HDAC2 attenuates airway inflammation by suppressing IL17A production in HDM-challenged mice.

Authors: Lai T, Wu M, Zhang C, Che L, Xu F, Wang Y, Wu Y, Xuan N, Cao C, Du X, Wu B, Li W, Ying S, Shen H, Chen Z Abstract Histone deacetylase (HDAC) 2 is expressed in airway epithelium and plays a pivotal role in inflammatory cells. However, the role of HDAC2 in allergic airway inflammation remains poorly unknown. In the present study, we determined the role of HDAC2 in airway inflammation using in vivo models of HDM-induced allergic inflammation and in vitro cultures of human bronchial epithelial (HBE) cells exposed to HDM, IL17A, or both. We observed that HDM-challenged Hdac2+/- mice exhibited substantially enhanced infiltration of inflammatory cells. Higher levels of Th2 cytokines and IL17A expression were found in lung tissues of HDM-challenged Hdac2+/- mice. Interestingly, IL...

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