Bee venom improves diabetic wound healing by protecting functional macrophages from apoptosis and enhancing Nrf2, Ang-1 and Tie-2 signaling

Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Wael N. Hozzein, Gamal Badr, Badr M. Badr, Ahmed Allam, Ahmad Al Ghamdi, Mohammed A. Al-Wadaan, Noori S. Al-WailiAbstractImpaired wound healing is a serious complication of diabetes that negatively affects the patient's socioeconomic life. Multiple mechanisms contribute to impaired diabetic wound healing including deficient recruitment of wound macrophages/neutrophils and impaired neovascularization. Bee venom (BV) has been used as an anti-inflammatory agent for the treatment of several diseases. Nevertheless, the impacts of BV on the diabetic wound healing have been poorly studied. In the present study, we investigated the molecular mechanisms underlying BV treatment on diabetic wound healing in a type I d...

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