Antimicrobial photodynamic therapy alone or in combination with antibiotic local administration against biofilms of Fusobacterium nucleatum and Porphyromonas gingivalis

Publication date: Available online 12 September 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Lívia J. Tavares, Erica D. de Avila, Marlise I. Klein, Beatriz H.D. Panariello, Denise M.P. Spolidório, Ana Cláudia PavarinaAbstractAntimicrobial photodynamic therapy (aPDT) kills several planktonic pathogens. However, the susceptibility of biofilm-derived anaerobic bacteria to aPDT is poorly characterized. Here, we evaluated the effect of Photodithazine (PDZ)-mediated aPDT on Fusobacterium nucleatum and Porphyromonas gingivalis biofilms. In addition, aPDT was tested with metronidazole (MTZ) to explore the potential antimicrobial effect of the treatment. The minimum inhibitory concentration (MIC) of MTZ was defined for each bacterial species. Single-species biofilm...

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