Παρασκευή 7 Δεκεμβρίου 2018

Individual patterns of disfluency across speaking styles: a forensic phonetic investigation of Standard Southern British English

Features of speech related to fluency such as filled and silent pauses, sound prolongations, repetitions and self-interruptions exhibit considerable variation among speakers, yet the speaker-specificity of such features has received little attention inforensic phonetic research. The present study investigates the extent to which individual differences in disfluency behaviour are preserved across different speaking styles, a key concern for forensic speaker comparison cases. Disfluency phenomena in the speech of 20 male speakers of Standard Southern British English undertaking a simulated police interview task are compared with the occurrence of the same set of phenomena in the speech of the same speakers participating in a telephone conversation with an 'accomplice'. The speakers' disfluency features are analysed using TOFFA 'Taxonomy of Fluency Features for Forensic Analysis' (McDougall and Duckworth 2017). Individuals exhibit a wide range of variation in their overall rate of production of disfluency features, and these rates are relatively consistent within-speaker across interview and telephone styles. The results for each specific disfluency feature type also show patterns of relatively consistent behaviour within-speaker across-style for most features. For both interview and telephone styles, discriminant analyses based on speaker profiles of disfluency features demonstrate that disfluency features carry speaker-specific information which could be considered alongside other analyses in forensic speaker comparison cases.



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Connecting Language and Disciplinary Knowledge in English for Specific Purposes: Case Studies in Law, by Alissa J. Harting

Connecting Language and Disciplinary Knowledge in English for Specific Purposes: Case Studies in Law, by Alissa J. Harting (2017), Multilingual Matters xi +191 pp


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The presence of HLA-B75, DR13 homozygosity or DR14 additionally increases the risk of allopurinol induced severe cutaneous adverse reactions in HLA-B*58:01 carriers

Publication date: Available online 7 December 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Ji-Su Shim, James Yun, Mi-Yeong Kim, Soo Jie Chung, Ji Hyun Oh, Dong-Yoon Kang, Jae-Woo Jung, Sang-Heon Cho, Hye-Ryun Kang

Abstract
Background

Although HLA-B*58:01 is a well-known risk factor for the development of allopurinol-induced severe cutaneous adverse reactions (SCARs), most of the HLA-B*58:01 carriers do not suffer from SCARs despite a long-term use of allopurinol. This suggests that there are other risk factors that determine the fate of HLA-B*58:01 carriers.

Objective

The aim of this study was to investigate the additional genetic factors that increases the risk of allopurinol-induced SCARs in HLA-B*58:01 carriers.

Methods

The incidence of allopurinol-induced SCARs was investigated according to coexisting HLA alleles in all subjects with HLA-B*58:01 who took allopurinol between 2003 and 2017. The allopurinol tolerant group was defined as a group who took allopurinol for more than 60 days without developing hypersensitivity and was compared to the allopurinol-induced SCARs group.

Results

Among the retrospective cohort consisting of 367 HLA-B*58:01 carriers treated with allopurinol, 11 (3.0%) were diagnosed with allopurinol-induced SCARs. When HLA-B75, DR13 homozygosity, or DR14 was present, the incidence of SCARs increased up to 22.2% [odds ratio (OR), 19.568; P = 0.015], 20.0% [OR, 38.458; P = 0.001], and 10.7% [OR, 19.355; P = 0.004], respectively. Among the 153 HLA-B*58:01 carriers with chronic renal insufficiency (CRI), the incidence of SCARs doubled to 6.5% and further increased to 40%, 30%, and 37.5% in the presence of HLA-B75, DR13 homozygosity, or DR14, respectively.

Conclusion

Secondary screening with HLA-B75, DR13 homozygosity, and DR14 in addition to primary screening with HLA-B*58:01 would enable a more accurate prediction of SCAR occurrence, especially in patients with CRI.



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Sub-regional ‘other-accent’ effects on lay listeners’ speaker identification abilities: a voice line-up study with speakers and listeners from the North East of England

Previous studies have shown that listeners perform worse in speaker identification experiments when they are unfamiliar with the accents of the speakers. Such effects have been documented for listeners hearing unfamiliar foreign languages (language familiarity effect) and unfamiliar regional accents ('other-accent' effect). The present study investigates the 'other-accent' effect at a sub-regional level. Listeners from three different localities (Newcastle, Sunderland and Middlesbrough) within the same greater dialectal region (the North East of England) participated in one of three target-present voice line-ups using samples spoken by speakers from one of the three localities. Listeners who heard a voice line-up in their own local accent (ingroup listeners) missed the target speaker's voice significantly less often than listeners who heard a voice line-up comprised of speakers of one of the other two local accents (out-group listeners). The proportions of correct hits and false alarms were approximately similar across in-group and out-group listeners.



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Discourse processes and topic management in false confession contamination by police investigators

This article advances an analysis of discourse processes which produce confession contamination by two police investigators in an interrogation which resulted in a voluntary false confession. Specifically, I identify and exemplify processes which I call 'clueing', 'stacking', 'marking' and 'telling', which are recruited to both covertly and overtly disclose inside crime knowledge to an innocent suspect who is being questioned about such knowledge but is, of course, unable to supply it.


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Between-speaker rhythmic variability is not dependent on language rhythm, as evidence from Persian reveals

Acoustic measures of speech rhythm based on the durational characteristics of consonantal and vocalic intervals (henceforth C- or V-intervals) as well as syllabic intensity reveal between-speaker variability. The evidence obtained so far is based on speakers of stressed-timed languages, which are assumed to have complex consonant clusters and a higher degree of vowel reduction. Speakers of stressed-timed languages might operate their articulatory organs in different ways due to the syllable complexity and vowel reduction. Complex consonant clusters are released differently, and vowel reduction tends to be produced more or less strongly depending on speakers. When a language lacks such features, it is possible that rhythmic variation between its speakers decreases. In the present study, we aimed at exploring between- and within-speaker rhythmic variability in Persian, an Indo-European language categorised as syllable-timed. Acoustic correlates of speech rhythm (%V, ΔV[ln], ΔC[ln], n-PVI-V) and articulation rate were obtained from two Persian corpora with different sources of within-speaker variability. In the first corpus, the source of within-speaker variability mainly comes from non-contemporaneous recording sessions, and in the second corpus, from different speech rates. Results revealed that there were significant differences between speakers in all investigated speech rhythm measures in Persian and %V best discriminated between speakers. This reveals that the lack of typical stress-time features does not affect between-speaker variability in speech rhythm.



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Factors Associated with Dysfunctional Breathing in patients with Difficult to Treat Asthma

Publication date: Available online 7 December 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Eve Denton, Janet Bondarenko, TunnRen Tay, Joy Lee, Naghmeh Radhakrishna, Fiona Hore-Lacy, Catherine Martin, Ryan Hoy, Robyn O'Hehir, Eli Dabscheck, Mark Hew

Abstract
Background

Understanding of dysfunctional breathing in difficult asthma patients who remain symptomatic despite maximal inhaler therapy is limited.

Objective

We characterised the pattern of dysfunctional breathing in patients with difficult asthma and identified possible contributory factors.

Methods

Dysfunctional breathing was identified in patients with difficult asthma using the Nijmegen questionnaire (score >23). Demographics, asthma variables, and comorbidities were assessed. Multivariate logistic regression was performed for dysfunctional breathing, adjusted for age, sex, body mass index and airflow obstruction.

Results

Of 157 patients with difficult asthma, 73 (47%) had dysfunctional breathing. Compared to patients without dysfunctional breathing, those with dysfunctional breathing experienced poorer asthma status [symptom control, quality of life (QOL) and exacerbation rates] and greater unemployment. Additionally, more frequently they had elevated sino-nasal outcome test (SNOT-22) scores, anxiety, depression, sleep apnoea and gastroesophageal reflux. On multivariate analysis, anxiety (OR=3.26, 95%CI 1.18-9.01, p=0.02), depression (OR=2.8. 95%CI 1.14-6.9, p=0.03) and SNOT-22 (OR 1.03 95% CI 1.003-1.05, p=0.03) were independent risk factors for dysfunctional breathing.

Conclusion

Dysfunctional breathing is common in difficult asthma and associated with worse asthma status and unemployment. The independent association with psychological disorders and nasal obstruction highlight an important interaction between comorbid treatable traits in difficult asthma.



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Reduced final height and inadequate nutritional intake in cow’s milk-allergic young adults

Publication date: Available online 7 December 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): T. Sinai, M.R. Goldberg, L. Nachshon, R. Amitzur-Levy, T. Yichie, Y. Katz, E. Monsonego-Ornan, A. Elizur

Abstract
Background

Growth impairment was previously described in milk-allergic children but was not examined in adults upon reaching final height.

Objectives

To investigate the dietary intake and final stature of young adults with IgE-mediated cow's milk-allergy (IgE-CMA) as compared to non-allergic controls.

Methods

87 IgE-CMA patients, median age 19.5 years (IQR, 17.3-22.7) and 36 control participants without food allergies, median age 22.7 years (IQR, 18.9-26.1) were studied. Anthropometric and nutritional data were collected. Age- and gender z-scores were determined according to the Centers for Disease Control and Prevention growth charts. Nutrient intake assessment was based on dietary records. Individuals with conditions or treatments affecting bone metabolism or growth, other than asthma, were excluded.

Results

Mean values of height-z-scores were significantly reduced in CMA subjects compared to controls (-0.64±0.9 versus -0.04±0.7, p=0.001). In contrast, no differences were found between the two groups in weight- and BMI-z-scores. CMA patients had significantly lower intake of protein, and several essential vitamins (A, B12 and Riboflavin) and minerals (calcium, potassium, phosphorus, magnesium and zinc) compared to controls (p<0.05) but the intakes of calories, carbohydrate and fat were not significantly different between the two groups. Differences between actual and expected (based on mid-parental height) height-z-scores were comparable in CMA subjects with or without asthma and between those with and without additional food allergies.

Conclusion

Young adults who have cow's milk allergy from infancy are at risk of not reaching their growth potential. Growth and nutritional monitoring and appropriate dietary intervention are of particular importance in these at-risk individuals.



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Residual Fluticasone in the Oral Cavity after Inhalation with Different Tongue Positions

Publication date: Available online 7 December 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Tatsuyoshi Yokoi, Rieko Kondo, Takahiko Horiguchi



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Assessing Children’s Readiness to Carry and Use Quick-Relief Inhalers

Publication date: Available online 6 December 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Anna Volerman, Madeleine Toups, Ashley Hull, Margaret Dennin, Tae Yeon Kim, Stacy Ignoffo, Lisa K. Sharp, Valerie G. Press



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Treatment can be continued for mild cutaneous reactions associated with efavirenz

Publication date: Available online 6 December 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Thuraya Isaacs, Reginald Mduzumile Ngwanya, Sipho Dlamini, Jonny Peter, Rannakoe Lehloenya



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Spatial deconvolution of aerial radiometric survey and its application to the fallout from a radiological dispersal device

Publication date: February 2019

Source: Journal of Environmental Radioactivity, Volume 197

Author(s): Laurel E. Sinclair, Richard Fortin

Abstract

Mapping radioactive contamination using aerial survey measurements is an area under active investigation today. The radiometric aerial survey technique has been extensively applied following reactor accidents and also would provide a key tool for response to a malicious radiological or nuclear incident. Methods exist to calibrate the aerial survey system for quantification of the concentration of natural radionuclides, which can provide guidance. However, these methods have anticipated a spatial distribution of the source which is large in comparison to the survey altitude. In rapid emergency-response aerial surveys of areas of safety concern, deposits of relatively small spatial extent may be expected. The activity of such spatially restricted hot spots is underestimated using the traditional methods. We present here a spatial deconvolution method which can recover some of the variation smoothed out by the averaging due to survey at altitude. We show that the method can recover the true spatial distribution of concentration of a synthetic source. We then apply the method to real aerial survey data collected following detonation of a radiological dispersal device. The findings and implications of the deconvolution are then discussed by reference to a groundbased truckborne survey over the same contamination.



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Spatial deconvolution of aerial radiometric survey and its application to the fallout from a radiological dispersal device

Publication date: February 2019

Source: Journal of Environmental Radioactivity, Volume 197

Author(s): Laurel E. Sinclair, Richard Fortin

Abstract

Mapping radioactive contamination using aerial survey measurements is an area under active investigation today. The radiometric aerial survey technique has been extensively applied following reactor accidents and also would provide a key tool for response to a malicious radiological or nuclear incident. Methods exist to calibrate the aerial survey system for quantification of the concentration of natural radionuclides, which can provide guidance. However, these methods have anticipated a spatial distribution of the source which is large in comparison to the survey altitude. In rapid emergency-response aerial surveys of areas of safety concern, deposits of relatively small spatial extent may be expected. The activity of such spatially restricted hot spots is underestimated using the traditional methods. We present here a spatial deconvolution method which can recover some of the variation smoothed out by the averaging due to survey at altitude. We show that the method can recover the true spatial distribution of concentration of a synthetic source. We then apply the method to real aerial survey data collected following detonation of a radiological dispersal device. The findings and implications of the deconvolution are then discussed by reference to a groundbased truckborne survey over the same contamination.



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Cx±platinum–fluorouracil-based chemotherapy in head and neck CA | European Archives of Oto-Rhino-Laryngology - MD Linx

Cx±platinum–fluorouracil-based chemotherapy in head and neck CA | European Archives of Oto-Rhino-Laryngology  MD Linx

Otolaryngology Article: Benefit of cetuximab addition to a platinum–fluorouracil-based chemotherapy according to KRAS-LCS6 variant in an unselected ...



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Head and Neck Cancer Diagnostics Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2023 - The Smyrna Themes

image.png

Head and Neck Cancer Diagnostics Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2023  The Smyrna Themes

The Head and Neck Cancer Diagnostics Market report evaluates the important characteristics of the Head and Neck Cancer Diagnostics market based on ...



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AstraZeneca: EAGLE Trial With Imfinzi & Tremelimumab Fails To Meet Endpoints - Markets Insider

AstraZeneca: EAGLE Trial With Imfinzi & Tremelimumab Fails To Meet Endpoints  Markets Insider

(RTTNews) - AstraZeneca (AZN.L, AZN) and MedImmune, its global biologics research and development arm, announced overall survival results for the Phase ...



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Squamous Cell Carcinoma of the Head and Neck Treatment Market Size, Demand, Outlook, Growth, Driving Players and Industry Analysis Report 2025 - Tribune Updates

Squamous Cell Carcinoma of the Head and Neck Treatment Market Size, Demand, Outlook, Growth, Driving Players and Industry Analysis Report 2025  Tribune Updates

Head and neck cancer usually occurs in the squamous cells present inside the mouth, nose and throat. These squamous cells are usually known as squamous ...



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Head and Neck Cancer Diagnostics Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2023 - The Smyrna Themes

image.png

Head and Neck Cancer Diagnostics Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2023  The Smyrna Themes

The Head and Neck Cancer Diagnostics Market report evaluates the important characteristics of the Head and Neck Cancer Diagnostics market based on ...



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Squamous Cell Carcinoma of the Head and Neck Treatment Market Size, Demand, Outlook, Growth, Driving Players and Industry Analysis Report 2025 - Tribune Updates

Squamous Cell Carcinoma of the Head and Neck Treatment Market Size, Demand, Outlook, Growth, Driving Players and Industry Analysis Report 2025  Tribune Updates

Head and neck cancer usually occurs in the squamous cells present inside the mouth, nose and throat. These squamous cells are usually known as squamous ...



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Cx±platinum–fluorouracil-based chemotherapy in head and neck CA | European Archives of Oto-Rhino-Laryngology - MD Linx

Cx±platinum–fluorouracil-based chemotherapy in head and neck CA | European Archives of Oto-Rhino-Laryngology  MD Linx

Otolaryngology Article: Benefit of cetuximab addition to a platinum–fluorouracil-based chemotherapy according to KRAS-LCS6 variant in an unselected ...



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AstraZeneca: EAGLE Trial With Imfinzi & Tremelimumab Fails To Meet Endpoints - Markets Insider

AstraZeneca: EAGLE Trial With Imfinzi & Tremelimumab Fails To Meet Endpoints  Markets Insider

(RTTNews) - AstraZeneca (AZN.L, AZN) and MedImmune, its global biologics research and development arm, announced overall survival results for the Phase ...



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Wide diameter bone-anchored hearing system implants: a comparison of long-term follow-up data between tissue reduction and tissue preservation techniques

Abstract

Objective

To present long-term data on the Wide Ponto implant bone-anchored hearing system (BAHS) in regards to implant stability, soft tissue reaction and implant loss for two case series undergone either the tissue reduction- or the tissue preservation surgical technique.

Methods

Comparison of two consecutive, prospective case series. Each case series enrolled 24 patients. The case series underwent one-stage implantation of the Wide Ponto implant BAHS using either a linear incision technique with subcutaneous reduction or a linear incision technique without subcutaneous reduction. Implant stability quotient (ISQ) values were measured using resonance frequency analysis and soft tissue reactions were graded according to Holgers' classification system. Follow-up visits were performed at 10 days, 6 weeks, 6 months, 12 months and annually up to 4 years (tissue preservation) or 5 years (tissue reduction) postoperatively.

Results

The two case series had homogenous patient populations and followed an identical postoperative scheme. The ISQ values increased consistently the first 12 months for both groups (p ≤ 0.001), and were higher in the tissue preservation case series, (p = 0.04, 9 mm abutment). More than 91% of the soft tissue observations were assessed as Holgers' grade 0 or 1. One implant (2.1%) was lost due to trauma.

Conclusion

In both case series, the Wide Ponto implant showed increasing implant stability during the follow-up period from the time of surgery, irrespective of surgical technique, indicating good osseointegration. Soft tissue reactions were rare and of minor severity. Implant survival was high.



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The Role of Flexible Bronchoscopy Accomplished Through a Laryngeal Mask Airway in the Treatment of Tracheobronchial Foreign Bodies in Children

Publication date: Available online 6 December 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Alev Suzen, Suleyman Cuneyt Karakus, Nazile Erturk

Abstract
Introduction

We here present our experience with children who underwent flexible bronchoscopy for removal of inhaled tracheobronchial foreign bodies under general anesthesia via a laryngeal mask airway (LMA).

Materials and Methods

A total of 24 (16 male and 8 female, mean age: 30.75±29.68 months) patients who underwent flexible bronchoscopy under general anesthesia using a LMA for suspicion of tracheobronchial foreign bodies between July 2016 and April 2018 were retrospectively reviewed.

Results

The mean duration of admission to hospital was 162.56±309.56 hours. Sixteen (66.7%) patients were found to have tracheobronchial foreign bodies. All procedures were successfully accomplished through a LMA by using basket forceps, a Fogarty catheter and a suction without any need for rigid bronchoscopy. 11 (68.7%) of tracheobronchial foreign body locations were right bronchial, 3 (18.8%) were left bronchial and 2 (12.5%) were tracheal. The types of extracted tracheobronchial foreign bodies were organic in 14 (87.5%) and non-organic in 2 (12.5 %). There were no complications except laryngeal edema noted in 2 (8.3%) patients, relieved within 48 hours. The mean time of postoperative hospitalisation was 2.42±0.97 days.

Conclusion

Flexible bronchoscopy accomplished through a LMA is a safe, easy and effective technique, not only as a diagnostic procedure, but also as the initial therapeutic modality for retrieving tracheobronchial foreign bodies in children with high success and low complication rates. With further reports aforementioned, we hope that the flexible bronchoscopy will become a standard method in children.



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Feeding Practices and Growth of Infants with Pierre Robin Sequence

Publication date: Available online 7 December 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Bonnie Dorise, Amit Trivedi, Claire Galea, Karen Walker, Bhavesh Mehta

Abstract
Objectives

To assess the impact of feeding practices on growth in infants with Pierre Robin Sequence (PRS) during their inpatient stay in a neonatal intensive care unit in a large tertiary paediatric hospital setting.

Methods

A retrospective review of feeding practices in infants with PRS was conducted between January 2006 and September 2017. Baseline demographics, nutrition-related and general outcomes were collected. Feeding difficulties, length of stay (LOS) and malnutrition were the primary outcome measures. Feeding difficulties included absence or poor-quality suck, episodes of aspiration, use of proton pump inhibitors or multiple episodes of vomiting. Malnutrition was classified as a weight-for-age Z score of <-1.

Results

Analysis was conducted on 49 infants with PRS that met eligibility criteria. Feeding difficulties correlated with a longer LOS (24.1 vs 6.8 days (p=0.001)) Z-scores differed significantly between birth and discharge (0.21(1.84) vs -1.27(2.14)) (p<0.001*) with malnutrition being evident in 26 infants of which only 17 infants were seen by a dietitian. Presence of intrauterine growth restriction (IUGR) increased the likelihood of malnutrition (OR 1.40(CI-1.11-1.77)).

Conclusion

Infants with PRS are highly likely to have feeding difficulties and malnutrition. Early intervention by a dietitian is recommended to reduce the impacts of feeding difficulties, meet elevated energy requirements and facilitate growth. Infants with a longer inpatient stay or presence of IUGR should have their growth and feeding routinely monitored.



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Wide diameter bone-anchored hearing system implants: a comparison of long-term follow-up data between tissue reduction and tissue preservation techniques

Abstract

Objective

To present long-term data on the Wide Ponto implant bone-anchored hearing system (BAHS) in regards to implant stability, soft tissue reaction and implant loss for two case series undergone either the tissue reduction- or the tissue preservation surgical technique.

Methods

Comparison of two consecutive, prospective case series. Each case series enrolled 24 patients. The case series underwent one-stage implantation of the Wide Ponto implant BAHS using either a linear incision technique with subcutaneous reduction or a linear incision technique without subcutaneous reduction. Implant stability quotient (ISQ) values were measured using resonance frequency analysis and soft tissue reactions were graded according to Holgers' classification system. Follow-up visits were performed at 10 days, 6 weeks, 6 months, 12 months and annually up to 4 years (tissue preservation) or 5 years (tissue reduction) postoperatively.

Results

The two case series had homogenous patient populations and followed an identical postoperative scheme. The ISQ values increased consistently the first 12 months for both groups (p ≤ 0.001), and were higher in the tissue preservation case series, (p = 0.04, 9 mm abutment). More than 91% of the soft tissue observations were assessed as Holgers' grade 0 or 1. One implant (2.1%) was lost due to trauma.

Conclusion

In both case series, the Wide Ponto implant showed increasing implant stability during the follow-up period from the time of surgery, irrespective of surgical technique, indicating good osseointegration. Soft tissue reactions were rare and of minor severity. Implant survival was high.



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The Role of Flexible Bronchoscopy Accomplished Through a Laryngeal Mask Airway in the Treatment of Tracheobronchial Foreign Bodies in Children

Publication date: Available online 6 December 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Alev Suzen, Suleyman Cuneyt Karakus, Nazile Erturk

Abstract
Introduction

We here present our experience with children who underwent flexible bronchoscopy for removal of inhaled tracheobronchial foreign bodies under general anesthesia via a laryngeal mask airway (LMA).

Materials and Methods

A total of 24 (16 male and 8 female, mean age: 30.75±29.68 months) patients who underwent flexible bronchoscopy under general anesthesia using a LMA for suspicion of tracheobronchial foreign bodies between July 2016 and April 2018 were retrospectively reviewed.

Results

The mean duration of admission to hospital was 162.56±309.56 hours. Sixteen (66.7%) patients were found to have tracheobronchial foreign bodies. All procedures were successfully accomplished through a LMA by using basket forceps, a Fogarty catheter and a suction without any need for rigid bronchoscopy. 11 (68.7%) of tracheobronchial foreign body locations were right bronchial, 3 (18.8%) were left bronchial and 2 (12.5%) were tracheal. The types of extracted tracheobronchial foreign bodies were organic in 14 (87.5%) and non-organic in 2 (12.5 %). There were no complications except laryngeal edema noted in 2 (8.3%) patients, relieved within 48 hours. The mean time of postoperative hospitalisation was 2.42±0.97 days.

Conclusion

Flexible bronchoscopy accomplished through a LMA is a safe, easy and effective technique, not only as a diagnostic procedure, but also as the initial therapeutic modality for retrieving tracheobronchial foreign bodies in children with high success and low complication rates. With further reports aforementioned, we hope that the flexible bronchoscopy will become a standard method in children.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BVOgc9

Feeding Practices and Growth of Infants with Pierre Robin Sequence

Publication date: Available online 7 December 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Bonnie Dorise, Amit Trivedi, Claire Galea, Karen Walker, Bhavesh Mehta

Abstract
Objectives

To assess the impact of feeding practices on growth in infants with Pierre Robin Sequence (PRS) during their inpatient stay in a neonatal intensive care unit in a large tertiary paediatric hospital setting.

Methods

A retrospective review of feeding practices in infants with PRS was conducted between January 2006 and September 2017. Baseline demographics, nutrition-related and general outcomes were collected. Feeding difficulties, length of stay (LOS) and malnutrition were the primary outcome measures. Feeding difficulties included absence or poor-quality suck, episodes of aspiration, use of proton pump inhibitors or multiple episodes of vomiting. Malnutrition was classified as a weight-for-age Z score of <-1.

Results

Analysis was conducted on 49 infants with PRS that met eligibility criteria. Feeding difficulties correlated with a longer LOS (24.1 vs 6.8 days (p=0.001)) Z-scores differed significantly between birth and discharge (0.21(1.84) vs -1.27(2.14)) (p<0.001*) with malnutrition being evident in 26 infants of which only 17 infants were seen by a dietitian. Presence of intrauterine growth restriction (IUGR) increased the likelihood of malnutrition (OR 1.40(CI-1.11-1.77)).

Conclusion

Infants with PRS are highly likely to have feeding difficulties and malnutrition. Early intervention by a dietitian is recommended to reduce the impacts of feeding difficulties, meet elevated energy requirements and facilitate growth. Infants with a longer inpatient stay or presence of IUGR should have their growth and feeding routinely monitored.



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Quantitative analysis of carotid arterial calcification using airway CT in obstructive sleep apnea

Publication date: Available online 7 December 2018

Source: Auris Nasus Larynx

Author(s): Tae Kyung Koh, Eun-Ju Kang, Woo Yong Bae, Sung Wan Kim, Chul Hoon Kim, Soo Kweon Koo, Sang Jun Kim, Moon Sung Kim, Jae Hoon Lee

Abstract
Objective

To evaluate the relationship between obstructive sleep apnea (OSA) severity and carotid arterial calcification by quantitative analysis using airway computed tomography (CT).

Methods

This study included a total of 180 consecutive OSA patients aged 45–80 years underwent polysomnography and airway CT between March 2014 and October 2016. The subjects were divided into three groups based on the results of the respiratory disturbance index (RDI): mild (RDI 5–14, n = 29), moderate (RDI 15–29, n = 50), and severe (RDI ≥ 30, n = 101). The extent of carotid arterial calcification on each airway CT scan was quantified according to the modified Agatston scoring method. Differences among the three groups in clinical characteristics including age, gender, body mass index (BMI), comorbid disease, blood pressure, total cholesterol, and carotid arterial calcification score (CarACS) were analyzed.

Results

The severe OSA group showed significantly stronger predominance for male and smoker, higher prevalence of diabetes, and larger BMI than those of mild and moderate OSA groups. The mean CarACS was significantly different among the three groups (mild RDI: 4.3 ± 13.4, moderate RDI: 7.4 ± 28.8, severe RDI: 48.6 ± 121.6, P = 0.011). Univariate linear regression showed that RDI, age, hypertension, male sex and diabetes significantly influenced on the CarACS. In a multivariate linear regression model, the CarACS was related to age, male sex, and diabetes.

Conclusions

The patients with severe OSA showed larger CarACS and a higher prevalence of atherosclerotic risk factors. The CarACS was correlated with severity of OSA, which might be more dependent on the conventional risk factors of atherosclerosis.



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Quantitative analysis of carotid arterial calcification using airway CT in obstructive sleep apnea

Publication date: Available online 7 December 2018

Source: Auris Nasus Larynx

Author(s): Tae Kyung Koh, Eun-Ju Kang, Woo Yong Bae, Sung Wan Kim, Chul Hoon Kim, Soo Kweon Koo, Sang Jun Kim, Moon Sung Kim, Jae Hoon Lee

Abstract
Objective

To evaluate the relationship between obstructive sleep apnea (OSA) severity and carotid arterial calcification by quantitative analysis using airway computed tomography (CT).

Methods

This study included a total of 180 consecutive OSA patients aged 45–80 years underwent polysomnography and airway CT between March 2014 and October 2016. The subjects were divided into three groups based on the results of the respiratory disturbance index (RDI): mild (RDI 5–14, n = 29), moderate (RDI 15–29, n = 50), and severe (RDI ≥ 30, n = 101). The extent of carotid arterial calcification on each airway CT scan was quantified according to the modified Agatston scoring method. Differences among the three groups in clinical characteristics including age, gender, body mass index (BMI), comorbid disease, blood pressure, total cholesterol, and carotid arterial calcification score (CarACS) were analyzed.

Results

The severe OSA group showed significantly stronger predominance for male and smoker, higher prevalence of diabetes, and larger BMI than those of mild and moderate OSA groups. The mean CarACS was significantly different among the three groups (mild RDI: 4.3 ± 13.4, moderate RDI: 7.4 ± 28.8, severe RDI: 48.6 ± 121.6, P = 0.011). Univariate linear regression showed that RDI, age, hypertension, male sex and diabetes significantly influenced on the CarACS. In a multivariate linear regression model, the CarACS was related to age, male sex, and diabetes.

Conclusions

The patients with severe OSA showed larger CarACS and a higher prevalence of atherosclerotic risk factors. The CarACS was correlated with severity of OSA, which might be more dependent on the conventional risk factors of atherosclerosis.



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Whole genome and transcriptome profiling of a metastatic thyroid-like follicular renal cell carcinoma - UroToday

Whole genome and transcriptome profiling of a metastatic thyroid-like follicular renal cell carcinoma  UroToday

Thyroid-like follicular renal cell carcinoma (TLFRCC) is a rare cancer with few reports of metastatic disease. Little is known regarding genomic characteristics ...



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Interpace Diagnostics Group (NASDAQ:IDXG) Issues Quarterly Earnings Results, Misses Estimates By $0.04 EPS - Fairfield Current

pdi-logo.jpg

Interpace Diagnostics Group (NASDAQ:IDXG) Issues Quarterly Earnings Results, Misses Estimates By $0.04 EPS  Fairfield Current

Interpace Diagnostics Group (NASDAQ:IDXG) released its quarterly earnings results on Tuesday, November 13th. The business services provider reported ...



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HSBC Reiterates €85.00 Price Target for Merck KGaA (FRA:MRK) - Fairfield Current

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HSBC Reiterates €85.00 Price Target for Merck KGaA (FRA:MRK)  Fairfield Current

Merck KGaA (FRA:MRK) has been given a €85.00 ($98.84) price target by research analysts at HSBC in a research note issued to investors on Wednesday, ...



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Brokerages Set Exelixis, Inc. (EXEL) Target Price at $29.44 - Fairfield Current

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Brokerages Set Exelixis, Inc. (EXEL) Target Price at $29.44  Fairfield Current

Shares of Exelixis, Inc. (NASDAQ:EXEL) have been assigned an average recommendation of "Buy" from the fifteen ratings firms that are covering the company, ...



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AMC passes on endoscopic thyroidectomy know-how to Myanmar - Korea Biomedical Review

4566_4699_1215.jpg

AMC passes on endoscopic thyroidectomy know-how to Myanmar  Korea Biomedical Review

Asan Medical Center (AMC)'s endocrine surgeons Sung Tae-yeon and Kim Won-woong handed down the skills of "underarm endoscopic thyroidectomy" to ...



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HSBC Reiterates €85.00 Price Target for Merck KGaA (FRA:MRK) - Fairfield Current

merck-kgaa-logo.JPG

HSBC Reiterates €85.00 Price Target for Merck KGaA (FRA:MRK)  Fairfield Current

Merck KGaA (FRA:MRK) has been given a €85.00 ($98.84) price target by research analysts at HSBC in a research note issued to investors on Wednesday, ...



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Brokerages Set Exelixis, Inc. (EXEL) Target Price at $29.44 - Fairfield Current

exelixis-inc-logo.gif

Brokerages Set Exelixis, Inc. (EXEL) Target Price at $29.44  Fairfield Current

Shares of Exelixis, Inc. (NASDAQ:EXEL) have been assigned an average recommendation of "Buy" from the fifteen ratings firms that are covering the company, ...



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Interpace Diagnostics Group (NASDAQ:IDXG) Issues Quarterly Earnings Results, Misses Estimates By $0.04 EPS - Fairfield Current

pdi-logo.jpg

Interpace Diagnostics Group (NASDAQ:IDXG) Issues Quarterly Earnings Results, Misses Estimates By $0.04 EPS  Fairfield Current

Interpace Diagnostics Group (NASDAQ:IDXG) released its quarterly earnings results on Tuesday, November 13th. The business services provider reported ...



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Whole genome and transcriptome profiling of a metastatic thyroid-like follicular renal cell carcinoma - UroToday

Whole genome and transcriptome profiling of a metastatic thyroid-like follicular renal cell carcinoma  UroToday

Thyroid-like follicular renal cell carcinoma (TLFRCC) is a rare cancer with few reports of metastatic disease. Little is known regarding genomic characteristics ...



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AMC passes on endoscopic thyroidectomy know-how to Myanmar - Korea Biomedical Review

4566_4699_1215.jpg

AMC passes on endoscopic thyroidectomy know-how to Myanmar  Korea Biomedical Review

Asan Medical Center (AMC)'s endocrine surgeons Sung Tae-yeon and Kim Won-woong handed down the skills of "underarm endoscopic thyroidectomy" to ...



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Comparative microbiome analysis of Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae

Publication date: Available online 6 December 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Jinyoung Lee, Ju Yeong Kim, Myung-hee Yi, Younjee Hwang, In-Yong Lee, Sung-Hyun Nam, Dongeun Yong, Tai-Soon Yong



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Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology

Publication date: Available online 6 December 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Melody C. Carter, Dean D. Metcalfe, Almudena Matito, Luis Escribano, Joseph H. Butterfield, Lawrence B. Schwartz, Patrizia Bonadonna, Roberta Zanotti, Massimo Triggiani, Mariana Castells, Knut Brockow

Abstract

Providers caring for patients with mastocytosis are tasked with the decision to consider therapeutic options. This may come with some trepidation since the information available in the public domain lists numerous mast cell activators based on data that does not discriminate between primates, rodents and mast cell lines, does not consider dosage and does not take into account previous exposure and resultant clinical findings. This being said, there is support in the literature for an enhanced mast cell response in some patients with mastocytosis and where there is higher incidence of adverse reactions associated with certain antigens such as venoms as well as drugs. This report thus provides a comprehensive guide for those providers who must decide on therapeutic options in the management of patients with clonal mast cell disease.



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Staphylococcus aureus, epithelial disruption and nasal polyps. Are we one step ahead in combatting this foe?

Publication date: Available online 6 December 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Mahboobeh Mahdavinia, Pete S. Batra



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Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology

Publication date: Available online 6 December 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Melody C. Carter, Dean D. Metcalfe, Almudena Matito, Luis Escribano, Joseph H. Butterfield, Lawrence B. Schwartz, Patrizia Bonadonna, Roberta Zanotti, Massimo Triggiani, Mariana Castells, Knut Brockow

Abstract

Providers caring for patients with mastocytosis are tasked with the decision to consider therapeutic options. This may come with some trepidation since the information available in the public domain lists numerous mast cell activators based on data that does not discriminate between primates, rodents and mast cell lines, does not consider dosage and does not take into account previous exposure and resultant clinical findings. This being said, there is support in the literature for an enhanced mast cell response in some patients with mastocytosis and where there is higher incidence of adverse reactions associated with certain antigens such as venoms as well as drugs. This report thus provides a comprehensive guide for those providers who must decide on therapeutic options in the management of patients with clonal mast cell disease.



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Staphylococcus aureus, epithelial disruption and nasal polyps. Are we one step ahead in combatting this foe?

Publication date: Available online 6 December 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Mahboobeh Mahdavinia, Pete S. Batra



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Comparative microbiome analysis of Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae

Publication date: Available online 6 December 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Jinyoung Lee, Ju Yeong Kim, Myung-hee Yi, Younjee Hwang, In-Yong Lee, Sung-Hyun Nam, Dongeun Yong, Tai-Soon Yong



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UK Veterinary Orthopedic Implants Market, Veterinary Orthopedic Implants Market Forecast, Veterinary Orthopedic Implants Industry Analysis, Veterinary Orthopedic Implants Industry Assessment, Veterinary Orthopedic Implants Industry, Veterinary Orthopedic Implants Market Report, Veterinary Orthopedic Implants Market Trends, Veterinary Orthopedic Implants Market Share, Veterinary Orthopedic Implants Market Size, Veterinary Orthopedic Implants Market Outlook, Veterinary Orthopedic Implants Market Re

UK Veterinary Orthopedic Implants Market, Veterinary Orthopedic Implants Market Forecast, Veterinary Orthopedic Implants Industry Analysis, Veterinary Orthopedic Implants Industry Assessment, Veterinary Orthopedic Implants Industry, Veterinary Orthopedic Implants Market Report, Veterinary Orthopedic Implants Market Trends, Veterinary Orthopedic Implants Market Share, Veterinary Orthopedic Implants Market Size, Veterinary Orthopedic Implants Market Outlook, Veterinary Orthopedic Implants Market Research Report, Veterinary Orthopedic Implants Market Growth  The Future Gadgets

Coherent Market Insights released a new market study on 2018-2026 Hypopharyngeal Cancer Treatment Market with 100+ market data Tables, Pie Chat, ...



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Recovernow: A Multicentre Of Tablet-Based Speech Therapy For Post-Stroke Aphasia

Condition:   Stroke Sequelae Interventions:   Other: Speech therapy apps;   Other: Non-speech therapy apps Sponsor:   Ottawa Hospital Research Institute Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



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Risking the unknown in hope of a cure: The ethics of patient access to experimental treatments - EurekAlert

Risking the unknown in hope of a cure: The ethics of patient access to experimental treatments  EurekAlert

The Nuffield Council on Bioethics has today published a new briefing note highlighting the ethical issues that can arise when patients and doctors wish to use ...



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UK Veterinary Orthopedic Implants Market, Veterinary Orthopedic Implants Market Forecast, Veterinary Orthopedic Implants Industry Analysis, Veterinary Orthopedic Implants Industry Assessment, Veterinary Orthopedic Implants Industry, Veterinary Orthopedic Implants Market Report, Veterinary Orthopedic Implants Market Trends, Veterinary Orthopedic Implants Market Share, Veterinary Orthopedic Implants Market Size, Veterinary Orthopedic Implants Market Outlook, Veterinary Orthopedic Implants Market Re

UK Veterinary Orthopedic Implants Market, Veterinary Orthopedic Implants Market Forecast, Veterinary Orthopedic Implants Industry Analysis, Veterinary Orthopedic Implants Industry Assessment, Veterinary Orthopedic Implants Industry, Veterinary Orthopedic Implants Market Report, Veterinary Orthopedic Implants Market Trends, Veterinary Orthopedic Implants Market Share, Veterinary Orthopedic Implants Market Size, Veterinary Orthopedic Implants Market Outlook, Veterinary Orthopedic Implants Market Research Report, Veterinary Orthopedic Implants Market Growth  The Future Gadgets

Coherent Market Insights released a new market study on 2018-2026 Hypopharyngeal Cancer Treatment Market with 100+ market data Tables, Pie Chat, ...



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Recovernow: A Multicentre Of Tablet-Based Speech Therapy For Post-Stroke Aphasia

Condition:   Stroke Sequelae Interventions:   Other: Speech therapy apps;   Other: Non-speech therapy apps Sponsor:   Ottawa Hospital Research Institute Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



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Risking the unknown in hope of a cure: The ethics of patient access to experimental treatments - EurekAlert

Risking the unknown in hope of a cure: The ethics of patient access to experimental treatments  EurekAlert

The Nuffield Council on Bioethics has today published a new briefing note highlighting the ethical issues that can arise when patients and doctors wish to use ...



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Periocular Manifestations of Afatinib Therapy

Epidermal growth factor receptor tyrosine kinase inhibitor therapy has been increasingly employed in the treatment of a variety of tumors. The authors report the rarely documented side effect of trichiasis with the use of Afatinib in a patient with spinal chordoma and review-related literature. A 67-year-old lady was referred to the oculoplastic service with a 3-month history of ocular irritation and pain associated with blurred vision. She has a 4-year history of spinal chordoma treated with daily Afatinib 50 mg over the past 6 months. Clinical examination revealed trichomegaly and trichiasis affecting all 4 eyelids associated with blepharitis, conjunctival, and corneal abrasion on fluorescein staining. Hypertrichosis of the eyebrow bilaterally was also present. Afatinib and other epidermal growth factor receptor tyrosine kinase inhibitor–associated changes to eyelash and eyebrow hair is a result of epidermal growth factor receptor pathway activation in keratinocytes results in remodeling of the hair follicle. This results in the variation in the severity of clinical presentation of trichiasis. Accepted for publication October 2, 2018. The authors have no financial or conflicts of interest to disclose. Photographs were performed with the subject's written informed consent for publication and are stored as part of Oxford University Hospitals NHS Trusts records. No IRB and completion of this case report and related research adhered to the tenets of the Declaration of Helsinki as amended in 2008. Address correspondence and reprint requests to Varajini Joganathan, M.Sc., F.R.C.Ophth., F.E.B.O., Oxford University Hospitals, Headley Way, Headington, Oxford OX3 9DU, United Kingdom. E-mail: v.joganathan@doctors.org.uk. © 2018 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.

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Periocular Manifestations of Afatinib Therapy

Epidermal growth factor receptor tyrosine kinase inhibitor therapy has been increasingly employed in the treatment of a variety of tumors. The authors report the rarely documented side effect of trichiasis with the use of Afatinib in a patient with spinal chordoma and review-related literature. A 67-year-old lady was referred to the oculoplastic service with a 3-month history of ocular irritation and pain associated with blurred vision. She has a 4-year history of spinal chordoma treated with daily Afatinib 50 mg over the past 6 months. Clinical examination revealed trichomegaly and trichiasis affecting all 4 eyelids associated with blepharitis, conjunctival, and corneal abrasion on fluorescein staining. Hypertrichosis of the eyebrow bilaterally was also present. Afatinib and other epidermal growth factor receptor tyrosine kinase inhibitor–associated changes to eyelash and eyebrow hair is a result of epidermal growth factor receptor pathway activation in keratinocytes results in remodeling of the hair follicle. This results in the variation in the severity of clinical presentation of trichiasis. Accepted for publication October 2, 2018. The authors have no financial or conflicts of interest to disclose. Photographs were performed with the subject's written informed consent for publication and are stored as part of Oxford University Hospitals NHS Trusts records. No IRB and completion of this case report and related research adhered to the tenets of the Declaration of Helsinki as amended in 2008. Address correspondence and reprint requests to Varajini Joganathan, M.Sc., F.R.C.Ophth., F.E.B.O., Oxford University Hospitals, Headley Way, Headington, Oxford OX3 9DU, United Kingdom. E-mail: v.joganathan@doctors.org.uk. © 2018 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.

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Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions

Abstract

Peripheral nerve sheath tumors (PNSTs) account for ~ 5% of soft tissue neoplasms and are responsible for a wide spectrum of morbidities ranging from localized neuropathy to fulminant metastatic spread and death. MR imaging represents the gold standard for identification of these neoplasms, however, current anatomic MR imaging markers do not reliably detect or differentiate benign and malignant lesions, and therefore, biopsy or excision is required for definitive diagnosis. Diffusion-weighted MR imaging (DWI) serves as a useful tool in the evaluation and management of PNSTs by providing functional information regarding the degree of diffusion, while diffusion tensor imaging (DTI) aids in determining the directional information of predominant diffusion and has been shown to be particularly useful for pre-operative planning of these tumors by delineating healthy and pathologic fascicles. The article focuses on these important neurogenic lesions, highlighting the current utility of diffusion MR imaging and future directions including computerized radiomic analysis.

Key Points

• Anatomic MRI is moderately accurate in differentiating benign from malignant PNST.

• Diffusion tensor imaging facilitates pre-operative planning of PNSTs by depicting neuropathy and tractography.

• Radiomics will likely augment current observer-based diagnostic criteria for PNSTs.



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Anti-inflammatory and anti-remodeling effects of myrtenol in the lungs of asthmatic rats: Histopathological and biochemical findings

Publication date: Available online 6 December 2018

Source: Allergologia et Immunopathologia

Author(s): M.A. Bejeshk, M. Samareh Fekri, H. Najafipour, F. Rostamzadeh, E. Jafari, M.A. Rajizadeh, Y. Masoumi-Ardakani

Abstract
Introduction

Asthma is a chronic inflammatory disease of the airways. In this study, we evaluated the anti-inflammatory effects of myrtenol on the inflammatory indices in the pulmonary parenchyma and airways and on the inflammatory and oxidative indices of the bronchoalveolar lavage fluid (BALF) of asthmatic rats.

Methods

The allergic asthma was induced by sensitization (two weeks) followed by the inhalation of ovalbumin (four weeks). Animals were divided into two main groups: (1) Histopathology, and (2) measurement of inflammatory and oxidative biomarkers in the BALF. Each main group was subdivided into four subgroups: Control, Asthma, Asthma + Dexamethasone and Asthma + Myrtenol. (−)-Myrtenol (50 mg/kg) or Dexamethasone (2.5 mg/kg) was administered intraperitoneally once a day for one week, at the end of the inhalation period. On day 50, lung histopathologic parameters and inflammatory indices in BALF including INF-γ, IL-10, IL-1β, and TNF-α and oxidative stress biomarkers (MDA, SOD, and GPX) were measured.

Result

In the Asthma group, leukocyte infiltration, the thickness of smooth muscle and epithelium of airways wall and the number of goblet cells increased. Myrtenol reduced all of the above-mentioned indices except the epithelium thickness. It also inhibited the increase in BALF IL-1β, TNF-α and MDA and increased the levels of INF-γ, IL-10 and SOD.

Conclusion

Our results suggest that myrtenol reduced damage caused by experimental asthma by reducing the inflammatory indices, normalizing the level of interleukins and balancing oxidative stress in the lungs. It also prevented airway remodeling. Myrtenol may be suggested as a potent herbal medicine for the treatment of allergic asthma.



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Anti-inflammatory and anti-remodeling effects of myrtenol in the lungs of asthmatic rats: Histopathological and biochemical findings

Publication date: Available online 6 December 2018

Source: Allergologia et Immunopathologia

Author(s): M.A. Bejeshk, M. Samareh Fekri, H. Najafipour, F. Rostamzadeh, E. Jafari, M.A. Rajizadeh, Y. Masoumi-Ardakani

Abstract
Introduction

Asthma is a chronic inflammatory disease of the airways. In this study, we evaluated the anti-inflammatory effects of myrtenol on the inflammatory indices in the pulmonary parenchyma and airways and on the inflammatory and oxidative indices of the bronchoalveolar lavage fluid (BALF) of asthmatic rats.

Methods

The allergic asthma was induced by sensitization (two weeks) followed by the inhalation of ovalbumin (four weeks). Animals were divided into two main groups: (1) Histopathology, and (2) measurement of inflammatory and oxidative biomarkers in the BALF. Each main group was subdivided into four subgroups: Control, Asthma, Asthma + Dexamethasone and Asthma + Myrtenol. (−)-Myrtenol (50 mg/kg) or Dexamethasone (2.5 mg/kg) was administered intraperitoneally once a day for one week, at the end of the inhalation period. On day 50, lung histopathologic parameters and inflammatory indices in BALF including INF-γ, IL-10, IL-1β, and TNF-α and oxidative stress biomarkers (MDA, SOD, and GPX) were measured.

Result

In the Asthma group, leukocyte infiltration, the thickness of smooth muscle and epithelium of airways wall and the number of goblet cells increased. Myrtenol reduced all of the above-mentioned indices except the epithelium thickness. It also inhibited the increase in BALF IL-1β, TNF-α and MDA and increased the levels of INF-γ, IL-10 and SOD.

Conclusion

Our results suggest that myrtenol reduced damage caused by experimental asthma by reducing the inflammatory indices, normalizing the level of interleukins and balancing oxidative stress in the lungs. It also prevented airway remodeling. Myrtenol may be suggested as a potent herbal medicine for the treatment of allergic asthma.



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Identification and prospective stability of eNose derived inflammatory phenotypes in severe asthma

We have identified and followed-up exhaled molecular phenotypes of severe asthma, which were associated with changing inflammatory profile and oral steroid usage. This suggests that breath analysis might contribute to the management of severe asthma.

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Comparative microbiome analysis of Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae

Three species of house dust mites, Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae, showed distinct microbiomes, which may affect the induction of allergic diseases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EfjEoc

Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology

Providers caring for patients with mastocytosis are tasked with the decision to consider therapeutic options. This may come with some trepidation since the information available in the public domain lists numerous mast cell activators based on data that does not discriminate between primates, rodents and mast cell lines, does not consider dosage and does not take into account previous exposure and resultant clinical findings. This being said, there is support in the literature for an enhanced mast cell response in some patients with mastocytosis and where there is higher incidence of adverse reactions associated with certain antigens such as venoms as well as drugs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E5TLGD

Staphylococcus aureus, epithelial disruption and nasal polyps. Are we one step ahead in combatting this foe?



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E3IpTA

Comparative microbiome analysis of Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae

Three species of house dust mites, Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae, showed distinct microbiomes, which may affect the induction of allergic diseases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EfjEoc

Staphylococcus aureus, epithelial disruption and nasal polyps. Are we one step ahead in combatting this foe?



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E3IpTA

Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology

Providers caring for patients with mastocytosis are tasked with the decision to consider therapeutic options. This may come with some trepidation since the information available in the public domain lists numerous mast cell activators based on data that does not discriminate between primates, rodents and mast cell lines, does not consider dosage and does not take into account previous exposure and resultant clinical findings. This being said, there is support in the literature for an enhanced mast cell response in some patients with mastocytosis and where there is higher incidence of adverse reactions associated with certain antigens such as venoms as well as drugs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E5TLGD

Identification and prospective stability of eNose derived inflammatory phenotypes in severe asthma

We have identified and followed-up exhaled molecular phenotypes of severe asthma, which were associated with changing inflammatory profile and oral steroid usage. This suggests that breath analysis might contribute to the management of severe asthma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EiQDrV

Experts say My Health Record is 10 years out of date and other countries have abandoned similar systems - ABC News

10129272-3x2-700x467.jpg

Experts say My Health Record is 10 years out of date and other countries have abandoned similar systems  ABC News

The My Health Record digital database is using an old technology designed to share data between providers and patients, not other providers, and still does not ...



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Good local tumor control but lethal hemorrhage after apatinib treatmen | OTT - Dove Medical Press

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Good local tumor control but lethal hemorrhage after apatinib treatmen | OTT  Dove Medical Press

Good local tumor control but lethal hemorrhage after apatinib treatment for intractable squamous carcinoma of the floor of the mouth: a case report Xiaopeng Zhu ...



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Experts say My Health Record is 10 years out of date and other countries have abandoned similar systems - ABC News

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Experts say My Health Record is 10 years out of date and other countries have abandoned similar systems  ABC News

The My Health Record digital database is using an old technology designed to share data between providers and patients, not other providers, and still does not ...



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Good local tumor control but lethal hemorrhage after apatinib treatmen | OTT - Dove Medical Press

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Good local tumor control but lethal hemorrhage after apatinib treatmen | OTT  Dove Medical Press

Good local tumor control but lethal hemorrhage after apatinib treatment for intractable squamous carcinoma of the floor of the mouth: a case report Xiaopeng Zhu ...



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4 Key Ingredients to Avoid in Cosmetics

You're reading 4 Key Ingredients to Avoid in Cosmetics, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. As you walk down a store's beauty aisle, it's easy to choose the most popular brands and products that line the shelves. After all, they are on sale and the labels claim to be organic or all natural. Despite these perks, what consumers fail to realize is that these labels can deceive consumers into believing their items are safe and toxin-free. The truth is the beauty market across the United States has lacked regulation compared to other areas around the world. While Europe has an official ban on well over 1,000 toxic ingredients, our nation has only banned 30 chemicals. This unset...

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What to Look For in Luxury Treatment

Individualized Treatment When you are looking for a luxury treatment center, it is extremely important that you find individualized treatment for your needs. No two addictions are the same; everyone has different experiences, traumas and life stories that lead to addiction. Detoxing and withdrawal symptoms can differ in severity, circumstances are different from client to client and needs are constantly changing. That's why it is important that you find a luxury treatment center that will take the time to develop a plan for your individual needs. Evidence-Based Treatment Upon entering luxury treatment, you will first need to undergo the detoxification process. This is often one of the most uncomfortable and most feared reasons for entering treatment for addiction. That is why we strive h...

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4 Key Ingredients to Avoid in Cosmetics

You're reading 4 Key Ingredients to Avoid in Cosmetics, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. As you walk down a store's beauty aisle, it's easy to choose the most popular brands and products that line the shelves. After all, they are on sale and the labels claim to be organic or all natural. Despite these perks, what consumers fail to realize is that these labels can deceive consumers into believing their items are safe and toxin-free. The truth is the beauty market across the United States has lacked regulation compared to other areas around the world. While Europe has an official ban on well over 1,000 toxic ingredients, our nation has only banned 30 chemicals. This unset...

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Interpace Diagnostics Group (NASDAQ:IDXG) Given a $3.00 Price Target at HC Wainwright - Fairfield Current

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Interpace Diagnostics Group (NASDAQ:IDXG) Given a $3.00 Price Target at HC Wainwright  Fairfield Current

Interpace Diagnostics Group (NASDAQ:IDXG) has been assigned a $3.00 price target by research analysts at HC Wainwright in a note issued to investors on ...



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Quick Take: Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study - 2 Minute Medicine

Thyroid_papillary_carcinoma_10.jpg

Quick Take: Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study  2 Minute Medicine

In the evaluation of thyroid nodules, fine needle aspirate (FNA) cytology can classify most thyroid nodules as benign or malignant; a minority of results,



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FDA Approves Genentech's Tecentriq in Combination With Avastin and Chemotherapy for the Initial Treatment of People With a Specific Type of Metastatic Lung Cancer - BioSpace

CT?id=bwnews&sty=20181206005992r1&sid=60

FDA Approves Genentech's Tecentriq in Combination With Avastin and Chemotherapy for the Initial Treatment of People With a Specific Type of Metastatic Lung Cancer  BioSpace

Approval based on survival benefit of Tecentriq, in combination with Avastin, paclitaxel and carboplatin (chemotherapy), in people with metastatic ...



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Evaluation of biochemical variables in patients with trigeminal neuralgia

The aim of this study was to evaluate the calcium, sodium, potassium, serum iron, vitamin B12, and albumin concentrations, and alkaline phosphatase (ALP) activity, in samples of serum from patients with primary trigeminal neuralgia (TN), and investigate the associations between them. Results from 73 patients who had been diagnosed with primary TN between December 2015 and 2017 were compared with those of 70 healthy subjects. Calcium (p=0.013), iron (p=0.004), and albumin (p=0.001) concentrations in the primary TN group were significantly lower than those in the control group, whereas the ALP activity was significantly higher in the TN group than in the control group (p=0.007). (Source: The British Journal of Oral and Maxillofacial Surgery)

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Qualitative study to identify issues affecting quality of life in adults with craniofacial anomalies

Our objective was to identify key issues that affect the quality of life (QoL) of adult patients with craniofacial anomalies. This was a qualitative prospective study using in-depth, semi-structured interviews. Ten patients who fulfilled the inclusion criteria were recruited during their attendance at the Adult Craniofacial Clinic at the Eastman Dental Hospital, University College London Hospitals NHS Foundation Trust. Interviews ceased when no new themes arose. A framework method of analysis was used to identify themes that related to QoL. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Interpace Diagnostics Group (NASDAQ:IDXG) Given a $3.00 Price Target at HC Wainwright - Fairfield Current

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Interpace Diagnostics Group (NASDAQ:IDXG) Given a $3.00 Price Target at HC Wainwright  Fairfield Current

Interpace Diagnostics Group (NASDAQ:IDXG) has been assigned a $3.00 price target by research analysts at HC Wainwright in a note issued to investors on ...



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FDA Approves Genentech's Tecentriq in Combination With Avastin and Chemotherapy for the Initial Treatment of People With a Specific Type of Metastatic Lung Cancer - BioSpace

CT?id=bwnews&sty=20181206005992r1&sid=60

FDA Approves Genentech's Tecentriq in Combination With Avastin and Chemotherapy for the Initial Treatment of People With a Specific Type of Metastatic Lung Cancer  BioSpace

Approval based on survival benefit of Tecentriq, in combination with Avastin, paclitaxel and carboplatin (chemotherapy), in people with metastatic ...



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Evaluation of biochemical variables in patients with trigeminal neuralgia

The aim of this study was to evaluate the calcium, sodium, potassium, serum iron, vitamin B12, and albumin concentrations, and alkaline phosphatase (ALP) activity, in samples of serum from patients with primary trigeminal neuralgia (TN), and investigate the associations between them. Results from 73 patients who had been diagnosed with primary TN between December 2015 and 2017 were compared with those of 70 healthy subjects. Calcium (p=0.013), iron (p=0.004), and albumin (p=0.001) concentrations in the primary TN group were significantly lower than those in the control group, whereas the ALP activity was significantly higher in the TN group than in the control group (p=0.007). (Source: The British Journal of Oral and Maxillofacial Surgery)

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Global Follicular Thyroid Cancer Drug Market Size – AstraZeneca PLC, Exelixis, Inc., GlaxoSmithKline plc - Forest Fire News

Follicular-Thyroid-Cancer-Drug-13976.jpg

Global Follicular Thyroid Cancer Drug Market Size – AstraZeneca PLC, Exelixis, Inc., GlaxoSmithKline plc  Forest Fire News

Market Intelligence Data has launched a report on the Follicular Thyroid Cancer Drug Market that predicts future market trends and current market trends.



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Quick Take: Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study - 2 Minute Medicine

Thyroid_papillary_carcinoma_10.jpg

Quick Take: Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study  2 Minute Medicine

In the evaluation of thyroid nodules, fine needle aspirate (FNA) cytology can classify most thyroid nodules as benign or malignant; a minority of results,



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Seldinger technique in repair of the parotid duct

We describe the Seldinger technique with a central venous catheter, which makes repair easier. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Qualitative study to identify issues affecting quality of life in adults with craniofacial anomalies

Our objective was to identify key issues that affect the quality of life (QoL) of adult patients with craniofacial anomalies. This was a qualitative prospective study using in-depth, semi-structured interviews. Ten patients who fulfilled the inclusion criteria were recruited during their attendance at the Adult Craniofacial Clinic at the Eastman Dental Hospital, University College London Hospitals NHS Foundation Trust. Interviews ceased when no new themes arose. A framework method of analysis was used to identify themes that related to QoL. (Source: The British Journal of Oral and Maxillofacial Surgery)

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ALLERGY ANTIHISTAMINE (Diphenhydramine Hcl) Tablet [EQUALINE (SuperValu)]

Updated Date: Dec 6, 2018 EST (Source: DailyMed Drug Label Updates)

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ALLERGY RELIEF (Cetirizine Hcl) Capsule [EQUATE (Wal-Mart Stores, Inc.)]

Updated Date: Dec 6, 2018 EST (Source: DailyMed Drug Label Updates)

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ALLERGY RELIEF (Cetirizine Hcl) Capsule [EQUATE (Wal-Mart Stores, Inc.)]

Updated Date: Dec 6, 2018 EST (Source: DailyMed Drug Label Updates)

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ALLERGY ANTIHISTAMINE (Diphenhydramine Hcl) Tablet [EQUALINE (SuperValu)]

Updated Date: Dec 6, 2018 EST (Source: DailyMed Drug Label Updates)

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ALLERGY RELIEF (Cetirizine Hcl) Capsule [Safeway, Inc.]

Updated Date: Dec 6, 2018 EST (Source: DailyMed Drug Label Updates)

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Πέμπτη 6 Δεκεμβρίου 2018

Nonstandard do-not-resuscitate orders

Purpose of review Tattoos and medallions are examples of nonstandard do-not-resuscitate (DNR) orders that some people use to convey end-of-life wishes. These DNR orders are neither universally accepted nor understood for reasons discussed within this manuscript. Recent findings Studies show both providers and patients confuse the meaning and implication of DNR orders. In the United States, out-of-hospital DNR orders are legislated at the state level. Most states standardized out-of-hospital DNR orders so caregivers can immediately recognize and accept the order and act on its behalf. These out-of-hospital orders are complicated by the need to be printed on paper that does not always accompany the individual. Oregon created an online system whereby individuals recorded their end-of-life wishes that medical personnel can access with an Internet connection. This system improved communication of end-of-life wishes in patients who selected comfort care only. Summary To improve conveyance of an individual's wishes for end-of-life care, the authors discuss nationwide adoption of Oregon's online registry where a person's account could comprehensively document end-of-life wishes, be universally available in all healthcare institutions, and be searchable by common patient identifiers. Facial recognition software could identify unconscious patients who present without identification. Correspondence to Gregory E. Holt, MD, PhD, University of Miami School of Medicine, Miami, FL 33136, USA. E-mail: gholt@miami.edu Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.

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Penguins extend point streak to five with win against Jets - NHL.com

Penguins extend point streak to five with win against Jets  NHL.com

Derek Grant and Zach Aston-Reese scored in the third period to help the Pittsburgh Penguins rally for a 4-3 win against the Winnipeg Jets at Bell MTS Place on ...



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Microtonal Variation in Sung Cantonese

Conclusion: Cantonese singers use microtonal contours to reflect rising contours of Cantonese linguistic tones.Phonetica (Source: Phonetica)

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A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell's photodynamic therapy (PDT)

Publication date: Available online 5 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Joanna Nackiewicz, Marta Kliber-Jasik, Magdalena SkoniecznaAbstractZn-based phthalocyanine acts as drug or photosensitizer in photodynamic therapy (PDT) for the treatment of cancer cells. The activated zinc octacarboxyphthalocyanine (ZnPcOC) reacts with oxygen, to generate reactive oxygen species for the damage of melanoma cancer cells, Me45. This in vitro study aimed at investigating the cytotoxic effects of different concentrations of ZnPcOC activated with a diode laser (λ = 685 nm) on Me45, and normal human fibroblast cells, NHDF. To perform this study 104 cells/ml were seeded in 96-well plates and allowed to attach overnight, after which cells were treated wi...

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Protective effect of polysaccharide from Sophora japonica L. flower buds against UVB radiation in a human keratinocyte cell line (HaCaT cells)

In conclusion, PS pretreatment protected HaCaT keratinocytes from UVB irradiation-induced skin injuries effectively, and the underlying mechanism may involve MAPK signaling pathway which contribute to apoptotic cell death. However, further studies especially whose using human systems are needed to determine efficacy of PS in vivo.Graphical Abstract (Source: Journal of Photochemistry and Photobiology B: Biology)

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Lost in dictation. A cognitive approach to oral poetry: Frames, scripts and ‘unnecessary’ words in the Jebli ayyu

Publication date: January 2019Source: Language & Communication, Volume 64Author(s): Sarali GintsburgAbstractRecent interest in oral poetic traditions has centred on the possibility of applying cognitive linguistic categories in order to shed light on the nature of poetic improvisation across a range of cultures and historical periods (Boas, 2016). Frames, or topics or scenes, can be seen to be associated with particular scripts, consisting at least partly of formulaic language, which facilitates the process of poetic creation in real time. This paper focuses on the ayyu, a short improvised oral poetic genre common among the Jbala people of northern Morocco. In the first section, I examine the habitual repertoire of two singers, and show how they indeed associate particular frames (love, pi...

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Kinesio Taping Application in Dysphonic Singers

Kinesio Taping (KT) application in speech therapy has been studied in a few works about dysphonia, facial nerve palsy, sialorrhea, atypical deglutition, postsurgical recovery after thyroidectomy and laryngectomy. The aim of this study was the evaluation of the possible role of KT in supporting speech therapy in singers complaining of dysphonia using singing voice handicap index (SVHI), fundamental frequency (F0), shimmer, jitter and harmonic to noise ratio (mean H/N). (Source: Journal of Voice)

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An Investigation of Reliability of the Sunderland Tracheosophageal Voice Perceptual Scale

Conclusions: This study demonstrates good rater reliability for the majority of parameters on the SToPS scale, supporting the use of this tool within the clinical realm. However, further research is required to ascertain if any methods of increasing inter rater reliability on those parameters which did not reach good reliability can be identified.Folia Phoniatr Logop 2019;71:16 –23 (Source: Folia Phoniatrica et Logopaedica)

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Differential responses to constraints on naming agency among indigenous peoples and immigrants in Canada

This article illuminates the social structures and relations that shape agency for members of two marginalized groups in Canada and examines how individuals respond differently to constraints on their power to name themselves and their children. Constraints on spelling, structure and choice of name are framed according to the particular positions of indigenous peoples and immigrants in relation to European settler society as either 'original inhabitants' or 'recent arrivals'. These historically unequal power relations are manifest in intertwined ideologies of language, identity and nation, evident in ethnographic interviews, media reports and online commentary. Differential responses include resistance, endurance and assimilation. (Source: Language and Communication)

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Economic Analysis of a Three-Arm RCT Exploring the Delivery of Intensive, Prophylactic Swallowing Therapy to Patients with Head and Neck Cancer During (Chemo)Radiotherapy

This study investigated the clinical and patient-attributable costs of delivering an intensive, prophylactic swallowing therapy protocol via a new telepractice application "SwallowIT" as compared to clinician-directed FTF therapy and independent patient self-directed therapy. Patients (n = 79) with oropharyngeal HNC receiving definitive (C)RT were randomised to receive therapy via a: clinician-directed (n = 26), patient-directed (n = 27), orSwallowIT-assisted (n = 26) model of care. Data pertaining to health service costs (service time, consumables, therapy resources), patient-attributable costs (travel and wages) and patient-reported health-related quality of life (QoL) (AQoL-6D) were collected.SwallowIT provided a cost-efficient model of care when compared to the clin...

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Temporal aspects of self-monitoring for speech errors

We report two four-word tongue twister experiments eliciting consonantal errors and their repairs, in word initial and medial positions, testing some predictions relating to temporal aspects of self-monitoring. Main findings: (1) After internal error detection interrupting the speaking process takes more time than speech initiation of the error form. This implies that "covert repairs" are rare. (2) Word onset-to-cutoff times are longer for medial than for initial errors. This implies that scanning internal word forms for errors takes time. (3) Cutoff-to-repair times of 0 ms are overrepresented. This shows that often repairs are available at interruption. (4) Cutoff-to-repair times are longer for medial than initial consonants. This shows that repairing takes more time for medial than...

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