A sweeter approach to vaccine design

(Source: ScienceNOW)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WOPTkf

HIV glycans and nanoparticle vaccines

(Source: ScienceNOW)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WOPNZV

Slowing blood flow to fight viral infection

(Source: ScienceNOW)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RN6zEQ

Choline acetyltransferase-expressing T cells are required to control chronic viral infection

Although widely studied as a neurotransmitter, T cell–derived acetylcholine (ACh) has recently been reported to play an important role in regulating immunity. However, the role of lymphocyte-derived ACh in viral infection is unknown. Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4+ and CD8+ T cells during lymphocytic choriomeningitis virus (LCMV) infection in an IL-21–dependent manner. Deletion of Chat within the T cell compartment in mice ablated vasodilation in response to infection, impaired the migration of antiviral T cells into infected tissues, and ultimately compromised the control of chronic LCMV clone 13 infection. Our results reveal a genetic proof of function fo...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WOPKxd

A simple technique to repair a residual oronasal fistula in bilateral cleft lip and palate patients

An anterior palatal oronasal fistula in a bilateral cleft lip and palate is a challenging clinical dilemma. The purpose of this paper is to present a two-stage technique to repair the fistula in consistent fashion. The technique was developed to avoid more complicated procedures that had greater morbidity to be used on larger oronasal defects that could not be treated in a single procedure.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2I0HF56

Discrepancies in Interpretation of the Minor Salivary Gland Biopsy in the Diagnosis of Sjögren syndrome

Although the minor salivary gland biopsy(MSGB) is a major criterion for diagnosis of Sjögren syndrome(SS), multiple studies have outlined difficulties in standardization.1,2 The purpose of this study was to answer the following question: In all patients referred for MSGB, did strict application of focus scoring criteria alter the sensitivity of and predictive value of the MSGB in the diagnosis of SS when compared to the initial interpretation?

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GfVzyQ

A simple technique to repair a residual oronasal fistula in bilateral cleft lip and palate patients

An anterior palatal oronasal fistula in a bilateral cleft lip and palate is a challenging clinical dilemma. The purpose of this paper is to present a two-stage technique to repair the fistula in consistent fashion. The technique was developed to avoid more complicated procedures that had greater morbidity to be used on larger oronasal defects that could not be treated in a single procedure.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2I0HF56

Discrepancies in Interpretation of the Minor Salivary Gland Biopsy in the Diagnosis of Sjögren syndrome

Although the minor salivary gland biopsy(MSGB) is a major criterion for diagnosis of Sjögren syndrome(SS), multiple studies have outlined difficulties in standardization.1,2 The purpose of this study was to answer the following question: In all patients referred for MSGB, did strict application of focus scoring criteria alter the sensitivity of and predictive value of the MSGB in the diagnosis of SS when compared to the initial interpretation?

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GfVzyQ

Eosinophil Peroxidase, GATA3 and T-bet as Tissue Biomarkers in Chronic Rhinosinusitis

Eosinophil peroxidase is a potential biomarker for eosinophilic chronic rhinosinusitis. Th2/Th1 polarization, as measured by GATA3 and T-bet, was not associated with eosinophilia or any clinical or histopathologic feature of chronic rhinosinusitis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UK5VtL

A Volumetric Survey of Aeroallergens in San Antonio, Texas From 2012-2017: Not All Allergens Fit The Mold

An aeroallergen survey of Texas trees, weeds and grasses does not exist. This is the first survey of the unique pollinating patterns in San Antonio, TX developed to tailor testing and immunotherapy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UPat2e

Stensen's duct dilation: case series of minimally invasive treatment

Stensen's duct dilation is a rare condition defined by a global or partial idiopathic dilation of the Stensen's duct. Affected patients usually show either aesthetic features, such as a tubular-shaped swelling in the cheek, or with mildly painful inflammatory episodes. Three women between the ages of 61 and 67 years were diagnosed with Stensen's duct dilatation after sialoMRI. They were treated with botulinum toxin A (BTX-A). Our preliminary results suggest that Botulinum Toxin A was efficient as a suspensive treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tc2Mr2

Plasmacytoid cells in salivary pleomorphic adenoma. An alternative interpretation of their immunohistochemical characteristics highlights function and capability for epithelial-mesenchymal transition

Plasmacytoid cells (PLCs) in salivary pleomorphic adenoma (SPA) are regarded as modified neoplastic myoepithelia and define plasmacytoid myoepithelioma (pMYO). However, histochemically, immunohistochemically and ultrastructurally, PLCs fail to demonstrate frank myogenous properties. Epithelial-mesenchymal transition (EMT) may explain the phenotypes in SPA. Our aim was to evaluate 1) PLCs with accepted or purported myoepithelial and EMT-related markers; and 2) pMYOs for PLAG1 aberrations by FISH.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2URd3EZ

Pericoronal radiolucency surrounding an impacted mandibular molar

A 19-year-old female with no significant past medical history was referred to an oral surgeon by her otolaryngologist (ENT) for evaluation of a radiolucency in the right mandible. She had been experiencing right-sided jaw discomfort for 4 months and 2 weeks prior to the date of the biopsy. She was evaluated by the ENT for bilateral tenderness of the ears, which was diagnosed as bilateral temporomandibular joint (TMJ) arthritis. A radiolucency of the right mandible was discovered upon radiographic imaging, which prompted referral to her oral surgeon.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UMtYIM

CLINICO-RADIOLOGICAL FOLLOW UP OF CHERUBISM WITH AGGRESSIVE CHARACTERISTICS: A SERIES OF 3 CASES

Cherubism is a rare autosomal dominant disorder characterized by degradation of bone that is replaced by fibrous tissue containing multinucleated giant cells. It clinically manifests as bilateral mandibular and maxillary enlargement. The recent World Health Organization (WHO) classification of 2017 now lists cherubism as one of the giant cell lesions of the jaws, distinct from fibro-osseous disorders.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t8ZPaL

Plasmacytoid cells in salivary pleomorphic adenoma. An alternative interpretation of their immunohistochemical characteristics highlights function and capability for epithelial-mesenchymal transition

Plasmacytoid cells (PLCs) in salivary pleomorphic adenoma (SPA) are regarded as modified neoplastic myoepithelia and define plasmacytoid myoepithelioma (pMYO). However, histochemically, immunohistochemically and ultrastructurally, PLCs fail to demonstrate frank myogenous properties. Epithelial-mesenchymal transition (EMT) may explain the phenotypes in SPA. Our aim was to evaluate 1) PLCs with accepted or purported myoepithelial and EMT-related markers; and 2) pMYOs for PLAG1 aberrations by FISH.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2URd3EZ

Eosinophil Peroxidase, GATA3 and T-bet as Tissue Biomarkers in Chronic Rhinosinusitis

Eosinophil peroxidase is a potential biomarker for eosinophilic chronic rhinosinusitis. Th2/Th1 polarization, as measured by GATA3 and T-bet, was not associated with eosinophilia or any clinical or histopathologic feature of chronic rhinosinusitis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UK5VtL

A Volumetric Survey of Aeroallergens in San Antonio, Texas From 2012-2017: Not All Allergens Fit The Mold

An aeroallergen survey of Texas trees, weeds and grasses does not exist. This is the first survey of the unique pollinating patterns in San Antonio, TX developed to tailor testing and immunotherapy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UPat2e

Stensen's duct dilation: case series of minimally invasive treatment

Stensen's duct dilation is a rare condition defined by a global or partial idiopathic dilation of the Stensen's duct. Affected patients usually show either aesthetic features, such as a tubular-shaped swelling in the cheek, or with mildly painful inflammatory episodes. Three women between the ages of 61 and 67 years were diagnosed with Stensen's duct dilatation after sialoMRI. They were treated with botulinum toxin A (BTX-A). Our preliminary results suggest that Botulinum Toxin A was efficient as a suspensive treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tc2Mr2

Association of geographic tongue and fissured tongue with ABO blood group among adult psoriasis patients – A novel study from a tertiary care hospital in Saudi Arabia

We aimed to determine if there was any association between geographic tongue and fissured tongue with ABO blood group among adult psoriasis patients in Saudi Arabia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tc2H6I

Pericoronal radiolucency surrounding an impacted mandibular molar

A 19-year-old female with no significant past medical history was referred to an oral surgeon by her otolaryngologist (ENT) for evaluation of a radiolucency in the right mandible. She had been experiencing right-sided jaw discomfort for 4 months and 2 weeks prior to the date of the biopsy. She was evaluated by the ENT for bilateral tenderness of the ears, which was diagnosed as bilateral temporomandibular joint (TMJ) arthritis. A radiolucency of the right mandible was discovered upon radiographic imaging, which prompted referral to her oral surgeon.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UMtYIM