Authors: Lubrano E, Scriffignano S, Perrotta FM Abstract INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by the presence of psoriasis, arthritis and enthesitis, with the association of other musculoskeletal and extra-articular manifestations. Current treatment of PsA is mainly based on the use of conventional, biological and targeted synthetic DMARDs; however, patients may not respond or have a loss of response to these agents. Recently, a deeper understanding of the pathogenetic mechanisms has made possible the development of new drugs that actively interact with the activation of immune system, inhibiting the co-stimulation between antigen presenting cells and lymphocytes. Areas Covered: The aim of this paper is to review the role of the ac...
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