Allergic contact dermatitis: Adequacy of the default 10X assessment factor for human variability to protect infants and children

Publication date: Available online 18 September 2018Source: Regulatory Toxicology and PharmacologyAuthor(s): Susan Felter, Cindy Ryan, Petra KernAbstractWhen evaluating consumer products for safety, one must consider the heterogeneity of the population that might use those products, including the potential for different sensitivity based on factors such as age, gender, and genetics. For both systemic endpoints and allergic contact dermatitis (ACD), quantitative safety evaluations typically include a default 10-fold uncertainty/assessment factor to account for inter-individual variability. While this factor is intended to include age, the adequacy of the default 10-fold factor has been questioned for infants, for whom a precautionary assumption is often made that they are more sensitive. In...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xk1Bbs