Frito-Lay Issues Voluntary Allergy Alert on Undeclared Milk In Small Number of Stacy ’s Simply Naked Pita Chips

Frito-Lay announced a limited voluntary recall of a very small number of 7 1/3 oz. bags of Stacy 's Simply Naked Pita Chips because they may contain undeclared milk ingredients. People who have an allergy or severe sensitivity to milk run the risk of a serious or life-threatening allergic reaction if they consume the product contained inside the recalled pita chips bags. (Source: Food and Drug Administration)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Txux8O

Allergy Alert Issued by Santa Rosa Whole Foods Market for Undeclared Walnut, Milk and Eggs in “Hipster Chipster” Cookies

The Santa Rosa Whole Foods Market store is voluntarily recalling eight packages of its "Hipster Chipster" cookies because they contain undeclared tree nut (walnut), milk, and egg allergens that were not listed on the product label. (Source: Food and Drug Administration)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bmqohc

A case of minor salivary gland sialolithiasis of the upper lip

Abstract

Background

Sialolithiasis is the most common disease of the salivary glands. Sialolithiasis usually develops in the major salivary glands, and rarely in the minor salivary glands, with only 2% of all cases of sialolithiasis occurring in the minor salivary glands and sublingual glands. Sialoliths in the minor salivary glands result in few or no clinical symptoms and are seldom identified on imaging.

Case presentation

We report herein our experience with a case of minor salivary gland sialolithiasis in a 67-year-old woman. On examination, an elastic soft, mobile, and well-circumscribed mass was palpable within the left upper lip. Ultrasound examination revealed a hypoechoic mass with heterogeneous internal echoes. The mass was excised under local anesthesia. Based on histopathological findings, a diagnosis of minor salivary gland sialolithiasis was established.

Conclusions

Diagnosis of minor salivary gland sialolithiasis is challenging due to the difficulty of detecting sialoliths on imaging. A well-circumscribed mass was detected in the upper lip, and ultrasound examination revealed a round lesion, raising the suspicion of a benign tumor. Other diseases that can develop at the upper lip are calcified lymph node, phlebolith, fibroma, pleomorphic adenoma, myxoma, vascular malformation, salivary gland tumor, non-specific sialadenitis, and malignant tumor. Surgical excision is the favored approach for confirming a diagnosis of intramucosal nodular lesions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SnDODn

A case of minor salivary gland sialolithiasis of the upper lip

Abstract

Background

Sialolithiasis is the most common disease of the salivary glands. Sialolithiasis usually develops in the major salivary glands, and rarely in the minor salivary glands, with only 2% of all cases of sialolithiasis occurring in the minor salivary glands and sublingual glands. Sialoliths in the minor salivary glands result in few or no clinical symptoms and are seldom identified on imaging.

Case presentation

We report herein our experience with a case of minor salivary gland sialolithiasis in a 67-year-old woman. On examination, an elastic soft, mobile, and well-circumscribed mass was palpable within the left upper lip. Ultrasound examination revealed a hypoechoic mass with heterogeneous internal echoes. The mass was excised under local anesthesia. Based on histopathological findings, a diagnosis of minor salivary gland sialolithiasis was established.

Conclusions

Diagnosis of minor salivary gland sialolithiasis is challenging due to the difficulty of detecting sialoliths on imaging. A well-circumscribed mass was detected in the upper lip, and ultrasound examination revealed a round lesion, raising the suspicion of a benign tumor. Other diseases that can develop at the upper lip are calcified lymph node, phlebolith, fibroma, pleomorphic adenoma, myxoma, vascular malformation, salivary gland tumor, non-specific sialadenitis, and malignant tumor. Surgical excision is the favored approach for confirming a diagnosis of intramucosal nodular lesions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SnDODn

The Role of Progesterone in Cellular Apoptosis of Skin and Lung in a Bleomycin-injured Mouse Model

Systemic sclerosis is a female predominant, a fibrotic autoimmune disease in which disturbance in tissue homeostasis and cell turnover including cell apoptosis are central events in pathogenesis. Sex hormones are known as the important players in sexual dimorphism of autoimmune diseases and in tissue homeostasis. Progesterone influences autoimmune disease via its immunomodulatory effect or by its direct action on parenchymal cell function. On the other hand, this hormone impacts tissue homeostasis by acting on cell apoptosis in a different situation. The objective of this study was to examine the effect of progesterone on cellular apoptosis of skin and lung tissues in a mouse model of scleroderma. Four group of mice were involved in this study with 10 mice in each. The fibrotic model was induced by daily subcutaneous injection of bleomycin for 28 days. One week after initiation of fibrosis induction, mice received subcutaneous progesterone alone or with bleomycin for 21 days. Control group received only Phosphate buffered saline PBS. After 28 days, under lethal anesthesia skin and lung tissues were harvested for histological assessment and hydroxyproline measurement. Apoptosis in tissue sections was detected by TUNEL assay technique. Bleomycin administration induced fibrosis in skin and lung tissues. Severe apoptosis was seen in skin and lung tissues of the bleomycin-treated group (p<0.001 in the skin and p<0.05 in the lung). Progesterone injection either in the skin (p>0.05) or in the lung (p>0.05) did not alter apoptosis in bleomycin-treated animals. Our data confirm the role of apoptosis in the pathogenesis of fibrosis in this model; however, progesterone does not affect cellular apoptosis in skin and lung tissues of bleomycin-injured animals.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RCgq0k

The Role of Progesterone in Cellular Apoptosis of Skin and Lung in a Bleomycin-injured Mouse Model

Systemic sclerosis is a female predominant, a fibrotic autoimmune disease in which disturbance in tissue homeostasis and cell turnover including cell apoptosis are central events in pathogenesis. Sex hormones are known as the important players in sexual dimorphism of autoimmune diseases and in tissue homeostasis. Progesterone influences autoimmune disease via its immunomodulatory effect or by its direct action on parenchymal cell function. On the other hand, this hormone impacts tissue homeostasis by acting on cell apoptosis in a different situation. The objective of this study was to examine the effect of progesterone on cellular apoptosis of skin and lung tissues in a mouse model of scleroderma. Four group of mice were involved in this study with 10 mice in each. The fibrotic model was induced by daily subcutaneous injection of bleomycin for 28 days. One week after initiation of fibrosis induction, mice received subcutaneous progesterone alone or with bleomycin for 21 days. Control group received only Phosphate buffered saline PBS. After 28 days, under lethal anesthesia skin and lung tissues were harvested for histological assessment and hydroxyproline measurement. Apoptosis in tissue sections was detected by TUNEL assay technique. Bleomycin administration induced fibrosis in skin and lung tissues. Severe apoptosis was seen in skin and lung tissues of the bleomycin-treated group (p<0.001 in the skin and p<0.05 in the lung). Progesterone injection either in the skin (p>0.05) or in the lung (p>0.05) did not alter apoptosis in bleomycin-treated animals. Our data confirm the role of apoptosis in the pathogenesis of fibrosis in this model; however, progesterone does not affect cellular apoptosis in skin and lung tissues of bleomycin-injured animals.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RCgq0k

A Practical Approach for the Verification and Determination of Site- and Trimester-Specific Reference Intervals for Thyroid Function Tests in Pregnancy

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SnHogI

A Practical Approach for the Verification and Determination of Site- and Trimester-Specific Reference Intervals for Thyroid Function Tests in Pregnancy

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SnHogI

Creating an Easier Path for Head/Neck Cancer Patients

Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care. How did I create this pathway? The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—understood the process, what to expect and how to prepare for next steps. After deciding to create this process pathway and getting it approved by the hospital cancer board ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GoFm9E

Creating an Easier Path for Head/Neck Cancer Patients

Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care. How did I create this pathway? The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—understood the process, what to expect and how to prepare for next steps. After deciding to create this process pathway and getting it approved by the hospital cancer board ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GoFm9E

A Practical Approach for the Verification and Determination of Site- and Trimester-Specific Reference Intervals for Thyroid Function Tests in Pregnancy

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SnHogI

A Practical Approach for the Verification and Determination of Site- and Trimester-Specific Reference Intervals for Thyroid Function Tests in Pregnancy

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SnHogI

A Practical Approach for the Verification and Determination of Site- and Trimester-Specific Reference Intervals for Thyroid Function Tests in Pregnancy

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S9P8DO

A Practical Approach for the Verification and Determination of Site- and Trimester-Specific Reference Intervals for Thyroid Function Tests in Pregnancy

Thyroid, Ahead of Print.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S9P8DO

The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Menière’s disease on MRI

Abstract

Purpose

There is still a clinical-radiologic discrepancy in patients with Menière's disease (MD). Therefore, the purpose of this study was to investigate the reliability of current MRI endolymphatic hydrops (EH) criteria according to Baráth in a larger study population and the clinical utility of new imaging signs such as a supplementary fourth low-grade vestibular EH and the degree of perilymphatic enhancement (PE) in patients with Menière's disease (MD).

Methods

This retrospective study included 148 patients with probable or definite MD according to the 2015 American Academy of Otolaryngology, Head and Neck Surgery criteria who underwent a 4-h delayed intravenous Gd-enhanced 3D-FLAIR MRI between January 2015 and December 2016. Vestibular EH, vestibular PE, cochlear EH, and cochlear PE were reviewed twice by three experienced readers. Cohen's Kappa and multivariate logistic regression were used for analysis.

Results

The intra- and inter-reader reliability for the grading of vestibular-cochlear EH and PE was excellent (0.7 < kappa < 0.9). The two most distinctive characteristics to identify MD are cochlear PE and vestibular EH which combined gave a sensitivity and specificity of 79.5 and 93.6%. By addition of a lower grade vestibular EH, the sensitivity improved to 84.6% without losing specificity (92.3%). Cochlear EH nor vestibular PE showed added-value.

Conclusions

MRI using vestibular-cochlear EH and PE grading system is a reliable technique. A four-stage vestibular EH grading system in combination with cochlear PE assessment gives the best diagnostic accuracy to detect MD.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2StvwK7

The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Menière’s disease on MRI

Abstract

Purpose

There is still a clinical-radiologic discrepancy in patients with Menière's disease (MD). Therefore, the purpose of this study was to investigate the reliability of current MRI endolymphatic hydrops (EH) criteria according to Baráth in a larger study population and the clinical utility of new imaging signs such as a supplementary fourth low-grade vestibular EH and the degree of perilymphatic enhancement (PE) in patients with Menière's disease (MD).

Methods

This retrospective study included 148 patients with probable or definite MD according to the 2015 American Academy of Otolaryngology, Head and Neck Surgery criteria who underwent a 4-h delayed intravenous Gd-enhanced 3D-FLAIR MRI between January 2015 and December 2016. Vestibular EH, vestibular PE, cochlear EH, and cochlear PE were reviewed twice by three experienced readers. Cohen's Kappa and multivariate logistic regression were used for analysis.

Results

The intra- and inter-reader reliability for the grading of vestibular-cochlear EH and PE was excellent (0.7 < kappa < 0.9). The two most distinctive characteristics to identify MD are cochlear PE and vestibular EH which combined gave a sensitivity and specificity of 79.5 and 93.6%. By addition of a lower grade vestibular EH, the sensitivity improved to 84.6% without losing specificity (92.3%). Cochlear EH nor vestibular PE showed added-value.

Conclusions

MRI using vestibular-cochlear EH and PE grading system is a reliable technique. A four-stage vestibular EH grading system in combination with cochlear PE assessment gives the best diagnostic accuracy to detect MD.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2StvwK7

Congenital hypothyroidism as a risk factor for central hearing process disorders

Conclusions: The data obtained show a high frequency of lag symptoms in cognitive functions related to central auditory processing, particularly with regard to auditory attention, figure-background ability and auditory memory in patients with congenital hypothyroidism. (Source: Revista Paulista de Pediatria)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GpgLle

A case of minor salivary gland sialolithiasis of the upper lip

Abstract

Background

Sialolithiasis is the most common disease of the salivary glands. Sialolithiasis usually develops in the major salivary glands, and rarely in the minor salivary glands, with only 2% of all cases of sialolithiasis occurring in the minor salivary glands and sublingual glands. Sialoliths in the minor salivary glands result in few or no clinical symptoms and are seldom identified on imaging.

Case presentation

We report herein our experience with a case of minor salivary gland sialolithiasis in a 67-year-old woman. On examination, an elastic soft, mobile, and well-circumscribed mass was palpable within the left upper lip. Ultrasound examination revealed a hypoechoic mass with heterogeneous internal echoes. The mass was excised under local anesthesia. Based on histopathological findings, a diagnosis of minor salivary gland sialolithiasis was established.

Conclusions

Diagnosis of minor salivary gland sialolithiasis is challenging due to the difficulty of detecting sialoliths on imaging. A well-circumscribed mass was detected in the upper lip, and ultrasound examination revealed a round lesion, raising the suspicion of a benign tumor. Other diseases that can develop at the upper lip are calcified lymph node, phlebolith, fibroma, pleomorphic adenoma, myxoma, vascular malformation, salivary gland tumor, non-specific sialadenitis, and malignant tumor. Surgical excision is the favored approach for confirming a diagnosis of intramucosal nodular lesions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SnDODn

Congenital hypothyroidism as a risk factor for central hearing process disorders

Conclusions: The data obtained show a high frequency of lag symptoms in cognitive functions related to central auditory processing, particularly with regard to auditory attention, figure-background ability and auditory memory in patients with congenital hypothyroidism. (Source: Revista Paulista de Pediatria)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GpgLle

A case of minor salivary gland sialolithiasis of the upper lip

Abstract

Background

Sialolithiasis is the most common disease of the salivary glands. Sialolithiasis usually develops in the major salivary glands, and rarely in the minor salivary glands, with only 2% of all cases of sialolithiasis occurring in the minor salivary glands and sublingual glands. Sialoliths in the minor salivary glands result in few or no clinical symptoms and are seldom identified on imaging.

Case presentation

We report herein our experience with a case of minor salivary gland sialolithiasis in a 67-year-old woman. On examination, an elastic soft, mobile, and well-circumscribed mass was palpable within the left upper lip. Ultrasound examination revealed a hypoechoic mass with heterogeneous internal echoes. The mass was excised under local anesthesia. Based on histopathological findings, a diagnosis of minor salivary gland sialolithiasis was established.

Conclusions

Diagnosis of minor salivary gland sialolithiasis is challenging due to the difficulty of detecting sialoliths on imaging. A well-circumscribed mass was detected in the upper lip, and ultrasound examination revealed a round lesion, raising the suspicion of a benign tumor. Other diseases that can develop at the upper lip are calcified lymph node, phlebolith, fibroma, pleomorphic adenoma, myxoma, vascular malformation, salivary gland tumor, non-specific sialadenitis, and malignant tumor. Surgical excision is the favored approach for confirming a diagnosis of intramucosal nodular lesions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SnDODn

Creating an Easier Path for Head/Neck Cancer Patients

Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care. How did I create this pathway? The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—understood the process, what to expect and how to prepare for next steps. After deciding to create this process pathway and getting it approved by the hospital cancer board ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GoFm9E

Creating an Easier Path for Head/Neck Cancer Patients

Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care. How did I create this pathway? The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—understood the process, what to expect and how to prepare for next steps. After deciding to create this process pathway and getting it approved by the hospital cancer board ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GoFm9E

Pediatric immune diseases, all genetics?

NIH Director ' s Wednesday Afternoon Lecture Series Dr. Fischer is interested in understanding how genetic errors cause vulnerability to microorganisms, autoimmunity, inflammation and allergy, with the dual goal to decipher in vivo immunity in humans and to correct its defects.Air date: 2/20/2019 3:00:00 PM (Source: Videocast - All Events)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HQ7jcY

Pediatric immune diseases, all genetics?

NIH Director ' s Wednesday Afternoon Lecture Series Dr. Fischer is interested in understanding how genetic errors cause vulnerability to microorganisms, autoimmunity, inflammation and allergy, with the dual goal to decipher in vivo immunity in humans and to correct its defects.Air date: 2/20/2019 3:00:00 PM (Source: Videocast - All Events)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HQ7jcY

Cochlear implantation as a treatment for single-sided deafness and asymmetric hearing loss: a randomized controlled evaluation of cost-utility

Single-sided deafness (SSD) and asymmetric hearing loss (AHL) have recently been proposed as a new indication for cochlear implantation. There is still no recommended treatment for these hearing deficits, and ... (Source: BMC Ear, Nose and Throat Disorders)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D7jegO

Controlled comparative clinical trial of hearing benefit outcomes for users of the Cochlear ™ Nucleus® 7 Sound Processor with mobile connectivity

. (Source: Cochlear Implants International)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G93ihX

Auditory risk of exposure to ballistic N-waves from bullets

Volume 58, Issue sup1, February 2019, Page S58-S64 . (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DaCHwV

Validation of the Japanese version of the tinnitus functional index (TFI)

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G93fTj

Distorted sound perception and subjective benefit after stapedotomy – a prospective single-centre study

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DdF16j

Envelope frequency following responses are stronger for high-pass than low-pass filtered vowels

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G93ayZ

Online evaluation of congenital amusia (tone deafness) in paediatric stuttering individuals

. (Source: Hearing, Balance and Communication)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D4UxkU

Objective auditory brainstem response classification using machine learning

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GfhFS7

Can adults living with dementia complete pure-tone audiometry? A systematic review

. (Source: International Journal of Audiology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9aK8N

Cochlear implantation as a treatment for single-sided deafness and asymmetric hearing loss: a randomized controlled evaluation of cost-utility

Single-sided deafness (SSD) and asymmetric hearing loss (AHL) have recently been proposed as a new indication for cochlear implantation. There is still no recommended treatment for these hearing deficits, and ... (Source: BMC Ear, Nose and Throat Disorders)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D7jegO

Controlled comparative clinical trial of hearing benefit outcomes for users of the Cochlear ™ Nucleus® 7 Sound Processor with mobile connectivity

. (Source: Cochlear Implants International)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G93ihX

Auditory risk of exposure to ballistic N-waves from bullets

Volume 58, Issue sup1, February 2019, Page S58-S64 . (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DaCHwV

Validation of the Japanese version of the tinnitus functional index (TFI)

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G93fTj

Distorted sound perception and subjective benefit after stapedotomy – a prospective single-centre study

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DdF16j

Envelope frequency following responses are stronger for high-pass than low-pass filtered vowels

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2G93ayZ

Online evaluation of congenital amusia (tone deafness) in paediatric stuttering individuals

. (Source: Hearing, Balance and Communication)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D4UxkU

Objective auditory brainstem response classification using machine learning

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GfhFS7

Can adults living with dementia complete pure-tone audiometry? A systematic review

. (Source: International Journal of Audiology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9aK8N

Regulation of Ectodomain Shedding of ADAM33 In Vitro and In Vivo

TGF- β signaling regulates ectodomain shedding of ADAM33 mainly via an autocatalytic mechanism and is essential for shedding of catalytically-active ADAM33 in vivo. These mechanisms have implications for the genetic contribution of ADAM33 to asthma and BHR. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw47Hi

Cockroach allergens – coping with challenging complexity

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gmr09U

Mining Social Media Data to Assess the Risk of Skin and Soft Tissue Infections from Allergen Immunotherapy

Mining of social media data suggests that skin and soft tissue infection from allergen immunotherapy, prepared with aseptic technique, is as rare as skin and soft tissue infection from Influenza vaccination, a sterile pharmaceutical. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Snyvnp

Reaction thresholds in in peanut-allergic adults and the influence of exercise and sleep deprivation: a randomised controlled trial

Peanut allergy is a public health concern causing severe reactions. Food allergen labeling poorly represents risk, with limited data on thresholds of reactivity and the influence of everyday factors. We estimated peanut threshold doses for a UK peanut-allergic population and examined the effect of sleep deprivation and exercise. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GobYQM

Irradiated Almond Flour Meets Established Criteria for use in Oral Immunotherapy

Almond, a popular tree nut, can cause IgE-mediated allergic reactions. Almond flour from various vendors are often contaminated with high levels of microbes. Irradiation is a method that can decrease bioburden, however, irradiated almond flour used in oral immunotherapy (OIT) trials has not been characterized. We aimed to quantify relative amounts of the major almond allergen (Pru du 6) and bioburden levels present in irradiated almond flour used in OIT trials and assess whether these parameters are stable. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqYdHp

Effect of House Dust Mite SLIT-tablet Treatment on Quality of Sleep in Allergic Rhinitis Patients

House dust mite (HDM) SLIT-tablet (12 SQ-HDM, ALK, Denmark) has been shown to be effective in treating HDM allergic rhinitis and asthma in DBPC trials. This post-hoc analysis investigates effect of treatment with SQ-HDM SLIT-tablet on sleep in HDM allergic rhinitis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gmpuo9

Sex Differences in Type 2 Innate Lymphoid Cells in Adult Asthmatics

Cellular sex differences remain largely unexplored in asthma. Type 2 innate lymphoid cells (ILC2s), identified as critical modulators of asthmatic inflammation, are less abundant in the lungs of HDM-sensitized and challenged male mice. Specifically, lung ILC2s numbers increase in the absence of androgen signaling, but not estrogen. Therefore, we hypothesize that female asthmatics have increased airway ILC2s compared to males. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsOD6Z

Risk Factors for Anaphylaxis in Patients with Cutaneous and Systemic Mastocytosis

We examined factors associated with anaphylaxis in these two populations. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GqajKz

Topical Application of the Quaternary Ammonium Compound Didecyldimethylammonium Chloride Activates Type 2 Innate Lymphoid Cells and Initiates a Mixed-type Allergic Response

Didecyldimethylammonium chloride (DDAC) is an antimicrobial dialkyl-quaternary ammonium compound used in numerous products. Clinical data suggest that DDAC exposure elicits multiple types of hypersensitivity reactions; animal data supports a mixed-type response. Skin is a major route of exposure to chemicals; thus, we investigated immune responses in the skin to determine the mechanism behind DDAC-induced sensitization. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqYMkz

Association of Prescription Opioid Use for Chronic Pain Syndromes with Asthma and Allergy

Opioids have, in addition to analgesic properties, immune altering effects including upregulation of Th2 responses. Whether this has clinical expression in altering asthma and allergic responses has not been determined. We hypothesize that in patients with chronic pain conditions, there is an increased prevalence of asthma and allergy when prescribed opioid medications. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GmplB7

TNF Induces the Production of Type 2 Cytokines in Human Group 2 Innate Lymphoid Cells

Group 2 innate lymphoid cells (ILC2s) play an important role in the initiation and amplification of type 2 inflammation by producing type 2 cytokines, including IL-5 and IL-13, and are elevated in type 2 inflammatory diseases. Recently, several studies, including our own, found that members of the TNF superfamily, TL1A and RANKL, induced production of type 2 cytokines in ILC2s. However, whether TNF itself induces type 2 cytokines in ILC2s has not been elucidated. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Snv4x3

Is Emergency Room Care After Home Use Of An Epinephrine Auto Injector Always Needed?

Emergency room evaluation and observation of patients who have used an epinephrine auto injector to treat an allergic food reaction at home is the standard of care. Requiring patients to go to the ER after epinephrine injection often deters families from administering epinephrine. Withholding or delaying treatment with epinephrine increases the risk of death from anaphylaxis. We hypothesized that this standard could be modified to prompt the early and more frequent use of epinephrine during an allergic reaction without decreasing patient safety. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GnZyIL

Unconventional ST2- and CD127-negative lung ILC2 populations are induced by Alternaria

The purpose of this study was to determine whether conventionally used ILC2 markers, ST2 and CD127, are sufficient to include all Th2-cytokine producing ILCs. We hypothesized that ST2- and CD127-negative ILC2 populations exist in mouse lung and that these non-traditional populations might be activated by the clinically relevant fungal allergen Alternaria, a known potent inducer of IL-33. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Su3m1E

Eosinophils Display Subtype-specific Metabolic Profiles

Under homeostatic conditions and in disease progression eosinophils have a variety of effector functions regulating Local Immunity And/or Remodeling/Repair (LIAR hypothesis). These activities are manifestations of different eosinophil subtypes, which, in turn, depend on the cytokine milieu of the tissue microenvironment. Eosinophil subtypes are characterized by expression of specific genes and we hypothesize that their functions are supported by a distinct metabolic phenotype. The goal of this study was to examine relationships between Th1 or Th2 cytokine-dependent gene expression and parameters of energy metabolism in mouse eosinophils. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GmpaFX

Estrogen receptor alpha signaling increases ILC2-mediated allergic airway inflammation

Sex hormones regulate asthma pathogenesis, providing a potential mechanism for female predominance in adult asthma. Group 2 innate lymphoid cells (ILC2) produce IL-5 and IL-13, enhancing allergic airway inflammation. While testosterone attenuated ILC2-mediated airway inflammation, the role of estrogen receptor (ER) signaling is unknown. We hypothesized that ER α signaling increases ILC2-mediated airway inflammation. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SvkoMI

Usability of a Novel Digital Asthma Management Program

Digital asthma management programs can enable closer monitoring and improved asthma management in the home environment. The Tueo program involves non-contact physiologic monitors, personalized analytics, and a smartphone application (app) to deliver targeted educational and clinical feedback that promotes asthma self-management. Whether the caregivers of asthmatic children find the app easy to use and access remains unknown. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GnZo47

Integrative Analysis of the Intestinal Metabolome of Childhood Asthma

The intestinal metabolome reflects biological consequences of diverse exposures and may provide insight into asthma pathophysiology. We performed an untargeted integrative analysis of the intestinal metabolome of childhood asthma in this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial (VDAART). (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqYLNx

Prostaglandin I2 signaling promotes Treg function during allergic inflammation

Our laboratory reported that prostaglandin I2 (PGI2) promotes immune tolerance in mice. Thus, we hypothesized that PGI2 promotes the functionality of Tregs in vivo, in an adoptive-transfer model of allergic inflammation. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GnZhWf

Characterization of Gut Microbiome in Infants with Severe Respiratory Syncytial Virus Bronchiolitis

The effects of early life exposures, including respiratory syncytial virus (RSV) infection, on the infant gut microbiome may contribute to immune dysregulation and the development of asthma. Here, we describe the gut microbiome in infants during severe RSV bronchiolitis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Svkowc

Influence of Hydrophobic Cargo Binding on the Structure, Stability, and Allergenicity of the Cockroach Allergen Bla g 1

The rate of endosomal processing of allergens by antigen presenting cells has been suggested to influence sensitization. In addition, allergens often occur in the presence of lipids and other hydrophobic ligands, which also influence allergenicity. Due to its ability to bind a variety of hydrophobic cargoes, the cockroach allergen Bla g 1 was used as a model system to probe for a potential connection between antigen processing and lipid delivery, and the molecular mechanisms underlying this interaction. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gon48l

Regulation of Ectodomain Shedding of ADAM33 In Vitro and In Vivo

TGF- β signaling regulates ectodomain shedding of ADAM33 mainly via an autocatalytic mechanism and is essential for shedding of catalytically-active ADAM33 in vivo. These mechanisms have implications for the genetic contribution of ADAM33 to asthma and BHR. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sw47Hi

Cockroach allergens – coping with challenging complexity

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gmr09U

Mining Social Media Data to Assess the Risk of Skin and Soft Tissue Infections from Allergen Immunotherapy

Mining of social media data suggests that skin and soft tissue infection from allergen immunotherapy, prepared with aseptic technique, is as rare as skin and soft tissue infection from Influenza vaccination, a sterile pharmaceutical. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Snyvnp

Reaction thresholds in in peanut-allergic adults and the influence of exercise and sleep deprivation: a randomised controlled trial

Peanut allergy is a public health concern causing severe reactions. Food allergen labeling poorly represents risk, with limited data on thresholds of reactivity and the influence of everyday factors. We estimated peanut threshold doses for a UK peanut-allergic population and examined the effect of sleep deprivation and exercise. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GobYQM

Irradiated Almond Flour Meets Established Criteria for use in Oral Immunotherapy

Almond, a popular tree nut, can cause IgE-mediated allergic reactions. Almond flour from various vendors are often contaminated with high levels of microbes. Irradiation is a method that can decrease bioburden, however, irradiated almond flour used in oral immunotherapy (OIT) trials has not been characterized. We aimed to quantify relative amounts of the major almond allergen (Pru du 6) and bioburden levels present in irradiated almond flour used in OIT trials and assess whether these parameters are stable. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqYdHp

Effect of House Dust Mite SLIT-tablet Treatment on Quality of Sleep in Allergic Rhinitis Patients

House dust mite (HDM) SLIT-tablet (12 SQ-HDM, ALK, Denmark) has been shown to be effective in treating HDM allergic rhinitis and asthma in DBPC trials. This post-hoc analysis investigates effect of treatment with SQ-HDM SLIT-tablet on sleep in HDM allergic rhinitis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gmpuo9

Sex Differences in Type 2 Innate Lymphoid Cells in Adult Asthmatics

Cellular sex differences remain largely unexplored in asthma. Type 2 innate lymphoid cells (ILC2s), identified as critical modulators of asthmatic inflammation, are less abundant in the lungs of HDM-sensitized and challenged male mice. Specifically, lung ILC2s numbers increase in the absence of androgen signaling, but not estrogen. Therefore, we hypothesize that female asthmatics have increased airway ILC2s compared to males. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsOD6Z

Risk Factors for Anaphylaxis in Patients with Cutaneous and Systemic Mastocytosis

We examined factors associated with anaphylaxis in these two populations. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GqajKz

Topical Application of the Quaternary Ammonium Compound Didecyldimethylammonium Chloride Activates Type 2 Innate Lymphoid Cells and Initiates a Mixed-type Allergic Response

Didecyldimethylammonium chloride (DDAC) is an antimicrobial dialkyl-quaternary ammonium compound used in numerous products. Clinical data suggest that DDAC exposure elicits multiple types of hypersensitivity reactions; animal data supports a mixed-type response. Skin is a major route of exposure to chemicals; thus, we investigated immune responses in the skin to determine the mechanism behind DDAC-induced sensitization. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqYMkz

Association of Prescription Opioid Use for Chronic Pain Syndromes with Asthma and Allergy

Opioids have, in addition to analgesic properties, immune altering effects including upregulation of Th2 responses. Whether this has clinical expression in altering asthma and allergic responses has not been determined. We hypothesize that in patients with chronic pain conditions, there is an increased prevalence of asthma and allergy when prescribed opioid medications. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GmplB7

TNF Induces the Production of Type 2 Cytokines in Human Group 2 Innate Lymphoid Cells

Group 2 innate lymphoid cells (ILC2s) play an important role in the initiation and amplification of type 2 inflammation by producing type 2 cytokines, including IL-5 and IL-13, and are elevated in type 2 inflammatory diseases. Recently, several studies, including our own, found that members of the TNF superfamily, TL1A and RANKL, induced production of type 2 cytokines in ILC2s. However, whether TNF itself induces type 2 cytokines in ILC2s has not been elucidated. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Snv4x3

Is Emergency Room Care After Home Use Of An Epinephrine Auto Injector Always Needed?

Emergency room evaluation and observation of patients who have used an epinephrine auto injector to treat an allergic food reaction at home is the standard of care. Requiring patients to go to the ER after epinephrine injection often deters families from administering epinephrine. Withholding or delaying treatment with epinephrine increases the risk of death from anaphylaxis. We hypothesized that this standard could be modified to prompt the early and more frequent use of epinephrine during an allergic reaction without decreasing patient safety. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GnZyIL

Unconventional ST2- and CD127-negative lung ILC2 populations are induced by Alternaria

The purpose of this study was to determine whether conventionally used ILC2 markers, ST2 and CD127, are sufficient to include all Th2-cytokine producing ILCs. We hypothesized that ST2- and CD127-negative ILC2 populations exist in mouse lung and that these non-traditional populations might be activated by the clinically relevant fungal allergen Alternaria, a known potent inducer of IL-33. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Su3m1E

Eosinophils Display Subtype-specific Metabolic Profiles

Under homeostatic conditions and in disease progression eosinophils have a variety of effector functions regulating Local Immunity And/or Remodeling/Repair (LIAR hypothesis). These activities are manifestations of different eosinophil subtypes, which, in turn, depend on the cytokine milieu of the tissue microenvironment. Eosinophil subtypes are characterized by expression of specific genes and we hypothesize that their functions are supported by a distinct metabolic phenotype. The goal of this study was to examine relationships between Th1 or Th2 cytokine-dependent gene expression and parameters of energy metabolism in mouse eosinophils. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GmpaFX

Estrogen receptor alpha signaling increases ILC2-mediated allergic airway inflammation

Sex hormones regulate asthma pathogenesis, providing a potential mechanism for female predominance in adult asthma. Group 2 innate lymphoid cells (ILC2) produce IL-5 and IL-13, enhancing allergic airway inflammation. While testosterone attenuated ILC2-mediated airway inflammation, the role of estrogen receptor (ER) signaling is unknown. We hypothesized that ER α signaling increases ILC2-mediated airway inflammation. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SvkoMI

Usability of a Novel Digital Asthma Management Program

Digital asthma management programs can enable closer monitoring and improved asthma management in the home environment. The Tueo program involves non-contact physiologic monitors, personalized analytics, and a smartphone application (app) to deliver targeted educational and clinical feedback that promotes asthma self-management. Whether the caregivers of asthmatic children find the app easy to use and access remains unknown. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GnZo47

Integrative Analysis of the Intestinal Metabolome of Childhood Asthma

The intestinal metabolome reflects biological consequences of diverse exposures and may provide insight into asthma pathophysiology. We performed an untargeted integrative analysis of the intestinal metabolome of childhood asthma in this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial (VDAART). (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqYLNx

Prostaglandin I2 signaling promotes Treg function during allergic inflammation

Our laboratory reported that prostaglandin I2 (PGI2) promotes immune tolerance in mice. Thus, we hypothesized that PGI2 promotes the functionality of Tregs in vivo, in an adoptive-transfer model of allergic inflammation. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GnZhWf

Characterization of Gut Microbiome in Infants with Severe Respiratory Syncytial Virus Bronchiolitis

The effects of early life exposures, including respiratory syncytial virus (RSV) infection, on the infant gut microbiome may contribute to immune dysregulation and the development of asthma. Here, we describe the gut microbiome in infants during severe RSV bronchiolitis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Svkowc

Influence of Hydrophobic Cargo Binding on the Structure, Stability, and Allergenicity of the Cockroach Allergen Bla g 1

The rate of endosomal processing of allergens by antigen presenting cells has been suggested to influence sensitization. In addition, allergens often occur in the presence of lipids and other hydrophobic ligands, which also influence allergenicity. Due to its ability to bind a variety of hydrophobic cargoes, the cockroach allergen Bla g 1 was used as a model system to probe for a potential connection between antigen processing and lipid delivery, and the molecular mechanisms underlying this interaction. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gon48l

Genome structure of malaria parasites linked to virulence

(University of California - Riverside) An international research team led by scientists at the University of California, Riverside, and the La Jolla Institute for Immunology has found that malaria parasite genomes are shaped by parasite-specific gene families, and that this genome organization strongly correlates with the parasite's virulence. The findings highlight the importance of spatial genome organization in gene regulation and the control of virulence in malaria parasites. (Source: EurekAlert! - Infectious and Emerging Diseases)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UEmR4T

Teva's Generic EpiPen Launch Stalls Months After Approval Teva's Generic EpiPen Launch Stalls Months After Approval

Many of the largest U.S. pharmacies and drug distributors do not have Teva Pharmaceutical Industries Ltd's generic version of the life-saving EpiPen allergy treatment five months after it was approved for sale in the United States, pharmacy chains and a group that tracks drug shortages told Reuters.Reuters Health Information (Source: Medscape Medical News Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UxMrbQ

Genome structure of malaria parasites linked to virulence

(University of California - Riverside) An international research team led by scientists at the University of California, Riverside, and the La Jolla Institute for Immunology has found that malaria parasite genomes are shaped by parasite-specific gene families, and that this genome organization strongly correlates with the parasite's virulence. The findings highlight the importance of spatial genome organization in gene regulation and the control of virulence in malaria parasites. (Source: EurekAlert! - Infectious and Emerging Diseases)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UEmR4T

Teva's Generic EpiPen Launch Stalls Months After Approval Teva's Generic EpiPen Launch Stalls Months After Approval

Many of the largest U.S. pharmacies and drug distributors do not have Teva Pharmaceutical Industries Ltd's generic version of the life-saving EpiPen allergy treatment five months after it was approved for sale in the United States, pharmacy chains and a group that tracks drug shortages told Reuters.Reuters Health Information (Source: Medscape Medical News Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UxMrbQ

Google unveils two new apps support communication for deaf and hard of hearing people

One app will help transcribe speech to text and the other will help amplify certain sounds and minimize others.   (Source: mobihealthnews)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SbRj9S

40 Cases of Measles Confirmed Amid Concerns the Pacific Northwest Outbreak May Spread

(VANCOUVER, Wash.) — A measles outbreak in the Pacific Northwest became more worrisome Wednesday with word that people infected with the extremely contagious viral illness traveled to Hawaii and central Oregon after being exposed. The revelation prompted public health officials in Oregon's Deschutes County and in Hawaii to issue alerts, although no cases were confirmed in either location. "It raises concerns that this can go on for a long time, become geographically larger than it is and more cases over weeks and months," said Dr. Alan Melnick, public health director for Clark County, in southern Washington, which is at the epicenter of the outbreak and has a lower-than-normal vaccination rate. There are 40 confirmed cases in the Northwest, including 38 clustered i...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UvxFSH

Google unveils two new apps support communication for deaf and hard of hearing people

One app will help transcribe speech to text and the other will help amplify certain sounds and minimize others.   (Source: mobihealthnews)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SbRj9S

40 Cases of Measles Confirmed Amid Concerns the Pacific Northwest Outbreak May Spread

(VANCOUVER, Wash.) — A measles outbreak in the Pacific Northwest became more worrisome Wednesday with word that people infected with the extremely contagious viral illness traveled to Hawaii and central Oregon after being exposed. The revelation prompted public health officials in Oregon's Deschutes County and in Hawaii to issue alerts, although no cases were confirmed in either location. "It raises concerns that this can go on for a long time, become geographically larger than it is and more cases over weeks and months," said Dr. Alan Melnick, public health director for Clark County, in southern Washington, which is at the epicenter of the outbreak and has a lower-than-normal vaccination rate. There are 40 confirmed cases in the Northwest, including 38 clustered i...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UvxFSH

Buccal nerve dissection via an intraoral approach: correcting an error regarding buccal nerve blockade

The buccal nerve (BN) supplies sensation to the skin over the anterior part of the buccinator and the buccal mucosa, as well as the buccal gingivae corresponding to the second and third molar teeth. Some dental anatomy books show the main trunk of the BN coursing over the buccal shelf of the mandible, which leads to a significant misunderstanding of this anatomy. Therefore, this study aims to reveal the course of the BN on the retromolar area and establish new evidence based anatomy for appropriate buccal nerve blockade.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BuyNPN

Physical Simulation Models in Oral and Maxillofacial Surgery: A New Concept in 3-Dimensional Modeling for Removal of Impacted Third Molars

A medical grade computed tomographic (CT) scan of a mandible was obtained. A DICOM series was exported in 1mm slices and digitally 3D reconstructed to create a stereolithography file (STL). The mandible STL was digitally manipulated to create sites for simulated placement of third molar teeth, then 3D printed in a plastic material. Third molar tooth models were coated in red box wax, simulating a ligament space, then submerged into the mandible site using lab stone. A layer of GI mask was placed over the impacted third molar site for soft tissue simulation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bj2naS

Autogenous Mandibular Bone Graft for Maxillary LeFort I Osteotomy Inter-positional Gap in Orthognathic Surgery: A Technique Case Series

Correction of maxillofacial skeletal dental deformities often includes surgical interventions in the maxilla and mandible. LeFort I maxillary osteotomies are performed to correct maxillary horizontal, vertical and transverse discrepancies. Repositioning of the maxilla creates an inter-positional gap in bone which may lead to psuedoarthrosis, instability, mobility, infection and eventual relapse. Grafting the inter-positional gap with bone creates mechanical stops to prevent relapse, provides a matrix for secondary ossification, accelerates bony union and inhibits soft tissue herniation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tw5zGZ

Buccal nerve dissection via an intraoral approach: correcting an error regarding buccal nerve blockade

The buccal nerve (BN) supplies sensation to the skin over the anterior part of the buccinator and the buccal mucosa, as well as the buccal gingivae corresponding to the second and third molar teeth. Some dental anatomy books show the main trunk of the BN coursing over the buccal shelf of the mandible, which leads to a significant misunderstanding of this anatomy. Therefore, this study aims to reveal the course of the BN on the retromolar area and establish new evidence based anatomy for appropriate buccal nerve blockade.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BuyNPN

Physical Simulation Models in Oral and Maxillofacial Surgery: A New Concept in 3-Dimensional Modeling for Removal of Impacted Third Molars

A medical grade computed tomographic (CT) scan of a mandible was obtained. A DICOM series was exported in 1mm slices and digitally 3D reconstructed to create a stereolithography file (STL). The mandible STL was digitally manipulated to create sites for simulated placement of third molar teeth, then 3D printed in a plastic material. Third molar tooth models were coated in red box wax, simulating a ligament space, then submerged into the mandible site using lab stone. A layer of GI mask was placed over the impacted third molar site for soft tissue simulation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bj2naS

Autogenous Mandibular Bone Graft for Maxillary LeFort I Osteotomy Inter-positional Gap in Orthognathic Surgery: A Technique Case Series

Correction of maxillofacial skeletal dental deformities often includes surgical interventions in the maxilla and mandible. LeFort I maxillary osteotomies are performed to correct maxillary horizontal, vertical and transverse discrepancies. Repositioning of the maxilla creates an inter-positional gap in bone which may lead to psuedoarthrosis, instability, mobility, infection and eventual relapse. Grafting the inter-positional gap with bone creates mechanical stops to prevent relapse, provides a matrix for secondary ossification, accelerates bony union and inhibits soft tissue herniation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tw5zGZ

Physical Simulation Models in Oral and Maxillofacial Surgery: A New Concept in 3-Dimensional Modeling for Removal of Impacted Third Molars

A medical grade computed tomographic (CT) scan of a mandible was obtained. A DICOM series was exported in 1mm slices and digitally 3D reconstructed to create a stereolithography file (STL). The mandible STL was digitally manipulated to create sites for simulated placement of third molar teeth, then 3D printed in a plastic material. Third molar tooth models were coated in red box wax, simulating a ligament space, then submerged into the mandible site using lab stone. A layer of GI mask was placed over the impacted third molar site for soft tissue simulation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bj2naS

Autogenous Mandibular Bone Graft for Maxillary LeFort I Osteotomy Inter-positional Gap in Orthognathic Surgery: A Technique Case Series

Correction of maxillofacial skeletal dental deformities often includes surgical interventions in the maxilla and mandible. LeFort I maxillary osteotomies are performed to correct maxillary horizontal, vertical and transverse discrepancies. Repositioning of the maxilla creates an inter-positional gap in bone which may lead to psuedoarthrosis, instability, mobility, infection and eventual relapse. Grafting the inter-positional gap with bone creates mechanical stops to prevent relapse, provides a matrix for secondary ossification, accelerates bony union and inhibits soft tissue herniation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tw5zGZ

Buccal nerve dissection via an intraoral approach: correcting an error regarding buccal nerve blockade

The buccal nerve (BN) supplies sensation to the skin over the anterior part of the buccinator and the buccal mucosa, as well as the buccal gingivae corresponding to the second and third molar teeth. Some dental anatomy books show the main trunk of the BN coursing over the buccal shelf of the mandible, which leads to a significant misunderstanding of this anatomy. Therefore, this study aims to reveal the course of the BN on the retromolar area and establish new evidence based anatomy for appropriate buccal nerve blockade.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BuyNPN

Physical Simulation Models in Oral and Maxillofacial Surgery: A New Concept in 3-Dimensional Modeling for Removal of Impacted Third Molars

A medical grade computed tomographic (CT) scan of a mandible was obtained. A DICOM series was exported in 1mm slices and digitally 3D reconstructed to create a stereolithography file (STL). The mandible STL was digitally manipulated to create sites for simulated placement of third molar teeth, then 3D printed in a plastic material. Third molar tooth models were coated in red box wax, simulating a ligament space, then submerged into the mandible site using lab stone. A layer of GI mask was placed over the impacted third molar site for soft tissue simulation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bj2naS