Are antithrombotic agents necessary for head and neck microvascular surgery?

The aim of this prospective study was to determine the effect of antithrombotic agents in preventing thrombosis after head and neck reconstructive surgery. A randomized clinical trial of referred patients undergoing free flap surgery between February 2015 and July 2017 was conducted. Four hundred and fifty-four patients were randomly assigned to group A (n=153), administered aspirin and low molecular weight dextran; group B (n=150), administered low molecular weight heparin; and group C (n=151), not administered any antithrombotic agent.

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Towards an asset-based approach to promoting and sustaining well-being for people with aphasia and their families: an international exploratory study

. (Source: Aphasiology)

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Collaborative design of accessible information with people with aphasia

. (Source: Aphasiology)

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The coding of sex in Spanish nouns

Publication date: Available online 24 November 2018Source: LinguaAuthor(s): Carlos-Eduardo PiñerosAbstractTraditional views on how sex is coded in Spanish nouns are revolutionized in this article. To the initial discovery that sex coding yields not only singlets and doublets but also triplets, it is added that Spanish employs three sex coding modes whose productivity correlates with structural cost. The suppletive and the derivational modes require investing in sex-specific morphemes, which makes them costly, whereas the inflectional mode achieves maximal economy by exploiting the exponent of another grammatical category: declension. The transfer of productive sex coding to the grammar is another major innovation. Lexical Specification is appropriate to formalize the suppletive and the de...

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Vicenin-2 ameliorates oxidative damage and photoaging via modulation of MAPKs and MMPs signaling in UVB radiation exposed human skin cells

In this study, UVB-irradiation (100 mJ/cm2) significantly elevated the intracellular ROS levels, lipid peroxidation, DNA damage, depletion of antioxidants resulted in apoptotic HDF cells. Interestingly, HDF cells were administrated with vicenin-2, 1 h before UVB-irradiation prevents ROS generation, TBARS, apoptotic changes and DNA damage in HDF. MAPKs and MMP signaling are implicated in oxidative stress and photoaging; these signaling events are considered as photoaging and differentiation. We found that Vicenin-2 prevents over expression of MAPKs (p-ERK1, p-JNK & p-p38), AP-1 and MMPs (MMP-2, 9 & 12) in during the exposure of UVB in HDF cells. These findings conclude that vicenin-2 could be a potential bioactive ingredient to absorb UV photons and protects the dermal cells from the UV...

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The second-order effect of orthography-to-phonology mapping consistency on Chinese spoken word recognition

Publication date: August 2019Source: Journal of Neurolinguistics, Volume 51Author(s): Pei-Chun Chao, Wei-Fan Chen, Chia-Ying LeeAbstractThe influences of the orthography-to-phonology (O-to-P) mapping consistency as the first-order effect on visual word recognition are well documented. Few studies have investigated the second-order O-to-P consistency effect on spoken word recognition. To address this issue, Experiment 1 asked participants to perform a writing-to-dictation task for 230 Chinese monosyllabic words and found that the response accuracy increased with the homophone density, and the homophone density, O-to-P consistency, and character frequency also affected the generation probability and reaction time of written responses. Experiment 2 involved manipulating the homophone density ...

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Editorial Board

Publication date: December 2018Source: Lingua, Volume 216Author(s): (Source: Lingua)

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Development of grammatical voice marking in Korean: On the causative, middle and passive uses of suffix -i

Publication date: Available online 23 November 2018Source: LinguaAuthor(s): Foong Ha Yap, Mikyung AhnAbstractVoice-markers enable speakers to profile a situation/event in ways that reflect their perspective of 'who' or 'what' is being foregrounded as the discourse unfolds. Our diachronic study focuses on how a versatile voice marker evolves new functions as it competes for its semantic niche with other voice markers. Using data from Old Korean texts written in Kukyel and data from Middle and Modern Korean1 texts written in Hankul from the Sejong historical corpus, we show how Korean suffix -i extends from causative to middle and passive uses through reflexive causatives while competing with voice markers -eci and -key ha-. Our analysis reveals: (i) a relaxation of telicity and spec...

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Biosynthesis and characterization of copper oxide nanoparticles from indigenous fungi and its effect of photothermolysis on human lung carcinoma

In this report, copper oxide nanoparticles (TA-CuO NPs) were synthesized using cell-free extract of Trichoderma asperellum and assessed their photothermal induced anticancerous activity. The fungal mediated TA-CuO NPs was confirmed by the surface plasmon resonance at 285–295 nm. The amide (CO) and aromatic (CC) groups in secondary metabolites of the extract was found to be an encapsulating or reducing agents for TA-CuO NPs, as indicated by IR spectra. Crystalline nature by cubic face-centered structure of the TA-CuO NPs was confirmed by XRD and their size ranges from 10 to 190 nm and an average of 110 nm by particle size analyzer (PSA). The Ultra HRSEM study revealed spherical shaped TA-CuO NPs. The FETEM results were also in strong agreement with PSA and UHR SEM. The survey-scan s...

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Concrete and abstract word processing in deep dyslexia

Publication date: Available online 23 November 2018Source: Journal of NeurolinguisticsAuthor(s): Simritpal Kaur Malhi, Tara Lynn McAuley, Brette Lansue, Lori BuchananAbstractThe purpose of this case study was to test the failure of inhibition theory of deep dyslexia (FIT; Buchanan, McEwen, Westbury, & Libben, 2003) with concrete and abstract words. FIT proposes that in deep dyslexia, errors to abstract words are the result of an impairment in phonological output lexicon selection rather than a semantic deficit for abstract words. FIT also proposes a dissociation between explicit phonological lexicon production (can be compromised) and implicit access of representations (is intact). With such assumptions it follows that in phonologically implicit tasks where controls demonstrate either conc...

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The creation of a new vowel category by adult learners after adaptive phonetic training

Publication date: January 2019Source: Journal of Phonetics, Volume 72Author(s): Izabelle Grenon, Mikio Kubota, Chris SheppardAbstractNative Japanese speakers often perceive English vowels based on their duration, whereas native speakers use spectral cues (formant frequencies). The current study examined whether 23 Japanese adult learners of English could create a new vowel category along the spectral dimension after phonetic training with the English vowels /i/-/ɪ/ as in beat and bit. As in previous training studies, the Japanese trainees improved their ability to categorize the vowels in tokens included in the training, and were able to generalize to novel tokens and talkers. A cue-weighting task confirmed that the Japanese trainees categorized the vowels based on temporal cues before tr...

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Anticancer, antimicrobial and photocatalytic activities of green synthesized magnesium oxide nanoparticles (MgONPs) using aqueous extract of Sargassum wightii

Publication date: Available online 23 November 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Arivalagan Pugazhendhi, Raju Prabhu, Kavitha Muruganantham, Rajasree Shanmuganathan, Suganthy NatarajanAbstractA rapid and ecofriendly fabrication of metal oxide nanoparticles using biogenic sources is the current trend being used to replace the toxic chemical method. The present study was carried out to synthesize magnesium oxide nanoparticles (MgONPs) using the marine brown algae Sargassum wighitii as the reducing and capping agent. The as-prepared MgONPs were characterized by spectroscopic and microscopic analyses. UV–visible spectrum of the MgONPs showed a sharp absorption peak at 322 nm. X- ray diffraction analysis illustrated that the MgONPs were crystalline ...

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Biosynthesized of reduced graphene oxide nanosheets and its loading with paclitaxel for their anti cancer effect for treatment of lung cancer

Publication date: Available online 22 November 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Shaobing Lin, Junshan Ruan, Shaoming WangAbstractMultifunctional nanocarriers are in immediate need to develop anticancer activity for the treatment of cancers. In the present research, the graphene oxide was reduced via an efficient method which reduced to RGO by using Euphorbia milii leaves extract. Thus obtained RGO nanocomposites were subsequently characterized by means UV–Vis absorption technique. AFM imaging was further performed in order to analyze the surface morphology of GO nanosheet as well as to estimate the average thickness of the GO nanosheets before and after the addition of Euphorbia milii leaves extract. Furthermore, the anticancer effect of RGO-loa...

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Synthesis of cerium oxide nanoparticles loaded on chitosan for enhanced auto-catalytic regenerative ability and biocompatibility for the spinal cord injury repair

Publication date: Available online 22 November 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Xiutong Fang, Hongxing SongAbstractBiomedical applications like spinal cord injury repair; anticancer requires functional platforms and specific properties like antioxidant, autocatalytic and biocompatibility. This work demonstrated the synthesis of CeO2 nanoparticles which is shown to have promising applications in various fields exclusively biomedical field like scavenging of reactive oxygen species which is mainly responsible for carcinogenic effects. CeO2 nanoparticles were synthesized using the biocompatible ionic liquid followed by their loading with biopolymeric chitosan which was obtained by the deacetylation processing of chitin arrived from the shells of crab...

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‘Invisible minorities’ and ‘hidden diversity’ in Saint-Petersburg's linguistic landscape

Publication date: Available online 23 November 2018Source: Language & CommunicationAuthor(s): Vlada Baranova, Kapitolina FedorovaAbstractThe article deals with representation of labour migrants' languages in St. Petersburg's linguistic landscape. The data analyzed in the article were gathered through fieldwork (in 2016–2017) in different districts of the city. The communication between the majority and ethnic minorities is conducted only in Russian, both in official and in informal exchanges, such as between commercial agencies and non-Russian speakers. Even in places with no official regulation, non-Russian languages' use is significantly rare and occurs predominantly in the frame of in-group communication. Only two languages, Chinese and Uzbek, occasionally can be used in adverti...

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Editorial Board

Publication date: January 2019Source: Language Sciences, Volume 71Author(s): (Source: Language Sciences)

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Look at Mommy: An Exploratory Study of Attention-Related Communication in Mothers of Toddlers at Risk for Autism

. (Source: Language Learning and Development)

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How Children Identify Events from Visual Experience

. (Source: Language Learning and Development)

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Estimation of implant size based on mammograms in immediate breast reconstruction

Abstract

Background

Implant size selection is a critical component of preoperative planning for immediate breast reconstruction. This paper introduces a novel formula, based on preoperative mammograms, for estimating implant volume in patients undergoing immediate breast reconstruction.

Methods

A retrospective analysis of 115 consecutive patients with immediate breast reconstruction following skin or nipple sparing mastectomy was performed. A calculated implant size was obtained using the formula, calculated implant size (ml) = π × height (cm) × [base width (cm) − 3]. The calculations were performed independently by two surgeons and based on the ipsilateral preoperative mammogram. The calculated implant size was compared with the actual implant size used during the surgery and results were analysed.

Results

The mean calculated and actual implant sizes were 376.03 ml and 324.49 ml, respectively. There was no difference found between calculated and actual implant sizes (t = − 1.704, p = 0.090), and there was a strong positive correlation between calculated and actual implant sizes (r = 0.7748, p < 0.00001). Further analysis revealed greater accuracy of the formula in patients with an estimated implant size of less than 350 ml, and a tendency to overestimate implant size in breasts with an estimated volume of more than 350 ml.

Conclusions

The mammography-based formula is a simple and practical method to estimate implant size preoperatively. Ultimately, implant selection for the best possible cosmetic outcome is a multifactorial process, of which breast volume is one consideration. This formula can serve as a useful adjunct for preoperative assessment.

Level of Evidence: Level III, diagnostic study.

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Defining mechanisms of pathogenesis in cutaneous leishmaniasis to develop new approaches to therapy

IIG Seminar Phil Scott received his Ph.D. from the University of Pennsylvania in 1980 where he studied immunoregulatory mechanisms in experimental cutaneous leishmaniasis, and from there went to Dr. Alan Sher ' s laboratory at NIH where he defined the role of CD4+ Th1 and Th2 cells in controlling leishmaniasis. He left NIH in 1989 to return to Penn, and rose through the ranks to become Professor of Immunology in 1995. During his time at Penn he served for 12 years as Chair of the Department of Pathobiology in the School of Veterinary Medicine, and is currently Vice Dean for Research& Academic Resources. Dr. Scott ' s current research is focused on understanding the immunologic responses that promote protection and pathology in cutaneous leishmaniasis, with the goal of developing a leis...

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2018 Kinyoun Lecture - Opioids: Epidemic of our time and impact on infectious disease

Robert R. Redfield, M.D., director of the Centers for Disease Control and Prevention (CDC), will deliver the 2018 Joseph J. Kinyoun Memorial Lecture on the intersection between the national opioid crisis and the management of infectious diseases. Titled, " Opioids: Epidemic of Our Time and Impact on Infectious Disease, " Dr. Redfield ' s talk will explore the impacts of the unprecedented use of opioids in the United States on the management of infectious diseases. While overdose remains the leading cause of death among people who use opioids, this population is also disproportionately affected by viral hepatitis, bacterial endocarditis, HIV and other infections associated with sharing and reusing needles to inject drugs and other behaviors linked to illicit drug use. The opioid epide...

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Estimation of implant size based on mammograms in immediate breast reconstruction

Abstract

Background

Implant size selection is a critical component of preoperative planning for immediate breast reconstruction. This paper introduces a novel formula, based on preoperative mammograms, for estimating implant volume in patients undergoing immediate breast reconstruction.

Methods

A retrospective analysis of 115 consecutive patients with immediate breast reconstruction following skin or nipple sparing mastectomy was performed. A calculated implant size was obtained using the formula, calculated implant size (ml) = π × height (cm) × [base width (cm) − 3]. The calculations were performed independently by two surgeons and based on the ipsilateral preoperative mammogram. The calculated implant size was compared with the actual implant size used during the surgery and results were analysed.

Results

The mean calculated and actual implant sizes were 376.03 ml and 324.49 ml, respectively. There was no difference found between calculated and actual implant sizes (t = − 1.704, p = 0.090), and there was a strong positive correlation between calculated and actual implant sizes (r = 0.7748, p < 0.00001). Further analysis revealed greater accuracy of the formula in patients with an estimated implant size of less than 350 ml, and a tendency to overestimate implant size in breasts with an estimated volume of more than 350 ml.

Conclusions

The mammography-based formula is a simple and practical method to estimate implant size preoperatively. Ultimately, implant selection for the best possible cosmetic outcome is a multifactorial process, of which breast volume is one consideration. This formula can serve as a useful adjunct for preoperative assessment.

Level of Evidence: Level III, diagnostic study.

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Defining mechanisms of pathogenesis in cutaneous leishmaniasis to develop new approaches to therapy

IIG Seminar Phil Scott received his Ph.D. from the University of Pennsylvania in 1980 where he studied immunoregulatory mechanisms in experimental cutaneous leishmaniasis, and from there went to Dr. Alan Sher ' s laboratory at NIH where he defined the role of CD4+ Th1 and Th2 cells in controlling leishmaniasis. He left NIH in 1989 to return to Penn, and rose through the ranks to become Professor of Immunology in 1995. During his time at Penn he served for 12 years as Chair of the Department of Pathobiology in the School of Veterinary Medicine, and is currently Vice Dean for Research& Academic Resources. Dr. Scott ' s current research is focused on understanding the immunologic responses that promote protection and pathology in cutaneous leishmaniasis, with the goal of developing a leis...

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2018 Kinyoun Lecture - Opioids: Epidemic of our time and impact on infectious disease

Robert R. Redfield, M.D., director of the Centers for Disease Control and Prevention (CDC), will deliver the 2018 Joseph J. Kinyoun Memorial Lecture on the intersection between the national opioid crisis and the management of infectious diseases. Titled, " Opioids: Epidemic of Our Time and Impact on Infectious Disease, " Dr. Redfield ' s talk will explore the impacts of the unprecedented use of opioids in the United States on the management of infectious diseases. While overdose remains the leading cause of death among people who use opioids, this population is also disproportionately affected by viral hepatitis, bacterial endocarditis, HIV and other infections associated with sharing and reusing needles to inject drugs and other behaviors linked to illicit drug use. The opioid epide...

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Estimation of implant size based on mammograms in immediate breast reconstruction

Abstract

Background

Implant size selection is a critical component of preoperative planning for immediate breast reconstruction. This paper introduces a novel formula, based on preoperative mammograms, for estimating implant volume in patients undergoing immediate breast reconstruction.

Methods

A retrospective analysis of 115 consecutive patients with immediate breast reconstruction following skin or nipple sparing mastectomy was performed. A calculated implant size was obtained using the formula, calculated implant size (ml) = π × height (cm) × [base width (cm) − 3]. The calculations were performed independently by two surgeons and based on the ipsilateral preoperative mammogram. The calculated implant size was compared with the actual implant size used during the surgery and results were analysed.

Results

The mean calculated and actual implant sizes were 376.03 ml and 324.49 ml, respectively. There was no difference found between calculated and actual implant sizes (t = − 1.704, p = 0.090), and there was a strong positive correlation between calculated and actual implant sizes (r = 0.7748, p < 0.00001). Further analysis revealed greater accuracy of the formula in patients with an estimated implant size of less than 350 ml, and a tendency to overestimate implant size in breasts with an estimated volume of more than 350 ml.

Conclusions

The mammography-based formula is a simple and practical method to estimate implant size preoperatively. Ultimately, implant selection for the best possible cosmetic outcome is a multifactorial process, of which breast volume is one consideration. This formula can serve as a useful adjunct for preoperative assessment.

Level of Evidence: Level III, diagnostic study.

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Estimation of implant size based on mammograms in immediate breast reconstruction

Abstract

Background

Implant size selection is a critical component of preoperative planning for immediate breast reconstruction. This paper introduces a novel formula, based on preoperative mammograms, for estimating implant volume in patients undergoing immediate breast reconstruction.

Methods

A retrospective analysis of 115 consecutive patients with immediate breast reconstruction following skin or nipple sparing mastectomy was performed. A calculated implant size was obtained using the formula, calculated implant size (ml) = π × height (cm) × [base width (cm) − 3]. The calculations were performed independently by two surgeons and based on the ipsilateral preoperative mammogram. The calculated implant size was compared with the actual implant size used during the surgery and results were analysed.

Results

The mean calculated and actual implant sizes were 376.03 ml and 324.49 ml, respectively. There was no difference found between calculated and actual implant sizes (t = − 1.704, p = 0.090), and there was a strong positive correlation between calculated and actual implant sizes (r = 0.7748, p < 0.00001). Further analysis revealed greater accuracy of the formula in patients with an estimated implant size of less than 350 ml, and a tendency to overestimate implant size in breasts with an estimated volume of more than 350 ml.

Conclusions

The mammography-based formula is a simple and practical method to estimate implant size preoperatively. Ultimately, implant selection for the best possible cosmetic outcome is a multifactorial process, of which breast volume is one consideration. This formula can serve as a useful adjunct for preoperative assessment.

Level of Evidence: Level III, diagnostic study.

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Assessing staining resistance of a CAD/CAM interpenetrating network composite material

Color change of dental materials over time because of staining agents has important effects on the long-term prognosis of dental esthetic treatments. In the present study, staining resistance of an interpenetr...

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Assessing staining resistance of a CAD/CAM interpenetrating network composite material

Color change of dental materials over time because of staining agents has important effects on the long-term prognosis of dental esthetic treatments. In the present study, staining resistance of an interpenetr...

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Scientists Confirm There’s Nothing But Misinformation On Anti-Vax Sites

Source: Huffington Post, LIFE Author: Agata Blaszczak-Boxe Date: 11/04/18 Many websites that promote unscientific views about vaccinations use pseudoscience and misinformation to […]

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Scientists Confirm There’s Nothing But Misinformation On Anti-Vax Sites

Source: Huffington Post, LIFE Author: Agata Blaszczak-Boxe Date: 11/04/18 Many websites that promote unscientific views about vaccinations use pseudoscience and misinformation to […]

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Scientists Confirm There’s Nothing But Misinformation On Anti-Vax Sites

Source: Huffington Post, LIFE Author: Agata Blaszczak-Boxe Date: 11/04/18 Many websites that promote unscientific views about vaccinations use pseudoscience and misinformation to […]

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NIH-funded researchers identify how hantaviruses infect the lungs

(NIH/National Institute of Allergy and Infectious Diseases) A human protein associated with asthma is key to how hantaviruses infect the lungs and sometimes cause the life-threatening pulmonary condition hantavirus pulmonary syndrome (HPS), according to researchers supported by NIH. They say the most prevalent hantaviruses in North America (Sin Nombre virus) and South America (Andes virus) can recognize the protein, protocadherin-1 (PCDH1), and exploit it to infect the lungs. They hope that disrupting that recognition event could lead to a therapeutic against HPS. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Scientists Confirm There’s Nothing But Misinformation On Anti-Vax Sites

Source: Huffington Post, LIFE Author: Agata Blaszczak-Boxe Date: 11/04/18 Many websites that promote unscientific views about vaccinations use pseudoscience and misinformation to […]

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NIH-funded researchers identify how hantaviruses infect the lungs

(NIH/National Institute of Allergy and Infectious Diseases) A human protein associated with asthma is key to how hantaviruses infect the lungs and sometimes cause the life-threatening pulmonary condition hantavirus pulmonary syndrome (HPS), according to researchers supported by NIH. They say the most prevalent hantaviruses in North America (Sin Nombre virus) and South America (Andes virus) can recognize the protein, protocadherin-1 (PCDH1), and exploit it to infect the lungs. They hope that disrupting that recognition event could lead to a therapeutic against HPS. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Request for Information (RFI): Soliciting Input on the National Institutes of Allergy and Infectious Diseases (NIAID) New Innovator Awards (DP2 Clinical Trials Optional)

Notice NOT-AI-19-013 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))

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Request for Information (RFI): Soliciting Input on the National Institutes of Allergy and Infectious Diseases (NIAID) New Innovator Awards (DP2 Clinical Trials Optional)

Notice NOT-AI-19-013 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))

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Remote Real-Time Ultrasound Supervision via Commercially Available and Low-Cost Tele-Ultrasound: a Mixed Methods Study of the Practical Feasibility and Users’ Acceptability in an Emergency Department

Abstract

Minor emergency departments (ED) struggle to access sufficient expertise to supervise learners of lung and cardiac point-of-care ultrasound (POCUS). Using tele-ultrasound (tele-US) for remote supervision may remedy this situation. We aimed to evaluate the feasibility of real-time supervision via tele-US when applied to an everyday ED clinic. We conducted a mixed methods study that assessed practical feasibility, determined performance, and explored users' acceptability of supervision via tele-US. Technical performance was assessed quantitatively by the ratio in mean gray value between images on site and as received by the supervisor, and by after-compression frame rate. Qualitatively, 12 exploratory semi-structured interviews were conducted with exposed junior doctors and supervisors. Remote supervision via tele-US was performed with 10 junior doctors scanning 45 included patients. During performance assessment, neither alternating internet connection nor software significantly changed the mean gray value ratio. The lowest median frame rate of 4.6 (interquartile range [IQR]: 3.1–5.0) was found by using a 4G internet connection; the highest of 28.5 (IQR: 28.5–29.0) was found with alternative computer and local area network internet connection. In interviews, supervisors stressed the importance of preserving frame rate, and junior doctors emphasized a need for shared ultrasound terminology. In the qualitative analysis, setup mobility, accessibility, and time consumption were emphasized as being of key importance for future clinical implementations. Remote supervision via a commercially available and low-cost tele-US setup is operational for both junior doctors and supervisors when applied to lung and cardiac POCUS scans of hospitalized patients.

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Osteitis pubis oder Symphysitis pubis

Zusammenfassung

Klinisches/methodisches Problem

Die Osteitis pubis ist eine der häufigsten Ursachen chronischer Leistenschmerzen bei vielen Spitzenathleten. Die Symphysitis mit Instabilität des Gelenks, u. a. durch Aufweichung der Gelenkkapsel und muskuläres Ungleichgewicht der entspringenden Muskeln, erhöht wiederum die Instabilität der Symphysenregion, was zu einem Teufelskreis führen kann.

Radiologische Standardverfahren

Das Bildgebungsverfahren der Wahl zur Diagnostik einer Osteitis pubis ist die Magnetresonanztomographie (MRT).

Methodische Innovationen

Es wird ein optimiertes MRT-Sequenzprotokoll angefertigt durch schräge (axial oblique) Schichten parallel zur Linea arcuata ossis ilii sowie den kombinierten Einsatz von Sequenzen mit einem großen Bildfeld über das gesamte Becken und hochauflösenden Sequenzen fokussiert auf die Symphysenregion.

Leistungsfähigkeit

Kürzlich wurde die Korrelation zwischen MRT-Zeichen einer Osteitis pubis und dem langfristigen klinischen Outcome in einem Kollektiv von Hochleistungssportlern untersucht. Es zeigte sich, dass insbesondere ein Ödem im periossären Gewebe und isolierte Muskelläsionen an der Symphyse mit einem schlechten klinischen Zustand der Athleten bei Beginn der Symptome verbunden waren. Des Weiteren wurde eine signifikante Assoziation einer erhöhten normierten Signalintensität im Os pubis in STIR(„short-tau inversion recovery")-Sequenzen (sprich: der Ausprägung eines Knochenmarködems) und einer fehlenden kompletten klinischen Besserung beobachtet.

Bewertung

Ein optimiertes MRT-Protokoll erlaubt die Diagnose der Osteitis pubis und ergibt wichtige prognostische Informationen.

Empfehlung für die Praxis

Bei klinischem Verdacht auf Osteitis pubis sollte eine MRT-Bildgebung mit optimiertem Sequenzprotokoll erfolgen.

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Remote Real-Time Ultrasound Supervision via Commercially Available and Low-Cost Tele-Ultrasound: a Mixed Methods Study of the Practical Feasibility and Users’ Acceptability in an Emergency Department

Abstract

Minor emergency departments (ED) struggle to access sufficient expertise to supervise learners of lung and cardiac point-of-care ultrasound (POCUS). Using tele-ultrasound (tele-US) for remote supervision may remedy this situation. We aimed to evaluate the feasibility of real-time supervision via tele-US when applied to an everyday ED clinic. We conducted a mixed methods study that assessed practical feasibility, determined performance, and explored users' acceptability of supervision via tele-US. Technical performance was assessed quantitatively by the ratio in mean gray value between images on site and as received by the supervisor, and by after-compression frame rate. Qualitatively, 12 exploratory semi-structured interviews were conducted with exposed junior doctors and supervisors. Remote supervision via tele-US was performed with 10 junior doctors scanning 45 included patients. During performance assessment, neither alternating internet connection nor software significantly changed the mean gray value ratio. The lowest median frame rate of 4.6 (interquartile range [IQR]: 3.1–5.0) was found by using a 4G internet connection; the highest of 28.5 (IQR: 28.5–29.0) was found with alternative computer and local area network internet connection. In interviews, supervisors stressed the importance of preserving frame rate, and junior doctors emphasized a need for shared ultrasound terminology. In the qualitative analysis, setup mobility, accessibility, and time consumption were emphasized as being of key importance for future clinical implementations. Remote supervision via a commercially available and low-cost tele-US setup is operational for both junior doctors and supervisors when applied to lung and cardiac POCUS scans of hospitalized patients.

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Osteitis pubis oder Symphysitis pubis

Zusammenfassung

Klinisches/methodisches Problem

Die Osteitis pubis ist eine der häufigsten Ursachen chronischer Leistenschmerzen bei vielen Spitzenathleten. Die Symphysitis mit Instabilität des Gelenks, u. a. durch Aufweichung der Gelenkkapsel und muskuläres Ungleichgewicht der entspringenden Muskeln, erhöht wiederum die Instabilität der Symphysenregion, was zu einem Teufelskreis führen kann.

Radiologische Standardverfahren

Das Bildgebungsverfahren der Wahl zur Diagnostik einer Osteitis pubis ist die Magnetresonanztomographie (MRT).

Methodische Innovationen

Es wird ein optimiertes MRT-Sequenzprotokoll angefertigt durch schräge (axial oblique) Schichten parallel zur Linea arcuata ossis ilii sowie den kombinierten Einsatz von Sequenzen mit einem großen Bildfeld über das gesamte Becken und hochauflösenden Sequenzen fokussiert auf die Symphysenregion.

Leistungsfähigkeit

Kürzlich wurde die Korrelation zwischen MRT-Zeichen einer Osteitis pubis und dem langfristigen klinischen Outcome in einem Kollektiv von Hochleistungssportlern untersucht. Es zeigte sich, dass insbesondere ein Ödem im periossären Gewebe und isolierte Muskelläsionen an der Symphyse mit einem schlechten klinischen Zustand der Athleten bei Beginn der Symptome verbunden waren. Des Weiteren wurde eine signifikante Assoziation einer erhöhten normierten Signalintensität im Os pubis in STIR(„short-tau inversion recovery")-Sequenzen (sprich: der Ausprägung eines Knochenmarködems) und einer fehlenden kompletten klinischen Besserung beobachtet.

Bewertung

Ein optimiertes MRT-Protokoll erlaubt die Diagnose der Osteitis pubis und ergibt wichtige prognostische Informationen.

Empfehlung für die Praxis

Bei klinischem Verdacht auf Osteitis pubis sollte eine MRT-Bildgebung mit optimiertem Sequenzprotokoll erfolgen.

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NIH-funded researchers identify how hantaviruses infect the lungs

(NIH/National Institute of Allergy and Infectious Diseases) A human protein associated with asthma is key to how hantaviruses infect the lungs and sometimes cause the life-threatening pulmonary condition hantavirus pulmonary syndrome (HPS), according to researchers supported by NIH. They say the most prevalent hantaviruses in North America (Sin Nombre virus) and South America (Andes virus) can recognize the protein, protocadherin-1 (PCDH1), and exploit it to infect the lungs. They hope that disrupting that recognition event could lead to a therapeutic against HPS. (Source: EurekAlert! - Infectious and Emerging Diseases)

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NIH-funded researchers identify how hantaviruses infect the lungs

(NIH/National Institute of Allergy and Infectious Diseases) A human protein associated with asthma is key to how hantaviruses infect the lungs and sometimes cause the life-threatening pulmonary condition hantavirus pulmonary syndrome (HPS), according to researchers supported by NIH. They say the most prevalent hantaviruses in North America (Sin Nombre virus) and South America (Andes virus) can recognize the protein, protocadherin-1 (PCDH1), and exploit it to infect the lungs. They hope that disrupting that recognition event could lead to a therapeutic against HPS. (Source: EurekAlert! - Infectious and Emerging Diseases)

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2D/3D CMR tissue tracking versus CMR tagging in the assessment of spontaneous T2DM rhesus monkeys with isolated diastolic dysfunction

Abstract

Background

Spontaneous T2DM in rhesus monkeys manifests as isolated diastolic dysfunction in the early stage of diabetic cardiomyopathy, similar to humans. Myocardial deformation measurements have emerged as a superior way to measure left ventricular (LV) function in the early stage of cardiac dysfunction, making it possible to further evaluate early-stage LV dysfunction in spontaneous T2DM rhesus monkeys.

Methods

Spontaneous T2DM rhesus monkeys with isolated diastolic dysfunction (T2DM-DD, n = 10) and corresponding nondiabetic healthy animals (ND, n = 9) were prospectively scanned for a CMR study. Circumferential and longitudinal peak systolic strain (Ecc, Ell), time to peak strain (tEcc, tEll) and peak diastolic strain rate (CSR, LSR) obtained from 2D/3D CMR-TT were compared with those obtained from CMR tagging separately. In addition, all CMR imaging protocols were performed twice in 9 ND animals to assess test-retest reproducibility.

Results

Compared with the ND group, the T2DM-DD monkeys demonstrated significantly impaired LV Ecc (− 10.63 ± 3.23 vs − 14.18 ± 3.19, p < 0.05), CSR (65.50 ± 14.48 vs 65.50 ± 14.48, p < 0.01), Ell (− 9.11 ± 2.59 vs − 14.17 ± 1.68, p < 0.05), and LSR (59.43 ± 19.17 vs 108.46 ± 22.33, p < 0.01) with the tagging. Only Ecc (− 13.10 ± 2.47 vs − 19.03 ± 3.69, p < 0.01) and CSR (148.90 ± 31.27 vs 202.00 ± 51.88, p < 0.01) were significantly reduced with 2D CMR-TT, and only Ecc (− 13.77 ± 1.98 vs − 17.26 ± 3.78, p < 0.05) was significantly reduced with 3D CMR-TT. Moreover, 2D/3D CMR-TT-derived Ecc and CSR correlated with the corresponding tagging values collectively, with a statistically significant ICC value (p < 0.05). Test-retest repeatability analysis showed that most tagging-derived biomarkers had acceptable repeatability (p < 0.01). In addition, 2D CMR-TT-derived indicators were poorer than those derived from the tagging method but better than those obtained using the 3D method, with larger ICCs except for tEcc (p < 0.05).

Conclusions

LV systolic and diastolic deformations were impaired in spontaneous T2DM rhesus monkeys previously diagnosed with isolated diastolic dysfunction by echocardiography. The 2D CMR-TT-derived Ecc and CSR were effective in the evaluation of the myocardial systolic and diastolic functions of early-diabetic cardiomyopathy, with relatively higher test-retest reproducibility and acceptable correlation with the tagging method compared with the 3D CMR-TT method.

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2D/3D CMR tissue tracking versus CMR tagging in the assessment of spontaneous T2DM rhesus monkeys with isolated diastolic dysfunction

Abstract

Background

Spontaneous T2DM in rhesus monkeys manifests as isolated diastolic dysfunction in the early stage of diabetic cardiomyopathy, similar to humans. Myocardial deformation measurements have emerged as a superior way to measure left ventricular (LV) function in the early stage of cardiac dysfunction, making it possible to further evaluate early-stage LV dysfunction in spontaneous T2DM rhesus monkeys.

Methods

Spontaneous T2DM rhesus monkeys with isolated diastolic dysfunction (T2DM-DD, n = 10) and corresponding nondiabetic healthy animals (ND, n = 9) were prospectively scanned for a CMR study. Circumferential and longitudinal peak systolic strain (Ecc, Ell), time to peak strain (tEcc, tEll) and peak diastolic strain rate (CSR, LSR) obtained from 2D/3D CMR-TT were compared with those obtained from CMR tagging separately. In addition, all CMR imaging protocols were performed twice in 9 ND animals to assess test-retest reproducibility.

Results

Compared with the ND group, the T2DM-DD monkeys demonstrated significantly impaired LV Ecc (− 10.63 ± 3.23 vs − 14.18 ± 3.19, p < 0.05), CSR (65.50 ± 14.48 vs 65.50 ± 14.48, p < 0.01), Ell (− 9.11 ± 2.59 vs − 14.17 ± 1.68, p < 0.05), and LSR (59.43 ± 19.17 vs 108.46 ± 22.33, p < 0.01) with the tagging. Only Ecc (− 13.10 ± 2.47 vs − 19.03 ± 3.69, p < 0.01) and CSR (148.90 ± 31.27 vs 202.00 ± 51.88, p < 0.01) were significantly reduced with 2D CMR-TT, and only Ecc (− 13.77 ± 1.98 vs − 17.26 ± 3.78, p < 0.05) was significantly reduced with 3D CMR-TT. Moreover, 2D/3D CMR-TT-derived Ecc and CSR correlated with the corresponding tagging values collectively, with a statistically significant ICC value (p < 0.05). Test-retest repeatability analysis showed that most tagging-derived biomarkers had acceptable repeatability (p < 0.01). In addition, 2D CMR-TT-derived indicators were poorer than those derived from the tagging method but better than those obtained using the 3D method, with larger ICCs except for tEcc (p < 0.05).

Conclusions

LV systolic and diastolic deformations were impaired in spontaneous T2DM rhesus monkeys previously diagnosed with isolated diastolic dysfunction by echocardiography. The 2D CMR-TT-derived Ecc and CSR were effective in the evaluation of the myocardial systolic and diastolic functions of early-diabetic cardiomyopathy, with relatively higher test-retest reproducibility and acceptable correlation with the tagging method compared with the 3D CMR-TT method.

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Postoperative radiotherapy for T1/2N0M0 mucoepidermoid carcinoma positive for CRTC1/3‐MAML2 fusions

Abstract

Background

The National Comprehensive Cancer Network (NCCN) guidelines recommend considering postoperative radiotherapy (PORT) for completely resected T1/2N0M0 salivary mucoepidermoid carcinomas when they show tumor spillage, perineural invasion, or intermediate/high‐grade histology. CRTC1/3‐MAML2 fusions have been associated with a favorable clinical outcome.

Methods

Forty‐seven T1/2N0M0 mucoepidermoid carcinoma cases positive for CRTC1/3‐MAML2 fusions were completely resected and were not treated with PORT.

Results

Pathologically, none of the cases showed tumor spillage or perineural invasion. Cases with intermediate/high‐grade histology numbered 9 (19%) to 26 (55%) with the currently used 3 different grading systems. During the follow‐up (median 60 months), locoregional tumor recurrence occurred in 4 cases, which were treated with surgery alone. At the last follow‐up (median 60 months; 7‐160), all patients were alive with no evidence of disease.

Conclusion

An excellent prognosis may be achieved without PORT in T1/2N0M0 mucoepidermoid carcinoma patients positive for CRTC1/3‐MAML2 fusions when the tumors are completely resected without tumor spillage.

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Operative technique: Lateral neck dissection

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Postoperative radiotherapy for T1/2N0M0 mucoepidermoid carcinoma positive for CRTC1/3‐MAML2 fusions

Abstract

Background

The National Comprehensive Cancer Network (NCCN) guidelines recommend considering postoperative radiotherapy (PORT) for completely resected T1/2N0M0 salivary mucoepidermoid carcinomas when they show tumor spillage, perineural invasion, or intermediate/high‐grade histology. CRTC1/3‐MAML2 fusions have been associated with a favorable clinical outcome.

Methods

Forty‐seven T1/2N0M0 mucoepidermoid carcinoma cases positive for CRTC1/3‐MAML2 fusions were completely resected and were not treated with PORT.

Results

Pathologically, none of the cases showed tumor spillage or perineural invasion. Cases with intermediate/high‐grade histology numbered 9 (19%) to 26 (55%) with the currently used 3 different grading systems. During the follow‐up (median 60 months), locoregional tumor recurrence occurred in 4 cases, which were treated with surgery alone. At the last follow‐up (median 60 months; 7‐160), all patients were alive with no evidence of disease.

Conclusion

An excellent prognosis may be achieved without PORT in T1/2N0M0 mucoepidermoid carcinoma patients positive for CRTC1/3‐MAML2 fusions when the tumors are completely resected without tumor spillage.

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Operative technique: Lateral neck dissection

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Comparison of NODDI and spherical mean signal for measuring intra-neurite volume fraction

Publication date: Available online 26 November 2018

Source: Magnetic Resonance Imaging

Author(s): Hua Li, Rahul Nikam, Vinay Kandula, Ho Ming Chow, Arabinda K. Choudhary

Abstract

Purpose

Neurite orientation dispersion and density imaging (NODDI) is a clinically feasible approach to measure intra-neurite volume fraction (f_in). However, the sophisticated fitting procedure takes several hours. And the NODDI model relied on several questionable assumptions. Recent analytical work demonstrated that f_in could be simply calculated from the spherical mean signal (MEANS) averaged over all gradient directions with a more solid theoretical foundation. The current study aims to compare NODDI and MEANS for measuring f_in in human brain and investigate the potential of MEANS as a fast approach in clinics.

Methods

NODDI f_in and MEANS f_in were measured and compared on the same dataset. NODDI f_in was obtained using the NODDI MATLAB Toolbox. MEANS f_in is the product of the spherical mean signal and 2bD/π, where D is the intra-neurite intrinsic diffusivity.

Results

NODDI f_in and MEANS f_in maps are similar. The voxel-by-voxel correlation suggests that NODDI f_in and MEANS f_in are approximately equivalent to each other.

Conclusion

MEANS may have potential to serve a fast and simple approach to estimate f_in in clinics.

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Comparison of NODDI and spherical mean signal for measuring intra-neurite volume fraction

Publication date: Available online 26 November 2018

Source: Magnetic Resonance Imaging

Author(s): Hua Li, Rahul Nikam, Vinay Kandula, Ho Ming Chow, Arabinda K. Choudhary

Abstract

Purpose

Neurite orientation dispersion and density imaging (NODDI) is a clinically feasible approach to measure intra-neurite volume fraction (f_in). However, the sophisticated fitting procedure takes several hours. And the NODDI model relied on several questionable assumptions. Recent analytical work demonstrated that f_in could be simply calculated from the spherical mean signal (MEANS) averaged over all gradient directions with a more solid theoretical foundation. The current study aims to compare NODDI and MEANS for measuring f_in in human brain and investigate the potential of MEANS as a fast approach in clinics.

Methods

NODDI f_in and MEANS f_in were measured and compared on the same dataset. NODDI f_in was obtained using the NODDI MATLAB Toolbox. MEANS f_in is the product of the spherical mean signal and 2bD/π, where D is the intra-neurite intrinsic diffusivity.

Results

NODDI f_in and MEANS f_in maps are similar. The voxel-by-voxel correlation suggests that NODDI f_in and MEANS f_in are approximately equivalent to each other.

Conclusion

MEANS may have potential to serve a fast and simple approach to estimate f_in in clinics.

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Assessing staining resistance of a CAD/CAM interpenetrating network composite material

Abstract

Background

Color change of dental materials over time because of staining agents has important effects on the long-term prognosis of dental esthetic treatments. In the present study, staining resistance of an interpenetrating network composite material with different translucency levels (translucent and high translucent) and various surface procedures for finishing were investigated.

Methods

Same shade CAD/CAM interpenetrating network composite specimens having two different translucency levels were prepared using by a water cooling cutting saw. Specimens were grouped and different finishing procedures were performed. Then, specimens were kept in distilled water, red wine and coffee for different periods. Color was evaluated before and after exposure to staining liquids using a clinical spectrophotometer.

Results

In the 7 days Glaze group (ΔE₀₀ > 2.2), color difference was only perceivable in the specimens kept in red wine. In the 28 days red wine high translucent groups, only the high translucent Clinical group showed a clinically acceptable (ΔE₀₀ < 2.2) color change. In the translucent groups kept in red wine, only the translucent Glaze group showed a clinically perceivable color change (ΔE₀₀ > 2.2). In the 28 day measurements, all the translucent groups showed a clinically perceivable color change (ΔE₀₀ > 2.2). Of the translucent groups kept in coffee for 28 days, it was observed that only the translucent Clinical group demonstrated a clinically non-perceivable color change (ΔE₀₀ < 2.2).

Conclusions

All the translucent groups kept in red wine showed a clinically perceivable color change after 28 days. Only the high translucent Clinical Kit group showed a clinically acceptable color change. Among high translucent and translucent specimens kept in coffee only the translucent Clinical group showed a clinically acceptable color change after 28 days.

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Assessing staining resistance of a CAD/CAM interpenetrating network composite material

Abstract

Background

Color change of dental materials over time because of staining agents has important effects on the long-term prognosis of dental esthetic treatments. In the present study, staining resistance of an interpenetrating network composite material with different translucency levels (translucent and high translucent) and various surface procedures for finishing were investigated.

Methods

Same shade CAD/CAM interpenetrating network composite specimens having two different translucency levels were prepared using by a water cooling cutting saw. Specimens were grouped and different finishing procedures were performed. Then, specimens were kept in distilled water, red wine and coffee for different periods. Color was evaluated before and after exposure to staining liquids using a clinical spectrophotometer.

Results

In the 7 days Glaze group (ΔE₀₀ > 2.2), color difference was only perceivable in the specimens kept in red wine. In the 28 days red wine high translucent groups, only the high translucent Clinical group showed a clinically acceptable (ΔE₀₀ < 2.2) color change. In the translucent groups kept in red wine, only the translucent Glaze group showed a clinically perceivable color change (ΔE₀₀ > 2.2). In the 28 day measurements, all the translucent groups showed a clinically perceivable color change (ΔE₀₀ > 2.2). Of the translucent groups kept in coffee for 28 days, it was observed that only the translucent Clinical group demonstrated a clinically non-perceivable color change (ΔE₀₀ < 2.2).

Conclusions

All the translucent groups kept in red wine showed a clinically perceivable color change after 28 days. Only the high translucent Clinical Kit group showed a clinically acceptable color change. Among high translucent and translucent specimens kept in coffee only the translucent Clinical group showed a clinically acceptable color change after 28 days.

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Prognostic value of metabolic tumor volume of pretreatment 18 F-FAMT PET/CT in non-small cell lung Cancer

Abstract

Background

This study aimed to determine the prognostic value of positron emission tomography (PET) metabolic parameters—namely metabolic tumor volume (MTV), total lesion glycolysis (TLG), and total lesion retention (TLR)—on fluorine-18 (¹⁸F) fluorodeoxyglucose (FDG) and L- [3-¹⁸F]-α-methyltyrosine (¹⁸F-FAMT) PET/CT in patients with non-small-cell lung cancer (NSCLC).

Methods

The study group comprised 112 NSCLC patients who underwent ¹⁸F-FDG and ¹⁸F-FAMT PET/CT prior to any therapy. The MTV, TLG, TLR, and maximum standardized uptake value (SUV_max) of the primary tumors were determined. Automatic MTV measurement was performed using PET volume computer assisted reading software. (GE Healthcare). Cox proportional hazards models were built to assess the prognostic value of MTV, TLG (for ¹⁸F-FDG), TLR (for ¹⁸F-FAMT), SUV_max, T stage, N stage, M stage, clinical stage, age, sex, tumor histological subtype, and treatment method (surgery or other therapy) on overall survival (OS).

Results

Higher TNM, higher clinical stage, inoperable status, and higher values for all PET parameters (both ¹⁸F-FAMT and ¹⁸F-FDG PET) were significantly associated (P < 0.05) with shorter OS. Multivariate analysis revealed that a higher MTV of ¹⁸F-FAMT (hazard ratio [HR]: 2.88, CI: 1.63–5.09, P < 0.01) and advanced clinical stage (HR: 5.36, CI: 1.88–15.34, P < 0.01) were significant predictors of shorter OS.

Conclusions

MTV of ¹⁸F-FAMT is of prognostic value for OS in NSCLC cases and can help guide decision-making during patient management.

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Prognostic value of metabolic tumor volume of pretreatment 18 F-FAMT PET/CT in non-small cell lung Cancer

Abstract

Background

This study aimed to determine the prognostic value of positron emission tomography (PET) metabolic parameters—namely metabolic tumor volume (MTV), total lesion glycolysis (TLG), and total lesion retention (TLR)—on fluorine-18 (¹⁸F) fluorodeoxyglucose (FDG) and L- [3-¹⁸F]-α-methyltyrosine (¹⁸F-FAMT) PET/CT in patients with non-small-cell lung cancer (NSCLC).

Methods

The study group comprised 112 NSCLC patients who underwent ¹⁸F-FDG and ¹⁸F-FAMT PET/CT prior to any therapy. The MTV, TLG, TLR, and maximum standardized uptake value (SUV_max) of the primary tumors were determined. Automatic MTV measurement was performed using PET volume computer assisted reading software. (GE Healthcare). Cox proportional hazards models were built to assess the prognostic value of MTV, TLG (for ¹⁸F-FDG), TLR (for ¹⁸F-FAMT), SUV_max, T stage, N stage, M stage, clinical stage, age, sex, tumor histological subtype, and treatment method (surgery or other therapy) on overall survival (OS).

Results

Higher TNM, higher clinical stage, inoperable status, and higher values for all PET parameters (both ¹⁸F-FAMT and ¹⁸F-FDG PET) were significantly associated (P < 0.05) with shorter OS. Multivariate analysis revealed that a higher MTV of ¹⁸F-FAMT (hazard ratio [HR]: 2.88, CI: 1.63–5.09, P < 0.01) and advanced clinical stage (HR: 5.36, CI: 1.88–15.34, P < 0.01) were significant predictors of shorter OS.

Conclusions

MTV of ¹⁸F-FAMT is of prognostic value for OS in NSCLC cases and can help guide decision-making during patient management.

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Inter-mesenteric connections between the superior and inferior mesenteric arteries for left colonic vascularization: implications for colorectal surgery

Abstract

Purpose

There is confusion regarding the names, the number, and the exact location of the colonic arterial arches which provide connections between the superior and inferior (IMA) mesenteric arteries at the level of the left colic angle. The aim of this review was to delineate the "true" colic arches arising in the meso of the left colic angle and to describe their surgical implications.

Methods

A systematic review of the literature was performed using the MEDLINE database. The search included only human studies between 1913 and 2018. All dissection, angiographic, arterial cast and corrosion studies were analyzed.

Results

The terms "Riolan arch", "marginal artery of Drummond", "meandering mesenteric artery" and "Villemin's arch" must no longer be used in the scientific literature. Three arterial arches were found at the level of the left colic angle, permitting the communication between the two arterial mesenteric systems: (1) the Marginal Artery (the most peripheral, found in 100% of cases); (2) the "V" termination of the ascending branch of the left colic artery (LCA), existing in more than 2/3 of cases; and (3) the inter-mesenteric trunk, found more centrally located and existing in less than 1/3 of cases.

Conclusions

Three arterial arches exist at the level of the left colic angle: (1) the Marginal Artery, (2) the "V" termination of the ascending branch of the LCA, and (3) the inter-mesenteric trunk. The knowledge of this anatomy is essential for performing colorectal surgeries involving ligation of the IMA.

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The END of fatal food alergies?

Somewhere between one and five per cent of children now have a serious enough problem to warrant treatment. Nut allergies seem to be for life. It is often serious, and can be fatal. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Peanut Allergy Tx; Probiotics and Gastroenteritis: It's PodMed Double T! (with audio)

(MedPage Today) -- This week's topics also include teens'personality characteristics and mortality risk, and chronic disease outcomes with different provider types (Source: MedPage Today Psychiatry)

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Inter-mesenteric connections between the superior and inferior mesenteric arteries for left colonic vascularization: implications for colorectal surgery

Abstract

Purpose

There is confusion regarding the names, the number, and the exact location of the colonic arterial arches which provide connections between the superior and inferior (IMA) mesenteric arteries at the level of the left colic angle. The aim of this review was to delineate the "true" colic arches arising in the meso of the left colic angle and to describe their surgical implications.

Methods

A systematic review of the literature was performed using the MEDLINE database. The search included only human studies between 1913 and 2018. All dissection, angiographic, arterial cast and corrosion studies were analyzed.

Results

The terms "Riolan arch", "marginal artery of Drummond", "meandering mesenteric artery" and "Villemin's arch" must no longer be used in the scientific literature. Three arterial arches were found at the level of the left colic angle, permitting the communication between the two arterial mesenteric systems: (1) the Marginal Artery (the most peripheral, found in 100% of cases); (2) the "V" termination of the ascending branch of the left colic artery (LCA), existing in more than 2/3 of cases; and (3) the inter-mesenteric trunk, found more centrally located and existing in less than 1/3 of cases.

Conclusions

Three arterial arches exist at the level of the left colic angle: (1) the Marginal Artery, (2) the "V" termination of the ascending branch of the LCA, and (3) the inter-mesenteric trunk. The knowledge of this anatomy is essential for performing colorectal surgeries involving ligation of the IMA.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RklozG

The END of fatal food alergies?

Somewhere between one and five per cent of children now have a serious enough problem to warrant treatment. Nut allergies seem to be for life. It is often serious, and can be fatal. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qk7YpU

Peanut Allergy Tx; Probiotics and Gastroenteritis: It's PodMed Double T! (with audio)

(MedPage Today) -- This week's topics also include teens'personality characteristics and mortality risk, and chronic disease outcomes with different provider types (Source: MedPage Today Psychiatry)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DJjHaQ

Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity

Publication date: Available online 25 November 2018

Source: Journal of Oral Biology and Craniofacial Research

Author(s): Francesco Giovacchini, Caterina Bensi, Stefano Belli, Maria Elena Laurenti, Martina Mandarano, Daniele Paradiso, Michele Giansanti, Antonio Tullio

Abstract

Background

Low-grade intraductal carcinomas are rare, malign tumors of salivary glands most commonly affecting parotid gland. It is a slow-growing tumor considered with a favourable prognosis after surgical excision.

Methods

To define the characteristics and management of low-grade intraductal carcinoma a systematic review was performed using the electronic databases Pubmed, Cochrane and Scopus. A new case report was also described.

Results

Including this case the review of literature identified only 54 cases reported thus far. Demographics, clinical presentation, diagnostic tools, treatment, follow-up and recurrence rate, histological and immunohistochemical patterns of this kind of tumor were summarized.

Conclusion

Low-grade intraductal carcinoma has already been well defined but is important to focus on the fact that in few cases component of high-grade infiltrations have been reported: this may modify surgical approach because a simple tumorectomy may not be enough.

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Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity

Publication date: Available online 25 November 2018

Source: Journal of Oral Biology and Craniofacial Research

Author(s): Francesco Giovacchini, Caterina Bensi, Stefano Belli, Maria Elena Laurenti, Martina Mandarano, Daniele Paradiso, Michele Giansanti, Antonio Tullio

Abstract

Background

Low-grade intraductal carcinomas are rare, malign tumors of salivary glands most commonly affecting parotid gland. It is a slow-growing tumor considered with a favourable prognosis after surgical excision.

Methods

To define the characteristics and management of low-grade intraductal carcinoma a systematic review was performed using the electronic databases Pubmed, Cochrane and Scopus. A new case report was also described.

Results

Including this case the review of literature identified only 54 cases reported thus far. Demographics, clinical presentation, diagnostic tools, treatment, follow-up and recurrence rate, histological and immunohistochemical patterns of this kind of tumor were summarized.

Conclusion

Low-grade intraductal carcinoma has already been well defined but is important to focus on the fact that in few cases component of high-grade infiltrations have been reported: this may modify surgical approach because a simple tumorectomy may not be enough.

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The END of fatal food alergies?

Somewhere between one and five per cent of children now have a serious enough problem to warrant treatment. Nut allergies seem to be for life. It is often serious, and can be fatal. (Source: the Mail online | Health)

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Peanut Allergy Tx; Probiotics and Gastroenteritis: It's PodMed Double T! (with audio)

(MedPage Today) -- This week's topics also include teens'personality characteristics and mortality risk, and chronic disease outcomes with different provider types (Source: MedPage Today Psychiatry)

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The END of fatal food alergies?

Somewhere between one and five per cent of children now have a serious enough problem to warrant treatment. Nut allergies seem to be for life. It is often serious, and can be fatal. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Peanut Allergy Tx; Probiotics and Gastroenteritis: It's PodMed Double T! (with audio)

(MedPage Today) -- This week's topics also include teens'personality characteristics and mortality risk, and chronic disease outcomes with different provider types (Source: MedPage Today Psychiatry)

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Asthma, obesity and targeted interventions: an update

Purpose of review Obese asthma is now widely recognized as a phenotype of difficult asthma that is common and less responsive to traditional asthma treatments, so identifying specific treatments is increasingly important. Recent findings Obesity can lead to asthma through a complex relationship of causes including mechanical, inflammatory, metabolic and genetic factors. Exercise programmes including pulmonary rehabilitation, weight loss via dietary restriction, exercise and bariatric surgery, or combinations of all of these can improve quality of life, symptoms, and exercise capacity, with reductions in medication use and exacerbations, and represent tailored treatment for this phenotype of severe difficult to treat asthmatic patients. Summary Exercise programmes and pulmonary rehabilitation, weight loss programmes targeting 5–10% weight loss and bariatric surgery are effective treatments for the obese asthma phenotype. Correspondence to Douglas C. Cowan, Room 17, 4th Floor Walton Building, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK. Tel: +1 412115451; e-mails: Douglas.cowan@ggc.scot.nhs.uk Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Asthma, obesity and targeted interventions: an update

Purpose of review Obese asthma is now widely recognized as a phenotype of difficult asthma that is common and less responsive to traditional asthma treatments, so identifying specific treatments is increasingly important. Recent findings Obesity can lead to asthma through a complex relationship of causes including mechanical, inflammatory, metabolic and genetic factors. Exercise programmes including pulmonary rehabilitation, weight loss via dietary restriction, exercise and bariatric surgery, or combinations of all of these can improve quality of life, symptoms, and exercise capacity, with reductions in medication use and exacerbations, and represent tailored treatment for this phenotype of severe difficult to treat asthmatic patients. Summary Exercise programmes and pulmonary rehabilitation, weight loss programmes targeting 5–10% weight loss and bariatric surgery are effective treatments for the obese asthma phenotype. Correspondence to Douglas C. Cowan, Room 17, 4th Floor Walton Building, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK. Tel: +1 412115451; e-mails: Douglas.cowan@ggc.scot.nhs.uk Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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BPF Genetics of ILD Study

Conditions:   Lung; Disease, Interstitial, With Fibrosis;   Alveolitis, Extrinsic Allergic;   Bird Fancier's Lung;   Idiopathic Interstitial Pneumonias;   Lung Diseases, Interstitial;   Idiopathic Pulmonary Fibrosis Intervention:   Diagnostic Test: Genetic profiling Sponsors:   NHS Forth Valley;   University of Leicester;   University of Glasgow;   Newcastle University;   British Lung Foundation;   British Pigeon Fanciers Medical Research Not yet recruiting (Source: ClinicalTrials.gov)

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N.I.S of AIT in Adult Patients With House Dust Mite Allergy in Real Practice in France

Conditions:   Allergic Rhinitis Due to House Dust Mite;   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus Intervention:   Drug: Tablet, Dispersible Sponsors:   ALK-Abelló A/S;   ITEC Services Recruiting (Source: ClinicalTrials.gov)

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Landmark PALISADE Trial of AR101 Published in New England Journal of Medicine

BRISBANE, Calif.--(BUSINESS WIRE)--Nov. 18, 2018-- Aimmune Therapeutics, Inc. (Nasdaq:AIMT), a biopharmaceutical company developing treatments for potentially life-threatening food allergies, today announced that the New England Journal of Medicine... (Source: Drugs.com - Clinical Trials)

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Seal, Stopping Atopic Dermatitis and Allergy Study

Conditions:   Eczema, Infantile;   Eczema;   Atopic Dermatitis Eczema;   Atopic Dermatitis Interventions:   Combination Product: Tri-lipid skin barrier cream (Epiceram);   Combination Product: Fluticasone propionate Cream 0.05% Sponsors:   Stanford University;   King's College London;   National Jewish Health Not yet recruiting (Source: ClinicalTrials.gov)

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Pay-it-forward RCT for Gonorrhea and Chlamydia Testing

Conditions:   Gonorrhea Male;   Chlamydia;M Interventions:   Other: Pay-it-forward testing;   Other: Pay as you want Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute on Aging (NIA) Recruiting (Source: ClinicalTrials.gov)

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Audiological Benefit and Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Contact Mini

Condition:   Conductive Hearing Loss Interventions:   Device: Adhear;   Device: Contact Mini (CM) Sponsor:   Dominik Riss Recruiting (Source: ClinicalTrials.gov)

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Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Other: eABR Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

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Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

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Severe tinnitus in a patient with acquired deafness for over 50 years: a case report

There have been many reports on the treatment effect of cochlear implantation and hearing aids in the treatment of tinnitus in patients with severe hearing loss. However, as far as we are aware, there are no r... (Source: BioPsychoSocial Medicine)

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Wireless binaural hearing aid technology for telephone use and listening in wind noise

. (Source: International Journal of Audiology)

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An unusual case of post-cochlear implant performance degradation in a patient with suspected Cogan ’s syndrome

. (Source: Cochlear Implants International)

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BPF Genetics of ILD Study

Conditions:   Lung; Disease, Interstitial, With Fibrosis;   Alveolitis, Extrinsic Allergic;   Bird Fancier's Lung;   Idiopathic Interstitial Pneumonias;   Lung Diseases, Interstitial;   Idiopathic Pulmonary Fibrosis Intervention:   Diagnostic Test: Genetic profiling Sponsors:   NHS Forth Valley;   University of Leicester;   University of Glasgow;   Newcastle University;   British Lung Foundation;   British Pigeon Fanciers Medical Research Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Kx6Vxy

N.I.S of AIT in Adult Patients With House Dust Mite Allergy in Real Practice in France

Conditions:   Allergic Rhinitis Due to House Dust Mite;   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus Intervention:   Drug: Tablet, Dispersible Sponsors:   ALK-Abelló A/S;   ITEC Services Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BvPnij

Landmark PALISADE Trial of AR101 Published in New England Journal of Medicine

BRISBANE, Calif.--(BUSINESS WIRE)--Nov. 18, 2018-- Aimmune Therapeutics, Inc. (Nasdaq:AIMT), a biopharmaceutical company developing treatments for potentially life-threatening food allergies, today announced that the New England Journal of Medicine... (Source: Drugs.com - Clinical Trials)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2KyLZWN

Seal, Stopping Atopic Dermatitis and Allergy Study

Conditions:   Eczema, Infantile;   Eczema;   Atopic Dermatitis Eczema;   Atopic Dermatitis Interventions:   Combination Product: Tri-lipid skin barrier cream (Epiceram);   Combination Product: Fluticasone propionate Cream 0.05% Sponsors:   Stanford University;   King's College London;   National Jewish Health Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BvPg6n

Pay-it-forward RCT for Gonorrhea and Chlamydia Testing

Conditions:   Gonorrhea Male;   Chlamydia;M Interventions:   Other: Pay-it-forward testing;   Other: Pay as you want Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute on Aging (NIA) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Kvxjbf

Audiological Benefit and Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Contact Mini

Condition:   Conductive Hearing Loss Interventions:   Device: Adhear;   Device: Contact Mini (CM) Sponsor:   Dominik Riss Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Bx8aKo

Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Other: eABR Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Kygo7Y

Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results

Conditions:   Vestibular Schwannoma;   Hearing Loss Intervention:   Sponsor:   Christoph Arnoldner Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BxK2He

Severe tinnitus in a patient with acquired deafness for over 50 years: a case report

There have been many reports on the treatment effect of cochlear implantation and hearing aids in the treatment of tinnitus in patients with severe hearing loss. However, as far as we are aware, there are no r... (Source: BioPsychoSocial Medicine)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Kxr0DX

Wireless binaural hearing aid technology for telephone use and listening in wind noise

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BwhQEI

An unusual case of post-cochlear implant performance degradation in a patient with suspected Cogan ’s syndrome

. (Source: Cochlear Implants International)

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Glymphatic Pathway of Gadolinium-Based Contrast Agents Through the Brain: Overlooked and Misinterpreted

Background The "glymphatic system" (GS), a brain-wide network of cerebrospinal fluid microcirculation, supplies a pathway through and out of the central nervous system (CNS); malfunction of the system is implicated in a variety of neurological disorders. In this exploratory study, we analyzed the potential of a new imaging approach that we coined delayed T2-weighted gadolinium-enhanced imaging to visualize the GS in vivo. Methods Heavily T2-weighted fluid-attenuated inversion recovery (hT2w-FLAIR) magnetic resonance imaging was obtained before, and 3 hours and 24 hours after intravenous gadolinium-based contrast agent (GBCA) application in 33 neurologically healthy patients and 7 patients with an impaired blood-brain barrier (BBB) due to cerebral metastases. Signal intensity (SI) was determined in various cerebral fluid spaces, and white matter hyperintensities were quantified by applying the Fazekas scoring system. Findings Delayed hT2w-FLAIR showed GBCA entry into the CNS via the choroid plexus and the ciliary body, with GBCA drainage along perineural sheaths of cranial nerves and along perivascular spaces of penetrating cortical arteries. In all patients and all sites, a significant SI increase was found for the 3 hours and 24 hours time points compared with baseline. Although no significant difference in SI was found between neurologically healthy patients and patients with an impaired BBB, a significant positive correlation between Fazekas scoring system and SI increase in the perivascular spaces 3 hours post injection was shown. Interpretation Delayed T2-weighted gadolinium-enhanced imaging can visualize the GBCA pathway into and through the GS. Presence of GBCAs within the GS might be regarded as part of the natural excretion process and should not be mixed up with gadolinium deposition. Rather, the correlation found between deep white matter hyperintensities, an imaging sign of vascular dementia, and GS functioning demonstrated feasibility to exploit the pathway of GBCAs through the GS for diagnostic purposes. Received for publication September 5, 2018; and accepted for publication, after revision, October 9, 2018. Conflicts of interest and sources funding: none declared. Correspondence to: Alexander Radbruch, MD, JD, Department of Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. E-mail: a.radbruch@dkfz.de. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Negligible Risk of Acute Renal Failure Among Hospitalized Patients After Contrast-Enhanced Imaging With Iodinated Versus Gadolinium-Based Agents

Introduction The potential adverse renal outcome among patients undergoing iodine-based contrast-enhanced computerized tomography (CT) has been questioned recently, given the caution undertaken in patients' selection, hydration protocols, and the low radiocontrast volume, used with advanced imaging equipment. Materials and Methods This study is a retrospective assessment of renal outcome in 12,580 hospitalized patients undergoing contrast-enhanced CT, compared with 754 patients subjected to gadolinium-based magnetic resonance imaging, with subsequent propensity matching for clinical characteristics and potential risk factors. Results The risk of postcontrast acute kidney injury (PC-AKI) was found to be negligible as compared with patients undergoing enhanced magnetic resonance imaging studies, before and after propensity matching (8% vs 7.3% rate of AKI in the nonmatched iodine-based contrast agents [IBCAs] and gadolinium-based contrast agents [GBCAs], respectively, P = 0.3, and 7% in the matched IBCA group, P = 0.9), including comparisons among subgroups with well-defined risk factors such as chronic renal failure, diabetes, older age, and hypertension. However, lower systolic blood pressure before imaging was associated with higher risk to develop PC-AKI after IBCA administration but not with GBCA (for systolic blood pressure lower than 110 mm Hg, odds ratio for AKI after IBCA was 1.49; 95% confidence interval, 1.16–1.88, and after GBCA; odds ratio, 0.12; 95% confidence interval, 0.003–0.73). Conclusions With the current precautions undertaken, the real-life risk of PC-AKI among inpatients undergoing CT is insignificant. Possible reasons for the diverse impact of blood pressure on the propensity to develop acute kidney failure after iodine-based but not gadolinium-based enhancement imaging are discussed. Received for publication September 24, 2018; and accepted for publication, after revision, October 17, 2018. Conflicts of interest and sources of funding: none declared. Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (https://ift.tt/2kq7jVD). Correspondence to: Samuel N. Heyman, MD, Department of Medicine, Hadassah Hebrew University Hospital, Mt Scopus, PO Box 24035, Jerusalem 91240, Israel. E-mail: Heyman@cc.huji.ac.il. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Glymphatic Pathway of Gadolinium-Based Contrast Agents Through the Brain: Overlooked and Misinterpreted

Background The "glymphatic system" (GS), a brain-wide network of cerebrospinal fluid microcirculation, supplies a pathway through and out of the central nervous system (CNS); malfunction of the system is implicated in a variety of neurological disorders. In this exploratory study, we analyzed the potential of a new imaging approach that we coined delayed T2-weighted gadolinium-enhanced imaging to visualize the GS in vivo. Methods Heavily T2-weighted fluid-attenuated inversion recovery (hT2w-FLAIR) magnetic resonance imaging was obtained before, and 3 hours and 24 hours after intravenous gadolinium-based contrast agent (GBCA) application in 33 neurologically healthy patients and 7 patients with an impaired blood-brain barrier (BBB) due to cerebral metastases. Signal intensity (SI) was determined in various cerebral fluid spaces, and white matter hyperintensities were quantified by applying the Fazekas scoring system. Findings Delayed hT2w-FLAIR showed GBCA entry into the CNS via the choroid plexus and the ciliary body, with GBCA drainage along perineural sheaths of cranial nerves and along perivascular spaces of penetrating cortical arteries. In all patients and all sites, a significant SI increase was found for the 3 hours and 24 hours time points compared with baseline. Although no significant difference in SI was found between neurologically healthy patients and patients with an impaired BBB, a significant positive correlation between Fazekas scoring system and SI increase in the perivascular spaces 3 hours post injection was shown. Interpretation Delayed T2-weighted gadolinium-enhanced imaging can visualize the GBCA pathway into and through the GS. Presence of GBCAs within the GS might be regarded as part of the natural excretion process and should not be mixed up with gadolinium deposition. Rather, the correlation found between deep white matter hyperintensities, an imaging sign of vascular dementia, and GS functioning demonstrated feasibility to exploit the pathway of GBCAs through the GS for diagnostic purposes. Received for publication September 5, 2018; and accepted for publication, after revision, October 9, 2018. Conflicts of interest and sources funding: none declared. Correspondence to: Alexander Radbruch, MD, JD, Department of Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. E-mail: a.radbruch@dkfz.de. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rdk7Kt

Negligible Risk of Acute Renal Failure Among Hospitalized Patients After Contrast-Enhanced Imaging With Iodinated Versus Gadolinium-Based Agents

Introduction The potential adverse renal outcome among patients undergoing iodine-based contrast-enhanced computerized tomography (CT) has been questioned recently, given the caution undertaken in patients' selection, hydration protocols, and the low radiocontrast volume, used with advanced imaging equipment. Materials and Methods This study is a retrospective assessment of renal outcome in 12,580 hospitalized patients undergoing contrast-enhanced CT, compared with 754 patients subjected to gadolinium-based magnetic resonance imaging, with subsequent propensity matching for clinical characteristics and potential risk factors. Results The risk of postcontrast acute kidney injury (PC-AKI) was found to be negligible as compared with patients undergoing enhanced magnetic resonance imaging studies, before and after propensity matching (8% vs 7.3% rate of AKI in the nonmatched iodine-based contrast agents [IBCAs] and gadolinium-based contrast agents [GBCAs], respectively, P = 0.3, and 7% in the matched IBCA group, P = 0.9), including comparisons among subgroups with well-defined risk factors such as chronic renal failure, diabetes, older age, and hypertension. However, lower systolic blood pressure before imaging was associated with higher risk to develop PC-AKI after IBCA administration but not with GBCA (for systolic blood pressure lower than 110 mm Hg, odds ratio for AKI after IBCA was 1.49; 95% confidence interval, 1.16–1.88, and after GBCA; odds ratio, 0.12; 95% confidence interval, 0.003–0.73). Conclusions With the current precautions undertaken, the real-life risk of PC-AKI among inpatients undergoing CT is insignificant. Possible reasons for the diverse impact of blood pressure on the propensity to develop acute kidney failure after iodine-based but not gadolinium-based enhancement imaging are discussed. Received for publication September 24, 2018; and accepted for publication, after revision, October 17, 2018. Conflicts of interest and sources of funding: none declared. Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (https://ift.tt/2kq7jVD). Correspondence to: Samuel N. Heyman, MD, Department of Medicine, Hadassah Hebrew University Hospital, Mt Scopus, PO Box 24035, Jerusalem 91240, Israel. E-mail: Heyman@cc.huji.ac.il. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Association between asthma, rhinitis and conjunctivitis multimorbidities with molecular IgE sensitization in adults

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Association between asthma, rhinitis and conjunctivitis multimorbidities with molecular IgE sensitization in adults

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MKSAP: 82-year-old woman with a 1-week history of urinary incontinence

Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. An 82-year-old woman is evaluated for a 1-week history of urinary incontinence with lower abdominal discomfort. She reports no dysuria, fever, or back pain. Medical history is significant for hypertension and allergic reacti on to sulfa drugs, which cause a generalized rash. […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)

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MKSAP: 82-year-old woman with a 1-week history of urinary incontinence

Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. An 82-year-old woman is evaluated for a 1-week history of urinary incontinence with lower abdominal discomfort. She reports no dysuria, fever, or back pain. Medical history is significant for hypertension and allergic reacti on to sulfa drugs, which cause a generalized rash. […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)

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Accidental ingestion of aspirin and non-steroidal anti-inflammatory drugs is common in patients with aspirin-exacerbated respiratory disease

Publication date: Available online 24 November 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Adedapo Kiladejo, Marina Palumbo, Tanya M. Laidlaw

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Accidental ingestion of aspirin and non-steroidal anti-inflammatory drugs is common in patients with aspirin-exacerbated respiratory disease

Publication date: Available online 24 November 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Adedapo Kiladejo, Marina Palumbo, Tanya M. Laidlaw

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TJsJKr