Condition: Anesthesia, Local Interventions: Drug: Lidocaine 1%/Epi 1:200000; Other: Na Cl 0.9%/Epi 1:200000 Sponsor: Ain Shams University Completed (Source: ClinicalTrials.gov)
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Condition: Anesthesia, Local Interventions: Drug: Lidocaine 1%/Epi 1:200000; Other: Na Cl 0.9%/Epi 1:200000 Sponsor: Ain Shams University Completed (Source: ClinicalTrials.gov)
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Condition: HIV/AIDS Intervention: Biological: PGT121 + VRC07-523LS Sponsors: International AIDS Vaccine Initiative; Beth Israel Deaconess Medical Center; Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Ebola Virus Interventions: Drug: ZMapp; Drug: Remdesivir; Drug: MAb114 Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Condition: Malaria Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Condition: HIV/AIDS Intervention: Biological: PGT121 + VRC07-523LS Sponsors: International AIDS Vaccine Initiative; Beth Israel Deaconess Medical Center; Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Ebola Virus Interventions: Drug: ZMapp; Drug: Remdesivir; Drug: MAb114 Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Conditions: Breast Cancer; Estrogen Receptor-positive Breast Cancer; Healthy Intervention: Sponsors: Duke University; United States Department of Defense Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Malaria Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Condition: Crohn Disease Interventions: Drug: Anti-TNF Drug; Drug: Ustekinumab Sponsor: Hospices Civils de Lyon Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Gingivitis; Mucositis Intervention: Behavioral: Experimentally induced plaque Sponsor: University of Campinas, Brazil Completed (Source: ClinicalTrials.gov)
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Obesity is thought to be associated with poor asthma control, increased health resource utilization, and reduced responsiveness to inhaled corticosteroids. (Source: Annals of Allergy, Asthma and Immunology)
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Obesity is thought to be associated with poor asthma control, increased health resource utilization, and reduced responsiveness to inhaled corticosteroids. (Source: Annals of Allergy, Asthma and Immunology)
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This study sought to identify novel CD8+ T cell homing markers by studying acute graft versus host disease (aGvHD), typically involving increased T cell homing to the skin and gut. FACS-sorted skin-homing (CD8β+/CLA+), gut-homing (CD8β+/integrinβ7+), and reference (CD8β+/CLA-/integrinβ7-) T cells were compared in patients affected by cutaneous and/or gastrointestinal aGVHD. Microarray analysis, Q-PCR and flow cytometry revealed increased expression of peptidase inhibitor 16 (PI16) in skin-homing CD8+ T cells. Robust association of PI16 with skin-homing was confirmed in all types of aGvHD and in healthy controls, too. PI16 was not observed on CLA+ leukocytes other than T cells. Induction of PI16 expression on skin-homing T cells occurred independently of vitamin D3. Among skin-homing T...
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This article is protected by copyright. All rights reserved. PMID: 30365177 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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This article is protected by copyright. All rights reserved. PMID: 30365177 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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To summarize the current management of the neck lymph node basin for head and neck non-melanoma skin cancers.
Over the last 5 years, there have been updates to staging for cSCC and MCC. T classification of the AJCC staging system has been changed to match the UICC staging system. MCC staging has been updated based on data from the National Cancer Data Base. Sentinel lymph node biopsy, while established in MCC, is playing a growing role in the management of high-risk N0 cSCC.
The optimal management of N0 neck varies by metastatic potential. In low-risk malignancy, no workup is necessary. In cSCC, risk stratification is necessary. High-risk tumors with N0 necks should undergo preoperative imaging with CT and targeted FNA of suspicious lymph nodes. If radiologically negative, a SLNB should be considered. Selective neck dissection should be performed for N+ disease and positive SLNB. Elective neck dissection is not routinely recommended and should be reserved for positive parotid nodal disease. Merkel cell carcinoma has high rates of nodal metastases and requires preoperative imaging with targeted FNA of suspected metastases. SLNB should be performed for N0 disease to guide prognostication and further treatment. Management of negative SLN is controversial, and most can be observed while radiation may be considered for high-risk patients. Positive SLN requires completion neck dissection and radiation.
To summarize the current management of the neck lymph node basin for head and neck non-melanoma skin cancers.
Over the last 5 years, there have been updates to staging for cSCC and MCC. T classification of the AJCC staging system has been changed to match the UICC staging system. MCC staging has been updated based on data from the National Cancer Data Base. Sentinel lymph node biopsy, while established in MCC, is playing a growing role in the management of high-risk N0 cSCC.
The optimal management of N0 neck varies by metastatic potential. In low-risk malignancy, no workup is necessary. In cSCC, risk stratification is necessary. High-risk tumors with N0 necks should undergo preoperative imaging with CT and targeted FNA of suspicious lymph nodes. If radiologically negative, a SLNB should be considered. Selective neck dissection should be performed for N+ disease and positive SLNB. Elective neck dissection is not routinely recommended and should be reserved for positive parotid nodal disease. Merkel cell carcinoma has high rates of nodal metastases and requires preoperative imaging with targeted FNA of suspected metastases. SLNB should be performed for N0 disease to guide prognostication and further treatment. Management of negative SLN is controversial, and most can be observed while radiation may be considered for high-risk patients. Positive SLN requires completion neck dissection and radiation.
To summarize the current management of the neck lymph node basin for head and neck non-melanoma skin cancers.
Over the last 5 years, there have been updates to staging for cSCC and MCC. T classification of the AJCC staging system has been changed to match the UICC staging system. MCC staging has been updated based on data from the National Cancer Data Base. Sentinel lymph node biopsy, while established in MCC, is playing a growing role in the management of high-risk N0 cSCC.
The optimal management of N0 neck varies by metastatic potential. In low-risk malignancy, no workup is necessary. In cSCC, risk stratification is necessary. High-risk tumors with N0 necks should undergo preoperative imaging with CT and targeted FNA of suspicious lymph nodes. If radiologically negative, a SLNB should be considered. Selective neck dissection should be performed for N+ disease and positive SLNB. Elective neck dissection is not routinely recommended and should be reserved for positive parotid nodal disease. Merkel cell carcinoma has high rates of nodal metastases and requires preoperative imaging with targeted FNA of suspected metastases. SLNB should be performed for N0 disease to guide prognostication and further treatment. Management of negative SLN is controversial, and most can be observed while radiation may be considered for high-risk patients. Positive SLN requires completion neck dissection and radiation.
To summarize the current management of the neck lymph node basin for head and neck non-melanoma skin cancers.
Over the last 5 years, there have been updates to staging for cSCC and MCC. T classification of the AJCC staging system has been changed to match the UICC staging system. MCC staging has been updated based on data from the National Cancer Data Base. Sentinel lymph node biopsy, while established in MCC, is playing a growing role in the management of high-risk N0 cSCC.
The optimal management of N0 neck varies by metastatic potential. In low-risk malignancy, no workup is necessary. In cSCC, risk stratification is necessary. High-risk tumors with N0 necks should undergo preoperative imaging with CT and targeted FNA of suspicious lymph nodes. If radiologically negative, a SLNB should be considered. Selective neck dissection should be performed for N+ disease and positive SLNB. Elective neck dissection is not routinely recommended and should be reserved for positive parotid nodal disease. Merkel cell carcinoma has high rates of nodal metastases and requires preoperative imaging with targeted FNA of suspected metastases. SLNB should be performed for N0 disease to guide prognostication and further treatment. Management of negative SLN is controversial, and most can be observed while radiation may be considered for high-risk patients. Positive SLN requires completion neck dissection and radiation.
