Κυριακή 23 Δεκεμβρίου 2018

Move Over, Air Filter. Scientists Have a Greener Idea

Title: Move Over, Air Filter. Scientists Have a Greener IdeaCategory: Health NewsCreated: 12/20/2018 12:00:00 AMLast Editorial Review: 12/21/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Move Over, Air Filter. Scientists Have a Greener Idea

Title: Move Over, Air Filter. Scientists Have a Greener IdeaCategory: Health NewsCreated: 12/20/2018 12:00:00 AMLast Editorial Review: 12/21/2018 12:00:00 AM (Source: MedicineNet Allergies General)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELNgsG

Move Over, Air Filter. Scientists Have a Greener Idea

Title: Move Over, Air Filter. Scientists Have a Greener IdeaCategory: Health NewsCreated: 12/20/2018 12:00:00 AMLast Editorial Review: 12/21/2018 12:00:00 AM (Source: MedicineNet Allergies General)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELNgsG

Move Over, Air Filter. Scientists Have a Greener Idea

Title: Move Over, Air Filter. Scientists Have a Greener IdeaCategory: Health NewsCreated: 12/20/2018 12:00:00 AMLast Editorial Review: 12/21/2018 12:00:00 AM (Source: MedicineNet Allergies General)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELNgsG

Carotid body tumor with hidden internal carotid artery aneurysm

Abstract

Background

The most common head and neck paraganglioma is the carotid body paraganglioma. Treatment of carotid body tumors is primarily surgical, and uncontrolled growth leads to cranial nerve deficits and more morbid resection.

Methods

A 60‐year‐old man was referred for evaluation of carotid body tumor, and workup revealed an internal carotid artery (ICA) aneurysm within the known mass.

Results

Interventional Radiology performed angiogram and stenting across aneurysm with interval dramatic reduction in size of mass, and surgery was avoided altogether.

Conclusions

Surgical resection is indicated for carotid body paragangliomas when the patient can tolerate the surgery and when the tumor was not very advanced. This patient had a small tumor that initially appeared easily resectable. Failure to detect the ICA aneurysm before resection may have resulted in devastating vascular injury and possible stroke or death. Identification of underlying vascular pathology is essential for safe treatment and should be prioritized, especially considering this case.



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Carotid body tumor with hidden internal carotid artery aneurysm

Abstract

Background

The most common head and neck paraganglioma is the carotid body paraganglioma. Treatment of carotid body tumors is primarily surgical, and uncontrolled growth leads to cranial nerve deficits and more morbid resection.

Methods

A 60‐year‐old man was referred for evaluation of carotid body tumor, and workup revealed an internal carotid artery (ICA) aneurysm within the known mass.

Results

Interventional Radiology performed angiogram and stenting across aneurysm with interval dramatic reduction in size of mass, and surgery was avoided altogether.

Conclusions

Surgical resection is indicated for carotid body paragangliomas when the patient can tolerate the surgery and when the tumor was not very advanced. This patient had a small tumor that initially appeared easily resectable. Failure to detect the ICA aneurysm before resection may have resulted in devastating vascular injury and possible stroke or death. Identification of underlying vascular pathology is essential for safe treatment and should be prioritized, especially considering this case.



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Simulation‐Guided Tracheotomy in a Patient With Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare disorder that causes heterotopic bone formation leading to chest wall and spinal deformities. This case describes an 11‐year‐old female with FOP who presented in respiratory failure necessitating two emergent fiberoptic nasotracheal intubations. The patient had severe trismus, rotary flexion of the neck, and distortion of the airway. A three‐dimensional printed model based off of a computed tomography reconstruction was created for an in situ simulation before the true procedure. The surgery and trach change were both uneventful. We propose that with careful preoperative planning, tracheotomy can be an appropriate option for FOP patients. Laryngoscope, 2018



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Simulation‐Guided Tracheotomy in a Patient With Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare disorder that causes heterotopic bone formation leading to chest wall and spinal deformities. This case describes an 11‐year‐old female with FOP who presented in respiratory failure necessitating two emergent fiberoptic nasotracheal intubations. The patient had severe trismus, rotary flexion of the neck, and distortion of the airway. A three‐dimensional printed model based off of a computed tomography reconstruction was created for an in situ simulation before the true procedure. The surgery and trach change were both uneventful. We propose that with careful preoperative planning, tracheotomy can be an appropriate option for FOP patients. Laryngoscope, 2018



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VEGF -2549 -2567 del18 polymorphism and irreversible bronchoconstriction in asthmatics.

CONCLUSIONS: Our results showed that the presence of del18 genotype at -2549 -2567 position in the promoter of VEGF gene, along with disease duration and other factors like cigarette smoking, associate with the risk of irreversible bronchoconstriction in asthmatics. PMID: 30574871 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)

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Relationship between air pollution, meteorological factors and grass pollen counts, with seasonal allergic rhinitis in Madrid (1996 and 2009).

CONCLUSIONS: The effect of the temperature and pollution (mainly O3, even at lower atmospheric concentrations than the established guidelines about its effects on health), could contributed to the observed higher seasonal allergic rhinitis symptom score in 2009. PMID: 30574872 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)

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VEGF -2549 -2567 del18 polymorphism and irreversible bronchoconstriction in asthmatics.

CONCLUSIONS: Our results showed that the presence of del18 genotype at -2549 -2567 position in the promoter of VEGF gene, along with disease duration and other factors like cigarette smoking, associate with the risk of irreversible bronchoconstriction in asthmatics. PMID: 30574871 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)

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Relationship between air pollution, meteorological factors and grass pollen counts, with seasonal allergic rhinitis in Madrid (1996 and 2009).

CONCLUSIONS: The effect of the temperature and pollution (mainly O3, even at lower atmospheric concentrations than the established guidelines about its effects on health), could contributed to the observed higher seasonal allergic rhinitis symptom score in 2009. PMID: 30574872 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)

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"Med Oral Patol Oral Cir Bucal"[jour]; +17 new citations

17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

"Med Oral Patol Oral Cir Bucal"[jour]

These pubmed results were generated on 2018/12/23

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.



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"Med Oral Patol Oral Cir Bucal"[jour]; +17 new citations

17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

"Med Oral Patol Oral Cir Bucal"[jour]

These pubmed results were generated on 2018/12/23

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwT200

Inflammation and allergic disease: An irrefutable combination



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEJSx

A cross-sectional study of the prevalence of food allergies among children younger than ages 14 years in a Beijing urban region



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Clinical updates in aspirin-exacerbated respiratory disease



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New and evolving therapies for hereditary angioedema



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Update on peanut allergy: Prevention and immunotherapy



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEJC1

Clinical burden of asynchrony in patients with asthma when using metered-dose inhalers for control



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AfedSz

Effect of inhaled corticosteroids on serum periostin levels in adult patients with mild-moderate asthma



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEGGl

Systemic reaction rates with omalizumab, subcutaneous immunotherapy, and combination therapy in children with allergic asthma



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AgWb2i

Anaphylaxis risk factors for hospitalization and intensive care: A comparison between adults and children in an upstate New York emergency department



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEEyd

A cross-sectional, population-based survey of U.S. adults with symptoms of chronic rhinosinusitis



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AdK0mR

Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SkxJ7s

Pearls and pitfalls of food challenges in infants



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For the Patient



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Abstracts presented at the New England Society of Allergy, October 20‐21, 2018, Plymouth MA



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AeC9FH

Inflammation and allergic disease: An irrefutable combination



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEJSx

A cross-sectional study of the prevalence of food allergies among children younger than ages 14 years in a Beijing urban region



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ad4egu

Clinical updates in aspirin-exacerbated respiratory disease



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SjuOM0

New and evolving therapies for hereditary angioedema



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AeCect

Update on peanut allergy: Prevention and immunotherapy



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEJC1

Clinical burden of asynchrony in patients with asthma when using metered-dose inhalers for control



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AfedSz

Effect of inhaled corticosteroids on serum periostin levels in adult patients with mild-moderate asthma



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEGGl

Systemic reaction rates with omalizumab, subcutaneous immunotherapy, and combination therapy in children with allergic asthma



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AgWb2i

Anaphylaxis risk factors for hospitalization and intensive care: A comparison between adults and children in an upstate New York emergency department



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEEyd

A cross-sectional, population-based survey of U.S. adults with symptoms of chronic rhinosinusitis



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AdK0mR

Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SkxJ7s

Pearls and pitfalls of food challenges in infants



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AgW5Yu

For the Patient



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SiR1tJ

Abstracts presented at the New England Society of Allergy, October 20‐21, 2018, Plymouth MA



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AeC9FH

Rise and be surprised: Aspectual profilingand mirativity in Odia light verb constructions

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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Rise and be surprised: Aspectual profilingand mirativity in Odia light verb constructions

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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The Consortium for Food Allergy Research (CoFAR) The First Generation

The Consortium for Food Allergy Research (CoFAR) was established by the The National Institute of Allergy and Infectious Diseases (NIAID) in 2005 as a collaborative research program bringing together centers focused on the study of food allergy. The Consortium was charged with developing studies to better understand the pathogenesis and natural history of food allergy, as well as potential approaches to the treatment of food allergy. In its first iteration, an observational study of infants with milk and egg allergy was established and studies of oral immunotherapy for egg allergy and sublingual immunotherapy for peanut allergy were initiated, as was a Phase 1 study of a recombinant peanut protein vaccine.

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The Consortium for Food Allergy Research (CoFAR) The First Generation

The Consortium for Food Allergy Research (CoFAR) was established by the The National Institute of Allergy and Infectious Diseases (NIAID) in 2005 as a collaborative research program bringing together centers focused on the study of food allergy. The Consortium was charged with developing studies to better understand the pathogenesis and natural history of food allergy, as well as potential approaches to the treatment of food allergy. In its first iteration, an observational study of infants with milk and egg allergy was established and studies of oral immunotherapy for egg allergy and sublingual immunotherapy for peanut allergy were initiated, as was a Phase 1 study of a recombinant peanut protein vaccine.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2V9MBHg

Multivector functioning muscle transfer using superficial subslips of the serratus anterior muscle for longstanding facial paralysis

Various donor muscles have been identified for restoring facial function due to longstanding facial paralysis. Donor muscles, such as the gracilis and latissimus dorsi, are frequently used and often produce one or two reliable vectors of force. There are drawbacks to using these muscles including the instability of separating multivector functioning muscle units and limited amount of muscle contraction. Serratus anterior muscle transfer has the advantages of multiple independently functioning motor units that can be created with a single neurovascular pedicle.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SjmN9S

Multivector functioning muscle transfer using superficial subslips of the serratus anterior muscle for longstanding facial paralysis

Various donor muscles have been identified for restoring facial function due to longstanding facial paralysis. Donor muscles, such as the gracilis and latissimus dorsi, are frequently used and often produce one or two reliable vectors of force. There are drawbacks to using these muscles including the instability of separating multivector functioning muscle units and limited amount of muscle contraction. Serratus anterior muscle transfer has the advantages of multiple independently functioning motor units that can be created with a single neurovascular pedicle.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SjmN9S

Squamous cell carcinoma of the tongue in a patient with dyskeratosis congenita: a rare entity

Dyskeratosis congenita is a rare genetic disorder that results from progressive failure of the bone marrow. It presents with a classic triad of reticular pigmentations of the skin, dystrophic nails, and oral leukoplakia; patients rarely develop cancers. We report a patient with dyskeratosis congenita who presented with squamous cell carcinoma of the oral tongue.

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Are large movements a risk factor for subsequent plate removal in bilateral sagittal split osteotomy?

Background: Metal plate removal is a common complication of mandibular osteotomy with up to 27.5% of patients requiring removal of some or all of their hardware. However, little is known about the risk factors for removal. We hypothesised that large advances and setbacks may result in stretching of overlying soft tissues which could increase risk of dehiscence and infection, and hence plate removal.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELvjLJ

Squamous cell carcinoma of the tongue in a patient with dyskeratosis congenita: a rare entity

Dyskeratosis congenita is a rare genetic disorder that results from progressive failure of the bone marrow. It presents with a classic triad of reticular pigmentations of the skin, dystrophic nails, and oral leukoplakia; patients rarely develop cancers. We report a patient with dyskeratosis congenita who presented with squamous cell carcinoma of the oral tongue.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EFDrwC

Are large movements a risk factor for subsequent plate removal in bilateral sagittal split osteotomy?

Background: Metal plate removal is a common complication of mandibular osteotomy with up to 27.5% of patients requiring removal of some or all of their hardware. However, little is known about the risk factors for removal. We hypothesised that large advances and setbacks may result in stretching of overlying soft tissues which could increase risk of dehiscence and infection, and hence plate removal.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELvjLJ

UK Scientist Speaks Out About the Dangers of Aluminum Adjuvants in Vaccinations

Expert scientist is concerned about the use of aluminum adjuvants in childhood vaccinations. VacTruth.com (Source: vactruth.com)

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Food Allergies and Holiday Meal Planning

When planning your holiday meals this season, you may have to keep in mind friends or family members with a food allergy or intolerance. Allergic reactions might include itching, abdominal cramps, drop in blood pressure or trouble breathing. Learn how to avoid cross-contamination when cooking and how to manage food allergies on the food allergy health topic page from MedlinePlus, the National Library of Medicine's trusted consumer health information resource. (Source: BHIC)

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UK Scientist Speaks Out About the Dangers of Aluminum Adjuvants in Vaccinations

Expert scientist is concerned about the use of aluminum adjuvants in childhood vaccinations. VacTruth.com (Source: vactruth.com)

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Food Allergies and Holiday Meal Planning

When planning your holiday meals this season, you may have to keep in mind friends or family members with a food allergy or intolerance. Allergic reactions might include itching, abdominal cramps, drop in blood pressure or trouble breathing. Learn how to avoid cross-contamination when cooking and how to manage food allergies on the food allergy health topic page from MedlinePlus, the National Library of Medicine's trusted consumer health information resource. (Source: BHIC)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EG7RPb

Prevalence and Incidence of Lassa Virus Infection in Southern Mali

Condition:   Lassa Virus Infection Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Dose, Safety, Tolerability, and Immunogenicity of an HIV-1 Vaccine, VRC-HIVRGP096-00-VP, With Alum in Healthy Adults < TAB >

Condition:   Human Immunodeficiency Virus (HIV) Intervention:   Biological: VRC-HIVRGP096-00-VP Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.



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Identification of Allergic Asthmatics Reactive to Felis Catus (Cat Hair) Allergen Inhalation

Condition:   Asthma Atopic Intervention:   Biological: Felis Catus Sponsors:   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI) Not yet recruiting (Source: ClinicalTrials.gov)

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Therapeutic Drug Monitoring of Tocilizumab in Rheumatoid Arthritis

Conditions:   Rheumatoid Arthritis;   Tocilizumab Intervention:   Drug: Tocilizumab Sponsors:   Tel-Aviv Sourasky Medical Center;   Amsterdam Rheumatology and Immunology Center Recruiting (Source: ClinicalTrials.gov)

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Safety and Efficacy of Low-dose IL-2 in Allergy to Birch Pollen

Conditions:   Allergic Rhinoconjunctivitis to Birch Pollen;   With an Apple Oral Allergic Syndrome (OAS) to Apple;   With a Positive Skin Prick Test to Birch Pollen Intervention:   Drug: ILT-101 ld-(IL2) Sponsors:   Assistance Publique - Hôpitaux de Paris;   Iltoo Pharma Not yet recruiting (Source: ClinicalTrials.gov)

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Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study

Conditions:   Sleep Apnea;   Allergic Rhinitis;   Allergic Asthma;   Pollution; Exposure;   Pollution Related Respiratory Disorder Intervention:   Other: Pollution exposure Sponsors:   University Hospital, Grenoble;   Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)

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Cetirizine Chewable Bioequivalence and Food Effect Study

Condition:   Allergy Interventions:   Drug: Cetirizine 10mg;   Drug: Cetirizine 10 mg Sponsor:   Johnson& Johnson Consumer Inc., McNeil Consumer Healthcare Division Recruiting (Source: ClinicalTrials.gov)

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DOT Diary Mobile App for Pre-Exposure Prophylaxis Adherence in Young Men

Conditions:   Adherence, Medication;   Risk Behavior;   Pre-Exposure Prophylaxis;   HIV Prevention Interventions:   Drug: Emtricitabine / Tenofovir Disoproxil Oral Tablet;   Other: DOT Diary mobile app Sponsors:   Public Health Foundation Enterprises, Inc.;   National Institute of Mental Health (NIMH);   San Francisco Department of Public Health;   Emory University;   AiCure;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Pilot Study of Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube

Conditions:   Fallopian Tube Cancer;   Fallopian Tube Infection Intervention:   Drug: Aspirin 81 mg Sponsor:   University of Oklahoma Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2s0zIlT

Prevalence and Incidence of Lassa Virus Infection in Southern Mali

Condition:   Lassa Virus Infection Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rSMin0

Dose, Safety, Tolerability, and Immunogenicity of an HIV-1 Vaccine, VRC-HIVRGP096-00-VP, With Alum in Healthy Adults < TAB >

Condition:   Human Immunodeficiency Virus (HIV) Intervention:   Biological: VRC-HIVRGP096-00-VP Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LuQzWA

Identification of Allergic Asthmatics Reactive to Felis Catus (Cat Hair) Allergen Inhalation

Condition:   Asthma Atopic Intervention:   Biological: Felis Catus Sponsors:   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rTJwOp

Therapeutic Drug Monitoring of Tocilizumab in Rheumatoid Arthritis

Conditions:   Rheumatoid Arthritis;   Tocilizumab Intervention:   Drug: Tocilizumab Sponsors:   Tel-Aviv Sourasky Medical Center;   Amsterdam Rheumatology and Immunology Center Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LuQtyc

Safety and Efficacy of Low-dose IL-2 in Allergy to Birch Pollen

Conditions:   Allergic Rhinoconjunctivitis to Birch Pollen;   With an Apple Oral Allergic Syndrome (OAS) to Apple;   With a Positive Skin Prick Test to Birch Pollen Intervention:   Drug: ILT-101 ld-(IL2) Sponsors:   Assistance Publique - Hôpitaux de Paris;   Iltoo Pharma Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rPwOQC

Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study

Conditions:   Sleep Apnea;   Allergic Rhinitis;   Allergic Asthma;   Pollution; Exposure;   Pollution Related Respiratory Disorder Intervention:   Other: Pollution exposure Sponsors:   University Hospital, Grenoble;   Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)

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Cetirizine Chewable Bioequivalence and Food Effect Study

Condition:   Allergy Interventions:   Drug: Cetirizine 10mg;   Drug: Cetirizine 10 mg Sponsor:   Johnson& Johnson Consumer Inc., McNeil Consumer Healthcare Division Recruiting (Source: ClinicalTrials.gov)

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DOT Diary Mobile App for Pre-Exposure Prophylaxis Adherence in Young Men

Conditions:   Adherence, Medication;   Risk Behavior;   Pre-Exposure Prophylaxis;   HIV Prevention Interventions:   Drug: Emtricitabine / Tenofovir Disoproxil Oral Tablet;   Other: DOT Diary mobile app Sponsors:   Public Health Foundation Enterprises, Inc.;   National Institute of Mental Health (NIMH);   San Francisco Department of Public Health;   Emory University;   AiCure;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Pilot Study of Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube

Conditions:   Fallopian Tube Cancer;   Fallopian Tube Infection Intervention:   Drug: Aspirin 81 mg Sponsor:   University of Oklahoma Not yet recruiting (Source: ClinicalTrials.gov)

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International symposium defines the future role of oral physicians

Abstract

On 7 October 2017, an international forward‐looking symposium for approximately 800 dental personnel entitled "Dentistry in the future ‐ through information from different countries" was held in Sakata, Japan. The contents of the 12th annual symposium were full of significant indications and suggestions on future healthcare which we think are worth reporting.

This article is protected by copyright. All rights reserved.



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International symposium defines the future role of oral physicians

Abstract

On 7 October 2017, an international forward‐looking symposium for approximately 800 dental personnel entitled "Dentistry in the future ‐ through information from different countries" was held in Sakata, Japan. The contents of the 12th annual symposium were full of significant indications and suggestions on future healthcare which we think are worth reporting.

This article is protected by copyright. All rights reserved.



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Alteration of FDG uptake by performing novel object recognition task in a rat model of Traumatic Brain Injury

Publication date: March 2019

Source: NeuroImage, Volume 188

Author(s): Shalini Jaiswal, Nicole Hockenbury, Hongna Pan, Andrew Knutsen, Bernard J. Dardzinski, Kimberly R. Byrnes

Abstract

Traumatic Brain Injury (TBI) affects approximately 2.5 million people in the United States, of which 80% are considered to be mild (mTBI). Previous studies have shown that cerebral glucose uptake and metabolism are altered after brain trauma and functional metabolic deficits observed following mTBI are associated with changes in cognitive performance. Imaging of glucose uptake using [18F] Fluorodeoxyglucose (FDG) based Positron Emission Tomography (PET) with anesthesia during the uptake period demonstrated limited variability in results, but may have depressed uptake. Anesthesia has been found to interfere with blood glucose levels, and hence, FDG uptake. Conversely, forced cognitive testing during uptake may increase glucose demand in targeted regions, such as hippocampus, allowing for better differentiation of outcomes. Therefore, the objective of this study was to investigate the influence of a directed cognitive function task during the FDG uptake period on uptake measurements both in naïve rats and at 2 days after mild lateral fluid percussion (mLFP) TBI. Adult male Sprague Dawley rats underwent FDG uptake with either cognitive testing with the Novel Object Recognition (NOR) test or No Novel Object (NNO), followed by PET scans at baseline (prior to injury) and at 2days post mLFP. At baseline, FDG uptake in the right hippocampus was elevated in rats completing the NOR in comparison to the NNO (control group). Further, the NNO group rats demonstrated a greater fold change in the FDG uptake between baseline and post injury scans than the NOR group. Overall, these data suggest that cognitive activity during FDG uptake affects the regional uptake pattern in the brain, increasing uptake at baseline and suppressing the effects of injury.



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Alteration of FDG uptake by performing novel object recognition task in a rat model of Traumatic Brain Injury

Publication date: March 2019

Source: NeuroImage, Volume 188

Author(s): Shalini Jaiswal, Nicole Hockenbury, Hongna Pan, Andrew Knutsen, Bernard J. Dardzinski, Kimberly R. Byrnes

Abstract

Traumatic Brain Injury (TBI) affects approximately 2.5 million people in the United States, of which 80% are considered to be mild (mTBI). Previous studies have shown that cerebral glucose uptake and metabolism are altered after brain trauma and functional metabolic deficits observed following mTBI are associated with changes in cognitive performance. Imaging of glucose uptake using [18F] Fluorodeoxyglucose (FDG) based Positron Emission Tomography (PET) with anesthesia during the uptake period demonstrated limited variability in results, but may have depressed uptake. Anesthesia has been found to interfere with blood glucose levels, and hence, FDG uptake. Conversely, forced cognitive testing during uptake may increase glucose demand in targeted regions, such as hippocampus, allowing for better differentiation of outcomes. Therefore, the objective of this study was to investigate the influence of a directed cognitive function task during the FDG uptake period on uptake measurements both in naïve rats and at 2 days after mild lateral fluid percussion (mLFP) TBI. Adult male Sprague Dawley rats underwent FDG uptake with either cognitive testing with the Novel Object Recognition (NOR) test or No Novel Object (NNO), followed by PET scans at baseline (prior to injury) and at 2days post mLFP. At baseline, FDG uptake in the right hippocampus was elevated in rats completing the NOR in comparison to the NNO (control group). Further, the NNO group rats demonstrated a greater fold change in the FDG uptake between baseline and post injury scans than the NOR group. Overall, these data suggest that cognitive activity during FDG uptake affects the regional uptake pattern in the brain, increasing uptake at baseline and suppressing the effects of injury.



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In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

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The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.



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Differential impact of age on survival in head and neck cancer according to classic Cox regression and decision tree analysis

Abstract

Objectives

To assess the impact of age on the survival of patients with head and neck squamous cell carcinoma (HNSCC) using different statistical methods.

Design

A retrospective population based study.

Setting

Surveillance, Epidemiology, and End Results database.

Subjects and methods

A total of 28639 patients with newly diagnosed HNSCC were enrolled between January 1, 2007, and December 31, 2013. The effect of age on 5‐year disease‐specific survival was calculated using a Kaplan‐Meier method and compared using log‐rank tests. A Cox proportional hazards model was used for a multivariate analysis. A classification and regression tree (CART) analysis that partitioned patients with significantly different Kaplan‐Meier curves was introduced to identify the important cancer‐related parameters influencing survival.

Results

Uni‐ and multivariate analyses indicated that patients who were older than 60 years had poorer 5‐year disease‐specific survival regardless of tumor subsite and TNM stage. However, the CART analysis determined that age played only a minor role in survival after comparing with other prognosticators. The relative importance of age using the Gini index was as follows: 3.21% for oral cancer, 8.32% for oropharyngeal cancer, 2.56% for hypopharyngeal cancer, and 16.51% for laryngeal cancer.

Conclusions

Different to traditional statistical methods, the CART analysis which was used to identify homogeneous populations, revealed that the impact of age varied for different patient groups according to the presence or absence of other prognosticators. This important information could help to guide our clinical decisions and future researches.

This article is protected by copyright. All rights reserved.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PZFbTg

Differential impact of age on survival in head and neck cancer according to classic Cox regression and decision tree analysis

Abstract

Objectives

To assess the impact of age on the survival of patients with head and neck squamous cell carcinoma (HNSCC) using different statistical methods.

Design

A retrospective population based study.

Setting

Surveillance, Epidemiology, and End Results database.

Subjects and methods

A total of 28639 patients with newly diagnosed HNSCC were enrolled between January 1, 2007, and December 31, 2013. The effect of age on 5‐year disease‐specific survival was calculated using a Kaplan‐Meier method and compared using log‐rank tests. A Cox proportional hazards model was used for a multivariate analysis. A classification and regression tree (CART) analysis that partitioned patients with significantly different Kaplan‐Meier curves was introduced to identify the important cancer‐related parameters influencing survival.

Results

Uni‐ and multivariate analyses indicated that patients who were older than 60 years had poorer 5‐year disease‐specific survival regardless of tumor subsite and TNM stage. However, the CART analysis determined that age played only a minor role in survival after comparing with other prognosticators. The relative importance of age using the Gini index was as follows: 3.21% for oral cancer, 8.32% for oropharyngeal cancer, 2.56% for hypopharyngeal cancer, and 16.51% for laryngeal cancer.

Conclusions

Different to traditional statistical methods, the CART analysis which was used to identify homogeneous populations, revealed that the impact of age varied for different patient groups according to the presence or absence of other prognosticators. This important information could help to guide our clinical decisions and future researches.

This article is protected by copyright. All rights reserved.



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A randomized controlled trial on the efficiency of free‐handed, pilot‐drill guided and fully‐guided implant surgery in partially edentulous patients

Abstract

Objectives

To compare the effectiveness of free‐handed (FH), pilot‐drill guided (PG) and fully‐guided (FG) implant surgery by means of the Apical Global Deviation (AGD) in relation to the additional financial cost and time spent.

Materials and methods

Thirty‐three partially edentulous patients in need of ≥2 implants in the posterior maxilla were randomly allocated to one of the following treatment groups: FH, PG, FG. Eleven patients (mean age 57; 8 females; altogether 26 implants) were treated by FH surgery, 11 (mean age 53; 7 females; altogether 24 implants) by PG surgery and 10 (mean age 60; 6 females; altogether 21 implants) by FG surgery. The accuracy in implant positioning was assessed by comparing the actual implant position to its planned position with the AGD as the main measure of effectiveness. Cost analysis included data on time investment (pre‐ and per‐operative) and operational cost. The efficiency of PG and FG surgery was assessed by means of the incremental cost‐effectiveness ratio (ICER), defined as the extra investment that is needed per unit reduction in AGD when compared to FH surgery.

Results

FG surgery was most effective (mean AGD: 0.97mm) and FH surgery was least effective (mean AGD: 2.11mm) in terms of surgical accuracy. As a result, 5/26 implants had to be restored with a cement‐retained restoration following FH surgery, although screw‐retention was planned for all implants in every group. The total time investment did not differ significantly between the 3 groups (p=0.811). A significant additional cost per implant was found for PG and FG as compared to FH surgery pointing to 8.29% (€176.54) and 10.45% (€222.52), respectively (p<0.001). The ICER revealed an additional cost of €5.48 and €4.12 per percent reduction in AGD for PG and FG surgery, respectively.

Conclusion

The extra operational cost for guided implant surgery is acceptable and clinically justified since cementation can be avoided. FG surgery is the most efficient surgical approach, even though the absolute operational cost is higher when compared to PG and FH surgery.

This article is protected by copyright. All rights reserved.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PYh8V0

A randomized controlled trial on the efficiency of free‐handed, pilot‐drill guided and fully‐guided implant surgery in partially edentulous patients

Abstract

Objectives

To compare the effectiveness of free‐handed (FH), pilot‐drill guided (PG) and fully‐guided (FG) implant surgery by means of the Apical Global Deviation (AGD) in relation to the additional financial cost and time spent.

Materials and methods

Thirty‐three partially edentulous patients in need of ≥2 implants in the posterior maxilla were randomly allocated to one of the following treatment groups: FH, PG, FG. Eleven patients (mean age 57; 8 females; altogether 26 implants) were treated by FH surgery, 11 (mean age 53; 7 females; altogether 24 implants) by PG surgery and 10 (mean age 60; 6 females; altogether 21 implants) by FG surgery. The accuracy in implant positioning was assessed by comparing the actual implant position to its planned position with the AGD as the main measure of effectiveness. Cost analysis included data on time investment (pre‐ and per‐operative) and operational cost. The efficiency of PG and FG surgery was assessed by means of the incremental cost‐effectiveness ratio (ICER), defined as the extra investment that is needed per unit reduction in AGD when compared to FH surgery.

Results

FG surgery was most effective (mean AGD: 0.97mm) and FH surgery was least effective (mean AGD: 2.11mm) in terms of surgical accuracy. As a result, 5/26 implants had to be restored with a cement‐retained restoration following FH surgery, although screw‐retention was planned for all implants in every group. The total time investment did not differ significantly between the 3 groups (p=0.811). A significant additional cost per implant was found for PG and FG as compared to FH surgery pointing to 8.29% (€176.54) and 10.45% (€222.52), respectively (p<0.001). The ICER revealed an additional cost of €5.48 and €4.12 per percent reduction in AGD for PG and FG surgery, respectively.

Conclusion

The extra operational cost for guided implant surgery is acceptable and clinically justified since cementation can be avoided. FG surgery is the most efficient surgical approach, even though the absolute operational cost is higher when compared to PG and FH surgery.

This article is protected by copyright. All rights reserved.



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Σάββατο 22 Δεκεμβρίου 2018

Can photolysis of the CoC bond in coenzyme B12-dependent enzymes be used to mimic the native reaction?

Publication date: Available online 21 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Abdullah Al Mamun, Megan J. Toda, Pawel M. KozlowskiAbstractCoenzyme B12 (Adenosylcobalamin = AdoCbl)-dependent enzymes catalyze complex molecular transformations where cleavage of the CoC bond initiates the catalytic cycle. Alternatively, the CoC bond can be cleaved with light. In both cases, rupture of the CoC bond results in the formation of Co(II)/Ado radical pair (RP). Within the field of B12 chemistry, there has been a suspicion that photolytic cleavage can be used as a probe or a direct comparison of the native reaction. Herein, we seek to resolve what the connection between light-induced RP formation and the native catalytic cycle is. We used a combined QM/...

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Highly efficient of molybdenum trioxide-cadmium titanate nanocomposites for ultraviolet light photocatalytic and antimicrobial application: Influence of reactive oxygen species

Publication date: Available online 21 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Jia-Ming Zhu, Mojgan Hosseini, Ali Fakhri, Saboura Salari Rad, Tayebeh Hadadi, Nastaran NobakhtAbstractIn the present work we report the enhanced UV light photocatalytic performance of cadmium titanate photocatalyst by MoO3 for Drug pollutant degradation. The nano photocatalyst sample was synthesized employing the Pechini-ultrasonic-hydrothermal route. Therefore, the nano photocatalyst were characterized by various analytical devices. The wide scan X-ray photoelectron spectral study confirmed the MoO3 in the CdTiO3 matrix. The crystallite size calculated with the Debye-Scherrer equation (55.4, 57.0, 61.2 and 63.1 nm for pure CdTiO3, MoCdTi-0, MoCdTi-1, and MoCdTi-2 n...

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Can photolysis of the CoC bond in coenzyme B12-dependent enzymes be used to mimic the native reaction?

Publication date: Available online 21 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Abdullah Al Mamun, Megan J. Toda, Pawel M. KozlowskiAbstractCoenzyme B12 (Adenosylcobalamin = AdoCbl)-dependent enzymes catalyze complex molecular transformations where cleavage of the CoC bond initiates the catalytic cycle. Alternatively, the CoC bond can be cleaved with light. In both cases, rupture of the CoC bond results in the formation of Co(II)/Ado radical pair (RP). Within the field of B12 chemistry, there has been a suspicion that photolytic cleavage can be used as a probe or a direct comparison of the native reaction. Herein, we seek to resolve what the connection between light-induced RP formation and the native catalytic cycle is. We used a combined QM/...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LyzYBl

Highly efficient of molybdenum trioxide-cadmium titanate nanocomposites for ultraviolet light photocatalytic and antimicrobial application: Influence of reactive oxygen species

Publication date: Available online 21 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Jia-Ming Zhu, Mojgan Hosseini, Ali Fakhri, Saboura Salari Rad, Tayebeh Hadadi, Nastaran NobakhtAbstractIn the present work we report the enhanced UV light photocatalytic performance of cadmium titanate photocatalyst by MoO3 for Drug pollutant degradation. The nano photocatalyst sample was synthesized employing the Pechini-ultrasonic-hydrothermal route. Therefore, the nano photocatalyst were characterized by various analytical devices. The wide scan X-ray photoelectron spectral study confirmed the MoO3 in the CdTiO3 matrix. The crystallite size calculated with the Debye-Scherrer equation (55.4, 57.0, 61.2 and 63.1 nm for pure CdTiO3, MoCdTi-0, MoCdTi-1, and MoCdTi-2 n...

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Delayed-onset facial nerve paresis following cochlear implantation: case report and literature review.

CONCLUSION: Prognosis for recovery of late-onset facial nerve paresis seems promising, despite the unfortunate requirement for device explantation in all previous cases including our own. PMID: 30565529 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)

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Delayed-onset facial nerve paresis following cochlear implantation: case report and literature review.

CONCLUSION: Prognosis for recovery of late-onset facial nerve paresis seems promising, despite the unfortunate requirement for device explantation in all previous cases including our own. PMID: 30565529 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)

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Commonwealth of Pennsylvania Public School Empls Retrmt SYS Has $1.07 Million Position in Exelixis, Inc. (EXEL) - Fairfield Current

exelixis-inc-logo.jpg

Commonwealth of Pennsylvania Public School Empls Retrmt SYS Has $1.07 Million Position in Exelixis, Inc. (EXEL)  Fairfield Current

Commonwealth of Pennsylvania Public School Empls Retrmt SYS reduced its position in shares of Exelixis, Inc. (NASDAQ:EXEL) by 20.5% during the 3rd ...



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Commonwealth of Pennsylvania Public School Empls Retrmt SYS Has $1.07 Million Position in Exelixis, Inc. (EXEL) - Fairfield Current

exelixis-inc-logo.jpg

Commonwealth of Pennsylvania Public School Empls Retrmt SYS Has $1.07 Million Position in Exelixis, Inc. (EXEL)  Fairfield Current

Commonwealth of Pennsylvania Public School Empls Retrmt SYS reduced its position in shares of Exelixis, Inc. (NASDAQ:EXEL) by 20.5% during the 3rd ...



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S. Korea changes graphic warnings on cigarette packs - Yonhap News Agency

S. Korea changes graphic warnings on cigarette packs  Yonhap News Agency

SEOUL, Dec. 23 (Yonhap) -- South Korea has changed the graphic warnings on cigarette packs in the latest move to curb smoking, the health ministry said ...



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S. Korea changes graphic warnings on cigarette packs - Yonhap News Agency

S. Korea changes graphic warnings on cigarette packs  Yonhap News Agency

SEOUL, Dec. 23 (Yonhap) -- South Korea has changed the graphic warnings on cigarette packs in the latest move to curb smoking, the health ministry said ...



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