Publication date: Available online 13 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Matt D. Johansen, Elinor Hortle, Joshua A. Kasparian, Alejandro Romero, Beatriz Novoa, Antonio Figueras, Warwick J. Britton, Kumudika de Silva, Auriol C. Purdie, Stefan H. OehlersAbstractChanges to lipid metabolism are well-characterised consequences of human tuberculosis infection but their functional relevance are not clearly elucidated in these or other host-mycobacterial systems. The zebrafish-Mycobacterium marinum infection model is used extensively to model many aspects of human-M. tuberculosis pathogenesis but has not been widely used to study the role of infection-induced lipid metabolism. We find mammalian mycobacterial infection-induced alterations in host Low Density Lipoprotein met...
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