Publication date: Available online 20 November 2018Source: Redox BiologyAuthor(s): Ye-Ri Kim, Jeong-In Baek, Sung Hwan Kim, Min-A. Kim, Byeonghyeon Lee, Nari Ryu, Kyung-Hee Kim, Deok-Gyun Choi, Hye-Min Kim, Michael P. Murphy, Greg Macpherson, Yeon-Sik Choo, Jinwoong Bok, Kyu-Yup Lee, Jeen-Woo Park, Un-Kyung KimAbstractMitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) is a major NADPH-producing enzyme which is essential for maintaining the mitochondrial redox balance in cells. We sought to determine whether IDH2 deficiency induces mitochondrial dysfunction and modulates auditory function, and investigated the protective potential of an antioxidant agent against reactive oxygen species (ROS)-induced cochlear damage in Idh2 knockout (Idh2−/−) mice. Idh2 deficiency leads to d...
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