The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance.

Authors: Zhao B, Chang L, Fu H, Sun G, Yang W Abstract Autoimmune regulator (AIRE), whose gene mutation is considered to be a causative factor of autoimmune polyglandular syndrome type 1 (APS1), is an important transcriptional regulator. Studies on the role of AIRE in the central immune system have demonstrated that AIRE can eliminate autoreactive T cells by regulating the expression of a series of tissue specific antigens promiscuously in medullary thymic epithelial cells (mTECs) and induce regulatory T cell (Treg) production to maintain central immune tolerance. However, the related research of AIRE in peripheral tolerance is few. In order to understand the current research progress on AIRE in peripheral tolerance, this review mainly focuses on the expression and distribution of ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xSCPi9