Uncharted Waters: Challenges in the Era of Biologic Therapies for Nasal Polyposis

Publication date: Available online 11 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jayant M. Pinto, Fuad M. Baroody, Robert M. NaclerioSeveral new, promising, targeted therapies for nasal polyposis are being tested in large-scale clinical trials. These agents target pathways thought to be involved in the disease, including IgE, IL-5, IL-4/IL-13, and others. Designing these trials poses significant challenges: who and when to enroll is not completely clear, optimal dosing is not known, outcome measures are insufficiently robust, there are no validated biomarkers, trial regimens may not comport with how clinicians might use these drugs once approved, and cost-benefit ratios have not been assessed. Thus, there is a need to consider such questions...

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