CONCLUSIONS: Hence, we suggest that targeting intra-tumor DCs to elicit expression of CD40 and ICOSL and present broad range of tumor antigens could yield effective anti-tumor responses. In this regard, CD40 molecule manipulation trigger stronger functions, while mRNA/chitosan nanoparticles system could provide a high potent tool for targeting strategies. PMID: 30265161 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
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