S-nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells

Publication date: Available online 23 October 2018Source: Pharmacological ResearchAuthor(s): Yusheng Lu, Shu Lian, Yuying Ye, Ting Yu, Haiyan Liang, Yunlong Cheng, Jingjing Xie, Yewei Zhu, Xiaodong Xie, Suhong Yu, Yu Gao, Lee JiaAbstractA perfect microenvironment facilitates the activated circulating tumor cells (CTCs) to spark the adhesion-invasion-extravasation metastatic cascade in their premetastatic niche. Platelet-CTC interaction contributes to the progression of tumor malignancy by protecting CTCs from shear stress and immunological assault, aiding CTCs entrapment in the capillary bed, enabling CTCs to successfully exit the bloodstream and enter the tissue, inducing epithelial-mesenchymal-like transition (EMT), and assisting in the establishment of metastatic foci. To prevent the ca...

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