Condition: Sensorineural Hearing Loss, Bilateral Intervention: Device: FineHearing strategy Sponsor: Med-El Elektromedizinische Geraete GmbH Not yet recruiting (Source: ClinicalTrials.gov)
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Κυριακή 7 Οκτωβρίου 2018
Study of Auditory Performance on Prosodic Tests in Cochlear Implanted Subjects Using a Fine Structure Strategy
Optimization of Cochlear Implant MAP-parameters in Children
Conditions: Cochlear Implants; Evoked Potentials, Auditory; Child; Disabilities Hearing; Deafness; Hearing Intervention: Other: Re-programming of cochlear implant Sponsors: Göteborg University; Vastra Gotaland Region Not yet recruiting (Source: ClinicalTrials.gov)
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Optimization of Cochlear Implant MAP-parameters in Children
Conditions: Cochlear Implants; Evoked Potentials, Auditory; Child; Disabilities Hearing; Deafness; Hearing Intervention: Other: Re-programming of cochlear implant Sponsors: Göteborg University; Vastra Gotaland Region Not yet recruiting (Source: ClinicalTrials.gov)
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Study of Auditory Performance on Prosodic Tests in Cochlear Implanted Subjects Using a Fine Structure Strategy
Condition: Sensorineural Hearing Loss, Bilateral Intervention: Device: FineHearing strategy Sponsor: Med-El Elektromedizinische Geraete GmbH Not yet recruiting (Source: ClinicalTrials.gov)
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Study of Auditory Performance on Prosodic Tests in Cochlear Implanted Subjects Using a Fine Structure Strategy
Condition: Sensorineural Hearing Loss, Bilateral Intervention: Device: FineHearing strategy Sponsor: Med-El Elektromedizinische Geraete GmbH Not yet recruiting (Source: ClinicalTrials.gov)
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Optimization of Cochlear Implant MAP-parameters in Children
Conditions: Cochlear Implants; Evoked Potentials, Auditory; Child; Disabilities Hearing; Deafness; Hearing Intervention: Other: Re-programming of cochlear implant Sponsors: Göteborg University; Vastra Gotaland Region Not yet recruiting (Source: ClinicalTrials.gov)
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FLUAD vs. FLUZONE HD Influenza Vaccine in Residents of Long Term Care
Condition: Flu Interventions: Drug: Fluad Vaccine; Drug: Fluzone HD Vaccine Sponsors: David H. Canaday; Case Western Reserve University; US Department of Veterans Affairs; Brown University; National Institutes of Health (NIH); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Food Allergy Diagnostic Test Response to Previous Oral Challenge Response
Condition: Food Hypersensitivity Intervention: Other: Conjunctival Allergen Challenge Sponsor: ORA, Inc. Completed (Source: ClinicalTrials.gov)
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FLUAD vs. FLUZONE HD Influenza Vaccine in Residents of Long Term Care
Condition: Flu Interventions: Drug: Fluad Vaccine; Drug: Fluzone HD Vaccine Sponsors: David H. Canaday; Case Western Reserve University; US Department of Veterans Affairs; Brown University; National Institutes of Health (NIH); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Food Allergy Diagnostic Test Response to Previous Oral Challenge Response
Condition: Food Hypersensitivity Intervention: Other: Conjunctival Allergen Challenge Sponsor: ORA, Inc. Completed (Source: ClinicalTrials.gov)
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Implementing a Software Solution across Multiple Ultrasound Vendors to Auto-fill Reports with Measurement Values
Publication date: Available online 7 October 2018
Source: Current Problems in Diagnostic Radiology
Author(s): Meir H Scheinfeld, Oleg Kaplun, Neville A Simmons, Jonathan Sterman, Shlomit Goldberg-Stein
Abstract
Reliable transmission of ultrasound measurements into radiology reports is fraught with potential sources of error. In a conventional workflow, measurements are either written by hand on worksheets and/or dictated from worksheets or the images themselves into the radiology report. Valuable physician time is spent dictating, checking and editing these values and this process is error-prone. Our approach was to use a transfer-software application to auto-populate measurements, with a goal of achieving >90% utilization rate by both technologists and radiologists. Implementation involved creating measurement fields for each measurement on each ultrasound unit of our multi-site academic department. These fields were then mapped in both the transfer-software and the dictation software, to set up a 1:1:1 correspondence for each field. As a result, each measurement acquired by the technologist would automatically populate the radiology report within the dictation software. We created and mapped 128 fields for 39 exam templates. After implementation, technologist utilization rate was 86-96% and overall radiologist utilization rate was 92-93%. Radiology resident utilization rate was highest, at 95-96%. We provide a guide for implementation and lessons learned.
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Case report on recovery from Japanese encephalitis virus infection by complementary use of phytolacca-mother tincture and in silico analysis
Publication date: Available online 6 October 2018
Source: Journal of Herbal Medicine
Author(s): Harish Chandra Chaudhury, Akhil Kumar Panda, Sarat Kumar Behera, Manjushree Mohanty, Bharat Bhusan Subudhi
Abstract
Phytolacca Americana L
or pokeweed has medicinal application against inflammation, arthritis, and viral fever infections in traditional medicines. Its mother tincture in the homeopathic system of medicine is used for many of these disease conditions. This is the first case study reporting the beneficial effects of Phytolacca-mother tincture against Japanese Encephalitis Virus (JEV) infection in an intensive care unit (ICU) patient. A 42-year-old male patient with JEV infection failed to respond to conventional therapy. Following this, he was administered pokeweed tincture orally, two drops three times daily along with conventional therapy. Gradually the patient recovered and after two months of treatment, the patient was discharged with neurological sequelae. The anti-JEV basis of pokeweed was investigated by in silico analysis. The antiviral protein of pokeweed which has earlier been reported to inhibit viral RNA synthesis was shown to have the affinity for nonstructural protein (NS5) of JEV by use of protein-protein docking. Esculentic acid of pokeweed was also predicted to have a strong affinity for NS3 and NS5 of JEV. It was also found to be a potent inhibitor of multiple targets which have the potential to mediate antiviral action. Considering the possibilities of both direct and indirect interferences of pokeweed phytoconstituents with JEV proteins, it can be suggested that pokeweed mother tincture can be a good complementary antiviral therapy against JEV infection.
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Implementing a Software Solution across Multiple Ultrasound Vendors to Auto-fill Reports with Measurement Values
Publication date: Available online 7 October 2018
Source: Current Problems in Diagnostic Radiology
Author(s): Meir H Scheinfeld, Oleg Kaplun, Neville A Simmons, Jonathan Sterman, Shlomit Goldberg-Stein
Abstract
Reliable transmission of ultrasound measurements into radiology reports is fraught with potential sources of error. In a conventional workflow, measurements are either written by hand on worksheets and/or dictated from worksheets or the images themselves into the radiology report. Valuable physician time is spent dictating, checking and editing these values and this process is error-prone. Our approach was to use a transfer-software application to auto-populate measurements, with a goal of achieving >90% utilization rate by both technologists and radiologists. Implementation involved creating measurement fields for each measurement on each ultrasound unit of our multi-site academic department. These fields were then mapped in both the transfer-software and the dictation software, to set up a 1:1:1 correspondence for each field. As a result, each measurement acquired by the technologist would automatically populate the radiology report within the dictation software. We created and mapped 128 fields for 39 exam templates. After implementation, technologist utilization rate was 86-96% and overall radiologist utilization rate was 92-93%. Radiology resident utilization rate was highest, at 95-96%. We provide a guide for implementation and lessons learned.
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Case report on recovery from Japanese encephalitis virus infection by complementary use of phytolacca-mother tincture and in silico analysis
Publication date: Available online 6 October 2018
Source: Journal of Herbal Medicine
Author(s): Harish Chandra Chaudhury, Akhil Kumar Panda, Sarat Kumar Behera, Manjushree Mohanty, Bharat Bhusan Subudhi
Abstract
Phytolacca Americana L
or pokeweed has medicinal application against inflammation, arthritis, and viral fever infections in traditional medicines. Its mother tincture in the homeopathic system of medicine is used for many of these disease conditions. This is the first case study reporting the beneficial effects of Phytolacca-mother tincture against Japanese Encephalitis Virus (JEV) infection in an intensive care unit (ICU) patient. A 42-year-old male patient with JEV infection failed to respond to conventional therapy. Following this, he was administered pokeweed tincture orally, two drops three times daily along with conventional therapy. Gradually the patient recovered and after two months of treatment, the patient was discharged with neurological sequelae. The anti-JEV basis of pokeweed was investigated by in silico analysis. The antiviral protein of pokeweed which has earlier been reported to inhibit viral RNA synthesis was shown to have the affinity for nonstructural protein (NS5) of JEV by use of protein-protein docking. Esculentic acid of pokeweed was also predicted to have a strong affinity for NS3 and NS5 of JEV. It was also found to be a potent inhibitor of multiple targets which have the potential to mediate antiviral action. Considering the possibilities of both direct and indirect interferences of pokeweed phytoconstituents with JEV proteins, it can be suggested that pokeweed mother tincture can be a good complementary antiviral therapy against JEV infection.
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γδ T cells amplify Blomia tropicalis‐induced allergic airway disease
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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Legends of Allergy: Carla Bruijnzeel ‐Koomen
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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γδ T cells amplify Blomia tropicalis‐induced allergic airway disease
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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Legends of Allergy: Carla Bruijnzeel ‐Koomen
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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Effects of intraarticular tramadol, magnesium and ketamine on postoperative pain in arthroscopic meniscectomy
Publication date: Available online 6 October 2018
Source: Brazilian Journal of Anesthesiology (English Edition)
Author(s): Nevriye Salman, Bilge Olgunkeleş, Umut Bektaş, Derviş Güner, Meltem Bektas, Şadan Ay, Sumru Şekerci
Abstract
Objective
Postoperative pain control is important in terms of early recovery and rehabilitation in arthroscopic meniscectomy. For this purpose, we aimed to compare the effects of intraarticular tramadol, magnesium, and ketamine with combinations of pericapsular bupivacaine on postoperative pain and recovery in arthroscopic meniscectomy.
Methods
Ninety patients who underwent arthroscopic meniscectomy were enrolled in the study. Group T was given tramadol, Group K was given ketamine, and Group M was given magnesium reconstituted intraarticularly, and all groups received periarticular bupivacaine. Comparisons were made in terms of the patients' postoperative Visual Analogue Scale scores with and without movement, need for additional analgesics, first analgesic time, mobilization times, adverse effects, and satisfaction with the analgesics.
Results
The Visual Analogue Scale scores were lowest in Group T at 0 minutes, and were higher in the 15th and 30th minutes and 1st, 2nd, and 6th hours. Visual Analogue Scale values with movement were found to be high in Group M at 0 and 15 minutes, but they were found to be higher in group T in the 30th minute, 1st, 2nd and 6th hour. The groups were similar in terms of postoperative additional analgesic use, number of analgesic use, and satisfaction with analgesics; however, the first analgesic time was earlier in Group M, and the first mobilization time was earlier in Group K.
Conclusion
Intraarticular ketamine enables early mobilization and less need for additional analgesics, it also provides a better analgesic effect in comparison with intraarticular tramadol and magnesium.
Resumo
Objetivo
O controle da dor pós-operatória é importante para recuperação e reabilitação precoces em meniscectomia artroscópica. Portanto, nosso objetivo foi comparar os efeitos de tramadol, magnésio e cetamina administrados por via intra-articular em associação com bupivacaína pericapsular sobre a dor e a recuperação após meniscectomia artroscópica.
Métodos
Noventa pacientes submetidos à meniscectomia artroscópica foram incluídos no estudo. O Grupo T recebeu tramadol, o Grupo K recebeu cetamina e o Grupo M recebeu magnésio em doses reconstituídas por via intra-articular e todos os grupos receberam bupivacaína por via periarticular. As avaliações foram feitas mediante comparação dos escores em escala visual analógica no pós-operatório dos pacientes em movimento e em repouso, necessidade de analgésicos adicionais, tempo até a primeira necessidade de analgésico, tempo de mobilização, efeitos adversos e satisfação com os analgésicos.
Resultados
Os escores da escala visual analógica foram menores no minuto zero e maiores nos minutos 15 e 30 e nas horas 1, 2 e 6 no Grupo T. Os escores da escala visual analógica em movimento foram maiores nos minutos zero e 15 no Grupo M e maiores no minuto 30 e nas horas 1, 2 e 6 no Grupo T. Os escores dos grupos foram semelhantes em relação à necessidade de analgésico adicional no pós-operatório, ao consumo de analgésico e à satisfação com os analgésicos, mas os tempos até a primeira necessidade de analgesia e até a primeira mobilização foram mais curtos nos grupos M e K, respectivamente.
Conclusão
A administração intra-articular de cetamina permite mobilização precoce e diminui a necessidade de analgésicos adicionais, além de proporcionar um melhor efeito analgésico em comparação com tramadol e magnésio por via intra-articular.
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Transthoracic echocardiographic assessment of cardiac output in mechanically ventilated critically ill patients by intensive care unit physicians
Publication date: Available online 6 October 2018
Source: Brazilian Journal of Anesthesiology (English Edition)
Author(s): Valentina Bergamaschi, Gian Luca Vignazia, Antonio Messina, Davide Colombo, Gianmaria Cammarota, Francesco Della Corte, Egidio Traversi, Paolo Navalesi
Abstract
Background and objectives
Transthoracic echocardiography may potentially be useful to obtain a prompt, accurate and non-invasive estimation of cardiac output. We evaluated whether non-cardiologist intensivists may obtain accurate and reproducible cardiac output determination in hemodynamically unstable mechanically ventilated patients.
Methods
We studied 25 hemodynamically unstable mechanically ventilated intensive care unit patients with a pulmonary artery catheter in place. Cardiac output was calculated using the pulsed Doppler transthoracic echocardiography technique applied to the left ventricular outflow tract in apical 5 chamber view by two intensive care unit physicians who had received a basic Transthoracic Echocardiography training plus a specific training focused on Doppler, left ventricular outflow tract and velocity-time integral determination.
Results
Cardiac output assessment by transthoracic echocardiography was feasible in 20 out of 25 enrolled patients (80%) and showed an excellent inter-operator reproducibility (Pearson correlation test r = 0.987; Cohen's K = 0.840). Overall, the mean bias was 0.03 L.min−1, with limits of agreement −0.52 and +0.57 L.min−1. The concordance correlation coefficient (ρc) was 0.986 (95% IC 0.966–0.995) and 0.995 (95% IC 0.986–0.998) for physician 1 and 2, respectively. The value of accuracy (Cb) of COTTE measurement was 0.999 for both observers. The value of precision (ρ) of COTTE measurement was 0.986 and 0.995 for observer 1 and 2, respectively.
Conclusions
A specific training focused on Doppler and VTI determination added to the standard basic transthoracic echocardiography training allowed non-cardiologist intensive care unit physicians to achieve a quick, reproducible and accurate snapshot cardiac output assessment in the majority of mechanically ventilated intensive care unit patients.
Resumo
Justificativa e objetivos
A ecocardiografia transtorácica pode ser potencialmente útil para obter uma estimativa rápida, precisa e não invasiva do débito cardíaco. Avaliamos se os intensivistas não cardiologistas podem obter uma determinação precisa e reprodutível do débito cardíaco em pacientes mecanicamente ventilados e hemodinamicamente instáveis.
Métodos
Avaliamos 25 pacientes em unidade de terapia intensiva, mecanicamente ventilados, hemodinamicamente instáveis, com cateteres de artéria pulmonar posicionados. O débito cardíaco foi calculado usando a técnica de ecocardiografia transtorácica com Doppler pulsátil aplicada à via de saída do ventrículo esquerdo no corte apical (5-câmaras) por dois médicos intensivistas que receberam treinamento básico em ecocardiografia transtorácica e treinamento específico focado em Doppler, via de saída do ventrículo esquerdo e determinação da integral de tempo-velocidade.
Resultados
A avaliação do débito cardíaco pelo ecocardiograma transtorácico foi factível em 20 dos 25 pacientes inscritos (80%) e mostrou excelente reprodutibilidade entre operadores (teste de correlação de Pearson r = 0,987; K de Cohen = 0,840). No geral, o viés médio foi de 0,03 L.min−1, com limites de concordância de −0,52 e +0,57 L.min−1. O coeficiente de correlação de concordância (ρc) foi 0,986 (95% IC 0,966–0,995) e 0,995 (95% IC 0,986–0,998) para os médicos 1 e 2, respectivamente. O valor de precisão (Cb) da mensuração de COTTE foi de 0,999 para ambos os observadores. O valor de precisão (ρ) da mensuração de COTTE foi de 0,986 e 0,995 para os observadores 1 e 2, respectivamente.
Conclusões
Um treinamento específico focado na determinação do Doppler e VTI, adicionado ao treinamento padrão em ecocardiografia transtorácica básica, permitiu que médicos não cardiologistas da unidade de terapia intensiva obtivessem uma avaliação rápida, reprodutível e precisa do débito cardíaco instantâneo na maioria dos pacientes mecanicamente ventilados em unidade de terapia intensiva.
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