Purpose of review There is an urge to improve care for patients with hip fracture. The present review will compare the efficacy of spinal versus general anesthesia for patients requiring hip fracture surgery. Recent findings The present review gives an overview with particular emphasis on literature published during the past 24 months. Summary So far, no clear evidence form randomized trials exists to identify the best anesthesia technique for hip fracture surgery. However, several large-scale pragmatic trials are ongoing and will provide future guidance. Correspondence to Prof. Mark Coburn, Department of Anaesthesiology, Medical Faculty RWTH Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany. Tel: +49 241 8088179; fax: +49 241 8082593; e-mail: mcoburn@ukaachen.de Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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Πέμπτη 13 Δεκεμβρίου 2018
Pulse pressure and perioperative stroke
Purpose of review Central pulse pressure (PP), a marker of vascular stiffness, is a novel indicator of risk for perioperative morbidity including ischemic stroke. Appreciation for the mechanism by which vascular stiffness leads to organ dysfunction along with understanding its clinical detection may lead to improved patient management. Recent findings Vascular stiffness is associated with increased mortality and neurologic, cardiac, and renal injury in nonsurgical and surgical patients. Left ventricular hypertrophy and diastolic dysfunction along with microcirculatory changes in the low vascular resistance, high blood flow, cerebral and renal vasculature are seen in patients with vascular stiffness. Pulse wave velocity and the augmentation index have higher sensitivity for detecting of vascular stiffness than peripheral PP as the hemodynamic consequences of vascular stiffness are secondary to alterations in the central vasculature. Vascular stiffness alters cerebral autoregulation, resulting in a high likelihood of having a lower limit of autoregulation more than 65 mmHg during surgery. Vascular stiffness may predispose to cerebral hypoperfusion, increasing vulnerability to ischemic stroke, postoperative delirium, and acute kidney injury. Summary Vascular stiffness leads to alterations in cerebral, cardiac, and renal hemodynamics increasing the risk of perioperative ischemic stroke and neurologic, cardiac, and renal dysfunction. Correspondence to Charles W. Hogue, MD, Professor and Chair, Department of Anesthesiology, Northwestern University Feinberg School of Medicine, 251 East Huron St, Feinberg Pavilion 5-704, Chicago, IL 60611, USA. Tel: +1 312 926 2949; e-mail: charles.hogue@nm.org Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GgtcBf
High-flow nasal cannula oxygen therapy in patients undergoing thoracic surgery: current evidence and practice
Purpose of review: Patients undergoing thoracic surgery are at high risk for pulmonary and extra pulmonary complications, and may develop impairment of gas exchange during surgery and in the postoperative period. This review focuses on the potential benefits of high-flow nasal cannula (HFNC) oxygen therapy in those patients. Recent findings: HFNC oxygen therapy can be used pre, intra and postoperatively. However, evidence for the use of HFNC oxygen therapy is still limited. Most trials investigated the effects of HFNC oxygen therapy in the postoperative period only, with promising beneficial effects. Preoperative HFNC oxygen therapy might be an alternative to conventional techniques, and allows continuous oxygenation during the apneic time of laryngoscopy. In certain patients, thoracic surgery might be performed in awake and nonintubated patients who are breathing spontaneously. Under these conditions, HFNC oxygen therapy might be considered for respiratory support by experienced anesthesiologists. In the postoperative period, HFNC oxygen therapy can prevent escalation of respiratory management and has the potential to reduce the length of hospital stay. Throughout the perioperative period, close monitoring of patients receiving HFNC oxygen therapy is key, and intubation criteria to avoid delayed intubation should be defined a priori to prevent harm. Summary: HFNC oxygen therapy is a promising tool in the perioperative care of thoracic surgical patients, when properly set, performed by experienced staff and closely monitored. Correspondence to Marcelo Gama de Abreu, MD, MSc, PhD, DESA, Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscher Strasse 74, 01307 Dresden, Germany. Tel: +49 351 458 4488; e-mail: mgabreu@uniklinikum-dresden.de Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GgtdoN
Enhanced recovery in thoracic surgery: can fuzzy logic bring clear results?
Pulse pressure and perioperative stroke
Purpose of review Central pulse pressure (PP), a marker of vascular stiffness, is a novel indicator of risk for perioperative morbidity including ischemic stroke. Appreciation for the mechanism by which vascular stiffness leads to organ dysfunction along with understanding its clinical detection may lead to improved patient management. Recent findings Vascular stiffness is associated with increased mortality and neurologic, cardiac, and renal injury in nonsurgical and surgical patients. Left ventricular hypertrophy and diastolic dysfunction along with microcirculatory changes in the low vascular resistance, high blood flow, cerebral and renal vasculature are seen in patients with vascular stiffness. Pulse wave velocity and the augmentation index have higher sensitivity for detecting of vascular stiffness than peripheral PP as the hemodynamic consequences of vascular stiffness are secondary to alterations in the central vasculature. Vascular stiffness alters cerebral autoregulation, resulting in a high likelihood of having a lower limit of autoregulation more than 65 mmHg during surgery. Vascular stiffness may predispose to cerebral hypoperfusion, increasing vulnerability to ischemic stroke, postoperative delirium, and acute kidney injury. Summary Vascular stiffness leads to alterations in cerebral, cardiac, and renal hemodynamics increasing the risk of perioperative ischemic stroke and neurologic, cardiac, and renal dysfunction. Correspondence to Charles W. Hogue, MD, Professor and Chair, Department of Anesthesiology, Northwestern University Feinberg School of Medicine, 251 East Huron St, Feinberg Pavilion 5-704, Chicago, IL 60611, USA. Tel: +1 312 926 2949; e-mail: charles.hogue@nm.org Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GgtcBf
General versus spinal anesthesia for the elderly hip fractured patient
Purpose of review There is an urge to improve care for patients with hip fracture. The present review will compare the efficacy of spinal versus general anesthesia for patients requiring hip fracture surgery. Recent findings The present review gives an overview with particular emphasis on literature published during the past 24 months. Summary So far, no clear evidence form randomized trials exists to identify the best anesthesia technique for hip fracture surgery. However, several large-scale pragmatic trials are ongoing and will provide future guidance. Correspondence to Prof. Mark Coburn, Department of Anaesthesiology, Medical Faculty RWTH Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany. Tel: +49 241 8088179; fax: +49 241 8082593; e-mail: mcoburn@ukaachen.de Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rzhWpt
High-flow nasal cannula oxygen therapy in patients undergoing thoracic surgery: current evidence and practice
Purpose of review: Patients undergoing thoracic surgery are at high risk for pulmonary and extra pulmonary complications, and may develop impairment of gas exchange during surgery and in the postoperative period. This review focuses on the potential benefits of high-flow nasal cannula (HFNC) oxygen therapy in those patients. Recent findings: HFNC oxygen therapy can be used pre, intra and postoperatively. However, evidence for the use of HFNC oxygen therapy is still limited. Most trials investigated the effects of HFNC oxygen therapy in the postoperative period only, with promising beneficial effects. Preoperative HFNC oxygen therapy might be an alternative to conventional techniques, and allows continuous oxygenation during the apneic time of laryngoscopy. In certain patients, thoracic surgery might be performed in awake and nonintubated patients who are breathing spontaneously. Under these conditions, HFNC oxygen therapy might be considered for respiratory support by experienced anesthesiologists. In the postoperative period, HFNC oxygen therapy can prevent escalation of respiratory management and has the potential to reduce the length of hospital stay. Throughout the perioperative period, close monitoring of patients receiving HFNC oxygen therapy is key, and intubation criteria to avoid delayed intubation should be defined a priori to prevent harm. Summary: HFNC oxygen therapy is a promising tool in the perioperative care of thoracic surgical patients, when properly set, performed by experienced staff and closely monitored. Correspondence to Marcelo Gama de Abreu, MD, MSc, PhD, DESA, Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscher Strasse 74, 01307 Dresden, Germany. Tel: +49 351 458 4488; e-mail: mgabreu@uniklinikum-dresden.de Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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Enhanced recovery in thoracic surgery: can fuzzy logic bring clear results?
The Development of a Self-Efficacy Measurement Tool For Counseling in Speech-Language Pathology.
Conclusion: The adapted Counselor Activity Self-Efficacy Scales for speech-language pathologists is psychometrically sound; factor analysis, reliability, and validity were in line with reported values for the original survey tool. Potential uses for the survey tool within the field of speech-language pathology are discussed, along with implications for graduate education and clinical supervision related to counseling skills. PMID: 30535061 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
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Application of the Communication Complexity Scale in Peer and Adult Assessment Contexts for Preschoolers With Autism Spectrum Disorders.
Conclusions: Results showed that the CCS was sensitive to change over time but did not discriminate changes in communication complexity associated with maturation versus treatment. It did show some differences based on interactions with peer versus adult partners. Outcomes provide preliminary support for using this scale to measure communication changes in different contexts. Supplemental Material: https://ift.tt/2SzXdNB. PMID: 30521663 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
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Application of the Communication Complexity Scale in Peer and Adult Assessment Contexts for Preschoolers With Autism Spectrum Disorders.
Conclusions: Results showed that the CCS was sensitive to change over time but did not discriminate changes in communication complexity associated with maturation versus treatment. It did show some differences based on interactions with peer versus adult partners. Outcomes provide preliminary support for using this scale to measure communication changes in different contexts. Supplemental Material: https://ift.tt/2SzXdNB. PMID: 30521663 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
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Pulse pressure and perioperative stroke
Purpose of review Central pulse pressure (PP), a marker of vascular stiffness, is a novel indicator of risk for perioperative morbidity including ischemic stroke. Appreciation for the mechanism by which vascular stiffness leads to organ dysfunction along with understanding its clinical detection may lead to improved patient management. Recent findings Vascular stiffness is associated with increased mortality and neurologic, cardiac, and renal injury in nonsurgical and surgical patients. Left ventricular hypertrophy and diastolic dysfunction along with microcirculatory changes in the low vascular resistance, high blood flow, cerebral and renal vasculature are seen in patients with vascular stiffness. Pulse wave velocity and the augmentation index have higher sensitivity for detecting of vascular stiffness than peripheral PP as the hemodynamic consequences of vascular stiffness are secondary to alterations in the central vasculature. Vascular stiffness alters cerebral autoregulation, resulting in a high likelihood of having a lower limit of autoregulation more than 65 mmHg during surgery. Vascular stiffness may predispose to cerebral hypoperfusion, increasing vulnerability to ischemic stroke, postoperative delirium, and acute kidney injury. Summary Vascular stiffness leads to alterations in cerebral, cardiac, and renal hemodynamics increasing the risk of perioperative ischemic stroke and neurologic, cardiac, and renal dysfunction. Correspondence to Charles W. Hogue, MD, Professor and Chair, Department of Anesthesiology, Northwestern University Feinberg School of Medicine, 251 East Huron St, Feinberg Pavilion 5-704, Chicago, IL 60611, USA. Tel: +1 312 926 2949; e-mail: charles.hogue@nm.org Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GgtcBf
General versus spinal anesthesia for the elderly hip fractured patient
Purpose of review There is an urge to improve care for patients with hip fracture. The present review will compare the efficacy of spinal versus general anesthesia for patients requiring hip fracture surgery. Recent findings The present review gives an overview with particular emphasis on literature published during the past 24 months. Summary So far, no clear evidence form randomized trials exists to identify the best anesthesia technique for hip fracture surgery. However, several large-scale pragmatic trials are ongoing and will provide future guidance. Correspondence to Prof. Mark Coburn, Department of Anaesthesiology, Medical Faculty RWTH Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany. Tel: +49 241 8088179; fax: +49 241 8082593; e-mail: mcoburn@ukaachen.de Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rzhWpt
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rzhWpt
Enhanced recovery in thoracic surgery: can fuzzy logic bring clear results?
The Development of a Self-Efficacy Measurement Tool For Counseling in Speech-Language Pathology.
Conclusion: The adapted Counselor Activity Self-Efficacy Scales for speech-language pathologists is psychometrically sound; factor analysis, reliability, and validity were in line with reported values for the original survey tool. Potential uses for the survey tool within the field of speech-language pathology are discussed, along with implications for graduate education and clinical supervision related to counseling skills. PMID: 30535061 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EmCclZ
General versus spinal anesthesia for the elderly hip fractured patient
Purpose of review There is an urge to improve care for patients with hip fracture. The present review will compare the efficacy of spinal versus general anesthesia for patients requiring hip fracture surgery. Recent findings The present review gives an overview with particular emphasis on literature published during the past 24 months. Summary So far, no clear evidence form randomized trials exists to identify the best anesthesia technique for hip fracture surgery. However, several large-scale pragmatic trials are ongoing and will provide future guidance. Correspondence to Prof. Mark Coburn, Department of Anaesthesiology, Medical Faculty RWTH Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany. Tel: +49 241 8088179; fax: +49 241 8082593; e-mail: mcoburn@ukaachen.de Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rzhWpt
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rzhWpt
High-flow nasal cannula oxygen therapy in patients undergoing thoracic surgery: current evidence and practice
Purpose of review: Patients undergoing thoracic surgery are at high risk for pulmonary and extra pulmonary complications, and may develop impairment of gas exchange during surgery and in the postoperative period. This review focuses on the potential benefits of high-flow nasal cannula (HFNC) oxygen therapy in those patients. Recent findings: HFNC oxygen therapy can be used pre, intra and postoperatively. However, evidence for the use of HFNC oxygen therapy is still limited. Most trials investigated the effects of HFNC oxygen therapy in the postoperative period only, with promising beneficial effects. Preoperative HFNC oxygen therapy might be an alternative to conventional techniques, and allows continuous oxygenation during the apneic time of laryngoscopy. In certain patients, thoracic surgery might be performed in awake and nonintubated patients who are breathing spontaneously. Under these conditions, HFNC oxygen therapy might be considered for respiratory support by experienced anesthesiologists. In the postoperative period, HFNC oxygen therapy can prevent escalation of respiratory management and has the potential to reduce the length of hospital stay. Throughout the perioperative period, close monitoring of patients receiving HFNC oxygen therapy is key, and intubation criteria to avoid delayed intubation should be defined a priori to prevent harm. Summary: HFNC oxygen therapy is a promising tool in the perioperative care of thoracic surgical patients, when properly set, performed by experienced staff and closely monitored. Correspondence to Marcelo Gama de Abreu, MD, MSc, PhD, DESA, Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscher Strasse 74, 01307 Dresden, Germany. Tel: +49 351 458 4488; e-mail: mgabreu@uniklinikum-dresden.de Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GgtdoN
Enhanced recovery in thoracic surgery: can fuzzy logic bring clear results?
Pulse pressure and perioperative stroke
Purpose of review Central pulse pressure (PP), a marker of vascular stiffness, is a novel indicator of risk for perioperative morbidity including ischemic stroke. Appreciation for the mechanism by which vascular stiffness leads to organ dysfunction along with understanding its clinical detection may lead to improved patient management. Recent findings Vascular stiffness is associated with increased mortality and neurologic, cardiac, and renal injury in nonsurgical and surgical patients. Left ventricular hypertrophy and diastolic dysfunction along with microcirculatory changes in the low vascular resistance, high blood flow, cerebral and renal vasculature are seen in patients with vascular stiffness. Pulse wave velocity and the augmentation index have higher sensitivity for detecting of vascular stiffness than peripheral PP as the hemodynamic consequences of vascular stiffness are secondary to alterations in the central vasculature. Vascular stiffness alters cerebral autoregulation, resulting in a high likelihood of having a lower limit of autoregulation more than 65 mmHg during surgery. Vascular stiffness may predispose to cerebral hypoperfusion, increasing vulnerability to ischemic stroke, postoperative delirium, and acute kidney injury. Summary Vascular stiffness leads to alterations in cerebral, cardiac, and renal hemodynamics increasing the risk of perioperative ischemic stroke and neurologic, cardiac, and renal dysfunction. Correspondence to Charles W. Hogue, MD, Professor and Chair, Department of Anesthesiology, Northwestern University Feinberg School of Medicine, 251 East Huron St, Feinberg Pavilion 5-704, Chicago, IL 60611, USA. Tel: +1 312 926 2949; e-mail: charles.hogue@nm.org Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.
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Data‐driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later
Abstract
Background
Research based on cluster analyses led to the identification of particular phenotypes confirming phenotypic heterogeneity of asthma. The long‐term clinical course of asthma phenotypes defined by clustering analysis remains unknown, although it is a key aspect to underpin their clinical relevance. We aimed to estimate risk of poor asthma events between asthma clusters identified 20 years earlier.
Methods
The study relied on two cohorts of adults with asthma with 20‐year follow‐up, ECRHS (European Community Respiratory Health Survey) and EGEA (Epidemiological study on Genetics and Environment of Asthma). Regression models were used to compare asthma characteristics (current asthma, asthma exacerbations, asthma control, quality of life and FEV1) at follow‐up and the course of FEV1 between seven cluster‐based asthma phenotypes identified 20 years earlier.
Results
The analysis included 1325 adults with ever asthma. For each asthma characteristic assessed at follow‐up, the risk for adverse outcomes differed significantly between the seven asthma clusters identified at baseline. As compared with the mildest asthma phenotype, ORs (95%CI) for asthma exacerbations varied from 0.9 (0.4 to 2.0) to 4.0 (2.0 to 7.8) and the regression estimates (95%CI) for FEV1% predicted varied from 0.6 (‐3.5 to 4.6) to ‐9.9 (‐14.2 to ‐5.5) between clusters. Change of FEV1 over time did not differ significantly across clusters.
Conclusion
Our findings show that the long‐term risk for poor asthma outcomes differed between comprehensive adult asthma phenotypes identified 20‐years earlier, and suggest a strong tracking of asthma activity and impaired lung function over time.
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Is abdominal x-ray (AXR) or computed tomography (CT) of the abdomen the most appropriate imaging modality for the detection of illegal substances concealed, taking into consideration the sensitivity, specificity and radiation dose?
Publication date: Available online 13 December 2018
Source: Journal of Forensic Radiology and Imaging
Author(s): Kiki Lan, Edel Doyle
Abstract
Body packing is the internal concealment of illicit substances within the alimentary tract with the intention of smuggling them across borders and evading law enforcement. Medical imaging plays an important role in the management of suspected body packers through the identification of drug packets, as well as recognising medical complications. This literature review aims to determine whether abdominal radiography (AXR) or computed tomography [CT] is the most appropriate imaging modality for the detection of illegal substances in suspected body packers, taking into consideration the sensitivity, specificity and radiation dose. In addition, whether CT could completely replace the use of radiography given the radiation dose of CT can be decreased to levels that can be comparable to x-ray. AXR is a widely available and relatively low-dose modality commonly performed as the first line of imaging for suspected body packers but is very unreliable due to its highly variable sensitivity of 40–90% and high false positive and false negative rates. CT has a reported sensitivity and specificity of close to 100% but is not used as an initial imaging modality due to its higher radiation dose. CT is not only superior in sensitivity and specificity, but radiologists are also able to accurately identify the number of packets and their locations within the body while delivering radiation doses similar or even below the average dose of an AXR. The use of a low-dose CT protocol with reduced mAs is now preferred as the initial screening tool for suspected body packers over AXR.
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Very affordable post mortem CT angiography kit: feasibility study using immersion pump and 3D printed parts
Publication date: Available online 12 December 2018
Source: Journal of Forensic Radiology and Imaging
Author(s): Wolf Schweitzer, Markus Enders, Michael Thali
Abstract
The high cost of commercial components and parts for post-mortem computed tomography angiography (PMCTA) has resulted in the development of a very low cost PMCTA-kit. It contains ubiquitous parts from hardware stores, and rapid prototyping derived models for 3D-printing. Design specifications have been tested and improved after finite-element modeling. A case study performed in using the final PMCTA kit parts for a PMCTA shows perfect vascular contrast without relevant leaks.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GhShvB
Is abdominal x-ray (AXR) or computed tomography (CT) of the abdomen the most appropriate imaging modality for the detection of illegal substances concealed, taking into consideration the sensitivity, specificity and radiation dose?
Publication date: Available online 13 December 2018
Source: Journal of Forensic Radiology and Imaging
Author(s): Kiki Lan, Edel Doyle
Abstract
Body packing is the internal concealment of illicit substances within the alimentary tract with the intention of smuggling them across borders and evading law enforcement. Medical imaging plays an important role in the management of suspected body packers through the identification of drug packets, as well as recognising medical complications. This literature review aims to determine whether abdominal radiography (AXR) or computed tomography [CT] is the most appropriate imaging modality for the detection of illegal substances in suspected body packers, taking into consideration the sensitivity, specificity and radiation dose. In addition, whether CT could completely replace the use of radiography given the radiation dose of CT can be decreased to levels that can be comparable to x-ray. AXR is a widely available and relatively low-dose modality commonly performed as the first line of imaging for suspected body packers but is very unreliable due to its highly variable sensitivity of 40–90% and high false positive and false negative rates. CT has a reported sensitivity and specificity of close to 100% but is not used as an initial imaging modality due to its higher radiation dose. CT is not only superior in sensitivity and specificity, but radiologists are also able to accurately identify the number of packets and their locations within the body while delivering radiation doses similar or even below the average dose of an AXR. The use of a low-dose CT protocol with reduced mAs is now preferred as the initial screening tool for suspected body packers over AXR.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ryAgij
Very affordable post mortem CT angiography kit: feasibility study using immersion pump and 3D printed parts
Publication date: Available online 12 December 2018
Source: Journal of Forensic Radiology and Imaging
Author(s): Wolf Schweitzer, Markus Enders, Michael Thali
Abstract
The high cost of commercial components and parts for post-mortem computed tomography angiography (PMCTA) has resulted in the development of a very low cost PMCTA-kit. It contains ubiquitous parts from hardware stores, and rapid prototyping derived models for 3D-printing. Design specifications have been tested and improved after finite-element modeling. A case study performed in using the final PMCTA kit parts for a PMCTA shows perfect vascular contrast without relevant leaks.
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U.S. Diplomats With Mysterious Illness in Cuba Had Inner-Ear Damage, Doctors Say
A report by the first doctors to examine Americans who suffered mystifying symptoms after hearing a high-pitched sound at the embassy in Cuba confirms that their condition is real. (Source: NYT Health)
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Patient's Elevated Airway Pressure Puzzles Providers
An ALS crew is dispatched to the scene of a patient reported to have altered mental status and difficulty breathing. Upon arrival, you and your partner find a middle-age woman lying on the floor in the care of first responders with visibly shallow respirations. According to the patient's family, she was in her normal state of health and sitting in her recliner when she suddenly raised her hands into the air and began grabbing at both sides of her head. She then fell forward and was assisted to the ground by family. Family members describe grunting respirations that began shortly thereafter and no change in her mental status from the time of the 9-1-1 call until the arrival of the paramedics. She reportedly has no medical problems, takes no medications and hasn't recently suffered any i...
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U.S. Diplomats With Mysterious Illness in Cuba Had Inner-Ear Damage, Doctors Say
A report by the first doctors to examine Americans who suffered mystifying symptoms after hearing a high-pitched sound at the embassy in Cuba confirms that their condition is real. (Source: NYT Health)
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Parent-Implemented Communication Treatment for Infants and Toddlers With Hearing Loss: A Randomized Pilot Trial.
Conclusions: This study provides modest preliminary support for the short-term effects of a parent-implemented communication treatment for children with hearing loss. Parents learned communication support strategies that subsequently impacted child prelinguistic skills. Although these results appear promising, the sample size is very small. Future research should include a larger clinical trial and child-level predictors of response to treatment. PMID: 30535174 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
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The Development of a Self-Efficacy Measurement Tool For Counseling in Speech-Language Pathology.
Conclusion: The adapted Counselor Activity Self-Efficacy Scales for speech-language pathologists is psychometrically sound; factor analysis, reliability, and validity were in line with reported values for the original survey tool. Potential uses for the survey tool within the field of speech-language pathology are discussed, along with implications for graduate education and clinical supervision related to counseling skills. PMID: 30535061 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
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Peri-operative endothelial dysfunction in patients undergoing minor abdominal surgery: An observational study
BACKGROUND Myocardial injury after noncardiac surgery is common and associated with major adverse cardiac events. Surgery induces acute endothelial dysfunction, which might be central in the pathophysiology of myocardial injury; however, the relationship between surgical stress and endothelial function remains incompletely understood. OBJECTIVES This study aimed to assess the acute peri-operative changes in endothelial function after minor elective abdominal surgery. DESIGN A prospective, observational, single-centre study. SETTING A university hospital from February 2016 to January 2017. PATIENTS Sixty patients undergoing elective minor abdominal surgery. MAIN OUTCOME MEASURES The change in endothelial function, expressed as the reactive hyperaemia index (RHI), was assessed by non-invasive digital pulse tonometry. RHI, biomarkers of nitric oxide bioavailability and oxidative stress were assessed prior to and 4 h after surgery. RESULTS RHI decreased significantly from 1.93 [95% confidence interval (95% CI 1.78 to 2.09)] before surgery to 1.76 (95% CI 1.64 to 1.90), P = 0.03, after surgery. The nitric oxide production, L-arginine/asymmetric dimethylarginine, decreased significantly from a ratio of 213.39 (95% CI 188.76 to 241.2) to a ratio of 193.3 (95% CI 171.82 to 217.54), P = 0.03. Plasma biopterins increased significantly after surgery, while the ratio between tetrahydrobiopterin and dihydrobiopterin was unchanged. Total ascorbic acid decreased significantly after surgery (P
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Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases.
Authors: Vishwakarma SK, Lakkireddy C, Bardia A, Paspala SAB, Tripura C, Habeeb MA, Khan AA Abstract End stage liver diseases (ESLD) represent a major, neglected global public health crisis which requires an urgent action towards finding a proper cure. Orthotropic liver transplantation has been the only definitive treatment modality for ESLD. However, shortage of donor organs, timely unavailability, post-surgery related complications and financial burden on the patients limits the number of patients receiving the transplants. Since last two decades cell-based therapies have revolutionized the field of organ/tissue regeneration. However providing an alternative organ source to address the donor liver shortage still poses potential challenges. The developments made in this direction ...
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Parent-Implemented Communication Treatment for Infants and Toddlers With Hearing Loss: A Randomized Pilot Trial.
Conclusions: This study provides modest preliminary support for the short-term effects of a parent-implemented communication treatment for children with hearing loss. Parents learned communication support strategies that subsequently impacted child prelinguistic skills. Although these results appear promising, the sample size is very small. Future research should include a larger clinical trial and child-level predictors of response to treatment. PMID: 30535174 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
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Peri-operative endothelial dysfunction in patients undergoing minor abdominal surgery: An observational study
BACKGROUND Myocardial injury after noncardiac surgery is common and associated with major adverse cardiac events. Surgery induces acute endothelial dysfunction, which might be central in the pathophysiology of myocardial injury; however, the relationship between surgical stress and endothelial function remains incompletely understood. OBJECTIVES This study aimed to assess the acute peri-operative changes in endothelial function after minor elective abdominal surgery. DESIGN A prospective, observational, single-centre study. SETTING A university hospital from February 2016 to January 2017. PATIENTS Sixty patients undergoing elective minor abdominal surgery. MAIN OUTCOME MEASURES The change in endothelial function, expressed as the reactive hyperaemia index (RHI), was assessed by non-invasive digital pulse tonometry. RHI, biomarkers of nitric oxide bioavailability and oxidative stress were assessed prior to and 4 h after surgery. RESULTS RHI decreased significantly from 1.93 [95% confidence interval (95% CI 1.78 to 2.09)] before surgery to 1.76 (95% CI 1.64 to 1.90), P = 0.03, after surgery. The nitric oxide production, L-arginine/asymmetric dimethylarginine, decreased significantly from a ratio of 213.39 (95% CI 188.76 to 241.2) to a ratio of 193.3 (95% CI 171.82 to 217.54), P = 0.03. Plasma biopterins increased significantly after surgery, while the ratio between tetrahydrobiopterin and dihydrobiopterin was unchanged. Total ascorbic acid decreased significantly after surgery (P
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Interpace Diagnostics Group (NASDAQ:IDXG) PT Set at $4.00 by Maxim Group - Fairfield Current
Interpace Diagnostics Group (NASDAQ:IDXG) has been given a $4.00 target price by equities researchers at Maxim Group in a research report issued to clients ...
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Anaplastic Thyroid Cancer Market Preregistration Drugs by Key Players 2018 - The Comic Journal
Global Anaplastic Thyroid Cancer Market 2018 Research Report signifies an extensive analysis of global Anaplastic Thyroid Cancer industry by delivering an ...
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Growing Adoption of Mobile Gamma Cameras in Cancer Therapeutics to Facilitate Growth - Press Release - Digital Journal
Growing Adoption of Mobile Gamma Cameras in Cancer Therapeutics to Facilitate Growth - Press Release Digital Journal
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This press release was orginally distributed by SBWire. Albany, NY -- (SBWIRE) -- 12/12/2018 -- Mobile gamma cameras find amplified usability in organ ...
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Interpace Diagnostics Group (NASDAQ:IDXG) PT Set at $4.00 by Maxim Group - Fairfield Current
Interpace Diagnostics Group (NASDAQ:IDXG) has been given a $4.00 target price by equities researchers at Maxim Group in a research report issued to clients ...
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Anaplastic Thyroid Cancer Market Preregistration Drugs by Key Players 2018 - The Comic Journal
Global Anaplastic Thyroid Cancer Market 2018 Research Report signifies an extensive analysis of global Anaplastic Thyroid Cancer industry by delivering an ...
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Growing Adoption of Mobile Gamma Cameras in Cancer Therapeutics to Facilitate Growth - Press Release - Digital Journal
Growing Adoption of Mobile Gamma Cameras in Cancer Therapeutics to Facilitate Growth - Press Release Digital Journal
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This press release was orginally distributed by SBWire. Albany, NY -- (SBWIRE) -- 12/12/2018 -- Mobile gamma cameras find amplified usability in organ ...
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Head and Neck Cancer Market Analysis of Sales, Revenue, Share and Growth Rate to 2026 - Coherent Wire
Head and Neck Cancer Market Analysis of Sales, Revenue, Share and Growth Rate to 2026 Coherent Wire
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The report presents an introductory as well as detailed information about the Triptorelin Market through a well-organized layout divided into easy to understand ...
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Saint Barnabas is First to Offer Halcyon System for Image-Guided Cancer Treatments - TAPinto.net
Saint Barnabas is First to Offer Halcyon System for Image-Guided Cancer Treatments TAPinto.net
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LIVINGSTON, NJ — Saint Barnabas Medical Center's (SBMC) Department of Radiation Oncology is the first in New Jersey to offer the Halcyon system for ...
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Head and Neck Cancer Market Analysis of Sales, Revenue, Share and Growth Rate to 2026 - Coherent Wire
Head and Neck Cancer Market Analysis of Sales, Revenue, Share and Growth Rate to 2026 Coherent Wire
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The report presents an introductory as well as detailed information about the Triptorelin Market through a well-organized layout divided into easy to understand ...
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Saint Barnabas is First to Offer Halcyon System for Image-Guided Cancer Treatments - TAPinto.net
Saint Barnabas is First to Offer Halcyon System for Image-Guided Cancer Treatments TAPinto.net
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LIVINGSTON, NJ — Saint Barnabas Medical Center's (SBMC) Department of Radiation Oncology is the first in New Jersey to offer the Halcyon system for ...
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Volumetric 18F‐FDG‐PET parameters as predictors of locoregional failure in low‐risk HPV‐related oropharyngeal cancer after definitive chemoradiation therapy
Abstract
Background
We sought to investigate the prognostic value of volumetric positron emission tomography (PET) parameters in patients with human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC) and a ≤10 pack‐year smoking history treated with chemoradiation.
Methods
A total of 142 patients were included. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, involved regional lymph nodes, and total lesion were calculated. Cox proportional hazard modeling was used to evaluate associations of clinical and PET parameters with locoregional failure‐free survival (LRFFS), distant metastasis‐free survival (DMFS), and overall survival (OS).
Results
On univariate analysis, volumetric PET parameters were significantly associated with all endpoints, and 8th edition American Joint Committee on Cancer/Union Internationale Contre le Cancer staging was significantly associated with DMFS and OS. On multivariate analysis, total lesion TLG was significantly associated with LRFFS, while staging was most significantly prognostic for DMFS and OS.
Conclusion
Volumetric PET parameters are uniquely prognostic of LRFFS in low‐risk HPV‐related OPSCC and may be useful for directing de‐intensification strategies.
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Volumetric 18F‐FDG‐PET parameters as predictors of locoregional failure in low‐risk HPV‐related oropharyngeal cancer after definitive chemoradiation therapy
Abstract
Background
We sought to investigate the prognostic value of volumetric positron emission tomography (PET) parameters in patients with human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC) and a ≤10 pack‐year smoking history treated with chemoradiation.
Methods
A total of 142 patients were included. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, involved regional lymph nodes, and total lesion were calculated. Cox proportional hazard modeling was used to evaluate associations of clinical and PET parameters with locoregional failure‐free survival (LRFFS), distant metastasis‐free survival (DMFS), and overall survival (OS).
Results
On univariate analysis, volumetric PET parameters were significantly associated with all endpoints, and 8th edition American Joint Committee on Cancer/Union Internationale Contre le Cancer staging was significantly associated with DMFS and OS. On multivariate analysis, total lesion TLG was significantly associated with LRFFS, while staging was most significantly prognostic for DMFS and OS.
Conclusion
Volumetric PET parameters are uniquely prognostic of LRFFS in low‐risk HPV‐related OPSCC and may be useful for directing de‐intensification strategies.
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The spectrum of cloacal malformations: how to differentiate each entity prenatally with fetal MRI
Abstract
The term cloacal malformation is commonly used to describe the classic cloacal malformation where there is a single common urogenital and intestinal channel located at the expected site of the urethra. There is, however, a spectrum of cloacal abnormalities that differ from this classic type and are less well discussed in the radiologic and surgical literature. The aim of this pictorial essay is to familiarize radiologists with the anatomy, appropriate terminology and key prenatal imaging findings that differentiate the six entities that constitute the spectrum of cloacal abnormalities.
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The spectrum of cloacal malformations: how to differentiate each entity prenatally with fetal MRI
Abstract
The term cloacal malformation is commonly used to describe the classic cloacal malformation where there is a single common urogenital and intestinal channel located at the expected site of the urethra. There is, however, a spectrum of cloacal abnormalities that differ from this classic type and are less well discussed in the radiologic and surgical literature. The aim of this pictorial essay is to familiarize radiologists with the anatomy, appropriate terminology and key prenatal imaging findings that differentiate the six entities that constitute the spectrum of cloacal abnormalities.
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Excess Body Weight Responsible for 4% of Cancers Worldwide - Technology Networks
Policies, economic systems, and marketing practices that promote the consumption of energy-dense, nutrient-poor food, changing behavioral patterns that ...
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Size Matters: Height May Heighten Risk Factor for Certain Cancers, Study Finds - Lymphoma News Today
Size Matters: Height May Heighten Risk Factor for Certain Cancers, Study Finds Lymphoma News Today
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Taller people have a higher risk of developing some types of cancer — including lymphoma — because they have a larger number of cells, according to a ...
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Rare anatomic variation of the hepatic arterial blood supply: case report and literature review
Abstract
Purpose
Our aim is to present a rare case of anatomic variation of the arterial blood supply to the liver because preoperative knowledge of hepatic vascular variations is mandatory in hepatic surgery and liver transplantation.
Methods
We present a case of unusual arterial blood supply to the liver, a right hepatic artery coming from the splenic artery, associated to a classical common hepatic artery and a left hepatic artery from the left gastric artery. Preoperative diagnosis was made using CT-scan and 3D reconstruction.
Results
The right hepatic artery was found behind the portal vein and its diameter showed its importance in the vascularisation of the liver. To our knowledge this type of variation has only twice been described before. The accuracy of the 3D reconstruction allowed us to adopt the best surgical strategy to avoid lesions of the two accessory arteries which proved important sources of blood supply.
Conclusions
Precise preoperative evaluation of liver blood supply has great importance on surgical, transplantation strategy and outcome and rare anatomic variations have to be known to avoid lesions of potentially important arteries. New techniques of 3D reconstruction can ease the preoperative recognition of such difficult anatomic variations.
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FDA Approval To Larotrectinib Is The First Treatment To Receive A Tumor-Agnostic Indication - Food, Drugs, Healthcare, Life Sciences - Worldwide - Mondaq News Alerts
FDA Approval To Larotrectinib Is The First Treatment To Receive A Tumor-Agnostic Indication - Food, Drugs, Healthcare, Life Sciences - Worldwide Mondaq News Alerts
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Larotrectinib, is a CNS active TRK inhibitor designed to inhibit these proteins. Worldwide Food, Drugs, Healthcare, Life Sciences Singh & Associates 13 Dec ...
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Follicular Thyroid Cancer Drug Market Major Players Competitive Landscape – AstraZeneca PLC, Exelixis, Inc., GlaxoSmithKline plc - Chesco DOES
The Global Market for Follicular Thyroid Cancer Drug to 2023 offers detailed coverage of Follicular Thyroid Cancer Drug industry and presents main market ...
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Size Matters: Height May Heighten Risk Factor for Certain Cancers, Study Finds - Lymphoma News Today
Size Matters: Height May Heighten Risk Factor for Certain Cancers, Study Finds Lymphoma News Today
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Taller people have a higher risk of developing some types of cancer — including lymphoma — because they have a larger number of cells, according to a ...
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Excess Body Weight Responsible for 4% of Cancers Worldwide - Technology Networks
Policies, economic systems, and marketing practices that promote the consumption of energy-dense, nutrient-poor food, changing behavioral patterns that ...
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FDA Approval To Larotrectinib Is The First Treatment To Receive A Tumor-Agnostic Indication - Food, Drugs, Healthcare, Life Sciences - Worldwide - Mondaq News Alerts
FDA Approval To Larotrectinib Is The First Treatment To Receive A Tumor-Agnostic Indication - Food, Drugs, Healthcare, Life Sciences - Worldwide Mondaq News Alerts
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Larotrectinib, is a CNS active TRK inhibitor designed to inhibit these proteins. Worldwide Food, Drugs, Healthcare, Life Sciences Singh & Associates 13 Dec ...
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Rare anatomic variation of the hepatic arterial blood supply: case report and literature review
Abstract
Purpose
Our aim is to present a rare case of anatomic variation of the arterial blood supply to the liver because preoperative knowledge of hepatic vascular variations is mandatory in hepatic surgery and liver transplantation.
Methods
We present a case of unusual arterial blood supply to the liver, a right hepatic artery coming from the splenic artery, associated to a classical common hepatic artery and a left hepatic artery from the left gastric artery. Preoperative diagnosis was made using CT-scan and 3D reconstruction.
Results
The right hepatic artery was found behind the portal vein and its diameter showed its importance in the vascularisation of the liver. To our knowledge this type of variation has only twice been described before. The accuracy of the 3D reconstruction allowed us to adopt the best surgical strategy to avoid lesions of the two accessory arteries which proved important sources of blood supply.
Conclusions
Precise preoperative evaluation of liver blood supply has great importance on surgical, transplantation strategy and outcome and rare anatomic variations have to be known to avoid lesions of potentially important arteries. New techniques of 3D reconstruction can ease the preoperative recognition of such difficult anatomic variations.
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Follicular Thyroid Cancer Drug Market Major Players Competitive Landscape – AstraZeneca PLC, Exelixis, Inc., GlaxoSmithKline plc - Chesco DOES
The Global Market for Follicular Thyroid Cancer Drug to 2023 offers detailed coverage of Follicular Thyroid Cancer Drug industry and presents main market ...
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Motor endplate‐expressing cartilage‐muscle implants for reconstruction of a denervated hemilarynx
Objective
Tissue engineering of the larynx requires a complex, multiple tissue layer design. Additionally, spontaneous reinnervation of the larynx after recurrent laryngeal nerve (RLN) injury is often disorganized, resulting in subpar function. This study investigates use of tissue‐engineered cartilage and motor endplate‐expressing (MEE) tissue‐engineered skeletal muscle implants for laryngeal reconstruction and the promotion of organized reinnervation after RLN injury.
Methods
F344 rat primary muscle progenitor cells (MPCs) were isolated. Three‐dimensional muscle constructs were created by encapsulating MPCs in type I oligomeric collagen under passive tension. Constructs were then cultured in differentiation medium (MPC control constructs) or induced to form motor endplates (MEE constructs) with neurotrophic agents. Three‐dimensional cartilage constructs were created with adipose stem cells differentiated in chondrocyte medium. The muscle and cartilage constructs were implanted into surgically created myochondral defects in the F344 rat larynx with injured or intact (control) RLN. At 1‐, 3‐, and 6‐month timepoints, videolaryngoscopy, electromyography (EMG), histology, and immunohistochemistry were used to assess outcomes.
Results
At all timepoints, cartilage‐muscle implants were well integrated into host tissue. Functionally, there was increased vocal fold adduction and EMG activity in nerve‐injured rats treated with the MEE constructs when compared to those treated with the MPC control constructs. Motor endplate‐expressing constructs had increased myofiber cross‐sectional area compared to MPC control constructs.
Conclusion
Although our laboratory previously demonstrated that muscle and cartilage constructs could be used separately for hemilaryngeal reconstruction, this study suggests combining them with the modification of MEEs rather than MPCs, resulting in improved muscle recovery after recurrent laryngeal nerve injury.
Level of Evidence
NA. Laryngoscope, 2018
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Real‐Time Light‐Guided Vocal Fold Injection: Ex Vivo Feasibility Study in a Canine Model
Objective
The transcricothyroid (CT) membrane approach is a good option for office‐based vocal fold injection (VFI). However, because the needle tip is invisible during injection using the CT approach, precise localization requires a high level of experience, and mastering this approach involves a steep learning curve. To overcome current limitations, we conceptualized a novel technique: real‐time light‐guided VFI (RL‐VFI), which enables simultaneous VFI under direct visualization of the lighted needle tip. Herein, we aimed to verify the feasibility of RL‐VFI in cadaveric canine model, simulating the setting of office‐based VFI, as well as to explore its clinical usefulness.
Study Design
Animal study.
Methods
A customized prototype device was developed. It consisted of three parts: light source, controller, and injector. Light source comprised laser diodes of two wavelengths (635 nanometers [nm], red; 532 nm, green). Four types of injector were developed using 40‐mm needles of 23‐ and 25‐gauge and optic fibers of 50 and 100 μm. ex vivo canine larynx was prepared for the experiment. Flexible laryngoscopy system was used to examine canine vocal folds.
Results
Various routes from three insertion points (3 mm, 10 mm, and 17 mm from the midline) were validated using the device. Regardless of the injection routes, the location of the needle tip was accurately indicated by light. RL‐VFI was feasible under light guidance without difficulties. Moreover, precise and simultaneous re‐injection could be performed at the intended point using the device.
Conclusion
We introduced RL‐VFI using our customized prototype device in an ex vivo canine larynx, simulating the setting of office‐based VFI. Clinical application of RL‐VFI will improve safety and precision of CT approach, as well as expand its applications in laryngology.
Level of Evidence
NA. Laryngoscope, 2018
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Regarding Primary Surgery Versus Primary Radiation‐Based Treatment for Locally Advanced Oropharyngeal Cancer
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Regarding Primary Surgery Versus Primary Radiation‐Based Treatment for Locally Advanced Oropharyngeal Cancer
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Who's Spotting HPV-Related Cancer In Men? - Spectrum News
Who's Spotting HPV-Related Cancer In Men? Spectrum News
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SPECTRUM NEWS VIDEO: There's a particular cancer showing up more in our fathers, husbands, and adult sons: a disturbing spike in the rate of head and ...
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Turkey's new locally made cancer drug counts down to launch - Daily Sabah
Turkey's new locally made cancer drug counts down to launch Daily Sabah
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Clinical trials are set to start soon for Turkey's first locally made cancer drug in the latest initiative to decrease the country's dependence on imports.
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Who's Spotting HPV-Related Cancer In Men? - Spectrum News
Who's Spotting HPV-Related Cancer In Men? Spectrum News
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SPECTRUM NEWS VIDEO: There's a particular cancer showing up more in our fathers, husbands, and adult sons: a disturbing spike in the rate of head and ...
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MAPS & ITEC Cohorts: 6-8 Years Follow-up
Conditions: Immunotherapy; Allergy and Immunology; Asthma Interventions: Drug: House dust-mite SLIT; Drug: Normal saline Sponsors: University of Southampton; Isle of Wight NHS Trust Recruiting (Source: ClinicalTrials.gov)
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Effect of the Nasal Gel " Nascum ®-Plus " on Allergic Symptoms
Condition: Rhinitis, Allergic, Seasonal Interventions: Drug: Nascum Plus; Other: ACC Sponsors: Fraunhofer-Institute of Toxicology and Experimental Medicine; M et P Pharma AG Enrolling by invitation (Source: ClinicalTrials.gov)
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Development of Metabolic Syndrome in Children and Adolescents With Leukemia and Lymphomas
Condition: Metabolic Syndrome Intervention: Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology Recruiting (Source: ClinicalTrials.gov)
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Hearing Aid Noise Reduction in Pediatric Users (Oticon Study)
Conditions: Hearing Impairment; Hearing Loss, Sensorineural Interventions: Device: Oticon OpenSound Navigator speech enhancement algorithm; Device: Oticon omni-directional microphone algorithm Sponsors: Children's Hospital Medical Center, Cincinnati; Oticon Recruiting (Source: ClinicalTrials.gov)
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DOT Diary Longitudinal Pilot
Conditions: Adherence, Medication; Risk Behavior; Pre-Exposure Prophylaxis; HIV Prevention Interventions: Drug: Emtricitabine / Tenofovir Disoproxil Oral Tablet; Other: DOT Diary mobile app Sponsors: Public Health Foundation Enterprises, Inc.; National Institute of Mental Health (NIMH); San Francisco Department of Public Health; Emory University; AiCure; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Pilot Study of Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube
Conditions: Fallopian Tube Cancer; Fallopian Tube Infection Intervention: Drug: Aspirin 81 mg Sponsor: University of Oklahoma Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemic Mastocytosis
Condition: Indolent Systemic Mastocytosis Interventions: Other: Placebo; Biological: Sarilumab Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional Cure
Condition: HIV Infections Interventions: Biological: a1DC + inactivated whole autologous HIV; Biological: a1DC + conserved HIV peptides; Biological: a1DC + no antigen; Biological: pgDC + inactivated whole autologous HIV; Biological: pgDC + conserved HIV peptides; Biological: pgDC + no antigen Sponsors: Sharon Riddler; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Study: 15 percent of babies exposed to Zika before birth had severe abnormalities in first 18 months of life
This study was supported by the National Institutes of Health 's National Institute of Allergy and Infectious Diseases and National Eye Institute, the Thrasher Research Fund, the Bill and Melinda Gates Foundation Grand Challenges Explorations, and grants from government agencies and other funders in Brazil. (Source: UCLA Newsroom: Health Sciences)
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Medical News Today: What causes patches of dry skin?
Many common issues can cause patches of dry skin, including cold weather, allergies, and certain medical conditions, including eczema and psoriasis. In this article, we look at symptoms, treatments, and pictures of dry skin patches. (Source: Health News from Medical News Today)
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Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemic Mastocytosis
Condition: Indolent Systemic Mastocytosis Interventions: Other: Placebo; Biological: Sarilumab Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Effect of the Nasal Gel " Nascum ®-Plus " on Allergic Symptoms
Condition: Rhinitis, Allergic, Seasonal Interventions: Drug: Nascum Plus; Other: ACC Sponsors: Fraunhofer-Institute of Toxicology and Experimental Medicine; M et P Pharma AG Enrolling by invitation (Source: ClinicalTrials.gov)
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Cetirizine Chewable Bioequivalence and Food Effect Study
Condition: Allergy Interventions: Drug: Cetirizine 10mg; Drug: Cetirizine 10 mg; Drug: Ceterizine 10 mg Sponsor: Johnson& Johnson Consumer Inc., McNeil Consumer Healthcare Division Not yet recruiting (Source: ClinicalTrials.gov)
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MAPS & ITEC Cohorts: 6-8 Years Follow-up
Conditions: Immunotherapy; Allergy and Immunology; Asthma Interventions: Drug: House dust-mite SLIT; Drug: Normal saline Sponsors: University of Southampton; Isle of Wight NHS Trust Recruiting (Source: ClinicalTrials.gov)
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Development of Metabolic Syndrome in Children and Adolescents With Leukemia and Lymphomas
Condition: Metabolic Syndrome Intervention: Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology Recruiting (Source: ClinicalTrials.gov)
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Hearing Aid Noise Reduction in Pediatric Users (Oticon Study)
Conditions: Hearing Impairment; Hearing Loss, Sensorineural Interventions: Device: Oticon OpenSound Navigator speech enhancement algorithm; Device: Oticon omni-directional microphone algorithm Sponsors: Children's Hospital Medical Center, Cincinnati; Oticon Recruiting (Source: ClinicalTrials.gov)
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Pilot Study of Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube
Conditions: Fallopian Tube Cancer; Fallopian Tube Infection Intervention: Drug: Aspirin 81 mg Sponsor: University of Oklahoma Not yet recruiting (Source: ClinicalTrials.gov)
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DOT Diary Longitudinal Pilot
Conditions: Adherence, Medication; Risk Behavior; Pre-Exposure Prophylaxis; HIV Prevention Interventions: Drug: Emtricitabine / Tenofovir Disoproxil Oral Tablet; Other: DOT Diary mobile app Sponsors: Public Health Foundation Enterprises, Inc.; National Institute of Mental Health (NIMH); San Francisco Department of Public Health; Emory University; AiCure; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Study: 15 percent of babies exposed to Zika before birth had severe abnormalities in first 18 months of life
This study was supported by the National Institutes of Health 's National Institute of Allergy and Infectious Diseases and National Eye Institute, the Thrasher Research Fund, the Bill and Melinda Gates Foundation Grand Challenges Explorations, and grants from government agencies and other funders in Brazil. (Source: UCLA Newsroom: Health Sciences)
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Medical News Today: What causes patches of dry skin?
Many common issues can cause patches of dry skin, including cold weather, allergies, and certain medical conditions, including eczema and psoriasis. In this article, we look at symptoms, treatments, and pictures of dry skin patches. (Source: Health News from Medical News Today)
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Hoosick Falls native produces PFAS documentary - Bennington Banner
Hoosick Falls native produces PFAS documentary Bennington Banner
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HOOSICK FALLS, N.Y. — A Hoosick Falls native says he was inspired by PFAS contamination of water supplies in his home town to create a documentary he ...
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Study: 15 percent of babies exposed to Zika before birth had severe abnormalities in first 18 months of life
This study was supported by the National Institutes of Health 's National Institute of Allergy and Infectious Diseases and National Eye Institute, the Thrasher Research Fund, the Bill and Melinda Gates Foundation Grand Challenges Explorations, and grants from government agencies and other funders in Brazil. (Source: UCLA Newsroom: Health Sciences)
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Reviewing Vermillion (NASDAQ:VRML) and Response Genetics (RGDXQ) - PressOracle
Response Genetics (OTCMKTS:RGDXQ) and Vermillion (NASDAQ:VRML) are both small-cap medical companies, but which is the better business? We will ...
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Medical News Today: What causes patches of dry skin?
Many common issues can cause patches of dry skin, including cold weather, allergies, and certain medical conditions, including eczema and psoriasis. In this article, we look at symptoms, treatments, and pictures of dry skin patches. (Source: Health News from Medical News Today)
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Study: 15 percent of babies exposed to Zika before birth had severe abnormalities in first 18 months of life
This study was supported by the National Institutes of Health 's National Institute of Allergy and Infectious Diseases and National Eye Institute, the Thrasher Research Fund, the Bill and Melinda Gates Foundation Grand Challenges Explorations, and grants from government agencies and other funders in Brazil. (Source: UCLA Newsroom: Health Sciences)
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Reviewing Vermillion (NASDAQ:VRML) and Response Genetics (RGDXQ) - PressOracle
Response Genetics (OTCMKTS:RGDXQ) and Vermillion (NASDAQ:VRML) are both small-cap medical companies, but which is the better business? We will ...
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Hoosick Falls native produces PFAS documentary - Bennington Banner
Hoosick Falls native produces PFAS documentary Bennington Banner
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HOOSICK FALLS, N.Y. — A Hoosick Falls native says he was inspired by PFAS contamination of water supplies in his home town to create a documentary he ...
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Τετάρτη 12 Δεκεμβρίου 2018
Obesity at fault for one quarter of cancers worldwide, study says - UPI News
- Obesity at fault for one quarter of cancers worldwide, study says UPI News
- Excess body weight responsible for nearly 4 percent of cancers worldwide: Prevalence has increased rapidly in most countries across all population groups Science Daily
- Excess body weight responsible for nearly four percent of cancers worldwide Medical Xpress
- View full coverage on Google News
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CMS launches tool that prices surgeries for patients - UPI News
CMS launches tool that prices surgeries for patients UPI News
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Nov. 27 (UPI) -- The Centers for Medicare and Medicaid Services, or CMS, on Tuesday unveiled a new online tool that gives consumers the power to compare ...
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Lose-dose aspirin may help fight MS, study with mice says - UPI News
TUESDAY, Nov. 27, 2018 -- Although the findings are so far only in mice, studies suggest that aspirin -- even the "low-dose" variety -- might help counter multiple ...
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Multicenter prospective study on the use and outcome of rehabilitation after total laryngectomy in Germany
Abstract
Background
The purpose of this study was to assess the use and outcome of rehabilitation after total laryngectomy in Germany.
Methods
We enrolled patients who were scheduled for total laryngectomy, approached them again after surgery, after 3 months and 1 year. Patients completed questionnaires and were interviewed.
Results
Of 309 participants, 14% had not received any rehabilitation. Reasons for nonuse were primarily ongoing treatment and poor health. Users of rehabilitation had 4 times the odds of attaining any ability to speak compared to nonusers (odds ratio 3.8, P = .02). The main aim of rehabilitation from the perspective of the users was speech rehabilitation, mentioned by 71% before starting rehabilitation. This was also what most users (27%) found the most helpful part of rehabilitation.
Conclusions
Patients are interested in attending rehabilitation. They especially want to improve their speech capacity, which indeed is better among users of rehabilitation than in those without.
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CMS launches tool that prices surgeries for patients - UPI News
CMS launches tool that prices surgeries for patients UPI News
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Nov. 27 (UPI) -- The Centers for Medicare and Medicaid Services, or CMS, on Tuesday unveiled a new online tool that gives consumers the power to compare ...
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Obesity at fault for one quarter of cancers worldwide, study says - UPI News
- Obesity at fault for one quarter of cancers worldwide, study says UPI News
- Excess body weight responsible for nearly 4 percent of cancers worldwide: Prevalence has increased rapidly in most countries across all population groups Science Daily
- Excess body weight responsible for nearly four percent of cancers worldwide Medical Xpress
- View full coverage on Google News
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Lose-dose aspirin may help fight MS, study with mice says - UPI News
TUESDAY, Nov. 27, 2018 -- Although the findings are so far only in mice, studies suggest that aspirin -- even the "low-dose" variety -- might help counter multiple ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AweaRB
Multicenter prospective study on the use and outcome of rehabilitation after total laryngectomy in Germany
Abstract
Background
The purpose of this study was to assess the use and outcome of rehabilitation after total laryngectomy in Germany.
Methods
We enrolled patients who were scheduled for total laryngectomy, approached them again after surgery, after 3 months and 1 year. Patients completed questionnaires and were interviewed.
Results
Of 309 participants, 14% had not received any rehabilitation. Reasons for nonuse were primarily ongoing treatment and poor health. Users of rehabilitation had 4 times the odds of attaining any ability to speak compared to nonusers (odds ratio 3.8, P = .02). The main aim of rehabilitation from the perspective of the users was speech rehabilitation, mentioned by 71% before starting rehabilitation. This was also what most users (27%) found the most helpful part of rehabilitation.
Conclusions
Patients are interested in attending rehabilitation. They especially want to improve their speech capacity, which indeed is better among users of rehabilitation than in those without.
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3D printing anatomical models of head bones
Abstract
Purpose
In many medical schools, the study of Anatomy is becoming increasingly theoretical owing to the difficulty of having human body parts available, rather than offering the students the possibility of a more realistic and practical approach. We developed a project where we use a 3D printer to produce models of the human skull bones, with high quality and quantity to satisfy the needs for Anatomy classes and to be available for request to study at home.
Methods
We selected regular and well-shaped bones of the head upon which we based the 3D models. These bones were scanned using a 64-channel Computed Tomography (high-resolution volumetric acquisition) and the resulting images were then processed with a segmentation software to isolate and reconstruct the structures of interest. The final digital three-dimensional objects were converted into a printable file that the 3D printer could read. We used two filament extrusion type 3D printers, the Prusa i3 and the Zortrax M200.
Results
We have printed successfully several models of the skull bones, such as the temporal, occipital, and sphenoid. All the models have obtained good anatomical detail, thus demonstrating the practicality of this technology. Key aspects of the CT image post-processing are discussed. The production process is cost-effective and technically accessible.
Conclusions
These results confirm the potential of 3D printing to create more complex models (e.g. regional, vascular, nervous system structures) that would allow a similar experience compared with a dissection.
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