Improving efficacy of cancer immunotherapy through targeting of macrophages

. (Source: Human Vaccines and Immunotherapeutics)

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Gallic acid attenuates allergic airway inflammation via suppressed interleukin ‐33 and group 2 innate lymphoid cells in ovalbumin‐induced asthma in mice

International Forum of Allergy&Rhinology, EarlyView. (Source: International Forum of Allergy and Rhinology)

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The immunomodulatory role of probiotics in allergy therapy

Journal of Cellular Physiology, EarlyView. (Source: Journal of Cellular Physiology)

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Study: HPV cancer survivors at risk for second HPV cancer

Source: www.bcm.edu Author: Dipali Pathak A retrospective study led by researchers at Baylor College of Medicine and The University of Texas […]

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Natural remedies for eye allergies

(Natural News) In the U.S., more than 50 million people suffer from allergies, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Fortunately, allergies can be treated without the use of drug medications. Here are natural remedies available for allergies, particularly eye allergy: (h/t: Homeo-Pathic.esy.es) Prepare either a warm or cold compress: A... (Source: NaturalNews.com)

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Study: HPV cancer survivors at risk for second HPV cancer

Source: www.bcm.edu Author: Dipali Pathak A retrospective study led by researchers at Baylor College of Medicine and The University of Texas […]

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Natural remedies for eye allergies

(Natural News) In the U.S., more than 50 million people suffer from allergies, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Fortunately, allergies can be treated without the use of drug medications. Here are natural remedies available for allergies, particularly eye allergy: (h/t: Homeo-Pathic.esy.es) Prepare either a warm or cold compress: A... (Source: NaturalNews.com)

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Study: HPV cancer survivors at risk for second HPV cancer

Source: www.bcm.edu Author: Dipali Pathak A retrospective study led by researchers at Baylor College of Medicine and The University of Texas […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NqP1jR

Study: HPV cancer survivors at risk for second HPV cancer

Source: www.bcm.edu Author: Dipali Pathak A retrospective study led by researchers at Baylor College of Medicine and The University of Texas […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NqP1jR

Natural remedies for eye allergies

(Natural News) In the U.S., more than 50 million people suffer from allergies, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Fortunately, allergies can be treated without the use of drug medications. Here are natural remedies available for allergies, particularly eye allergy: (h/t: Homeo-Pathic.esy.es) Prepare either a warm or cold compress: A... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CuR3v4

Natural remedies for eye allergies

(Natural News) In the U.S., more than 50 million people suffer from allergies, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Fortunately, allergies can be treated without the use of drug medications. Here are natural remedies available for allergies, particularly eye allergy: (h/t: Homeo-Pathic.esy.es) Prepare either a warm or cold compress: A... (Source: NaturalNews.com)

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Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy.

CONCLUSION: Patients with cefaclor anaphylaxis exhibit high serum IgE levels. A cut-off value of 0.11 kU/L of sIgE to cefaclor is proper for identifying patients with cefaclor allergy, and 0.44 kU/L may be useful to detect anaphylaxis. PMID: 30187704 [PubMed - in process] (Source: Yonsei Medical Journal)

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Cervical lymphadenopathy: can the histogram analysis of apparent diffusion coefficient help to differentiate between lymphoma and squamous cell carcinoma in patients with unknown clinical primary tumor?

Abstract

Purpose

To retrospectively evaluate the value of whole-lesion histogram analysis of apparent diffusion coefficient (ADC) maps in differentiating between lymphoma and metastatic squamous cell carcinoma (SCC) of unknown clinical primary in neck nodes.

Methods

A total of 39 patients, 20 affected by lymphoma and 19 affected by metastatic non-nasopharyngeal SCC, were included in this retrospective study. All patients underwent MR imaging with a 1.5 T scanner system, including diffusion-weighted imaging (DWI) with three different b values (b = 0, 500 and 800 s/mm²). The entire tumor volume was manually delineated on the ADC maps, using the T2-weighted images and DWIs with b = 800 s/mm² as a guide to the lesion location. The Mann–Whitney rank-sum test for independent samples was performed to compare the histogram parameters of patients with lymphoma and SCC.

Results

The SCCs showed significantly higher median ADC (ADC_median) and mean ADC (ADC_mean) values, compared to lymphomas (p < 0.001), while they exhibited lower kurtosis and skewness without reaching significance (p = 0.066 and 0.148, respectively). The ADC_mean and ADC_median had the best discriminative powers for differentiating lymphoma and SCC, with an area under the curve of 87% and 85%, respectively. The optimal cutoff values for ADC_mean and ADC_median as predictors for lymphoma were ≤ 0.83 × 10⁻³ mm²/s and ≤ 0.73 × 10⁻³ mm²/s, respectively.

Conclusions

The whole-lesion ADC histogram analysis of cervical lymphadenopathy may help to discriminate lymphomas from non-nasopharyngeal SCC in patients with unknown clinical primary tumor.

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Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy.

CONCLUSION: Patients with cefaclor anaphylaxis exhibit high serum IgE levels. A cut-off value of 0.11 kU/L of sIgE to cefaclor is proper for identifying patients with cefaclor allergy, and 0.44 kU/L may be useful to detect anaphylaxis. PMID: 30187704 [PubMed - in process] (Source: Yonsei Medical Journal)

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Cervical lymphadenopathy: can the histogram analysis of apparent diffusion coefficient help to differentiate between lymphoma and squamous cell carcinoma in patients with unknown clinical primary tumor?

Abstract

Purpose

To retrospectively evaluate the value of whole-lesion histogram analysis of apparent diffusion coefficient (ADC) maps in differentiating between lymphoma and metastatic squamous cell carcinoma (SCC) of unknown clinical primary in neck nodes.

Methods

A total of 39 patients, 20 affected by lymphoma and 19 affected by metastatic non-nasopharyngeal SCC, were included in this retrospective study. All patients underwent MR imaging with a 1.5 T scanner system, including diffusion-weighted imaging (DWI) with three different b values (b = 0, 500 and 800 s/mm²). The entire tumor volume was manually delineated on the ADC maps, using the T2-weighted images and DWIs with b = 800 s/mm² as a guide to the lesion location. The Mann–Whitney rank-sum test for independent samples was performed to compare the histogram parameters of patients with lymphoma and SCC.

Results

The SCCs showed significantly higher median ADC (ADC_median) and mean ADC (ADC_mean) values, compared to lymphomas (p < 0.001), while they exhibited lower kurtosis and skewness without reaching significance (p = 0.066 and 0.148, respectively). The ADC_mean and ADC_median had the best discriminative powers for differentiating lymphoma and SCC, with an area under the curve of 87% and 85%, respectively. The optimal cutoff values for ADC_mean and ADC_median as predictors for lymphoma were ≤ 0.83 × 10⁻³ mm²/s and ≤ 0.73 × 10⁻³ mm²/s, respectively.

Conclusions

The whole-lesion ADC histogram analysis of cervical lymphadenopathy may help to discriminate lymphomas from non-nasopharyngeal SCC in patients with unknown clinical primary tumor.

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Use of 5% monoethanolamine oleate foam in oral varicose

Publication date: Available online 7 September 2018

Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Author(s): Camila de Nazaré Alves de Oliveira Kato, Márcio Bruno Figueiredo do Amaral, Wagner Henriques de Castro, Ricardo Santiago Gomez, Ricardo Alves Mesquita

Abstract

Objective

Oral varicose is an acquired change that occurs in the veins. Usually, small oral varicose require no treatment. Aesthetic site, trauma and bleeding risk of the lesion need of intervention. This technical note describes the treatment of oral varicose by sclerotherapy in form of foam.

Method

The 5% monoethanolamine oleate was used. The foam was produced with Tessari method, in which the proportion air:liquid sclerosing was 4:1. A single application of the 0.5 mL of foam was made under local anesthesia.

Result

Signs and symptoms were minimal after the treatment. Clinical remission of the lesion was observed in two weeks.

Conclusion

The 5% monoethanolamine oleate foam showed to be effective and safety for treatment this case of the oral varicose.

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Use of 5% monoethanolamine oleate foam in oral varicose

Publication date: Available online 7 September 2018

Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Author(s): Camila de Nazaré Alves de Oliveira Kato, Márcio Bruno Figueiredo do Amaral, Wagner Henriques de Castro, Ricardo Santiago Gomez, Ricardo Alves Mesquita

Abstract

Objective

Oral varicose is an acquired change that occurs in the veins. Usually, small oral varicose require no treatment. Aesthetic site, trauma and bleeding risk of the lesion need of intervention. This technical note describes the treatment of oral varicose by sclerotherapy in form of foam.

Method

The 5% monoethanolamine oleate was used. The foam was produced with Tessari method, in which the proportion air:liquid sclerosing was 4:1. A single application of the 0.5 mL of foam was made under local anesthesia.

Result

Signs and symptoms were minimal after the treatment. Clinical remission of the lesion was observed in two weeks.

Conclusion

The 5% monoethanolamine oleate foam showed to be effective and safety for treatment this case of the oral varicose.

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Salivary Proteome patterns of individuals exposed to High Altitude

Publication date: Available online 7 September 2018

Source: Archives of Oral Biology

Author(s): Shikha Jain, Yasmin Ahmad, Kalpana Bhargava

Abstract

Objective

Identification of molecular signatures having key roles in hypobaric hypoxia by analysing the salivary proteome. Saliva holds a promising future in the search for new clinical biomarkers that are easily accessible, less complex, accurate, and cost effective as well as being non-invasive.

Methodology

We employed qualitative proteomics approach to develop discriminatory biomarker signatures from human saliva exposed to hypobaric hypoxia. Salivary proteins were analyzed and compared between age-matched healthy subjects exposed to high altitude (~13700 ft) for seven days (HAD7) with control subjects at sea level (Normoxia) by using 2-Dimensional gel electrophoresis/Mass Spectrometry approach.

Results

Several proteins with significant differential expression were found. The up-regulated proteins were apoptosis inducing factor-2, cystatin S, cystatin SN and carbonic anhydrase 6. The down regulated proteins were polymeric immunoglobulin receptor, alpha-enolase and prolactin-inducible protein. Further confirmation of the altered proteins such as alpha enolase, carbonic anhydrase 6, prolactin-inducible protein, apoptosis inducing factor 2, cystatin S and cystatin SN was performed using immunoblotting. The expression patterns of the selected proteins observed by immunoblot were in concurrence with 2-Dimesional gel electrophoresis results, therefore affirming the authenticity of the proteomic investigation.

Conclusion

This study provides the proof of concept of salivary biomarkers for the non-invasive detection of hypobaric hypoxia induced effects. It is highly feasible to turn these biomarkers into an applicable clinical test after large scale validation.

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Salivary Proteome patterns of individuals exposed to High Altitude

Publication date: Available online 7 September 2018

Source: Archives of Oral Biology

Author(s): Shikha Jain, Yasmin Ahmad, Kalpana Bhargava

Abstract

Objective

Identification of molecular signatures having key roles in hypobaric hypoxia by analysing the salivary proteome. Saliva holds a promising future in the search for new clinical biomarkers that are easily accessible, less complex, accurate, and cost effective as well as being non-invasive.

Methodology

We employed qualitative proteomics approach to develop discriminatory biomarker signatures from human saliva exposed to hypobaric hypoxia. Salivary proteins were analyzed and compared between age-matched healthy subjects exposed to high altitude (~13700 ft) for seven days (HAD7) with control subjects at sea level (Normoxia) by using 2-Dimensional gel electrophoresis/Mass Spectrometry approach.

Results

Several proteins with significant differential expression were found. The up-regulated proteins were apoptosis inducing factor-2, cystatin S, cystatin SN and carbonic anhydrase 6. The down regulated proteins were polymeric immunoglobulin receptor, alpha-enolase and prolactin-inducible protein. Further confirmation of the altered proteins such as alpha enolase, carbonic anhydrase 6, prolactin-inducible protein, apoptosis inducing factor 2, cystatin S and cystatin SN was performed using immunoblotting. The expression patterns of the selected proteins observed by immunoblot were in concurrence with 2-Dimesional gel electrophoresis results, therefore affirming the authenticity of the proteomic investigation.

Conclusion

This study provides the proof of concept of salivary biomarkers for the non-invasive detection of hypobaric hypoxia induced effects. It is highly feasible to turn these biomarkers into an applicable clinical test after large scale validation.

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Vancomycin-resistant Enterococcus faecium at a university hospital in Taiwan, 2002–2015: Fluctuation of genetic populations and emergence of a new structure type of the Tn1546-like element

ConclusionDissemination of some major STs and horizontal transfer of plasmids carrying two major structure types of Tn1546-like elements may have together contributed to the increase of VRE-fm infection. (Source: Journal of Microbiology, Immunology and Infection)

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