Antioxidative, inflammatory and immune responses in hydrogen peroxide-induced liver injury of tilapia (GIFT, Oreochromis niloticus)

Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Rui Jia, Jinliang Du, Liping Cao, Yao Li, Opigo Johnson, Zhengyan Gu, Galina Jeney, Pao Xu, Guojun YinAbstractOxidative stress has been implicated in the pathogenesis of many liver diseases in fish, but the molecular mechanism is still obscure. Here, we used hydrogen peroxide (H2O2) as a reactive oxygen species (ROS) to induce liver injury and assess underlying molecular mechanism linking oxidative stress and liver injury in fish. Tilapia were injected with various concentrations of H2O2 (0, 40, 120, 200, 300 and 400 mM) for 72 h. The blood and liver were collected to assay biochemical parameters and genes expression after 24, 48 and 72 h of injection. The results showed that treatments with higher...

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