Ox40 regulates the conversion and suppressive function of double-negative regulatory T cells.

In conclusion, we elucidated that Ox40 promotes the conversion and maintenance of DNT. Ox40 deficiency reduced the regulatory function of DNT both in vitro and in vivo by regulating proliferation, apoptosis, and suppression-related genes. PMID: 30268799 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)

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