Pentraxin 3 is up-regulated in epithelial mammary cells during Staphylococcus aureus intra-mammary infection in goat

Publication date: Available online 11 September 2018Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): J. Filipe, G. Curone, V. Bronzo, G. Pisoni, P. Cremonesi, C. Pollera, L. Turin, D. Vigo, P. Roccabianca, M. Caniatti, P. Moroni, F. RivaAbstractPentraxin 3 is the prototypic long pentraxin and is produced by different cell populations (dendritic cells, monocytes/macrophages, endothelial cells, and fibroblasts) after pro-inflammatory stimulation. Different studies demonstrated the up-regulation of PTX3 during mastitis in ruminants, but its role is still unknown. We first investigated the conservation of PTX3 sequence among different species and its pattern of expression in a wide panel of organs from healthy goats. We studied the modulation of PTX3 during natura...

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