Prostaglandin E2 facilitates Hepatitis B virus replication by impairing CTL function

Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Xiaoyan Li, Tingting Xie, Lifen Gao, Chunhong Ma, Xiaoyun Yang, Xiaohong LiangAbstractReversal of T cell dysfunction is a novel and promising approach for the treatment of chronic diseases. PGE2, one of most studied Prostaglandins, exhibits strong and versatile immunoregulation activity on different immune cells including T cells, and has become a promising therapeutic target. Here we found that compared to healthy donors, patients with chronic Hepatitis B virus (HBV) infection had significantly elevated serum PGE2 level. Importantly, serum PGE2 concentration correlated with viral load and liver damage in Chronic hepatitis B(CHB)patients. In AAV-HBV1.2 mouse model, administration of PGE2 analogue promoted HBV...

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