Nasopharyngeal teratomas are rare tumours, responsible for a high birth mortality rate from acute respiratory distress. Palatine localization can lead to an embryopathogenic mechanical obstacle responsible for a cleft palate. The aim of this study was to update current knowledge concerning the management of this rare pathological association.We conducted a multicentre, retrospective study by case analysis. The inclusion criteria were patients of any age under care for a nasopharyngeal teratoma associated with a velopalatine cleft.
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Τετάρτη 19 Σεπτεμβρίου 2018
Management of nasopharyngeal teratomas associated with cleft palate
Impact of postoperative radiotherapy on survival and loco-regional control in node-negative oral cavity tumours classified as T3 using the AJCC Cancer Staging Manual eighth edition
According to the eighth edition of the AJCC Cancer Staging Manual (AJCC8), a depth of invasion (DOI) >10mm is classified as pT3, representing a locally advanced tumour requiring postoperative radiotherapy (PORT). When node-negative, however, evidence regarding whether PORT improves loco-regional control or survival is unclear. To clarify this, two cohorts of patients were studied: (1) patients classified as pT3N0 by the seventh edition of the AJCC manual (AJCC7), with DOI >10mm and a tumour diameter >4cm (17 patients who received PORT), and (2) patients classified as pT1N0 and pT2N0 by AJCC7, with DOI >10mm and a tumour diameter <4cm (55 patients who did not receive PORT).
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Treatment of skeletal open bite using a navigation system: CAD/CAM osteotomy and drilling guides combined with pre-bent titanium plates
Severe skeletal open bite associated with posterior vertical maxillary excess and mandibular deformity is considered a difficult problem in orthodontic and surgical treatment. This study used a navigation system for the correction of severe skeletal open bite in order to accurately transfer the virtual plan to the actual operation and achieve precise rigid internal fixation in bimaxillary osteotomies of the jaws. Twelve patients with a severe skeletal open bite associated with vertical maxillary excess and mandibular deformity were recruited.
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Management of nasopharyngeal teratomas associated with cleft palate
Nasopharyngeal teratomas are rare tumours, responsible for a high birth mortality rate from acute respiratory distress. Palatine localization can lead to an embryopathogenic mechanical obstacle responsible for a cleft palate. The aim of this study was to update current knowledge concerning the management of this rare pathological association.We conducted a multicentre, retrospective study by case analysis. The inclusion criteria were patients of any age under care for a nasopharyngeal teratoma associated with a velopalatine cleft.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MPC1jw
Impact of postoperative radiotherapy on survival and loco-regional control in node-negative oral cavity tumours classified as T3 using the AJCC Cancer Staging Manual eighth edition
According to the eighth edition of the AJCC Cancer Staging Manual (AJCC8), a depth of invasion (DOI) >10mm is classified as pT3, representing a locally advanced tumour requiring postoperative radiotherapy (PORT). When node-negative, however, evidence regarding whether PORT improves loco-regional control or survival is unclear. To clarify this, two cohorts of patients were studied: (1) patients classified as pT3N0 by the seventh edition of the AJCC manual (AJCC7), with DOI >10mm and a tumour diameter >4cm (17 patients who received PORT), and (2) patients classified as pT1N0 and pT2N0 by AJCC7, with DOI >10mm and a tumour diameter <4cm (55 patients who did not receive PORT).
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2plYZWf
Treatment of skeletal open bite using a navigation system: CAD/CAM osteotomy and drilling guides combined with pre-bent titanium plates
Severe skeletal open bite associated with posterior vertical maxillary excess and mandibular deformity is considered a difficult problem in orthodontic and surgical treatment. This study used a navigation system for the correction of severe skeletal open bite in order to accurately transfer the virtual plan to the actual operation and achieve precise rigid internal fixation in bimaxillary osteotomies of the jaws. Twelve patients with a severe skeletal open bite associated with vertical maxillary excess and mandibular deformity were recruited.
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Lung Denervation Cuts COPD-Related Events, Admissions
(MedPage Today) -- One-time therapy showed most benefit in highly symptomatic patients (Source: MedPage Today Allergy)
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Lung Denervation Cuts COPD-Related Events, Admissions
(MedPage Today) -- One-time therapy showed most benefit in highly symptomatic patients (Source: MedPage Today Allergy)
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TIGIT: a novel immunotherapy target moving from bench to bedside
AbstractTreatment strategies for patients with advanced solid tumors have traditionally been based on three different paradigms: surgery, cytotoxics (chemotherapy or radiation therapy) and targeted therapies. Immunotherapy has emerged as a novel treatment paradigm in our armamentarium. Unfortunately, most patients still do not benefit from immunotherapy. These patients often have "cold tumors" characterized by a paucity of effector T cells in the tumor microenvironment, low mutational load, low neoantigen burden and often an immunosuppressive tumor microenvironment. TIGIT is an immunoreceptor inhibitory checkpoint that has been implicated in tumor immunosurveillance. Exp ression of TIGIT has been demonstrated in both NK cells and T cells and plays a role in their activation and maturat...
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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The role of CCR5 in directing the mobilization and biological function of CD11b + Gr1 + Ly6C low polymorphonuclear myeloid cells in cancer
AbstractBone marrow (BM) cells of the hematopoietic system, also known as BM-derived leukocytes (BMD), are mobilized from the BM to the blood and then colonize tumor sites. These cells then become key players in either promoting or regulating the development and progression of tumors. Among the cells that suppress anti-tumor immunity are regulatory T cells (Tregs), tumor-associated macrophages (TAMS) and myeloid-derived suppressor cells (MDSC). MDSC comprise CD11b+Gr1+Ly6Clow polymorphonuclear myeloid cells (PMN-MDSC), and CD11b+Gr1+Ly6Chigh monocytic myeloid cells (Mo-MDSC). Several studies including ours have identified the CCR2 –CCL2 axis as the key driver of the mobilization of monocytic cells from the BM to the blood and later their colonization at the tumor site. The current review...
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TIGIT: a novel immunotherapy target moving from bench to bedside
AbstractTreatment strategies for patients with advanced solid tumors have traditionally been based on three different paradigms: surgery, cytotoxics (chemotherapy or radiation therapy) and targeted therapies. Immunotherapy has emerged as a novel treatment paradigm in our armamentarium. Unfortunately, most patients still do not benefit from immunotherapy. These patients often have "cold tumors" characterized by a paucity of effector T cells in the tumor microenvironment, low mutational load, low neoantigen burden and often an immunosuppressive tumor microenvironment. TIGIT is an immunoreceptor inhibitory checkpoint that has been implicated in tumor immunosurveillance. Exp ression of TIGIT has been demonstrated in both NK cells and T cells and plays a role in their activation and maturat...
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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The role of CCR5 in directing the mobilization and biological function of CD11b + Gr1 + Ly6C low polymorphonuclear myeloid cells in cancer
AbstractBone marrow (BM) cells of the hematopoietic system, also known as BM-derived leukocytes (BMD), are mobilized from the BM to the blood and then colonize tumor sites. These cells then become key players in either promoting or regulating the development and progression of tumors. Among the cells that suppress anti-tumor immunity are regulatory T cells (Tregs), tumor-associated macrophages (TAMS) and myeloid-derived suppressor cells (MDSC). MDSC comprise CD11b+Gr1+Ly6Clow polymorphonuclear myeloid cells (PMN-MDSC), and CD11b+Gr1+Ly6Chigh monocytic myeloid cells (Mo-MDSC). Several studies including ours have identified the CCR2 –CCL2 axis as the key driver of the mobilization of monocytic cells from the BM to the blood and later their colonization at the tumor site. The current review...
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Specific Enzymes Cause Mutations That Fuel Aggressive Skin Cancer in Patients With RDEB, Study Shows
| Specific Enzymes Cause Mutations That Fuel Aggressive Skin Cancer in Patients With RDEB, Study Shows Epidermolysis Bullosa NewsFull coverage |
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Galera Therapeutics Nabs $150 Million to Drive Lead Therapeutic Into Phase III
| Galera Therapeutics Nabs $150 Million to Drive Lead Therapeutic Into Phase III BioSpace (press release) (blog)Galera raises another $150 million Philly.com (blog)Cancer Therapy Start-Up Raises Record Investment KMOX (blog)St. Louis biotech drug startup Galera raises $150 million STLtoday.comFull coverage |
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Galera Therapeutics Nabs $150 Million to Drive Lead Therapeutic Into Phase III
| Galera Therapeutics Nabs $150 Million to Drive Lead Therapeutic Into Phase III BioSpace (press release) (blog)Galera raises another $150 million Philly.com (blog)Cancer Therapy Start-Up Raises Record Investment KMOX (blog)St. Louis biotech drug startup Galera raises $150 million STLtoday.comFull coverage |
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Thyroid Cancer Drugs Market Size, Share, Emerging Trends, Analysis and Forecasts 2018-2026
| Thyroid Cancer Drugs Market Size, Share, Emerging Trends, Analysis and Forecasts 2018-2026 Morgan Newspaper USA (press release) (blog)Global Thyroid Cancer Treatment Market will take Worldwide Lead with Impressive Gross Margin by 2025 : Mylan ... mymarketgazette.comGlobal Anaplastic Thyroid Cancer Drug Market 2018 – Daiichi Sankyo Company, Limited, Genelux Corporation Herald of BusinessFull coverage |
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7 Warning Signs of Thyroid Cancer
| 7 Warning Signs of Thyroid Cancer TAPinto.net(HealthNewsDigest.com) - Summit, NJ - HealthNewsDigest.comFull coverage |
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Thyroid Cancer Drugs Market Size, Share, Emerging Trends, Analysis and Forecasts 2018-2026
| Thyroid Cancer Drugs Market Size, Share, Emerging Trends, Analysis and Forecasts 2018-2026 Morgan Newspaper USA (press release) (blog)Global Thyroid Cancer Treatment Market will take Worldwide Lead with Impressive Gross Margin by 2025 : Mylan ... mymarketgazette.comGlobal Anaplastic Thyroid Cancer Drug Market 2018 – Daiichi Sankyo Company, Limited, Genelux Corporation Herald of BusinessFull coverage |
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7 Warning Signs of Thyroid Cancer
| 7 Warning Signs of Thyroid Cancer TAPinto.net(HealthNewsDigest.com) - Summit, NJ - HealthNewsDigest.comFull coverage |
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Cochlear implantation in children with congenital long QT syndrome: Introduction of an evidence-based pathway of care
. (Source: Cochlear Implants International)
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