Fine Mapping Epitope on Glycoprotein-Gn from Crimean-Congo Hemorrhagic Fever virus

Publication date: Available online 11 September 2018Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Alai Shalitanati, Huan Yu, Dongliang Liu, Wan-Xiang Xu, Xihong Yue, Rong Guo, Yijie Li, Fei Deng, Jianhua Yang, Yujiang Zhang, Surong SunAbstractGlycoprotein (GP) is a major antigen of Crimean-Congo hemorrhagic fever virus (CCHFV), and binds to its receptor on the host cell and induces protective immunity in the host. The aim of this study is to identify all linear B cell epitopes (BCEs) on the N-terminal glycoprotein (Gn) of CCHFV using a modified overlapping peptide biosynthesis method. The eight fine BCEs (Gn-E1a, 543RTQLV547; E1b, 553EIH555; E1c, 554IHEDSY559; E1d, 557DSYG560; E2, 615CKQGFC620; E3a, 657GDILVD662; E3b, 662DCSGGQQH669, and E4, 678LGCPNVPL685)...

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