernando Holguin, Robert F. Lemanske, Fernando D. Martinez, Wayne Morgan, Wanda Phipatanakul, Jacqueline A. Pongracic, Robert S. Zeiger, David T. Mauger, NIH/NHLBI AsthmaNet

Abstract

Background

Recurrent preschool wheezing is a heterogeneous disorder with significant morbidity, yet little is known about phenotypic determinants and their impact on clinical outcomes.

Objective

Latent class analysis (LCA) was used to identify latent classes of recurrent preschool wheeze and their association with future exacerbations and inhaled corticosteroid (ICS) treatment response.

Methods

Data from five clinical trials of 1,708 children age 12-71 months with recurrent wheezing were merged. LCA was performed on 10 demographic, exposure and sensitization variables to determine the optimal number of latent classes. The primary outcome was the annualized rate of wheezing exacerbations requiring systemic corticosteroids during the study intervention period; the secondary outcome was the time to first exacerbation. Exploratory analyses examined the effect of daily ICS treatment on exacerbation outcomes.

Results

Four latent classes of recurrent wheezing were identified; these were not distinguished by current symptoms or historical exacerbations but differed with regard to allergen sensitization and/or exposures. Annualized exacerbation rates (mean ± SEM/year) were 0.65 ± 0.06 for class 1 ("minimal sensitization"), 0.93 ± 0.10 for class 2 ("sensitization with indoor pet exposure"), 0.60 ± 0.07 for class 3 ("sensitization with tobacco smoke exposure"), and 0.81 ± 0.10 for class 4 ("multiple sensitization and eczema") (p < 0.001). In a research setting of high adherence, daily ICS treatment improved exacerbation rates in classes 2 and 4 but not the other groups.

Conclusion

Sensitization and exposure assessments are useful in the prediction of future exacerbation and may identify children most likely to respond favorably to daily ICS treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QYIMmi