Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,

Κυριακή 10 Φεβρουαρίου 2019

Allergic contact dermatitis to (meth)acrylates involving nail technicians and users: prognosis and differential diagnosis

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Allergic contact dermatitis to (meth)acrylates involving nail technicians and users: prognosis and differential diagnosis

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Combination Therapy With VRC-HIVMAB060-00-AB (VRC01) and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions

Condition: HIV Interventions: Biological: VRC-HIVMAB060-00-AB (VRC01); Biological: 10-1074; Biological: Normal Saline Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers

Condition: Opioid Addiction Interventions: Drug: MDZ; Drug: ANS-6637 Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Retrospective Chart Review of Candida Fungemia

Condition: Candida Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)

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Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet

Conditions: Intervention; Food Allergy; Food Preferences; Food Intolerance; Diet Habit; Diet Modification Intervention: Behavioral: Multicomponent intervention Sponsors: University Rovira i Virgili; Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)

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Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Conditions: Pulmonary Invasive Mold Infections; Pulmonary Invasive Aspergillosis Intervention: Diagnostic Test: Non-Invasive Testing for PIMI Sponsors: Duke University; Children's Hospital of Philadelphia; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Allergy UK Research and Development Nurse Project

Condition: Allergy Intervention: Other: Nurse Led Allergy Clinic Sponsors: University of Edinburgh; Allergy UK Recruiting (Source: ClinicalTrials.gov)

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Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population

Conditions: Hepatitis E; Immunisation Interventions: Biological: HEV 239; Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Combination Therapy With VRC-HIVMAB060-00-AB (VRC01) and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions

The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers

Retrospective Chart Review of Candida Fungemia

Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet

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Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Allergy UK Research and Development Nurse Project

Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population

T2 mapping with 3.0 T MRI of the temporomandibular joint disc of patients with disc dislocation

Publication date: Available online 10 February 2019

Source: Magnetic Resonance Imaging

Author(s): Margit Bristela, Astrid Skolka, Jaryna Eder, Pavol Szomolanyi, Michael Weber, Eva Piehslinger, Martina Schmid-Schwap, Siegfried Trattnig

Abstract

Introduction

T2 mapping, as a quantitative biochemical MRI-technique that provides information on water and collagen fiber content and composition, was shown to be clinically feasible for the evaluation of healthy temporomandibular joints.

Objectives

The aim of our study was to compare the T2 values of whole discs in patients with and without disc dislocation, to evaluate the possible influence of morphological findings on T2 values and to assess the interrater agreement.

Methods

Sixty-six patients were included in the study. Three experienced examiners assessed the perceptibility of the morphological parameters and the position of the articular disc on the morphological MR images. On the T2 maps, the T2 values of the region-of-interest (ROI) were assessed.

Results

The ICC (Intraclass Correlation Coefficient) for the reproducibility of the T2 values was 0.717. The assessment of the morphologic parameters was excellent or good in most of the discs. There was no significant difference in the T2 values based on disc position or signal intensity. But, a statistically significant moderation effect (p = .014) could be identified, indicating that the effect of disc position differs for different signal intensities. Condyle position, effusion, and degenerative changes showed pronounced moderation effects on the T2 values.

Conclusion

Due to the high sensitivity to effusion, T2 mapping currently seems to be unsuitable as a diagnostic tool for routine use in the temporomandibular joint. The moderation effect clearly shows the influence of factors such as signal intensity, effusion, arthrosis, and condyle position. Perhaps a solution for these problems could be the development of dedicated TMJ coils for higher field strengths at 7.0 T.

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T2 mapping with 3.0 T MRI of the temporomandibular joint disc of patients with disc dislocation

Publication date: Available online 10 February 2019

Source: Magnetic Resonance Imaging

Author(s): Margit Bristela, Astrid Skolka, Jaryna Eder, Pavol Szomolanyi, Michael Weber, Eva Piehslinger, Martina Schmid-Schwap, Siegfried Trattnig

Abstract

Introduction

Objectives

Methods

Results

Conclusion

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Guidelines for best practice: Imaging for Age Estimation in the Living

Publication date: Available online 10 February 2019

Source: Journal of Forensic Radiology and Imaging

Author(s): Edel Doyle, Nicholas Márquez-Grant, Lisa Field, Trish Holmes, Owen J Arthurs, Rick R. van Rijn, Lucina Hackman, Kathleen Kasper, Jim Lewis, Peter Loomis, Denise Elliott, Jeroen Kroll, Mark Viner, Soren Blau, Alison Brough, Stella Martín de las Heras, Pedro Manuel Garamendi

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Guidelines for best practice: Imaging for Age Estimation in the Living

Publication date: Available online 10 February 2019

Source: Journal of Forensic Radiology and Imaging

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The importance of BRAF‐V600E mutation to ameloblastoma metabolism

Abstract

Background

Ameloblastoma is a locally infiltrative, aggressive epithelial odontogenic neoplasm. BRAF‐V600E mutation is frequently found in this tumor and has a pivotal role in its pathogenesis, but the consequences of this alteration need to be addressed. An untargeted metabolomics approach was applied to verify whether metabolic disturbances are related to tumor biology and whether BRAF‐V600E mutation contributes to these alterations.

Methods

Formalin‐fixed and paraffin‐embedded tissue specimens from thirteen ameloblastoma and six dental follicles were included in this study. BRAF mutational status was determined by competitive allele‐specific real‐time PCR. Metabolite extracts were analyzed using gas chromatography coupled to mass spectrometry. Univariate and multivariate statistical methods were employed to compare the metabolic profiles of the samples.

Results

The abundance of eleven metabolites were significantly higher in ameloblastoma in relation to dental follicles, including amino acids, fatty acids, carbohydrates, inorganic acids, and organoheterocyclic compounds. The presence of BRAF‐V600E mutations in ameloblastoma was related to decreased levels of glycerol in comparison to tumors carrying only wild‐type alleles of this gene. No metabolic differences were observed between recurrent and primary manifestations of ameloblastoma.

Conclusions

Ameloblastoma exhibits a distinct metabolic profile from normal odontogenic epithelium. BRAF‐V600E may contribute to metabolic alterations in ameloblastoma. Collectively, our findings suggest that metabolic alterations might play a role in tumor pathogenesis.

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Association between geographic tongue and psoriasis. A systematic review and meta‐analyses

Abstract

Geographic tongue (GT) has been described as a predictor of psoriasis. The objective of this study was to analyse the prevalence of GT in psoriatic and non‐psoriatic patients. For this purpose, we conducted a systematic review and meta‐analysis. A literature search was performed on PubMed, Embase, Web of Science and the Cochrane Database of Systematic Reviews. The search and selection process was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) criteria. Only case‐control studies were selected and the prevalence of GT in both groups was compared. Eleven articles met the inclusion criteria and the frequency of GT was statistically associated with psoriasis in ten studies. The pooled odds ratio (OR) was 3.53 (95% confidence interval [CI] 2.56–4.86). There were no significant differences between the presence of GT and the clinical form. However, the Psoriasis Area and Severity Index (PASI) score was statistically higher in patients affected by GT in three of four studies. Psoriatic patients with GT also exhibited less improvement in the PASI score after treatment. One study found an association between GT and a negative impact on patients' quality of life. Nevertheless, age, gender, toxic habits, psoriasis onset and duration of the disease were not clearly associated. The results support the concept of GT as a manifestation of psoriasis. Future research should focus on the repercussions of GT in psoriatic patients, due to the negative consequences on severity and treatment response.

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The importance of BRAF‐V600E mutation to ameloblastoma metabolism

Abstract

Background

Methods

Results

Conclusions

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Association between geographic tongue and psoriasis. A systematic review and meta‐analyses

Abstract

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Juvenile nasopharyngeal angiofibroma: A retrospective study of 27 cases in the ent Department of ipo‐Porto

Abstract

Juvenile nasopharyngeal angiofibroma (JNA) is a benign, rare and highly vascular tumour, occurring in adolescent males.

Clinical records of 27 patients who underwent surgical resection, performed between 1989 and 2017, were reviewed.

Three patients were submitted to paralatero‐nasal rhinotomy, 23 patients (85%), to the sublabial transnasomaxillary approach (Rouge Denker approach), complemented in 19 (70.0%) with transpalatine approach (Wilson technique). Endoscopic resection was performed only at one patient stage IB.

There were no cases of death, major significant complications or significant morbidity. Persistence rate was 18.5% and recurrence rate 14.8%.

Patients with tumour extension to infratemporal fossa and no massive cavernous sinus invasion may be treated effectively without previous embolization and facial scars, with sublabial transnasomaxillary approach (Rouge Denker approach), complemented with transpalatine approach (Wilson technique).

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Juvenile nasopharyngeal angiofibroma: A retrospective study of 27 cases in the ent Department of ipo‐Porto

Abstract

Juvenile nasopharyngeal angiofibroma (JNA) is a benign, rare and highly vascular tumour, occurring in adolescent males.

Clinical records of 27 patients who underwent surgical resection, performed between 1989 and 2017, were reviewed.

There were no cases of death, major significant complications or significant morbidity. Persistence rate was 18.5% and recurrence rate 14.8%.

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The Effects of Ozone Therapy on Periodontal Therapy: A Randomized Placebo‐Controlled Clinical Trial

Abstract

Objectives

The aim of this randomized split‐mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non‐surgical periodontal therapy.

Methods

A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm CAL were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non‐surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin‐3 (PTX‐3), interleukin‐1β (IL‐1β) and high sensitivity C‐reactive protein (Hs‐CRP) were evaluated. All statistical data were analyzed using SPSS software.

Results

Total of 36 participants completed the study (18 males, 18 females). PI, GI, PD, percentage of bleeding on probing, percentage of pockets deeper than 5mm and CAL, and percentage of ≥3 mm CAL, were improved, and there were no significant differences between the two sides. All inflammatory parameters, PTX‐3, Hs‐CRP and IL‐1β, were reduced at 3‐months follow‐up. Only the decrease in PTX‐3 levels between baseline and 3‐months follow‐up was statistically significant.

Conclusions

Ozone therapy did not have any additional effect on periodontal parameters. All cytokines were reduced after periodontal therapy. Only PTX‐3 levels were significantly lower at ozone sites compared to those at the control sites.

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Sex Hormone Replacement Therapy in Periodontology – A Systematic Review

Abstract

Objective

To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans.

Materials and Methods

Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/Medline. Human observational and interventional studies that evaluated the following parameters were included: Clinical Attachment Loss (CAL), Probing Pocket Depth (PPD), Bleeding on Probing (BOP), Radiographic Bone Loss (RBL) or osseointegration.

Results

Initial search retrieved 1282 non‐duplicated articles. Fifteen studies were selected after inclusion criteria were applied. All studies were performed in postmenopausal women. Mean differences for PPD reduction ranged from 0.02‐0.2 mm in HRT‐positive patients; mean CAL gain ‐0.18‐0.54 mm; mean RBL reduction ‐0.87‐0.15 mm; and mean BOP reduction 9‐30.3%. Failure rate of dental implants increased ‐5.5‐11.21% when HRT was used.

Conclusions

Very low but consistent evidence suggests a reduction in BOP and no impact on RBL in postmenopausal women receiving HRT. There are inconsistent reports that suggests that HRT in postmenopausal women: 1)improves or does not impact PPD reduction and CAL gain; and 2)does not impact or increase implant loss. In summary, there is no evidence to support HRT prescription for either men or women for periodontal/implant placement purposes.

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The Effects of Ozone Therapy on Periodontal Therapy: A Randomized Placebo‐Controlled Clinical Trial

Abstract

Objectives

Methods

Results

Conclusions

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Sex Hormone Replacement Therapy in Periodontology – A Systematic Review

Abstract

Objective

To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans.

Materials and Methods

Results

Conclusions

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Σάββατο 9 Φεβρουαρίου 2019

The Bare Necessities: Uncovering Essential and Condition‐Critical Genes with Transposon Sequencing

Summary

Querying gene function in bacteria has been greatly accelerated by the advent of transposon sequencing (Tn‐seq) technologies (related Tn‐seq strategies are known as TraDIS, INSeq, RB‐TnSeq and HITS). Pooled populations of transposon mutants are cultured in an environment and next‐generation sequencing tools are used to determine areas of the genome that are important for bacterial fitness. In this review we provide an overview of Tn‐seq methodologies and discuss how Tn‐seq has been applied, or could be applied, to the study of oral microbiology. These applications include studying the essential genome as a means to rationally design therapeutic agents. Tn‐seq has also contributed to our understanding of well‐studied biological processes in oral bacteria. Other important applications include in vivo pathogenesis studies and use of Tn‐seq to probe the molecular basis of microbial interactions. We also highlight recent advancements in techniques that act in synergy with Tn‐seq such as CRISPR interference and microfluidic chip platforms.

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The Bare Necessities: Uncovering Essential and Condition‐Critical Genes with Transposon Sequencing

Summary

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K-Means Clustering Optimizing Deep Stacked Sparse Autoencoder

Abstract

Because of the large structure and long training time, the development cycle of the common depth model is prolonged. How to speed up training is a problem deserving of study. In order to accelerate training, K-means clustering optimizing deep stacked sparse autoencoder (K-means sparse SAE) is presented in this paper. First, the input features are divided into K small subsets by K-means clustering, then each subset is input into corresponding autoencoder model for training, which only has fewer nodes in the hidden layer than traditional models. After training, each autoencoder's trained weights and biases is merged to obtain the next layer's input features by feedforward network. The above steps are repeated till the softmax layer, then fine-tuning is carried out. Using MNIST-Rotation datasets to train the network that has three hidden layers and each layer has 800 nodes, the improved model has higher classification accuracy and shorter training time when K = 10. With K increasing, the training time is reduced to almost the same as the fine-tuning time but the recognition ability is descended. Compared with the recently stacked denoising sparse autoencoder, the recognition accuracy is improved by 1%, not only the noise factor is not selected but also the training speed is significantly increased. The trained filters from the improved model is also used to train convolutional autoencoder, and it performs better than traditional models. We find that pre-training stage doesn't need large samples simultaneously, and small samples parallel training reduces the probability of falling into the local minimum.

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K-Means Clustering Optimizing Deep Stacked Sparse Autoencoder

Abstract

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Impacts of a shared book-reading intervention for Italian-speaking children with developmental language disorder.

CONCLUSIONS & IMPLICATIONS: The present parent-based SBR intervention for Italian-speaking preschoolers with DLD showed effects, albeit modest, on both maternal and child communicative behaviours. The results suggest that extralinguistic strategies may be implemented successfully by parents and may be effective in enhancing children's engagement and language production in the short term. Further investigations are needed that provide a longer intervention period and examine the joint impact of therapist- and parent-based intervention for children with DLD. PMID: 30729644 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)

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Impacts of a shared book-reading intervention for Italian-speaking children with developmental language disorder.

Three-dimensional skeletal changes after early proportional condylectomy for condylar hyperplasia

The purpose of this study was to evaluate volumetric and dentoskeletal changes in 21 patients with active unilateral condylar hyperplasia (AUCH) after proportional condylectomy. A split-mouth design was used: control group healthy joints (HS, healthy side) and test group affected joints (AS, affected side) (21 per group). Cone beam tomography scans were obtained at T0 (preoperative), T1 (10days after the intervention), and T2 (approximately 12 months post-surgery). The condylar unit volume (CUV), articular cavity volume (ACV), and dentoalveolar units (DAUs) were measured.

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Learning condyle repositioning during orthognathic surgery with a surgical navigation system

Condyle repositioning during bilateral sagittal splint osteotomy (BSSO) is a challenging step for the inexperienced surgeon. We aimed to demonstrate the benefit of navigation for learning the condyle repositioning. We treated 100 patients who underwent a BSSO. A trainee performed the condyle repositioning of one side in two phases. In the first one, the trainee positioned without watching the screen of the Orthopilot Navigation system (ONS). In the second one, the trainee could use the ONS to replace the condyle.

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Learning condyle repositioning during orthognathic surgery with a surgical navigation system

Three-dimensional skeletal changes after early proportional condylectomy for condylar hyperplasia

Management of velopharyngeal insufficiency by modified Furlow palatoplasty with pharyngeal flap: a retrospective outcome review

The surgical approach for the correction of residual velopharyngeal insufficiency requiring secondary surgery at Chang Gung Memorial Hospital is the modified Furlow palatoplasty with pharyngeal flap (mFP-PF). The aim of this study was to describe the mFP-PF technique and to determine the results obtained with regard to improvements in velopharyngeal function in patients undergoing this surgery. This retrospective analysis included 58 non-syndromic patients treated during the period 1992–2015 who complained of hypernasal speech after primary cleft palate repair and failed postoperative speech therapy.

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Management of velopharyngeal insufficiency by modified Furlow palatoplasty with pharyngeal flap: a retrospective outcome review

Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus

Abstract

Objectives

Oral lichen planus (OLP) is a chronic inflammatory condition with an unclear pathological mechanism. IκB kinase α (IKKα)‐regulated mammary serine protease inhibitor (MASPIN) has been shown to mediate inflammation, particularly in cancers. Here, we explored the expression of MASPIN in OLP and its role in the inflammatory response.

Materials and Methods

Immunohistochemistry staining and reverse transcription‐polymerase chain reaction assays were used to detect the subcellular localisation and expression of MASPIN and IKKα in OLP and healthy control tissues. Levels of the inflammatory factors were compared with enzyme‐linked immunosorbent assays. MASPIN and IKKα were overexpressed and silenced, respectively, in an inflammation model of human oral keratinocytes (HOKs) stimulated with lipopolysaccharide (LPS).

Results

MASPIN expression was down‐regulated, whereas IKKα expression was up‐regulated in OLP tissues (P < 0.01). The levels of tumour necrosis factor‐alpha and interleukin‐6 in OLP tissues were increased compared to those of healthy controls (P < 0.01). MASPIN overexpression in LPS‐stimulated HOK cells inhibited the levels of IKKα and the secretion of inflammatory cytokines. By contrast, IKKα silencing promoted the expression of MASPIN and inhibited the secretion of inflammatory cytokines.

Conclusion

Both MASPIN and IKKα are involved in the inflammatory process of OLP, suggesting potential therapeutic targets.

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Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus

Abstract

Objectives

Materials and Methods

Results

Conclusion

Both MASPIN and IKKα are involved in the inflammatory process of OLP, suggesting potential therapeutic targets.

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A strategy for high‐dimensional multivariable analysis classifies childhood asthma phenotypes from genetic, immunological and environmental factors

Abstract

Background

Associations between childhood asthma phenotypes and genetic, immunological and environmental factors have been previously established. Yet, strategies to integrate high‐dimensional risk factors from multiple distinct data sets, and thereby increase the statistical power of analyses, have been hampered by a preponderance of missing data and lack of methods to accommodate them.

Methods

We assembled questionnaire, diagnostic, genotype, microarray, RT‐qPCR, flow cytometry and cytokine data (referred to as data modalities) to use as input factors for a classifier that could distinguish healthy children, mild‐to‐moderate allergic asthmatics and non‐allergic asthmatics. Based on data from 260 German children aged 4‐14 from our university outpatient clinic, we built a novel multi‐level prediction approach for asthma outcome which could deal with a present complex missing data structure.

Results

The optimal learning method was boosting based on all data sets, achieving an area‐underneath‐the‐receiver‐operating‐characteristic curve (AUC) for three classes of phenotypes of 0.81 (95%‐confidence interval (CI): 0.65‐0.94) using leave‐one‐out cross‐validation. Besides improving the AUC, our integrative multi‐level learning approach led to tighter CIs than using smaller complete predictor data sets (AUC=0.82[0.66‐0.94] for boosting). The most important variables for classifying childhood asthma phenotypes comprised novel identified genes, namely PKN2 (protein kinase N2), PTK2 (protein tyrosine kinase 2), and ALPP (alkaline phosphatase, placental).

Conclusion

Our combination of several data modalities using a novel strategy improved classification of childhood asthma phenotypes but requires validation in external populations. The generic approach is applicable to other multi‐level data‐based risk prediction settings, which typically suffer from incomplete data.

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Follow‐up, 18 months off HDM immunotherapy, of a randomized controlled study on the primary prevention of atopy

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Delayed drug hypersensitivity to bortezomib: desensitization and tolerance to its analogue carfilzomib

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Septocutaneous perforator mapping and clinical applications of the medial arm flap

The medial arm flap has a long history but remains underused despite providing multiple advantages. We reviewed our experience with using the medial arm flap in order to clarify the distribution of septocutaneous perforators and its relationship with pedicled flap design.

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Digital Model Simulation Technology for Ear Reconstruction of Microtia with Craniofacial Asymmetry

Craniofacial asymmetry is often observed in microtia patients, duing to the accompanied craniofacial microsomia deformity, such as mandibular dysplasia and/or depression of the mastoid region, which makes it difficult to obtain symmetrical results in ear reconstruction [1]. In the process of reconstruction, both ear location and framework fabrication are interfered by the asymmetry. Mandibular hypoplasia and the heterotopic residual ear can not be regarded as an appropriate locating reference, which poses difficulties to the surgeon when determining the location for the reconstructed ear.

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Post mastectomy upper limb lymphedema: combined vascularized lymph node transfer and scar release with fat graft expedites surgical and patients’ related outcomes. a retrospective comparative study

Lymphedema resulting from breast cancer treatment is a chronic condition which can significantly compromise quality of life. Several works have documented the efficacy of vascularized lymph node flap transfer (VLNT) for the treatment of advanced stage lymphedema. Given that the axillary scar may contribute to the patient's existing lymphedema, authors assumed that combining VLNT and scar release with fat graft could be an effective strategy of treatment. The purpose of this study is to compare the efficacy in limb's circumference reduction and health-related quality of life between a combined strategy, namely VLN and axillary scar release with fat grafting, and just VLN transfer for patients' affected by post mastectomy upper limb lymphedema.

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Carbon dioxide laser treatment in burn-related scarring: a prospective randomised controlled trial

To investigate the effect of ablative fractional CO2 laser (AFCO2L) on burns scar appearance and dermal architecture at 6 weeks and up to 3-years post-treatment.

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“SCARLESS REVERSE UMBILICOPLASTY”: A NEW TECHNIQUE OF UMBILICAL TRANSPOSITION IN ABDOMNOPLASTY

The navel plays a major role in the aesthetics of the abdomen. A navel which is abnormally shaped, malpositioned or has evident scarring may compromise the outcome of an otherwise well executed full abdominoplasty. The aim of the technique in question is to recreate a navel that looks natural, with no visible scar and properly positioned.

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Revisiting the reconstructive surgery framework: the reconstruction supermarket

Plastic and reconstructive surgeons apply a variety of techniques throughout the body with analogies having evolved to provide a conceptual framework for the selection of techniques. Well-known examples include: the reconstructive ladder with increasingly complex rungs, the reconstructive elevator where the surgeon moves directly to the most suitable reconstruction, the reconstructive toolbox, and the reconstructive triangle.1,2 Extended models have been proposed to incorporate developments such as negative pressure wound therapy, and include the extended ladder,3 the reconstructive solar system,4 and the reconstructive clockwork.

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A strategy for high‐dimensional multivariable analysis classifies childhood asthma phenotypes from genetic, immunological and environmental factors

Abstract

Background

Methods

Results

Conclusion

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Follow‐up, 18 months off HDM immunotherapy, of a randomized controlled study on the primary prevention of atopy

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Delayed drug hypersensitivity to bortezomib: desensitization and tolerance to its analogue carfilzomib

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Septocutaneous perforator mapping and clinical applications of the medial arm flap

Digital Model Simulation Technology for Ear Reconstruction of Microtia with Craniofacial Asymmetry

Post mastectomy upper limb lymphedema: combined vascularized lymph node transfer and scar release with fat graft expedites surgical and patients’ related outcomes. a retrospective comparative study

Carbon dioxide laser treatment in burn-related scarring: a prospective randomised controlled trial

“SCARLESS REVERSE UMBILICOPLASTY”: A NEW TECHNIQUE OF UMBILICAL TRANSPOSITION IN ABDOMNOPLASTY

Revisiting the reconstructive surgery framework: the reconstruction supermarket

Examining adjuvant radiation dose in head and neck squamous cell carcinoma

Abstract

Background

Compare adjuvant radiation dose trends and outcomes in head and neck squamous cell carcinoma (HNSCC).

Methods

Nonmetastatic HNSCCs treated between 2004 and 2014 with primary site surgery, lymph node dissection, and adjuvant radiation were identified in the National Cancer Database. Standard dose radiation (SD‐RT) was defined as an equivalent dose in 2 Gy (EQD2) ≥56.64 and ≤60 Gy and high‐dose radiation (HD‐RT) as an EQD2 >60 and <70 Gy.

Results

HD‐RT was given to 46% of the 15 836 HNSCC patients managed with adjuvant radiation. When adjusted for poor prognostic factors, HD‐RT was associated with increased mortality (HR1.09; 95%CI 1.02‐1.16). In nonoropharynx or human papillomavirus‐negative oropharynx primary that had positive margins, ≥5 positive lymph nodes, and/or extranodal extension, HD‐RT was still not associated with improved survival (HR 1.01, 95% CI 0.91‐1.12).

Conclusions

There was no survival benefit from postoperative dose escalation above EQD2 60 Gy even in a high‐risk cohort.

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Dynamic changes in chemosensitivity immune predictors in patients with hypopharyngeal cancer treated with induction chemotherapy

Abstract

Background

There are currently no data predicting chemosensitivity of induction chemotherapy (ICT) for hypopharyngeal squamous cell carcinomas (SCC).

Methods

Associations between immune cells and overall response (OR) to ICT and changes in immune cells during ICT were observed in 40 patients with hypopharyngeal SCC undergoing ICT.

Results

CD4⁺ and CD8⁺ T‐cell and regulatory T‐cell (Treg) frequencies reached diagnostic accuracy for OR to ICT. OR rate was significantly higher in CD4⁺‐high T cell, CD8⁺‐high T cell, and low Treg groups. A transient reduction in Tregs and increases in Tregs in the non‐OR and OR groups were observed during the course of ICT. Conversely, increases in CD8⁺ T cells and reductions in CD8⁺ T cells in the non‐OR and OR groups were observed.

Conclusion

High CD4⁺ T‐cell, high CD8⁺ T‐cell, and low Treg frequencies can be predictors for high efficacy of ICT in patients with hypopharyngeal SCC.

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Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma

Abstract

Background

The purpose of this analysis is to evaluate whether postoperative radiotherapy (PORT) at the same facility as surgery portends to better survival outcomes compared to PORT given at a different facility.

Methods

Patients underwent upfront surgery at the National Cancer Database reporting facility followed by PORT. PORT was coded as performed at either the same facility or at a different facility as surgery.

Results

A total of 10 832 patients were selected. Five‐year overall survival (OS) was higher in patients undergoing PORT at the same facility: 52.5% vs 48.4% (P < 0.001). PORT performed at the same facility was associated with improved OS under multivariate (HR, 0.92; P = 0.01) and propensity score matched (hazard ratio, 0.90; P = 0.004) analyses.

Conclusions

OS was better among patients with head and neck cancer who received PORT at the same facility as surgery.

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The role of age in treatment‐related adverse events in patients with head and neck cancer: A systematic review

Abstract

Head and neck squamous cell carcinoma (HNSCC) is often diagnosed in advanced stage and therefore requires aggressive, multimodal treatment. Elderly patients are often excluded from standard therapy regimens purely based on age. This clinical review aims to collect all published data in the literature on treatment modality selection in elderly patients and on age‐related adverse events following treatment of HNSCC. We performed a literature search for articles on the treatment of HNSCC in elderly patients. Most of the articles were retrospective studies with the consequent limitations. It can be concluded that age is not an absolute contraindication for intensive treatment and comorbidity is an important predictor of outcome, but not the only one. Despite the existence of multiple tools for pretreatment evaluation, there are not consistent data on their use.

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Outcomes and cost implications of microvascular reconstructions of the head and neck

Abstract

Background

Critical review of current head and neck reconstructive practices as related to free flap donor sites and their impact on clinical outcomes and cost.

Methods

Retrospective multicenter review of free tissue transfer reconstruction of head and neck defects (n = 1315). Variables reviewed: defect, indication, T classification, operative duration, and complications. A convenience sample was selected for analysis of overall (operative and inpatient admission) charges per hospitalization (n = 400).

Results

Mean charges of hospitalization by donor tissue: radial forearm free flap (RFFF) $127 636 (n = 183), osteocutaneous RFFF (OCRFFF) $125 456 (n = 70), anterior lateral thigh $133 781 (n = 54), fibula $140 747 (n = 42), latissimus $208 890 (n = 24), rectus $169 637 (n = 18), scapula $128 712 (n = 4), and ulna $110 716 (n = 5; P = .16). Mean operative times for malignant lesions stratified by T classification: 6.9 hours (±25 minutes) for T1, 7.0 hours (±16 minutes) for T2, 7.3 hours (±17 minutes) for T3, and 7.8 hours (±11 minutes) for T4 (P < .0001). Complications correlated with differences in mean charges: minor surgical ($123 720), medical ($216 387), and major surgical ($169 821; P < .001). Operations for advanced malignant lesions had higher mean charges: T1 lesions ($106 506) compared to T2/T3 lesions ($133 080; P = .03) and T4 lesions ($142 183; P = .02). On multivariate analysis, the length of stay, operative duration, and type a postoperative complication were factors affecting overall charges for the hospitalization (P < .018).

Conclusion

Conclusion: The RFFF and OCRFFF had the lowest complication rates, length of hospitalization, duration of operation, and mean charges of hospitalization. Advanced stage malignant disease correlated with increased hospitalization length, operative time, and complication rates resulting in higher hospitalization charges.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SAbAW3

Examining adjuvant radiation dose in head and neck squamous cell carcinoma

Abstract

Background

Compare adjuvant radiation dose trends and outcomes in head and neck squamous cell carcinoma (HNSCC).

Methods

Results

Conclusions

There was no survival benefit from postoperative dose escalation above EQD2 60 Gy even in a high‐risk cohort.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SFecSq

Dynamic changes in chemosensitivity immune predictors in patients with hypopharyngeal cancer treated with induction chemotherapy

Abstract

Background

There are currently no data predicting chemosensitivity of induction chemotherapy (ICT) for hypopharyngeal squamous cell carcinomas (SCC).

Methods

Associations between immune cells and overall response (OR) to ICT and changes in immune cells during ICT were observed in 40 patients with hypopharyngeal SCC undergoing ICT.

Results

Conclusion

High CD4⁺ T‐cell, high CD8⁺ T‐cell, and low Treg frequencies can be predictors for high efficacy of ICT in patients with hypopharyngeal SCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MXh1sF

Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma

Abstract

Background

Methods

Patients underwent upfront surgery at the National Cancer Database reporting facility followed by PORT. PORT was coded as performed at either the same facility or at a different facility as surgery.

Results

Conclusions

OS was better among patients with head and neck cancer who received PORT at the same facility as surgery.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SFe8Ca

The role of age in treatment‐related adverse events in patients with head and neck cancer: A systematic review

Abstract

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MXgVBj

Outcomes and cost implications of microvascular reconstructions of the head and neck

Abstract

Background

Critical review of current head and neck reconstructive practices as related to free flap donor sites and their impact on clinical outcomes and cost.

Methods

Results

Conclusion

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SAbAW3

Realization and representation of Nepali laryngeal contrasts: Voiced aspirates and laryngeal realism

In this study we push laryngeal realist theory in a new direction – to segments proposed to be specified for both [voice] and [spread] features – a combination which poses challenges to the current diagnostics. To do so, we analyze acoustic data from Nepali, an Indic (a.k.a. Indo-Aryan) language with a single class of stops described as both voiced and aspirated. We apply the same criteria and diagnostics used in laryngeal realism. We find support for the proposed representation, with a caveat that the [voice] feature appears 'stronger' than [spread]. (Source: Journal of Phonetics)

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Do Children Recall Numbers as Generic? A Strong Test of the Generics-As-Default Hypothesis

. (Source: Language Learning and Development)

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Exploring participation experiences of youth who use AAC in social media settings: impact of an e-mentoring intervention.

Authors: Grace E, Raghavendra P, McMillan JM, Gunson JS Abstract The contribution of cross-age peer e-mentoring on reported experiences of participation during online conversations using social media was explored in this pre-experimental study. Young people (n = 4, aged 13; 4-18;3 [years; months]) who used augmentative and alternative communication (AAC) participated in an e-mentoring intervention. Two mentors who also used AAC had regular conversations with the participants via Facebook 1 , email, or Skype 2 . It was predicted that the mentoring support would contribute to experiences of participation in online conversations outside of the e-mentoring intervention. Reported experiences of participation in online conversations with communication partners other than the mentor w...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WV88V5

Loudness Trumps Pitch in Politeness Judgments: Evidence from Korean Deferential Speech.

Authors: Idemaru K, Winter B, Brown L, Oh GE Abstract Social meaning is not conveyed through words alone, but also through how words are produced phonetically. This paper investigates the role of loudness and pitch in determining the perception of politeness-related judgments in Korean. It has been proposed that high pitch is universally associated with polite or deferential social meanings. In contrast to this, Experiment 1 examined the perceptual effect of pitch and found no effect. Experiment 2 tested the effect of loudness, and found that listeners associate quieter speech with deference. Finally, Experiment 3 investigated the simultaneous effects of loudness and pitch, and found again that loudness had a consistent effect, whereas pitch only had a weak effect. Analyses of indi...

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Realization and representation of Nepali laryngeal contrasts: Voiced aspirates and laryngeal realism

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WTsKgp

Do Children Recall Numbers as Generic? A Strong Test of the Generics-As-Default Hypothesis

. (Source: Language Learning and Development)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RTIXOY

Exploring participation experiences of youth who use AAC in social media settings: impact of an e-mentoring intervention.

Loudness Trumps Pitch in Politeness Judgments: Evidence from Korean Deferential Speech.

Dental injuries in patients associated with fracture of facial bones

ConclusionDifferent types of tooth injuries associated with facial bone fracture found more in females and maxillary teeth. (Source: Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SGuavI

Assessing Gait Stability before and after Cochlear Implantation.

Authors: Kaczmarczyk K, Błażkiewicz M, Wiszomirska I, Pietrasik K, Zdrodowska A, Wit A, Barton G, Skarżyński H Abstract Background: It is known that cochlear implantation may alter the inner ear and induce vestibular disorders. Research Question: How does cochlear implantation influence gait stability? Material and Methods. An experimental group of twenty-one subjects scheduled for cochlear implantation underwent gait testing twice, on the day before cochlear implantation (BCI) and three months after cochlear implantation (ACI), using a motion capture system. A control group of 30 age-matched healthy individuals were also tested. Results: In the experimental group, the gait stability ratio (GSR) was found to improve in 17 subjects after implantation, by an average of 6%...

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Robotic cochlear implantation: feasibility of a multiport approach in an ex vivo model

ConclusionsElectrode insertion through a robotic three-port approach is feasible. Drill tunnels through the facial recess for the electrode and endoscope allow for optimized insertion angles and sufficient visualization. Through a retrofacial tunnel effective manipulation for sealing is possible. (Source: European Archives of Oto-Rhino-Laryngology)

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Changes in Maxillary Sinus Volume and It ’s Walls Thickness Due to Chronic Rhinosinusitis: A Prospective Study

AbstractThis is a prospective observational cross sectional study comprising of 57 patients who were having symptoms of chronic rhinosinusitis which were evaluated with the help of computed tomography scan (coronal and axial sections) to measure the thickness of all walls of maxillary sinus and it 's volume. Computed tomographic imaging of sinonasal region has become the gold standard in the evaluation of patients with chronic sinusitis. The maxillary sinus is pyramidal in shape with lateral wall of nose forming its base and its apex is directed towards zygomatic process. All three dimensio ns of the maxillary sinus were measured and the volume of each maxillary sinus was also calculated. Hyperostosis of maxillary sinus tended to increase maxillary sinus walls thickness which ultimately ...

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Dental injuries in patients associated with fracture of facial bones

Assessing Gait Stability before and after Cochlear Implantation.

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Robotic cochlear implantation: feasibility of a multiport approach in an ex vivo model

Changes in Maxillary Sinus Volume and It ’s Walls Thickness Due to Chronic Rhinosinusitis: A Prospective Study

Radiographic scoring methods in rheumatoid arthritis and psoriatic arthritis

Abstract

Structural changes of bone and cartilage are the hallmarks of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Radiography can help in making diagnosis and in differentiating PsA and RA from other articular diseases. Radiography is still considered the preferred imaging method to assess disease progression, reflecting cumulative damage over time. The presence of bone erosions in RA is as an indicator of irreversible articular damage. Radiographic features of PsA are characteristic and differ from those observed in RA, especially in the distribution of affected joints and in the presence of destructive changes and bone proliferation at the same time. Semiquantitative scoring methods are designed to measure the degree of radiographically detectable joint damage and of changes over time. Several radiographic scoring methods that had been developed originally for RA have been adopted for the use in PsA. This review discusses the use of conventional radiography for diagnosing and detecting early structural changes in RA and PsA and providing a historical overview of commonly used scoring methods.

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Radiographic scoring methods in rheumatoid arthritis and psoriatic arthritis

Abstract

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Robotic cochlear implantation: feasibility of a multiport approach in an ex vivo model

Abstract

Purpose

A recent clinical trial has shown the feasibility of robotic cochlear implantation. The electrode was inserted through the robotically drilled tunnel and an additional access through the external auditory canal was created to provide for means of visualization and manipulation. To obviate the need for this additional access, the utilization of multiple robotically drilled tunnels targeting the round window has been proposed. The objective of this study was to assess the feasibility of electrode insertion through a robotic multiport approach.

Methods

In four ex vivo human head specimens (left side), four trajectories through the facial recess (2x) and the retrofacial and suprameatal region were planned and robotically drilled. Optimal three-port configurations were determined for each specimen by analyzing combinations of three of the four trajectories, where the three trajectories were used for the electrode, endoscopic visualization and manipulative assistance. Finally, electrode insertions were conducted through the optimal configurations.

Results

The electrodes could successfully be inserted, and the procedure sufficiently visualized through the facial recess drill tunnels in all specimens. Effective manipulative assistance for sealing the round window could be provided through the retrofacial tunnel.

Conclusions

Electrode insertion through a robotic three-port approach is feasible. Drill tunnels through the facial recess for the electrode and endoscope allow for optimized insertion angles and sufficient visualization. Through a retrofacial tunnel effective manipulation for sealing is possible.

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Robotic cochlear implantation: feasibility of a multiport approach in an ex vivo model

Abstract

Purpose

Methods

Results

Conclusions

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UJvyee

Cochlear ablation in neonatal rats disrupts inhibitory transmission in the medial nucleus of the trapezoid body

Publication date: Available online 8 February 2019Source: Neuroscience LettersAuthor(s): Bohdana Hruskova, Johana Trojanova, Michaela Kralikova, Adolf Melichar, Stepanka Suchankova, Jolana Bartosova, Jana Svobodova Burianova, Jiri Popelar, Josef Syka, Rostislav TurecekAbstractInhibitory circuits in the auditory brainstem undergo multiple postnatal changes that are both activity-dependent and activity-independent. We tested to see if the shift from GABA- to glycinergic transmission, which occurs in the rat medial nucleus of the trapezoid body (MNTB) around the onset of hearing, depends on sound-evoked neuronal activity. We prevented the activity by bilateral cochlear ablations in early postnatal rats and studied ionotropic GABA and glycine receptors in MNTB neurons after hearing onset. The ...

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Long-term Conductive Auditory Deprivation During Early Development Causes Irreversible Hearing Impairment and Cochlear Synaptic Disruption

In this study, a mouse model of conductive auditory deprivation (CAD) was achieved using external auditory canal closure on postnatal day 12, which marks the onset of external ear canal opening. Short-term (2 weeks) and long-term (6 weeks) deprivations involving external ear canal closure were conducted. Mice were examined immediately, 4 weeks, and 8 weeks after deprivation. Short-term deprivation induced reversible auditory brainstem response (ABR) threshold and latencies of ABR wave I, whereas long-term deprivation caused irreversible ABR thresholds and latencies of ABR wave I. Complete recovery of ribbon synapses and latencies of ABR wave I were observed in the short-term group. In contrast, we observed irreversible ABR thresholds, latencies of ABR wave I, and quantity of ribbon synapse...

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Cochlear ablation in neonatal rats disrupts inhibitory transmission in the medial nucleus of the trapezoid body

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Long-term Conductive Auditory Deprivation During Early Development Causes Irreversible Hearing Impairment and Cochlear Synaptic Disruption

Validation of the Thai version of the family reported outcome measure (FROM-16)© to assess the impact of disease on the partner or family members of patients with cancer

Cancer not only impairs a patient's physical and psychosocial functional behaviour, but also contributes to negative impact on family members' health related quality of life. Currently, there is an absence of ...

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Can physical activity compensate for low socioeconomic status with regard to poor self-rated health and low quality-of-life?

Both high socioeconomic status (SES) and high physical activity (PA) are associated with better self-rated health (SRH) and higher quality-of-life (QoL).

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Validation of the Thai version of the family reported outcome measure (FROM-16)© to assess the impact of disease on the partner or family members of patients with cancer

Πληροφορίες

Κυριακή 10 Φεβρουαρίου 2019

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Σάββατο 9 Φεβρουαρίου 2019

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