Chronic rhinosinusitis with nasal polyps: insights into mechanisms of disease from emerging biological therapies.

Authors: Kariyawasam HH Abstract INTRODUCTION: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex disease of the upper airway, with long term morbidity. With detailed mechanistic studies currently lacking, understanding of the immunopathogenesis is still limited. However, outcomes from CRSwNP clinical studies using biologics that block key mediators or cells may provide some insight into how immune signalling pathways potentially integrate and modulate each other and contribute to disease. Current treatments are often ineffective and there is an urgent unmet clinical need for effective therapeutic strategies. Emerging biologics hold promise. Areas covered: This review covers the biology of CRSwNP in terms of the clinical outcomes reported from blocking immune cascades w...

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