During acute graft versus host disease CD28 deletion in donor CD8+, but not CD4+, T cells maintain antileukemia responses in mice

CD28 costimulation of alloreactive CD4+ T  cells provides crucial help to CD8+ T  cells. Alloreactive CD8+ T  cells, however, do not require CD28 costimulation to differentiate into cytotoxic T cells mediating the curative graft versus leukemia (GvL) effect in vivo. . AbstractDonor lymphocyte infusions together with allogeneic hematopoietic stem cell transplantation are routinely used as second ‐line treatment for hematological malignancies. Mature T cells in the graft crucially mediate a graft versus leukemia (GvL) response, but also attack healthy tissues in the recipient leading to potentially life‐threatening acute graft versus host disease. Using inducible CD28 knockout C57BL/6 m ice as T‐cell donors, we have now assessed whether CD28 costimulation of donor CD4+ and/ or C...

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