International symposium defines the future role of oral physicians

Abstract

On 7 October 2017, an international forward‐looking symposium for approximately 800 dental personnel entitled "Dentistry in the future ‐ through information from different countries" was held in Sakata, Japan. The contents of the 12^th annual symposium were full of significant indications and suggestions on future healthcare which we think are worth reporting.

This article is protected by copyright. All rights reserved.

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International symposium defines the future role of oral physicians

Abstract

On 7 October 2017, an international forward‐looking symposium for approximately 800 dental personnel entitled "Dentistry in the future ‐ through information from different countries" was held in Sakata, Japan. The contents of the 12^th annual symposium were full of significant indications and suggestions on future healthcare which we think are worth reporting.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ScC7VT

Alteration of FDG uptake by performing novel object recognition task in a rat model of Traumatic Brain Injury

Publication date: March 2019

Source: NeuroImage, Volume 188

Author(s): Shalini Jaiswal, Nicole Hockenbury, Hongna Pan, Andrew Knutsen, Bernard J. Dardzinski, Kimberly R. Byrnes

Abstract

Traumatic Brain Injury (TBI) affects approximately 2.5 million people in the United States, of which 80% are considered to be mild (mTBI). Previous studies have shown that cerebral glucose uptake and metabolism are altered after brain trauma and functional metabolic deficits observed following mTBI are associated with changes in cognitive performance. Imaging of glucose uptake using [¹⁸F] Fluorodeoxyglucose (FDG) based Positron Emission Tomography (PET) with anesthesia during the uptake period demonstrated limited variability in results, but may have depressed uptake. Anesthesia has been found to interfere with blood glucose levels, and hence, FDG uptake. Conversely, forced cognitive testing during uptake may increase glucose demand in targeted regions, such as hippocampus, allowing for better differentiation of outcomes. Therefore, the objective of this study was to investigate the influence of a directed cognitive function task during the FDG uptake period on uptake measurements both in naïve rats and at 2 days after mild lateral fluid percussion (mLFP) TBI. Adult male Sprague Dawley rats underwent FDG uptake with either cognitive testing with the Novel Object Recognition (NOR) test or No Novel Object (NNO), followed by PET scans at baseline (prior to injury) and at 2days post mLFP. At baseline, FDG uptake in the right hippocampus was elevated in rats completing the NOR in comparison to the NNO (control group). Further, the NNO group rats demonstrated a greater fold change in the FDG uptake between baseline and post injury scans than the NOR group. Overall, these data suggest that cognitive activity during FDG uptake affects the regional uptake pattern in the brain, increasing uptake at baseline and suppressing the effects of injury.

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Alteration of FDG uptake by performing novel object recognition task in a rat model of Traumatic Brain Injury

Publication date: March 2019

Source: NeuroImage, Volume 188

Author(s): Shalini Jaiswal, Nicole Hockenbury, Hongna Pan, Andrew Knutsen, Bernard J. Dardzinski, Kimberly R. Byrnes

Abstract

Traumatic Brain Injury (TBI) affects approximately 2.5 million people in the United States, of which 80% are considered to be mild (mTBI). Previous studies have shown that cerebral glucose uptake and metabolism are altered after brain trauma and functional metabolic deficits observed following mTBI are associated with changes in cognitive performance. Imaging of glucose uptake using [¹⁸F] Fluorodeoxyglucose (FDG) based Positron Emission Tomography (PET) with anesthesia during the uptake period demonstrated limited variability in results, but may have depressed uptake. Anesthesia has been found to interfere with blood glucose levels, and hence, FDG uptake. Conversely, forced cognitive testing during uptake may increase glucose demand in targeted regions, such as hippocampus, allowing for better differentiation of outcomes. Therefore, the objective of this study was to investigate the influence of a directed cognitive function task during the FDG uptake period on uptake measurements both in naïve rats and at 2 days after mild lateral fluid percussion (mLFP) TBI. Adult male Sprague Dawley rats underwent FDG uptake with either cognitive testing with the Novel Object Recognition (NOR) test or No Novel Object (NNO), followed by PET scans at baseline (prior to injury) and at 2days post mLFP. At baseline, FDG uptake in the right hippocampus was elevated in rats completing the NOR in comparison to the NNO (control group). Further, the NNO group rats demonstrated a greater fold change in the FDG uptake between baseline and post injury scans than the NOR group. Overall, these data suggest that cognitive activity during FDG uptake affects the regional uptake pattern in the brain, increasing uptake at baseline and suppressing the effects of injury.

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In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

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The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

Differential impact of age on survival in head and neck cancer according to classic Cox regression and decision tree analysis

Abstract

Objectives

To assess the impact of age on the survival of patients with head and neck squamous cell carcinoma (HNSCC) using different statistical methods.

Design

A retrospective population based study.

Setting

Surveillance, Epidemiology, and End Results database.

Subjects and methods

A total of 28639 patients with newly diagnosed HNSCC were enrolled between January 1, 2007, and December 31, 2013. The effect of age on 5‐year disease‐specific survival was calculated using a Kaplan‐Meier method and compared using log‐rank tests. A Cox proportional hazards model was used for a multivariate analysis. A classification and regression tree (CART) analysis that partitioned patients with significantly different Kaplan‐Meier curves was introduced to identify the important cancer‐related parameters influencing survival.

Results

Uni‐ and multivariate analyses indicated that patients who were older than 60 years had poorer 5‐year disease‐specific survival regardless of tumor subsite and TNM stage. However, the CART analysis determined that age played only a minor role in survival after comparing with other prognosticators. The relative importance of age using the Gini index was as follows: 3.21% for oral cancer, 8.32% for oropharyngeal cancer, 2.56% for hypopharyngeal cancer, and 16.51% for laryngeal cancer.

Conclusions

Different to traditional statistical methods, the CART analysis which was used to identify homogeneous populations, revealed that the impact of age varied for different patient groups according to the presence or absence of other prognosticators. This important information could help to guide our clinical decisions and future researches.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PZFbTg

Differential impact of age on survival in head and neck cancer according to classic Cox regression and decision tree analysis

Abstract

Objectives

To assess the impact of age on the survival of patients with head and neck squamous cell carcinoma (HNSCC) using different statistical methods.

Design

A retrospective population based study.

Setting

Surveillance, Epidemiology, and End Results database.

Subjects and methods

A total of 28639 patients with newly diagnosed HNSCC were enrolled between January 1, 2007, and December 31, 2013. The effect of age on 5‐year disease‐specific survival was calculated using a Kaplan‐Meier method and compared using log‐rank tests. A Cox proportional hazards model was used for a multivariate analysis. A classification and regression tree (CART) analysis that partitioned patients with significantly different Kaplan‐Meier curves was introduced to identify the important cancer‐related parameters influencing survival.

Results

Uni‐ and multivariate analyses indicated that patients who were older than 60 years had poorer 5‐year disease‐specific survival regardless of tumor subsite and TNM stage. However, the CART analysis determined that age played only a minor role in survival after comparing with other prognosticators. The relative importance of age using the Gini index was as follows: 3.21% for oral cancer, 8.32% for oropharyngeal cancer, 2.56% for hypopharyngeal cancer, and 16.51% for laryngeal cancer.

Conclusions

Different to traditional statistical methods, the CART analysis which was used to identify homogeneous populations, revealed that the impact of age varied for different patient groups according to the presence or absence of other prognosticators. This important information could help to guide our clinical decisions and future researches.

This article is protected by copyright. All rights reserved.

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A randomized controlled trial on the efficiency of free‐handed, pilot‐drill guided and fully‐guided implant surgery in partially edentulous patients

Abstract

Objectives

To compare the effectiveness of free‐handed (FH), pilot‐drill guided (PG) and fully‐guided (FG) implant surgery by means of the Apical Global Deviation (AGD) in relation to the additional financial cost and time spent.

Materials and methods

Thirty‐three partially edentulous patients in need of ≥2 implants in the posterior maxilla were randomly allocated to one of the following treatment groups: FH, PG, FG. Eleven patients (mean age 57; 8 females; altogether 26 implants) were treated by FH surgery, 11 (mean age 53; 7 females; altogether 24 implants) by PG surgery and 10 (mean age 60; 6 females; altogether 21 implants) by FG surgery. The accuracy in implant positioning was assessed by comparing the actual implant position to its planned position with the AGD as the main measure of effectiveness. Cost analysis included data on time investment (pre‐ and per‐operative) and operational cost. The efficiency of PG and FG surgery was assessed by means of the incremental cost‐effectiveness ratio (ICER), defined as the extra investment that is needed per unit reduction in AGD when compared to FH surgery.

Results

FG surgery was most effective (mean AGD: 0.97mm) and FH surgery was least effective (mean AGD: 2.11mm) in terms of surgical accuracy. As a result, 5/26 implants had to be restored with a cement‐retained restoration following FH surgery, although screw‐retention was planned for all implants in every group. The total time investment did not differ significantly between the 3 groups (p=0.811). A significant additional cost per implant was found for PG and FG as compared to FH surgery pointing to 8.29% (€176.54) and 10.45% (€222.52), respectively (p<0.001). The ICER revealed an additional cost of €5.48 and €4.12 per percent reduction in AGD for PG and FG surgery, respectively.

Conclusion

The extra operational cost for guided implant surgery is acceptable and clinically justified since cementation can be avoided. FG surgery is the most efficient surgical approach, even though the absolute operational cost is higher when compared to PG and FH surgery.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PYh8V0

A randomized controlled trial on the efficiency of free‐handed, pilot‐drill guided and fully‐guided implant surgery in partially edentulous patients

Abstract

Objectives

To compare the effectiveness of free‐handed (FH), pilot‐drill guided (PG) and fully‐guided (FG) implant surgery by means of the Apical Global Deviation (AGD) in relation to the additional financial cost and time spent.

Materials and methods

Thirty‐three partially edentulous patients in need of ≥2 implants in the posterior maxilla were randomly allocated to one of the following treatment groups: FH, PG, FG. Eleven patients (mean age 57; 8 females; altogether 26 implants) were treated by FH surgery, 11 (mean age 53; 7 females; altogether 24 implants) by PG surgery and 10 (mean age 60; 6 females; altogether 21 implants) by FG surgery. The accuracy in implant positioning was assessed by comparing the actual implant position to its planned position with the AGD as the main measure of effectiveness. Cost analysis included data on time investment (pre‐ and per‐operative) and operational cost. The efficiency of PG and FG surgery was assessed by means of the incremental cost‐effectiveness ratio (ICER), defined as the extra investment that is needed per unit reduction in AGD when compared to FH surgery.

Results

FG surgery was most effective (mean AGD: 0.97mm) and FH surgery was least effective (mean AGD: 2.11mm) in terms of surgical accuracy. As a result, 5/26 implants had to be restored with a cement‐retained restoration following FH surgery, although screw‐retention was planned for all implants in every group. The total time investment did not differ significantly between the 3 groups (p=0.811). A significant additional cost per implant was found for PG and FG as compared to FH surgery pointing to 8.29% (€176.54) and 10.45% (€222.52), respectively (p<0.001). The ICER revealed an additional cost of €5.48 and €4.12 per percent reduction in AGD for PG and FG surgery, respectively.

Conclusion

The extra operational cost for guided implant surgery is acceptable and clinically justified since cementation can be avoided. FG surgery is the most efficient surgical approach, even though the absolute operational cost is higher when compared to PG and FH surgery.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PYh8V0

Can photolysis of the CoC bond in coenzyme B12-dependent enzymes be used to mimic the native reaction?

Publication date: Available online 21 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Abdullah Al Mamun, Megan J. Toda, Pawel M. KozlowskiAbstractCoenzyme B12 (Adenosylcobalamin = AdoCbl)-dependent enzymes catalyze complex molecular transformations where cleavage of the CoC bond initiates the catalytic cycle. Alternatively, the CoC bond can be cleaved with light. In both cases, rupture of the CoC bond results in the formation of Co(II)/Ado radical pair (RP). Within the field of B12 chemistry, there has been a suspicion that photolytic cleavage can be used as a probe or a direct comparison of the native reaction. Herein, we seek to resolve what the connection between light-induced RP formation and the native catalytic cycle is. We used a combined QM/...

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Highly efficient of molybdenum trioxide-cadmium titanate nanocomposites for ultraviolet light photocatalytic and antimicrobial application: Influence of reactive oxygen species

Publication date: Available online 21 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Jia-Ming Zhu, Mojgan Hosseini, Ali Fakhri, Saboura Salari Rad, Tayebeh Hadadi, Nastaran NobakhtAbstractIn the present work we report the enhanced UV light photocatalytic performance of cadmium titanate photocatalyst by MoO3 for Drug pollutant degradation. The nano photocatalyst sample was synthesized employing the Pechini-ultrasonic-hydrothermal route. Therefore, the nano photocatalyst were characterized by various analytical devices. The wide scan X-ray photoelectron spectral study confirmed the MoO3 in the CdTiO3 matrix. The crystallite size calculated with the Debye-Scherrer equation (55.4, 57.0, 61.2 and 63.1 nm for pure CdTiO3, MoCdTi-0, MoCdTi-1, and MoCdTi-2 n...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rTLG0w

Can photolysis of the CoC bond in coenzyme B12-dependent enzymes be used to mimic the native reaction?

Publication date: Available online 21 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Abdullah Al Mamun, Megan J. Toda, Pawel M. KozlowskiAbstractCoenzyme B12 (Adenosylcobalamin = AdoCbl)-dependent enzymes catalyze complex molecular transformations where cleavage of the CoC bond initiates the catalytic cycle. Alternatively, the CoC bond can be cleaved with light. In both cases, rupture of the CoC bond results in the formation of Co(II)/Ado radical pair (RP). Within the field of B12 chemistry, there has been a suspicion that photolytic cleavage can be used as a probe or a direct comparison of the native reaction. Herein, we seek to resolve what the connection between light-induced RP formation and the native catalytic cycle is. We used a combined QM/...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LyzYBl

Highly efficient of molybdenum trioxide-cadmium titanate nanocomposites for ultraviolet light photocatalytic and antimicrobial application: Influence of reactive oxygen species

Publication date: Available online 21 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Jia-Ming Zhu, Mojgan Hosseini, Ali Fakhri, Saboura Salari Rad, Tayebeh Hadadi, Nastaran NobakhtAbstractIn the present work we report the enhanced UV light photocatalytic performance of cadmium titanate photocatalyst by MoO3 for Drug pollutant degradation. The nano photocatalyst sample was synthesized employing the Pechini-ultrasonic-hydrothermal route. Therefore, the nano photocatalyst were characterized by various analytical devices. The wide scan X-ray photoelectron spectral study confirmed the MoO3 in the CdTiO3 matrix. The crystallite size calculated with the Debye-Scherrer equation (55.4, 57.0, 61.2 and 63.1 nm for pure CdTiO3, MoCdTi-0, MoCdTi-1, and MoCdTi-2 n...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rTLG0w