We present a patient with a de novo coding variant and unexpected phenotype. (Source: Journal of Allergy and Clinical Immunology)
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Δευτέρα 11 Φεβρουαρίου 2019
Granulomatosis with Polyangiitis and Severe Systemic Eosinophilia Due to a Novel PIK3CD mutation
Decreased monocytic TNF-a, IL-6 and IL-b after 72 hours of injury lead to positive outcome in severely injured trauma patients
Trauma is one of the leading causes of mortality worldwide with infections as important causes of death. Therefore, the present study was designed to monitor the peripheral blood monocytic activity to produce cytokines (TNF- α, IL-6& IL-1 β) during the acute post-traumatic period and to correlate with clinical outcome of these patients. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DsSreZ
Change in Peanut Skin Prick Testing Over Time in Infants at Risk for Food Allergy Who Continue to Avoid Peanut
Current guidelines recommend early peanut introduction to all infants, with physician supervised introduction for those with skin prick test (SPT) 3-8mm. Many of these infants will have supervised introduction deferred to a subsequent visit and some never return for follow-up. It is currently unknown if and how peanut SPT results change over time in infants. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sr7h02
Staphylococcus Aureus Induces IL-33, TSLP, and Muc5AC production by AERD Nasal Epithelium
Although Methicillin Resistant Staphylococcus aureus(MRSA) is associated with chronic rhinosinusitis (CRS), causative role and mechanism of MRSA leading to chronic inflammation seen in CRS has yet to be elucidated. Nasal epithelium provides the first line of defense in differentiating pathogenic from commensal bacteria. Increased permeability of nasal epithelium, decreased antimicrobial production and impaired mucociliary clearance are features of CRS. Regenerating islet-derived protein 3 gamma (Reg3g) is a C-type lectin with antimicrobial activity against MRSA. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DxtDCq
An Intramural Review to Support Research and Scientific Publication
Academic careers drive science through accurate and effective written communication of novel ideas and research findings. Publishing in high impact journals is one of the foundations for success. However, effective, scientific writing skills are rarely taught. IMpact | An Intramural Review to Support Research and Scientific Publication is designed to provide support for scholarly writing at the University of South Florida (USF), a concept introduced by the USF Division of Allergy and Immunology. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqSySB
The NMR structure and IgE Epitopes of Ara h 1 Leader Sequence
The vicilins from peanut, walnut, cashew and pistachio are considered major allergens and are translated with leader sequences (LS) that are cleaved before yielding the mature protein. While previous work has shown that some contain immunodominant IgE epitopes, their structure has not been solved. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dub8ij
Incidence of Hypersensitivity to Cetuximab
Cetuximab is a monoclonal antibody to epidermal growth factor receptor primarily used as adjunctive treatment of metastatic cancers. Hypersensitivity reactions, including anaphylaxis, and especially in the southeastern part of the United States, are one of the most well-known adverse effects of cetuximab. The aim of this meta-analysis is to gain better insight into the overall incidence of cetuximab-induced hypersensitivity reactions. (Source: Journal of Allergy and Clinical Immunology)
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Clinical features of an FPIES cohort
This case series characterizes clinical features of food protein-induced enterocolitis syndrome (FPIES), a non-IgE-mediated food allergy that is often under-recognized. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DyErAk
Negligible Impact of Age, Sex, and Type of Allergen on Oral Food Challenge Passage Rate
The decision to proceed with an oral food challenge (OFC) to rule out IgE-mediated food allergy can be complex. While the patient 's medical history and family's preferences are important, information concerning passage rates among different allergens and ages may be helpful in guiding decision making. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2So82Xs
Evaluating Smartphone and Internet Access and Attitudes Towards Using Asthma Mobile Applications:A Qualitative Study Conducted in Gujarat, India
Approximately 10% of the world 's asthma sufferers live in India, and asthma is widely underdiagnosed in this country. Within a growing digital health market in India, smartphone and internet-based apps can help with asthma self-management. Few studies have reported smartphone and internet access among asthma sufferers in India , and there is a lack of data regarding patient attitudes towards patient-facing asthma self-management apps. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dt5rRY
Diagnosing children with mast cell activation (MCAS) with adult diagnostic criteria
Diagnostic criteria have been established to diagnose MCAS in adults, however, the guidelines for children are unclear. Here we present a case series of children who presented to our multi-disciplinary, allergy/gastroenterology (GI) clinic with symptoms suggestive of MCAS who were found to have laboratory evidence of mast cell activation. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqH5CI
Broad Immunglobulin G Repertoire in Chronic Rhinosinusitis with Nasal Polyps regulates pro-inflammatory IgE responses
Capsule Summary (Source: Journal of Allergy and Clinical Immunology)
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Can f 5 as a suitable marker of dog allergy: Assess male dog exposure before banning it
We read with interest the excellent article by K äck et al1 focusing on the role of different dog allergens in inducing nasal symptoms as assessed by nasal provocation tests (NPTs). It is well known that a significant percentage of individuals sensitized to dog allergens by skin prick tests do not develop overt respiratory symptoms (asthma and/o r rhinitis) after direct dog exposure. For this reason, NPTs can be regarded as the "criterion standard" to clarify whether a sensitization to dog allergens can be regarded clinically relevant. (Source: Journal of Allergy and Clinical Immunology)
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Reply
We have with great interest read the comment from Liccardi et al1 on our article recently published in the Journal.2 We share the opinion that the male dog allergen Can f 5 is an intriguing molecule that deserves further investigation. Sensitization to Can f 5 has in several studies been shown to play a role in respiratory allergy and it is known that monose nsitization to Can f 5 occurs in a considerable proportion of dog dander–sensitized individuals. In the current study of dog dander–sensitized children we found that monosensitization to Can f 5 was associated with a negative nasal provocation test (NPT) result with dog dander extract (odds rati o, 5.78; 95% CI, 1.01-33.0). (Source: Journal of Allergy and Clinical Immunology)
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Factors influencing Skin Prick Test Positivity in an Inner-City Pediatric Cohort (2013-2016)
This study examined the influence of adiposity and other factors on skin prick test (SPT) reactivity amongst inner-city children. (Source: Journal of Allergy and Clinical Immunology)
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Flagellin Induces Pro-inflammatory Cytokines, Chemokines and Metalloproteinases In Bronchial Epithelial Cells.
Flagellin which is abundant in gram-negative bacteria including pseudomonas is reported to be related with development of asthma. However, its effect on airway epithelial cells regarding asthma pathogenesis is not elucidated yet. We investigated the effect of flagellin on the production of cytokines, chemokines and metalloproteinase related with airway inflammation and remodeling in the primary human epithelial cells. (Source: Journal of Allergy and Clinical Immunology)
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IL-33 Plays a Key Role in Development of Antigen-specific Th2 Cells in Lung Tissues
Th2-type CD4+ T cells play important roles in allergic immune responses. The goal of this study was to investigate the immunologic mechanisms involved in development of Th2 cells to inhaled antigens by focusing on lung tissues. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sr7i46
Vocal Cord Dysfunction in Patients with Predominant Upper Airway Symptoms
Vocal cord dysfunction (VCD), a functional disorder characterized by abnormal and involuntary adduction of the vocal folds, can mimic asthma or other respiratory disorders. We analyzed a subset of VCD patients that presented with predominantly upper airway symptoms and were misdiagnosed as anaphylaxis. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Du188V
Perceived food allergy, sensitivity, or intolerance and its impact on breastfeeding practices
The impact of suspected allergic disease on breastfeeding duration is not well defined. The purpose of this study was to examine the association of reported infant adverse reactions to food with breastfeeding duration, and the impact of infant age and specific symptoms on this relationship. (Source: Journal of Allergy and Clinical Immunology)
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Impact of Omalizumab Treatment Withdrawal After 24 and 48 Weeks in Patients with Chronic Idiopathic Urticaria: Results From the XTEND-CIU Study
Omalizumab significantly reduces the frequency/severity of CIU symptoms. However, as 24 weeks represents the longest treatment period in pivotal trials, uncertainty exists regarding optimal treatment duration and clinical worsening predictors following cessation. (Source: Journal of Allergy and Clinical Immunology)
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Granulomatosis with Polyangiitis and Severe Systemic Eosinophilia Due to a Novel PIK3CD mutation
We present a patient with a de novo coding variant and unexpected phenotype. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqH8hS
Decreased monocytic TNF-a, IL-6 and IL-b after 72 hours of injury lead to positive outcome in severely injured trauma patients
Trauma is one of the leading causes of mortality worldwide with infections as important causes of death. Therefore, the present study was designed to monitor the peripheral blood monocytic activity to produce cytokines (TNF- α, IL-6& IL-1 β) during the acute post-traumatic period and to correlate with clinical outcome of these patients. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DsSreZ
Change in Peanut Skin Prick Testing Over Time in Infants at Risk for Food Allergy Who Continue to Avoid Peanut
Current guidelines recommend early peanut introduction to all infants, with physician supervised introduction for those with skin prick test (SPT) 3-8mm. Many of these infants will have supervised introduction deferred to a subsequent visit and some never return for follow-up. It is currently unknown if and how peanut SPT results change over time in infants. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sr7h02
Staphylococcus Aureus Induces IL-33, TSLP, and Muc5AC production by AERD Nasal Epithelium
Although Methicillin Resistant Staphylococcus aureus(MRSA) is associated with chronic rhinosinusitis (CRS), causative role and mechanism of MRSA leading to chronic inflammation seen in CRS has yet to be elucidated. Nasal epithelium provides the first line of defense in differentiating pathogenic from commensal bacteria. Increased permeability of nasal epithelium, decreased antimicrobial production and impaired mucociliary clearance are features of CRS. Regenerating islet-derived protein 3 gamma (Reg3g) is a C-type lectin with antimicrobial activity against MRSA. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DxtDCq
An Intramural Review to Support Research and Scientific Publication
Academic careers drive science through accurate and effective written communication of novel ideas and research findings. Publishing in high impact journals is one of the foundations for success. However, effective, scientific writing skills are rarely taught. IMpact | An Intramural Review to Support Research and Scientific Publication is designed to provide support for scholarly writing at the University of South Florida (USF), a concept introduced by the USF Division of Allergy and Immunology. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqSySB
The NMR structure and IgE Epitopes of Ara h 1 Leader Sequence
The vicilins from peanut, walnut, cashew and pistachio are considered major allergens and are translated with leader sequences (LS) that are cleaved before yielding the mature protein. While previous work has shown that some contain immunodominant IgE epitopes, their structure has not been solved. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dub8ij
Incidence of Hypersensitivity to Cetuximab
Cetuximab is a monoclonal antibody to epidermal growth factor receptor primarily used as adjunctive treatment of metastatic cancers. Hypersensitivity reactions, including anaphylaxis, and especially in the southeastern part of the United States, are one of the most well-known adverse effects of cetuximab. The aim of this meta-analysis is to gain better insight into the overall incidence of cetuximab-induced hypersensitivity reactions. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Stsiak
Clinical features of an FPIES cohort
This case series characterizes clinical features of food protein-induced enterocolitis syndrome (FPIES), a non-IgE-mediated food allergy that is often under-recognized. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DyErAk
Negligible Impact of Age, Sex, and Type of Allergen on Oral Food Challenge Passage Rate
The decision to proceed with an oral food challenge (OFC) to rule out IgE-mediated food allergy can be complex. While the patient 's medical history and family's preferences are important, information concerning passage rates among different allergens and ages may be helpful in guiding decision making. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2So82Xs
Evaluating Smartphone and Internet Access and Attitudes Towards Using Asthma Mobile Applications:A Qualitative Study Conducted in Gujarat, India
Approximately 10% of the world 's asthma sufferers live in India, and asthma is widely underdiagnosed in this country. Within a growing digital health market in India, smartphone and internet-based apps can help with asthma self-management. Few studies have reported smartphone and internet access among asthma sufferers in India , and there is a lack of data regarding patient attitudes towards patient-facing asthma self-management apps. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dt5rRY
Diagnosing children with mast cell activation (MCAS) with adult diagnostic criteria
Diagnostic criteria have been established to diagnose MCAS in adults, however, the guidelines for children are unclear. Here we present a case series of children who presented to our multi-disciplinary, allergy/gastroenterology (GI) clinic with symptoms suggestive of MCAS who were found to have laboratory evidence of mast cell activation. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqH5CI
Nasal soft tissue changes after two different approaches for surgically assisted rapid maxillary expansion
The aim of the study was to evaluate the nasal soft tissue changes in patients who underwent surgically assisted rapid maxillary expansion (SARME) using two different surgical approaches. Thirty-two patients were included in the study, and divided into two groups according to the type of surgical approach: in group A (n=17), SARME performed with standard Le Fort I circumvestibular approach with alar base cinch and anterior nasal spine (ANS) exposure; and in group B (n=15) operations were performed with the same standard Le Fort I circumvestibular approach with only alar base cinch.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SMmEiI
Nasal soft tissue changes after two different approaches for surgically assisted rapid maxillary expansion
The aim of the study was to evaluate the nasal soft tissue changes in patients who underwent surgically assisted rapid maxillary expansion (SARME) using two different surgical approaches. Thirty-two patients were included in the study, and divided into two groups according to the type of surgical approach: in group A (n=17), SARME performed with standard Le Fort I circumvestibular approach with alar base cinch and anterior nasal spine (ANS) exposure; and in group B (n=15) operations were performed with the same standard Le Fort I circumvestibular approach with only alar base cinch.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SMmEiI
Broad Immunglobulin G Repertoire in Chronic Rhinosinusitis with Nasal Polyps regulates pro-inflammatory IgE responses
Capsule Summary
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MYNfUq
Mouse Allergen Levels in Schools in Two Inner City Asthma Studies: Past versus Present
Higher mouse allergen levels in classrooms have been associated with increased asthma symptoms in students. This was demonstrated in a 5-year observational asthma school study. Two years after the conclusion of the study, a second asthma school study was launched in the same geographic area. We hypothesized that mouse allergen levels may have reduced between the 2 studies due to schools' self-motivation and improved pest reduction strategies.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SM7iuE
Broad Immunglobulin G Repertoire in Chronic Rhinosinusitis with Nasal Polyps regulates pro-inflammatory IgE responses
Capsule Summary
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MYNfUq
Mouse Allergen Levels in Schools in Two Inner City Asthma Studies: Past versus Present
Higher mouse allergen levels in classrooms have been associated with increased asthma symptoms in students. This was demonstrated in a 5-year observational asthma school study. Two years after the conclusion of the study, a second asthma school study was launched in the same geographic area. We hypothesized that mouse allergen levels may have reduced between the 2 studies due to schools' self-motivation and improved pest reduction strategies.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SM7iuE
Feasibility of transnasal flexible carbon dioxide laser surgery for laryngopharyngeal lesions
The fiber-guided carbon dioxide (CO2) laser is a useful device for laryngopharyngeal surgery. The flexible CO2 wave-guide laser has been developed and commercially available for several years. However, the transnasal use of CO2 flexible wave-guided laser surgery through the instrument channel of a flexible endoscope (CO2 TNFLS) is not permitted in Japan. This feasibility study aimed to assess the value and the safety of an in-office CO2 TNFLS procedure.
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Sialendoscopy plus laser lithotripsy in sialolithiasis of the submandibular gland in 64 patients: A simple and safe procedure
To demonstrate the safety and efficiency of holmium laser-assisted lithotripsy during sialendoscopy of the submandibular gland using a retrospective, interventional consecutive case series.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bw1tHY
Feasibility of transnasal flexible carbon dioxide laser surgery for laryngopharyngeal lesions
The fiber-guided carbon dioxide (CO2) laser is a useful device for laryngopharyngeal surgery. The flexible CO2 wave-guide laser has been developed and commercially available for several years. However, the transnasal use of CO2 flexible wave-guided laser surgery through the instrument channel of a flexible endoscope (CO2 TNFLS) is not permitted in Japan. This feasibility study aimed to assess the value and the safety of an in-office CO2 TNFLS procedure.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TIH7lN
Sialendoscopy plus laser lithotripsy in sialolithiasis of the submandibular gland in 64 patients: A simple and safe procedure
To demonstrate the safety and efficiency of holmium laser-assisted lithotripsy during sialendoscopy of the submandibular gland using a retrospective, interventional consecutive case series.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bw1tHY
Optimising Radiation Therapy Dose to the Swallowing Organs at Risk: An In Silico Study of feasibility for Patients with Oropharyngeal Tumours
This study found reducing dose to the SWOARs is a feasible practice for patients with oropharyngeal cancer. However, future prospective research is needed to determine if the extent of dose reduction achieved equates to clinical benefits. (Source: Dysphagia)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SoHwxf
Optimising Radiation Therapy Dose to the Swallowing Organs at Risk: An In Silico Study of feasibility for Patients with Oropharyngeal Tumours
This study found reducing dose to the SWOARs is a feasible practice for patients with oropharyngeal cancer. However, future prospective research is needed to determine if the extent of dose reduction achieved equates to clinical benefits. (Source: Dysphagia)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SoHwxf
Comparative Study of Nipple–Areola Complex Position and Patient Satisfaction After Unilateral Mastectomy and Immediate Expander–Implant Reconstruction Nipple-Sparing Mastectomy Versus Skin-Sparing Mastectomy
Abstract
Background
Major surgical concerns associated with nipple-sparing mastectomy (NSM) are partial or total nipple–areola complex (NAC) loss, decreased sensation, and nipple malposition. Patient satisfaction and NAC outcomes including malposition in patients who have undergone unilateral expander–implant reconstruction after NSM as compared with skin-sparing mastectomy (SSM) remain unclear. Therefore, the aim of this study was to assess patient satisfaction and NAC outcomes of breast cancer patients who underwent spared or reconstructed NAC after unilateral NSM as compared with unilateral SSM.
Methods
Patients who underwent immediate expander–implant breast reconstruction following unilateral NSM or SSM were included. Medical records of patients from April 2010 to February 2014 were retrospectively reviewed. Reconstruction-related complications such as infection, seroma, haematoma, delayed wound healing, and reconstruction failure were recorded. NAC outcome analysis was performed using preoperative and postoperative digital photographs for each patient. Patient satisfaction with the reconstructed breast and NAC was assessed using a study-specific questionnaire.
Results
Delayed wound healing occurred in 18 of 55 NSM patients and 15 of 85 SSM patients (p = 0.040). Final reconstruction failure occurred in 0 NSM patients and 6 SSM patients (p = 0.043). The mean photography analysis score of total aesthetic outcome was 13.12 ± 2.39 in the NSM group and 14.06 ± 2.75 in the SSM group (p = 0.052). The mean questionnaire score of NAC position was 2.88 ± 0.85 in the NSM group and 3.80 ± 0.84 in the SSM group (p = 0.001). The mean questionnaire score of NAC sensitivity was 2.12 ± 0.58 in the NSM group and 1.84 ± 0.46 in the SSM group (p = 0.003). Satisfaction with the reconstructed breast was similar (p = 0.913) after NSM and SSM.
Conclusions
We observed no significant difference in breast reconstruction satisfaction between the NSM and SSM groups. Although overall satisfaction with breast reconstruction is high, patients in the NSM group often report dissatisfaction with nipple position. With a favourable score for NAC position, skin-sparing mastectomy followed by NAC reconstruction can be considered as a balanced alternative to NSM for properly selected patients with breast cancer.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tfMVHX
Comparative Study of Nipple–Areola Complex Position and Patient Satisfaction After Unilateral Mastectomy and Immediate Expander–Implant Reconstruction Nipple-Sparing Mastectomy Versus Skin-Sparing Mastectomy
Abstract
Background
Major surgical concerns associated with nipple-sparing mastectomy (NSM) are partial or total nipple–areola complex (NAC) loss, decreased sensation, and nipple malposition. Patient satisfaction and NAC outcomes including malposition in patients who have undergone unilateral expander–implant reconstruction after NSM as compared with skin-sparing mastectomy (SSM) remain unclear. Therefore, the aim of this study was to assess patient satisfaction and NAC outcomes of breast cancer patients who underwent spared or reconstructed NAC after unilateral NSM as compared with unilateral SSM.
Methods
Patients who underwent immediate expander–implant breast reconstruction following unilateral NSM or SSM were included. Medical records of patients from April 2010 to February 2014 were retrospectively reviewed. Reconstruction-related complications such as infection, seroma, haematoma, delayed wound healing, and reconstruction failure were recorded. NAC outcome analysis was performed using preoperative and postoperative digital photographs for each patient. Patient satisfaction with the reconstructed breast and NAC was assessed using a study-specific questionnaire.
Results
Delayed wound healing occurred in 18 of 55 NSM patients and 15 of 85 SSM patients (p = 0.040). Final reconstruction failure occurred in 0 NSM patients and 6 SSM patients (p = 0.043). The mean photography analysis score of total aesthetic outcome was 13.12 ± 2.39 in the NSM group and 14.06 ± 2.75 in the SSM group (p = 0.052). The mean questionnaire score of NAC position was 2.88 ± 0.85 in the NSM group and 3.80 ± 0.84 in the SSM group (p = 0.001). The mean questionnaire score of NAC sensitivity was 2.12 ± 0.58 in the NSM group and 1.84 ± 0.46 in the SSM group (p = 0.003). Satisfaction with the reconstructed breast was similar (p = 0.913) after NSM and SSM.
Conclusions
We observed no significant difference in breast reconstruction satisfaction between the NSM and SSM groups. Although overall satisfaction with breast reconstruction is high, patients in the NSM group often report dissatisfaction with nipple position. With a favourable score for NAC position, skin-sparing mastectomy followed by NAC reconstruction can be considered as a balanced alternative to NSM for properly selected patients with breast cancer.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tfMVHX
Orofacial myofunctional evaluation in cleft lip and palate: an integrative literature review
Conclusion: speech was the prevalent theme, while other orofacial functions were poorly investigated, demonstrating that studies with other approaches were lacking.RESUMO Objetivo: identificar o enfoque das publica ções científicas na área de motricidade orofacial em indivíduos com fissura labiopalatina, bem como os protocolos validados utilizados na avaliação fonoaudiológica. Métodos: estudo realizado a partir das bases de dados: Medline, Scielo, Lilacs e ferramenta Google Acadêmico, por meio dos d escritores: fissura palatina + fenda labial + avaliação + fonoaudiologia + sistema estomatognático + fala + mastigação + respiração + estudos de validação, em português e inglês. Resultados: foram selecionados 572 artigos, no período de 2012 e 2017, que abordassem a avalia...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SqHGEj
Relationship between dizziness and learning difficulties in schoolchildren: an integrative review
Conclusion: the results of this integrative review showed a low level of scientific evidence on the relationship between dizziness and academic achievement in childhood. It is important to emphasize the importance of improving study design to better understand their relationship, to allow provision of the best preventive, assessment, and intervention methods.RESUMO Objetivo: verificar o n ível de evidência científica da relação entre a tontura e a aprendizagem em crianças. Métodos: a pesquisa foi realizada a partir dos seguintes descritores: " dizziness " , " vertigo " , " child " , " learning " , " spelling " , " learning skills " , " academic skills " , " reading " e seus correspondentes em l íngua portuguesa entre as bases de dados: PubMed, Scielo...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dwnqa8
Optimising Radiation Therapy Dose to the Swallowing Organs at Risk: An In Silico Study of feasibility for Patients with Oropharyngeal Tumours
This study found reducing dose to the SWOARs is a feasible practice for patients with oropharyngeal cancer. However, future prospective research is needed to determine if the extent of dose reduction achieved equates to clinical benefits. (Source: Dysphagia)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SoHwxf
The Lombard effect associated with Chinese male alaryngeal speech
. (Source: International Journal of Speech-Language Pathology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DuHoSI
Enhanced milieu teaching for children with autism spectrum disorder in South Africa
. (Source: International Journal of Speech-Language Pathology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Su6Wtt
Orofacial myofunctional evaluation in cleft lip and palate: an integrative literature review
Conclusion: speech was the prevalent theme, while other orofacial functions were poorly investigated, demonstrating that studies with other approaches were lacking.RESUMO Objetivo: identificar o enfoque das publica ções científicas na área de motricidade orofacial em indivíduos com fissura labiopalatina, bem como os protocolos validados utilizados na avaliação fonoaudiológica. Métodos: estudo realizado a partir das bases de dados: Medline, Scielo, Lilacs e ferramenta Google Acadêmico, por meio dos d escritores: fissura palatina + fenda labial + avaliação + fonoaudiologia + sistema estomatognático + fala + mastigação + respiração + estudos de validação, em português e inglês. Resultados: foram selecionados 572 artigos, no período de 2012 e 2017, que abordassem a avalia...
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Relationship between dizziness and learning difficulties in schoolchildren: an integrative review
Conclusion: the results of this integrative review showed a low level of scientific evidence on the relationship between dizziness and academic achievement in childhood. It is important to emphasize the importance of improving study design to better understand their relationship, to allow provision of the best preventive, assessment, and intervention methods.RESUMO Objetivo: verificar o n ível de evidência científica da relação entre a tontura e a aprendizagem em crianças. Métodos: a pesquisa foi realizada a partir dos seguintes descritores: " dizziness " , " vertigo " , " child " , " learning " , " spelling " , " learning skills " , " academic skills " , " reading " e seus correspondentes em l íngua portuguesa entre as bases de dados: PubMed, Scielo...
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Optimising Radiation Therapy Dose to the Swallowing Organs at Risk: An In Silico Study of feasibility for Patients with Oropharyngeal Tumours
This study found reducing dose to the SWOARs is a feasible practice for patients with oropharyngeal cancer. However, future prospective research is needed to determine if the extent of dose reduction achieved equates to clinical benefits. (Source: Dysphagia)
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The Lombard effect associated with Chinese male alaryngeal speech
. (Source: International Journal of Speech-Language Pathology)
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Enhanced milieu teaching for children with autism spectrum disorder in South Africa
. (Source: International Journal of Speech-Language Pathology)
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Comparative Study of Nipple–Areola Complex Position and Patient Satisfaction After Unilateral Mastectomy and Immediate Expander–Implant Reconstruction Nipple-Sparing Mastectomy Versus Skin-Sparing Mastectomy
Abstract
Background
Major surgical concerns associated with nipple-sparing mastectomy (NSM) are partial or total nipple–areola complex (NAC) loss, decreased sensation, and nipple malposition. Patient satisfaction and NAC outcomes including malposition in patients who have undergone unilateral expander–implant reconstruction after NSM as compared with skin-sparing mastectomy (SSM) remain unclear. Therefore, the aim of this study was to assess patient satisfaction and NAC outcomes of breast cancer patients who underwent spared or reconstructed NAC after unilateral NSM as compared with unilateral SSM.
Methods
Patients who underwent immediate expander–implant breast reconstruction following unilateral NSM or SSM were included. Medical records of patients from April 2010 to February 2014 were retrospectively reviewed. Reconstruction-related complications such as infection, seroma, haematoma, delayed wound healing, and reconstruction failure were recorded. NAC outcome analysis was performed using preoperative and postoperative digital photographs for each patient. Patient satisfaction with the reconstructed breast and NAC was assessed using a study-specific questionnaire.
Results
Delayed wound healing occurred in 18 of 55 NSM patients and 15 of 85 SSM patients (p = 0.040). Final reconstruction failure occurred in 0 NSM patients and 6 SSM patients (p = 0.043). The mean photography analysis score of total aesthetic outcome was 13.12 ± 2.39 in the NSM group and 14.06 ± 2.75 in the SSM group (p = 0.052). The mean questionnaire score of NAC position was 2.88 ± 0.85 in the NSM group and 3.80 ± 0.84 in the SSM group (p = 0.001). The mean questionnaire score of NAC sensitivity was 2.12 ± 0.58 in the NSM group and 1.84 ± 0.46 in the SSM group (p = 0.003). Satisfaction with the reconstructed breast was similar (p = 0.913) after NSM and SSM.
Conclusions
We observed no significant difference in breast reconstruction satisfaction between the NSM and SSM groups. Although overall satisfaction with breast reconstruction is high, patients in the NSM group often report dissatisfaction with nipple position. With a favourable score for NAC position, skin-sparing mastectomy followed by NAC reconstruction can be considered as a balanced alternative to NSM for properly selected patients with breast cancer.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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Comparative Study of Nipple–Areola Complex Position and Patient Satisfaction After Unilateral Mastectomy and Immediate Expander–Implant Reconstruction Nipple-Sparing Mastectomy Versus Skin-Sparing Mastectomy
Abstract
Background
Major surgical concerns associated with nipple-sparing mastectomy (NSM) are partial or total nipple–areola complex (NAC) loss, decreased sensation, and nipple malposition. Patient satisfaction and NAC outcomes including malposition in patients who have undergone unilateral expander–implant reconstruction after NSM as compared with skin-sparing mastectomy (SSM) remain unclear. Therefore, the aim of this study was to assess patient satisfaction and NAC outcomes of breast cancer patients who underwent spared or reconstructed NAC after unilateral NSM as compared with unilateral SSM.
Methods
Patients who underwent immediate expander–implant breast reconstruction following unilateral NSM or SSM were included. Medical records of patients from April 2010 to February 2014 were retrospectively reviewed. Reconstruction-related complications such as infection, seroma, haematoma, delayed wound healing, and reconstruction failure were recorded. NAC outcome analysis was performed using preoperative and postoperative digital photographs for each patient. Patient satisfaction with the reconstructed breast and NAC was assessed using a study-specific questionnaire.
Results
Delayed wound healing occurred in 18 of 55 NSM patients and 15 of 85 SSM patients (p = 0.040). Final reconstruction failure occurred in 0 NSM patients and 6 SSM patients (p = 0.043). The mean photography analysis score of total aesthetic outcome was 13.12 ± 2.39 in the NSM group and 14.06 ± 2.75 in the SSM group (p = 0.052). The mean questionnaire score of NAC position was 2.88 ± 0.85 in the NSM group and 3.80 ± 0.84 in the SSM group (p = 0.001). The mean questionnaire score of NAC sensitivity was 2.12 ± 0.58 in the NSM group and 1.84 ± 0.46 in the SSM group (p = 0.003). Satisfaction with the reconstructed breast was similar (p = 0.913) after NSM and SSM.
Conclusions
We observed no significant difference in breast reconstruction satisfaction between the NSM and SSM groups. Although overall satisfaction with breast reconstruction is high, patients in the NSM group often report dissatisfaction with nipple position. With a favourable score for NAC position, skin-sparing mastectomy followed by NAC reconstruction can be considered as a balanced alternative to NSM for properly selected patients with breast cancer.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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Knowledge and experience of Family Health Team professionals in providing healthcare for deaf people
Conclusion: the relational dimension is fundamental in developing individual therapy plans. From this perspective, the communication barriers that deaf people face can compromise the necessary bonding for healthcare, which may adversely affect early diagnosis, timely treatment, and adherence to required treatment.RESUMO Objetivo: avaliar a comunica ção na perspectiva dos profissionais de Equipes de Saúde da Família para atendimento a pessoas surdas. Métodos: trata-se estudo transversal que abarcou todas as 39 equipes de Unidades de Saúde da Família da zona urbana e rural. Realizou-se um censo e aplicou-se questionários aos profissiona is das Unidades de Saúde da Família (31 médicos, 30 enfermeiros e 27 cirurgiões-dentistas) e quatro farmacêuticos do Núcleo de Apoio à Saúde ...
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Unilateral hearing loss and the use of hearing aid: speech recognition, benefit, self-perception of functional performance and satisfaction
Conclusion: although showing benefits in speech recognition, in silence and in noise, and satisfaction with sound amplification, most subjects with unilateral hearing loss do not effectively use hearing aids.RESUMO Objetivo: investigar o reconhecimento de fala no sil êncio e no ruído de sujeitos com perda auditiva unilateral, sem e com prótese auditiva, e analisar o benefício, autopercepção do desempenho funcional, satisfação e o uso de prótese auditiva nestes sujeitos. Métodos: foram avaliados 11 adultos, com perda auditiva unilateral, do tipo mista ou neurossensorial, de graus leve a severo. O reconhecimento de fala foi avaliado por meio do teste Listas de Sentenças em Português Brasileiro; o desempenho funcional da audição foi avaliado por meio do questionário Speech Spat...
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Cochlear implantation via middle fossa approach – a case report
. (Source: Cochlear Implants International)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gj0Fud
Knowledge and experience of Family Health Team professionals in providing healthcare for deaf people
Conclusion: the relational dimension is fundamental in developing individual therapy plans. From this perspective, the communication barriers that deaf people face can compromise the necessary bonding for healthcare, which may adversely affect early diagnosis, timely treatment, and adherence to required treatment.RESUMO Objetivo: avaliar a comunica ção na perspectiva dos profissionais de Equipes de Saúde da Família para atendimento a pessoas surdas. Métodos: trata-se estudo transversal que abarcou todas as 39 equipes de Unidades de Saúde da Família da zona urbana e rural. Realizou-se um censo e aplicou-se questionários aos profissiona is das Unidades de Saúde da Família (31 médicos, 30 enfermeiros e 27 cirurgiões-dentistas) e quatro farmacêuticos do Núcleo de Apoio à Saúde ...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GmpmpE
Unilateral hearing loss and the use of hearing aid: speech recognition, benefit, self-perception of functional performance and satisfaction
Conclusion: although showing benefits in speech recognition, in silence and in noise, and satisfaction with sound amplification, most subjects with unilateral hearing loss do not effectively use hearing aids.RESUMO Objetivo: investigar o reconhecimento de fala no sil êncio e no ruído de sujeitos com perda auditiva unilateral, sem e com prótese auditiva, e analisar o benefício, autopercepção do desempenho funcional, satisfação e o uso de prótese auditiva nestes sujeitos. Métodos: foram avaliados 11 adultos, com perda auditiva unilateral, do tipo mista ou neurossensorial, de graus leve a severo. O reconhecimento de fala foi avaliado por meio do teste Listas de Sentenças em Português Brasileiro; o desempenho funcional da audição foi avaliado por meio do questionário Speech Spat...
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Cochlear implantation via middle fossa approach – a case report
. (Source: Cochlear Implants International)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gj0Fud
Merck’s Keytruda looks to zoom past Opdivo with fast head and neck cancer review
Source: Fierce Pharma Date: February 11, 2019 Author: Carly Helfand Merck & Co.'s Keytruda is duking it out with Bristol-Myers Squibb's […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IgPtjc
Merck’s Keytruda looks to zoom past Opdivo with fast head and neck cancer review
Source: Fierce Pharma Date: February 11, 2019 Author: Carly Helfand Merck & Co.'s Keytruda is duking it out with Bristol-Myers Squibb's […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IgPtjc
Exposure to indoor endocrine disrupting chemicals and childhood asthma and obesity
Abstract
Background
Indoor air contaminants may act as endocrine‐disrupting chemicals (EDCs). However, to what extent these contaminants affect health is poorly known. We aimed to assess the association between EDCs exposure and asthma, respiratory symptoms and obesity in schoolchildren.
Methods
Data from a cross‐sectional analysis of 815 participants from 20 schools in Porto, Portugal, were analysed. Symptoms were assessed, asthma was defined on lung function, and airway reversibility and body mass index (BMI) were calculated. The concentrations of 13 volatile organic compounds and 2 aldehydes identified as EDCs were measured in 71 classrooms throughout one week. Principal component analysis (PCA) was used to assess the effect of co‐exposure. Associations were estimated by regression coefficients using linear and logistic regression models.
Results
Increased individual and combined EDCs levels were found in classrooms having more children with asthma and obesity. Higher levels of hexane, styrene, cyclohexanone, butylated hydroxytoluene and 2‐butoxyethanol were associated with obesity, and higher levels of cyclohexanone were associated with increased child BMI. Toluene, o‐xylene, m/p‐xylene and ethylbenzene were significantly associated with nasal obstruction. A positive association was found between PC1 and the risk of obese asthma (OR=1.43, 95% CI 1.01, 1.98) and between PC2 and overweight (OR=1.51, 95% CI 1.28, 1.79). PC1 and PC2 were also associated with nasal obstruction, and PC2 was associated with breathing difficulties and lean body mass, although EDCs concentrations were low.
Conclusions
Our findings further support the role of EDCs in asthma and obesity development. Moreover, even low levels of indoor exposure may influence the risk of asthma, respiratory symptoms and obesity.
This article is protected by copyright. All rights reserved.
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Idiopathic non‐histaminergic angioedema: a single‐centre real‐life experience from Italy
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IgPFyW
Effect of Tarcolimus on Skin Microbiome in Atopic Dermatitis
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tfsCdE
Untreated allergic rhinitis is a major risk factor contributing to motorcar accidents
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IgPCmK
Effect of Sex on Group 2 Innate Lymphoid Cells in the Airways of Mild and Severe Asthmatics
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tfsBX8
Merck’s Keytruda looks to zoom past Opdivo with fast head and neck cancer review
Source: Fierce Pharma Date: February 11, 2019 Author: Carly Helfand Merck & Co.'s Keytruda is duking it out with Bristol-Myers Squibb's […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IgPtjc
Exposure to indoor endocrine disrupting chemicals and childhood asthma and obesity
Abstract
Background
Indoor air contaminants may act as endocrine‐disrupting chemicals (EDCs). However, to what extent these contaminants affect health is poorly known. We aimed to assess the association between EDCs exposure and asthma, respiratory symptoms and obesity in schoolchildren.
Methods
Data from a cross‐sectional analysis of 815 participants from 20 schools in Porto, Portugal, were analysed. Symptoms were assessed, asthma was defined on lung function, and airway reversibility and body mass index (BMI) were calculated. The concentrations of 13 volatile organic compounds and 2 aldehydes identified as EDCs were measured in 71 classrooms throughout one week. Principal component analysis (PCA) was used to assess the effect of co‐exposure. Associations were estimated by regression coefficients using linear and logistic regression models.
Results
Increased individual and combined EDCs levels were found in classrooms having more children with asthma and obesity. Higher levels of hexane, styrene, cyclohexanone, butylated hydroxytoluene and 2‐butoxyethanol were associated with obesity, and higher levels of cyclohexanone were associated with increased child BMI. Toluene, o‐xylene, m/p‐xylene and ethylbenzene were significantly associated with nasal obstruction. A positive association was found between PC1 and the risk of obese asthma (OR=1.43, 95% CI 1.01, 1.98) and between PC2 and overweight (OR=1.51, 95% CI 1.28, 1.79). PC1 and PC2 were also associated with nasal obstruction, and PC2 was associated with breathing difficulties and lean body mass, although EDCs concentrations were low.
Conclusions
Our findings further support the role of EDCs in asthma and obesity development. Moreover, even low levels of indoor exposure may influence the risk of asthma, respiratory symptoms and obesity.
This article is protected by copyright. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tgTtGd
Idiopathic non‐histaminergic angioedema: a single‐centre real‐life experience from Italy
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IgPFyW
Effect of Tarcolimus on Skin Microbiome in Atopic Dermatitis
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tfsCdE
Untreated allergic rhinitis is a major risk factor contributing to motorcar accidents
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IgPCmK
Effect of Sex on Group 2 Innate Lymphoid Cells in the Airways of Mild and Severe Asthmatics
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tfsBX8
Merck’s Keytruda looks to zoom past Opdivo with fast head and neck cancer review
Source: Fierce Pharma Date: February 11, 2019 Author: Carly Helfand Merck & Co.'s Keytruda is duking it out with Bristol-Myers Squibb's […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IgPtjc
Prospective Study to Identify Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in Patients With Elevated Total Serum IgE Levels and Atopic Dermatitis
Conditions: Milk Allergy; Peanut Allergy Interventions: Other: Peanut flour and Oat flour (placebo for peanut flour); Other: Dry Milk Powder and Corn Starch (placebo for Milk powder); Other: Baked milk and Rice milk (placebo for Baked milk) Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health Clinical Center (CC) Recruiting (Source: ClinicalTrials.gov)
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Combination Therapy With VRC-HIVMAB060-00-AB (VRC01) and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions
Condition: HIV Interventions: Biological: VRC-HIVMAB060-00-AB (VRC01); Biological: 10-1074; Biological: Normal Saline Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2StBifu
Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet
Conditions: Intervention; Food Allergy; Food Preferences; Food Intolerance; Diet Habit; Diet Modification Intervention: Behavioral: Multicomponent intervention Sponsors: University Rovira i Virgili; Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)
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Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Conditions: Pulmonary Invasive Mold Infections; Pulmonary Invasive Aspergillosis Intervention: Diagnostic Test: Non-Invasive Testing for PIMI Sponsors: Duke University; Children's Hospital of Philadelphia; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population
Conditions: Hepatitis E; Immunisation Interventions: Biological: HEV 239; Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DubghS
Allergy UK Research and Development Nurse Project
Condition: Allergy Intervention: Other: Nurse Led Allergy Clinic Sponsors: University of Edinburgh; Allergy UK Recruiting (Source: ClinicalTrials.gov)
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Retrospective Chart Review of Candida Fungemia
Condition: Candida Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DufhTr
Prospective Study to Identify Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in Patients With Elevated Total Serum IgE Levels and Atopic Dermatitis
Conditions: Milk Allergy; Peanut Allergy Interventions: Other: Peanut flour and Oat flour (placebo for peanut flour); Other: Dry Milk Powder and Corn Starch (placebo for Milk powder); Other: Baked milk and Rice milk (placebo for Baked milk) Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health Clinical Center (CC) Recruiting (Source: ClinicalTrials.gov)
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DupK1h
Combination Therapy With VRC-HIVMAB060-00-AB (VRC01) and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions
Condition: HIV Interventions: Biological: VRC-HIVMAB060-00-AB (VRC01); Biological: 10-1074; Biological: Normal Saline Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2StBifu
Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet
Conditions: Intervention; Food Allergy; Food Preferences; Food Intolerance; Diet Habit; Diet Modification Intervention: Behavioral: Multicomponent intervention Sponsors: University Rovira i Virgili; Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dt1Bbh
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Conditions: Pulmonary Invasive Mold Infections; Pulmonary Invasive Aspergillosis Intervention: Diagnostic Test: Non-Invasive Testing for PIMI Sponsors: Duke University; Children's Hospital of Philadelphia; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sp4tjU
Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population
Conditions: Hepatitis E; Immunisation Interventions: Biological: HEV 239; Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DubghS
Allergy UK Research and Development Nurse Project
Condition: Allergy Intervention: Other: Nurse Led Allergy Clinic Sponsors: University of Edinburgh; Allergy UK Recruiting (Source: ClinicalTrials.gov)
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Retrospective Chart Review of Candida Fungemia
Condition: Candida Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DufhTr
Parental asthma and risk of autism spectrum disorder in offspring: a population and family based case‐control study
Abstract
Background
Associations between parental asthma and prenatal exposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported. However, the associations might be confounded by unmeasured (genetic and shared environmental) familial factors.
Objective
We investigated the association between (a) maternal/paternal asthma and offspring ASD, and (b) prenatal exposures to β2‐agonists, other asthma medications and offspring ASD using cases and controls selected from the population as well as biological relatives with different degrees of relatedness.
Methods
We included all children (N=1,579,263) born in Sweden 1992‐2007. A nested case‐control design was used to compare 22,894 ASD cases identified from the National Patient Register to (i) 228,940 age‐, county‐ and sex‐matched controls randomly selected from the population, (ii) their eligible full‐siblings (n=1,267), (iii) half‐siblings (n=1,323), (iv) full‐cousins (n=11,477), and (v) half‐cousins (n=3,337). Conditional logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for ASD in children differentially exposed to parental asthma or prenatal asthma medications.
Results
Maternal asthma was associated with increased risk of offspring ASD (OR 1.43, 95% CI 1.38‐1.49); there was a weaker association for paternal asthma (OR 1.17, 95% CI 1.11‐1.23). The risk of offspring ASD in mothers with asthma showed similar estimates when adjusting for shared familial factors among paternal half‐siblings (OR 1.20, 95% CI 0.80‐1.81), full‐cousins (OR 1.28, 95% CI 1.16‐1.41), and half‐cousins (OR 1.30, 95% CI 1.10‐1.54), albeit with wider confidence intervals. Prenatal exposure to asthma medications among subjects whose mothers had asthma was not associated with subsequent ASD.
Conclusions and clinical relevance
In this large observational study, parental asthma was associated with slightly elevated risk of ASD in offspring. More specifically, the increased risk by maternal asthma did not seem to be confounded by familial factors. There was no evidence of an association between asthma medications during pregnancy and offspring ASD.
This article is protected by copyright. All rights reserved.
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Parental asthma and risk of autism spectrum disorder in offspring: a population and family based case‐control study
Abstract
Background
Associations between parental asthma and prenatal exposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported. However, the associations might be confounded by unmeasured (genetic and shared environmental) familial factors.
Objective
We investigated the association between (a) maternal/paternal asthma and offspring ASD, and (b) prenatal exposures to β2‐agonists, other asthma medications and offspring ASD using cases and controls selected from the population as well as biological relatives with different degrees of relatedness.
Methods
We included all children (N=1,579,263) born in Sweden 1992‐2007. A nested case‐control design was used to compare 22,894 ASD cases identified from the National Patient Register to (i) 228,940 age‐, county‐ and sex‐matched controls randomly selected from the population, (ii) their eligible full‐siblings (n=1,267), (iii) half‐siblings (n=1,323), (iv) full‐cousins (n=11,477), and (v) half‐cousins (n=3,337). Conditional logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for ASD in children differentially exposed to parental asthma or prenatal asthma medications.
Results
Maternal asthma was associated with increased risk of offspring ASD (OR 1.43, 95% CI 1.38‐1.49); there was a weaker association for paternal asthma (OR 1.17, 95% CI 1.11‐1.23). The risk of offspring ASD in mothers with asthma showed similar estimates when adjusting for shared familial factors among paternal half‐siblings (OR 1.20, 95% CI 0.80‐1.81), full‐cousins (OR 1.28, 95% CI 1.16‐1.41), and half‐cousins (OR 1.30, 95% CI 1.10‐1.54), albeit with wider confidence intervals. Prenatal exposure to asthma medications among subjects whose mothers had asthma was not associated with subsequent ASD.
Conclusions and clinical relevance
In this large observational study, parental asthma was associated with slightly elevated risk of ASD in offspring. More specifically, the increased risk by maternal asthma did not seem to be confounded by familial factors. There was no evidence of an association between asthma medications during pregnancy and offspring ASD.
This article is protected by copyright. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UU3Yew
The Tooth Crossing the Confinement of Mandible: An Unique Expression of Central Variety of Dentigerous Cyst
We report a case of a 28 years old male diagnosed with an impacted mandibular third molar associated with DC and its surgical management. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DyUFcG
The Tooth Crossing the Confinement of Mandible: An Unique Expression of Central Variety of Dentigerous Cyst
We report a case of a 28 years old male diagnosed with an impacted mandibular third molar associated with DC and its surgical management. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DyUFcG
Macropinosomes as Units of Signal Transduction
Date: Tuesday, 02 19, 2019; Speaker: Joel A. Swanson, Professor, University of Michigan, Microbiology& Immunology; 5625 Fishers Lane; 5th Floor (Source: NIH Calendar of Events)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Buql2U
Macropinosomes as Units of Signal Transduction
Date: Tuesday, 02 19, 2019; Speaker: Joel A. Swanson, Professor, University of Michigan, Microbiology& Immunology; 5625 Fishers Lane; 5th Floor (Source: NIH Calendar of Events)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Buql2U
Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic mu...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RQP1rL
Ethnobotanical knowledge among the semi-pastoral Gujjar tribe in the high altitude (Adhwari’s) of Churah subdivision, district Chamba, Western Himalaya
The wild plants not only form an integral part of the culture and traditions of the Himalayan tribal communities but also contribute largely to the sustenance of these communities. The tribal people use large ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2URggEf
Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic mu...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RQP1rL
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