Characterization of a subgroup of non-type 2 asthma with cow’s milk hypersensitivity in young subjects

Abstract

Background

Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control.

Objective

Our aim was to further characterize this subgroup of non-type 2 asthmatics, including the use of a broad panel of inflammation-related proteins.

Methods

Sex- and age-matched subjects (10–35 years old) were divided into three groups with regard to history of asthma and atopy: non-atopic asthmatics with perceived cow's milk hypersensitivity but with IgE antibodies < 0.35 kU_A/L (NAA; n = 24), non-atopic controls with IgE < 0.35 kU_A/L (NAC; n = 24), and atopic asthmatics with IgE ≥ 0.35 kU_A/L (AA; n = 29). Serum or plasma were analysed using the multi-allergen tests Phadiatop and fx5 (ImmunoCAP), a multiplex immunoassay comprising 92 inflammation-related proteins (Proseek Inflammation), and an ELISA for human neutrophil lipocalin (S-HNL). Fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, C-reactive protein (CRP), airway responsiveness to methacholine (PD₂₀), and asthma-related quality of life (mAQLQ) were also measured.

Results

NAA had lower FeNO (p < 0.001) and B-Eos count (p < 0.001), but scored worse on mAQLQ (p = 0.045) compared with AA. NAA displayed higher levels of matrix metalloproteinase-1 (MMP-1) compared with both NAC (p = 0.011) and AA (p = 0.001), and lower PD₂₀ compared with NAC (p < 0.001). In NAA, S-HNL correlated negatively with PD₂₀ (rho = − 0.048, p < 0.05) and CRP correlated negatively with mAQLQ (rho = − 0.439, p < 0.05).

Conclusion

In a subgroup of non-atopic young asthmatics with perceived cow's milk hypersensitivity we observed poor asthma-related quality of life, airway hyperresponsiveness, and clinically relevant non-type 2 inflammation. MMP-1 was elevated in this group, which deserves further studies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SQl9ku

Characterization of a subgroup of non-type 2 asthma with cow’s milk hypersensitivity in young subjects

Abstract

Background

Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control.

Objective

Our aim was to further characterize this subgroup of non-type 2 asthmatics, including the use of a broad panel of inflammation-related proteins.

Methods

Sex- and age-matched subjects (10–35 years old) were divided into three groups with regard to history of asthma and atopy: non-atopic asthmatics with perceived cow's milk hypersensitivity but with IgE antibodies < 0.35 kU_A/L (NAA; n = 24), non-atopic controls with IgE < 0.35 kU_A/L (NAC; n = 24), and atopic asthmatics with IgE ≥ 0.35 kU_A/L (AA; n = 29). Serum or plasma were analysed using the multi-allergen tests Phadiatop and fx5 (ImmunoCAP), a multiplex immunoassay comprising 92 inflammation-related proteins (Proseek Inflammation), and an ELISA for human neutrophil lipocalin (S-HNL). Fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, C-reactive protein (CRP), airway responsiveness to methacholine (PD₂₀), and asthma-related quality of life (mAQLQ) were also measured.

Results

NAA had lower FeNO (p < 0.001) and B-Eos count (p < 0.001), but scored worse on mAQLQ (p = 0.045) compared with AA. NAA displayed higher levels of matrix metalloproteinase-1 (MMP-1) compared with both NAC (p = 0.011) and AA (p = 0.001), and lower PD₂₀ compared with NAC (p < 0.001). In NAA, S-HNL correlated negatively with PD₂₀ (rho = − 0.048, p < 0.05) and CRP correlated negatively with mAQLQ (rho = − 0.439, p < 0.05).

Conclusion

In a subgroup of non-atopic young asthmatics with perceived cow's milk hypersensitivity we observed poor asthma-related quality of life, airway hyperresponsiveness, and clinically relevant non-type 2 inflammation. MMP-1 was elevated in this group, which deserves further studies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SQl9ku

Asymptomatic right cheek nodule in a 65-year-old female

A 65-year-old African American female presented to the Harlem Hospital Center, Department of Oral and Maxillofacial Surgery for evaluation of a persistent right buccal mass (Figure 1). The patient incidentally discovered the lesion three months prior, and she denied any fluctuations in size or discomfort from the site. She reported no past medical history and was not taking any prescription medications at the time. Her substance history was positive for regular tobacco (4.5 pack years) and alcohol (1-2 drinks day) consumption, and she admitted to using marijuana and cocaine recreationally.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2tz99Vo

Asymptomatic right cheek nodule in a 65-year-old female

A 65-year-old African American female presented to the Harlem Hospital Center, Department of Oral and Maxillofacial Surgery for evaluation of a persistent right buccal mass (Figure 1). The patient incidentally discovered the lesion three months prior, and she denied any fluctuations in size or discomfort from the site. She reported no past medical history and was not taking any prescription medications at the time. Her substance history was positive for regular tobacco (4.5 pack years) and alcohol (1-2 drinks day) consumption, and she admitted to using marijuana and cocaine recreationally.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2tz99Vo

Clinical management for T1 and T2 external auditory canal cancer

The purpose of this study was to clarify the impact of superficial parotidectomy and postoperative radiotherapy (PORT) for the surgical treatment of early stage squamous cell carcinoma (SCC) in external auditory canal (EAC).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TWw6NU

Oral administration of an herbal medicine to prevent progressive hearing loss in a mouse model of diabetes

Tsumura Suzuki Obese Diabetes (TSOD) mice exhibit early age-associated hearing loss. Histopathological analysis of these mice shows narrowing of capillaries in the stria vascularis and chronic reduction of blood flow in the cochlea. In this study, we investigated the effect of oral administration of a herbal medicine or calorie restriction on hearing in TSOD mice.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BMva7M

Clinical management for T1 and T2 external auditory canal cancer

The purpose of this study was to clarify the impact of superficial parotidectomy and postoperative radiotherapy (PORT) for the surgical treatment of early stage squamous cell carcinoma (SCC) in external auditory canal (EAC).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TWw6NU

Oral administration of an herbal medicine to prevent progressive hearing loss in a mouse model of diabetes

Tsumura Suzuki Obese Diabetes (TSOD) mice exhibit early age-associated hearing loss. Histopathological analysis of these mice shows narrowing of capillaries in the stria vascularis and chronic reduction of blood flow in the cochlea. In this study, we investigated the effect of oral administration of a herbal medicine or calorie restriction on hearing in TSOD mice.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BMva7M

“Return to play” after facial injuries: is it time for a consensus view?

The telephone rings: "Mr X has had a fractured jaw repaired but we've been told that he's not to play for three months – we desperately need him – when do you think he can play again?" You see another player with an asymptomatic fracture of the orbital floor: "When can I play again?" These are both hypothetical, but very common.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GS78f3

Tubomanometry and EarPopper Devices for Eustachian Tube Function Testing

Condition:   Eustachian Tube Dysfunction Interventions:   Device: EarPopper;   Device: Tympanometry;   Device: Tubomanometry Sponsors:   University of Pittsburgh;   National Institute on Deafness and Other Communication Disorders (NIDCD) Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2tty250

Subject ´s Preference Regarding Hearing Performance and Functionality Using a New Sound Processor

Conditions:   Deafness; Sensoneural Single Sided;   Conductive Hearing Loss;   Mixed Hearing Loss Intervention:   Device: Investigational device - Sound Processor Sponsor:   Cochlear Bone Anchored Solutions Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GS73bf

Electrocochleography Function for Monitoring Residual Hearing

Condition:   Hearing Loss, Cochlear Intervention:   Procedure: Electrocochleography Sponsor:   Guy's and St Thomas' NHS Foundation Trust Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2tz60Ff

“Return to play” after facial injuries: is it time for a consensus view?

The telephone rings: "Mr X has had a fractured jaw repaired but we've been told that he's not to play for three months – we desperately need him – when do you think he can play again?" You see another player with an asymptomatic fracture of the orbital floor: "When can I play again?" These are both hypothetical, but very common.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GS78f3

Tubomanometry and EarPopper Devices for Eustachian Tube Function Testing

Condition:   Eustachian Tube Dysfunction Interventions:   Device: EarPopper;   Device: Tympanometry;   Device: Tubomanometry Sponsors:   University of Pittsburgh;   National Institute on Deafness and Other Communication Disorders (NIDCD) Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2tty250

Subject ´s Preference Regarding Hearing Performance and Functionality Using a New Sound Processor

Conditions:   Deafness; Sensoneural Single Sided;   Conductive Hearing Loss;   Mixed Hearing Loss Intervention:   Device: Investigational device - Sound Processor Sponsor:   Cochlear Bone Anchored Solutions Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GS73bf

Electrocochleography Function for Monitoring Residual Hearing

Condition:   Hearing Loss, Cochlear Intervention:   Procedure: Electrocochleography Sponsor:   Guy's and St Thomas' NHS Foundation Trust Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2tz60Ff

Simultaneous occurrence of benign and malignant tumours in the ipsilateral parotid gland—retrospective study

The simultaneous occurrence of benign and malignant tumours in the ipsilateral parotid gland is extremely rare. The cases of five patients with synchronous multiple parotid gland tumours consisting of diverse combinations of benign and malignant histological types are presented here. In addition, all published cases of this entity identified in the PubMed, Embase, and Web of Science databases up to January 2018 were reviewed. It is concluded that clinical vigilance should be raised when multifocal tumours are indicated by imaging examinations, in the presence of unmovable, painful, and rapid growth or symptoms of facial nerve palsy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BQeMmJ

Simultaneous occurrence of benign and malignant tumours in the ipsilateral parotid gland—retrospective study

The simultaneous occurrence of benign and malignant tumours in the ipsilateral parotid gland is extremely rare. The cases of five patients with synchronous multiple parotid gland tumours consisting of diverse combinations of benign and malignant histological types are presented here. In addition, all published cases of this entity identified in the PubMed, Embase, and Web of Science databases up to January 2018 were reviewed. It is concluded that clinical vigilance should be raised when multifocal tumours are indicated by imaging examinations, in the presence of unmovable, painful, and rapid growth or symptoms of facial nerve palsy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BQeMmJ

Lack of Protein Prenylation Promotes Nlrp3 Inflammasome Assembly in Human Monocytes

We demonstrate that blocking the mevalonate pathway and protein prenylation in human monocytes leads to enhanced activity of an NLRP3-dependent, but not Pyrin-dependent, inflammasome, suggesting a prominent role for NLRP3 in the pathogenesis of mevalonate kinase deficiency.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Eo6c0a

Lack of Protein Prenylation Promotes Nlrp3 Inflammasome Assembly in Human Monocytes

We demonstrate that blocking the mevalonate pathway and protein prenylation in human monocytes leads to enhanced activity of an NLRP3-dependent, but not Pyrin-dependent, inflammasome, suggesting a prominent role for NLRP3 in the pathogenesis of mevalonate kinase deficiency.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Eo6c0a