Detection and monitoring of in vitro formation of salicylic acid from aspirin using fluorescence spectroscopic technique and DFT calculations

Publication date: Available online 8 November 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Ranjana Singh, Manish Kumar Tiwari, Debraj Gangopadhayay, Phool Chand Mishra, Hirdyesh Mishra, Anchal Srivastava, Ranjan K. SinghAbstractAcetylsalicylic acid commonly termed as aspirin (AS) is a well known antipyretic and anti-inflammatory drug which can also be used to reduce death risks due to heart attack. In addition to this, it also exhibits some adverse effect such as gastrointestinal, tinnitus, Reye's syndrome. The side effects of AS such as gastrointestinal ulcer, tinnitus and Reye's syndrome are caused due to conversion of AS into its active metabolite salicylic acid (SAL). Conversion of AS into SAL has been investigated generally at basic pH. Since the pH of G...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PRFIL2