Comparison of image quality and lesion detection between digital and analog PET/CT

Abstract

Objective

The purpose of this study was to compare image quality and lesion detection capability between a digital and an analog PET/CT system in oncological patients.

Materials and methods

One hundred oncological patients (62 men, 38 women; mean age of 65 ± 12 years) were prospectively included from January–June 2018. All patients, who accepted to be scanned by two systems, consecutively underwent a single day, dual imaging protocol (digital and analog PET/CT). Three nuclear medicine physicians evaluated image quality using a 4-point scale (−1, poor; 0, fair; 1, good; 2, excellent) and detection capability by counting the number of lesions with increased radiotracer uptake. Differences were considered significant for a p value <0.05.

Results

Improved image quality in the digital over the analog system was observed in 54% of the patients (p = 0.05, 95% CI, 44.2–63.5). The percentage of interrater concordance in lesion detection capability between the digital and analog systems was 97%, with an interrater measure agreement of κ = 0.901 (p < 0.0001). Although there was no significant difference in the total number of lesions detected by the two systems (digital: 5.03 ± 10.6 vs. analog: 4.53 ± 10.29; p = 0.7), the digital system detected more lesions in 22 of 83 of PET+ patients (26.5%) (p = 0.05, 95% CI, 17.9–36.7). In these 22 patients, all lesions detected by the digital PET/CT (and not by the analog PET/CT) were < 10 mm.

Conclusion

Digital PET/CT offers improved image quality and lesion detection capability over the analog PET/CT in oncological patients, and even better for sub-centimeter lesions.

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Prescription Opioids May Raise Pneumonia Risk

(Source: Pulmonary Medicine News - Doctors Lounge)

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E - Cigarette Aerosol Exposure Tied to Asthma Symptoms

Findings seen among youth reporting asthma diagnosis, secondhand exposure to e - cigarette aerosols (Source: Pulmonary Medicine News - Doctors Lounge)

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The science is clear: with HIV, undetectable equals untransmittable

(NIH/National Institute of Allergy and Infectious Diseases) An overwhelming body of clinical evidence has firmly established the HIV Undetectable = Untransmittable (U=U) concept as scientifically sound. U=U means that people living with HIV who achieve and maintain an undetectable viral load -- the amount of HIV in the blood -- by taking and adhering to antiretroviral therapy (ART) as prescribed cannot sexually transmit the virus to others. NIAID officials review the scientific evidence underlying U=U and discuss implications of widespread acceptance of the message. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Comparison of image quality and lesion detection between digital and analog PET/CT

Abstract

Objective

The purpose of this study was to compare image quality and lesion detection capability between a digital and an analog PET/CT system in oncological patients.

Materials and methods

One hundred oncological patients (62 men, 38 women; mean age of 65 ± 12 years) were prospectively included from January–June 2018. All patients, who accepted to be scanned by two systems, consecutively underwent a single day, dual imaging protocol (digital and analog PET/CT). Three nuclear medicine physicians evaluated image quality using a 4-point scale (−1, poor; 0, fair; 1, good; 2, excellent) and detection capability by counting the number of lesions with increased radiotracer uptake. Differences were considered significant for a p value <0.05.

Results

Improved image quality in the digital over the analog system was observed in 54% of the patients (p = 0.05, 95% CI, 44.2–63.5). The percentage of interrater concordance in lesion detection capability between the digital and analog systems was 97%, with an interrater measure agreement of κ = 0.901 (p < 0.0001). Although there was no significant difference in the total number of lesions detected by the two systems (digital: 5.03 ± 10.6 vs. analog: 4.53 ± 10.29; p = 0.7), the digital system detected more lesions in 22 of 83 of PET+ patients (26.5%) (p = 0.05, 95% CI, 17.9–36.7). In these 22 patients, all lesions detected by the digital PET/CT (and not by the analog PET/CT) were < 10 mm.

Conclusion

Digital PET/CT offers improved image quality and lesion detection capability over the analog PET/CT in oncological patients, and even better for sub-centimeter lesions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SSPlrm

Prescription Opioids May Raise Pneumonia Risk

(Source: Pulmonary Medicine News - Doctors Lounge)

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E - Cigarette Aerosol Exposure Tied to Asthma Symptoms

Findings seen among youth reporting asthma diagnosis, secondhand exposure to e - cigarette aerosols (Source: Pulmonary Medicine News - Doctors Lounge)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CcNYg0

The science is clear: with HIV, undetectable equals untransmittable

(NIH/National Institute of Allergy and Infectious Diseases) An overwhelming body of clinical evidence has firmly established the HIV Undetectable = Untransmittable (U=U) concept as scientifically sound. U=U means that people living with HIV who achieve and maintain an undetectable viral load -- the amount of HIV in the blood -- by taking and adhering to antiretroviral therapy (ART) as prescribed cannot sexually transmit the virus to others. NIAID officials review the scientific evidence underlying U=U and discuss implications of widespread acceptance of the message. (Source: EurekAlert! - Infectious and Emerging Diseases)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rip9ta

Seeking Treatment for TMDs: What Patients Can Expect from Non-Dental Healthcare Providers

The dental profession has long been the primary source for clinical management of patients with temporomandibular disorders (TMDs). However, patients with a facial pain problem may seek diagnosis and/or treatment from other healthcare providers. These providers may be physicians or other doctoral-level practitioners, or they could be members of various allied groups such as physical therapists or occupational therapists, acupuncturists, etc. However, little has been written about what patients might experience if they seek out care on their own outside of the dental profession.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TF5DUA

5-Aza-CdR Promotes Partial MGMT Demethylation and Modifies Expression of Different Genes in OSCC

Treatment strategies for Oral Squamous Cell Carcinoma (OSCC) vary based on the stage of diagnosis. Surgery and radiotherapy are options for localized lesions for stage I patients, while chemotherapy is the main treatment for metastatic OSCC. However, aggressive tumors can relapse, causing frequently the death of the patient. In an attempt to address this, novel treatment protocols using epigenetic drugs that alter the epigenetic profile have emerged as an alternative to control tumor growth and metastasis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D36s3S

Seeking Treatment for TMDs: What Patients Can Expect from Non-Dental Healthcare Providers

The dental profession has long been the primary source for clinical management of patients with temporomandibular disorders (TMDs). However, patients with a facial pain problem may seek diagnosis and/or treatment from other healthcare providers. These providers may be physicians or other doctoral-level practitioners, or they could be members of various allied groups such as physical therapists or occupational therapists, acupuncturists, etc. However, little has been written about what patients might experience if they seek out care on their own outside of the dental profession.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TF5DUA

5-Aza-CdR Promotes Partial MGMT Demethylation and Modifies Expression of Different Genes in OSCC

Treatment strategies for Oral Squamous Cell Carcinoma (OSCC) vary based on the stage of diagnosis. Surgery and radiotherapy are options for localized lesions for stage I patients, while chemotherapy is the main treatment for metastatic OSCC. However, aggressive tumors can relapse, causing frequently the death of the patient. In an attempt to address this, novel treatment protocols using epigenetic drugs that alter the epigenetic profile have emerged as an alternative to control tumor growth and metastasis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D36s3S

Low Dose Multi-OIT for Food Allergy (LoMo)

Condition:   Food Allergy Intervention:   Other: multi-OIT Sponsor:   The Hospital for Sick Children Recruiting (Source: ClinicalTrials.gov)

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Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the " RITUXIMAB 3 " Trial

Condition:   Autoimmune Diseases Interventions:   Drug: Rituximab;   Drug: corticosteroids'therapy Sponsor:   University Hospital, Rouen Not yet recruiting (Source: ClinicalTrials.gov)

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Low Dose Multi-OIT for Food Allergy (LoMo)

Condition:   Food Allergy Intervention:   Other: multi-OIT Sponsor:   The Hospital for Sick Children Recruiting (Source: ClinicalTrials.gov)

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Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the " RITUXIMAB 3 " Trial

Condition:   Autoimmune Diseases Interventions:   Drug: Rituximab;   Drug: corticosteroids'therapy Sponsor:   University Hospital, Rouen Not yet recruiting (Source: ClinicalTrials.gov)

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Food Allergies: Common and Severe Among U.S. Adults (CME/CE)

(MedPage Today) -- Nearly half of respondents who reported food allergy symptoms consistent with IgE-mediated reactions developed food allergies as adults (Source: MedPage Today Allergy)

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Food Allergy: Not Just a Kids' Problem

(MedPage Today) -- Affects more than 26 million U.S. adults -- but half of those who think they have allergies are undiagnosed (Source: MedPage Today Allergy)

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Food Allergies: Common and Severe Among U.S. Adults (CME/CE)

(MedPage Today) -- Nearly half of respondents who reported food allergy symptoms consistent with IgE-mediated reactions developed food allergies as adults (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D326Kj

Food Allergy: Not Just a Kids' Problem

(MedPage Today) -- Affects more than 26 million U.S. adults -- but half of those who think they have allergies are undiagnosed (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Re5DOp